Follicular adenocarcinoma of thyroid gland, excluding all cancers (controls excluding all cancers)

C3_THYROID_FOLLICULAR_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C73.92&
  • Hospital discharge: ICD-9 193B
  • Cause of death: ICD-10 C73.92&
  • Cause of death: ICD-9 193B
  • Cancer registry: Topography ICD-O-3 C73
  • Cancer registry: Morphology ICD-O-3 833[0-2]|8335
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

364

4. Check minimum number of events

None

364

5. Include endpoints

None

364

6. Filter based on genotype QC (FinnGen only)

364

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Follicular adenocarcinoma of thyroid gland, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 364 240 124
Unadjusted period prevalence (%) 0.07 0.08 0.05
Median age at first event (years) 52.67 49.37 59.05

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
204
Matched controls
2040
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8330/3-C73.9
ICD-O-3
Follicular carcinoma, NOS, of thyroid gland
+∞
268.8
194
*
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
+∞
230.2
175
*
104
Kela drug reimbursment
Thyroid insufficiency
74.2
131.5
156
85
H03AA01
ATC
levothyroxine sodium; systemic
89.4
118.5
193
334
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
125.7
102.6
105
17
EP1AE
NOMESCO Finland
Neck ultrasound examination
57.7
83.7
98
32
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
1096.9
78.9
72
*
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
+∞
75.9
68
*
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
124.9
75.6
78
10
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
+∞
68.7
62
*
BAA60
NOMESCO Finland
Total thyroidectomy
47.6
46.5
56
16
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
56.0
43.8
51
12
JN5AQ
NOMESCO Finland
SPECT of thyroid metastasis with low-dose CT
+∞
37.7
35
*
C73
ICD-10 Finland
Malignant neoplasm of thyroid gland
+∞
34.3
32
*
ZX114
NOMESCO Finland
Intramuscular
47.8
32.6
39
10
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.8
29.9
119
396
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
40.4
27.5
34
10
130
Kela drug reimbursment
Malignant tumour
+∞
24.5
23
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
14.0
24.1
42
37
4CJ01
NOMESCO Finland
NA
+∞
23.4
22
*
C73.99
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland), other or unspecified histology
+∞
23.4
22
*
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
+∞
21.2
20
*
19399
ICD-8 Finland
Malignant neoplasm of thyroid gland
+∞
20.1
19
*
BA1NN
NOMESCO Finland
I-131 dose capsel measurement
+∞
19.1
18
*
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
22.4
16.9
24
12
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
25.7
16.8
23
10
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
14.8
14
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.5
14.1
86
355
WW200
NOMESCO Finland
Immunization
23.1
13.6
19
9
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
26.3
12.7
17
7
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
12.6
12
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
12.6
12
*
1930B
ICD-9 Finland
Malignant neoplasm of thyroid gland[CARCINOMA FOLLICULARE THYREOIDEAE]
+∞
12.6
12
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
19.6
12.3
18
10
WX402
NOMESCO Finland
General anaesthesia
4.5
11.7
44
118
Z51.88
ICD-10 Finland
Other specified medical care
12.9
11.6
20
17
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
11.6
11
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
11.6
11
*
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
+∞
11.6
11
*
H02AB02
ATC
dexamethasone; systemic
26.8
11.3
15
6
XX3DW
NOMESCO Finland
Time consuming IT work
8.4
11.0
24
32
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
10.5
10
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
10.5
10
*
WB223
NOMESCO Finland
Demanding adjuvant hormone therapy of malignancy
+∞
10.5
10
*
8335/3-C73.9
ICD-O-3
Follicular carcinoma, minimally invasive of thyroid gland
+∞
10.5
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.7
9.9
86
429
PJ3AT
NOMESCO Finland
Cytology of lymphnode with ultrasound guidance
93.8
8.5
9
*
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
93.8
8.5
9
*
WF002
NOMESCO Finland
Radical radiotherapy
93.8
8.5
9
*
115
Kela drug reimbursment
Breast cancer
+∞
8.4
8
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
8.4
8
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
8.4
8
*
JN5SN
NOMESCO Finland
NA
+∞
8.4
8
*
106
Kela drug reimbursment
Hypoparathyroidism
46.8
7.8
9
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.0
7.6
49
197
2506
FHL
Thyroidectomy
83.0
7.5
8
*
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
+∞
7.3
7
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
7.3
7
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
7.3
7
*
T71
ICPC
Malignant neoplasm thyroid
+∞
7.3
7
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
12.7
7.2
12
10
NK6AN
NOMESCO Finland
Total body bone isotope imaging
23.4
6.7
9
*
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
72.0
6.5
7
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
6.3
57
278
JN4AD
NOMESCO Finland
Body CT examination
6.7
6.3
15
24
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
6.3
6
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
6.3
6
*
XX9AQ
NOMESCO Finland
Supplementary SPECT-CT or additional scan
+∞
6.3
6
*
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
+∞
6.3
6
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
6.3
6
*
116
Kela drug reimbursment
Prostate cancer
+∞
6.3
6
*

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_THYROID_FOLLICULAR_EXALLC – Follicular adenocarcinoma of thyroid gland, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).