No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
198 |
4. Check minimum number of eventsNone |
198 |
5. Include endpointsNone |
198 |
6. Filter based on genotype QC (FinnGen only) |
192 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of other and unspecified cranial nerves
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1570 | 846 | 707 |
| Only index persons | 1256 | 694 | 562 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 52.04 | 52.68 | 50.94 |
| Only index persons | 49.33 | 50.00 | 48.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 192 | 97 | 95 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 47.24 | 43.01 | 51.57 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 198
- Matched controls
- 1980
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G52.8
ICD-10 Finland
Disorders of other specified cranial nerves
+∞
83.4
74
*
G52.9
ICD-10 Finland
Cranial nerve disorder, unspecified
+∞
72.4
65
*
35608
ICD-8 Finland
Other diseases of cranial nerves, Alterius nervi
+∞
34.4
32
*
G51.0
ICD-10 Finland
Bell palsy
+∞
25.6
24
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.9
17.4
35
70
N03AX16
ATC
[U] pregabalin
3.9
17.3
67
228
35609
ICD-8 Finland
Other diseases of cranial nerves, Unspecified
+∞
16.9
16
*
TAB00
NOMESCO Finland
Lumbar puncture
6.9
14.6
24
39
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
53.8
13.0
15
*
N06AA09
ATC
amitriptyline; systemic
4.6
11.9
31
77
AA1AD
NOMESCO Finland
CT of head and brain
2.8
10.5
70
319
3529X
ICD-9 Finland
Disorders of other cranial nerves, Unspecified disorder of cranial nerves
+∞
10.5
10
*
R51.80
ICD-10 Finland
Headache
3.2
10.1
46
169
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.9
10.0
32
93
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
23.0
9.5
13
6
N03AE01
ATC
clonazepam; systemic
4.9
8.8
20
44
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.0
8.8
27
76
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.3
8.6
37
130
H53.2
ICD-10 Finland
Diplopia
6.9
7.9
19
30
ACC51
NOMESCO Finland
Release of median nerve
83.1
7.5
8
*
N02AX02
ATC
tramadol; systemic, rectal
2.3
7.4
93
554
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
7.8
7.4
16
22
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
6.9
101
635
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
6.9
79
450
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.8
6.6
21
60
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.2
6.6
28
97
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
10.6
6.6
12
12
L28
ICPC
Limited function/disability (L)
2.6
6.4
41
179
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
114
658
2.73
10.83
8.2
6.0
1.23
1.21
mmol/l
1.35
103
595
120
713
2.73
10.72
9.7
7.1
1.23
1.21
mmol/l
1.78
106
605
67
341
2.46
7.71
2.4
2.2
—
—
—
0
0
125
868
2.19
6.52
6.7
4.8
6.95
6.67
mmol/l
0.50
119
806
101
653
2.12
6.26
2.9
2.8
—
—
—
0
0
86
525
2.13
6.17
4.0
3.4
2.37
2.36
mmol/l
0.26
75
463
41
183
2.56
6.11
4.2
4.5
31.62
32.09
%
0.09
32
119
152
1162
2.33
5.98
9.7
7.1
82.43
77.20
u/l
0.49
143
1084
95
614
2.05
5.75
2.7
2.3
78.92
75.75
nmol/l
0.41
88
541
46
225
2.36
5.61
3.8
1.7
28.89
29.37
s
0.19
46
219
52
274
2.22
5.31
1.8
1.7
1038.24
1185.57
nmol/l
0.45
39
210
61
348
2.09
5.07
2.6
2.1
2.77
3.12
mg/l
0.63
48
295
89
586
1.94
4.91
2.4
1.9
98.61
94.68
pmol/l
0.27
49
281
102
704
1.93
4.88
14.9
13.6
1.23
1.31
inr
0.30
21
197
22
81
2.93
4.69
2.0
1.7
—
—
—
0
0
9
15
6.23
3.86
1.2
1.1
—
—
—
0
0
41
222
2.07
3.83
2.0
1.9
—
—
—
0
0
86
605
1.75
3.55
4.2
2.6
126.77
117.32
ug/l
0.22
76
556
9
17
5.49
3.55
1.2
1.1
—
—
—
0
0
36
192
2.07
3.49
7.2
5.9
1.04
1.03
mmol/l
0.07
31
173
23
103
2.40
3.38
1.8
1.6
—
—
—
0
0
30
151
2.16
3.37
11.6
10.3
1.48
1.08
mmol/l
0.19
23
115
112
861
1.69
3.26
10.9
9.4
4.14
4.04
e9/l
0.16
95
756
65
438
1.72
3.05
3.2
3.0
3464.23
1344.54
ng/l
0.89
56
380
18
76
2.51
2.99
1.6
1.2
—
—
—
0
0
7
13
5.54
2.89
1.3
1.0
—
—
—
0
0
29
153
2.05
2.89
1.8
1.7
—
—
—
0
0
53
344
1.74
2.81
1.6
1.6
25.34
21.66
nmol/l
0.62
43
286
43
264
1.80
2.75
4.4
3.3
56.66
135.45
ng/l
0.80
37
210
28
149
2.02
2.73
1.9
1.7
—
—
—
0
0
10
29
3.58
2.73
2.1
1.2
—
—
—
0
0
6
10
6.15
2.72
1.5
1.2
1.59
1.88
mmol/l
—
6
10
49
315
1.74
2.68
2.1
1.6
0.84
1.47
mg/l
1.27
43
250
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
12
41
3.05
2.67
1.7
2.5
0.27
0.34
u/ml
—
6
21
121
978
1.61
2.67
6.8
4.3
11.00
249.32
e6/l
—
5
22
6
11
5.59
2.56
1.0
1.1
—
—
—
0
0
39
238
1.80
2.54
4.7
2.5
0.76
0.84
e6/l
0.13
25
126
10
32
3.24
2.47
1.4
1.2
31.40
93.27
e6/l
—
10
26
170
1515
1.86
2.44
23.2
13.7
21.30
23.95
mg/l
0.50
149
1180
64
454
1.61
2.39
4.4
3.5
15.03
9.49
mg/mmol
0.46
46
289
76
562
1.57
2.38
5.3
3.7
56.58
36.38
ng/l
0.62
56
390
37
232
1.73
2.20
5.4
2.8
2.05
1.87
e6/l
0.06
22
121
130
1095
1.55
2.19
5.5
3.9
11.62
12.64
mm/h
0.35
121
1001
46
309
1.64
2.12
1.3
1.8
433.87
15810720.51
pmol/l
0.50
40
253
10
37
2.79
2.10
1.8
1.4
—
—
—
0
0
35
221
1.71
2.03
1.3
1.2
1.24
11.10
u/ml
1.10
13
83
45
304
1.62
2.02
1.5
1.2
6.33
1.39
u/ml
—
10
91
72
546
1.50
1.95
5.2
3.0
—
—
—
0
0
11
46
2.47
1.89
1.3
1.3
—
—
—
0
0
58
423
1.52
1.88
4.6
2.9
0.34
0.47
e6/l
0.26
48
306
36
236
1.64
1.82
1.4
1.3
10.30
36.05
iu/ml
—
10
69
118
1001
1.44
1.73
3.8
2.9
47.42
44.48
u/l
0.21
108
936
20
112
1.87
1.72
3.8
2.3
59.75
64.76
ml/min/173m2
—
8
51
15
76
2.05
1.69
18.3
10.1
94.37
94.68
%
0.10
15
76
5
14
3.63
1.62
1.4
1.1
—
—
—
0
0
8
32
2.56
1.61
1.4
1.4
214.63
303.19
mu/l
—
8
32
10
43
2.39
1.61
4.1
2.3
—
—
—
0
0
49
356
1.50
1.60
3.9
2.6
368.02
6077.42
umol/l
1.57
42
301
153
1374
1.50
1.59
6.2
4.5
1.77
1.95
mu/l
1.21
139
1230
12
57
2.18
1.58
2.5
1.9
—
—
—
0
0
14
71
2.05
1.58
1.1
1.1
—
—
—
0
0
128
1115
1.42
1.54
5.2
3.8
14.93
14.80
pmol/l
0.20
111
995
159
1443
1.52
1.53
20.0
13.0
80.97
79.79
ml/min/173m2
0.24
135
1173
6
21
2.91
1.51
1.3
7.5
—
198.80
—
0
5
27
174
1.64
1.47
13.1
6.5
104.00
104.25
mmol/l
0.07
27
174
6
22
2.78
1.44
1.3
1.5
—
—
—
0
0
6
22
2.78
1.44
1.3
1.5
—
—
—
0
0
6
22
2.78
1.44
1.3
1.5
—
—
—
0
0
6
22
2.78
1.44
1.3
1.5
—
—
—
0
0
6
22
2.78
1.44
1.3
1.5
—
—
—
0
0
9
40
2.31
1.42
1.1
1.8
—
—
—
0
0
9
41
2.25
1.39
8.8
1.8
—
—
—
0
0
6
23
2.66
1.38
1.3
1.5
—
—
—
0
0
11
56
2.02
1.24
2.0
1.3
—
—
—
0
0
11
58
1.95
1.14
2.7
2.3
—
—
—
0
0
173
1626
1.51
1.11
14.1
9.9
29.39
25.34
u/l
1.13
168
1565
154
1421
1.38
1.07
7.1
5.6
41.88
39.71
mmol/mol
1.37
138
1326
105
919
1.30
1.05
3.3
3.0
—
—
—
0
0
87
744
1.30
1.03
4.9
3.6
0.00
0.00
estimate
—
10
152
88
758
1.29
0.98
5.0
3.6
0.00
0.00
estimate
—
9
136
87
749
1.29
0.97
6.7
4.8
0.00
0.00
estimate
—
8
142
6
27
2.26
0.94
1.3
1.5
—
—
—
0
0
6
27
2.26
0.94
1.3
1.5
—
—
—
0
0
9
52
1.76
0.93
2.1
1.5
—
—
—
0
0
20
136
1.52
0.91
3.8
2.6
4.04
7.75
ug/l
0.91
15
119
178
1697
1.48
0.89
32.9
20.1
253.15
245.94
e9/l
0.82
172
1649
178
1699
1.47
0.86
33.8
20.1
39.21
40.22
%
1.19
168
1595
178
1699
1.47
0.86
32.9
20.1
4.43
4.48
e12/l
0.62
171
1646
8
46
1.77
0.83
1.6
1.5
—
—
—
0
0
11
66
1.71
0.80
8.4
3.7
25.17
24.80
mmol/l
0.19
11
66
6
33
1.84
0.79
1.2
1.4
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
7.28
—
0
19
32
247
1.35
0.77
1.9
1.5
—
—
—
0
0
5
28
1.81
0.66
1.6
1.4
—
—
—
0
0
8
49
1.66
0.63
1.0
1.2
—
—
—
0
0
8
49
1.66
0.63
1.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
155
1473
1.24
0.58
4.9
4.4
6.14
5.94
mmol/l
1.16
140
1349
6
36
1.69
0.57
1.8
1.4
—
—
—
0
0
36
302
1.23
0.49
2.8
3.0
0.93
0.85
ug/l
0.17
25
196
58
515
1.18
0.44
5.7
4.8
7.63
2.98
ug/l
0.74
53
470
21
167
1.29
0.44
6.4
7.2
—
—
—
0
0
5
31
1.63
0.43
1.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
181.04
—
0
17
0
18
0.00
0.40
0.0
1.1
—
115.33
—
0
18
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
159
1534
1.19
0.39
5.5
4.9
2.59
2.73
mmol/l
1.28
144
1410
5
36
1.40
0.38
3.0
2.3
141.00
125.81
g/l
—
5
26
6
42
1.44
0.36
1.5
1.1
—
—
—
0
0
46
409
1.16
0.35
4.9
4.3
24.12
21.72
%
0.69
32
194
150
1451
1.14
0.30
4.5
3.9
1.31
1.27
mmol/l
0.29
135
1330
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
5.9
—
37.62
—
0
14
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
98.21
—
0
14
0
14
0.00
0.20
0.0
1.3
—
9.00
—
0
14
10
81
1.25
0.19
1.0
1.3
—
—
—
0
0
16
139
1.16
0.17
1.6
1.7
—
—
—
0
0
153
1500
1.09
0.16
4.8
4.3
1.43
1.48
mmol/l
0.56
137
1381
56
591
0.93
0.15
5.7
3.6
—
—
—
0
0
15
134
1.13
0.11
1.6
2.3
—
—
—
0
0
153
1508
1.06
0.10
5.0
4.4
4.50
4.64
mmol/l
0.97
139
1401
16
145
1.11
0.09
2.9
3.4
—
—
—
0
0
13
117
1.12
0.08
1.5
2.3
—
—
—
0
0
40
415
0.95
0.06
6.0
3.8
0.00
0.00
estimate
—
8
139
23
222
1.04
0.02
1.7
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.4
—
—
—
0
0
5
56
0.89
-0.00
1.4
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
50
1.00
-0.00
1.4
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
6
68
0.88
-0.00
1.3
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
8.01
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_DISOTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DISOTHUNS | 1.896 [1.51, 2.38] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 486 females with G6_DISOTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DISOTHUNS | 1.575 [1.2, 2.06] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 418 males with G6_DISOTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_DISOTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.141% | 0.319% |
| 5 | 1.129% | 1.779% |
| 10 | 2.979% | 4.367% |
| 15 | 5.596% | 8.369% |
| 20 | 9.291% | 13.813% |
Relationships between endpoints
↥Index endpoint: G6_DISOTHUNS – Disorders of other and unspecified cranial nerves
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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