esophageal disease: A non-neoplastic or neoplastic disorder that affects the esophagus. Representative examples of non-neoplastic disorders include esophagitis and esophageal ulcer. Representative examples of neoplastic disorders include carcinomas, lymphomas, and melanomas.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
187 |
4. Check minimum number of eventsNone |
187 |
5. Include endpointsNone |
187 |
6. Filter based on genotype QC (FinnGen only) |
180 |
Control definitions (FinnGen only)
- Control exclude
- K11_OESSTODUO
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K22
- Name in latin
- Perforatio oesophagi
Similar endpoints
↥List of similar endpoints to
Perforation of oesophagus
based on the number of shared cases.
Similar with more cases:
- Diseases of oesophagus, stomach and duodenum
- Gastrointestinal diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1531 | 568 | 942 |
| Only index persons | 1177 | 448 | 729 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.03 |
| Only index persons | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 65.20 | 69.78 | 62.30 |
| Only index persons | 64.77 | 68.22 | 62.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 180 | 70 | 110 |
| Unadjusted period prevalence (%) | 0.04 | 0.02 | 0.05 |
| Median age at first event (years) | 64.29 | 63.93 | 64.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 187
- Matched controls
- 1870
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K22.3
ICD-10 Finland
Perforation of oesophagus
+∞
253.9
181
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
31.0
122.8
147
198
JCF12
NOMESCO Finland
Endoscopic insertion of prosthetic tube into oesphagus
336.9
69.3
66
*
R13
ICD-10 Finland
Dysphagia
15.2
54.6
55
50
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
689.7
54.4
51
*
K22.2
ICD-10 Finland
Oesophageal obstruction
+∞
48.0
44
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
86.8
47.0
51
8
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
201.8
46.1
46
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
12.8
45.1
50
52
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
110.7
40.8
43
5
UJC12
NOMESCO Finland
Flexible oesophagoscopy
252.6
40.6
40
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
17.0
39.3
35
25
R4190
NOMESCO Finland
Nutritional therapy
18.0
38.3
33
22
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.7
36.3
84
203
JDB10
NOMESCO Finland
Percutaneous gastrostomy
65.3
32.7
37
7
UJD02
NOMESCO Finland
Gastroscopy
34.7
30.4
39
14
JCE00
NOMESCO Finland
Suture of oesophagus
+∞
26.7
25
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.5
26.0
43
72
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
33.0
25.5
33
12
JCA08
NOMESCO Finland
Endoscopic removal of foreign body from oesophagus
143.4
24.2
25
*
A02BC05
ATC
esomeprazole; systemic
4.6
24.1
111
448
K22.1
ICD-10 Finland
Ulcer of oesophagus
+∞
22.3
21
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
7.2
22.2
37
62
WX872
NOMESCO Finland
Intensive care
7.6
21.7
34
53
TJD20
NOMESCO Finland
Change of gastrostomy tube
123.9
21.0
22
*
ZXD05
NOMESCO Finland
Urgent procedure
3.9
18.6
89
354
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.0
18.3
127
646
JCB00
NOMESCO Finland
Oesophagostomy
+∞
18.0
17
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
7.8
17.5
26
38
GD1AD
NOMESCO Finland
Thorax CT examination
6.7
17.3
30
52
WX892
NOMESCO Finland
Monitored bed care
6.0
17.2
34
67
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
14.1
17.0
29
24
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.0
16.7
63
211
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
7.7
16.1
24
35
T18.1
ICD-10 Finland
Foreign body in oesophagus
65.9
16.1
18
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.6
16.0
77
302
K22.0
ICD-10 Finland
Achalasia of cardia
+∞
15.8
15
*
JDB00
NOMESCO Finland
Gastrostomy
+∞
15.8
15
*
K20
ICD-10 Finland
Oesophagitis
173.9
15.7
16
*
UJC02
NOMESCO Finland
Rigid oesophagoscopy
42.0
15.7
19
5
WX402
NOMESCO Finland
General anaesthesia
3.8
15.6
62
214
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.6
14.7
40
104
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.7
14.6
61
217
ZXE00
NOMESCO Finland
One hour or less
3.2
14.1
100
490
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.3
14.1
31
67
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.3
13.8
81
355
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
5.4
13.3
29
62
TPH07
NOMESCO Finland
Cathetrisation of artery
4.3
13.3
39
107
ZXE30
NOMESCO Finland
More than five and less than seven hours
6.8
13.3
22
36
JCC10
NOMESCO Finland
Transthoracic partial oesophagectomy without interposition
75.1
12.8
14
*
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
26.5
12.7
17
7
JAH00
NOMESCO Finland
Laparotomy
10.8
12.7
24
25
A02BC02
ATC
pantoprazole; systemic
3.6
12.7
146
929
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
16.1
12.1
19
13
JN4BD
NOMESCO Finland
Extensive body CT
3.8
12.0
42
131
A03FA01
ATC
metoclopramide; systemic, rectal
3.2
11.8
60
238
J01MA12
ATC
levofloxacin; systemic
3.3
11.8
55
207
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
11.7
63
258
JN4AD
NOMESCO Finland
Body CT examination
4.0
11.6
38
113
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.5
11.5
48
168
N03AX16
ATC
[U] pregabalin
3.2
11.5
59
235
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
13.9
11.4
19
15
RD210, ,
NOMESCO Finland
21.7
11.3
16
8
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
21.7
11.3
16
8
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
19.3
10.9
16
9
J01MA14
ATC
moxifloxacin; systemic
4.3
10.8
31
83
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
5.3
10.8
23
48
Z98.8
ICD-10 Finland
Other specified postsurgical states
63.7
10.8
12
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
10.6
69
313
K22.8
ICD-10 Finland
Other specified diseases of oesophagus
+∞
10.5
10
*
JDB01
NOMESCO Finland
Laparoscopic gastrostomy
+∞
10.5
10
*
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
+∞
10.5
10
*
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
11.0
10.3
19
19
A02BC03
ATC
lansoprazole; oral
2.9
10.0
65
293
C15.5
ICD-10 Finland
Malignant neoplasm: Lower third of oesophagus
21.5
10.0
14
7
GAB10
NOMESCO Finland
Antero- or postero-lateral thoracotomy
58.1
9.8
11
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.9
9.7
31
90
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.5
9.7
38
127
A02BA04
ATC
nizatidine; systemic
4.8
9.6
23
53
Z3226
NOMESCO Finland
Physiotherapist
3.0
9.5
52
213
JCE96
NOMESCO Finland
Other reconstruction of oesophagus
+∞
9.4
9
*
D84
ICPC
Oesophagus disease
+∞
9.4
9
*
TJF00
NOMESCO Finland
Insertion of jejunal tube
+∞
9.4
9
*
K92.0
ICD-10 Finland
Haematemesis
16.7
9.2
14
9
C15.9
ICD-10 Finland
Malignant neoplasm: Oesophagus, unspecified
38.7
9.1
11
*
WX002
NOMESCO Finland
Sedation and analgesia
2.9
9.1
52
217
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
19.8
9.1
13
7
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
25.5
9.0
12
5
R4110
NOMESCO Finland
Physiotherapy
2.7
9.0
70
343
ZXE20
NOMESCO Finland
More than three and less than five hours
3.2
9.0
41
150
JN3AD
NOMESCO Finland
Abdominal CT examination
3.6
8.7
32
102
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.2
8.7
40
147
JCC12
NOMESCO Finland
Thoracoscopic or laparoscopic partial oesophagectomy
94.1
8.5
9
*
K22.9
ICD-10 Finland
Disease of oesophagus, unspecified
94.1
8.5
9
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.5
8.5
32
104
JCA98
NOMESCO Finland
Other local endoscopic operation on oesophagus
+∞
8.4
8
*
JCF00
NOMESCO Finland
Insertion of prosthetic tube into oesphagus
+∞
8.4
8
*
JCC96
NOMESCO Finland
Other partial oesophagectomy
+∞
8.4
8
*
5304A
ICD-9 Finland
Diseases of oesophagus, Perforation of oesophagus
+∞
8.4
8
*
JCD03
NOMESCO Finland
Subcutaneous anastomosis of oesophagus with interposition of intestine
+∞
8.4
8
*
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
+∞
8.4
8
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
12.5
8.2
14
12
GBB00
NOMESCO Finland
Tracheostomy
18.2
8.2
12
7
N05CF01
ATC
zopiclone; oral
2.5
8.1
77
412
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
5.0
8.1
18
39
UJC01
NOMESCO Finland
Scopy of lower throat
13.9
8.0
13
10
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
11.5
7.9
14
13
J45.9
ICD-10 Finland
Asthma, unspecified
2.9
7.9
44
180
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.9
7.9
45
187
WX704
NOMESCO Finland
Intubation
4.1
7.6
22
59
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
8.2
7.6
16
21
Z43.1
ICD-10 Finland
Attention to gastrostomy
83.3
7.5
8
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
10.0
7.4
14
15
K22.6
ICD-10 Finland
Gastro-oesophageal laceration-haemorrhage syndrome
+∞
7.3
7
*
JBC00
NOMESCO Finland
Gastro-oesophageal antireflux operation
+∞
7.3
7
*
1310
FHL
Esophagogastroscopy
+∞
7.3
7
*
K22.5
ICD-10 Finland
Diverticulum of oesophagus, acquired
+∞
7.3
7
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
12.7
7.2
12
10
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
4.7
7.1
17
39
N05AH04
ATC
quetiapine; oral
2.8
7.1
41
171
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.0
7.0
21
58
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
6.6
7.0
17
28
X59
ICD-10 Finland
Exposure to unspecified factor
2.7
6.9
44
193
A28
ICPC
Limited function/disability NOS
2.6
6.7
44
196
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
6.6
80
468
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.9
6.6
35
139
J98.5
ICD-10 Finland
Diseases of mediastinum, not elsewhere classified
72.2
6.5
7
*
JAH01
NOMESCO Finland
Laparoscopy
6.4
6.5
16
27
T36
ICD-10 Finland
Poisoning by systemic antibiotics
7.5
6.3
14
20
N02AA05
ATC
oxycodone; systemic
2.5
6.3
46
214
X58
ICD-10 Finland
Exposure to other specified factors
2.8
6.3
34
136
JCW96
NOMESCO Finland
Other operations on oesophagus
+∞
6.3
6
*
JDA55
NOMESCO Finland
Endoscopic dilatation of stomach, pylorus or anastomosis of stomach
+∞
6.3
6
*
J86.09
ICD-10 Finland
Pyothorax with fistula
+∞
6.3
6
*
T05
ICPC
Feeding problem of adult
27.7
6.3
8
*
UJF32
NOMESCO Finland
Coloscopy
2.3
6.1
55
283
WZC00
NOMESCO Finland
Treatment plan or consultation
2.2
6.1
73
423
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
51
123
5.33
20.92
5.6
6.6
8.05
9.97
mmol/l
1.24
51
114
122
625
3.74
16.90
8.8
4.3
32.00
35.48
g/l
6.78
117
589
41
100
4.97
16.36
2.0
1.6
—
—
—
0
0
57
184
4.02
15.80
16.6
6.3
104.96
103.93
mmol/l
0.67
57
184
77
338
3.17
12.90
5.9
2.5
—
—
—
0
0
61
233
3.40
12.87
2.1
2.0
—
—
—
0
0
43
136
3.81
12.02
3.4
2.1
0.18
0.21
g/l
2.72
43
127
124
747
2.96
11.22
14.4
6.2
1.20
1.21
mmol/l
1.18
112
620
125
758
2.96
11.14
15.0
13.1
1.31
1.27
inr
0.17
32
209
48
179
3.26
10.31
20.9
6.4
2.30
1.19
mmol/l
1.27
43
139
114
684
2.71
9.94
13.1
5.7
1.19
1.21
mmol/l
2.32
109
618
44
161
3.27
9.71
1.7
1.9
—
—
—
0
0
47
180
3.15
9.61
21.5
6.3
12.45
11.61
kpa
0.48
47
170
47
180
3.15
9.61
21.5
6.3
5.44
5.09
kpa
1.48
47
170
44
164
3.20
9.40
1.8
2.0
—
—
—
0
0
110
677
2.52
8.68
6.0
2.5
—
—
—
0
0
61
285
2.69
8.59
4.3
3.3
99.78
323.73
ng/l
0.99
49
230
68
352
2.46
7.61
2.7
1.9
2.99
3.19
mg/l
0.30
58
302
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
19
46
4.48
7.47
3.2
2.1
0.25
0.36
u/ml
—
9
20
32
117
3.09
6.97
2.9
2.6
19.77
33.55
u/l
3.57
26
95
93
569
2.26
6.95
2.5
1.9
85.61
95.11
pmol/l
1.44
56
309
26
89
3.23
6.29
22.4
5.9
26.35
24.32
mmol/l
2.15
26
89
22
69
3.48
6.09
2.9
3.6
25.96
24.14
mmol/l
1.16
22
69
14
22
6.79
5.98
1.4
1.4
—
—
—
0
0
117
825
2.12
5.69
13.9
9.7
4.85
4.11
e9/l
2.05
103
732
31
125
2.77
5.64
1.8
2.1
369.00
355.11
nmol/l
0.10
26
114
79
483
2.10
5.62
3.2
3.3
2.30
2.35
mmol/l
1.97
71
431
52
272
2.26
5.46
2.5
1.7
1114.03
1302.44
nmol/l
0.78
43
203
23
84
2.98
4.99
1.8
1.8
—
—
—
0
0
41
202
2.32
4.91
2.5
2.3
16.46
22.53
%
2.43
36
185
69
426
1.98
4.61
3.5
3.1
0.25
0.49
e6/l
1.09
59
329
47
252
2.16
4.58
2.4
2.1
29.47
29.25
s
0.11
47
242
11
19
6.08
4.51
1.4
1.5
—
—
—
0
0
11
19
6.08
4.51
1.4
1.5
—
—
—
0
0
51
288
2.06
4.33
1.8
1.7
2.19
1.39
mg/l
0.51
41
228
82
546
1.89
4.32
3.5
3.2
—
—
—
0
0
14
37
4.00
3.99
2.1
1.6
—
—
—
0
0
8
11
7.54
3.90
3.8
2.4
—
—
—
0
0
82
568
1.79
3.66
3.4
2.4
138.76
174.81
ug/l
0.76
77
515
23
100
2.48
3.60
11.2
7.1
25.23
24.18
mmol/l
0.71
23
92
57
355
1.87
3.58
1.7
1.5
22.53
20.85
nmol/l
0.37
52
297
86
612
1.75
3.45
4.0
3.7
22.23
53.78
ng/l
2.68
71
449
13
38
3.60
3.39
1.7
1.2
—
—
—
0
0
8
15
5.52
3.22
1.0
1.3
572.25
224.15
u/l
—
8
15
21
93
2.42
3.17
4.3
3.8
3.74
2.31
mmol/l
0.95
16
72
27
136
2.15
3.04
1.9
3.5
61.97
65.96
g/l
1.53
27
123
11
32
3.59
2.95
2.1
2.4
7.04
7.48
kpa
0.41
11
32
28
148
2.05
2.79
3.4
5.3
3.80
34.26
ug/l
0.57
23
126
5
6
8.52
2.76
1.4
1.0
—
—
—
0
0
126
1034
1.67
2.71
3.3
3.6
14.93
14.97
pmol/l
0.06
118
914
12
43
2.91
2.70
4.8
2.3
1.19
1.67
mg/l
2.14
12
38
44
275
1.78
2.67
3.9
3.2
2.47
2.45
mmol/l
0.67
37
250
10
30
3.46
2.64
1.4
1.6
—
—
—
0
0
22
112
2.09
2.42
3.2
2.2
84.40
62.03
ml/min/173m2
—
5
40
13
52
2.61
2.41
2.5
1.8
—
—
—
0
0
11
40
2.86
2.32
1.5
1.2
—
—
—
0
0
6
13
4.73
2.29
1.0
1.1
—
—
—
0
0
13
54
2.51
2.25
3.2
2.1
—
—
—
0
0
13
55
2.47
2.17
2.3
2.3
—
—
—
0
0
19
96
2.09
2.14
1.9
1.3
—
—
—
0
0
28
165
1.82
2.05
5.3
3.3
—
—
—
0
0
10
38
2.72
2.04
1.9
2.5
25.71
25.44
mmol/l
—
10
38
39
254
1.68
2.03
3.0
2.8
1.63
0.88
e6/l
0.50
22
146
6
17
3.61
1.85
3.8
4.9
—
—
—
0
0
37
244
1.64
1.84
3.1
2.9
1.42
1.08
e6/l
0.33
20
138
6
21
2.92
1.52
2.0
1.8
—
—
—
0
0
6
22
2.78
1.44
2.0
1.8
—
—
—
0
0
6
22
2.78
1.44
2.0
1.8
—
—
—
0
0
10
47
2.19
1.36
1.6
1.7
—
—
—
0
0
97
821
1.38
1.36
2.6
2.7
—
—
—
0
0
8
34
2.41
1.31
1.8
1.7
—
—
—
0
0
136
1479
0.70
1.27
4.5
4.5
1.48
1.43
mmol/l
0.53
122
1338
141
1524
0.70
1.27
5.1
5.1
2.50
2.68
mmol/l
1.60
130
1382
160
1489
1.52
1.19
40.8
13.9
38.63
23.86
mg/l
5.08
155
1169
5
20
2.54
1.16
2.2
1.8
—
—
—
0
0
12
66
1.87
1.12
1.1
2.5
2.87
3.00
g/l
0.27
12
60
5
21
2.42
1.09
2.2
1.8
—
—
—
0
0
5
21
2.42
1.09
2.2
1.8
—
—
—
0
0
5
21
2.42
1.09
1.0
1.4
—
—
—
0
0
138
1487
0.73
1.08
4.6
4.5
4.40
4.55
mmol/l
0.98
127
1356
7
33
2.16
1.06
1.0
1.1
23.87
26.75
u/l
—
7
27
12
69
1.79
0.99
1.1
2.4
7.33
7.32
g/l
0.01
12
63
12
69
1.79
0.99
1.1
2.4
3.35
3.52
g/l
0.29
12
63
12
69
1.79
0.99
1.1
2.4
—
—
—
0
0
11
62
1.82
0.96
1.1
2.5
8.25
10.44
g/l
1.85
11
55
132
1422
0.76
0.93
5.6
5.8
39.16
40.28
mmol/mol
0.89
127
1315
26
187
1.45
0.91
3.2
5.2
217.73
236.21
u/l
0.87
26
176
6
30
2.03
0.87
1.0
1.4
—
—
—
0
0
10
58
1.77
0.81
1.1
2.6
37.25
37.92
g/l
—
10
52
6
34
1.79
0.77
1.2
1.6
291.00
311.15
mu/l
—
6
34
6
107
0.55
0.75
1.2
1.7
—
—
—
0
0
5
24
2.11
0.75
1.2
1.3
—
—
—
0
0
60
696
0.80
0.72
5.0
5.0
2.06
2.53
ug/l
0.41
52
626
7
41
1.73
0.70
1.1
1.7
—
—
—
0
0
13
189
0.66
0.68
1.4
1.3
15.11
19.56
u/ml
—
8
82
7
43
1.65
0.67
1.3
1.2
0.25
0.25
g/l
—
7
43
141
1328
1.25
0.62
4.4
4.2
1.83
2.02
mu/l
1.30
131
1184
82
732
1.21
0.62
3.5
3.4
0.00
0.00
estimate
-0.00
20
139
81
723
1.21
0.61
3.6
3.5
0.00
0.00
estimate
-0.00
21
157
10
149
0.65
0.59
1.1
1.4
—
—
—
0
0
81
726
1.20
0.58
4.9
4.6
0.00
0.00
estimate
-0.00
20
147
5
88
0.56
0.57
1.0
2.0
—
—
—
0
0
41
484
0.80
0.56
3.5
3.9
12.06
9.67
mg/mmol
0.09
28
312
34
410
0.79
0.56
3.0
3.1
0.69
0.72
ug/l
0.07
29
277
48
554
0.82
0.53
3.4
4.5
19.13
21.31
%
0.53
26
278
9
64
1.43
0.52
1.2
1.0
—
—
—
0
0
6
40
1.52
0.52
1.8
1.3
—
—
—
0
0
6
40
1.52
0.52
1.5
1.4
—
—
—
0
0
7
46
1.54
0.49
1.3
1.2
1.05
1.20
g/l
—
7
46
7
46
1.54
0.49
1.9
1.7
—
—
—
0
0
6
93
0.63
0.43
1.2
2.2
—
—
—
0
0
8
56
1.45
0.43
1.1
2.0
27.96
36.08
u/l
—
8
48
0
16
0.00
0.41
0.0
3.6
—
—
—
0
0
13
97
1.37
0.40
3.0
3.6
99.31
85.10
ng/l
0.22
13
85
5
35
1.44
0.39
1.2
1.8
—
—
—
0
0
137
1423
0.86
0.36
4.4
4.0
1.19
1.30
mmol/l
1.54
123
1284
164
1672
0.84
0.26
56.3
20.3
37.14
40.59
%
8.31
150
1571
0
11
0.00
0.21
0.0
1.2
—
11.05
—
0
11
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
3.9
—
—
—
0
0
0
12
0.00
0.21
0.0
2.5
—
13.89
—
0
12
0
12
0.00
0.21
0.0
1.5
—
3.50
—
0
6
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
111
1070
1.09
0.20
4.7
3.8
17.75
12.38
mm/h
2.03
106
986
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
17
191
0.88
0.14
1.4
1.5
—
—
—
0
0
60
577
1.06
0.10
3.8
3.6
—
—
—
0
0
5
44
1.14
0.10
1.0
1.2
—
—
—
0
0
5
44
1.14
0.10
1.0
1.2
—
—
—
0
0
143
1449
0.94
0.09
4.8
4.6
5.84
6.05
mmol/l
1.52
137
1309
43
414
1.05
0.07
3.8
3.6
0.00
0.00
estimate
-0.00
20
138
19
193
0.98
0.00
9.3
7.6
—
—
—
0
0
142
1423
0.99
0.00
33.3
13.8
84.56
78.82
ml/min/173m2
2.04
130
1163
41
405
1.02
0.00
3.0
2.9
10958.44
2657.21
umol/l
0.35
36
354
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
68
0.88
-0.00
1.2
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_PERFOES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PERFOES | 2.851 [2.1, 3.87] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.097 |
During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 359 females with K11_PERFOES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PERFOES | 3.71 [2.7, 5.09] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.097 |
During the follow-up period (1.1.1998 — 31.12.2019), 293 out of 605 males with K11_PERFOES died.
Mortality risk
Mortality risk for people of age
years, who have K11_PERFOES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.263% | 0.671% |
| 5 | 1.521% | 4.559% |
| 10 | 3.626% | 11.643% |
| 15 | 7.001% | 21.535% |
| 20 | 12.095% | 35.304% |
Relationships between endpoints
↥Index endpoint: K11_PERFOES – Perforation of oesophagus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data