eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
88 |
4. Check minimum number of eventsNone |
88 |
5. Include endpointsNone |
88 |
6. Filter based on genotype QC (FinnGen only) |
88 |
Control definitions (FinnGen only)
- Control exclude
- H7_VITREOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H43
- Name in latin
- Prolapsus corporis vitrei
Similar endpoints
↥List of similar endpoints to
Vitreous prolapse
based on the number of shared cases.
Similar with more cases:
- Disorders of vitreous body
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 559 | 343 | 212 |
| Only index persons | 534 | 334 | 200 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 63.03 | 63.47 | 62.46 |
| Only index persons | 62.75 | 63.45 | 61.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 88 | 59 | 29 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 59.65 | 57.86 | 63.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 78
- Matched controls
- 779
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H43.0
ICD-10 Finland
Vitreous prolapse
+∞
112.2
78
*
H43.8
ICD-10 Finland
Other disorders of vitreous body
120.3
24.3
25
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
+∞
19.6
18
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
5.1
9.6
37
117
S01ED01
ATC
timolol; ophthalmic
15.2
8.8
14
11
H3603, E103
ICD-10 Finland
NA
100.5
8.6
9
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
25.2
8.3
11
5
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
25.2
8.3
11
5
CJB10
NOMESCO Finland
Laser discission of secondary cataract
8.0
7.6
17
26
CKC10
NOMESCO Finland
Local photocoagulation of retina
88.1
7.6
8
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
88.1
7.6
8
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.9
7.3
21
46
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.7
6.9
41
181
H26.4
ICD-10 Finland
After-cataract
6.5
6.6
17
32
H33.3
ICD-10 Finland
Retinal breaks without detachment
16.7
6.1
9
6
Mortality – FinRegistry
↥Association
Association between endpoint H7_VITRPROLAPSE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VITRPROLAPSE | 1.037 [0.8, 1.35] | 0.788 |
| Birth year | 0.997 [0.99, 1.01] | 0.478 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 299 females with H7_VITRPROLAPSE died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have H7_VITRPROLAPSE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.133% | No data |
| 5 | 0.737% | No data |
| 10 | 1.708% | No data |
| 15 | 3.248% | No data |
| 20 | 5.587% | No data |
Relationships between endpoints
↥Index endpoint: H7_VITRPROLAPSE – Vitreous prolapse
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data