No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
195 |
4. Check minimum number of eventsNone |
195 |
5. Include endpointsNone |
195 |
6. Filter based on genotype QC (FinnGen only) |
195 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of other and unspecified cranial nerves
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1570 | 846 | 707 |
| Only index persons | 1256 | 694 | 562 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 52.04 | 52.68 | 50.94 |
| Only index persons | 49.33 | 50.00 | 48.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 195 | 100 | 95 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 47.26 | 43.03 | 51.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 172
- Matched controls
- 1721
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G52.8
ICD-10 Finland
Disorders of other specified cranial nerves
+∞
72.0
64
*
G52.9
ICD-10 Finland
Cranial nerve disorder, unspecified
+∞
59.9
54
*
35608
ICD-8 Finland
Other diseases of cranial nerves, Alterius nervi
+∞
30.1
28
*
G51.0
ICD-10 Finland
Bell palsy
+∞
18.0
17
*
35609
ICD-8 Finland
Other diseases of cranial nerves, Unspecified
+∞
14.8
14
*
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
+∞
12.6
12
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.5
12.6
30
47
3529X
ICD-9 Finland
Disorders of other cranial nerves, Unspecified disorder of cranial nerves
+∞
10.5
10
*
N03AX16
ATC
pregabalin; oral
3.5
10.3
55
203
TAB00
NOMESCO Finland
Lumbar puncture
8.9
9.7
20
25
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
52.7
8.8
10
*
AA1AD
NOMESCO Finland
CT of head and brain
3.0
8.4
55
230
R51.80
ICD-10 Finland
Headache
3.8
8.2
36
112
ACC51
NOMESCO Finland
Release of median nerve
83.4
7.5
8
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
11.6
6.9
12
11
H53.2
ICD-10 Finland
Diplopia
9.3
6.7
13
15
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
7.9
6.6
14
19
N06AA09
ATC
amitriptyline; systemic
3.6
6.5
29
91
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.3
6.3
22
56
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
112
647
2.72
10.61
8.3
5.9
1.2
1.2
mmol/l
1.21
101
579
118
700
2.74
10.59
9.8
7.0
1.2
1.2
mmol/l
1.62
104
586
65
337
2.39
7.13
2.4
2.2
—
—
—
0
0
85
515
2.15
6.27
4.1
3.4
2.4
2.4
mmol/l
0.26
74
452
41
181
2.60
6.26
4.2
4.4
31.6
32.4
%
0.14
32
114
112
755
2.14
6.25
6.8
6.2
10.3
11.2
umol/l
0.71
107
712
122
851
2.16
6.21
6.8
4.7
6.8
6.6
mmol/l
0.27
116
788
99
646
2.08
5.92
4.4
4.5
—
—
—
0
0
94
605
2.07
5.80
2.7
2.3
78.8
76.1
nmol/l
0.33
87
531
45
216
2.41
5.74
3.8
1.7
28.9
29.4
s
0.16
45
210
149
1143
2.29
5.72
9.7
7.0
82.0
77.2
u/l
0.42
139
1063
52
269
2.27
5.58
1.8
1.7
1038.2
1193.2
nmol/l
0.48
39
205
60
346
2.06
4.83
2.6
2.0
2.7
3.1
mg/l
0.64
47
293
88
583
1.93
4.75
2.4
1.9
98.6
94.3
pmol/l
0.30
49
278
22
81
2.93
4.70
2.0
1.7
—
—
—
0
0
36
190
2.10
3.60
7.2
5.9
1.0
1.0
mmol/l
0.10
31
172
85
598
1.75
3.52
4.1
2.6
123.9
117.3
ug/l
0.14
75
549
8
14
5.91
3.37
1.3
1.1
—
—
—
0
0
29
147
2.14
3.20
12.0
10.3
1.5
1.1
mmol/l
0.18
22
111
39
221
1.96
3.20
2.1
1.9
—
—
—
0
0
110
847
1.69
3.17
11.0
9.4
4.1
4.1
e9/l
0.08
93
739
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
12
39
3.21
3.15
1.7
2.6
0.3
0.4
u/ml
—
6
20
64
428
1.74
3.10
3.2
2.9
3525.2
1364.1
ng/l
0.89
55
368
8
16
5.16
3.08
1.3
1.1
—
—
—
0
0
22
102
2.30
3.00
1.9
1.6
—
—
—
0
0
5
5
10.21
2.99
1.6
1.2
—
—
—
0
0
53
340
1.77
2.95
1.6
1.6
25.3
21.7
nmol/l
0.61
43
283
43
260
1.84
2.90
4.4
3.3
56.7
127.3
ng/l
0.69
37
208
17
74
2.42
2.66
1.6
1.2
—
—
—
0
0
28
152
1.98
2.59
1.9
1.7
—
—
—
0
0
6
11
5.59
2.56
1.0
1.1
—
—
—
0
0
6
11
5.59
2.56
1.5
1.2
1.6
1.8
mmol/l
—
6
11
48
311
1.72
2.56
2.1
1.6
0.8
1.5
mg/l
1.29
43
247
27
148
1.96
2.44
1.9
1.7
—
—
—
0
0
75
554
1.57
2.37
5.1
3.7
57.4
36.7
ng/l
0.63
55
380
167
1493
1.83
2.29
23.0
13.7
21.6
24.3
mg/l
0.49
146
1160
6
13
4.72
2.29
1.3
1.0
—
—
—
0
0
118
971
1.55
2.26
6.8
4.3
11.0
249.3
e6/l
—
5
22
45
302
1.64
2.08
1.4
1.8
436.9
16194776.4
pmol/l
0.50
39
247
37
236
1.70
2.07
4.8
2.5
0.8
0.8
e6/l
0.14
24
121
10
38
2.72
2.04
1.8
1.4
—
—
—
0
0
10
38
2.72
2.04
4.1
2.5
—
—
—
0
0
9
32
2.90
2.03
1.4
1.2
34.6
95.5
e6/l
—
9
25
36
232
1.68
1.94
5.5
2.8
2.0
1.9
e6/l
0.05
22
118
127
1084
1.49
1.89
5.4
3.8
11.7
12.6
mm/h
0.33
118
989
11
46
2.47
1.89
1.3
1.3
—
—
—
0
0
8
29
2.83
1.81
1.5
1.2
—
—
—
0
0
34
221
1.65
1.78
1.3
1.2
1.2
11.4
u/ml
1.09
12
80
6
19
3.22
1.67
1.3
7.9
—
198.8
—
0
5
12
56
2.22
1.65
2.5
1.9
—
—
—
0
0
43
302
1.54
1.64
1.5
1.2
6.3
1.4
u/ml
—
10
89
115
980
1.42
1.61
3.8
2.8
47.4
44.1
u/l
0.24
105
913
35
238
1.57
1.54
1.4
1.3
10.3
37.2
iu/ml
—
10
68
5
15
3.39
1.53
1.4
1.2
—
—
—
0
0
19
109
1.82
1.53
4.1
2.3
59.8
65.4
ml/min/173m2
—
8
48
14
72
2.02
1.53
1.1
1.0
—
—
—
0
0
14
72
2.02
1.53
19.5
10.2
94.4
94.7
%
0.09
14
72
6
21
2.91
1.51
1.3
1.6
—
—
—
0
0
6
21
2.91
1.51
1.3
1.6
—
—
—
0
0
6
21
2.91
1.51
1.3
1.6
—
—
—
0
0
6
21
2.91
1.51
1.3
1.6
—
—
—
0
0
6
21
2.91
1.51
1.3
1.6
—
—
—
0
0
150
1350
1.48
1.50
6.2
4.4
1.8
2.0
mu/l
1.26
136
1204
69
543
1.42
1.49
5.3
3.0
—
—
—
0
0
156
1417
1.50
1.47
20.0
12.9
81.2
79.8
ml/min/173m2
0.28
131
1145
48
354
1.47
1.46
3.9
2.6
372.6
8103.8
umol/l
1.76
40
295
9
39
2.37
1.45
1.1
1.8
—
—
—
0
0
6
22
2.78
1.44
1.3
1.5
—
—
—
0
0
125
1094
1.40
1.42
5.2
3.7
14.9
14.8
pmol/l
0.21
108
973
11
53
2.14
1.41
2.0
1.3
—
—
—
0
0
7
29
2.46
1.40
1.0
1.5
202.1
308.5
mu/l
—
7
29
9
41
2.25
1.39
10.0
1.8
—
—
—
0
0
26
170
1.61
1.34
13.5
6.4
103.8
104.2
mmol/l
0.14
26
165
55
424
1.41
1.32
4.7
2.9
0.4
0.5
e6/l
0.21
45
302
11
57
1.99
1.19
2.7
2.3
—
—
—
0
0
170
1599
1.49
1.06
14.1
9.8
28.8
25.3
u/l
0.92
165
1538
11
60
1.88
1.05
3.8
4.0
23.4
24.3
mmol/l
0.25
11
54
151
1397
1.36
0.99
7.1
5.6
41.8
39.7
mmol/mol
1.28
135
1301
6
27
2.26
0.94
1.3
1.5
—
—
—
0
0
6
27
2.26
0.94
1.3
1.5
—
—
—
0
0
11
64
1.76
0.88
8.4
3.7
25.2
24.8
mmol/l
0.17
11
64
19
129
1.52
0.87
3.4
2.5
4.2
8.0
ug/l
0.88
14
113
102
906
1.26
0.86
3.4
3.0
—
—
—
0
0
32
242
1.39
0.86
1.9
1.5
—
—
—
0
0
6
32
1.90
0.82
1.2
1.4
—
—
—
0
0
9
53
1.73
0.76
2.1
1.5
—
—
—
0
0
85
750
1.24
0.73
5.0
3.6
0.0
0.0
estimate
—
8
135
84
741
1.23
0.72
6.8
4.8
0.0
0.0
estimate
—
7
141
83
732
1.23
0.71
4.9
3.6
0.0
0.0
estimate
—
5
139
5
26
1.95
0.71
1.6
1.3
—
—
—
0
0
17
120
1.46
0.67
16.3
11.9
116.4
118.5
g/l
0.16
17
115
10
62
1.65
0.66
6.4
2.5
1.3
1.1
%
—
10
62
7
44
1.61
0.66
1.7
1.5
—
—
—
0
0
8
49
1.66
0.63
1.0
1.2
—
—
—
0
0
8
49
1.66
0.63
1.0
1.2
—
—
—
0
0
5
30
1.68
0.62
1.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
7.6
—
0
16
6
37
1.64
0.56
1.8
1.4
—
—
—
0
0
21
162
1.33
0.52
6.4
6.9
—
—
—
0
0
152
1449
1.22
0.52
4.8
4.4
6.1
5.9
mmol/l
1.13
137
1323
35
294
1.23
0.47
2.8
3.1
1.0
0.9
ug/l
0.23
24
192
144
1371
1.19
0.47
24.7
14.7
38.8
40.1
%
0.94
102
1005
57
505
1.18
0.45
5.7
4.9
7.8
3.0
ug/l
0.74
52
458
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
115.3
—
0
18
6
41
1.48
0.36
1.5
1.1
—
—
—
0
0
45
399
1.17
0.35
4.8
4.4
24.1
21.6
%
0.73
32
193
156
1509
1.17
0.34
5.4
4.8
2.6
2.7
mmol/l
1.25
141
1383
147
1425
1.13
0.27
4.5
3.9
1.3
1.3
mmol/l
0.22
132
1303
54
580
0.90
0.22
5.7
3.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
10
80
1.26
0.21
1.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
3.9
—
34.4
—
0
13
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
16
136
1.19
0.21
1.6
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
9.0
—
0
14
0
14
0.00
0.20
0.0
1.1
—
98.2
—
0
14
38
410
0.91
0.17
6.0
3.8
0.0
0.0
estimate
—
7
138
150
1474
1.08
0.13
4.8
4.3
1.4
1.5
mmol/l
0.45
134
1353
16
144
1.12
0.11
2.9
3.4
—
—
—
0
0
150
1481
1.06
0.08
5.0
4.4
4.5
4.6
mmol/l
0.88
136
1372
14
128
1.10
0.07
1.6
2.4
—
—
—
0
0
12
112
1.08
0.03
1.6
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
8.0
—
0
6
6
67
0.89
0.00
1.5
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
22
220
1.00
0.00
1.8
1.4
—
—
—
0
0
5
52
0.96
0.00
1.4
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
5
54
0.92
0.00
1.4
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
4.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_DISOTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DISOTHUNS | 1.896 [1.51, 2.38] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 486 females with G6_DISOTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DISOTHUNS | 1.575 [1.2, 2.06] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 418 males with G6_DISOTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_DISOTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.141% | 0.319% |
| 5 | 1.129% | 1.779% |
| 10 | 2.979% | 4.367% |
| 15 | 5.596% | 8.369% |
| 20 | 9.291% | 13.813% |
Relationships between endpoints
↥Index endpoint: G6_DISOTHUNS – Disorders of other and unspecified cranial nerves
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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