Benign neoplasm: Bladder

CD2_BENIGN_BLADDER

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D30.3&
  • Hospital discharge: ICD-9 2233
  • Hospital discharge: ICD-8 2233
  • Cause of death: ICD-10 D30.3&
  • Cause of death: ICD-9 2233
  • Cause of death: ICD-8 2233

2 out of 7 registries used, show all original rules.

343

4. Check minimum number of events

None

343

5. Include endpoints

None

343

6. Filter based on genotype QC (FinnGen only)

336

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D30
Name in latin
Neoplasma benignum vesicae urinariae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2475 947 1483
Only index persons 1772 757 1015
Unadjusted period prevalence (%)
Whole population 0.04 0.03 0.04
Only index persons 0.03 0.03 0.04
Median age at first event (years)
Whole population 63.13 60.11 64.96
Only index persons 61.04 57.95 63.34

-FinnGen-

Key figures

All Female Male
Number of individuals 336 121 215
Unadjusted period prevalence (%) 0.08 0.04 0.10
Median age at first event (years) 62.76 56.32 66.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
343
Matched controls
3426
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D30.3
ICD-10 Finland
Benign neoplasm: Bladder
+∞
307.7
284
*
KCD02
NOMESCO Finland
Transurethral resection of bladder
41.5
210.7
140
56
UKC02
NOMESCO Finland
Cystoscopy
21.2
174.4
264
467
D41.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bladder
34.7
145.3
98
39
KCD32
NOMESCO Finland
Cystoscopic destruction of tumour of bladder
58.3
87.6
50
10
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
20.1
86.3
71
44
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
17.8
66.3
57
38
8120/3-C67.9
ICD-O-3
Transitional cell carcinoma, NOS, of bladder, NOS
19.0
62.8
52
32
R31
ICD-10 Finland
Unspecified haematuria
6.5
59.9
132
299
UKC05
NOMESCO Finland
Cystoscopy and bladder biopsy
26.4
59.1
42
18
C67.2
ICD-10 Finland
Malignant neoplasm: Lateral wall of bladder
20.5
56.9
45
25
KCD05
NOMESCO Finland
Excision of bladder lesion during urinary tract endoscopy with photodynamic diagnosis (PDD)
19.7
55.8
45
26
2233A
ICD-9 Finland
Benign neoplasm of kidney and other urinary organs, Bladder
+∞
39.3
37
*
1530
FHL
Urethrocystoscopy
9.7
30.3
37
42
22330
ICD-8 Finland
Benign neoplasm of kidney and other urinary organs, Bladder
+∞
29.6
28
*
7323
FHL
Electrosection of TU bladder wall change
101.2
26.1
28
*
D30.0
ICD-10 Finland
Benign neoplasm: Kidney
48.6
22.7
27
6
8120/1-C67.9
ICD-O-3
Urothelial papilloma, NOS, of bladder, NOS
200.3
18.7
19
*
7321
FHL
TU biopsy, coagulation or laser
50.0
16.2
19
*
WX320
NOMESCO Finland
Spinalanesthesy
2.7
15.5
118
563
KCB00
NOMESCO Finland
Biopsy of bladder
47.2
15.2
18
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.0
15.1
46
127
C67.1
ICD-10 Finland
Malignant neoplasm: Dome of bladder
67.2
11.7
13
*
J01EA01
ATC
trimethoprim; systemic
2.3
11.3
110
577
J01MA02
ATC
ciprofloxacin; systemic
2.1
10.3
167
1064
8130/1-C67.9
ICD-O-3
Papillary urothelial neoplasm of low malignant potential of bladder, NOS
41.3
10.0
12
*
KCW96
NOMESCO Finland
Other operations on bladder
20.7
9.9
14
7
C67.4
ICD-10 Finland
Malignant neoplasm: Posterior wall of bladder
56.6
9.7
11
*
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
9.7
54
216
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
9.2
103
566
1888X
ICD-9 Finland
Malignant neoplasm of bladder, Other specified sites of bladder
37.7
9.1
11
*
R33
ICD-10 Finland
Retention of urine
2.5
8.1
56
248
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.1
8.0
22
56
18899
ICD-8 Finland
Malignant neoplasm of bladder
46.0
7.7
9
*
TKC20
NOMESCO Finland
Catheterisation of bladder
2.7
7.7
43
172
KCW02
NOMESCO Finland
Lavation of bladder for coagulated blood
7.4
7.6
17
24
KH1CD
NOMESCO Finland
Very extensive urinary tract ultrasound examination
7.9
7.5
16
21
ZXE00
NOMESCO Finland
One hour or less
1.9
7.4
140
914
C67
ICD-10 Finland
Malignant neoplasm of bladder
20.5
7.2
10
5
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
7.1
66
333
ZX136
NOMESCO Finland
Intravesicalis
10.3
7.1
13
13
C67.0
ICD-10 Finland
Malignant neoplasm: Trigone of bladder
10.3
7.1
13
13
KH1AD
NOMESCO Finland
CT of urinary organs
4.1
7.0
19
48
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.1
7.0
74
394
8130/2-C67.9
ICD-O-3
Papillary urothelial carcinoma, non-invasive of bladder, NOS
9.6
6.8
13
14
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.2
6.8
61
304
KH1BT
NOMESCO Finland
Urinary tract cathetrisation with X-ray guidance
12.6
6.6
11
9
N39.3
ICD-10 Finland
Stress incontinence
3.2
6.5
26
86
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
6.3
110
693
XKD00
NOMESCO Finland
Uroflowmetry
2.0
6.2
84
488
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
4.2
6.1
16
39
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
5.7
6.1
16
29

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
111
150
10.45
82.70
3.9
2.9
—
—
—
0
0
76
328
2.69
11.88
1.4
1.3
—
—
—
0
0
148
873
2.22
11.45
4.6
3.3
—
—
—
0
0
145
873
2.14
10.43
6.8
3.6
99.40
132.07
e6/l
0.15
124
679
112
619
2.20
9.93
4.3
2.7
3.20
4.12
e6/l
0.74
103
557
159
1023
2.03
9.30
2.5
2.2
—
—
—
0
0
243
1825
2.13
9.19
7.5
4.5
—
—
—
0
0
150
999
1.89
7.49
7.5
4.1
57.81
90.86
e6/l
0.85
128
723
233
1792
1.93
7.36
8.8
4.7
3327.17
535.90
e6/l
—
6
30
179
1269
1.86
7.27
5.5
4.0
0.00
0.00
estimate
0.50
35
258
179
1288
1.81
6.76
5.6
4.0
0.00
0.00
estimate
-0.00
33
228
176
1267
1.80
6.58
7.7
5.5
0.00
0.00
estimate
-0.00
33
236
119
763
1.85
6.50
7.0
3.3
—
—
—
0
0
123
799
1.84
6.43
7.1
3.4
0.40
0.55
e6/l
0.25
102
613
82
468
1.99
6.34
6.6
3.1
3.07
1.92
e6/l
0.36
55
265
117
755
1.83
6.22
2.3
2.0
2.61
3.20
mg/l
2.20
98
646
47
219
2.33
6.08
3.9
3.5
—
—
—
0
0
97
605
1.84
5.68
5.2
3.3
548.61
564.54
mosm/kgh2o
0.28
87
515
152
1082
1.72
5.65
3.2
2.7
146.13
148.88
ug/l
0.05
139
988
72
408
1.97
5.64
2.7
2.4
18.23
22.35
%
2.54
62
354
167
1227
1.70
5.48
3.2
2.5
—
—
—
0
0
142
1001
1.71
5.41
5.0
3.8
5.60
5.81
ph
—
5
59
74
430
1.92
5.37
2.6
2.4
2.34
2.29
g/l
0.31
69
393
183
1386
1.68
5.30
7.5
6.7
1.20
1.21
mmol/l
0.76
151
1170
51
261
2.12
5.26
1.8
2.4
63.45
69.99
e9/l
0.97
39
215
78
472
1.84
4.97
2.6
2.3
11.87
12.66
umol/l
0.32
73
435
62
360
1.88
4.47
1.9
2.3
1.62
1.78
%
0.83
51
322
179
1392
1.59
4.35
20.0
16.5
1.38
1.36
inr
0.09
47
405
166
1272
1.59
4.27
5.8
6.0
1.21
1.21
mmol/l
0.47
149
1144
100
688
1.64
3.96
5.2
3.9
—
—
—
0
0
181
1439
1.54
3.81
7.5
6.4
11.12
12.10
umol/l
1.16
175
1358
23
97
2.47
3.73
3.5
2.0
—
—
—
0
0
55
326
1.82
3.71
2.1
1.6
—
—
—
0
0
18
68
2.74
3.61
1.9
4.8
—
—
—
0
0
197
1620
1.50
3.38
5.6
4.8
6.86
6.79
mmol/l
0.20
188
1515
44
251
1.86
3.35
2.1
2.3
173.62
141.54
ug/g
0.14
39
202
13
39
3.42
3.25
1.7
1.5
—
—
—
0
0
182
1492
1.47
3.05
10.9
8.9
4.19
4.34
e9/l
0.38
160
1285
5
5
10.11
2.98
1.0
1.8
—
—
—
0
0
81
567
1.56
2.91
5.2
4.3
1.02
1.02
kg/l
0.33
18
87
7
14
5.07
2.74
1.7
2.4
11.86
16.29
%
—
7
14
7
15
4.73
2.60
1.4
1.3
—
—
—
0
0
27
143
1.96
2.58
6.7
4.8
—
—
—
0
0
46
291
1.67
2.49
4.9
4.0
—
—
—
0
0
39
236
1.73
2.48
1.5
1.4
—
—
—
0
0
35
206
1.78
2.44
5.4
4.6
0.00
0.14
%
2.18
15
72
46
293
1.66
2.43
1.5
1.3
622.86
401.71
titre
0.45
14
70
149
1215
1.40
2.39
8.1
5.6
58.50
58.79
%
0.11
143
1130
145
1177
1.40
2.39
2.6
2.1
95.23
92.38
pmol/l
0.34
70
624
37
223
1.74
2.39
6.0
4.4
1.09
0.91
%
0.14
17
90
11
39
2.88
2.36
1.8
3.5
—
—
—
0
0
113
881
1.42
2.34
6.0
4.3
—
—
—
0
0
114
893
1.41
2.29
4.6
3.8
9.31
11.65
mg/mmol
0.35
74
562
121
960
1.40
2.25
3.7
3.2
1820.86
1695.97
ng/l
0.13
102
827
33
198
1.74
2.17
6.4
4.5
0.04
0.20
%
0.62
13
64
39
246
1.66
2.15
5.1
7.1
1.42
1.35
mmol/l
0.15
39
237
147
1213
1.37
2.13
9.0
5.9
8.49
8.82
%
0.63
141
1124
84
631
1.44
2.11
1.8
1.7
393.02
11004301.87
pmol/l
0.50
66
518
9
31
2.95
2.08
1.3
1.4
—
—
—
0
0
83
624
1.43
2.07
1.7
1.8
1019.46
1167.83
nmol/l
0.92
61
472
110
870
1.39
2.06
3.3
2.4
—
—
—
0
0
278
2552
1.46
2.05
24.6
16.4
23.11
25.79
mg/l
0.78
242
2087
52
357
1.54
2.03
1.3
1.2
—
—
—
0
0
51
349
1.54
2.02
5.6
6.9
0.32
1.13
mmol/l
0.90
40
281
287
2653
1.49
2.02
27.3
19.3
139.78
139.63
mmol/l
0.42
281
2570
47
316
1.56
2.01
1.2
1.3
—
—
—
0
0
9
32
2.86
2.01
1.0
1.4
—
—
—
0
0
32
195
1.70
2.01
2.2
2.9
—
—
—
0
0
33
203
1.69
2.00
5.8
3.2
7.42
7.41
ph
—
5
24
287
2656
1.49
1.98
27.4
19.5
4.00
4.00
mmol/l
0.24
280
2571
7
21
3.38
1.97
1.1
1.1
—
—
—
0
0
145
1206
1.35
1.96
8.4
5.6
2.92
2.84
%
0.12
139
1115
148
1235
1.35
1.96
8.6
5.8
26.87
25.99
%
0.41
142
1145
210
1847
1.35
1.95
4.5
3.7
14.90
14.93
pmol/l
0.05
184
1623
41
269
1.59
1.95
1.3
1.5
—
—
—
0
0
5
11
4.59
1.94
1.0
1.4
6.40
1.14
%
—
5
5
32
197
1.69
1.94
6.1
4.3
0.77
0.54
%
0.24
15
71
95
740
1.39
1.94
3.5
2.9
383.77
9199.22
umol/l
3.92
79
628
106
843
1.37
1.90
3.2
2.4
52.80
61.12
u/l
0.73
101
777
53
373
1.50
1.85
7.5
6.6
105.34
104.28
mmol/l
1.10
53
373
78
592
1.41
1.84
5.2
3.8
—
—
—
0
0
6
17
3.57
1.84
1.2
1.8
39.10
35.32
%
—
6
17
5
12
4.21
1.82
1.2
1.3
79.60
85.80
%
—
5
5
19
102
1.91
1.79
4.2
3.3
0.32
0.29
g/l
—
8
38
105
843
1.35
1.76
3.5
3.2
1281.85
219.47
mg/l
0.64
70
562
146
1232
1.32
1.74
6.5
4.7
34.08
34.89
g/l
1.00
138
1156
13
61
2.17
1.73
1.8
2.6
14.13
15.30
%
—
7
31
90
707
1.37
1.73
5.6
4.2
0.00
0.00
estimate
-0.00
32
229
8
30
2.70
1.73
2.1
2.7
—
—
—
0
0
107
866
1.34
1.70
3.4
3.1
7.12
7.47
mmol/l
0.38
87
703
151
1284
1.31
1.69
7.8
5.4
0.04
0.04
e9/l
0.56
128
1092
12
55
2.22
1.69
1.2
1.7
—
—
—
0
0
13
62
2.14
1.67
2.2
2.2
122.29
125.32
g/l
—
7
44
26
158
1.70
1.67
5.6
8.9
—
—
—
0
0
113
927
1.32
1.63
4.0
3.3
2.36
2.35
mmol/l
0.77
97
803
228
2060
1.31
1.60
10.7
7.7
77.02
79.67
u/l
0.65
223
1904
149
1279
1.29
1.52
7.9
5.3
0.63
0.61
e9/l
0.35
127
1084
34
229
1.54
1.48
7.2
8.7
—
—
—
0
0
136
1159
1.29
1.45
5.1
4.0
39.08
53.17
ng/l
0.87
104
892
60
454
1.39
1.45
1.3
1.3
2.72
2.58
g/l
0.21
37
265
24
149
1.65
1.45
6.7
3.2
—
—
—
0
0
5
16
3.15
1.44
1.0
1.2
—
—
—
0
0
6
22
2.75
1.44
1.7
1.2
—
—
—
0
0
214
1932
1.28
1.43
5.9
4.1
15.25
13.48
mm/h
0.69
199
1745
151
1307
1.28
1.42
7.9
5.5
1.83
1.88
e9/l
0.20
130
1148
138
1182
1.28
1.41
9.7
6.2
—
—
—
0
0
153
1328
1.27
1.40
8.1
5.6
0.21
0.20
e9/l
0.33
132
1152
255
2367
1.30
1.30
7.6
6.5
41.73
40.88
mmol/mol
0.68
237
2158
10
48
2.11
1.28
2.2
3.0
—
—
—
0
0
9
44
2.07
1.27
1.3
1.8
63.44
60.83
%
—
9
44
101
842
1.28
1.26
6.2
4.2
—
—
—
0
0
99
824
1.28
1.25
3.2
4.3
7.41
7.40
ph
0.26
22
160
136
1178
1.25
1.23
8.7
5.6
0.65
0.62
%
0.36
130
1085
8
38
2.13
1.19
1.5
1.5
—
—
—
0
0
6
26
2.33
1.19
1.0
1.1
—
—
—
0
0
118
1012
1.25
1.16
2.8
2.3
76.08
76.44
nmol/l
0.04
105
873
5
20
2.52
1.15
1.4
1.4
—
—
—
0
0
88
729
1.28
1.15
1.9
1.6
21.17
19.89
nmol/l
0.31
73
601
53
409
1.35
1.15
2.3
1.9
—
—
—
0
0
248
2308
1.26
1.15
5.7
4.5
2.09
1.97
mu/l
0.43
226
2038
71
572
1.30
1.15
5.4
3.8
225.69
222.17
ng/l
0.01
62
476
173
1549
1.23
1.14
4.6
3.2
58.91
54.25
u/l
0.26
163
1419
26
176
1.51
1.13
4.7
3.1
—
—
—
0
0
33
235
1.45
1.13
1.5
1.6
—
—
—
0
0
31
219
1.45
1.11
6.4
3.9
—
—
—
0
0
7
31
2.28
1.11
1.6
1.2
—
—
—
0
0
290
2757
1.33
1.10
35.7
24.0
239.01
238.83
e9/l
0.01
284
2672
290
2758
1.33
1.09
35.6
24.0
4.38
4.44
e12/l
0.98
284
2658
290
2758
1.33
1.09
35.7
24.1
39.79
39.64
%
0.17
266
2563
290
2759
1.32
1.08
35.7
23.9
6.89
6.86
e9/l
0.08
284
2663
61
490
1.30
1.01
1.3
1.2
0.55
1.65
u/ml
1.47
14
126
32
232
1.42
1.01
2.5
2.0
375.48
381.90
nmol/l
0.06
27
212
7
35
2.02
1.00
2.9
1.6
13.16
16.58
ug/l
—
7
35
5
23
2.19
0.98
2.8
2.7
—
—
—
0
0
19
125
1.55
0.95
1.4
1.3
—
—
—
0
0
11
62
1.80
0.95
2.3
2.3
—
—
—
0
0
7
37
1.91
0.94
1.4
2.0
32.57
32.32
pg
—
7
37
10
55
1.84
0.92
1.9
2.3
—
—
—
0
0
15
94
1.62
0.91
6.5
5.5
—
—
—
0
0
143
1279
1.20
0.90
6.0
5.5
2.23
3.05
ug/l
1.14
129
1129
250
2355
1.22
0.89
4.6
4.3
1.39
1.26
mmol/l
1.82
222
2114
8
42
1.92
0.89
1.1
1.2
—
—
—
0
0
8
42
1.92
0.89
1.5
2.1
—
—
—
0
0
8
43
1.88
0.88
1.4
1.4
—
—
—
0
0
8
43
1.88
0.88
2.6
3.1
3.49
4.66
e9/l
—
8
43
6
30
2.01
0.87
1.3
1.4
—
—
—
0
0
78
659
1.24
0.87
7.2
6.8
—
—
—
0
0
8
45
1.79
0.84
3.3
3.7
53.00
58.80
%
—
8
45
6
31
1.95
0.84
1.0
1.0
—
—
—
0
0
10
57
1.77
0.84
4.1
3.1
—
—
—
0
0
10
57
1.77
0.84
6.7
2.4
—
—
—
0
0
45
358
1.29
0.82
1.4
1.3
34.70
12.91
u/ml
0.47
20
124
6
32
1.89
0.82
1.2
1.0
—
—
—
0
0
8
47
1.72
0.81
3.8
3.1
—
—
—
0
0
7
122
0.56
0.79
1.1
1.5
—
—
—
0
0
0
25
0.00
0.79
0.0
1.1
—
3.97
—
0
11
0
25
0.00
0.79
0.0
1.1
—
0.94
—
0
10
41
328
1.28
0.73
3.7
4.4
3.96
45.98
ug/l
1.10
33
281
5
25
2.01
0.73
1.4
1.4
—
—
—
0
0
272
2606
1.21
0.70
24.4
15.4
—
—
—
0
0
12
179
0.66
0.68
1.8
1.4
—
—
—
0
0
258
2462
1.19
0.68
5.1
4.8
4.38
4.44
mmol/l
0.37
230
2240
67
573
1.21
0.67
1.8
1.7
1.00
1.44
mg/l
1.53
52
450
7
43
1.64
0.67
1.1
1.1
—
—
—
0
0
5
28
1.79
0.66
1.0
1.3
—
—
—
0
0
5
28
1.79
0.66
1.4
1.4
—
—
—
0
0
11
70
1.59
0.65
2.8
4.0
7.40
7.42
ph
1.05
11
64
277
2664
1.20
0.65
14.6
11.1
25.25
25.21
u/l
0.02
266
2546
46
380
1.24
0.64
1.2
1.3
21.84
37.16
iu/ml
1.20
16
128
11
71
1.57
0.62
1.1
1.2
—
3.35
—
0
8
255
2439
1.17
0.62
5.2
4.7
1.37
1.43
mmol/l
1.50
227
2201
34
273
1.27
0.60
2.5
2.5
5.45
8.56
ug/l
0.83
26
239
0
21
0.00
0.60
0.0
3.0
—
7.42
—
0
5
19
140
1.38
0.59
2.8
2.5
—
—
—
0
0
125
1140
1.15
0.58
16.0
10.2
0.00
0.00
e9/l
0.59
102
918
6
36
1.68
0.57
1.2
1.9
88.58
88.63
%
—
6
36
6
36
1.68
0.57
1.0
1.1
—
—
—
0
0
262
2518
1.17
0.56
5.5
5.4
2.56
2.59
mmol/l
0.25
233
2269
257
2467
1.16
0.56
5.8
5.0
6.30
6.08
mmol/l
1.70
232
2217
22
170
1.31
0.52
1.2
1.2
—
—
—
0
0
6
40
1.51
0.52
1.2
1.4
—
—
—
0
0
83
745
1.15
0.48
3.4
3.2
—
—
—
0
0
7
50
1.41
0.45
1.3
1.1
—
—
—
0
0
75
673
1.14
0.44
1.8
1.7
1.37
1.31
mmol/l
0.34
68
549
18
139
1.31
0.44
1.1
1.2
—
—
—
0
0
192
1825
1.12
0.44
4.4
4.2
—
—
—
0
0
72
645
1.15
0.44
1.4
1.4
—
—
—
0
0
5
32
1.57
0.42
2.8
2.7
—
—
—
0
0
36
306
1.20
0.41
1.2
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
5
34
1.48
0.40
1.2
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
2.0
—
9.16
—
0
18
5
35
1.43
0.39
2.4
2.6
—
—
—
0
0
5
35
1.43
0.39
1.2
1.1
—
—
—
0
0
9
68
1.33
0.38
1.1
1.7
—
—
—
0
0
37
320
1.17
0.36
1.3
1.7
—
—
—
0
0
6
86
0.69
0.33
1.2
1.2
—
—
—
0
0
7
55
1.28
0.30
1.1
1.2
—
—
—
0
0
28
242
1.17
0.28
1.3
1.5
—
—
—
0
0
11
139
0.78
0.27
1.3
1.3
—
45.81
—
0
8
10
77
1.31
0.26
1.6
1.6
—
—
—
0
0
20
169
1.19
0.26
3.0
2.6
3.73
6.15
e9/l
0.80
12
127
11
87
1.27
0.24
4.5
3.5
—
—
—
0
0
16
134
1.20
0.23
1.4
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
184.20
—
0
5
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
168.15
—
0
11
0
11
0.00
0.21
0.0
5.1
—
50.59
—
0
11
0
14
0.00
0.20
0.0
1.2
—
156.38
—
0
14
69
732
0.93
0.19
4.2
3.2
0.76
0.81
ug/l
0.17
53
523
52
557
0.92
0.19
4.3
3.3
2.49
2.45
mmol/l
1.37
44
489
11
128
0.85
0.14
3.4
3.1
11.09
2296.26
u/ml
1.01
11
111
15
132
1.14
0.13
1.3
1.5
—
—
—
0
0
11
95
1.16
0.11
2.4
3.2
38.49
37.51
g/l
0.24
11
82
9
88
1.02
0.07
7.9
11.2
—
—
—
0
0
23
218
1.06
0.05
4.3
4.0
—
—
—
0
0
12
129
0.93
0.04
1.2
1.3
—
—
—
0
0
22
223
0.98
0.00
1.6
1.4
—
—
—
0
0
11
108
1.02
0.00
6.1
5.0
—
—
—
0
0
15
148
1.01
0.00
1.3
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
7
72
0.97
0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
51.00
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
88
0.91
-0.00
2.3
2.0
20.63
22.00
s
—
8
81
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
37825.63
—
0
8
0
8
0.00
-0.00
0.0
1.3
—
1.17
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
-0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
23.0
—
1211.71
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
40.14
—
0
7
0
7
0.00
-0.00
0.0
24.7
—
2558.43
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
14556.60
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_BLADDER and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_BLADDER 1.365 [1.11, 1.68] 0.004
Birth year 0.991 [0.98, 1.0] 0.048

During the follow-up period (1.1.1998 — 31.12.2019), 171 out of 564 females with CD2_BENIGN_BLADDER died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_BLADDER 1.415 [1.17, 1.7] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 343 out of 846 males with CD2_BENIGN_BLADDER died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_BLADDER.

N-year risk Females Males
1 0.114% 0.309%
5 0.766% 1.871%
10 1.776% 4.391%
15 3.311% 8.048%
20 5.832% 13.67%

Relationships between endpoints

Index endpoint: CD2_BENIGN_BLADDER – Benign neoplasm: Bladder

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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