No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
195 |
4. Check minimum number of eventsNone |
195 |
5. Include endpointsNone |
195 |
6. Filter based on genotype QC (FinnGen only) |
195 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of other and unspecified cranial nerves
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1570 | 846 | 707 |
| Only index persons | 1256 | 694 | 562 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 52.04 | 52.68 | 50.94 |
| Only index persons | 49.33 | 50.00 | 48.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 195 | 100 | 95 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 47.26 | 43.03 | 51.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 172
- Matched controls
- 1721
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G52.8
ICD-10 Finland
Disorders of other specified cranial nerves
+∞
72.0
64
*
G52.9
ICD-10 Finland
Cranial nerve disorder, unspecified
+∞
59.9
54
*
35608
ICD-8 Finland
Other diseases of cranial nerves, Alterius nervi
+∞
30.1
28
*
G51.0
ICD-10 Finland
Bell palsy
+∞
18.0
17
*
35609
ICD-8 Finland
Other diseases of cranial nerves, Unspecified
+∞
14.8
14
*
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
+∞
12.6
12
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.5
12.6
30
47
3529X
ICD-9 Finland
Disorders of other cranial nerves, Unspecified disorder of cranial nerves
+∞
10.5
10
*
N03AX16
ATC
pregabalin; oral
3.5
10.3
55
203
TAB00
NOMESCO Finland
Lumbar puncture
8.9
9.7
20
25
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
52.7
8.8
10
*
AA1AD
NOMESCO Finland
CT of head and brain
3.0
8.4
55
230
R51.80
ICD-10 Finland
Headache
3.8
8.2
36
112
ACC51
NOMESCO Finland
Release of median nerve
83.4
7.5
8
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
11.6
6.9
12
11
H53.2
ICD-10 Finland
Diplopia
9.3
6.7
13
15
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
7.9
6.6
14
19
N06AA09
ATC
amitriptyline; systemic
3.6
6.5
29
91
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.3
6.3
22
56
Mortality – FinRegistry
↥Association
Association between endpoint G6_DISOTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DISOTHUNS | 1.896 [1.51, 2.38] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 486 females with G6_DISOTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DISOTHUNS | 1.575 [1.2, 2.06] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 418 males with G6_DISOTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_DISOTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.141% | 0.319% |
| 5 | 1.129% | 1.779% |
| 10 | 2.979% | 4.367% |
| 15 | 5.596% | 8.369% |
| 20 | 9.291% | 13.813% |
Relationships between endpoints
↥Index endpoint: G6_DISOTHUNS – Disorders of other and unspecified cranial nerves
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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