cutaneous melanoma: A primary melanoma arising from atypical melanocytes in the skin. Precursor lesions include acquired and congenital melanocytic nevi, and dysplastic nevi. Several histologic variants have been recognized, including superficial spreading melanoma, acral lentiginous melanoma, nodular melanoma, and lentigo maligna melanoma.
Melanocytic naevi of ear and external auricular canal
DOID EFO Endpoint Browser PheWeb
CD2_BENIGN_MELANOCYTIC_EAR
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
196 |
4. Check minimum number of eventsNone |
196 |
5. Include endpointsNone |
196 |
6. Filter based on genotype QC (FinnGen only) |
196 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D22
- Name in latin
- Naevus melanocyticus (cutis) auriculae
Similar endpoints
↥List of similar endpoints to
Melanocytic naevi of ear and external auricular canal
based on the number of shared cases.
Similar with more cases:
- Melanocytic naevi of ear and external auricular canal
- Melanocytic naevi
- Melanocytic naevi
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1330 | 810 | 508 |
| Only index persons | 1251 | 778 | 473 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 49.38 | 45.07 | 56.22 |
| Only index persons | 48.91 | 44.97 | 55.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 196 | 128 | 68 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | 52.02 | 46.05 | 63.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 184
- Matched controls
- 1841
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D22.2
ICD-10 Finland
Melanocytic naevi of ear and external auricular canal
+∞
244.7
176
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
10.7
29.7
62
83
DAB00
NOMESCO Finland
Excision of lesion of auricle
42.9
21.4
26
7
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.1
17.7
46
82
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
7.4
13.2
32
51
D23.2
ICD-10 Finland
Benign neoplasm: Skin of ear and external auricular canal
32.4
11.8
15
5
S82
ICPC
Naevus/mole
3.8
9.2
41
129
2162A
ICD-9 Finland
Benign neoplasm of skin, Ear and external auditory canal[KORVAN IHON BEN KASVAIN,NAEVUS PIGMENTOSUS]
+∞
8.4
8
*
R23.8
ICD-10 Finland
Other and unspecified skin changes
3.5
8.4
41
139
D22.3
ICD-10 Finland
Melanocytic naevi of other and unspecified parts of face
9.1
8.0
16
19
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
5.2
7.6
23
49
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
10.0
7.4
14
15
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
8.1
7.1
15
20
DAB10
NOMESCO Finland
Partial excision of auricle
41.6
6.8
8
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
4.2
6.1
22
57
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
24
99
2.62
4.16
3.5
2.9
178.8
249.3
ng/l
0.47
24
88
100
737
1.73
3.49
4.6
6.3
1.2
1.2
mmol/l
0.36
88
638
34
185
2.01
3.12
2.8
2.6
22.3
21.7
%
0.11
29
160
43
261
1.83
2.86
1.8
2.6
0.5
1.0
e6/l
1.23
25
150
83
606
1.64
2.85
2.3
1.9
101.4
93.7
pmol/l
0.70
43
316
45
284
1.76
2.63
3.8
3.3
90.2
195.2
ng/l
0.75
31
201
84
627
1.59
2.58
4.4
4.2
35.7
35.6
g/l
0.08
74
591
29
173
1.79
2.04
1.5
2.4
7.9
7.3
umol/l
0.08
22
149
83
648
1.49
1.95
2.6
2.3
73.4
77.0
nmol/l
0.55
75
584
87
686
1.48
1.95
4.2
5.2
1.2
1.2
mmol/l
0.29
80
629
141
1229
1.52
1.89
8.0
7.0
78.2
77.5
u/l
0.07
134
1153
34
219
1.67
1.84
1.5
2.0
—
—
—
0
0
7
23
3.12
1.81
1.1
1.3
—
98.4
—
0
5
6
18
3.40
1.76
1.3
1.1
—
1.2
—
0
5
7
24
2.99
1.74
1.1
1.4
—
—
—
0
0
29
183
1.69
1.69
5.6
7.8
—
—
—
0
0
175
1617
1.77
1.69
13.4
13.2
22.7
22.7
mg/l
0.01
140
1254
100
830
1.42
1.63
6.2
5.9
11.3
11.0
umol/l
0.13
94
783
110
938
1.39
1.48
9.2
8.9
4.4
4.1
e9/l
0.53
94
812
13
68
1.98
1.37
1.3
1.9
—
—
—
0
0
5
17
2.99
1.36
1.4
1.1
—
—
—
0
0
35
245
1.52
1.36
1.9
2.8
3.5
2.9
e6/l
0.10
16
135
66
526
1.38
1.30
2.5
2.8
23.9
29.5
u/l
2.78
58
501
8
153
0.50
1.20
3.0
3.4
—
—
—
0
0
25
167
1.57
1.19
5.1
6.7
1.8
0.9
mmol/l
0.43
16
130
57
450
1.38
1.18
2.5
2.9
0.2
0.4
e6/l
1.05
45
342
12
66
1.87
1.11
1.9
1.8
—
—
—
0
0
11
60
1.88
1.05
1.4
2.4
—
—
—
0
0
23
156
1.54
1.04
3.4
4.7
3.1
36.2
ug/l
0.66
16
130
13
77
1.74
0.98
3.2
2.0
23959.7
7094.7
u/l
—
7
26
0
31
0.00
0.97
0.0
1.5
—
—
—
0
0
137
1253
1.31
0.95
3.6
3.9
14.5
14.6
pmol/l
0.35
125
1141
48
382
1.34
0.94
2.7
2.0
2.5
3.0
mg/l
0.63
40
331
68
571
1.29
0.91
2.8
3.0
—
—
—
0
0
47
375
1.33
0.90
1.6
1.5
21.0
21.2
nmol/l
0.02
42
318
158
1478
1.36
0.90
18.3
13.8
40.3
39.9
%
0.27
115
1127
10
56
1.83
0.89
1.5
2.2
—
—
—
0
0
179
1712
1.53
0.88
10.8
9.6
23.2
24.4
u/l
0.60
171
1649
125
1136
1.28
0.87
3.2
3.5
—
—
—
0
0
40
314
1.34
0.86
4.6
4.8
22.7
21.9
%
0.10
14
170
0
25
0.00
0.79
0.0
1.4
—
—
—
0
0
49
401
1.30
0.79
5.6
5.3
1.8
3.1
ug/l
0.91
42
345
0
27
0.00
0.78
0.0
1.7
—
—
—
0
0
21
150
1.45
0.77
1.6
1.8
—
—
—
0
0
0
28
0.00
0.76
0.0
1.5
—
—
—
0
0
87
767
1.24
0.76
3.4
4.2
—
—
—
0
0
5
24
2.11
0.75
6.8
2.9
5.6
3.2
nmol/l
—
5
24
21
151
1.44
0.75
1.6
1.8
—
—
—
0
0
5
30
1.68
0.62
1.2
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.6
—
15.9
—
0
5
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
45
380
1.24
0.57
1.2
1.2
0.7
1.6
u/ml
—
6
107
14
100
1.43
0.53
1.3
1.3
197.4
126.9
u/ml
0.32
14
88
9
63
1.45
0.53
1.0
1.4
—
—
—
0
0
175
1693
1.31
0.52
16.2
15.0
76.4
75.3
umol/l
0.13
175
1693
44
375
1.22
0.51
1.8
2.2
—
—
—
0
0
9
65
1.40
0.51
1.8
1.4
—
—
—
0
0
48
416
1.20
0.48
4.6
3.2
868.6
1278.3
ng/l
0.77
41
342
17
129
1.35
0.47
1.4
1.6
—
—
—
0
0
163
1569
1.23
0.47
4.2
4.2
4.7
4.7
mmol/l
0.24
151
1460
60
535
1.18
0.44
3.5
3.0
2.3
2.3
mmol/l
0.15
47
474
87
800
1.16
0.43
4.5
4.9
0.0
0.0
estimate
—
10
168
8
56
1.45
0.43
1.4
2.1
—
—
—
0
0
11
79
1.42
0.41
1.4
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
2.0
—
—
—
0
0
0
16
0.00
0.41
0.0
4.4
—
—
—
0
0
0
16
0.00
0.41
0.0
2.0
—
—
—
0
0
0
16
0.00
0.41
0.0
2.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
10
71
1.43
0.40
1.3
1.4
—
—
—
0
0
10
71
1.43
0.40
1.3
1.4
—
—
—
0
0
39
447
0.84
0.40
3.6
3.6
0.0
0.0
estimate
0.00
12
163
33
282
1.20
0.38
1.6
1.6
1135.5
1146.5
nmol/l
0.03
24
222
33
282
1.20
0.38
2.8
2.5
2.4
2.4
mmol/l
0.33
28
251
9
68
1.34
0.38
1.2
1.4
257.4
288.6
mu/l
—
9
62
10
72
1.41
0.37
1.3
1.4
—
—
—
0
0
10
72
1.41
0.37
1.3
1.4
—
—
—
0
0
16
126
1.29
0.36
1.2
1.6
—
—
—
0
0
5
76
0.65
0.36
2.4
2.6
1.2
1.1
%
—
5
76
22
181
1.24
0.36
5.9
6.3
104.3
104.4
mmol/l
0.05
22
174
87
808
1.14
0.36
3.1
3.5
0.0
0.0
estimate
0.00
12
168
6
41
1.48
0.36
1.5
1.5
—
0.1
—
0
11
116
1098
1.14
0.36
3.3
2.9
39.5
42.5
u/l
0.24
107
1043
21
253
0.81
0.35
1.3
2.1
—
—
—
0
0
97
909
1.13
0.35
4.4
4.3
6.6
6.5
mmol/l
0.28
87
828
150
1446
1.16
0.35
5.7
5.3
38.5
39.3
mmol/mol
0.61
140
1354
6
90
0.66
0.33
1.2
1.3
20.2
23.3
iu/l
—
6
77
87
812
1.13
0.33
3.1
3.5
0.0
0.0
estimate
0.00
11
161
156
1510
1.16
0.33
4.6
4.6
2.2
2.6
mu/l
0.21
142
1382
7
53
1.33
0.31
1.4
1.2
—
—
—
0
0
7
53
1.33
0.31
1.4
1.2
—
—
—
0
0
164
1598
1.16
0.28
4.9
4.6
2.7
2.8
mmol/l
0.20
152
1479
19
159
1.22
0.28
1.4
1.8
—
—
—
0
0
52
566
0.89
0.27
2.8
4.0
20.4
32.1
ng/l
0.87
31
359
52
477
1.12
0.26
2.2
2.4
59.2
57.4
u/l
0.10
46
449
12
96
1.27
0.25
1.2
1.5
—
—
—
0
0
160
1562
1.13
0.24
4.3
4.2
1.5
1.5
mmol/l
0.02
147
1444
5
40
1.26
0.22
1.4
1.6
—
—
—
0
0
157
1533
1.12
0.22
4.7
4.2
5.9
5.8
mmol/l
0.60
143
1413
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
13
155
0.83
0.21
1.8
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
5.0
—
0
6
0
13
0.00
0.21
0.0
3.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
9
111
0.80
0.20
1.9
3.2
4.6
4.7
pmol/l
—
9
100
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
6
50
1.21
0.20
1.8
1.6
—
—
—
0
0
20
176
1.15
0.18
4.5
4.6
28.8
33.2
%
1.08
11
111
67
636
1.08
0.17
3.1
3.5
—
—
—
0
0
14
120
1.18
0.17
2.7
2.8
76.8
69.5
ml/min/173m2
—
6
52
40
430
0.91
0.16
1.5
1.6
1.3
1.4
mmol/l
0.71
35
372
6
79
0.75
0.16
1.0
1.5
—
—
—
0
0
38
353
1.09
0.15
4.4
1.7
1.8
1.1
mg/l
0.33
30
275
7
88
0.79
0.15
1.0
1.0
—
—
—
0
0
25
274
0.90
0.15
1.5
2.2
—
—
—
0
0
15
132
1.15
0.13
6.4
5.9
1.5
1.3
mmol/l
0.41
15
126
25
229
1.11
0.13
3.0
3.1
0.7
0.8
ug/l
0.23
16
156
153
1505
1.08
0.12
3.9
3.7
1.3
1.2
mmol/l
0.59
139
1381
5
44
1.14
0.10
1.8
2.4
—
—
—
0
0
5
44
1.14
0.10
1.8
1.3
—
10.1
—
0
10
5
44
1.14
0.10
1.4
1.3
—
—
—
0
0
32
302
1.07
0.09
1.4
1.7
384.6
453.5
pmol/l
0.99
26
260
6
54
1.11
0.09
1.3
1.5
—
—
—
0
0
7
64
1.10
0.08
1.6
1.6
—
—
—
0
0
12
131
0.91
0.06
1.3
1.2
120.4
142.9
iu/ml
—
5
59
121
1195
1.03
0.05
3.9
3.7
11.7
11.1
mm/h
0.15
110
1108
30
288
1.05
0.05
1.2
1.2
0.9
9.3
u/ml
2.18
12
110
153
1518
1.04
0.04
13.1
12.1
84.1
84.4
ml/min/173m2
0.07
123
1227
31
301
1.04
0.02
1.3
1.2
16.9
38.3
iu/ml
—
9
94
33
339
0.97
0.02
1.5
1.6
—
—
—
0
0
13
136
0.95
0.00
2.2
4.1
3.4
1.9
mmol/l
—
7
100
10
96
1.04
0.00
1.3
1.3
—
—
—
0
0
34
337
1.01
0.00
1.5
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
9
91
0.99
0.00
3.4
2.0
14.8
12.9
nmol/l
—
9
83
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
1789.0
—
0
7
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
9.2
—
—
—
0
0
5
57
0.87
0.00
3.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_MELANOCYTIC_EAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MELANOCYTIC_EAR | 1.145 [0.83, 1.59] | 0.414 |
| Birth year | 0.995 [0.99, 1.0] | 0.269 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 636 females with CD2_BENIGN_MELANOCYTIC_EAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MELANOCYTIC_EAR | 1.019 [0.75, 1.38] | 0.902 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 390 males with CD2_BENIGN_MELANOCYTIC_EAR died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_MELANOCYTIC_EAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.13% | 0.203% |
| 5 | 0.676% | 1.113% |
| 10 | 1.628% | 2.915% |
| 15 | 3.122% | 5.533% |
| 20 | 5.382% | 9.116% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_MELANOCYTIC_EAR – Melanocytic naevi of ear and external auricular canal
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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