Vitreous prolapse

H7_VITRPROLAPSE

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H43.0 Cause of death: ICD-10 — H43.0 2 out of 7 registries used, show all original rules.	93
4. Check minimum number of events None	93
5. Include endpoints None	93
6. Filter based on genotype QC (FinnGen only)	91

Control definitions (FinnGen only)

Control exclude: H7_VITREOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H43
Name in latin: Prolapsus corporis vitrei

NAME	H7_VITRPROLAPSE
CONTROL_EXCLUDE	H7_VITREOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H430
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H430
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Vitreous prolapse based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	559	343	212
Only index persons	534	334	200
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	63.03	63.47	62.46
Only index persons	62.75	63.45	61.58

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	91	63	28
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	60.26	58.67	63.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
93: Matched controls
930

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H43.0

ICD-10 Finland

Vitreous prolapse

+∞

132.0

H43.8

ICD-10 Finland

Other disorders of vitreous body

57.0

27.0

H43.1

ICD-10 Finland

Vitreous haemorrhage

+∞

19.4

H26.4

ICD-10 Finland

After-cataract

6.9

12.9

CJB10

NOMESCO Finland

Laser discission of secondary cataract

6.6

10.9

CKD65

NOMESCO Finland

Pars plana or pars plicata vitrectomy

21.3

9.2

CKC12

NOMESCO Finland

Photocoagulation of retina

14.7

8.7

H33.0

ICD-10 Finland

Retinal detachment with retinal break

17.0

8.0

H3603, E103,

ICD-10 Finland

49.3

7.9

Z96.1

ICD-10 Finland

Presence of intraocular lens

4.1

7.6

S01ED51

ATC

timolol, combinations; ophthalmic

7.2

S01ED01

ATC

timolol; ophthalmic

10.6

7.1

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic

3.1

6.8

252

CKD40

NOMESCO Finland

Endophotocoagulation of retina

24.6

6.8

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

3.1

6.5

211

XCW99

NOMESCO Finland

Other investigative procedure of eye

4.2

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3026782) Osmolality of Urine

156

2.73

4.75

2.8

3.0

552.17

548.09

mosm/kgh2o

0.03

134

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.26

3.47

1.6

1.4

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.63

3.46

6.5

6.3

104.73

103.62

mmol/l

0.52

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

144

2.35

3.25

3.2

2.7

1.65

1.51

e6/l

0.07

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

4.86

3.20

1.6

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

293

2.04

2.84

5.7

3.2

—

(3000850) Epithelial cells [#/volume] in Urine

169

2.14

2.76

4.4

2.6

12.25

5.43

e6/l

0.54

152

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

400

2.01

2.67

10.4

6.3

1.23

1.22

mmol/l

0.39

344

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

5.74

2.58

1.2

1.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

129

2.16

2.46

3.5

2.8

2.87

3.31

e6/l

0.12

(3030467) Casts [#/volume] in Urine by Automated count

234

1.97

2.46

4.1

2.9

0.35

0.49

e6/l

0.32

172

(3020682) Albumin/Creatinine [Ratio] in Urine

257

1.89

2.26

6.4

3.8

3.30

10.51

mg/mmol

1.74

154

(3002582) Erythrocytes [#/volume] in Urine

249

1.89

2.24

5.6

3.1

32.95

54.90

e6/l

0.39

184

(3000330) Specific gravity of Urine by Test strip

2.83

2.23

3.2

3.9

—

(36304419) Bacteria [Presence] in Urine

225

1.89

2.18

4.2

2.8

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

159

1.98

2.16

1.7

1.45

1.09

mg/l

0.16

125

(40768797) Stomach Pathology biopsy report

120

2.09

2.16

1.4

1.2

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

3.52

2.01

1.3

1.2

0.25

0.23

g/l

—

(3000991) Gas panel - Venous blood

2.28

1.87

10.9

7.3

—

(3006315) Basophils [#/volume] in Blood

382

1.74

1.85

8.2

5.8

0.04

e9/l

0.05

338

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

3.20

1.84

1.3

1.2

1.07

1.21

g/l

—

(3001604) Monocytes [#/volume] in Blood

383

1.73

1.82

8.2

5.7

0.54

0.56

e9/l

0.36

339

(3013650) Neutrophils [#/volume] in Blood by Automated count

472

1.76

1.81

10.2

4.05

4.02

e9/l

0.03

417

(3013115) Eosinophils [#/volume] in Blood

393

1.73

1.81

8.3

5.9

0.19

0.18

e9/l

0.05

356

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

254

1.76

1.81

3.3

2.5

66.13

54.76

u/l

0.38

233

(3019069) Monocytes/100 leukocytes in Blood

356

1.72

1.78

8.7

5.7

7.91

8.44

0.62

337

(3018095) Leukocytes [#/volume] in Urine

283

1.73

1.75

6.5

3.6

104.73

104.01

e6/l

0.00

196

(40760892) CBC W Ordered Manual Differential panel - Blood

358

1.70

1.73

9.6

6.5

—

(3013512) EKG study

240

1.73

1.70

5.0

4.0

—

(3052851) Hemolysis interference index of Serum or Plasma

2.94

1.68

2.3

3.2

—

(3009508) Creatinine [Moles/volume] in Urine

250

1.72

1.67

5.4

3.0

6.97

7.11

mmol/l

0.08

208

(3006504) Eosinophils/100 leukocytes in Blood

353

1.67

1.62

8.7

5.4

2.43

2.86

0.62

333

(3018418) pH of Serum or Plasma

253

1.69

1.59

11.2

4.6

7.39

7.41

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.01

1.58

2.1

1.7

—

(3021589) Normoblasts [#/volume] in Blood

355

1.65

1.57

11.9

10.1

0.00

0.01

e9/l

0.50

296

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

453

1.67

1.56

4.9

6.6

9.63

10.88

umol/l

0.71

427

(3028626) Oxygen [Partial pressure] in Capillary blood

3.46

1.54

4.2

1.9

8.60

8.15

kpa

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.46

1.54

1.4

1.1

—

(3002030) Lymphocytes/100 leukocytes in Blood

366

1.64

1.54

8.7

5.6

26.24

28.60

0.88

348

(3022096) Basophils/100 leukocytes in Blood

339

1.63

1.51

9.1

5.4

0.68

0.01

317

(3019198) Lymphocytes [#/volume] in Blood

397

1.63

1.49

8.2

5.7

1.71

2.17

e9/l

0.88

361

(3012516) Albumin [Mass/volume] in Urine

239

1.67

1.48

5.6

3.2

28.40

345.39

mg/l

0.59

147

(3026008) Bacteria identified in Urine by Culture

239

1.67

1.48

3.8

2.6

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

145

1.78

1.47

3.3

3.5

47.65

213.01

ng/l

0.74

113

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

3.24

1.45

1.6

3.9

267.20

171.81

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

362

1.60

1.41

13.7

5.7

1.23

1.21

mmol/l

0.70

335

(3018010) Neutrophils/100 leukocytes in Blood

363

1.60

1.39

8.7

5.4

59.47

56.67

0.65

345

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.26

1.38

3.2

2.8

0.69

0.70

—

(4034850) Laboratory test

2.48

1.33

10.8

9.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.60

1.32

3.7

4.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

319

1.58

1.32

2.0

1.9

100.58

97.20

pmol/l

0.12

150

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.16

1.31

3.2

2.8

1.11

1.25

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

101

1.84

1.31

2.3

1.9

—

(4094501) Cardiovascular stress test using bicycle ergometer

2.87

1.30

1.4

1.2

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.87

1.30

1.4

2.9

94.20

91.28

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

644

1.73

1.30

9.1

7.7

78.48

79.90

u/l

0.10

601

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

2.00

1.24

1.2

1.4

—

(3024928) Oxygen saturation in Venous blood

2.72

1.23

1.2

3.3

—

(3000492) Spirometry study

2.05

1.23

1.3

1.6

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.40

1.20

2.3

2.6

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.58

1.16

1.4

1.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.04

1.12

1.7

1.4

—

(1761868) Lipid panel - Serum or Plasma

282

1.52

1.11

3.9

3.0

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.46

1.10

1.0

1.2

—

(40768804) Tissue Pathology biopsy report

339

1.50

1.09

2.5

2.1

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

795

2.09

1.09

5.8

4.6

4.67

4.70

mmol/l

0.09

735

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.80

1.01

2.8

2.0

0.21

g/l

0.01

(3014007) Fractional oxyhemoglobin in Arterial blood

1.88

1.00

7.2

6.8

95.26

94.87

—

(40768793) Breast Pathology biopsy report

0.00

0.99

0.0

1.3

—

(36660697) Celiac disease serology panel - Serum

1.82

0.98

1.2

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.77

0.97

2.3

1.8

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

618

1.54

0.97

5.1

4.2

14.49

14.79

pmol/l

0.44

550

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.22

0.93

1.3

1.8

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

791

1.87

0.92

5.8

4.6

1.53

1.54

mmol/l

0.01

726

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

767

1.76

0.89

5.0

4.1

1.23

1.25

mmol/l

0.11

700

(3049717) Cytology report of Urine Cyto stain

2.07

0.88

1.7

3.0

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.00

0.86

1.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.81

0.85

1.8

1.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

115

1.59

0.84

2.1

1.8

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.73

0.81

2.1

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.66

0.80

2.3

1.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

385

1.39

0.79

3.3

2.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.24

0.77

1.2

2.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.74

0.77

5.1

2.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

127

1.52

0.75

1.8

1.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

813

1.77

0.74

6.5

5.2

2.75

mmol/l

0.01

748

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.76

0.72

6.6

7.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.72

0.70

1.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

238

1.38

0.69

1.6

1.18

1.25

mmol/l

0.16

204

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

239

1.38

0.67

1.8

2.0

116.12

143.68

u/l

0.55

223

(3035350) Ketones [Presence] in Urine by Test strip

423

1.33

0.65

4.6

3.7

0.00

estimate

—

(3026493) Urate [Moles/volume] in Serum or Plasma

213

1.38

0.64

5.1

3.0

397.86

8659.85

umol/l

1.52

178

(3037467) Urinalysis macro (dipstick) panel - Urine

556

1.35

0.63

5.5

3.9

—

(3025941) Bacteria identified in Stool by Culture

1.62

0.62

1.5

1.2

—

(3019060) Gas panel - Arterial blood

1.59

0.61

3.3

4.2

—

(3042936) Bacteria identified in Isolate by Culture

124

1.45

0.61

4.1

1.9

—

(3022145) Colonoscopy Study observation

107

1.48

0.60

1.3

1.4

—

(4035726) Immunohistochemistry procedure

0.55

0.59

1.8

1.3

—

(3022217) INR in Platelet poor plasma by Coagulation assay

388

1.31

0.59

24.6

13.5

1.18

1.28

inr

0.33

123

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

179

1.38

0.59

3.2

2.1

—

(40758558) Short blood count panel - Blood

216

1.35

0.59

5.6

8.0

—

(3023368) Bacteria identified in Blood by Culture

207

1.36

0.58

8.8

4.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

321

1.31

0.57

4.9

3.6

26.17

35.78

ng/l

0.56

221

(3044640) Blood type and Crossmatch panel - Blood

246

1.32

0.55

3.6

2.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

775

1.49

0.54

23.2

13.2

73.06

79.50

ml/min/173m2

1.65

620

(3002256) Pathology report gross observation

102

1.44

0.51

1.4

1.2

—

(3044889) 12 lead EKG panel

577

1.28

0.48

4.4

4.0

—

(3029937) Albumin [Presence] in Urine by Test strip

248

0.75

0.47

6.3

4.0

0.00

estimate

—

(3021601) Nitrite [Presence] in Urine by Test strip

427

1.26

0.46

6.5

4.8

0.00

estimate

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

792

1.45

0.44

5.7

4.7

6.10

5.94

mmol/l

0.53

727

(3045414) Leukocytes [Presence] in Urine

1.59

0.43

1.4

1.9

—

(3041096) Erythrocytes [Presence] in Urine by Automated

236

1.27

0.42

4.1

3.3

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.50

0.41

2.6

1.6

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

237

1.26

0.40

4.7

3.1

2894.91

1018.96

ng/l

0.65

204

(3007164) IgA [Mass/volume] in Serum or Plasma

181

1.28

0.39

2.6

1.4

2.25

2.82

g/l

0.57

111

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.49

0.37

1.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.46

0.36

1.2

2.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.46

0.36

2.5

2.2

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

744

1.30

0.35

6.4

4.9

1.76

1.92

mu/l

0.70

673

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

157

1.26

0.33

1.4

—

(3003694) ABO and Rh group [Type] in Blood

207

1.21

0.29

1.3

1.4

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

198

1.21

0.28

1.3

1.2

0.83

0.87

u/ml

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

126

0.77

0.26

3.0

3.4

1.19

0.71

ug/l

—

(40761535) Cells panel - Urine sediment

1.20

0.25

5.3

3.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.32

0.25

1.6

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

794

1.28

0.25

25.9

13.9

24.39

22.28

mg/l

0.25

619

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.28

0.24

2.6

1.6

—

(3000494) Fungus identified in Specimen by Culture

1.26

0.22

1.2

1.4

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

1.3

—

91.05

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.0

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

0.00

0.21

0.0

2.0

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

0.00

0.21

0.0

2.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.8

—

16.43

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.21

0.0

1.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.3

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.2

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.20

0.0

1.4

—

1.41

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.9

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.20

0.0

1.6

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.9

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.20

0.0

1.1

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

766

1.21

0.20

9.1

5.6

41.44

39.92

mmol/mol

0.65

708

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.16

0.19

2.0

3.0

505.67

192.02

ng/l

—

(4200892) Spirometry reversibility

0.72

0.17

1.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.14

0.16

3.2

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

113

1.17

0.14

9.2

7.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.20

0.13

4.0

3.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

146

1.12

0.09

1.4

1.2

15.96

35.25

iu/ml

—

(21494755) Public health laboratory ask at order entry panel

1.08

0.09

1.3

—

(3022621) pH of Urine by Test strip

0.82

0.08

1.4

2.2

—

(3019225) pH of Specimen

1.10

0.08

3.6

4.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

344

1.08

0.08

5.1

3.8

—

(40761536) Microorganisms panel - Urine sediment

1.07

0.07

3.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

476

1.06

0.06

3.7

2.6

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

527

1.06

0.06

2.8

34.58

45.44

u/l

1.42

490

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

1.11

0.04

3.1

5.4

234.60

252.02

u/l

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

143

1.06

0.01

1.5

1.3

41.23

6.84

u/ml

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

198

1.01

0.00

5.3

3.7

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

169

1.01

0.00

4.6

4.7

23.99

20.91

0.63

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.4

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

0.92

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

11.60

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.2

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.2

—

168.34

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

1.64

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

2.6

—

156.60

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.2

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.8

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

5.64

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

2.2

—

15.93

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.5

—

70.33

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.4

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

862

1.14

-0.00

14.1

10.8

22.70

24.38

u/l

1.13

829

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.7

—

0.62

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.89

-0.00

1.4

1.2

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.5

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

-0.00

0.0

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

5.2

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.2

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.6

—

4.14

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

295.00

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

-0.00

0.0

1.4

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

-0.00

0.0

1.0

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

-0.00

0.0

2.2

—

14.50

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

3.3

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

-0.00

0.0

1.7

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(3045142) Bone marrow Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

-0.00

0.0

1.7

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

-0.00

0.0

3.1

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

-0.00

0.0

1.3

—

(40761511) CBC panel - Blood by Automated count

842

1.11

-0.00

21.5

12.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_VITRPROLAPSE and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_VITRPROLAPSE	1.037 [0.8, 1.35]	0.788
Birth year	0.997 [0.99, 1.01]	0.478

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 299 females with H7_VITRPROLAPSE died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_VITRPROLAPSE.

N-year risk	Females	Males
1	0.133%	No data
5	0.737%	No data
10	1.708%	No data
15	3.248%	No data
20	5.587%	No data

Relationships between endpoints

↥

Index endpoint: H7_VITRPROLAPSE – Vitreous prolapse

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Vitreous prolapse

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints