No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
158 |
4. Check minimum number of eventsNone |
158 |
5. Include endpointsNone |
158 |
6. Filter based on genotype QC (FinnGen only) |
158 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M72
Similar endpoints
↥List of similar endpoints to
Necrotizing fasciitis
based on the number of shared cases.
Similar with more cases:
- Fibroblastic disorders
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 969 | 395 | 574 |
| Only index persons | 953 | 390 | 563 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | - | 66.29 | 56.91 |
| Only index persons | 60.76 | 66.30 | 56.93 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 158 | 60 | 98 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 63.78 | 68.83 | 60.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 136
- Matched controls
- 1359
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M72.6
ICD-10 Finland
Necrotizing fasciitis
+∞
196.5
136
*
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
140.1
65.5
66
9
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
47.7
51.8
63
24
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
16.6
44.4
85
124
ZZA00
NOMESCO Finland
Split skin graft
50.1
42.8
51
16
A46
ICD-10 Finland
Erysipelas
16.0
42.5
81
114
TQW11
NOMESCO Finland
Vacuum treatment of wound
60.8
41.9
48
12
S97
ICPC
Chronic ulcer skin
29.4
37.3
51
27
QBB05
NOMESCO Finland
Revision of wound of skin of trunk
83.7
34.1
37
6
ZXD05
NOMESCO Finland
Urgent procedure
9.6
32.3
93
249
QDA10
NOMESCO Finland
Incision of skin of lower limb
72.9
26.2
29
5
SPAT1148
SPAT
Treatment of chronic ulcer or burn
9.4
24.4
57
97
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
8.0
22.3
58
115
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
14.6
22.0
38
35
S18
ICPC
Laceration/cut
6.2
22.0
92
343
TPH07
NOMESCO Finland
Cathetrisation of artery
9.6
21.2
47
71
A41.9
ICD-10 Finland
Sepsis, unspecified
19.5
21.1
32
21
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
24.2
20.6
29
15
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
17.0
20.0
32
24
A49.9
ICD-10 Finland
Bacterial infection, unspecified
9.3
18.6
41
60
Z3231
NOMESCO Finland
Registered nurse
5.5
18.0
68
209
QBA10
NOMESCO Finland
Incision of skin of trunk
49.2
17.9
21
5
WX402
NOMESCO Finland
General anaesthesia
6.1
16.0
49
114
ZXE10
NOMESCO Finland
More than one and less than three hours
4.7
15.8
74
275
R4110
NOMESCO Finland
Physiotherapy
5.0
15.2
60
186
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
9.7
14.9
31
40
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
8.7
14.8
33
48
WX320
NOMESCO Finland
Spinalanesthesy
5.3
14.7
52
142
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
9.0
14.7
32
45
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
7.9
14.6
35
57
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
23.2
14.3
20
10
R4120
NOMESCO Finland
Occupational therapy
13.0
14.2
25
23
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
8.0
14.1
33
52
J01FF01
ATC
clindamycin; systemic
4.6
14.0
60
199
C03CA01
ATC
furosemide; systemic
4.3
13.5
65
237
N17.9
ICD-10 Finland
Acute renal failure, unspecified
15.2
13.5
22
17
WX408
NOMESCO Finland
General anesthesy, balanced
4.4
13.5
62
219
L03.9
ICD-10 Finland
Cellulitis, unspecified
25.7
13.3
18
8
WX872
NOMESCO Finland
Intensive care
8.5
13.0
29
42
NFQ20
NOMESCO Finland
Amputation of femur
35.9
12.9
16
5
ZXA05
NOMESCO Finland
Left side
4.5
12.9
55
179
L17
ICPC
Foot/toe symptom/complaint
4.6
12.6
51
157
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
7.4
12.3
30
50
L03.3
ICD-10 Finland
Cellulitis of trunk
51.6
12.1
14
*
103
Kela drug reimbursment
Diabetes, insulin-treated
4.0
12.1
60
222
SPAT1149
SPAT
Suture or treatment of traumatic wound
6.0
12.0
35
74
ZXE00
NOMESCO Finland
One hour or less
3.8
11.9
75
335
N03AX16
ATC
pregabalin; oral
4.8
11.9
45
128
NHQ40
NOMESCO Finland
Amputation of toe
33.4
11.9
15
5
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
9.0
11.8
25
33
A10AE04
ATC
insulin glargine; parenteral
5.9
11.6
34
72
J01DB01
ATC
cefalexin; oral
5.8
11.4
124
872
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
6.4
11.4
31
60
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
9.3
11.2
23
29
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.0
11.1
55
198
T90
ICPC
Diabetes non-insulin dependent
4.0
10.9
52
183
ZXA00
NOMESCO Finland
Right side
3.8
10.9
58
223
ZXE20
NOMESCO Finland
More than three and less than five hours
5.0
10.8
37
94
QD9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in lower extremities, unspecified
65.3
10.8
12
*
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
13.6
10.7
18
15
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
35.6
10.5
13
*
A28
ICPC
Limited function/disability NOS
4.5
10.4
40
114
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
10.8
10.2
19
20
N02BE01
ATC
paracetamol; systemic, rectal
5.8
10.0
126
933
SPAT1151
SPAT
Treatment of major wounds
28.5
10.0
13
5
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
28.5
10.0
13
5
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
16.7
9.8
15
10
JFF23
NOMESCO Finland
Transversostomy
19.3
9.6
14
8
WX730
NOMESCO Finland
Conventional respirator
19.3
9.6
14
8
L28
ICPC
Limited function/disability (L)
4.5
9.6
36
100
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.0
9.3
31
76
WX002
NOMESCO Finland
Sedation and analgesia
3.9
9.3
43
145
Z2446
NOMESCO Finland
Social worker
7.8
9.3
21
31
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
9.1
79
421
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
7.1
9.1
22
36
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
6.4
8.8
23
42
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
29.7
8.6
11
*
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
6.5
8.6
22
39
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
14.0
8.6
14
11
WX213
NOMESCO Finland
Lower leg blockade
95.7
8.5
9
*
ZXD10
NOMESCO Finland
Scheduled procedure
3.0
8.4
66
323
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
15.8
8.4
13
9
SPAT1262
SPAT
Handing over of treatment supplies
3.6
8.4
41
144
M79.6
ICD-10 Finland
Pain in limb
3.5
8.3
44
163
N02AA05
ATC
oxycodone; systemic
4.0
8.2
35
109
QDE35
NOMESCO Finland
Repair of skin defect in lower limb after surgery or injury
35.7
8.2
10
*
Z3226
NOMESCO Finland
Physiotherapist
3.9
8.2
36
115
JFG10
NOMESCO Finland
Closure of loop colostomy without resection
23.7
8.2
11
5
B01AB05
ATC
enoxaparin; parenteral
3.0
8.1
57
260
X59
ICD-10 Finland
Exposure to unspecified factor
3.8
8.0
36
117
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.4
7.9
29
78
A40.0
ICD-10 Finland
Sepsis due to streptococcus, group A
47.8
7.8
9
*
NGM10
NOMESCO Finland
Fasciotomy of of knee or lower leg
47.8
7.8
9
*
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
6.0
7.8
21
40
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.2
7.7
48
200
QB9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in torso, unspecified
26.7
7.7
10
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.1
7.6
24
55
C07AB07
ATC
bisoprolol; oral
2.8
7.6
78
442
PD4CC
NOMESCO Finland
Very extensive arterigography of lower extremity with X-ray
84.5
7.5
8
*
C08CA01
ATC
amlodipine; oral
2.8
7.4
62
312
Z2221
NOMESCO Finland
Medical doctor
3.0
7.4
51
225
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
6.3
7.4
19
34
N02AX02
ATC
tramadol; systemic, rectal
2.8
7.3
63
322
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.9
7.3
31
96
A10AE05
ATC
insulin detemir; parenteral
6.1
7.2
19
35
Z93.3
ICD-10 Finland
Colostomy status
31.9
7.2
9
*
J01MA12
ATC
levofloxacin; systemic
3.3
7.1
39
147
A10BA02
ATC
metformin; oral
2.9
7.1
52
239
H02AB06
ATC
prednisolone; systemic
2.7
7.0
71
393
TK800
NOMESCO Finland
Hemodialysis
14.8
7.0
11
8
C03DA01
ATC
spironolactone; oral
4.4
7.0
25
66
R52.0
ICD-10 Finland
Acute pain
11.8
6.9
12
11
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
7.9
6.9
15
21
Z50.1
ICD-10 Finland
Other physical therapy
7.9
6.9
15
21
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
7.1
6.9
16
25
A01
ICPC
Pain general/multiple sites
7.1
6.9
16
25
WX306
NOMESCO Finland
Lumbar epidural anesthesy
7.1
6.9
16
25
PE1YT
NOMESCO Finland
Femoral or popliteal artery PTA with stent
42.2
6.8
8
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.9
6.8
49
222
ZXD35
NOMESCO Finland
Usual procedure
8.5
6.8
14
18
PD4CG
NOMESCO Finland
Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
23.9
6.8
9
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.6
6.7
23
58
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
6.8
6.7
16
26
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
6.8
6.7
16
26
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
6.6
37
142
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
5.3
6.5
19
40
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
10.0
6.4
12
13
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
10.0
6.4
12
13
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
11.8
6.4
11
10
CKC12
NOMESCO Finland
Photocoagulation of retina
6.9
6.4
15
24
TK810
NOMESCO Finland
Hemofiltration
+∞
6.3
6
*
ZZR00
NOMESCO Finland
Flap of skin
8.3
6.3
13
17
EBA15
NOMESCO Finland
Extraction of large number of teeth
8.3
6.3
13
17
SPAT1255
SPAT
Intravenous administration of medicine
4.8
6.3
20
47
B01AC04
ATC
clopidogrel; oral
3.4
6.2
31
109
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
7.3
6.2
14
21
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
9.3
6.2
12
14
J01MA02
ATC
ciprofloxacin; systemic
2.6
6.2
62
334
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
7.9
6.1
13
18
ZXA10
NOMESCO Finland
Bilateral
3.2
6.1
34
130
Mortality – FinRegistry
↥Association
Association between endpoint M13_NECROFASC and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_NECROFASC | 4.252 [2.17, 8.33] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.118 |
During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 352 males with M13_NECROFASC died.
Mortality risk
Mortality risk for people of age
years, who have M13_NECROFASC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.782% |
| 5 | No data | 4.842% |
| 10 | No data | 13.347% |
| 15 | No data | 24.441% |
| 20 | No data | 38.97% |
Relationships between endpoints
↥Index endpoint: M13_NECROFASC – Necrotizing fasciitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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