No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
292 |
4. Check minimum number of eventsNone |
292 |
5. Include endpointsNone |
292 |
6. Filter based on genotype QC (FinnGen only) |
282 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Similar endpoints
↥List of similar endpoints to
Primary amenorrhea
based on the number of shared cases.
Similar with more cases:
- Amenorrhoea
- Irregular menses
- Polycystic ovarian syndrome, consortium definition
- Noninflammatory disorders of female genital tract
- Genitourinary diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 282 | 282 | - |
| Unadjusted period prevalence (%) | 0.10 | 0.10 | - |
| Median age at first event (years) | 16.93 | 16.93 | - |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 292
- Matched controls
- 2920
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N91.0
ICD-10 Finland
Primary amenorrhoea
+∞
307.7
292
*
G03DB01
ATC
dydrogesterone; oral
10.6
88.1
132
210
N91.1
ICD-10 Finland
Secondary amenorrhoea
11.1
59.1
71
82
F50.0
ICD-10 Finland
Anorexia nervosa
14.6
47.2
45
36
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
4.9
34.3
101
285
G03FB08
ATC
dydrogesterone and estrogen; systemic
11.3
32.5
36
36
G03FB06
ATC
medroxyprogesterone and estrogen; systemic
12.3
31.7
33
30
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
8.4
24.7
34
45
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
7.9
23.4
34
48
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
6.4
20.3
36
63
N97.0
ICD-10 Finland
Female infertility associated with anovulation
6.5
19.6
34
58
Q51.0
ICD-10 Finland
Agenesis and aplasia of uterus
191.1
17.7
18
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
14.9
15.8
26
19
F50.9
ICD-10 Finland
Eating disorder, unspecified
5.7
15.0
29
55
E28.3
ICD-10 Finland
Primary ovarian failure
25.3
14.0
19
8
Q52.0
ICD-10 Finland
Congenital absence of vagina
146.5
13.6
14
*
E30.09
ICD-10 Finland
Delayed puberty NOS
146.5
13.6
14
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.0
12.4
67
267
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
3.9
11.0
34
95
Z3226
NOMESCO Finland
Physiotherapist
2.7
10.0
62
264
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
+∞
9.4
9
*
X05
ICPC
Menstruation absent/scanty
3.7
9.0
30
88
N91.2
ICD-10 Finland
Amenorrhoea, unspecified
8.0
8.8
19
25
F50.1
ICD-10 Finland
Atypical anorexia nervosa
8.0
8.8
19
25
G03FB05
ATC
norethisterone and estrogen; systemic
4.2
8.5
23
58
E30.00
ICD-10 Finland
Familial delayed puberty
34.4
8.1
10
*
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.2
7.4
76
403
XLA10, ,
NOMESCO Finland
7.6
7.3
16
22
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.4
7.3
57
270
Z2221
NOMESCO Finland
Medical doctor
2.0
6.9
92
539
G03FB09
ATC
levonorgestrel and estrogen; systemic
14.7
6.4
10
7
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.0
6.4
29
104
Z3231
NOMESCO Finland
Registered nurse
2.0
6.1
81
471
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
95
172
7.70
54.23
2.4
1.5
7.55
8.60
u/l
0.44
78
130
65
111
7.25
38.37
2.1
1.7
0.21
0.40
nmol/l
2.04
59
96
87
215
5.34
34.68
2.3
1.4
7.64
16.26
iu/l
4.16
71
170
82
266
3.90
22.15
1.6
1.5
280.04
301.74
mu/l
0.25
76
234
39
73
6.01
20.57
1.3
1.3
1.80
1.91
nmol/l
0.05
33
65
105
646
1.98
6.83
4.4
4.0
38.28
37.88
g/l
0.32
97
598
133
926
1.80
5.65
2.8
2.3
70.30
69.36
nmol/l
0.19
126
854
92
582
1.85
5.28
2.2
2.3
2.36
2.36
mmol/l
0.04
86
521
111
767
1.72
4.62
6.8
5.8
1.22
1.22
mmol/l
0.01
92
656
102
690
1.74
4.58
5.6
5.2
1.22
1.22
mmol/l
0.07
91
640
238
2042
1.90
4.36
5.2
4.2
14.12
14.25
pmol/l
0.38
219
1868
40
202
2.14
4.33
3.4
2.6
205.18
594.90
ng/l
1.59
31
159
7
6
11.91
4.29
1.3
1.0
1.99
2.27
nmol/l
—
7
6
9
14
6.59
4.01
1.2
1.2
—
—
—
0
0
48
271
1.92
3.83
4.3
4.4
8.42
17.38
mg/mmol
0.81
33
190
155
1211
1.60
3.78
6.6
5.1
32.32
31.16
%
0.86
146
1155
151
1188
1.56
3.47
6.5
5.0
54.02
55.32
%
0.88
142
1132
7
11
6.49
3.20
2.0
1.3
113.71
60.36
nmol/24h
—
7
11
7
12
5.95
3.04
1.1
1.0
11.00
21.25
pmol/l
—
7
12
163
1347
1.48
2.72
10.0
6.8
3.61
3.92
e9/l
0.99
140
1179
254
2322
1.72
2.53
6.2
4.7
1.78
1.72
mu/l
0.49
242
2187
185
1580
1.47
2.52
4.3
3.3
38.07
35.94
mmol/mol
1.71
171
1492
224
1989
1.54
2.51
7.8
6.7
104.30
103.94
ml/min/173m2
0.08
165
1459
57
386
1.59
2.41
1.7
1.3
19.67
19.62
nmol/l
0.01
51
332
66
464
1.55
2.38
1.9
2.3
11.56
13.95
ng/l
0.48
28
146
68
491
1.50
2.16
2.3
2.1
0.75
0.77
mg/l
0.03
44
336
142
1179
1.40
2.12
3.6
3.6
6.21
5.96
mmol/l
0.63
131
996
24
132
1.89
2.11
3.3
5.5
105.38
105.26
mmol/l
0.06
24
132
6
15
4.06
2.05
9.8
9.0
707.67
972.00
nmol/l
—
6
15
6
15
4.06
2.05
15.7
16.7
1223.17
1877.13
nmol/l
—
6
15
89
685
1.43
2.03
1.9
1.6
100.65
95.22
pmol/l
0.57
43
381
9
32
2.87
2.02
1.2
1.5
—
—
—
0
0
40
263
1.60
1.92
2.9
1.9
2.41
2.40
mmol/l
0.29
35
218
8
28
2.91
1.87
1.1
1.1
—
—
—
0
0
8
28
2.91
1.87
1.1
1.1
—
—
—
0
0
8
28
2.91
1.87
1.1
1.1
—
—
—
0
0
8
28
2.91
1.87
1.1
1.1
—
—
—
0
0
8
28
2.91
1.87
1.1
1.1
—
—
—
0
0
72
551
1.41
1.68
4.0
5.6
1.13
1.08
inr
0.26
30
226
107
875
1.35
1.66
5.2
4.4
10.04
9.18
umol/l
0.61
95
802
18
98
1.89
1.65
1.6
1.5
—
—
—
0
0
11
49
2.29
1.65
1.4
1.2
40.61
37.36
nmol/l
0.06
11
43
10
43
2.37
1.60
1.3
1.4
—
—
—
0
0
20
116
1.78
1.53
4.7
4.8
5.43
5.09
kpa
0.57
20
110
164
1441
1.32
1.51
6.7
5.3
75.17
71.63
u/l
0.51
155
1331
20
117
1.76
1.49
1.6
1.8
—
—
—
0
0
200
1811
1.33
1.46
3.2
2.5
1.10
1.09
mmol/l
0.07
186
1716
34
232
1.53
1.42
1.4
1.6
1236.23
1035.85
nmol/l
0.55
27
178
19
112
1.74
1.39
2.5
6.1
24.78
23.67
mmol/l
0.86
19
112
254
2397
1.46
1.36
8.6
6.9
22.69
22.10
u/l
0.20
246
2306
6
24
2.53
1.31
1.2
1.2
—
—
—
0
0
11
55
2.04
1.29
1.6
1.2
—
—
—
0
0
24
155
1.60
1.27
2.5
5.2
3.00
1.18
mmol/l
1.86
19
117
210
1932
1.31
1.26
3.5
2.8
2.67
2.74
mmol/l
0.67
196
1830
7
142
0.48
1.24
2.1
1.5
—
—
—
0
0
33
231
1.48
1.24
3.2
2.1
25.90
250.69
ng/l
—
10
78
8
37
2.19
1.22
3.4
2.0
98.31
158.81
ug/l
—
8
31
176
1593
1.26
1.15
3.5
2.8
54.36
45.73
ug/l
0.97
166
1495
21
312
0.65
1.11
2.2
1.7
—
—
—
0
0
43
324
1.38
1.11
1.3
1.3
50.55
154.91
iu/ml
3.74
12
122
40
298
1.40
1.10
2.0
2.5
0.82
0.77
e6/l
0.05
24
153
7
32
2.22
1.09
1.1
1.1
—
—
—
0
0
209
1947
1.26
0.99
3.7
2.7
5.52
5.40
mmol/l
0.48
186
1794
0
29
0.00
0.98
0.0
1.4
—
285.71
—
0
7
206
1918
1.25
0.97
3.3
2.7
1.58
1.53
mmol/l
0.94
193
1823
284
2777
1.83
0.96
16.9
12.9
38.96
39.39
%
0.74
271
2650
284
2774
1.87
0.95
17.1
13.0
258.51
268.57
e9/l
2.25
279
2703
58
706
0.78
0.94
1.7
1.5
—
—
—
0
0
207
1931
1.25
0.94
3.3
2.7
4.59
4.60
mmol/l
0.01
193
1841
68
564
1.27
0.92
2.6
2.2
54.84
54.94
u/l
0.01
61
513
81
690
1.24
0.87
2.9
2.5
24.87
25.74
u/l
0.29
75
653
30
396
0.73
0.86
1.6
1.5
—
—
—
0
0
100
873
1.22
0.85
1.7
1.4
1.78
2.24
u/ml
0.17
32
229
177
1634
1.21
0.85
3.8
3.4
8.98
8.35
mm/h
0.40
167
1504
25
338
0.72
0.84
2.1
1.6
—
—
—
0
0
23
166
1.42
0.78
2.7
3.0
—
—
—
0
0
37
291
1.31
0.76
2.0
2.6
7.97
5.99
e6/l
0.32
21
146
9
54
1.69
0.75
2.1
3.3
54.11
55.63
%
—
9
54
9
54
1.69
0.75
1.0
1.1
—
—
—
0
0
283
2778
1.61
0.71
17.1
13.0
4.42
4.45
e12/l
0.90
277
2710
5
27
1.87
0.68
1.0
3.6
27.86
11.09
u/ml
—
5
27
5
29
1.74
0.64
1.4
2.1
—
—
—
0
0
37
452
0.79
0.63
1.5
1.4
—
—
—
0
0
11
163
0.66
0.62
1.4
1.3
—
—
—
0
0
22
286
0.75
0.60
1.4
1.4
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
6
35
1.73
0.58
1.5
1.2
—
—
—
0
0
6
35
1.73
0.58
1.5
1.2
—
—
—
0
0
35
422
0.81
0.54
1.3
1.2
1.51
8.44
u/ml
2.32
19
164
17
126
1.37
0.53
2.7
7.4
25.28
24.69
mmol/l
0.25
17
126
235
2422
0.85
0.49
4.2
4.3
—
—
—
0
0
29
352
0.80
0.48
1.4
1.4
—
—
—
0
0
29
352
0.80
0.48
1.4
1.4
—
—
—
0
0
29
352
0.80
0.48
1.4
1.4
—
—
—
0
0
29
351
0.81
0.47
1.4
1.4
—
—
—
0
0
7
48
1.47
0.47
1.1
1.2
—
—
—
0
0
136
1274
1.13
0.44
4.3
4.2
0.00
0.00
estimate
-0.00
32
303
136
1275
1.12
0.43
3.4
3.0
0.00
0.00
estimate
-0.00
33
305
5
32
1.57
0.42
1.4
1.2
—
—
—
0
0
10
70
1.44
0.42
1.3
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
156.86
—
0
15
0
16
0.00
0.41
0.0
1.0
—
90.56
—
0
16
0
17
0.00
0.41
0.0
1.2
—
72.40
—
0
5
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
8
115
0.69
0.37
1.0
1.1
—
5.70
—
0
20
9
69
1.31
0.37
1.3
1.2
—
—
—
0
0
37
322
1.17
0.35
1.5
1.5
238710197.03
47387197.53
pmol/l
0.36
31
287
6
44
1.37
0.34
7.2
9.8
0.52
0.66
%
—
6
44
6
44
1.37
0.34
7.2
9.8
1.50
1.09
%
—
6
44
136
1288
1.10
0.34
3.4
3.1
0.00
0.00
estimate
-0.00
31
299
6
46
1.31
0.33
1.8
1.8
12.58
13.27
%
—
6
46
70
642
1.12
0.32
3.3
3.1
—
—
—
0
0
249
2440
1.14
0.30
9.9
8.8
18.60
18.55
mg/l
0.01
185
1843
18
148
1.23
0.30
1.7
1.6
—
—
—
0
0
71
655
1.11
0.29
2.6
1.8
—
—
—
0
0
69
637
1.11
0.28
2.4
2.2
2.41
2.64
mg/l
0.45
59
544
24
205
1.19
0.28
2.3
3.9
5.72
4.91
umol/l
0.30
18
152
5
73
0.68
0.26
2.8
2.1
—
—
—
0
0
22
188
1.18
0.26
2.8
2.6
38.00
32.74
%
1.65
16
136
15
181
0.82
0.26
1.1
1.2
—
—
—
0
0
9
72
1.26
0.26
1.1
1.7
—
—
—
0
0
18
151
1.20
0.25
1.7
1.6
—
—
—
0
0
9
76
1.19
0.25
1.9
2.1
—
—
—
0
0
5
38
1.32
0.23
2.0
1.9
—
—
—
0
0
58
538
1.10
0.22
2.5
2.8
0.62
0.21
e6/l
0.56
41
393
5
41
1.22
0.22
1.0
1.0
—
—
—
0
0
77
817
0.92
0.22
1.4
1.5
—
—
—
0
0
5
42
1.19
0.21
1.8
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
75
706
1.08
0.21
4.0
3.2
0.00
0.00
estimate
0.50
31
299
85
805
1.08
0.21
2.6
2.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
25
279
0.89
0.18
1.7
1.5
—
—
—
0
0
14
119
1.19
0.18
1.5
1.5
—
—
—
0
0
5
67
0.74
0.17
1.0
1.7
—
—
—
0
0
37
341
1.10
0.16
2.9
2.8
11223.20
1441.60
umol/l
0.42
30
309
8
68
1.18
0.16
1.1
1.3
—
9.70
—
0
11
49
458
1.08
0.16
1.6
1.5
1.48
1.23
mmol/l
1.18
43
408
151
1551
0.95
0.16
3.0
2.7
28.51
25.23
u/l
0.55
143
1482
6
77
0.77
0.16
1.0
1.1
—
—
—
0
0
10
83
1.21
0.15
1.1
1.5
—
—
—
0
0
126
1223
1.05
0.14
2.2
2.5
—
—
—
0
0
108
1116
0.95
0.14
2.4
1.9
—
—
—
0
0
12
138
0.86
0.13
1.4
1.5
—
—
—
0
0
16
142
1.13
0.13
1.9
2.2
—
—
—
0
0
39
415
0.93
0.12
2.2
2.3
12.96
11.84
e6/l
0.06
32
362
40
378
1.07
0.11
1.7
1.9
—
—
—
0
0
5
46
1.09
0.09
1.0
1.1
—
136.67
—
0
15
5
46
1.09
0.09
1.2
1.2
—
—
—
0
0
27
253
1.07
0.09
1.1
1.0
—
—
—
0
0
6
55
1.09
0.09
1.3
1.3
—
—
—
0
0
104
1064
0.96
0.08
2.2
2.3
—
—
—
0
0
11
98
1.13
0.08
1.3
1.5
300.00
206.85
u/ml
—
6
59
25
235
1.07
0.07
1.8
1.7
—
—
—
0
0
113
1151
0.97
0.07
2.4
2.4
—
—
—
0
0
99
970
1.03
0.06
3.6
3.0
—
—
—
0
0
9
104
0.86
0.06
1.3
1.2
—
—
—
0
0
48
466
1.04
0.05
2.6
2.4
3963.67
5132.53
u/l
0.13
18
189
28
268
1.05
0.05
1.3
1.3
—
—
—
0
0
11
101
1.09
0.04
1.8
1.4
—
—
—
0
0
12
129
0.93
0.03
1.3
1.3
—
—
—
0
0
41
420
0.97
0.03
1.2
1.2
11.57
22.99
iu/ml
—
10
121
24
232
1.04
0.02
1.4
1.3
183.54
279.42
miu/ml
0.58
13
112
11
104
1.06
0.01
1.3
1.4
—
—
—
0
0
55
552
1.00
0.00
1.7
1.9
—
—
—
0
0
17
167
1.02
0.00
2.1
2.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
12.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
20.17
—
0
6
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
79
0.88
-0.00
2.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
47.14
—
0
7
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
19.32
—
0
7
9
93
0.97
-0.00
1.3
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
78
0.89
-0.00
2.4
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
0.43
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
1.43
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
6.28
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
1.73
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
1.95
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
2.66
—
0
5
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: N14_PRIMARY_AMENORRHEA – Primary amenorrhea
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).