No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
182 |
4. Check minimum number of eventsNone |
182 |
5. Include endpointsNone |
182 |
6. Filter based on genotype QC (FinnGen only) |
178 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M72
Similar endpoints
↥List of similar endpoints to
Necrotizing fasciitis
based on the number of shared cases.
Similar with more cases:
- Fibroblastic disorders
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 969 | 395 | 574 |
| Only index persons | 953 | 390 | 563 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | - | 66.29 | 56.91 |
| Only index persons | 60.76 | 66.30 | 56.93 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 178 | 71 | 107 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | 63.55 | 67.81 | 60.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 182
- Matched controls
- 1820
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M72.6
ICD-10 Finland
Necrotizing fasciitis
+∞
260.1
181
*
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
88.7
158.4
88
19
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
34.0
103.3
74
36
QBB05
NOMESCO Finland
Revision of wound of skin of trunk
74.4
95.6
53
10
ZZA00
NOMESCO Finland
Split skin graft
36.0
93.7
64
27
A46
ICD-10 Finland
Erysipelas
17.1
87.5
113
159
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
14.6
77.2
114
188
S97
ICPC
Chronic ulcer skin
19.0
74.8
70
58
TQW11
NOMESCO Finland
Vacuum treatment of wound
122.0
61.8
64
8
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
22.4
53.2
42
24
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
19.7
52.0
44
29
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
14.3
50.7
53
51
SPAT1148
SPAT
Treatment of chronic ulcer or burn
9.6
47.9
75
124
TPH07
NOMESCO Finland
Cathetrisation of artery
9.5
45.2
69
110
A41.9
ICD-10 Finland
Sepsis, unspecified
16.8
44.0
40
30
ZXD05
NOMESCO Finland
Urgent procedure
7.6
42.0
116
341
QDA10
NOMESCO Finland
Incision of skin of lower limb
180.6
41.7
42
*
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
17.3
37.5
33
23
S18
ICPC
Laceration/cut
7.0
33.5
136
539
WX402
NOMESCO Finland
General anaesthesia
6.4
33.2
81
204
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
6.5
33.2
77
185
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
10.6
32.7
40
47
A49.9
ICD-10 Finland
Bacterial infection, unspecified
7.0
30.5
58
114
WX872
NOMESCO Finland
Intensive care
10.1
29.3
37
45
QBA10
NOMESCO Finland
Incision of skin of trunk
64.2
28.2
32
6
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
7.5
27.1
45
76
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
10.0
27.1
34
41
A10AB05
ATC
insulin aspart; parenteral
7.4
25.2
42
71
J01FF01
ATC
clindamycin; systemic
4.9
24.5
83
267
C03CA01
ATC
furosemide; systemic
4.7
23.9
96
351
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
6.2
23.0
47
97
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
7.0
22.6
39
68
A10AE04
ATC
insulin glargine; parenteral
6.1
22.3
46
96
WX730
NOMESCO Finland
Conventional respirator
86.9
21.2
23
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
6.2
21.2
42
84
Z3231
NOMESCO Finland
Registered nurse
4.3
21.1
84
300
WX320
NOMESCO Finland
Spinalanesthesy
4.4
20.2
73
241
R4120
NOMESCO Finland
Occupational therapy
7.6
19.9
31
48
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
5.5
19.2
44
100
ZXA05
NOMESCO Finland
Left side
4.2
18.5
68
226
A28
ICPC
Limited function/disability NOS
4.6
17.9
54
154
R4110
NOMESCO Finland
Physiotherapy
3.8
17.5
81
314
NFQ20
NOMESCO Finland
Amputation of femur
99.4
16.9
18
*
SPAT1255
SPAT
Intravenous administration of medicine
6.7
16.8
29
50
WX408
NOMESCO Finland
General anesthesy, balanced
3.8
16.3
73
275
N17.9
ICD-10 Finland
Acute renal failure, unspecified
13.0
15.9
28
25
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.1
15.9
38
89
N03AX16
ATC
[U] pregabalin
3.9
15.3
58
194
L17
ICPC
Foot/toe symptom/complaint
3.6
15.2
71
273
ZXE10
NOMESCO Finland
More than one and less than three hours
3.4
15.1
92
418
JFG10
NOMESCO Finland
Closure of loop colostomy without resection
62.1
15.1
17
*
L03.9
ICD-10 Finland
Cellulitis, unspecified
23.5
15.0
21
10
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
12.0
14.8
27
26
ZXA00
NOMESCO Finland
Right side
3.5
14.8
73
290
L28
ICPC
Limited function/disability (L)
4.1
14.7
49
149
ZXE20
NOMESCO Finland
More than three and less than five hours
4.2
14.5
46
135
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
5.9
14.4
28
54
103
Kela drug reimbursment
Diabetes, insulin-treated
3.4
14.2
77
323
JFF23
NOMESCO Finland
Transversostomy
26.3
14.1
19
8
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.4
13.9
72
293
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
13.9
110
577
JN3AD
NOMESCO Finland
Abdominal CT examination
4.5
13.9
39
104
N02AA05
ATC
oxycodone; systemic
3.9
13.9
51
166
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
6.3
13.8
25
45
A40.0
ICD-10 Finland
Sepsis due to streptococcus, group A
150.8
13.6
14
*
J01CF05
ATC
flucloxacillin; systemic
5.8
13.6
27
53
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
43.6
13.4
16
*
T90
ICPC
Diabetes non-insulin dependent
3.4
13.4
68
273
SPAT1149
SPAT
Suture or treatment of traumatic wound
4.1
13.2
43
128
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
19.1
12.8
19
11
NHQ40
NOMESCO Finland
Amputation of toe
26.6
12.7
17
7
SPAT1151
SPAT
Treatment of major wounds
26.6
12.7
17
7
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
5.4
12.6
27
57
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
17.5
12.4
19
12
C03DA01
ATC
spironolactone; oral
4.1
12.4
39
113
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
6.3
12.3
22
39
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.4
12.3
35
94
ZXE00
NOMESCO Finland
One hour or less
3.0
12.2
90
445
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.9
12.1
42
130
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
5.5
12.1
25
51
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.2
11.9
64
263
B01AB05
ATC
enoxaparin; parenteral
3.1
11.9
76
345
WX002
NOMESCO Finland
Sedation and analgesia
3.5
11.8
51
183
L03.3
ICD-10 Finland
Cellulitis of trunk
24.9
11.8
16
7
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
5.5
11.6
24
49
N02AX02
ATC
tramadol; systemic, rectal
2.9
11.5
90
456
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
11.3
57
225
B01AB10
ATC
tinzaparin; parenteral
4.2
11.1
33
91
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
5.7
11.1
22
43
S76
ICPC
Skin infection other
5.5
11.1
23
47
J01MA12
ATC
levofloxacin; systemic
3.3
11.0
53
203
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
6.1
11.0
20
36
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.9
10.9
26
60
Z93.3
ICD-10 Finland
Colostomy status
23.2
10.9
15
7
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
12.3
10.8
19
17
SPAT1262
SPAT
Handing over of treatment supplies
3.3
10.8
50
187
QD9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in lower extremities, unspecified
63.8
10.8
12
*
I50.9
ICD-10 Finland
Heart failure, unspecified
3.5
10.6
42
142
J01MA02
ATC
ciprofloxacin; systemic
2.8
10.6
89
463
C07AB07
ATC
bisoprolol; oral
2.8
10.4
110
642
WX306
NOMESCO Finland
Lumbar epidural anesthesy
9.3
10.4
21
25
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.4
10.4
45
161
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.4
10.3
43
150
Z2221
NOMESCO Finland
Medical doctor
2.9
10.1
63
278
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
5.0
10.1
23
51
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.0
10.0
32
93
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
14.5
9.9
16
12
N05AH04
ATC
quetiapine; oral
3.3
9.8
44
160
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.9
9.8
62
275
QB9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in torso, unspecified
58.2
9.8
11
*
Z3226
NOMESCO Finland
Physiotherapist
3.3
9.7
45
167
M79.6
ICD-10 Finland
Pain in limb
2.8
9.7
72
348
X59
ICD-10 Finland
Exposure to unspecified factor
3.1
9.7
48
186
205
Kela drug reimbursment
Chronic hypertension
2.9
9.6
61
272
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.4
9.5
26
67
TK800
NOMESCO Finland
Hemodialysis
11.6
9.5
17
16
C08CA01
ATC
amlodipine; oral
2.6
9.4
91
500
J01DB01
ATC
cefalexin; oral
4.0
9.3
161
1194
A06AD11
ATC
lactulose; oral
3.4
9.2
39
137
Z2446
NOMESCO Finland
Social worker
4.6
9.0
23
56
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
10.3
9.0
17
18
ZX120
NOMESCO Finland
Intravenous
4.1
8.9
27
75
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
8.9
8.8
18
22
A10BA02
ATC
metformin; oral
2.6
8.7
70
349
A10AC01
ATC
insulin (human); parenteral
4.2
8.7
25
67
E0000UV, ,
ATC
2.5
8.7
86
474
WZC30
NOMESCO Finland
Teaching
3.1
8.7
44
172
NK1XE
NOMESCO Finland
Other ultrasound examinnation of muscle or tendon
21.3
8.6
12
6
H02AB06
ATC
prednisolone; systemic
2.5
8.6
95
551
A02BC02
ATC
pantoprazole; systemic
2.7
8.5
132
895
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
94.2
8.5
9
*
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
94.2
8.5
9
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.6
8.4
21
50
AA1AD
NOMESCO Finland
CT of head and brain
2.7
8.4
63
302
A48.0
ICD-10 Finland
Gas gangrene
+∞
8.4
8
*
JN4AD
NOMESCO Finland
Body CT examination
3.6
8.4
30
94
ZXA10
NOMESCO Finland
Bilateral
3.0
8.3
43
170
A10AE05
ATC
insulin detemir; parenteral
4.5
8.2
21
51
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
9.6
8.2
16
18
NGM10
NOMESCO Finland
Fasciotomy of of knee or lower leg
35.1
8.2
10
*
TPH40
NOMESCO Finland
Insertion of a long peripheral venous catheter
35.1
8.2
10
*
WX213
NOMESCO Finland
Lower leg blockade
35.1
8.2
10
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
7.2
8.1
19
29
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
6.7
8.1
20
33
QCB05
NOMESCO Finland
Revision of wound of skin of upper limb
23.3
8.1
11
5
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.0
8.1
43
172
N06AX21
ATC
duloxetine; oral
4.0
7.9
24
67
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.8
7.9
26
77
N02BE01
ATC
paracetamol; systemic, rectal
4.7
7.9
169
1338
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
4.9
7.8
18
40
ZXD35
NOMESCO Finland
Usual procedure
7.3
7.8
18
27
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
7.8
60
291
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
12.6
7.7
13
11
PD4CG
NOMESCO Finland
Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
19.4
7.7
11
6
QDE35
NOMESCO Finland
Repair of skin defect in lower limb after surgery or injury
26.3
7.7
10
*
PE1AT
NOMESCO Finland
Femoral artery PTA
26.3
7.7
10
*
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
3.2
7.6
33
117
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.4
7.6
29
95
ZXD10
NOMESCO Finland
Scheduled procedure
2.4
7.6
77
424
L89
ICD-10 Finland
Decubitus ulcer and pressure area
14.2
7.5
12
9
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.5
7.5
66
340
A41.8
ICD-10 Finland
Other specified sepsis
9.0
7.5
15
18
ZZR30
NOMESCO Finland
Flap of muscle
83.3
7.5
8
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
6.8
7.5
18
29
B01AF02
ATC
apixaban; oral
3.2
7.4
33
119
A10BJ02
ATC
liraglutide; parenteral
7.9
7.4
16
22
WX750
NOMESCO Finland
Hyperbaric oxygen therapy
+∞
7.3
7
*
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
+∞
7.3
7
*
A10BJ06
ATC
semaglutide; parenteral
6.1
7.3
19
34
ZZR00
NOMESCO Finland
Flap of skin
8.5
7.3
15
19
PD4CC
NOMESCO Finland
Very extensive arterigography of lower extremity with X-ray
31.4
7.2
9
*
XF600
NOMESCO Finland
Bloodpressure measurement
4.2
7.2
20
52
N18.8
ICD-10 Finland
Other chronic renal failure
9.4
7.2
14
16
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.5
7.2
26
82
J45.9
ICD-10 Finland
Asthma, unspecified
2.8
7.1
40
164
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.6
7.1
25
77
R60.0
ICD-10 Finland
Localized oedema
3.4
7.1
28
93
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.3
7.1
86
507
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.7
7.1
24
72
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.8
7.1
23
67
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
7.2
7.0
16
24
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
14.5
7.0
11
8
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.8
7.0
22
63
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
4.6
6.9
17
40
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.3
6.9
28
95
TNG34
NOMESCO Finland
Major custom moulded orthopaedic cast, knee or lower leg
17.5
6.8
10
6
S91.1
ICD-10 Finland
Open wound of toe(s) without damage to nail
41.6
6.8
8
*
A10BB12
ATC
glimepiride; oral
3.8
6.8
22
64
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
8.3
6.8
14
18
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
6.7
66
354
R50.9
ICD-10 Finland
Fever, unspecified
2.8
6.7
37
150
N03AX12
ATC
[U] gabapentin; oral
2.9
6.7
34
132
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
12.9
6.7
11
9
WX882
NOMESCO Finland
High dependency care
10.6
6.6
12
12
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.6
6.6
16
26
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.5
6.5
52
254
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
5.9
6.5
17
31
PE1YT
NOMESCO Finland
Femoral or popliteal artery PTA with stent
15.0
6.5
10
7
XF400
NOMESCO Finland
ECG with 12 standard connections
2.7
6.4
40
173
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
11.6
6.4
11
10
A40.8
ICD-10 Finland
Other streptococcal sepsis
11.6
6.4
11
10
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.0
6.4
19
52
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
6.3
33
130
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.0
6.3
31
118
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
27.7
6.3
8
*
WX704
NOMESCO Finland
Intubation
3.9
6.2
19
53
TKC20
NOMESCO Finland
Catheterisation of bladder
3.6
6.2
21
63
L04AX01
ATC
azathioprine; systemic
7.1
6.2
14
21
160
Kela drug reimbursment
exenatide
10.6
6.1
11
11
E66.00
ICD-10 Finland
Metabolic syndrome
4.3
6.0
16
40
I48.1
ICD-10 Finland
Persistent atrial fibrillation
5.7
6.0
16
30
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
45
38
15.40
46.36
3.6
1.4
—
—
—
0
0
41
31
16.78
44.89
2.2
1.5
—
—
—
0
0
83
168
8.24
43.88
15.3
11.6
1.48
1.22
mmol/l
0.14
75
136
56
72
10.79
43.44
11.7
8.7
23.84
24.65
mmol/l
0.50
56
72
63
95
9.61
43.08
16.9
11.1
93.30
93.87
%
0.22
63
95
82
168
8.06
42.72
15.5
11.6
11.42
12.70
kpa
1.61
82
159
82
168
8.06
42.72
15.5
11.6
5.28
5.08
kpa
0.85
82
156
71
143
7.50
37.03
16.9
13.1
110.86
120.42
g/l
2.48
71
137
69
147
6.95
33.75
2.2
1.8
—
—
—
0
0
83
212
6.36
33.58
2.2
1.8
—
—
—
0
0
67
146
6.68
31.85
2.2
1.6
—
—
—
0
0
75
187
6.12
30.81
16.9
8.1
102.97
104.81
mmol/l
1.84
75
187
61
128
6.66
29.97
7.1
3.3
1.99
1.77
mmol/l
0.12
53
103
61
141
6.00
26.82
7.3
3.5
—
—
—
0
0
40
60
8.26
26.71
6.0
3.8
23.93
23.53
mmol/l
0.20
40
60
133
609
5.40
24.93
5.0
2.6
—
—
—
0
0
49
99
6.40
24.66
2.3
1.6
—
—
—
0
0
88
304
4.67
23.53
3.1
1.9
3.76
3.17
mg/l
1.17
80
254
99
383
4.48
22.57
5.4
2.9
1.00
0.38
e6/l
1.50
84
286
114
496
4.48
21.97
6.1
3.0
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
29
41
8.22
20.13
3.0
2.2
0.35
0.31
u/ml
0.13
18
17
86
324
4.14
19.82
4.7
2.5
—
—
—
0
0
134
690
4.57
19.67
19.3
7.9
1.16
1.21
mmol/l
5.91
121
582
37
74
6.02
18.53
4.9
2.5
0.68
0.67
%
0.09
37
74
37
75
5.94
18.27
4.9
2.5
1.59
1.11
%
1.12
37
75
25
36
7.89
17.00
1.3
1.1
—
—
—
0
0
37
85
5.21
15.83
1.8
1.2
—
—
—
0
0
138
794
4.05
15.71
16.0
10.0
5.96
4.16
e9/l
6.45
125
699
105
524
3.37
14.64
4.9
2.4
260.17
154.14
ug/l
0.54
98
470
121
662
3.47
14.40
26.3
13.2
1.16
1.30
inr
1.52
43
197
143
883
3.89
13.72
7.5
3.9
—
179.77
—
0
13
63
238
3.52
13.67
4.3
2.6
0.86
1.31
e6/l
0.71
39
128
24
23
11.84
13.21
1.5
1.0
—
—
—
0
0
24
23
11.84
13.21
1.5
1.0
—
—
—
0
0
36
94
4.53
13.10
15.5
12.1
25.89
24.62
mmol/l
1.12
36
86
80
360
3.18
12.92
3.4
2.8
390.51
12992.47
umol/l
2.85
70
309
66
276
3.18
11.93
2.4
1.5
1.75
1.53
mg/l
0.29
57
212
57
219
3.33
11.85
4.4
2.7
2.87
2.16
e6/l
0.24
34
113
20
18
12.32
11.37
4.0
3.2
15.07
16.50
%
—
12
9
20
21
10.55
10.57
3.5
1.7
67.21
68.96
%
0.11
20
21
25
60
4.67
10.00
1.3
1.6
1.80
1.55
g/l
0.61
25
50
113
685
2.71
9.65
6.1
3.2
0.00
0.01
estimate
0.50
37
131
113
686
2.71
9.61
6.1
3.2
0.00
0.00
estimate
-0.00
33
117
93
515
2.65
9.51
2.2
1.8
94.07
94.94
pmol/l
0.06
55
263
20
26
8.50
9.43
5.7
3.6
4.80
4.98
kpa
0.42
20
26
111
678
2.63
9.16
7.8
4.3
0.00
0.00
estimate
-0.00
36
124
93
529
2.55
8.81
2.7
2.2
70.50
77.15
nmol/l
1.34
87
471
26
71
4.11
8.81
2.0
1.8
—
—
—
0
0
80
429
2.54
8.53
5.7
3.8
28.99
7.82
mg/mmol
1.40
65
274
76
400
2.55
8.40
3.3
3.3
3573.80
1146.63
ng/l
1.41
70
335
19
43
4.82
8.11
2.0
2.6
71.70
80.93
mg/l
0.09
12
34
19
43
4.82
8.11
2.0
2.7
38.15
31.96
mg/l
0.21
11
34
19
45
4.60
7.68
2.1
1.2
—
—
—
0
0
68
355
2.46
7.50
7.4
3.7
0.00
0.01
estimate
0.50
33
122
43
183
2.77
7.16
2.3
1.8
1.91
1.44
%
1.18
37
160
14
17
8.82
6.97
2.6
2.2
2.08
1.52
mmol/l
1.36
14
17
15
22
7.33
6.67
1.5
1.5
—
—
—
0
0
13
16
8.65
6.45
2.3
2.8
30.23
33.87
pg
1.88
13
16
12
14
9.08
6.16
2.3
2.1
89.38
90.39
%
0.26
12
14
17
44
4.16
6.14
2.9
2.6
—
—
—
0
0
24
81
3.26
5.94
5.0
4.5
4.67
1.50
mmol/l
3.69
12
66
16
32
5.38
5.72
1.4
1.2
—
—
—
0
0
9
7
13.43
5.64
2.0
1.4
—
—
—
0
0
16
33
5.21
5.58
1.4
1.2
—
—
—
0
0
18
53
3.66
5.46
1.4
1.4
—
—
—
0
0
15
40
4.00
5.21
1.6
1.7
—
—
—
0
0
15
40
4.00
5.21
1.6
1.7
—
—
—
0
0
84
546
2.00
4.95
4.8
3.6
68.70
43.40
ng/l
0.76
73
384
47
247
2.22
4.85
3.8
3.0
2.47
2.44
mmol/l
0.54
41
226
12
22
5.76
4.69
4.4
2.3
117.50
135.31
g/l
1.56
12
16
9
11
8.54
4.61
1.2
1.1
—
—
—
0
0
11
20
5.78
4.36
6.5
3.5
62.55
55.60
%
0.48
11
20
33
157
2.35
4.27
5.7
3.0
6.14
6.73
umol/l
0.17
28
142
7
7
10.33
4.04
1.9
2.3
9.14
13.57
%
—
7
7
15
48
3.32
4.03
4.0
1.9
—
—
—
0
0
80
545
1.83
3.85
6.8
3.3
—
—
—
0
0
47
269
2.01
3.82
1.3
1.2
0.78
1.02
u/ml
0.41
11
71
7
8
9.04
3.80
1.9
2.1
—
—
—
0
0
24
104
2.51
3.79
2.7
2.7
43.93
59.86
ml/min/173m2
1.25
14
36
6
5
12.34
3.79
2.0
1.8
98.17
64.20
%
—
6
5
16
56
3.04
3.73
10.3
14.5
1.74
1.68
%
0.10
16
49
7
9
8.03
3.59
1.1
1.2
664.00
301.30
iu/ml
—
7
9
128
1022
1.85
3.51
7.3
3.5
25.00
11.91
mm/h
6.65
121
926
57
359
1.86
3.46
1.8
1.7
1.93
1.39
mmol/l
1.20
52
293
11
27
4.27
3.46
2.8
1.4
—
—
—
0
0
7
10
7.23
3.39
4.0
2.4
1156.14
1094.10
u/ml
—
7
10
12
33
3.82
3.36
1.5
1.7
—
—
—
0
0
9
20
4.68
3.15
1.7
1.5
—
—
—
0
0
10
25
4.17
3.13
1.6
1.6
—
—
—
0
0
33
178
2.04
3.13
21.3
7.9
—
—
—
0
0
169
1512
2.65
3.05
64.9
15.7
138.09
139.75
mmol/l
11.64
169
1467
5
5
10.23
2.99
2.0
1.2
—
—
—
0
0
169
1517
2.60
2.93
65.3
15.7
4.06
3.99
mmol/l
2.60
169
1470
5
6
8.52
2.76
1.4
1.0
—
—
—
0
0
7
14
5.15
2.75
1.1
1.6
—
—
—
0
0
46
290
1.78
2.73
1.5
1.8
833.77
427.70
pmol/l
0.55
39
247
8
19
4.35
2.71
1.4
1.7
—
—
—
0
0
8
19
4.35
2.71
1.4
1.7
—
—
—
0
0
8
19
4.35
2.71
1.4
1.2
—
—
—
0
0
5
7
7.30
2.56
1.6
1.1
—
—
—
0
0
11
37
3.10
2.53
2.4
1.4
—
—
—
0
0
9
26
3.59
2.52
1.3
1.8
—
—
—
0
0
9
26
3.59
2.52
1.3
1.8
—
—
—
0
0
6
13
4.73
2.29
1.7
3.7
—
—
—
0
0
6
14
4.39
2.17
2.0
1.4
—
—
—
0
0
6
14
4.39
2.17
1.8
1.0
—
—
—
0
0
9
31
3.00
2.10
1.8
1.7
—
—
—
0
0
6
15
4.10
2.05
1.3
1.0
—
—
—
0
0
6
15
4.10
2.05
2.3
2.6
—
—
—
0
0
9
33
2.81
1.96
1.1
1.7
—
—
—
0
0
5
11
4.64
1.95
1.0
1.1
—
—
—
0
0
5
11
4.64
1.95
1.8
4.2
—
—
—
0
0
5
11
4.64
1.95
1.2
1.7
—
—
—
0
0
8
28
2.94
1.88
1.8
1.7
—
—
—
0
0
6
17
3.61
1.85
1.5
1.5
—
—
—
0
0
5
12
4.25
1.83
1.4
1.2
—
—
u/ml
—
0
0
8
29
2.84
1.81
1.5
1.7
—
—
—
0
0
8
29
2.84
1.81
1.3
1.2
—
—
—
0
0
8
33
2.49
1.55
1.8
1.5
—
—
—
0
0
5
15
3.40
1.53
1.0
2.1
—
—
—
0
0
5
15
3.40
1.53
1.8
2.5
—
—
—
0
0
5
15
3.40
1.53
6.8
2.2
—
—
—
0
0
5
15
3.40
1.53
1.0
2.1
—
—
—
0
0
5
15
3.40
1.53
1.0
2.1
—
—
—
0
0
5
16
3.18
1.44
1.2
1.3
118.00
111.38
%
—
5
16
6
22
2.78
1.44
1.7
1.0
—
—
—
0
0
6
23
2.66
1.38
1.2
1.0
—
—
—
0
0
23
148
1.63
1.28
4.5
4.7
50.55
55.09
ug/l
0.03
18
123
8
37
2.21
1.23
2.1
1.3
—
—
—
0
0
5
19
2.68
1.22
1.2
1.2
—
—
—
0
0
6
26
2.35
1.19
1.5
1.2
—
—
—
0
0
6
26
2.35
1.19
1.7
1.7
—
—
—
0
0
5
20
2.54
1.16
1.0
1.1
—
—
—
0
0
26
179
1.53
1.11
1.1
1.2
1.49
18.90
u/ml
1.70
11
74
8
41
1.99
1.10
3.0
2.0
—
—
—
0
0
5
21
2.42
1.10
1.6
1.1
—
—
—
0
0
5
21
2.42
1.10
1.0
1.9
—
—
—
0
0
5
21
2.42
1.10
1.0
1.9
—
—
—
0
0
38
494
0.71
1.08
3.7
4.1
19.57
20.71
%
0.22
13
218
25
351
0.67
1.08
2.4
3.0
0.47
0.86
ug/l
1.92
18
221
7
34
2.10
1.04
1.3
1.4
—
—
—
0
0
11
61
1.85
1.01
1.4
2.5
37.55
38.76
u/l
0.06
11
54
8
145
0.53
0.98
2.3
1.8
—
—
—
0
0
114
1025
1.30
0.93
4.1
3.5
14.63
14.92
pmol/l
0.58
109
898
26
192
1.41
0.81
1.3
1.2
49.27
43.57
iu/ml
—
9
61
6
34
1.79
0.77
3.3
1.9
—
—
—
0
0
149
1404
1.34
0.76
50.9
12.4
77.56
81.04
ml/min/173m2
0.64
132
1175
95
854
1.24
0.70
3.5
2.7
—
—
—
0
0
8
51
1.59
0.61
1.5
2.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
184.01
—
0
22
169
1642
1.41
0.51
77.7
19.6
36.82
40.84
%
12.79
161
1543
14
103
1.39
0.47
1.9
2.0
—
—
—
0
0
169
1647
1.37
0.44
74.7
19.4
121.03
138.01
g/l
23.18
169
1617
11
149
0.72
0.42
1.1
1.4
—
—
—
0
0
54
598
0.86
0.37
3.8
4.6
2.16
2.83
ug/l
0.32
45
537
147
1419
1.19
0.36
4.7
4.0
1.58
1.32
mmol/l
1.83
132
1300
6
45
1.34
0.34
1.5
2.0
—
—
—
0
0
146
1415
1.16
0.30
5.1
4.4
7.53
6.01
mmol/l
5.77
136
1286
149
1451
1.15
0.26
4.7
4.4
1.26
1.42
mmol/l
4.78
134
1333
152
1483
1.15
0.25
5.8
4.9
2.45
2.78
mmol/l
4.15
137
1364
14
115
1.24
0.24
1.9
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
149
1460
1.11
0.18
5.0
4.4
4.25
4.64
mmol/l
4.26
135
1352
5
67
0.74
0.17
1.0
1.5
55.80
39.73
nmol/l
—
5
67
24
218
1.12
0.14
1.4
1.3
—
—
—
0
0
14
156
0.89
0.10
2.1
2.0
10.94
13.53
nmol/l
0.83
14
147
5
47
1.07
0.09
1.6
1.6
—
—
—
0
0
7
65
1.08
0.08
1.0
1.1
—
—
—
0
0
7
65
1.08
0.08
1.6
2.3
19.57
62.28
u/ml
—
7
60
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
69.83
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint M13_NECROFASC and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_NECROFASC | 4.252 [2.17, 8.33] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.118 |
During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 352 males with M13_NECROFASC died.
Mortality risk
Mortality risk for people of age
years, who have M13_NECROFASC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.782% |
| 5 | No data | 4.842% |
| 10 | No data | 13.347% |
| 15 | No data | 24.441% |
| 20 | No data | 38.97% |
Relationships between endpoints
↥Index endpoint: M13_NECROFASC – Necrotizing fasciitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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