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This is a non-core endpoint: only basic statistics are computed.

Injury of blood vessels at lower leg level

ST19_INJURY_BLOOD_VESSE_LOWER_LEG_LEVEL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 S85
  • Cause of death: ICD-10 S85

2 out of 7 registries used, show all original rules.

164

4. Check minimum number of events

None

164

5. Include endpoints

None

164

6. Filter based on genotype QC (FinnGen only)

164

Control definitions (FinnGen only)

Control exclude
ST19_INJURI_KNEE_LOWER_LEG

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
S8
Name in latin
Laesio vasorum sanguineorum in regione genus/cruris

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 164 70 94
Unadjusted period prevalence (%) 0.03 0.02 0.04
Median age at first event (years) 52.05 50.74 53.03

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
153
Matched controls
1530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
S85.9
ICD-10 Finland
Injury of unspecified blood vessel at lower leg level
+∞
54.5
49
*
S83.5
ICD-10 Finland
Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
511.3
41.1
39
*
S85.0
ICD-10 Finland
Injury of popliteal artery
+∞
32.4
30
*
NGE35
NOMESCO Finland
Plastic repair of ligament of knee not using prosthetic material, anterior cruciate, arthroscopic
340.0
28.8
28
*
X59
ICD-10 Finland
Exposure to unspecified factor
9.3
27.8
66
115
S85.1
ICD-10 Finland
Injury of (anterior)(posterior) tibial artery
+∞
21.3
20
*
S83.2
ICD-10 Finland
Tear of meniscus, current
127.4
21.2
22
*
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
38.7
21.0
26
8
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
6.0
21.0
71
192
S85.5
ICD-10 Finland
Injury of popliteal vein
+∞
18.1
17
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
9.1
16.2
35
48
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
14.0
15.8
27
23
NGM10
NOMESCO Finland
Fasciotomy of of knee or lower leg
59.1
14.1
16
*
B01AB05
ATC
enoxaparin; parenteral
4.3
13.8
63
216
S82.1
ICD-10 Finland
Fracture of upper end of tibia
+∞
13.7
13
*
S85.8
ICD-10 Finland
Injury of other blood vessels at lower leg level
+∞
13.7
13
*
NGJ70
NOMESCO Finland
External fixation of fracture of knee or lower leg, other or unspecified
+∞
13.7
13
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
7.2
13.6
34
58
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
22.4
12.8
18
9
S83.1
ICD-10 Finland
Dislocation of knee
+∞
12.7
12
*
X58
ICD-10 Finland
Exposure to other specified factors
5.6
12.3
38
85
ZZA00
NOMESCO Finland
Split skin graft
16.8
11.6
18
12
S85.2
ICD-10 Finland
Injury of peroneal artery
+∞
11.6
11
*
S85.3
ICD-10 Finland
Injury of greater saphenous vein at lower leg level
+∞
11.6
11
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
5.8
10.9
32
67
TNG34
NOMESCO Finland
Major custom moulded orthopaedic cast, knee or lower leg
117.7
10.6
11
*
S83.0
ICD-10 Finland
Dislocation of patella
+∞
10.5
10
*
NG4AA
NOMESCO Finland
Lower leg X-ray examination
35.2
10.5
13
*
S83.4
ICD-10 Finland
Sprain and strain involving (fibular)(tibial) collateral ligament of knee
16.4
9.7
15
10
N03AX16
ATC
pregabalin; oral
3.5
9.5
53
203
NG1AD
NOMESCO Finland
Knee CT examination
95.0
8.5
9
*
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
15.6
8.4
13
9
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
7.7
8.0
18
26
S80.1
ICD-10 Finland
Contusion of other and unspecified parts of lower leg
16.1
7.9
12
8
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
12.8
7.7
13
11
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
10.1
7.5
14
15
R4110
NOMESCO Finland
Physiotherapy
2.9
7.4
52
230
S83.7
ICD-10 Finland
Injury to multiple structures of knee
+∞
7.3
7
*
NHJ10
NOMESCO Finland
Internal fixation of fracture of ankle using wire, rod, cerclage or pin
+∞
7.3
7
*
PEH57
NOMESCO Finland
Bypass from femoral artery to popliteal artery below knee
21.2
7.2
10
5
X50
ICD-10 Finland
Overexertion and strenuous or repetitive movements
31.6
7.2
9
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
3.3
7.0
37
133
S81.0
ICD-10 Finland
Open wound of knee
41.9
6.8
8
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
4.1
6.7
26
73
M79.6
ICD-10 Finland
Pain in limb
2.6
6.6
62
321
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
6.5
52
245
S82.6
ICD-10 Finland
Fracture of lateral malleolus
72.7
6.5
7
*
S86.0
ICD-10 Finland
Injury of Achilles tendon
72.7
6.5
7
*
NGU20
NOMESCO Finland
Removal of internal fixation device from knee or lower leg
72.7
6.5
7
*
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
9.9
6.4
12
13
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
11.7
6.4
11
10
NGU10
NOMESCO Finland
Removal of external fixation device from knee or lower leg
+∞
6.3
6
*
W00
ICD-10 Finland
Fall on same level involving ice and snow
4.5
6.2
21
52
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
5.2
6.2
18
38
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.2
6.1
33
121

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
80
498
2.18
5.65
18.8
8.7
1.4
1.2
inr
0.53
38
137
65
378
2.19
5.39
2.8
2.4
—
—
—
0
0
39
182
2.50
5.37
3.0
2.0
—
—
—
0
0
62
361
2.15
5.08
6.7
4.2
—
—
—
0
0
25
97
2.86
4.91
12.4
4.1
1.2
1.2
mmol/l
0.62
25
85
37
184
2.31
4.38
2.3
1.9
32.1
29.7
s
1.65
37
178
31
145
2.40
4.20
2.0
1.7
—
—
—
0
0
32
158
2.27
3.83
2.4
1.7
—
—
—
0
0
18
70
2.77
3.52
10.1
6.2
24.2
24.3
mmol/l
0.03
18
70
37
209
1.99
3.13
5.9
3.2
0.8
0.8
mmol/l
0.30
37
195
21
94
2.42
3.12
7.9
5.2
0.0
0.2
%
—
9
31
7
12
6.04
3.05
6.6
2.0
—
—
—
0
0
99
763
1.75
3.02
7.1
4.2
6.6
6.6
mmol/l
0.03
94
703
24
116
2.25
3.01
2.5
2.1
302.0
379.0
nmol/l
1.24
24
107
45
276
1.87
2.98
2.1
1.7
1.8
1.2
mg/l
0.64
40
217
22
103
2.31
2.97
7.7
5.0
0.6
1.0
%
—
10
36
20
90
2.39
2.94
7.2
4.9
0.4
0.5
%
—
7
24
32
178
1.99
2.82
2.1
1.7
—
—
—
0
0
20
92
2.34
2.81
8.0
5.2
0.0
0.0
%
—
8
28
23
113
2.20
2.78
18.3
8.1
13.0
9.9
mmol/l
0.86
23
107
78
575
1.68
2.70
21.6
8.9
0.0
0.0
e9/l
0.56
72
464
49
324
1.73
2.50
4.0
3.0
—
—
—
0
0
69
502
1.65
2.46
2.3
2.1
—
—
—
0
0
6
12
5.14
2.42
2.2
1.6
—
—
—
0
0
6
12
5.14
2.42
2.3
1.3
29.8
32.3
pg
—
6
12
8
23
3.60
2.30
4.6
2.8
—
—
—
0
0
8
23
3.60
2.30
9.9
3.0
—
—
—
0
0
73
546
1.61
2.29
3.8
3.4
34.9
50.2
ng/l
0.58
48
368
7
18
4.01
2.28
4.6
1.4
1.4
1.6
mmol/l
—
7
18
40
256
1.74
2.27
3.7
2.7
2.7
3.5
e6/l
0.76
34
232
19
95
2.13
2.21
4.4
3.3
—
—
—
0
0
8
25
3.31
2.12
4.1
2.1
—
—
—
0
0
6
157
0.36
2.02
1.0
1.4
—
—
—
0
0
54
386
1.59
2.00
4.2
3.9
—
—
—
0
0
48
335
1.61
1.95
4.0
3.1
1.0
0.4
e6/l
0.33
38
251
5
11
4.65
1.95
3.0
1.5
—
—
—
0
0
24
138
1.87
1.92
12.6
6.0
5.1
5.0
kpa
0.32
24
131
24
138
1.87
1.92
12.6
6.0
13.0
12.0
kpa
0.25
24
132
26
154
1.82
1.90
1.1
1.3
—
—
—
0
0
7
22
3.28
1.90
1.0
1.2
—
—
—
0
0
8
28
2.95
1.89
8.8
2.6
4.9
4.9
kpa
—
8
28
8
28
2.95
1.89
8.8
2.6
9.0
9.1
kpa
—
8
28
35
230
1.66
1.79
4.3
3.2
732.5
160.9
ng/l
0.47
29
172
13
61
2.23
1.77
11.5
8.2
22.3
24.6
mmol/l
0.96
13
56
37
250
1.62
1.70
3.7
2.8
490.4
578.8
mosm/kgh2o
1.63
31
223
53
390
1.53
1.70
3.0
3.0
7.4
8.1
mmol/l
0.58
41
327
25
152
1.76
1.69
50.9
22.6
2.2
1.4
inr
—
5
23
20
114
1.86
1.65
4.5
4.5
1.3
1.9
mmol/l
0.40
15
82
18
99
1.92
1.65
2.1
1.6
—
—
—
0
0
34
227
1.63
1.64
2.1
1.6
1275.3
1153.0
nmol/l
0.33
28
171
38
261
1.59
1.64
1.7
1.7
513.8
437.4
pmol/l
0.54
33
222
8
33
2.50
1.56
9.6
2.6
7.4
7.4
ph
—
8
28
56
424
1.49
1.55
2.9
2.4
50.1
53.7
u/l
0.45
49
396
5
15
3.40
1.53
5.6
1.4
90.5
91.9
%
—
5
15
54
409
1.48
1.49
3.5
3.4
2.3
2.4
mmol/l
1.26
49
358
6
22
2.79
1.45
1.3
1.4
5127.5
9095.3
e6/l
—
6
16
15
82
1.91
1.41
1.5
2.2
—
—
—
0
0
95
806
1.42
1.41
6.3
4.1
—
356.5
—
0
20
10
47
2.20
1.36
1.2
1.2
—
—
—
0
0
0
40
0.00
1.34
0.0
1.2
—
—
—
0
0
0
40
0.00
1.34
0.0
5.2
—
33.7
—
0
27
16
91
1.84
1.34
12.8
8.2
—
—
—
0
0
47
353
1.46
1.34
9.1
4.3
7.4
7.4
ph
0.04
18
68
17
99
1.80
1.33
3.2
2.9
5.3
4.5
kpa
0.70
17
94
47
354
1.46
1.32
3.0
3.2
105.4
63.8
mg/l
0.34
31
233
10
48
2.15
1.30
13.8
3.6
—
—
—
0
0
8
35
2.35
1.29
1.4
1.2
—
—
—
0
0
49
374
1.44
1.28
3.7
3.9
25.3
8.8
mg/mmol
0.56
32
242
143
1323
1.63
1.28
25.0
13.7
24.7
23.6
mg/l
0.17
128
1043
133
1215
1.50
1.22
5.6
5.6
39.5
39.8
mmol/mol
0.16
125
1134
90
769
1.38
1.21
10.9
9.4
4.9
4.0
e9/l
1.35
83
670
23
151
1.61
1.20
1.7
1.5
—
—
—
0
0
44
335
1.43
1.16
4.0
3.1
—
—
—
0
0
149
1402
1.69
1.11
26.6
12.6
—
—
—
0
0
16
97
1.72
1.11
1.6
2.9
67.5
67.0
g/l
0.09
16
89
5
21
2.42
1.10
1.0
1.1
—
—
—
0
0
66
545
1.35
1.07
5.5
2.5
301.5
121.7
ug/l
0.59
61
504
55
442
1.37
1.06
4.4
3.7
31.8
91.2
e6/l
0.74
45
319
31
225
1.47
1.05
2.5
1.9
—
—
—
0
0
41
314
1.41
1.05
8.9
5.0
—
—
—
0
0
5
22
2.31
1.04
4.6
3.4
64.2
55.0
%
—
5
22
44
342
1.39
1.03
1.9
1.4
—
—
—
0
0
128
1177
1.40
0.98
4.5
4.3
1.9
2.0
mu/l
0.85
115
1077
7
36
1.99
0.98
3.7
2.0
23.6
23.9
mmol/l
—
7
31
14
85
1.71
0.98
5.3
3.3
5.3
5.0
kpa
0.65
14
77
48
383
1.36
0.96
4.3
3.2
17.2
240.5
e6/l
0.74
40
296
100
892
1.31
0.90
4.8
3.7
—
—
—
0
0
79
686
1.29
0.86
8.3
6.1
0.2
0.2
e9/l
0.18
71
610
9
54
1.70
0.76
13.3
8.7
—
—
—
0
0
78
685
1.26
0.75
7.5
5.6
1.8
1.9
e9/l
0.42
71
610
13
84
1.59
0.74
11.5
3.8
—
—
—
0
0
106
967
1.27
0.73
4.2
4.0
12.3
11.2
mm/h
0.34
101
897
62
531
1.27
0.73
7.4
4.6
34.2
35.8
g/l
1.22
57
500
40
324
1.31
0.72
6.5
6.8
—
—
—
0
0
25
190
1.37
0.68
1.3
1.3
293.3
497.9
titre
—
6
47
5
28
1.81
0.66
2.2
2.8
—
—
—
0
0
96
872
1.24
0.66
6.7
4.1
—
—
—
0
0
148
1419
1.44
0.66
25.7
15.6
91.0
80.6
umol/l
1.15
148
1419
10
150
0.65
0.61
1.3
1.4
—
—
—
0
0
50
426
1.25
0.61
8.0
5.1
—
—
—
0
0
11
72
1.57
0.61
3.1
3.1
4.0
4.5
pmol/l
1.53
11
61
74
666
1.20
0.52
7.6
5.6
0.6
0.6
e9/l
0.76
69
580
9
64
1.43
0.52
5.6
4.6
—
—
—
0
0
6
40
1.52
0.52
2.3
1.7
—
—
—
0
0
24
298
0.77
0.51
2.4
2.7
0.7
0.8
ug/l
0.16
15
178
74
668
1.20
0.50
7.6
5.6
0.0
0.0
e9/l
0.65
69
583
134
1284
1.24
0.44
4.5
4.4
6.0
5.9
mmol/l
0.42
121
1179
54
479
1.19
0.44
2.4
2.0
94.0
92.5
pmol/l
0.10
24
249
8
58
1.40
0.42
1.3
1.9
1.5
1.5
g/l
—
8
48
11
79
1.42
0.42
23.4
6.2
25.3
24.1
mmol/l
0.92
11
73
70
638
1.17
0.41
5.4
3.5
0.0
0.0
estimate
0.00
18
119
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
8
61
1.33
0.40
2.0
2.7
1.4
1.3
%
—
8
61
0
18
0.00
0.40
0.0
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
2.8
—
2.4
—
0
19
16
125
1.31
0.38
2.4
2.1
13.4
5.7
ug/l
0.44
16
106
26
217
1.24
0.38
3.7
2.8
2.4
2.5
mmol/l
0.61
19
190
6
43
1.41
0.35
6.0
5.1
—
—
—
0
0
33
286
1.19
0.34
1.3
1.2
0.7
1.3
u/ml
1.13
13
87
56
509
1.15
0.33
4.5
4.5
1.5
2.2
ug/l
1.38
46
457
7
54
1.31
0.31
1.3
1.9
—
—
—
0
0
68
630
1.14
0.30
7.3
4.8
0.0
0.0
estimate
0.00
20
124
101
962
1.13
0.28
4.1
3.6
14.7
14.7
pmol/l
0.04
93
874
9
117
0.76
0.28
1.3
1.5
—
—
—
0
0
8
64
1.26
0.28
5.9
3.4
—
—
—
0
0
42
379
1.15
0.27
5.1
3.2
—
—
—
0
0
9
73
1.25
0.26
1.6
1.2
—
—
—
0
0
25
219
1.17
0.24
1.2
1.2
19.6
37.7
iu/ml
—
8
72
48
520
0.89
0.24
3.0
2.8
—
—
—
0
0
5
37
1.36
0.24
1.8
4.6
93.9
85.4
mg/l
—
5
31
5
37
1.36
0.24
1.8
4.6
69.5
30.6
mg/l
—
5
31
5
38
1.33
0.23
1.4
1.2
—
—
—
0
0
67
630
1.11
0.22
5.5
3.5
0.0
0.0
estimate
0.00
20
122
5
42
1.20
0.21
1.4
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
38
347
1.12
0.21
6.2
3.5
0.0
0.0
estimate
0.50
16
117
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
27
300
0.88
0.20
6.6
3.5
1.0
1.0
kg/l
—
6
41
28
252
1.13
0.19
1.6
1.4
2.3
2.8
g/l
0.68
19
167
12
142
0.83
0.18
1.3
1.3
—
—
—
0
0
15
129
1.18
0.17
2.2
2.2
9.6
14.0
nmol/l
1.41
15
119
10
83
1.22
0.16
1.5
2.5
—
—
—
0
0
137
1345
1.11
0.15
4.9
4.8
2.7
2.8
mmol/l
0.60
128
1236
7
90
0.77
0.15
1.1
1.3
—
—
—
0
0
19
172
1.12
0.12
1.3
1.3
—
—
—
0
0
47
494
0.93
0.12
5.7
3.3
—
—
—
0
0
5
43
1.17
0.10
2.8
3.4
—
—
—
0
0
5
44
1.14
0.10
20.6
11.0
—
—
—
0
0
19
206
0.91
0.09
1.3
1.2
1.0
12.3
u/ml
—
9
83
7
63
1.12
0.08
3.0
2.3
—
—
—
0
0
7
68
1.03
0.08
1.3
1.3
—
—
—
0
0
13
119
1.10
0.06
2.3
2.4
0.2
0.2
g/l
0.12
13
112
123
1220
1.03
0.03
19.3
13.9
39.5
40.5
%
0.46
89
924
26
269
0.96
0.03
5.7
3.3
—
—
—
0
0
15
142
1.06
0.02
1.3
1.3
—
—
—
0
0
131
1318
0.97
0.02
4.8
4.4
4.6
4.6
mmol/l
0.09
123
1219
127
1275
0.98
0.00
4.4
4.0
1.5
1.3
mmol/l
1.05
117
1171
131
1312
0.99
0.00
4.6
4.4
1.4
1.4
mmol/l
0.05
122
1207
12
125
0.96
0.00
6.6
4.7
—
—
—
0
0
10
102
0.98
0.00
3.6
3.5
—
—
—
0
0
12
125
0.96
0.00
2.1
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
1.1
—
0
5
6
63
0.95
0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
7.4
—
38.6
—
0
5
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
9
98
0.91
0.00
1.9
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
3.8
—
10.0
—
0
5
9
95
0.94
0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
8
79
1.01
0.00
2.6
1.4
0.7
1.3
g/l
—
8
69
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ST19_INJURY_BLOOD_VESSE_LOWER_LEG_LEVEL – Injury of blood vessels at lower leg level

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).