cholesteatoma of external ear: A cholesteatoma which involves invasion of the squamous tissue into a localized area of bony erosion of the ear canal. It may develop spontaneously or as a consequence of infection, trauma or surgery.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
246 |
4. Check minimum number of eventsNone |
246 |
5. Include endpointsNone |
246 |
6. Filter based on genotype QC (FinnGen only) |
246 |
Control definitions (FinnGen only)
- Control exclude
- H8_EXTERNAL
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H60
- Name in latin
- Cholesteatoma meatus acustici externi
Similar endpoints
↥List of similar endpoints to
Cholesteatoma of external ear
based on the number of shared cases.
Similar with more cases:
- Otitis externa
- Diseases of external ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2037 | 1011 | 1016 |
| Only index persons | 1930 | 964 | 966 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 64.36 | 65.08 | 63.74 |
| Only index persons | 63.84 | 64.05 | 63.64 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 246 | 106 | 140 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | 65.10 | 62.72 | 66.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 222
- Matched controls
- 2220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H60.4
ICD-10 Finland
Cholesteatoma of external ear
+∞
321.5
222
*
UDC00
NOMESCO Finland
Ear microscopy
24.5
61.0
90
60
H71
ICD-10 Finland
Cholesteatoma of middle ear
91.1
60.2
65
10
DC1AD
NOMESCO Finland
Temporalbone CT
465.5
40.5
39
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
21.9
36.4
54
32
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
404.0
35.0
34
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
39.7
25.0
31
9
Z01.1
ICD-10 Finland
Examination of ears and hearing
6.0
23.5
74
171
H60.3
ICD-10 Finland
Other infective otitis externa
36.8
23.1
29
9
DFF00
NOMESCO Finland
Pure tone audiometry
7.0
22.7
61
114
H60.8
ICD-10 Finland
Other otitis externa
35.3
22.1
28
9
H66.0
ICD-10 Finland
Acute suppurative otitis media
11.0
21.5
42
46
TDA90
NOMESCO Finland
Removal wax from ear
33.9
21.1
27
9
H61.8
ICD-10 Finland
Other specified disorders of external ear
85.3
21.1
23
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
46.7
20.9
25
6
H61.2
ICD-10 Finland
Impacted cerumen
10.8
18.5
36
39
H66.9
ICD-10 Finland
Otitis media, unspecified
10.1
15.6
31
35
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
11.3
15.0
28
28
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
57.2
14.0
16
*
DBB00
NOMESCO Finland
Excision of lesion of external auditory canal
80.2
13.8
15
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
13.7
13
*
DCD00
NOMESCO Finland
Myringoplasty
26.1
12.7
17
7
DFF15
NOMESCO Finland
Speech audiometry
7.0
11.4
28
45
H65.2
ICD-10 Finland
Chronic serous otitis media
26.6
11.3
15
6
H70
ICPC
Otitis externa
12.9
11.1
19
16
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
11.4
11.0
20
19
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
19.0
10.9
16
9
H70.1
ICD-10 Finland
Chronic mastoiditis
115.2
10.5
11
*
H13
ICPC
Plugged feeling ear
3.2
10.5
64
252
H01
ICPC
Ear pain/earache
4.6
10.2
36
90
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.1
9.8
63
254
R5120
NOMESCO Finland
Preparation of an aid
8.0
9.2
20
27
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
38.4
9.1
11
*
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
+∞
8.4
8
*
H04
ICPC
Ear discharge
7.3
8.3
19
28
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
18.0
8.2
12
7
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
6.6
8.1
20
33
S18
ICPC
Laceration/cut
2.3
8.0
110
667
H92.0
ICD-10 Finland
Otalgia
6.4
7.9
20
34
H60
ICD-10 Finland
Otitis externa
7.9
7.8
17
23
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
46.6
7.8
9
*
DCD10
NOMESCO Finland
Tympanoplasty
46.6
7.8
9
*
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
46.6
7.8
9
*
J01CA04
ATC
amoxicillin; systemic
2.6
7.7
181
1406
D23.2
ICD-10 Finland
Benign neoplasm: Skin of ear and external auricular canal
26.0
7.6
10
*
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
8.1
7.5
16
21
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
8.8
7.4
15
18
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
8.8
7.4
15
18
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
5.2
7.4
22
46
ZXA05
NOMESCO Finland
Left side
2.4
7.3
77
407
DBD10
NOMESCO Finland
Reconstruction of external auditory canal
+∞
7.3
7
*
DBB02
NOMESCO Finland
Excision of a neoplasm from external auditory canal
+∞
7.3
7
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
16.4
7.3
11
7
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
20.8
7.2
10
5
WX110
NOMESCO Finland
Local anesthesy
2.2
7.2
150
1078
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.5
7.1
64
309
H81
ICPC
Excessive ear wax
2.7
6.7
50
218
H68.1
ICD-10 Finland
Obstruction of Eustachian tube
18.7
6.3
9
5
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
6.3
6
*
J01DB01
ATC
cefalexin; oral
2.3
6.1
183
1482
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.7
6.1
44
187
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
48
257
2.08
4.54
5.4
6.6
2.0
1.1
mmol/l
0.76
40
198
72
451
1.84
4.30
1.5
1.8
1.1
1.5
mg/l
0.70
59
361
222
1959
2.37
4.07
25.4
15.4
26.9
24.7
mg/l
0.43
190
1568
38
194
2.13
4.05
2.2
2.6
3.8
6.3
ug/l
1.29
33
173
125
931
1.70
4.03
5.6
4.1
—
—
—
0
0
92
634
1.72
3.93
2.2
2.0
215.6
220.2
u/l
0.02
84
592
186
1554
1.81
3.86
8.7
7.8
79.0
80.1
u/l
0.11
174
1456
137
1070
1.63
3.50
3.1
2.6
—
—
—
0
0
127
975
1.63
3.47
5.1
3.7
0.0
0.0
estimate
0.00
26
189
43
244
1.92
3.44
9.3
8.6
—
—
—
0
0
144
1155
1.60
3.17
10.1
9.7
4.4
4.2
e9/l
0.66
132
1026
54
338
1.77
3.16
2.3
1.8
—
—
—
0
0
173
1458
1.63
3.03
5.8
4.1
14.7
12.8
mm/h
0.86
164
1335
124
979
1.54
2.80
6.4
5.1
0.0
0.0
estimate
0.00
26
191
228
2093
2.22
2.80
26.6
18.4
87.9
81.1
umol/l
0.55
228
2093
125
993
1.53
2.72
5.1
3.7
0.0
0.0
estimate
0.00
23
179
101
768
1.53
2.68
5.7
3.9
—
—
—
0
0
58
393
1.62
2.51
5.1
3.4
480.3
184.4
ng/l
0.38
47
326
148
1233
1.50
2.48
5.3
4.6
6.8
6.8
mmol/l
0.06
136
1148
126
1024
1.47
2.34
8.2
6.7
1.2
1.2
mmol/l
1.71
108
856
44
285
1.66
2.27
38.3
22.1
1.4
1.3
inr
0.23
12
33
199
1782
1.61
2.26
5.1
4.4
2.2
2.0
mu/l
1.33
180
1617
13
54
2.49
2.24
1.3
1.5
—
—
—
0
0
5
9
5.64
2.22
1.6
2.1
14.5
13.6
%
—
5
9
11
42
2.69
2.21
1.2
1.5
—
—
—
0
0
37
232
1.70
2.15
2.4
1.8
—
—
—
0
0
37
232
1.70
2.15
2.6
1.7
—
—
—
0
0
12
49
2.52
2.14
1.2
1.5
—
—
—
0
0
8
25
3.27
2.11
1.1
1.5
0.5
0.5
nmol/l
—
8
20
224
2079
1.87
2.10
13.3
10.9
24.2
26.1
u/l
1.00
219
2018
230
2153
2.05
2.10
34.4
22.9
132.5
135.4
g/l
2.09
230
2126
216
1989
1.70
2.02
5.1
5.2
2.5
2.7
mmol/l
1.28
201
1835
107
864
1.42
1.96
4.7
4.1
29.0
41.9
ng/l
1.06
82
635
210
1925
1.62
1.94
4.7
4.8
6.0
6.1
mmol/l
0.13
192
1773
24
138
1.82
1.87
2.0
1.3
—
—
—
0
0
85
663
1.43
1.87
3.4
3.5
2.3
2.3
mmol/l
0.50
75
583
25
146
1.79
1.86
1.5
1.7
—
—
—
0
0
5
12
4.23
1.83
1.0
1.5
—
—
—
0
0
13
61
2.19
1.75
1.1
1.6
—
—
—
0
0
5
13
3.90
1.72
5.8
1.1
—
—
—
0
0
5
13
3.90
1.72
1.2
1.1
—
—
—
0
0
71
544
1.43
1.70
6.4
4.0
0.0
0.0
estimate
0.00
25
183
94
757
1.39
1.70
4.3
3.1
—
—
—
0
0
113
940
1.37
1.67
7.2
5.8
1.2
1.2
mmol/l
2.35
108
843
210
1944
1.55
1.63
4.8
4.7
4.5
4.5
mmol/l
0.40
195
1803
101
834
1.36
1.53
2.3
2.0
89.6
95.0
pmol/l
0.43
62
439
67
519
1.40
1.50
2.3
2.0
2.7
3.2
mg/l
1.09
58
453
98
810
1.35
1.47
2.3
2.3
81.0
76.6
nmol/l
0.83
88
713
11
52
2.17
1.46
1.5
1.9
—
—
—
0
0
208
1933
1.49
1.46
4.7
4.6
1.4
1.4
mmol/l
0.21
192
1783
5
16
3.17
1.44
5.0
4.3
10.3
116.6
u/ml
—
5
16
201
1861
1.44
1.39
18.8
14.7
78.5
77.9
ml/min/173m2
0.16
175
1546
17
98
1.79
1.35
1.5
1.2
1043.9
187.8
u/ml
0.80
17
86
73
585
1.35
1.32
3.5
3.0
0.3
0.4
e6/l
0.30
56
447
15
84
1.84
1.30
2.2
3.0
—
—
—
0
0
12
62
1.98
1.30
1.1
1.6
—
—
—
0
0
160
1439
1.32
1.26
4.6
3.7
14.5
14.9
pmol/l
1.04
144
1286
87
721
1.32
1.25
4.9
4.6
21.4
21.0
%
0.10
47
356
66
526
1.35
1.23
3.0
3.0
354.1
7383.7
umol/l
2.39
55
452
5
20
2.53
1.15
1.0
1.1
—
—
u/ml
—
0
0
5
20
2.53
1.15
1.4
2.1
—
—
—
0
0
83
693
1.30
1.11
3.1
3.3
1351.2
1577.3
ng/l
0.25
76
591
7
33
2.15
1.06
1.0
1.6
—
—
—
0
0
5
22
2.30
1.04
1.2
1.3
—
—
—
0
0
17
107
1.63
1.02
1.4
1.6
—
—
—
0
0
14
85
1.69
0.96
1.6
2.0
—
—
—
0
0
13
78
1.70
0.93
1.5
1.8
—
—
—
0
0
197
1856
1.31
0.91
6.7
6.3
41.0
40.6
mmol/mol
0.22
179
1732
141
1278
1.24
0.91
3.4
3.1
56.0
51.7
u/l
0.26
127
1196
21
144
1.50
0.91
3.2
3.6
1.3
1.8
mmol/l
0.37
16
110
8
43
1.89
0.88
1.3
1.5
—
—
—
0
0
6
32
1.90
0.82
1.0
1.3
—
—
—
0
0
18
124
1.49
0.77
1.4
1.7
—
—
—
0
0
10
160
0.61
0.76
1.5
1.8
—
—
—
0
0
185
1743
1.25
0.76
24.8
16.1
39.2
39.8
%
0.36
103
1209
102
907
1.21
0.75
5.2
5.1
1.8
2.9
ug/l
1.25
93
823
58
486
1.25
0.75
2.6
2.3
—
—
—
0
0
31
239
1.34
0.74
3.9
4.6
3.7
61.8
ug/l
1.06
26
204
7
42
1.69
0.69
2.3
1.3
—
—
—
0
0
27
207
1.34
0.67
4.0
3.7
—
—
—
0
0
35
279
1.30
0.67
1.3
1.3
1.5
14.2
u/ml
1.61
15
103
5
28
1.80
0.66
1.0
1.1
—
—
—
0
0
5
28
1.80
0.66
1.0
1.9
—
—
—
0
0
5
28
1.80
0.66
1.0
1.9
—
—
—
0
0
5
28
1.80
0.66
1.0
1.9
—
—
—
0
0
10
62
1.64
0.66
1.2
1.7
—
0.1
—
0
15
50
419
1.24
0.65
1.7
1.8
1188.6
1217.7
nmol/l
0.08
36
317
8
53
1.53
0.59
1.7
1.9
—
—
—
0
0
26
203
1.31
0.58
6.4
3.7
1.4
2.0
mmol/l
0.30
18
154
60
522
1.20
0.55
1.6
1.6
19.3
21.0
nmol/l
0.30
53
446
6
38
1.59
0.54
1.2
1.6
—
—
—
0
0
9
64
1.42
0.52
1.8
1.2
—
—
—
0
0
91
827
1.16
0.50
3.0
2.6
125.4
149.1
ug/l
0.47
82
759
7
46
1.54
0.48
1.0
1.1
1.1
0.9
nmol/l
—
7
38
195
1877
1.19
0.48
4.3
4.2
1.3
1.3
mmol/l
0.56
178
1724
7
47
1.50
0.48
1.0
1.6
—
—
—
0
0
58
514
1.17
0.43
3.6
3.0
0.7
0.7
ug/l
0.17
44
343
21
167
1.28
0.43
3.1
3.0
80.0
61.0
ml/min/173m2
—
9
71
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
5
34
1.48
0.40
1.6
1.1
—
—
—
0
0
5
35
1.44
0.39
2.0
1.5
—
—
—
0
0
35
301
1.19
0.37
1.4
1.2
14.8
42.0
iu/ml
2.94
13
99
5
37
1.36
0.37
1.0
1.4
—
—
—
0
0
5
80
0.62
0.36
1.0
1.0
—
—
—
0
0
6
43
1.41
0.35
1.7
1.8
—
—
—
0
0
6
44
1.37
0.34
1.0
1.5
—
—
—
0
0
24
203
1.20
0.31
6.8
3.7
6.0
5.7
kpa
1.29
24
195
57
522
1.12
0.28
1.8
1.7
2.2
1.4
mmol/l
0.66
48
430
39
349
1.14
0.27
3.4
2.7
0.8
1.1
e6/l
0.43
21
205
12
95
1.28
0.27
4.5
3.2
23.4
24.1
mmol/l
—
7
87
51
466
1.12
0.26
1.7
1.9
340000425.3
433.3
pmol/l
0.78
40
386
9
74
1.22
0.25
3.4
3.2
—
1.5
—
0
8
9
75
1.21
0.25
3.6
3.3
49.4
159.8
mg/l
—
9
57
9
75
1.21
0.25
3.6
3.4
79.7
32.7
mg/l
—
9
58
20
173
1.17
0.21
4.7
3.0
4.0
4.4
kpa
0.72
20
164
0
11
0.00
0.21
0.0
1.3
—
1.0
—
0
6
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
6.3
—
0
7
0
12
0.00
0.21
0.0
3.6
—
98.3
—
0
12
11
89
1.25
0.21
4.7
2.0
5.9
7.5
g/l
—
5
68
11
89
1.25
0.21
4.7
2.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
24
214
1.13
0.18
1.8
1.4
—
—
—
0
0
7
61
1.15
0.17
1.7
1.8
—
—
—
0
0
7
63
1.11
0.17
1.6
1.3
—
—
—
0
0
33
302
1.11
0.17
2.9
2.4
21.2
21.9
%
0.09
22
265
43
400
1.09
0.16
1.2
1.2
0.9
1.2
u/ml
—
7
125
8
98
0.81
0.14
4.1
3.8
86.4
2116.7
u/ml
—
8
81
14
123
1.15
0.13
2.3
1.7
—
—
—
0
0
10
116
0.86
0.12
1.2
1.3
—
35.8
—
0
10
13
114
1.15
0.12
3.5
2.7
1.3
1.3
%
0.00
13
114
5
47
1.07
0.09
1.0
1.1
—
—
—
0
0
5
47
1.07
0.09
1.2
1.2
—
—
—
0
0
29
274
1.07
0.08
1.9
1.5
—
—
—
0
0
27
262
1.03
0.02
4.3
4.7
31.6
31.3
%
0.05
16
184
10
101
0.99
0.00
1.2
1.4
—
—
—
0
0
33
326
1.01
0.00
3.9
2.9
1.3
1.8
e6/l
0.42
16
187
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
1.0
—
118.4
—
0
5
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
65.5
—
0
8
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
9.2
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
0.00
0.0
1.0
—
145.8
—
0
6
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
5
59
0.84
0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
15.0
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
5
59
0.84
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_EXT_CHOL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXT_CHOL | 1.283 [1.02, 1.62] | 0.035 |
| Birth year | 0.998 [0.99, 1.01] | 0.613 |
During the follow-up period (1.1.1998 — 31.12.2019), 222 out of 870 females with H8_EXT_CHOL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXT_CHOL | 1.268 [1.01, 1.6] | 0.043 |
| Birth year | 0.99 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 225 out of 883 males with H8_EXT_CHOL died.
Mortality risk
Mortality risk for people of age
years, who have H8_EXT_CHOL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.122% | 0.26% |
| 5 | 0.774% | 1.499% |
| 10 | 2.0% | 3.783% |
| 15 | 3.865% | 7.259% |
| 20 | 6.95% | 12.422% |
Relationships between endpoints
↥Index endpoint: H8_EXT_CHOL – Cholesteatoma of external ear
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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