cutaneous melanoma: A primary melanoma arising from atypical melanocytes in the skin. Precursor lesions include acquired and congenital melanocytic nevi, and dysplastic nevi. Several histologic variants have been recognized, including superficial spreading melanoma, acral lentiginous melanoma, nodular melanoma, and lentigo maligna melanoma.
Melanocytic naevi of ear and external auricular canal
DOID EFO Endpoint Browser PheWeb
CD2_BENIGN_MELANOCYTIC_EAR
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
216 |
4. Check minimum number of eventsNone |
216 |
5. Include endpointsNone |
216 |
6. Filter based on genotype QC (FinnGen only) |
212 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D22
- Name in latin
- Naevus melanocyticus (cutis) auriculae
Similar endpoints
↥List of similar endpoints to
Melanocytic naevi of ear and external auricular canal
based on the number of shared cases.
Similar with more cases:
- Melanocytic naevi
- Benign neoplasms
- Neoplasms
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1330 | 810 | 508 |
| Only index persons | 1251 | 778 | 473 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 49.38 | 45.07 | 56.22 |
| Only index persons | 48.91 | 44.97 | 55.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 212 | 139 | 73 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | 52.03 | 45.66 | 64.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 216
- Matched controls
- 2160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D22.2
ICD-10 Finland
Melanocytic naevi of ear and external auricular canal
4503599627370496.0
288.4
208
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
12.4
62.0
74
87
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.3
32.8
57
101
DAB00
NOMESCO Finland
Excision of lesion of auricle
55.3
28.4
33
7
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
8.1
27.4
41
61
D23.2
ICD-10 Finland
Benign neoplasm: Skin of ear and external auricular canal
31.3
15.5
20
7
R23.8
ICD-10 Finland
Other and unspecified skin changes
3.4
14.2
67
254
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
5.4
14.0
30
63
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
5.0
13.6
32
73
S82
ICPC
Naevus/mole
3.3
11.8
53
193
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
12.1
10.8
19
17
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
4.4
9.5
25
62
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
10.7
9.2
17
17
DAB10
NOMESCO Finland
Partial excision of auricle
38.4
9.1
11
*
D22.3
ICD-10 Finland
Melanocytic naevi of other and unspecified parts of face
8.8
8.8
18
22
2162A
ICD-9 Finland
Benign neoplasm of skin, Ear and external auditory canal[KORVAN IHON BEN KASVAIN,NAEVUS PIGMENTOSUS]
+∞
8.4
8
*
TQW99
NOMESCO Finland
Other minor procedure on skin
4.4
8.0
21
52
XQ848
NOMESCO Finland
Dermatological photography
9.0
8.0
16
19
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
4.1
7.4
21
55
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
3.5
7.1
25
77
D22.4
ICD-10 Finland
Melanocytic naevi of scalp and neck
14.4
7.0
11
8
XQ845
NOMESCO Finland
Dermatoscopy
9.8
6.9
13
14
D22
ICD-10 Finland
Melanocytic naevi
4.1
6.7
19
50
L57.0
ICD-10 Finland
Actinic keratosis
2.9
6.5
33
127
TDA10
NOMESCO Finland
Needle biopsy of auricle or external auditory canal
27.6
6.3
8
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
52
287
2.07
4.61
1.8
2.6
0.50
0.96
e6/l
1.63
28
163
25
104
2.59
4.24
3.5
2.9
173.36
247.87
ng/l
0.53
25
92
109
803
1.72
3.76
4.6
6.1
1.21
1.21
mmol/l
0.49
97
698
94
665
1.73
3.75
2.2
1.9
101.67
93.50
pmol/l
0.89
51
347
51
307
1.87
3.47
3.7
3.3
78.83
184.89
ng/l
0.86
36
213
93
682
1.64
3.10
4.3
4.2
35.57
35.81
g/l
0.15
82
645
36
207
1.89
2.80
2.7
2.5
22.81
22.67
%
0.02
31
180
43
268
1.75
2.58
1.9
2.8
3.28
3.02
e6/l
0.05
18
145
18
84
2.25
2.42
2.0
1.8
—
—
—
0
0
32
186
1.85
2.41
1.5
2.5
7.40
6.90
umol/l
0.07
25
159
112
897
1.52
2.37
5.8
5.9
11.27
10.88
umol/l
0.15
105
848
82
619
1.52
2.27
2.8
3.0
—
—
—
0
0
95
742
1.50
2.23
4.2
5.2
1.21
1.21
mmol/l
0.36
88
685
68
495
1.55
2.21
2.5
2.8
0.19
0.42
e6/l
1.27
53
375
155
1342
1.55
2.19
8.0
7.0
77.35
76.68
u/l
0.07
147
1260
6
14
4.38
2.16
2.3
1.8
—
—
—
0
0
8
26
3.15
2.03
1.1
1.3
—
108.43
—
0
7
194
1785
1.85
2.03
13.4
13.0
23.13
22.67
mg/l
0.06
155
1383
31
191
1.73
1.94
5.4
7.7
—
—
—
0
0
5
12
4.24
1.83
2.2
4.3
—
—
—
0
0
61
451
1.49
1.81
3.4
3.7
4.05
12.82
mg/mmol
2.05
34
292
37
245
1.62
1.78
1.5
1.9
—
—
—
0
0
90
726
1.41
1.67
2.5
2.3
74.77
76.18
nmol/l
0.17
82
657
6
19
3.22
1.67
1.3
1.1
—
1.17
—
0
6
8
32
2.56
1.61
1.1
1.3
—
—
—
0
0
14
76
1.90
1.33
1.3
1.9
—
—
—
0
0
5
19
2.67
1.22
1.4
1.1
—
—
—
0
0
198
1883
1.62
1.14
10.9
9.6
23.13
24.37
u/l
0.70
190
1816
70
573
1.33
1.12
2.5
2.8
24.39
30.02
u/l
2.74
62
549
7
31
2.30
1.11
2.7
2.5
3.07
6.50
umol/l
—
7
22
141
1272
1.31
1.10
3.3
3.6
—
—
—
0
0
12
67
1.84
1.07
1.6
2.3
—
—
—
0
0
183
1722
1.41
1.02
4.2
4.1
4.75
4.68
mmol/l
0.43
170
1611
24
165
1.51
1.02
3.3
4.5
2.99
34.21
ug/l
0.66
17
138
52
413
1.34
1.01
1.6
1.5
20.27
20.95
nmol/l
0.11
45
353
0
29
0.00
0.98
0.0
1.6
—
—
—
0
0
11
62
1.82
0.96
1.7
2.1
—
—
—
0
0
0
32
0.00
0.96
0.0
1.5
—
—
—
0
0
117
1042
1.27
0.95
9.7
8.8
4.35
4.12
e9/l
0.51
99
904
51
408
1.33
0.95
1.8
2.2
—
—
—
0
0
10
169
0.57
0.93
2.8
3.3
—
—
—
0
0
53
428
1.32
0.92
2.6
2.0
2.55
3.03
mg/l
0.64
43
375
97
848
1.26
0.91
2.4
2.5
—
—
—
0
0
25
178
1.46
0.91
5.1
6.6
1.84
0.93
mmol/l
0.46
17
141
15
95
1.62
0.90
2.9
2.2
21089.88
5827.42
u/l
—
8
35
22
153
1.49
0.90
1.5
1.6
—
—
—
0
0
83
716
1.26
0.87
13.1
11.3
1.06
1.19
inr
1.56
14
218
23
163
1.46
0.86
1.6
1.8
—
—
—
0
0
168
1575
1.30
0.84
5.7
5.1
38.45
39.08
mmol/mol
0.45
157
1476
43
343
1.32
0.82
4.9
4.8
22.24
21.57
%
0.09
17
187
53
436
1.29
0.81
5.7
5.3
1.89
3.10
ug/l
0.85
45
376
13
82
1.62
0.80
1.4
1.4
—
—
—
0
0
13
82
1.62
0.80
1.4
1.4
—
—
—
0
0
99
878
1.24
0.80
4.9
4.9
0.00
0.00
estimate
-0.00
12
189
0
24
0.00
0.79
0.0
1.6
—
—
—
0
0
23
166
1.43
0.79
1.5
1.8
—
—
—
0
0
0
25
0.00
0.79
0.0
1.4
—
—
—
0
0
184
1751
1.34
0.79
4.9
4.5
2.77
2.77
mmol/l
0.01
171
1630
13
83
1.60
0.77
1.4
1.4
—
—
—
0
0
13
83
1.60
0.77
1.4
1.4
—
—
—
0
0
62
524
1.26
0.76
2.1
2.4
57.26
65.97
u/l
0.40
54
496
149
1385
1.24
0.75
3.9
3.9
14.49
14.62
pmol/l
0.26
135
1261
5
24
2.11
0.75
1.0
1.1
—
—
—
0
0
5
25
2.02
0.73
6.8
2.8
5.60
3.15
nmol/l
—
5
25
99
888
1.21
0.69
3.3
3.5
0.00
0.00
estimate
-0.00
14
197
38
306
1.29
0.68
2.8
2.5
2.44
2.44
mmol/l
0.01
33
273
14
94
1.52
0.68
1.4
1.5
—
—
—
0
0
46
381
1.26
0.67
3.9
1.7
1.59
1.14
mg/l
0.24
35
294
99
891
1.21
0.66
3.3
3.5
0.00
0.02
estimate
0.50
12
181
96
863
1.20
0.65
3.2
2.8
78.45
96.46
ug/l
0.59
91
810
37
301
1.28
0.62
1.5
1.6
1096.47
1139.47
nmol/l
0.12
27
234
193
1864
1.33
0.60
16.1
14.7
75.68
74.86
umol/l
0.10
193
1864
66
577
1.21
0.59
3.4
2.9
2.35
2.35
mmol/l
0.01
52
514
0
23
0.00
0.58
0.0
1.7
—
14.72
—
0
6
179
1715
1.26
0.58
4.2
4.1
1.50
1.51
mmol/l
0.14
165
1595
130
1209
1.19
0.58
3.2
2.9
38.70
41.01
u/l
0.19
121
1148
6
35
1.73
0.58
1.2
1.2
—
—
—
0
0
24
186
1.33
0.57
1.6
1.8
—
—
—
0
0
108
994
1.17
0.53
4.5
4.2
6.52
6.43
mmol/l
0.20
97
908
9
63
1.45
0.53
1.3
2.0
—
—
—
0
0
15
109
1.40
0.52
1.3
1.2
188.13
118.56
u/ml
0.35
15
96
203
1983
1.39
0.49
22.0
19.1
257.09
254.58
e9/l
0.23
198
1940
203
1983
1.39
0.49
22.1
19.1
40.47
39.98
%
0.51
185
1881
50
433
1.20
0.49
1.1
1.3
0.73
1.65
u/ml
—
6
124
19
147
1.32
0.47
1.2
1.7
—
—
—
0
0
203
1985
1.38
0.47
22.1
19.1
4.57
4.49
e12/l
1.56
198
1937
5
81
0.61
0.46
2.4
2.6
1.18
1.25
%
—
5
81
50
436
1.19
0.46
4.6
3.2
844.22
1280.76
ng/l
0.89
43
361
42
485
0.83
0.45
3.6
3.6
0.00
0.00
estimate
-0.00
14
183
7
50
1.41
0.45
1.6
1.4
—
8.82
—
0
12
5
33
1.53
0.41
1.8
1.3
—
—
—
0
0
5
33
1.53
0.41
1.8
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.3
—
—
—
0
0
7
103
0.67
0.40
1.1
1.3
18.41
24.06
iu/l
—
7
89
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
174
1681
1.18
0.40
4.7
4.2
5.95
5.80
mmol/l
0.97
159
1551
171
1650
1.17
0.39
3.9
3.7
1.30
1.22
mmol/l
0.94
156
1522
23
188
1.25
0.39
4.4
4.6
30.15
33.31
%
0.75
13
123
0
19
0.00
0.39
0.0
4.2
—
—
—
0
0
10
72
1.41
0.37
1.8
1.4
—
—
—
0
0
9
70
1.30
0.37
1.4
1.6
—
—
—
0
0
6
41
1.48
0.36
1.2
1.2
—
—
—
0
0
172
1667
1.16
0.34
4.9
4.6
2.13
2.55
mu/l
0.23
156
1533
7
99
0.70
0.31
1.0
1.0
—
—
—
0
0
7
53
1.33
0.31
1.7
1.5
—
—
—
0
0
23
195
1.20
0.29
5.7
6.2
104.65
104.52
mmol/l
0.05
23
195
14
172
0.80
0.28
1.7
1.6
—
—
—
0
0
8
63
1.28
0.28
1.8
1.7
—
—
—
0
0
8
63
1.28
0.28
4.6
1.3
—
—
—
0
0
8
64
1.26
0.28
1.4
1.8
—
192.00
—
0
5
10
78
1.30
0.24
1.2
1.5
257.60
285.45
mu/l
—
10
71
136
1313
1.10
0.24
3.7
3.8
11.85
11.01
mm/h
0.24
123
1222
7
91
0.76
0.23
1.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
30.86
—
0
7
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
6
48
1.26
0.20
3.8
2.0
147.28
250.77
ug/l
—
6
43
0
14
0.00
0.20
0.0
1.9
—
4.43
—
0
7
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
3.6
—
—
—
0
0
6
50
1.21
0.20
1.5
1.7
—
0.06
—
0
13
58
618
0.92
0.19
2.7
4.0
20.61
31.20
ng/l
0.84
33
393
7
61
1.15
0.17
1.4
1.1
—
—
—
0
0
7
61
1.15
0.17
1.4
1.1
—
—
—
0
0
8
69
1.17
0.16
1.0
1.4
—
—
—
0
0
8
71
1.13
0.16
1.5
1.6
—
—
—
0
0
27
296
0.90
0.16
1.4
2.1
—
—
—
0
0
73
697
1.07
0.15
3.1
3.5
—
—
—
0
0
17
150
1.14
0.15
1.2
1.2
105.33
126.63
iu/ml
—
6
65
170
1672
1.08
0.14
13.3
12.0
84.75
85.07
ml/min/173m2
0.07
137
1352
15
133
1.14
0.12
2.7
3.0
79.86
70.05
ml/min/173m2
—
7
56
27
252
1.08
0.10
3.0
3.1
0.66
0.77
ug/l
0.29
18
174
49
469
1.06
0.09
1.5
1.6
1.26
1.35
mmol/l
0.51
43
408
35
332
1.06
0.08
1.3
1.7
400.34
452.50
pmol/l
0.70
29
283
12
108
1.12
0.07
1.2
1.5
—
—
—
0
0
16
147
1.10
0.07
2.2
3.9
3.23
1.88
mmol/l
0.85
11
111
41
396
1.04
0.05
1.5
1.6
—
—
—
0
0
10
110
0.90
0.05
1.3
1.3
—
—
—
0
0
39
380
1.03
0.03
1.4
1.4
—
—
—
0
0
31
319
0.97
0.02
1.5
2.2
—
—
—
0
0
33
336
0.98
0.00
1.3
1.2
23.17
34.78
iu/ml
—
10
108
10
99
1.01
0.00
3.2
1.9
13.40
13.07
nmol/l
—
10
90
32
321
1.00
0.00
1.2
1.2
6.98
8.52
u/ml
0.09
14
126
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
1830.38
—
0
8
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.87
-0.00
1.8
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
9.0
—
—
—
0
0
5
50
1.00
-0.00
1.8
2.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
12
120
1.00
-0.00
4.8
3.4
4.47
4.68
pmol/l
0.26
12
108
5
50
1.00
-0.00
1.4
1.4
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.0
—
140.50
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_MELANOCYTIC_EAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MELANOCYTIC_EAR | 1.145 [0.83, 1.59] | 0.414 |
| Birth year | 0.995 [0.99, 1.0] | 0.269 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 636 females with CD2_BENIGN_MELANOCYTIC_EAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MELANOCYTIC_EAR | 1.019 [0.75, 1.38] | 0.902 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 390 males with CD2_BENIGN_MELANOCYTIC_EAR died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_MELANOCYTIC_EAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.13% | 0.203% |
| 5 | 0.676% | 1.113% |
| 10 | 1.628% | 2.915% |
| 15 | 3.122% | 5.533% |
| 20 | 5.382% | 9.116% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_MELANOCYTIC_EAR – Melanocytic naevi of ear and external auricular canal
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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