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Malignant neoplasm of palate, excluding all cancers (controls excluding all cancers)

C3_PALATE_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C05
  • Hospital discharge: ICD-9 145[2-3]
  • Hospital discharge: ICD-8 1451
  • Cause of death: ICD-10 C05
  • Cause of death: ICD-9 145[2-3]
  • Cause of death: ICD-8 1451
  • Cause of death: excluded ICD-9 145[2-3]
  • Cancer registry: Topography ICD-O-3 C05
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

213

4. Check minimum number of events

None

213

5. Include endpoints

None

213

6. Filter based on genotype QC (FinnGen only)

213

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of palate, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 213 114 99
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 60.76 59.42 62.30

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
77
Matched controls
769
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C05.1
ICD-10 Finland
Malignant neoplasm: Soft palate
+∞
46.7
40
*
130
Kela drug reimbursment
Malignant tumour
+∞
37.6
33
*
EHB00
NOMESCO Finland
Excision of lesion of palate
+∞
33.9
30
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
215.7
28.8
28
*
WF002
NOMESCO Finland
Radical radiotherapy
363.2
26.4
25
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
128.2
25.5
26
*
8070/3-C05.1
ICD-O-3
Squamous cell carcinoma, NOS, of soft palate, NOS
+∞
25.4
23
*
EHA10
NOMESCO Finland
Biopsy of palate
342.2
25.2
24
*
C05.0
ICD-10 Finland
Malignant neoplasm: Hard palate
+∞
24.2
22
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
107.3
22.1
23
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
24.2
17.0
24
14
EP1AE
NOMESCO Finland
Neck ultrasound examination
26.6
16.8
23
12
EEB00
NOMESCO Finland
Partial excision of maxilla
+∞
16.2
15
*
A03FA01
ATC
metoclopramide; systemic, rectal
13.0
15.6
29
34
R4190
NOMESCO Finland
Nutritional therapy
29.4
15.2
20
9
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
183.4
15.0
15
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
7.7
15.0
44
113
GBB00
NOMESCO Finland
Tracheostomy
53.5
14.8
17
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
26.4
14.7
20
10
N02AA05
ATC
oxycodone; systemic
10.3
14.6
31
47
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
+∞
14.0
13
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
14.0
13
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
12.9
12
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
77.0
12.0
13
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
21.3
11.8
17
10
ZX090
NOMESCO Finland
Other technic of radiotherapy
140.1
11.8
12
*
EBA10
NOMESCO Finland
Surgical removal of tooth
12.7
11.7
21
22
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
8.2
11.6
28
50
WX408
NOMESCO Finland
General anesthesy, balanced
6.2
11.5
37
99
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
126.5
10.7
11
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
10.7
10
*
8070/3-C05.9
ICD-O-3
Squamous cell carcinoma, NOS, of palate, NOS
+∞
10.7
10
*
C03.0
ICD-10 Finland
Malignant neoplasm: Upper gum
+∞
10.7
10
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
10.7
10
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
5.1
10.4
51
214
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
30.8
10.2
13
5
SAA03
NOMESCO Finland
Extended examination of mouth
5.0
10.1
46
176
WX110
NOMESCO Finland
Local anesthesy
6.5
9.7
67
391
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
113.4
9.6
10
*
SBB10
NOMESCO Finland
Teeth copy
10.1
9.6
19
24
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
9.6
9
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
42.1
9.3
11
*
Z51.5
ICD-10 Finland
Palliative care
28.0
9.2
12
5
UDQ12
NOMESCO Finland
Flexible laryngoscopy
11.1
9.1
17
19
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
31.6
8.7
11
*
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
31.6
8.7
11
*
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
100.6
8.6
9
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
100.6
8.6
9
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
8.3
8.6
19
29
C05.9
ICD-10 Finland
Malignant neoplasm: Palate, unspecified
+∞
8.5
8
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
8.5
8
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
8.5
8
*
C05.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of palate
+∞
8.5
8
*
WX402
NOMESCO Finland
General anaesthesia
5.7
8.4
26
63
SPF20
NOMESCO Finland
Temporary soling for filling
37.7
8.3
10
*
H02AB02
ATC
dexamethasone; systemic
25.2
8.3
11
5
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
50.3
7.9
9
*
XX3DW
NOMESCO Finland
Time consuming IT work
10.0
7.8
15
18
WX404
NOMESCO Finland
Intravenous generell anesthesy
5.0
7.7
27
75
ZXE10
NOMESCO Finland
More than one and less than three hours
4.0
7.6
40
162
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.9
7.6
27
76
K13.78
ICD-10 Finland
Other change in the oral mucosa
88.2
7.6
8
*
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
88.2
7.6
8
*
ZXE00
NOMESCO Finland
One hour or less
3.9
7.5
43
189
A04AA01
ATC
ondansetron; systemic, rectal
18.0
7.5
11
7
8070/3-C05.0
ICD-O-3
Squamous cell carcinoma, NOS, of hard palate
+∞
7.4
7
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
7.4
7
*
D37.08
ICD-10 Finland
Tumor of uncertain or unknown nature in other part of lip, oral cavity and pharynx
+∞
7.4
7
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
7.4
7
*
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
33.5
7.3
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.8
7.3
46
217
ZXE30
NOMESCO Finland
More than five and less than seven hours
10.9
7.1
13
14
K05.31
ICD-10 Finland
Periodontitis pronounced
6.3
7.1
19
38
A07AA02
ATC
nystatin; oral
7.8
7.1
16
25
JN4BD
NOMESCO Finland
Extensive body CT
10.2
6.9
13
15
A06AD11
ATC
lactulose; oral
5.2
6.8
22
55
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
11.6
6.8
12
12
ZXD10
NOMESCO Finland
Scheduled procedure
3.6
6.8
42
191
SAA04
NOMESCO Finland
Special inverstigation of mouth
8.7
6.8
14
19
ZXA05
NOMESCO Finland
Left side
3.9
6.6
33
125
D10.39
ICD-10 Finland
Benign tumor in other or unspecified part of oral cavity UNS
75.9
6.5
7
*
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
75.9
6.5
7
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
20.1
6.4
9
5
J01DB01
ATC
cefalexin; oral
5.6
6.4
70
493
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
29.3
6.4
8
*
UJC01
NOMESCO Finland
Scopy of lower throat
29.3
6.4
8
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
6.3
6
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
6.3
6
*
ENB00
NOMESCO Finland
Excision or exploration of lesion of pharynx
+∞
6.3
6
*
ZX095
NOMESCO Finland
Combined chemoradiotherapy
+∞
6.3
6
*
C04.1
ICD-10 Finland
Malignant neoplasm: Lateral floor of mouth
+∞
6.3
6
*
ENA10
NOMESCO Finland
Biopsy of pharynx
+∞
6.3
6
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
6.3
6
*
EBA00
NOMESCO Finland
Extraction of tooth
3.5
6.2
37
160
ZXE20
NOMESCO Finland
More than three and less than five hours
4.8
6.1
21
56

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_PALATE_EXALLC – Malignant neoplasm of palate, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).