cholesteatoma of external ear: A cholesteatoma which involves invasion of the squamous tissue into a localized area of bony erosion of the ear canal. It may develop spontaneously or as a consequence of infection, trauma or surgery.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
273 |
4. Check minimum number of eventsNone |
273 |
5. Include endpointsNone |
273 |
6. Filter based on genotype QC (FinnGen only) |
260 |
Control definitions (FinnGen only)
- Control exclude
- H8_EXTERNAL
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H60
- Name in latin
- Cholesteatoma meatus acustici externi
Similar endpoints
↥List of similar endpoints to
Cholesteatoma of external ear
based on the number of shared cases.
Similar with more cases:
- Otitis externa
- Diseases of external ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2037 | 1011 | 1016 |
| Only index persons | 1930 | 964 | 966 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 64.36 | 65.08 | 63.74 |
| Only index persons | 63.84 | 64.05 | 63.64 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 260 | 110 | 150 |
| Unadjusted period prevalence (%) | 0.06 | 0.04 | 0.07 |
| Median age at first event (years) | 66.03 | 64.00 | 67.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 273
- Matched controls
- 2730
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H60.4
ICD-10 Finland
Cholesteatoma of external ear
+∞
307.7
273
*
UDC00
NOMESCO Finland
Ear microscopy
15.7
105.6
114
119
H71
ICD-10 Finland
Cholesteatoma of middle ear
123.7
70.0
73
8
H60.9
ICD-10 Finland
Otitis externa, unspecified
13.4
66.4
71
70
H60.8
ICD-10 Finland
Other otitis externa
22.6
51.2
39
20
DFF00
NOMESCO Finland
Pure tone audiometry
7.3
47.0
86
162
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
17.3
45.1
39
26
DC1AD
NOMESCO Finland
Temporalbone CT
84.8
44.7
49
7
H66.0
ICD-10 Finland
Acute suppurative otitis media
9.6
43.4
57
73
H61.2
ICD-10 Finland
Impacted cerumen
9.2
39.2
53
70
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
151.0
37.8
39
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
5.0
31.6
88
237
H66.9
ICD-10 Finland
Otitis media, unspecified
8.8
29.7
40
52
H61.8
ICD-10 Finland
Other specified disorders of external ear
116.1
29.3
31
*
TDA90
NOMESCO Finland
Removal wax from ear
34.3
28.0
36
12
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
10.0
27.4
33
37
H60.3
ICD-10 Finland
Other infective otitis externa
24.9
25.1
35
16
DBB00
NOMESCO Finland
Excision of lesion of external auditory canal
+∞
20.0
19
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
16.9
18.4
29
19
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
22.8
17.7
25
12
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
45.3
17.5
21
5
H01
ICPC
Ear pain/earache
4.2
16.4
49
135
DCD00
NOMESCO Finland
Myringoplasty
23.8
15.8
22
10
H04
ICPC
Ear discharge
6.8
14.8
24
38
H13
ICPC
Plugged feeling ear
3.0
14.7
84
350
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
14.7
14
*
DFF15
NOMESCO Finland
Speech audiometry
4.8
14.5
35
81
H65.2
ICD-10 Finland
Chronic serous otitis media
29.0
14.5
19
7
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.0
14.2
78
318
H92.0
ICD-10 Finland
Otalgia
5.8
14.0
27
51
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.9
13.6
82
351
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
13.1
13.4
23
19
H70
ICPC
Otitis externa
14.0
13.2
22
17
R5120
NOMESCO Finland
Preparation of an aid
6.0
13.1
24
43
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
73.4
12.7
14
*
DBD10
NOMESCO Finland
Reconstruction of external auditory canal
+∞
12.6
12
*
ZXA05
NOMESCO Finland
Left side
2.7
12.6
96
462
H60
ICD-10 Finland
Otitis externa
5.0
11.9
27
59
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
5.1
11.9
26
55
H70.1
ICD-10 Finland
Chronic mastoiditis
125.1
11.5
12
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
4.0
10.8
32
87
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
3.0
10.4
54
210
S02CA02
ATC
flumetasone and antiinfectives; otic
4.0
9.9
29
78
H81
ICPC
Excessive ear wax
2.6
9.8
68
308
DCD10
NOMESCO Finland
Tympanoplasty
57.1
9.7
11
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
18.3
9.5
14
8
DBB02
NOMESCO Finland
Excision of a neoplasm from external auditory canal
+∞
9.4
9
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.7
9.4
31
91
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
51.7
8.7
10
*
SPAT1260
SPAT
Consultation of another employee
2.5
8.5
61
279
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
92.8
8.5
9
*
H61.9
ICD-10 Finland
Disorder of external ear, unspecified
92.8
8.5
9
*
DAX08
NOMESCO Finland
Fitting of hearing aid
3.5
8.4
30
93
Z97.4
ICD-10 Finland
Presence of external hearing-aid
3.6
8.3
29
88
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
12.2
8.2
14
12
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
17.8
8.1
12
7
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
7.3
7.9
18
26
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
10.5
7.6
14
14
H74.1
ICD-10 Finland
Adhesive middle ear disease
82.2
7.5
8
*
WX704
NOMESCO Finland
Intubation
3.3
7.4
29
95
S18
ICPC
Laceration/cut
2.0
7.2
140
943
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
4.4
7.1
18
43
H29
ICPC
Ear symptom/complaint other
2.7
7.1
40
162
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
7.0
83
468
R02
ICPC
Shortness of breath/dyspnoea
2.6
6.9
44
189
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
41.1
6.8
8
*
WX110
NOMESCO Finland
Infiltration anesthesia
2.0
6.8
191
1453
J01DB01
ATC
cefalexin; oral
2.3
6.4
228
1872
J01CA04
ATC
amoxicillin; systemic
2.2
6.4
221
1793
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
2.9
6.3
31
116
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
18.5
6.3
9
5
J01MA02
ATC
ciprofloxacin; systemic
1.9
6.3
117
768
ELB50
NOMESCO Finland
Total parotidectomy
+∞
6.3
6
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
3.8
6.2
19
53
D23.2
ICD-10 Finland
Benign neoplasm: Skin of ear and external auricular canal
10.4
6.1
11
11
SPAT1263
SPAT
Sampling
1.9
6.1
121
810
H91.9
ICD-10 Finland
Hearing loss, unspecified
3.1
6.0
25
85
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
210
1716
1.97
5.28
9.2
8.0
81.38
80.27
u/l
0.11
198
1607
82
510
1.87
5.00
1.9
1.8
1.08
1.45
mg/l
1.01
66
407
103
696
1.77
4.75
2.2
2.1
202.16
219.22
u/l
0.10
95
654
139
1023
1.73
4.73
3.2
2.6
—
—
—
0
0
247
2180
2.40
4.52
25.5
15.6
25.47
24.87
mg/l
0.10
210
1749
52
287
2.00
4.48
5.2
7.0
2.06
1.04
mmol/l
1.02
45
228
149
1130
1.70
4.45
25.5
14.6
1.27
1.29
inr
0.08
51
326
164
1287
1.69
4.22
10.2
9.7
4.36
4.15
e9/l
0.59
151
1139
41
212
2.10
4.20
2.2
2.7
6.73
7.62
ug/l
0.10
36
189
141
1093
1.60
3.59
5.0
3.8
0.00
0.00
estimate
0.50
29
227
152
1202
1.60
3.54
3.1
2.7
—
—
—
0
0
192
1613
1.64
3.42
5.8
4.2
14.69
12.81
mm/h
0.91
181
1483
254
2324
2.34
3.31
26.9
18.6
88.85
80.78
umol/l
0.75
254
2324
143
1128
1.56
3.27
9.0
6.8
1.19
1.21
mmol/l
1.72
124
952
101
741
1.58
3.15
3.5
3.5
2.32
2.35
mmol/l
0.88
89
658
59
380
1.70
3.08
2.3
1.9
—
—
—
0
0
45
268
1.81
3.07
9.4
8.7
—
—
—
0
0
138
1091
1.54
3.06
6.4
5.2
0.00
0.00
estimate
-0.00
29
210
5
5
10.15
2.99
1.0
1.2
81.20
105.40
%
—
5
5
16
64
2.59
2.93
1.8
1.5
—
—
—
0
0
116
891
1.52
2.89
2.4
2.3
81.66
76.72
nmol/l
1.12
105
784
113
864
1.53
2.87
5.5
4.0
—
—
—
0
0
166
1377
1.52
2.87
5.7
4.7
6.84
6.80
mmol/l
0.09
154
1285
236
2131
1.79
2.80
4.8
4.8
6.05
6.06
mmol/l
0.06
216
1964
138
1107
1.50
2.76
5.1
3.8
0.00
0.00
estimate
-0.00
26
196
69
478
1.59
2.69
5.8
4.2
1.02
1.02
kg/l
0.12
11
69
250
2305
2.00
2.67
13.9
11.0
24.29
26.27
u/l
1.15
245
2238
120
949
1.47
2.51
4.7
4.1
28.79
45.15
ng/l
1.51
94
698
221
1978
1.62
2.50
5.2
4.5
2.23
1.99
mu/l
1.61
201
1804
15
65
2.38
2.36
1.1
1.6
—
—
—
0
0
64
450
1.55
2.33
4.9
3.8
434.87
240.31
ng/l
0.25
52
376
129
1046
1.44
2.32
8.1
5.9
1.19
1.21
mmol/l
2.12
124
945
256
2399
2.08
2.30
34.9
23.0
39.73
40.18
%
0.59
237
2244
6
13
4.69
2.28
1.0
2.1
—
—
—
0
0
256
2400
2.07
2.28
34.8
22.9
4.40
4.48
e12/l
1.40
256
2335
256
2401
2.06
2.26
34.9
23.0
132.45
135.49
g/l
2.46
256
2370
5
9
5.63
2.22
1.6
2.1
14.48
13.56
%
—
5
9
41
263
1.66
2.17
2.3
1.9
—
—
—
0
0
41
263
1.66
2.17
2.5
1.8
—
—
—
0
0
114
916
1.42
2.10
2.3
2.1
87.79
94.88
pmol/l
0.68
69
483
80
602
1.47
2.10
6.2
4.0
0.00
0.00
estimate
-0.00
27
201
239
2206
1.67
2.09
5.2
5.2
2.54
2.67
mmol/l
1.53
223
2038
27
155
1.82
2.09
2.0
1.3
—
—
—
0
0
9
31
2.97
2.09
1.1
1.6
—
—
—
0
0
9
31
2.97
2.09
1.1
1.6
—
—
—
0
0
5
10
5.07
2.08
1.4
1.8
79.00
82.40
umol/l
—
5
10
255
2398
1.96
2.07
34.9
22.9
245.07
242.44
e9/l
0.27
255
2340
130
1076
1.40
2.00
8.7
5.8
26.79
26.99
%
0.05
125
1019
181
1586
1.42
1.98
4.6
3.7
14.63
14.88
pmol/l
0.67
164
1424
28
166
1.77
1.96
1.5
1.7
—
—
—
0
0
77
582
1.45
1.96
2.3
2.1
2.67
3.16
mg/l
1.16
66
508
11
45
2.51
1.95
1.2
1.6
—
—
—
0
0
128
1062
1.39
1.91
8.5
5.7
58.48
57.82
%
0.22
123
1011
225
2062
1.52
1.87
19.3
14.8
77.84
77.90
ml/min/173m2
0.01
195
1715
54
384
1.51
1.86
1.9
2.1
29.02
29.80
s
0.80
49
374
12
53
2.32
1.83
1.2
1.5
—
—
—
0
0
14
67
2.15
1.79
1.1
1.6
—
—
—
0
0
6
18
3.38
1.75
4.5
4.1
12.73
105.54
u/ml
—
6
18
6
18
3.38
1.75
1.2
1.1
—
—
—
0
0
233
2161
1.53
1.72
5.0
4.7
4.48
4.54
mmol/l
0.46
217
2007
99
803
1.37
1.65
4.7
4.6
22.12
21.03
%
0.30
53
399
231
2147
1.49
1.60
4.9
4.6
1.44
1.44
mmol/l
0.05
213
1985
17
93
1.88
1.55
2.4
3.0
—
—
—
0
0
19
108
1.82
1.55
1.6
1.2
944.83
201.00
u/ml
0.77
19
96
94
763
1.35
1.55
3.2
3.4
1247.80
1520.59
ng/l
0.37
87
657
103
852
1.34
1.49
4.3
3.2
—
—
—
0
0
5
16
3.16
1.44
5.8
1.9
—
—
—
0
0
6
23
2.64
1.37
1.2
1.3
—
—
—
0
0
59
456
1.37
1.31
1.7
1.8
1199.51
1238.97
nmol/l
0.12
44
346
12
62
1.98
1.30
1.4
1.7
—
—
—
0
0
10
48
2.12
1.29
1.1
1.7
—
—
—
0
0
10
48
2.12
1.29
1.1
1.7
—
—
—
0
0
81
663
1.32
1.23
3.6
3.0
0.30
0.55
e6/l
0.80
64
503
67
534
1.34
1.22
2.6
2.4
—
—
—
0
0
158
1413
1.28
1.21
3.7
3.3
57.39
52.28
u/l
0.35
144
1327
25
166
1.56
1.20
3.1
3.5
1.36
1.82
mmol/l
0.38
19
124
33
235
1.46
1.15
3.8
3.6
—
—
—
0
0
5
21
2.41
1.09
1.0
1.1
—
—
u/ml
—
0
0
72
590
1.30
1.08
3.0
2.9
356.98
6486.93
umol/l
2.38
61
515
7
34
2.09
1.03
1.3
1.3
—
—
—
0
0
219
2063
1.31
1.00
7.0
6.2
41.22
40.58
mmol/mol
0.40
201
1928
9
50
1.83
0.97
1.0
1.6
—
—
—
0
0
114
1004
1.23
0.92
5.0
5.2
1.84
2.78
ug/l
1.28
105
911
57
463
1.29
0.91
1.3
1.3
0.84
1.44
u/ml
—
10
140
6
30
2.02
0.87
1.0
1.9
—
—
—
0
0
6
30
2.02
0.87
1.0
1.9
—
—
—
0
0
6
30
2.02
0.87
1.0
1.9
—
—
—
0
0
8
45
1.80
0.85
1.3
1.5
—
—
—
0
0
15
97
1.58
0.83
4.0
2.0
—
—
—
0
0
68
573
1.25
0.82
3.5
3.0
0.69
0.74
ug/l
0.21
52
383
39
306
1.32
0.81
1.3
1.3
1.46
13.31
u/ml
1.62
16
111
104
918
1.21
0.81
3.3
2.7
127.52
146.13
ug/l
0.37
93
839
68
577
1.24
0.77
1.6
1.6
19.68
20.83
nmol/l
0.21
60
495
7
38
1.86
0.74
1.0
1.7
—
—
—
0
0
13
84
1.57
0.73
1.5
1.8
—
—
—
0
0
5
25
2.02
0.73
1.4
2.2
—
—
—
0
0
34
266
1.32
0.73
3.8
4.5
6.94
55.57
ug/l
0.95
28
228
7
40
1.77
0.72
1.0
1.4
—
—
—
0
0
30
231
1.34
0.71
2.2
1.7
1.65
1.58
%
0.22
25
198
14
93
1.53
0.71
1.6
2.0
—
—
—
0
0
5
29
1.74
0.64
1.0
1.3
—
—
—
0
0
218
2087
1.22
0.63
4.5
4.2
1.32
1.28
mmol/l
0.34
199
1921
5
30
1.68
0.61
1.0
2.0
—
—
—
0
0
17
122
1.42
0.61
1.4
1.7
—
—
—
0
0
12
174
0.68
0.61
1.4
1.8
—
—
—
0
0
24
184
1.33
0.60
3.1
3.0
80.00
62.45
ml/min/173m2
—
9
83
8
52
1.55
0.60
2.1
1.3
—
—
—
0
0
6
35
1.73
0.58
1.0
1.1
—
—
—
0
0
82
735
1.17
0.52
3.6
3.9
10.60
9.34
mg/mmol
0.09
55
477
66
582
1.18
0.51
1.8
1.7
2.10
1.33
mmol/l
0.72
54
483
10
67
1.51
0.50
1.2
1.6
—
0.06
—
0
15
18
137
1.34
0.48
1.4
1.8
—
—
—
0
0
58
509
1.18
0.48
1.7
1.9
302222663.09
428.38
pmol/l
0.78
45
424
29
237
1.25
0.48
7.4
3.6
6.09
5.70
kpa
2.15
29
229
7
49
1.44
0.46
1.6
1.1
—
—
—
0
0
7
50
1.41
0.45
1.1
1.5
—
—
—
0
0
5
32
1.57
0.42
1.0
2.0
—
—
—
0
0
5
33
1.52
0.41
2.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
25
205
1.24
0.41
5.4
2.9
4.26
4.51
kpa
0.43
25
196
8
61
1.32
0.40
1.6
1.9
—
—
—
0
0
38
328
1.18
0.39
1.4
1.2
14.33
40.72
iu/ml
3.13
15
106
8
112
0.71
0.38
4.1
3.7
82.75
1871.80
u/ml
—
8
92
6
41
1.47
0.36
1.2
1.6
—
—
—
0
0
10
73
1.38
0.35
1.7
1.2
—
—
—
0
0
38
334
1.16
0.32
4.0
2.5
20.15
22.03
%
0.31
27
293
7
54
1.30
0.30
1.7
1.5
—
—
—
0
0
27
232
1.18
0.30
1.9
1.4
—
—
—
0
0
26
223
1.18
0.29
5.5
6.6
1.81
1.36
mmol/l
0.87
26
218
8
65
1.24
0.27
1.6
1.9
—
—
—
0
0
8
66
1.22
0.27
1.5
1.3
—
—
—
0
0
15
124
1.22
0.24
4.1
2.6
0.67
0.66
%
0.06
15
124
5
38
1.32
0.23
1.6
1.0
—
—
—
0
0
5
38
1.32
0.23
2.8
3.9
—
4554.50
—
0
6
10
79
1.28
0.22
3.2
3.2
—
1.43
—
0
10
5
40
1.25
0.22
2.4
2.9
56.00
57.75
%
—
5
40
5
40
1.25
0.22
1.2
1.4
74.00
90.56
pmol/l
—
5
40
5
42
1.19
0.21
1.2
1.3
3.24
3.86
mmol/l
—
5
37
0
11
0.00
0.21
0.0
1.1
—
1.30
—
0
5
0
10
0.00
0.21
0.0
1.8
—
65.73
—
0
10
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
10
80
1.26
0.21
3.3
3.3
46.28
149.11
mg/l
—
10
62
10
80
1.26
0.21
3.3
3.3
73.13
32.41
mg/l
—
10
63
6
48
1.26
0.20
1.7
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
31
280
1.12
0.19
4.5
4.7
33.15
31.26
%
0.39
20
200
34
309
1.11
0.19
1.8
1.5
—
—
—
0
0
43
398
1.10
0.18
3.6
2.8
0.73
1.06
e6/l
0.51
23
229
15
129
1.17
0.17
4.1
2.7
1.23
1.25
%
0.02
15
129
5
48
1.04
0.09
1.0
1.2
—
—
—
0
0
36
372
0.96
0.04
4.2
3.0
1.18
1.88
e6/l
0.60
17
208
15
143
1.05
0.01
2.3
1.7
—
—
—
0
0
13
128
1.02
0.00
1.2
1.3
—
49.77
—
0
14
11
111
0.99
0.00
1.3
1.3
—
—
—
0
0
5
51
0.98
-0.00
1.2
1.3
—
—
—
0
0
9
94
0.96
-0.00
1.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
15.20
—
0
5
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
7
0.00
-0.00
0.0
1.0
—
146.14
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
8.77
—
0
7
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
67
0.89
-0.00
1.2
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
-0.00
0.0
1.0
—
118.40
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
5
51
0.98
-0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.1
—
—
—
0
0
6
67
0.89
-0.00
1.2
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
8.28
—
0
8
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_EXT_CHOL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXT_CHOL | 1.283 [1.02, 1.62] | 0.035 |
| Birth year | 0.998 [0.99, 1.01] | 0.613 |
During the follow-up period (1.1.1998 — 31.12.2019), 222 out of 870 females with H8_EXT_CHOL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXT_CHOL | 1.268 [1.01, 1.6] | 0.043 |
| Birth year | 0.99 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 225 out of 883 males with H8_EXT_CHOL died.
Mortality risk
Mortality risk for people of age
years, who have H8_EXT_CHOL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.122% | 0.26% |
| 5 | 0.774% | 1.499% |
| 10 | 2.0% | 3.783% |
| 15 | 3.865% | 7.259% |
| 20 | 6.95% | 12.422% |
Relationships between endpoints
↥Index endpoint: H8_EXT_CHOL – Cholesteatoma of external ear
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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