Benign neoplasm: Heart

CD2_BENIGN_HEART

Vaginal neoplasm: Tumors or cancer of the VAGINA.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D15.1& Hospital discharge: ICD-9 — 2127 Cause of death: ICD-10 — D15.1& Cause of death: ICD-9 — 2127 2 out of 7 registries used, show all original rules.	118
4. Check minimum number of events None	118
5. Include endpoints None	118
6. Filter based on genotype QC (FinnGen only)	118

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D15
Name in latin: Neoplasma benignum cordis

NAME	CD2_BENIGN_HEART
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D151
HD_ICD_9	2127
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D151
COD_ICD_9	2127
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Heart based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Benign neoplasm: Heart

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	719	436	281
Only index persons	621	389	232
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	61.80	64.15	58.30
Only index persons	63.25	64.79	60.65

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	118	72	46
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	61.96	61.07	63.36

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
106: Matched controls
1060

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D15.1

ICD-10 Finland

Benign neoplasm: Heart

+∞

147.1

104

FFA10

NOMESCO Finland

Excision of lesion of atrium

+∞

73.8

FM1BE

NOMESCO Finland

Cardiac ultrasound examination through oesophagus

31.7

38.1

FXA00

NOMESCO Finland

Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure

61.8

36.9

WX872

NOMESCO Finland

Intensive care

16.0

19.8

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

6.7

17.5

151

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

7.8

17.5

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

7.1

16.0

AJX

Other surgery on the heart or aorta

+∞

13.8

B01AA03

ATC

warfarin; systemic

5.0

11.4

127

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

4.6

11.3

167

D48.7

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Other specified sites

31.8

11.0

AMX

Other surgical procedure for a demanding cardiac patient

+∞

10.6

C07AB07

ATC

bisoprolol; oral

3.5

8.5

370

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.4

8.5

363

I48

ICD-10 Finland

Atrial fibrillation and flutter

3.7

8.0

154

I34.00

ICD-10 Finland

Mitral (valve) incompetence NOS or of specified cause, except rheumatic

27.3

7.7

WX408

NOMESCO Finland

General anesthesy, balanced

3.4

7.5

189

Other heart surgery

+∞

7.4

C03CA01

ATC

furosemide; systemic

3.3

7.3

207

290

Kela drug reimbursment

Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation

4.1

7.3

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

5.9

6.9

B01AB05

ATC

enoxaparin; parenteral

3.1

6.8

231

D15.9

ICD-10 Finland

Benign neoplasm: Intrathoracic organ, unspecified

+∞

6.3

207

Kela drug reimbursment

Chronic arrhythmias

3.8

6.2

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3032080) INR in Blood by Coagulation assay

423

5.49

15.94

11.8

8.1

1.3

inr

0.10

129

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

7.47

10.96

5.2

2.2

0.4

0.5

u/ml

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

229

3.27

8.93

2.1

2.2

—

(3044640) Blood type and Crossmatch panel - Blood

309

3.12

8.53

2.3

2.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

456

3.22

8.33

4.1

3.8

—

(3002256) Pathology report gross observation

118

3.35

7.16

1.3

—

(3023368) Bacteria identified in Blood by Culture

274

2.70

6.39

5.7

4.2

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

126

2.85

5.27

14.4

6.4

5.4

5.1

kpa

0.57

119

(3027801) Oxygen [Partial pressure] in Arterial blood

126

2.85

5.27

14.4

6.4

13.5

11.6

kpa

0.84

119

(3016502) Oxygen saturation in Arterial blood

114

2.91

5.19

15.0

6.7

94.9

95.7

0.14

109

(3013826) Glucose [Moles/volume] in Serum or Plasma

609

2.63

5.16

9.7

4.5

6.8

6.7

mmol/l

0.12

567

(3003396) Base excess in Arterial blood by calculation

128

2.80

5.11

14.4

6.4

2.0

1.5

mmol/l

0.20

(3002173) Hemoglobin [Mass/volume] in Arterial blood

103

2.96

5.06

15.0

7.0

112.1

121.4

g/l

1.56

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

244

2.45

5.04

3.6

2.0

2.9

3.1

mg/l

0.20

211

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

507

2.23

4.23

9.5

6.9

1.2

mmol/l

2.00

431

(3018418) pH of Serum or Plasma

304

2.19

4.10

4.0

4.2

7.4

—

(4035726)

2.82

3.98

1.2

1.4

—

(3022217) INR in Platelet poor plasma by Coagulation assay

132

2.47

3.85

41.0

22.8

1.6

1.4

inr

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

472

2.11

3.81

12.9

6.0

1.2

mmol/l

2.25

423

(3014007) Fractional oxyhemoglobin in Arterial blood

3.04

3.78

17.5

8.5

95.6

94.5

1.23

(3001122) Ferritin [Mass/volume] in Serum or Plasma

404

2.06

3.62

3.9

2.7

98.3

117.8

ug/l

0.46

369

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

4.11

3.60

6.6

3.5

89.2

98.6

—

(3019060) Gas panel - Arterial blood

2.79

3.59

9.8

4.4

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.03

3.59

7.8

3.1

127.2

127.7

g/l

0.03

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

406

1.97

3.25

6.4

4.1

73.9

33.0

ng/l

1.20

294

(40760888) Immunoglobulin light chains.free panel - Serum

4.96

2.97

1.5

8.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.69

2.93

2.6

1.3

—

(3006504) Eosinophils/100 leukocytes in Blood

464

1.89

2.90

6.9

5.6

2.9

2.7

0.37

431

(3013650) Neutrophils [#/volume] in Blood by Automated count

573

1.92

2.84

11.6

10.0

4.2

e9/l

0.11

493

(3024928) Oxygen saturation in Venous blood

3.97

2.73

4.7

3.0

—

(3019230) Fractional oxyhemoglobin in Venous blood

4.58

2.51

2.3

71.6

60.7

—

(3000991) Gas panel - Venous blood

2.25

2.49

16.0

7.4

—

(3013115) Eosinophils [#/volume] in Blood

511

1.78

2.41

6.7

5.9

0.2

e9/l

0.50

442

(3013707) Erythrocyte sedimentation rate by Westergren method

751

1.93

2.32

4.9

4.1

21.0

12.4

mm/h

2.63

682

(42870588) Differential panel, method unspecified - Blood

338

1.77

2.31

7.5

5.5

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.47

2.24

23.4

6.4

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

314

1.76

2.23

3.2

3.0

27.3

30.0

u/l

0.66

304

(3012544) pH of Venous blood

110

2.11

2.23

7.7

4.1

—

(3044889) 12 lead EKG panel

697

1.78

2.09

6.0

3.8

—

(3001604) Monocytes [#/volume] in Blood

496

1.69

2.07

6.7

5.7

0.6

e9/l

0.08

420

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

103

899

2.15

2.06

4.9

4.8

1.9

2.0

mu/l

0.20

808

(3019198) Lymphocytes [#/volume] in Blood

506

1.69

2.06

6.7

5.7

1.8

2.2

e9/l

0.82

442

(3006315) Basophils [#/volume] in Blood

497

1.69

2.05

6.7

5.7

0.0

e9/l

0.08

423

(3026008) Bacteria identified in Urine by Culture

313

1.71

2.01

4.9

3.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

106

939

2.27

1.98

4.8

6.0

mmol/l

0.05

849

(3037522) Nuclear Ab [Titer] in Serum

117

1.97

1.90

1.8

1.4

360.0

543.7

titre

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.24

1.84

1.4

2.4

—

(3043409) Potassium [Moles/volume] in Arterial blood

2.70

1.84

8.2

4.2

4.1

3.9

mmol/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

174

1.80

1.83

3.4

1.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

119

1.93

1.81

3.1

1.7

—

(3030467) Casts [#/volume] in Urine by Automated count

286

1.66

1.78

4.0

3.0

0.8

0.6

e6/l

0.17

208

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

368

1.62

1.76

4.3

3.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

168

1.79

1.75

3.1

2.7

1.9

1.1

e6/l

0.50

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

121

1.89

1.72

3.2

1.8

—

(3003694) ABO and Rh group [Type] in Blood

236

1.69

1.72

1.4

1.3

—

(40758558) Short blood count panel - Blood

246

1.67

1.68

6.9

8.1

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

554

1.59

1.66

7.0

6.2

10.3

11.3

umol/l

0.65

521

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.68

1.63

1.2

1.3

—

(36304419) Bacteria [Presence] in Urine

275

1.62

1.61

4.1

2.8

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.10

1.60

1.0

1.5

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.10

1.60

1.0

1.5

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.39

1.58

7.9

3.3

28.3

24.3

mmol/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.39

1.58

1.3

2.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

671

1.60

1.55

5.2

4.4

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

443

1.55

5.5

4.2

34.4

35.2

g/l

0.44

416

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

406

1.55

1.53

2.1

1.9

101.4

95.1

pmol/l

0.39

195

(3013512) EKG study

296

1.59

1.53

7.1

4.3

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.95

1.52

1.5

1.1

—

(3031040) Bacteria [#/volume] in Urine by Automated count

652

1.58

1.52

6.1

4.6

—

64.4

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.82

1.45

2.7

1.3

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

336

1.55

1.44

4.1

3.1

2.3

2.4

mmol/l

0.09

291

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

627

1.54

1.41

3.4

3.2

43.4

50.3

u/l

0.65

584

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.50

1.41

2.9

1.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

162

1.69

1.41

3.2

2.9

2.1

2.9

e6/l

0.32

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.69

1.38

1.7

1.9

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

107

979

2.00

1.37

25.8

14.6

27.7

22.7

mg/l

0.93

768

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

559

1.51

1.37

2.9

2.8

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

745

1.57

1.34

3.4

4.0

15.0

14.8

pmol/l

0.34

669

(40768804) Tissue Pathology biopsy report

387

1.51

1.34

2.1

2.2

—

(40768797) Stomach Pathology biopsy report

140

1.70

1.32

1.4

1.3

—

(3023520) Reticulocytes [#/volume] in Blood

1.83

1.29

2.6

75.6

69.3

e9/l

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.70

1.23

1.0

1.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.38

1.20

1.3

—

(3020891) Body temperature

2.13

1.18

15.8

4.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

100

908

1.66

1.17

5.7

6.1

39.3

40.7

mmol/mol

0.95

838

(1002224) Polysomnography panel

2.44

1.10

1.0

1.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.44

1.10

1.8

1.9

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

173

1.56

1.09

1.1

1.2

148.8

36.7

iu/ml

—

(3002582) Erythrocytes [#/volume] in Urine

317

1.45

1.07

4.1

3.1

40.0

30.0

e6/l

0.23

237

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.03

1.06

8.0

2.7

0.7

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

124

1.63

1.05

2.3

4.2

3.7

40.4

ug/l

0.58

107

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.12

1.05

1.4

1.5

—

(3018095) Leukocytes [#/volume] in Urine

365

1.43

1.04

4.7

3.6

49.6

78.7

e6/l

0.40

254

(3000492) Spirometry study

1.80

1.04

1.4

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

100

1.69

1.03

4.5

3.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

211

1.50

1.02

1.6

1.4

3.3

2.4

g/l

0.77

113

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.90

1.01

8.0

2.6

1.1

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

229

1.48

1.01

4.2

3.8

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

109

1027

1.80

0.97

29.2

17.4

77.2

77.5

umol/l

0.04

109

1027

(40768443) Skin Pathology biopsy report

1.95

0.95

1.7

1.2

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

179

1.50

0.94

3.1

2.6

2.5

mmol/l

0.63

155

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

162

1.52

0.93

1.2

22.7

9.0

u/ml

—

(3026782) Osmolality of Urine

197

1.48

0.93

3.6

2.8

542.5

529.4

mosm/kgh2o

0.12

166

(3021589) Normoblasts [#/volume] in Blood

438

1.38

0.93

13.6

10.0

0.0

e9/l

0.91

347

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.69

0.92

1.6

—

(4010399)

1.76

0.85

1.3

1.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.98

0.85

1.5

2.0

—

(3042936) Bacteria identified in Isolate by Culture

141

1.50

0.81

1.7

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

107

1010

1.64

0.78

32.3

17.1

4.0

mmol/l

0.11

107

984

(4034850)

1.80

0.77

16.2

14.3

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.22

0.77

1.6

1.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

910

1.45

0.76

4.3

4.1

1.2

1.3

mmol/l

0.99

821

(1616796) Gas panel - Central venous blood

2.13

0.75

7.8

2.8

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

2.04

0.73

3.0

1.5

—

2.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.04

0.73

1.0

1.4

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

2.04

0.73

3.0

1.5

—

2.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.04

0.73

1.4

1.5

—

(4094501)

1.89

0.69

1.0

1.1

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

904

1.41

0.69

21.4

14.0

79.2

77.7

ml/min/173m2

0.31

734

(3008898) HLA-B27 [Presence]

1.76

0.64

1.0

1.1

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.64

0.64

4.7

25.5

24.3

mmol/l

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

102

962

1.44

0.64

5.6

5.2

2.6

2.7

mmol/l

0.72

874

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

100

941

1.41

0.62

4.8

4.6

1.4

1.5

mmol/l

1.75

856

(3022313) Gas panel - Capillary blood

1.61

0.62

6.1

5.0

—

(40761511) CBC panel - Blood by Automated count

106

1008

1.51

0.62

24.1

14.0

—

(1761868) Lipid panel - Serum or Plasma

324

0.75

0.61

3.4

3.0

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.59

0.0

1.1

—

12.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.56

0.58

1.5

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.59

0.57

2.6

1.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

267

0.74

0.56

5.4

3.4

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

198

1.33

0.55

1.5

1.9

371.6

488.1

pmol/l

1.82

161

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

119

1.40

0.51

6.9

8.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

201

1.31

0.50

5.1

5.5

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

100

950

1.35

0.49

4.8

4.6

4.4

4.6

mmol/l

1.45

875

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.55

0.49

10.9

3.7

43.5

45.7

—

(3000330) Specific gravity of Urine by Test strip

1.52

0.48

3.4

4.8

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.59

0.43

1.6

2.1

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

397

1.22

0.42

3.0

2.3

73.0

78.0

nmol/l

0.63

343

(46235355) HIV 1 and 2 tests - Meaningful Use set

142

1.32

0.41

1.2

1.7

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.41

0.0

1.3

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.41

0.0

1.3

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.41

0.0

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.49

0.41

1.0

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.45

0.40

1.0

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.45

0.40

1.0

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

286

0.80

0.39

6.6

4.0

0.0

estimate

0.00

(40768800) Prostate Pathology biopsy report

0.00

0.39

0.0

1.2

—

(3049717) Cytology report of Urine Cyto stain

1.45

0.36

1.5

3.6

—

(3009261) Glucose [Presence] in Urine by Test strip

482

1.18

0.35

4.8

3.9

0.0

estimate

0.00

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

375

0.83

0.34

5.9

4.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.32

0.33

1.0

1.3

—

(36660697) Celiac disease serology panel - Serum

1.34

0.33

1.0

1.2

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.36

0.31

4.1

4.8

1.2

mmol/l

—

(3009542) Hematocrit [Volume Fraction] of Blood

871

1.20

0.30

29.0

15.1

39.2

39.7

0.32

602

(3007853) Bacteria identified in Skin by Aerobe culture

103

1.29

0.29

2.1

1.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.23

0.27

1.0

1.4

—

(3035350) Ketones [Presence] in Urine by Test strip

474

1.13

0.23

4.8

3.9

0.0

estimate

0.00

(3000963) Hemoglobin [Mass/volume] in Blood

110

1078

1.30

0.22

38.0

21.6

127.6

134.1

g/l

4.70

110

1060

(3024731) MCV [Entitic volume]

110

1078

1.30

0.22

37.3

21.5

90.9

91.1

0.25

110

1062

(3010813) Leukocytes [#/volume] in Blood

110

1078

1.30

0.22

37.5

21.6

6.9

6.8

e9/l

0.31

110

1043

(3035941) MCH [Entitic mass]

110

1078

1.30

0.22

37.3

21.4

29.9

30.3

1.32

110

1062

(3007461) Platelets [#/volume] in Blood

110

1078

1.30

0.22

37.4

21.5

258.1

249.8

e9/l

0.55

110

1049

(3026361) Erythrocytes [#/volume] in Blood

110

1078

1.30

0.22

37.4

21.6

4.3

4.5

e12/l

1.68

110

1041

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.20

0.22

1.0

2.2

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.20

0.22

1.0

1.8

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

1.8

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(4281824)

0.00

0.21

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

3.8

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.21

0.0

1.9

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.2

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.21

0.0

1.1

—

(3017354) Segmented neutrophils/100 leukocytes in Blood

0.00

0.21

0.0

2.0

—

52.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

144

0.81

0.21

1.6

1.5

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.29

0.21

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.20

0.0

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

478

1.12

0.20

6.3

5.1

0.0

estimate

0.00

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.19

0.19

1.0

2.1

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

128

1.20

0.19

4.6

35.3

32.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.71

0.17

1.2

1.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

236

1.13

0.16

1.7

1.3

1.4

u/ml

—

(21494755) Public health laboratory ask at order entry panel

0.79

0.16

1.0

1.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.15

0.15

1.4

1.7

—

(3015736) pH of Urine

366

1.10

0.14

3.9

3.7

—

(3019309) Folate [Moles/volume] in Red Blood Cells

193

1.11

0.10

1.8

1.7

1008.7

1231.9

nmol/l

0.61

149

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

236

0.92

0.09

3.7

4.5

29.1

21.8

—

116

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.10

0.09

1.2

1.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

313

1.08

0.09

3.2

3.9

16.7

10.1

mg/mmol

0.21

193

(3017732) Neutrophils [#/volume] in Blood

1.06

0.08

1.3

2.0

5.9

3.5

e9/l

—

(3048689) Calprotectin [Mass/mass] in Stool

122

0.89

0.07

2.4

2.1

119.2

171.4

ug/g

0.44

(40761536) Microorganisms panel - Urine sediment

1.08

0.07

8.1

3.6

—

(40761535) Cells panel - Urine sediment

1.05

0.07

6.0

4.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

142

0.91

0.07

1.6

1.5

—

(3022145) Colonoscopy Study observation

110

1.10

0.05

1.7

1.3

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

298

1.05

0.05

4.7

5.2

2.2

2.1

ug/l

0.03

260

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

329

1.05

0.04

2.6

2.3

49.4

54.3

u/l

0.65

300

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

271

1.04

0.03

1.6

1.7

1.3

mmol/l

0.16

226

(3012516) Albumin [Mass/volume] in Urine

292

1.04

0.02

2.6

3.2

2004.4

275.6

mg/l

0.40

190

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

176

0.96

0.00

3.1

3.0

2.2

0.7

ug/l

0.71

121

(3000494) Fungus identified in Specimen by Culture

121

0.99

0.00

1.2

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

122

0.98

0.00

1.2

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

108

1.02

0.00

1.1

1.5

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

1.8

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3035457) Cefaclor IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.6

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.6

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

30.2

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(42868499) Enterovirus IgG Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.4

—

(3022621) pH of Urine by Test strip

0.99

0.00

4.6

2.6

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.4

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.5

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

5.9

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.7

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

4.8

—

42.2

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3019225) pH of Specimen

0.90

0.00

2.6

4.9

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

2.9

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.3

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

2.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.3

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.4

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

2.2

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1720.2

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

3.2

—

3.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.4

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

8.6

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.5

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

3.2

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.3

—

(4027681)

0.00

0.0

1.1

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.3

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3025941) Bacteria identified in Stool by Culture

0.93

0.00

1.0

1.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.9

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.4

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.1

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.98

0.00

1.0

1.3

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

11.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.87

0.00

1.0

2.3

—

(3004451) EKG impression Narrative

0.00

0.0

1.5

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_HEART and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_HEART	1.784 [1.25, 2.54]	0.001
Birth year	0.995 [0.99, 1.0]	0.247

During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 322 females with CD2_BENIGN_HEART died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_HEART.

N-year risk	Females	Males
1	0.171%	No data
5	1.002%	No data
10	2.657%	No data
15	5.205%	No data
20	9.086%	No data

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_HEART – Benign neoplasm: Heart

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Heart

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints