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Benign neoplasm: Heart

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_HEART

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D15.1&
  • Hospital discharge: ICD-9 — 2127
  • Cause of death: ICD-10 — D15.1&
  • Cause of death: ICD-9 — 2127

2 out of 7 registries used, show all original rules.

122

4. Check minimum number of events

None

122

5. Include endpoints

None

122

6. Filter based on genotype QC (FinnGen only)

114

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D15
Name in latin
Neoplasma benignum cordis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 719 436 281
Only index persons 621 389 232
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 61.80 64.15 58.30
Only index persons 63.25 64.79 60.65

-FinnGen-

Key figures

All Female Male
Number of individuals 114 68 46
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 63.64 63.83 63.36

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
122
Matched controls
1220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D15.1
ICD-10 Finland
Benign neoplasm: Heart
+∞
170.3
120
*
FFA10
NOMESCO Finland
Excision of lesion of atrium
+∞
81.7
69
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
32.1
79.4
62
38
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
42.4
74.3
49
19
WX872
NOMESCO Finland
Intensive care
19.3
43.8
39
29
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.0
25.1
56
132
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
6.5
24.3
67
192
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
6.2
22.0
56
147
B01AA03
ATC
warfarin; systemic
5.1
17.0
51
150
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.4
15.1
62
230
D48.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other specified sites
84.5
13.9
15
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.0
13.6
23
39
AJX
HP
Other surgery on the heart or aorta
144.2
12.7
13
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.2
12.5
85
434
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
4.0
11.1
41
136
AMX
HP
Other surgical procedure for a demanding cardiac patient
+∞
10.6
10
*
C07AB07
ATC
bisoprolol; oral
3.5
9.7
84
472
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
5.4
9.2
20
43
C03CA01
ATC
furosemide; systemic
3.2
9.2
59
275
B01AF02
ATC
apixaban; oral
4.0
9.1
30
91
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.3
9.0
46
187
B01AB05
ATC
enoxaparin; parenteral
3.0
8.1
59
291
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
4.1
7.9
24
68
207
Kela drug reimbursment
Chronic arrhythmias
3.4
7.8
35
130
R06.0
ICD-10 Finland
Dyspnoea
3.0
7.6
48
217
51
HP
Other heart surgery
+∞
7.4
7
*
XF404
NOMESCO Finland
Ambulatory ECG
4.1
7.3
22
62
AN1
HP
Coronary angiography
3.7
7.1
26
84
TFP20
NOMESCO Finland
Cardiodefibrillation
4.2
7.0
20
54
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
6.9
47
220
R02
ICPC
Shortness of breath/dyspnoea
3.6
6.8
25
81
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.2
6.7
32
122
D15.9
ICD-10 Finland
Benign neoplasm: Intrathoracic organ, unspecified
+∞
6.3
6
*
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
4.2
6.0
17
45

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
96
511
5.12
13.84
23.0
13.0
1.37
1.28
inr
0.35
23
151
34
120
3.54
8.20
1.3
1.3
—
—
—
0
0
62
320
2.91
7.75
2.3
2.2
—
—
—
0
0
54
283
2.63
6.26
5.7
4.1
—
—
—
0
0
31
129
2.88
5.53
14.0
6.3
14.11
11.64
kpa
1.12
31
122
31
129
2.88
5.53
14.0
6.3
5.37
5.08
kpa
0.56
31
122
31
131
2.83
5.37
14.0
6.3
1.72
1.51
mmol/l
0.09
26
101
47
254
2.38
4.88
3.6
2.0
2.99
3.09
mg/l
0.12
38
219
22
86
2.90
4.34
1.2
1.4
—
—
—
0
0
18
63
3.18
4.27
16.7
8.3
95.75
94.48
%
1.43
18
63
76
528
2.17
4.07
9.8
6.8
1.19
1.21
mmol/l
1.68
67
454
17
61
3.08
3.87
8.5
3.0
125.94
128.74
g/l
0.18
17
61
28
135
2.39
3.64
12.8
6.1
106.14
104.09
mmol/l
2.29
28
135
19
77
2.74
3.50
9.8
4.3
—
—
—
0
0
62
416
2.00
3.46
3.9
2.7
97.49
119.49
ug/l
0.55
57
379
9
18
5.31
3.44
1.4
7.9
—
—
—
0
0
70
492
1.99
3.40
12.7
5.9
1.18
1.21
mmol/l
2.54
65
445
51
321
2.01
3.40
4.0
4.1
7.43
7.40
ph
—
8
59
62
419
1.98
3.36
6.5
4.0
71.60
32.27
ng/l
1.20
46
306
67
475
1.91
3.07
7.4
6.3
—
—
—
0
0
78
591
1.89
2.81
11.4
9.9
4.22
4.14
e9/l
0.14
63
508
95
773
2.03
2.71
4.7
4.0
20.69
12.42
mm/h
2.64
89
703
9
25
3.80
2.63
4.7
2.7
—
—
—
0
0
23
120
2.13
2.46
1.8
1.4
388.00
543.70
titre
—
10
27
20
99
2.22
2.43
16.0
7.4
—
—
—
0
0
70
528
1.76
2.42
6.6
5.8
0.16
0.18
e9/l
0.57
55
456
7
17
4.30
2.39
2.3
2.2
71.63
60.46
%
—
7
17
107
930
2.22
2.25
4.8
4.8
1.95
1.98
mu/l
0.11
96
838
88
722
1.79
2.15
5.9
3.8
—
—
—
0
0
14
63
2.38
2.10
23.4
6.3
—
—
—
0
0
67
514
1.67
2.06
6.6
5.7
0.04
0.04
e9/l
0.19
52
437
67
514
1.67
2.06
6.6
5.6
0.59
0.59
e9/l
0.04
52
438
68
525
1.67
2.03
6.6
5.6
1.79
2.18
e9/l
0.86
55
460
7
21
3.47
1.99
1.4
1.1
—
—
—
0
0
18
93
2.10
1.97
6.9
3.3
5.52
4.63
kpa
0.54
18
88
11
46
2.53
1.91
9.0
3.3
28.35
24.38
mmol/l
1.76
11
46
20
109
2.00
1.91
7.2
4.1
6.29
5.68
kpa
1.47
20
104
109
971
2.15
1.87
4.8
4.8
5.99
5.98
mmol/l
0.03
97
879
46
328
1.65
1.83
5.1
3.3
—
—
—
0
0
24
144
1.83
1.74
1.3
1.3
—
—
—
0
0
53
396
1.60
1.73
2.1
2.2
—
—
—
0
0
14
69
2.16
1.72
1.4
2.4
—
—
—
0
0
11
49
2.37
1.69
6.9
2.6
0.69
0.70
%
0.05
11
49
71
571
1.58
1.68
7.0
6.2
10.33
11.28
umol/l
0.64
66
537
42
301
1.60
1.61
4.0
3.0
0.75
0.58
e6/l
0.17
30
219
55
421
1.56
1.59
2.2
2.0
100.56
95.37
pmol/l
0.32
36
202
59
459
1.55
1.58
5.5
4.2
34.46
35.24
g/l
0.50
51
431
42
303
1.59
1.56
7.5
4.3
—
—
—
0
0
111
1010
2.10
1.56
25.8
14.6
27.20
22.61
mg/l
0.86
101
796
35
242
1.63
1.54
1.4
1.3
—
—
—
0
0
17
95
1.92
1.52
2.5
2.5
74.72
68.95
e9/l
—
9
75
27
175
1.70
1.51
1.1
1.2
148.84
40.52
iu/ml
—
5
61
11
52
2.23
1.49
6.9
2.5
1.16
1.23
%
0.09
11
52
9
39
2.41
1.46
14.3
4.4
—
—
—
0
0
36
254
1.59
1.46
6.9
7.9
—
—
—
0
0
82
696
1.54
1.42
5.3
4.3
—
—
—
0
0
80
677
1.53
1.39
6.0
4.5
—
64.43
—
0
14
26
172
1.65
1.35
3.2
2.8
2.56
2.83
e6/l
0.09
13
96
25
164
1.66
1.34
1.2
1.2
19.17
9.01
u/ml
—
6
51
39
289
1.51
1.26
4.1
2.8
—
—
—
0
0
45
344
1.49
1.25
4.1
3.2
2.34
2.35
mmol/l
0.11
36
301
20
126
1.70
1.24
2.2
4.3
3.55
40.08
ug/l
0.59
14
109
5
19
2.70
1.23
1.0
1.4
—
—
—
0
0
88
772
1.50
1.19
3.4
4.0
15.01
14.86
pmol/l
0.25
78
693
5
20
2.56
1.16
1.0
1.6
—
—
—
0
0
5
21
2.44
1.10
7.6
3.3
6.08
7.16
mmol/l
—
5
21
103
942
1.60
1.06
5.9
6.0
39.38
40.57
mmol/mol
0.78
93
869
56
458
1.41
1.06
14.4
10.0
0.00
0.00
e9/l
0.91
42
362
7
36
2.00
0.99
1.4
1.5
—
—
—
0
0
102
937
1.54
0.96
4.2
4.1
1.19
1.27
mmol/l
1.01
94
847
32
240
1.45
0.96
4.2
3.7
—
—
—
0
0
13
78
1.75
0.96
1.4
1.5
—
—
—
0
0
7
37
1.94
0.95
1.7
1.2
—
—
—
0
0
14
87
1.69
0.92
1.3
1.6
—
—
—
0
0
21
146
1.53
0.90
2.1
1.7
—
—
—
0
0
47
382
1.37
0.90
4.7
3.6
58.75
81.35
e6/l
0.29
34
265
42
335
1.39
0.90
4.1
3.1
43.88
29.36
e6/l
0.37
31
248
29
218
1.43
0.86
1.6
1.4
3.31
2.40
g/l
0.75
18
116
112
1061
1.68
0.79
29.8
17.3
76.93
77.59
umol/l
0.08
112
1061
11
67
1.71
0.78
1.3
1.4
—
—
—
0
0
104
971
1.48
0.77
4.7
4.5
1.41
1.49
mmol/l
1.59
97
884
5
23
2.22
0.77
1.0
1.1
—
—
—
0
0
5
23
2.22
0.77
7.6
3.1
1.16
1.37
mmol/l
—
5
23
25
187
1.42
0.76
3.0
2.7
2.51
2.46
mmol/l
0.62
19
163
5
24
2.13
0.75
7.8
2.8
—
—
—
0
0
106
995
1.50
0.74
5.6
5.2
2.56
2.71
mmol/l
0.79
98
905
5
25
2.04
0.73
1.0
1.4
—
—
—
0
0
110
1043
1.56
0.70
24.4
14.0
—
—
—
0
0
110
1043
1.56
0.70
32.7
17.1
3.98
3.97
mmol/l
0.23
110
1017
5
27
1.89
0.69
1.0
1.1
—
—
—
0
0
5
27
1.89
0.69
1.6
1.3
0.27
0.23
g/l
—
5
27
27
209
1.37
0.68
1.4
1.8
372.92
484.44
pmol/l
1.89
19
171
5
28
1.82
0.67
1.8
1.4
1.16
1.12
g/l
—
5
28
5
29
1.75
0.64
1.0
1.1
—
—
—
0
0
104
980
1.41
0.63
4.8
4.6
4.37
4.62
mmol/l
1.56
96
903
8
49
1.68
0.63
4.6
4.9
—
—
—
0
0
12
80
1.55
0.62
3.7
4.6
1.23
1.22
mmol/l
0.16
12
71
0
20
0.00
0.61
0.0
1.2
—
—
—
0
0
8
52
1.58
0.61
6.1
4.9
—
—
—
0
0
6
36
1.70
0.57
16.2
14.1
—
—
—
0
0
7
48
1.49
0.47
1.0
1.3
—
—
—
0
0
56
501
1.22
0.46
4.8
3.9
0.00
0.00
estimate
-0.00
12
91
5
32
1.59
0.43
4.0
5.8
—
—
—
0
0
28
330
0.80
0.41
3.3
3.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
5
35
1.45
0.40
1.0
1.2
—
—
—
0
0
23
275
0.80
0.39
5.7
3.5
—
—
—
0
0
14
108
1.33
0.37
2.1
1.7
—
—
—
0
0
6
45
1.35
0.34
1.5
3.4
—
—
—
0
0
18
147
1.26
0.33
1.2
1.7
—
—
—
0
0
114
1113
1.37
0.30
37.4
21.5
4.35
4.46
e12/l
1.77
114
1076
114
1113
1.37
0.30
37.4
21.5
257.15
249.44
e9/l
0.51
114
1084
114
1113
1.37
0.30
37.4
21.5
6.88
6.75
e9/l
0.27
114
1078
114
1113
1.37
0.30
38.0
21.6
127.68
134.16
g/l
4.79
114
1095
114
1113
1.37
0.30
39.0
21.5
38.73
39.96
%
2.16
109
1035
114
1113
1.37
0.30
37.3
21.4
29.91
30.29
pg
1.35
114
1097
114
1113
1.37
0.30
37.4
21.4
90.84
91.14
fl
0.28
114
1097
54
496
1.16
0.30
4.9
3.8
0.00
0.01
estimate
0.50
12
106
54
498
1.15
0.28
6.5
5.1
0.00
0.00
estimate
-0.00
12
95
26
297
0.84
0.28
6.3
3.9
0.00
0.00
estimate
-0.00
12
91
5
73
0.67
0.27
1.2
1.6
—
—
—
0
0
12
96
1.28
0.25
1.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
27
244
1.14
0.18
1.7
1.3
1.29
1.39
u/ml
—
7
52
8
69
1.17
0.17
1.0
1.4
—
—
—
0
0
35
324
1.11
0.16
3.4
3.8
15.42
11.05
mg/mmol
0.14
24
199
6
76
0.78
0.16
1.0
1.4
—
—
—
0
0
11
126
0.86
0.12
2.4
2.0
119.18
166.56
ug/g
0.40
11
102
10
87
1.16
0.10
5.5
4.2
—
—
—
0
0
22
204
1.10
0.09
1.7
1.7
973.96
1240.15
nmol/l
0.81
17
157
7
67
1.05
0.08
1.3
2.0
5.92
8.57
e9/l
—
7
50
9
86
1.05
0.07
8.1
3.6
—
—
—
0
0
9
101
0.88
0.06
2.6
4.9
—
—
—
0
0
12
111
1.09
0.04
1.2
1.5
—
—
—
0
0
32
310
1.04
0.03
4.7
5.1
2.15
2.09
ug/l
0.02
26
271
31
301
1.04
0.02
2.7
3.2
1909.07
271.53
mg/l
0.40
21
197
12
114
1.06
0.01
1.7
1.4
—
—
—
0
0
28
281
1.00
0.00
1.6
1.7
1.33
1.28
mmol/l
0.20
23
235
18
183
0.98
0.00
3.0
3.0
2.09
0.73
ug/l
0.71
13
125
34
337
1.01
0.00
2.6
2.3
49.43
68.10
u/l
0.73
28
309
13
125
1.04
0.00
1.2
1.5
—
—
—
0
0
13
125
1.04
0.00
1.2
1.4
—
—
—
0
0
7
72
0.97
-0.00
4.6
2.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1720.17
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
30.20
—
0
5
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
66
0.90
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
3.45
—
0
6
0
5
0.00
-0.00
0.0
2.2
—
2790.00
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.8
—
42.17
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
11.29
—
0
7
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
172.44
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_HEART and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_HEART 1.784 [1.25, 2.54] 0.001
Birth year 0.995 [0.99, 1.0] 0.247

During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 322 females with CD2_BENIGN_HEART died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_HEART.

N-year risk Females Males
1 0.171% No data
5 1.002% No data
10 2.657% No data
15 5.205% No data
20 9.086% No data

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_HEART – Benign neoplasm: Heart

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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