No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
229 |
4. Check minimum number of eventsNone |
229 |
5. Include endpointsNone |
229 |
6. Filter based on genotype QC (FinnGen only) |
224 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L60
- Name in latin
- Dystrophia unguium
Similar endpoints
↥List of similar endpoints to
Nail dystrophy
based on the number of shared cases.
Similar with more cases:
- Nail disorders
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1588 | 915 | 667 |
| Only index persons | 1462 | 851 | 611 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 45.42 | 50.45 | 38.41 |
| Only index persons | 45.88 | 50.41 | 39.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 224 | 132 | 92 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | 53.62 | 53.41 | 53.93 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 229
- Matched controls
- 2290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L60.3
ICD-10 Finland
Nail dystrophy
16384.0
291.1
214
*
L60.0
ICD-10 Finland
Ingrowing nail
7.2
18.4
29
45
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.8
17.0
44
109
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.2
16.6
38
85
B35.1
ICD-10 Finland
Tinea unguium
5.4
15.5
33
69
D01BA02
ATC
terbinafine; oral
3.2
15.4
86
361
QDH00
NOMESCO Finland
Avulsion of toe nail
159.8
14.6
15
*
L60.9
ICD-10 Finland
Nail disorder, unspecified
20.8
14.5
21
11
QCH00
NOMESCO Finland
Avulsion of finger nail
+∞
13.7
13
*
S22
ICPC
Nail symptom/complaint
4.8
13.4
33
78
L40.0
ICD-10 Finland
Psoriasis vulgaris
6.3
12.0
21
36
D01AE16
ATC
amorolfine; topical
3.5
10.9
43
143
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.9
10.7
61
253
Z2221
NOMESCO Finland
Medical doctor
2.6
10.1
79
385
D07AD01
ATC
clobetasol; topical
3.0
9.7
52
207
Z3229
NOMESCO Finland
Other healthcare associate professional
3.6
8.9
32
100
RJ421, ,
NOMESCO Finland
52.0
8.7
10
*
RJ420, ,
NOMESCO Finland
34.7
8.1
10
*
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.6
8.1
20
47
Z3231
NOMESCO Finland
Registered nurse
2.3
8.0
79
421
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
3.1
7.7
35
126
H02AB07
ATC
prednisone; oral
3.0
7.7
38
144
E0000UV, ,
ATC
2.2
7.7
105
639
Z3226
NOMESCO Finland
Physiotherapist
2.5
7.5
56
262
QDH01
NOMESCO Finland
Excision of nail bed in toe
82.7
7.5
8
*
UJF30
NOMESCO Finland
Ileoscopy through colon
3.0
7.3
34
124
70300
ICD-8 Finland
Diseases of nail, Dystrophia unguium
+∞
7.3
7
*
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.3
7.2
29
97
L60.1
ICD-10 Finland
Onycholysis
20.8
7.2
10
5
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
7.0
40
164
J02AC02
ATC
itraconazole; systemic
2.5
7.0
53
250
ZXA05
NOMESCO Finland
Left side
2.2
6.5
65
345
D07AC01
ATC
betamethasone; topical
2.1
6.5
91
551
R4110
NOMESCO Finland
Physiotherapy
2.1
6.3
75
425
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
6.3
112
736
7038A
ICD-9 Finland
Diseases of nail, Other specified diseases of nail[DYSTROPHIA UNGUIUM]
+∞
6.3
6
*
J01FF01
ATC
clindamycin; systemic
2.1
6.2
70
390
R03DC03
ATC
montelukast; oral
2.4
6.1
45
208
WX892
NOMESCO Finland
Monitored bed care
3.4
6.0
22
69
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
125
788
2.29
8.66
5.8
4.4
35.23
35.62
g/l
0.30
113
746
116
759
2.07
6.78
2.7
2.2
81.35
76.01
nmol/l
1.04
103
664
65
343
2.25
6.60
3.4
3.2
179.87
136.01
ng/l
0.18
46
256
38
174
2.42
5.27
2.3
2.3
37.29
30.35
u/l
0.52
31
144
18
55
3.47
5.14
1.6
2.0
—
—
—
0
0
10
12
8.65
5.11
1.0
1.3
6.08
8.66
u/l
—
5
12
125
898
1.86
5.06
10.7
7.0
1.22
1.22
mmol/l
0.33
113
764
176
1418
2.04
4.96
5.1
3.9
13.93
11.77
mm/h
1.18
163
1294
29
123
2.55
4.72
2.6
2.6
77.34
135.58
ng/l
1.32
29
110
20
70
3.03
4.62
1.4
2.3
—
—
—
0
0
81
520
1.86
4.58
1.8
1.7
1.30
1.37
mmol/l
0.32
74
429
144
1101
1.83
4.58
10.4
9.5
3.96
4.09
e9/l
0.25
127
972
146
1130
1.81
4.36
5.9
5.0
6.42
6.63
mmol/l
0.57
133
1039
52
292
2.01
4.35
3.0
2.8
1.31
2.76
e6/l
1.10
28
157
216
1929
3.11
4.19
17.8
13.4
29.43
22.23
mg/l
1.83
185
1486
98
683
1.76
4.15
3.0
2.9
—
—
—
0
0
67
418
1.85
4.09
3.2
2.0
2.42
3.16
mg/l
1.99
58
356
101
719
1.72
3.91
2.3
1.9
101.75
97.01
pmol/l
0.33
45
338
112
824
1.70
3.82
9.1
6.1
1.22
1.22
mmol/l
0.24
104
757
13
35
3.87
3.65
1.5
1.5
—
—
—
0
0
13
35
3.87
3.65
1.5
1.5
—
—
—
0
0
43
244
1.94
3.46
2.6
2.1
25.49
22.70
%
0.27
36
206
52
316
1.84
3.40
3.0
2.7
0.71
1.12
e6/l
0.85
28
177
10
23
4.50
3.35
1.1
1.2
—
—
—
0
0
10
23
4.50
3.35
1.1
1.2
—
—
—
0
0
106
792
1.63
3.26
4.4
2.4
75.62
110.30
ug/l
3.58
100
720
14
49
2.98
3.25
1.5
1.6
0.02
0.08
iu/ml
—
5
9
10
24
4.31
3.23
1.1
1.2
—
—
—
0
0
10
24
4.31
3.23
1.1
1.2
—
—
—
0
0
10
24
4.31
3.23
1.1
1.2
—
—
—
0
0
13
40
3.38
3.20
1.2
1.2
—
—
—
0
0
76
527
1.66
3.11
3.0
2.9
0.26
0.38
e6/l
0.31
60
391
8
16
5.14
3.08
1.3
1.1
—
—
—
0
0
35
193
1.96
3.06
1.6
1.8
—
—
—
0
0
5
5
10.18
2.99
1.0
1.6
—
—
—
0
0
35
198
1.91
2.84
1.6
1.8
—
—
—
0
0
127
1014
1.57
2.82
6.5
6.5
10.46
10.54
umol/l
0.04
121
955
46
285
1.77
2.80
1.6
1.8
—
—
—
0
0
23
113
2.15
2.73
1.3
1.2
252.52
135.18
iu/ml
0.52
12
47
7
15
4.78
2.61
1.0
1.0
—
—
—
0
0
213
1961
2.23
2.56
20.1
15.6
139.33
139.79
mmol/l
1.91
208
1903
169
1462
1.60
2.48
4.8
3.8
14.45
14.85
pmol/l
1.31
157
1311
197
1777
1.78
2.39
5.7
4.5
1.96
1.89
mu/l
0.34
182
1612
11
39
2.91
2.38
1.5
1.3
—
—
—
0
0
111
889
1.48
2.26
2.6
2.7
—
—
—
0
0
83
627
1.51
2.25
4.2
3.0
2.33
2.36
mmol/l
1.06
73
547
13
54
2.49
2.24
3.6
2.7
—
—
—
0
0
11
42
2.70
2.17
1.4
1.1
—
—
—
0
0
8
25
3.28
2.11
1.0
1.1
—
—
—
0
0
67
491
1.52
2.07
2.2
2.7
341.58
7809.84
umol/l
2.40
62
426
7
20
3.58
2.07
2.6
4.1
—
—
—
0
0
73
545
1.50
2.07
1.8
2.0
169.59
177.09
u/l
0.07
68
512
32
196
1.74
2.03
12.1
10.5
2.47
1.36
mmol/l
0.72
24
161
8
26
3.15
2.03
1.0
1.1
—
—
—
0
0
76
575
1.48
2.01
3.9
3.6
2.92
11.12
mg/mmol
2.86
50
366
5
11
4.62
1.95
1.2
1.2
—
—
—
0
0
12
53
2.33
1.84
1.2
1.5
31.69
23.90
iu/l
0.29
12
48
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
12
4.23
1.83
1.0
1.3
—
—
—
0
0
57
414
1.50
1.82
2.5
1.9
1.04
1.08
mg/l
0.06
45
315
9
35
2.63
1.82
1.7
1.4
—
—
—
0
0
60
442
1.48
1.79
2.6
2.4
—
—
—
0
0
37
532
0.64
1.74
3.6
3.9
0.00
0.01
estimate
0.50
15
189
7
24
2.97
1.73
1.1
1.0
—
—
—
0
0
44
309
1.52
1.64
1.5
1.3
20.10
10.14
u/ml
—
10
117
6
20
3.05
1.59
1.2
1.2
—
—
—
0
0
57
428
1.44
1.54
1.5
1.5
19.13
21.47
nmol/l
0.65
52
352
5
15
3.38
1.53
1.0
1.3
1.95
1.74
mmol/l
—
5
15
192
1772
1.52
1.52
6.3
5.6
39.82
39.87
mmol/mol
0.03
181
1643
13
65
2.06
1.52
2.1
2.1
63.08
374.77
ug/l
2.23
13
60
6
21
2.91
1.51
1.2
3.0
—
10.88
—
0
6
6
21
2.91
1.51
1.2
1.3
—
—
—
0
0
223
2152
2.38
1.45
26.4
19.7
4.51
4.52
e12/l
0.15
218
2096
216
2055
1.90
1.45
14.6
10.2
26.74
26.95
u/l
0.05
210
1973
6
22
2.77
1.44
1.0
1.1
—
—
—
0
0
11
53
2.13
1.41
1.0
1.2
—
—
—
0
0
59
453
1.41
1.40
1.3
1.2
0.80
1.47
u/ml
0.62
11
117
45
329
1.46
1.39
3.9
2.9
2.44
2.46
mmol/l
0.63
36
288
144
1277
1.34
1.34
3.2
3.1
36.83
45.27
u/l
1.57
137
1195
44
325
1.44
1.29
1.4
1.7
920.71
1218.44
nmol/l
2.33
36
239
9
44
2.09
1.28
1.4
1.2
—
—
—
0
0
102
865
1.32
1.28
13.1
12.3
1.18
1.23
inr
0.21
26
263
18
109
1.71
1.23
1.4
1.3
—
42.38
—
0
10
6
26
2.34
1.19
1.0
1.2
—
—
—
0
0
16
95
1.74
1.17
1.3
1.7
—
—
—
0
0
5
20
2.53
1.15
2.0
2.2
—
—
—
0
0
222
2151
2.05
1.13
27.6
19.9
40.16
40.38
%
0.21
204
2018
42
316
1.40
1.12
1.6
1.3
9.90
33.72
iu/ml
—
10
104
198
1866
1.45
1.12
5.3
4.4
5.86
5.94
mmol/l
0.51
185
1693
5
21
2.41
1.09
1.0
2.0
—
—
—
0
0
12
67
1.83
1.07
1.4
1.7
—
—
—
0
0
7
34
2.09
1.03
1.6
1.3
—
—
—
0
0
192
1808
1.38
1.01
15.9
12.9
86.21
83.08
ml/min/173m2
1.09
175
1463
63
758
0.77
1.00
3.5
3.8
—
—
—
0
0
19
125
1.57
0.97
2.4
1.5
—
—
—
0
0
136
1228
1.26
0.96
3.3
3.0
—
—
—
0
0
63
518
1.30
0.95
2.5
3.1
729.03
1178.60
ng/l
1.26
53
434
10
55
1.86
0.93
3.4
2.9
1.70
1.47
mg/l
—
10
50
6
28
2.17
0.92
1.2
1.0
—
—
—
0
0
12
71
1.73
0.90
1.5
1.9
—
—
—
0
0
16
239
0.64
0.90
8.9
6.8
—
—
—
0
0
8
42
1.94
0.89
1.1
1.4
—
—
—
0
0
6
30
2.03
0.87
1.2
1.7
—
—
—
0
0
6
30
2.03
0.87
1.2
1.7
—
—
—
0
0
29
215
1.40
0.86
14.2
7.6
103.93
103.80
mmol/l
0.06
29
215
8
45
1.81
0.85
1.1
1.4
—
—
—
0
0
8
46
1.77
0.83
2.3
1.8
—
—
—
0
0
6
32
1.90
0.82
5.2
3.0
—
981.17
—
0
6
37
291
1.32
0.77
1.7
1.4
—
—
—
0
0
9
54
1.69
0.75
1.3
1.2
—
—
—
0
0
201
1928
1.35
0.74
5.6
4.9
2.67
2.78
mmol/l
1.17
186
1768
10
158
0.62
0.73
2.2
3.7
1.24
1.23
mmol/l
—
10
142
5
26
1.94
0.71
1.2
1.1
—
—
—
0
0
198
1902
1.30
0.66
5.0
4.3
4.58
4.69
mmol/l
0.88
184
1753
26
201
1.33
0.62
2.1
2.1
—
—
—
0
0
8
50
1.62
0.62
1.1
1.4
—
—
—
0
0
8
51
1.59
0.61
2.3
1.4
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
6
35
1.73
0.58
1.3
1.2
—
—
—
0
0
8
54
1.50
0.58
1.4
1.2
—
—
—
0
0
8
54
1.50
0.58
3.1
4.0
—
2.71
—
0
10
38
314
1.25
0.57
4.1
2.8
0.63
0.77
ug/l
0.86
31
196
8
55
1.47
0.56
3.4
4.2
39.54
70.83
mg/l
—
8
42
44
371
1.23
0.55
2.0
1.5
—
—
—
0
0
14
101
1.41
0.51
19.6
6.4
26.74
25.09
mmol/l
0.72
14
101
196
1895
1.24
0.50
4.9
4.3
1.46
1.49
mmol/l
0.33
181
1741
7
48
1.47
0.47
1.1
1.5
—
—
—
0
0
46
397
1.20
0.47
1.8
1.8
406.50
449.57
pmol/l
0.78
36
328
5
32
1.57
0.42
1.2
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.48
0.40
3.0
3.9
56.00
59.18
%
—
5
34
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
103
962
1.13
0.37
5.5
5.0
0.00
0.00
estimate
-0.00
15
191
12
90
1.35
0.36
3.2
1.9
—
—
—
0
0
5
76
0.65
0.36
1.4
2.1
—
—
—
0
0
26
219
1.21
0.35
2.5
2.2
—
—
—
0
0
6
44
1.37
0.34
1.2
1.5
—
—
—
0
0
14
109
1.30
0.34
1.0
1.0
—
—
—
0
0
103
971
1.11
0.30
3.5
3.8
0.00
0.00
estimate
-0.00
14
187
102
962
1.11
0.30
3.5
3.7
0.00
0.00
estimate
0.50
16
205
23
196
1.19
0.28
3.6
4.6
15.92
27.61
ug/l
0.19
15
165
7
95
0.73
0.22
1.1
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.3
—
93.62
—
0
13
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
3.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
52
1.16
0.19
1.2
1.5
—
—
—
0
0
16
184
0.86
0.18
2.6
1.6
—
—
—
0
0
64
605
1.08
0.17
2.4
2.5
74.24
54.68
u/l
0.44
59
553
22
202
1.10
0.11
2.1
3.3
—
—
—
0
0
13
115
1.14
0.11
3.8
1.9
—
—
—
0
0
5
44
1.14
0.10
1.4
1.6
—
—
—
0
0
5
48
1.04
0.09
1.4
1.9
—
—
—
0
0
70
722
0.96
0.08
2.3
3.7
27.20
33.11
ng/l
0.32
38
503
6
57
1.05
0.08
1.2
1.1
—
20.84
—
0
8
11
108
1.02
0.00
28.8
9.9
93.20
94.36
%
0.50
11
108
24
238
1.01
0.00
4.2
4.3
39.60
31.85
%
1.86
15
150
42
424
0.99
0.00
5.1
4.3
22.61
21.53
%
0.19
25
196
182
1819
1.00
0.00
4.6
3.9
1.34
1.28
mmol/l
0.47
163
1665
11
107
1.03
0.00
1.3
1.4
—
—
—
0
0
11
107
1.03
0.00
1.3
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
9
98
0.92
0.00
2.7
2.7
1.72
1.30
%
—
9
98
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
5.86
—
0
5
5
52
0.96
-0.00
1.8
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
8.89
—
0
6
0
7
0.00
-0.00
0.0
2.6
—
214.86
—
0
7
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_NAIL_DYSTROPHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_DYSTROPHY | 1.491 [1.13, 1.97] | 0.005 |
| Birth year | 0.99 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 782 females with L12_NAIL_DYSTROPHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_DYSTROPHY | 1.187 [0.87, 1.62] | 0.285 |
| Birth year | 0.988 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 524 males with L12_NAIL_DYSTROPHY died.
Mortality risk
Mortality risk for people of age
years, who have L12_NAIL_DYSTROPHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.129% | 0.238% |
| 5 | 0.734% | 1.34% |
| 10 | 1.892% | 3.472% |
| 15 | 3.565% | 6.6% |
| 20 | 6.123% | 11.305% |
Relationships between endpoints
↥Index endpoint: L12_NAIL_DYSTROPHY – Nail dystrophy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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