Vitreous prolapse

H7_VITRPROLAPSE

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H43.0 Cause of death: ICD-10 — H43.0 2 out of 7 registries used, show all original rules.	88
4. Check minimum number of events None	88
5. Include endpoints None	88
6. Filter based on genotype QC (FinnGen only)	88

Control definitions (FinnGen only)

Control exclude: H7_VITREOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H43
Name in latin: Prolapsus corporis vitrei

NAME	H7_VITRPROLAPSE
CONTROL_EXCLUDE	H7_VITREOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H430
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H430
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Vitreous prolapse based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	559	343	212
Only index persons	534	334	200
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	63.03	63.47	62.46
Only index persons	62.75	63.45	61.58

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	88	59	29
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	59.65	57.86	63.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
78: Matched controls
779

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H43.0

ICD-10 Finland

Vitreous prolapse

+∞

112.2

H43.8

ICD-10 Finland

Other disorders of vitreous body

120.3

24.3

H43.1

ICD-10 Finland

Vitreous haemorrhage

+∞

19.6

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

5.1

9.6

117

S01ED01

ATC

timolol; ophthalmic

15.2

8.8

H3603, E103

ICD-10 Finland

100.5

8.6

CKD65

NOMESCO Finland

Pars plana or pars plicata vitrectomy

25.2

8.3

H33.0

ICD-10 Finland

Retinal detachment with retinal break

25.2

8.3

CJB10

NOMESCO Finland

Laser discission of secondary cataract

8.0

7.6

CKC10

NOMESCO Finland

Local photocoagulation of retina

88.1

7.6

CKD40

NOMESCO Finland

Endophotocoagulation of retina

88.1

7.6

Z96.1

ICD-10 Finland

Presence of intraocular lens

5.9

7.3

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

3.7

6.9

181

H26.4

ICD-10 Finland

After-cataract

6.5

6.6

H33.3

ICD-10 Finland

Retinal breaks without detachment

16.7

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3026782) Osmolality of Urine

153

2.72

4.53

2.6

2.7

573.2

560.7

mosm/kgh2o

0.09

129

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.35

3.60

1.6

1.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

4.43

2.97

1.4

1.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

385

2.14

2.95

10.5

6.4

1.2

mmol/l

0.38

327

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

283

2.11

2.95

5.9

3.2

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

6.34

2.74

1.2

1.3

—

(3012544) pH of Venous blood

2.50

2.57

7.4

4.2

—

(3000850) Epithelial cells [#/volume] in Urine

168

2.08

2.49

4.5

2.6

12.7

4.3

e6/l

0.68

148

(3013512) EKG study

227

1.99

2.45

4.9

4.0

—

(3000330) Specific gravity of Urine by Test strip

2.92

2.38

3.2

3.9

—

(42870588) Differential panel, method unspecified - Blood

229

1.97

2.37

6.9

5.4

—

(3030467) Casts [#/volume] in Urine by Automated count

229

1.97

2.37

4.1

3.0

0.4

0.5

e6/l

0.25

169

(3020682) Albumin/Creatinine [Ratio] in Urine

247

1.95

2.35

6.8

4.1

3.4

10.0

mg/mmol

1.48

150

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

4.13

2.30

1.3

1.2

0.3

0.2

g/l

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

244

1.89

2.16

3.3

2.4

65.6

55.0

u/l

0.35

224

(3002582) Erythrocytes [#/volume] in Urine

245

1.88

2.12

5.6

3.2

32.6

52.6

e6/l

0.34

182

(3018418) pH of Serum or Plasma

245

1.88

2.12

10.9

4.7

7.4

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

3.71

2.10

1.3

1.2

1.1

1.2

g/l

—

(36304419) Bacteria [Presence] in Urine

221

1.88

2.05

4.2

2.9

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

450

1.85

1.95

10.5

10.4

4.0

4.1

e9/l

0.04

398

(3006315) Basophils [#/volume] in Blood

362

1.80

1.93

8.5

6.0

0.0

e9/l

0.14

318

(3007853) Bacteria identified in Skin by Aerobe culture

2.16

1.84

2.1

1.7

—

(3009508) Creatinine [Moles/volume] in Urine

240

1.76

1.73

5.5

3.1

6.8

7.1

mmol/l

0.20

200

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

351

1.73

1.72

13.5

5.8

1.2

mmol/l

0.68

320

(3018095) Leukocytes [#/volume] in Urine

278

1.72

1.68

6.5

3.6

104.7

90.7

e6/l

0.07

194

(3001604) Monocytes [#/volume] in Blood

363

1.71

1.66

8.7

6.0

0.5

0.6

e9/l

0.53

317

(3000991) Gas panel - Venous blood

2.21

1.64

11.0

7.4

—

(4094501)

3.72

1.64

1.2

1.1

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

433

1.72

1.63

5.1

6.9

9.8

10.8

umol/l

0.54

408

(40768797) Stomach Pathology biopsy report

117

1.92

1.62

1.5

1.2

—

(3019069) Monocytes/100 leukocytes in Blood

336

1.69

1.62

9.2

6.1

8.1

8.4

0.41

317

(3052851) Hemolysis interference index of Serum or Plasma

2.83

1.61

2.4

3.2

—

(3021589) Normoblasts [#/volume] in Blood

338

1.68

1.57

12.4

10.7

0.0

e9/l

0.50

281

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

617

1.92

1.54

9.2

7.8

79.6

79.2

u/l

0.03

575

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

3.47

1.54

1.6

3.4

267.2

170.7

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.47

1.54

1.4

1.1

—

(3026008) Bacteria identified in Urine by Culture

229

1.71

1.54

3.7

2.7

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

152

1.80

1.53

1.7

1.6

1.1

mg/l

0.21

119

(3022096) Basophils/100 leukocytes in Blood

321

1.66

1.52

9.5

5.9

0.7

0.07

299

(3012516) Albumin [Mass/volume] in Urine

231

1.69

1.48

5.8

3.3

29.5

343.5

mg/l

0.58

146

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.93

1.48

2.3

1.9

—

(3006504) Eosinophils/100 leukocytes in Blood

333

1.64

1.46

9.2

5.9

2.5

2.8

0.40

311

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

749

2.39

1.43

6.0

4.6

4.7

mmol/l

0.21

689

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.33

1.42

3.2

2.9

0.7

—

(3002030) Lymphocytes/100 leukocytes in Blood

345

1.62

1.41

9.2

6.0

26.3

28.9

0.89

323

(1761482) Bacteria [#/volume] in Urine by Culture

2.72

1.39

3.7

4.7

—

(3019198) Lymphocytes [#/volume] in Blood

375

1.62

1.38

8.7

6.0

1.7

2.3

e9/l

1.07

334

(3024928) Oxygen saturation in Venous blood

3.05

1.38

1.2

3.5

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.22

1.35

3.2

2.8

1.1

1.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.61

1.33

2.3

2.7

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.88

1.30

1.4

2.3

94.2

91.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.88

1.30

1.4

1.1

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.50

1.26

1.3

1.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

305

1.57

1.24

2.0

1.9

100.3

97.4

pmol/l

0.09

145

(3018010) Neutrophils/100 leukocytes in Blood

343

1.57

1.24

9.2

5.8

59.2

56.4

0.61

324

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.10

1.15

1.8

1.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

721

1.93

1.12

5.2

4.1

1.2

1.3

mmol/l

0.07

656

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

583

1.63

1.11

5.2

4.0

14.5

14.9

pmol/l

0.59

517

(36660697) Celiac disease serology panel - Serum

1.92

1.11

1.2

1.1

—

(4034850)

2.29

1.11

11.9

9.5

—

(3032080) INR in Blood by Coagulation assay

321

1.52

1.10

6.5

8.5

1.1

1.2

inr

—

108

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.86

1.10

2.8

2.1

0.2

g/l

0.07

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

745

2.10

1.10

5.9

4.6

1.5

mmol/l

0.02

681

(1761868) Lipid panel - Serum or Plasma

256

1.53

1.09

4.1

3.0

—

(40768804) Tissue Pathology biopsy report

325

1.49

1.02

2.4

2.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.81

1.02

2.3

1.7

—

(40768793) Breast Pathology biopsy report

0.00

0.99

0.0

1.3

—

(3000492) Spirometry study

1.92

0.96

1.3

1.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

112

1.64

0.93

2.1

1.8

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.22

0.93

1.0

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

227

1.49

0.92

1.6

1.2

1.3

mmol/l

0.09

193

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.99

0.91

1.8

1.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

766

2.03

0.90

6.7

5.3

2.7

mmol/l

0.17

702

(3049717) Cytology report of Urine Cyto stain

2.07

0.89

1.7

3.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

534

1.46

0.85

5.6

3.9

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.81

0.85

2.1

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.69

0.83

2.3

1.8

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.82

0.83

1.2

1.4

—

(3026493) Urate [Moles/volume] in Serum or Plasma

204

1.47

0.83

5.1

3.2

399.2

6642.7

umol/l

1.30

170

(3019060) Gas panel - Arterial blood

1.73

0.81

3.3

4.3

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

233

1.44

0.80

1.8

1.9

116.1

173.4

u/l

0.87

215

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.24

0.77

1.2

2.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.71

0.76

5.1

2.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

369

1.38

0.75

5.0

4.1

—

(3023368) Bacteria identified in Blood by Culture

200

1.43

0.72

8.8

4.1

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.72

0.70

1.4

1.5

—

(3007164) IgA [Mass/volume] in Serum or Plasma

174

1.44

0.69

2.5

1.4

2.3

2.8

g/l

0.57

107

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

184

1.42

0.67

1.3

1.2

0.8

0.9

u/ml

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.69

0.64

7.0

6.9

95.2

95.0

—

(3002256) Pathology report gross observation

1.53

0.64

1.4

1.2

—

(3025941) Bacteria identified in Stool by Culture

1.66

0.63

1.5

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

406

1.34

0.63

4.8

3.7

0.0

estimate

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

303

1.32

0.56

5.0

3.5

26.0

36.3

ng/l

0.58

208

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.62

0.55

6.8

7.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.54

0.52

2.8

2.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

287

1.30

0.52

3.6

3.2

2.4

mmol/l

0.51

250

(3044889) 12 lead EKG panel

546

1.31

0.51

4.5

4.0

—

(40758558) Short blood count panel - Blood

212

1.32

0.50

5.7

7.8

—

(3021601) Nitrite [Presence] in Urine by Test strip

406

1.28

0.49

6.7

4.9

0.0

estimate

—

(3041096) Erythrocytes [Presence] in Urine by Automated

225

1.29

0.44

4.3

3.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

123

1.37

0.44

1.9

1.5

—

(3042936) Bacteria identified in Isolate by Culture

123

1.37

0.44

4.2

1.8

—

(3045414) Leukocytes [Presence] in Urine

1.60

0.43

1.4

1.8

—

(40768443) Skin Pathology biopsy report

1.60

0.43

1.4

1.2

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.41

0.0

2.7

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

227

1.27

0.41

4.9

2.8

3010.7

1014.1

ng/l

0.67

196

(3029937) Albumin [Presence] in Urine by Test strip

243

0.77

0.41

6.4

4.0

0.0

estimate

—

(3044640) Blood type and Crossmatch panel - Blood

237

1.27

0.41

3.6

2.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

735

1.38

0.38

24.1

13.5

72.3

79.7

ml/min/173m2

1.91

588

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

703

1.33

0.38

6.6

4.8

1.7

1.9

mu/l

0.62

633

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

173

1.28

0.37

3.2

2.1

—

(4035726)

0.61

0.37

1.8

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.50

0.37

1.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.39

0.36

2.6

1.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.42

0.36

1.2

2.0

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

726

1.34

0.35

9.4

5.7

41.9

40.1

mmol/mol

0.77

670

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

748

1.38

0.35

5.9

4.8

6.2

6.0

mmol/l

0.74

685

(3022145) Colonoscopy Study observation

101

1.34

0.34

1.4

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

168

1.25

0.30

10.6

6.5

—

(40761535) Cells panel - Urine sediment

1.30

0.27

6.0

3.5

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

495

1.18

0.26

2.8

34.4

45.6

u/l

1.44

459

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.22

0.26

3.2

1.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.20

0.25

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

144

1.22

0.24

1.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

135

1.23

0.23

1.4

1.2

16.0

36.5

iu/ml

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

756

1.28

0.23

26.5

14.2

24.1

22.3

mg/l

0.20

597

(3000494) Fungus identified in Specimen by Culture

1.27

0.22

1.3

1.4

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.1

—

16.6

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.1

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.21

0.0

1.4

—

1.4

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.2

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.20

0.0

1.6

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.19

0.20

2.0

2.8

505.7

172.3

ng/l

—

(3009542) Hematocrit [Volume Fraction] of Blood

675

1.18

0.20

23.2

14.6

40.0

39.5

0.25

466

(3019225) pH of Specimen

1.16

0.18

3.6

4.3

—

(4010399)

0.74

0.17

1.4

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

814

1.35

0.17

14.5

11.1

22.6

24.1

u/l

0.94

783

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

130

1.19

0.17

1.5

1.3

41.2

7.1

u/ml

—

(40761511) CBC panel - Blood by Automated count

795

1.24

0.15

22.3

12.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

327

1.12

0.15

5.2

3.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.21

0.14

4.0

3.5

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

126

0.85

0.12

3.1

3.3

1.0

0.7

ug/l

—

(3003694) ABO and Rh group [Type] in Blood

202

1.12

0.12

1.2

1.4

—

(40761536) Microorganisms panel - Urine sediment

1.09

0.08

3.5

3.6

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

1.14

0.07

3.1

5.5

234.6

251.8

u/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

109

1.12

0.06

9.9

7.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

448

1.06

0.05

3.6

2.6

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.11

0.04

6.7

4.7

29.6

32.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

171

1.07

0.03

4.6

24.0

21.0

0.61

101

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.0

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1736.6

—

(4268621)

0.00

0.0

1.7

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

0.9

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.5

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.4

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.4

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

2.6

—

156.6

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.4

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.5

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.2

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.5

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

4.0

—

4.6

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

190

1.00

0.00

5.6

3.8

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.2

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.5

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.5

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(44790049)

0.00

0.0

2.2

—

(44806118)

0.00

0.0

2.2

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

5.6

—

(4027681)

0.00

0.0

1.1

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.2

—

91.1

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

5.8

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.90

0.00

1.4

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.5

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

2.2

—

15.9

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.7

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.2

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3014037) CD3+CD4+ (T4 helper) cells/100 cells in Blood

0.00

0.0

1.8

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.2

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.1

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.8

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

5.4

—

0.6

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

295.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.2

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.5

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3022621) pH of Urine by Test strip

0.85

0.00

1.4

2.1

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.8

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

3.2

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.2

—

(44790048)

0.00

0.0

2.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.1

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.2

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

3.3

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(44790047)

0.00

0.0

2.2

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.3

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.2

—

168.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_VITRPROLAPSE and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_VITRPROLAPSE	1.037 [0.8, 1.35]	0.788
Birth year	0.997 [0.99, 1.01]	0.478

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 299 females with H7_VITRPROLAPSE died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_VITRPROLAPSE.

N-year risk	Females	Males
1	0.133%	No data
5	0.737%	No data
10	1.708%	No data
15	3.248%	No data
20	5.587%	No data

Relationships between endpoints

↥

Index endpoint: H7_VITRPROLAPSE – Vitreous prolapse

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Vitreous prolapse

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints