male reproductive organ cancer: A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly males |
226837 |
2. Check conditionsNone |
226837 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
145 |
4. Check minimum number of eventsNone |
145 |
5. Include endpointsNone |
145 |
6. Filter based on genotype QC (FinnGen only) |
145 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D29
- Name in latin
- Neoplasma benignum scroti
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Scrotum
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Scrotum
- Benign neoplasm of male genital organs
- Benign neoplasm of male genital organs
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1111 | - | 1111 |
| Only index persons | 936 | - | 936 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | - | 0.03 |
| Only index persons | 0.04 | - | 0.04 |
| Median age at first event (years) | |||
| Whole population | - | - | 43.64 |
| Only index persons | - | - | 40.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 145 | - | 145 |
| Unadjusted period prevalence (%) | 0.06 | - | 0.06 |
| Median age at first event (years) | 48.02 | - | 48.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 137
- Matched controls
- 1369
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D29.4
ICD-10 Finland
Benign neoplasm: Scrotum
1181.5
119.6
100
*
22288
ICD-8 Finland
Benign neoplasm of male genital organs, Loco alio definito
+∞
24.7
23
*
22280
ICD-8 Finland
Benign neoplasm of male genital organs, Scroti
+∞
12.7
12
*
D40.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Testis
21.4
7.2
10
5
KFC00
NOMESCO Finland
Unilateral orchiectomy
42.2
6.8
8
*
KFD70
NOMESCO Finland
Excision of lesion of skin of scrotum
+∞
6.3
6
*
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
7.3
6.2
14
21
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
104
829
1.90
3.02
7.3
8.4
81.0
77.9
u/l
0.19
95
789
97
761
1.83
2.91
3.6
3.8
11.5
12.1
mm/h
0.15
85
710
55
366
1.81
2.87
3.3
2.4
165.3
191.0
ug/l
0.47
50
336
63
447
1.72
2.59
6.0
5.7
35.1
35.7
g/l
0.30
55
422
49
329
1.74
2.42
1.9
2.2
78.1
72.6
nmol/l
0.70
42
295
16
72
2.37
2.37
3.6
2.8
72.5
63.1
ml/min/173m2
0.65
11
34
83
646
1.67
2.34
4.8
5.2
6.3
6.9
mmol/l
3.11
77
615
54
377
1.69
2.30
1.9
1.9
84.4
87.3
pmol/l
0.17
30
213
35
220
1.78
2.15
1.5
1.9
441.4
411.1
pmol/l
0.36
28
195
106
890
1.71
2.15
3.7
3.7
1.9
2.0
mu/l
0.44
96
804
36
231
1.74
2.06
2.3
1.8
2.7
3.0
mg/l
0.36
27
204
118
1033
1.76
1.91
16.1
13.6
82.6
82.1
ml/min/173m2
0.09
100
844
63
485
1.53
1.70
6.5
7.8
1.2
1.2
mmol/l
1.89
48
417
29
186
1.70
1.65
1.5
1.7
1036.7
1194.1
nmol/l
0.48
20
144
84
691
1.51
1.64
3.1
2.9
14.4
14.8
pmol/l
0.83
78
615
96
813
1.54
1.63
4.3
4.7
1.7
2.4
ug/l
0.98
87
730
61
472
1.50
1.58
4.3
4.3
—
—
—
0
0
119
1068
1.64
1.46
17.2
14.9
27.9
26.5
mg/l
0.15
99
859
127
1166
1.72
1.33
10.7
10.7
29.7
30.1
u/l
0.07
119
1128
40
294
1.50
1.30
3.3
2.9
1.2
0.5
e6/l
0.23
33
214
72
593
1.43
1.29
9.4
10.5
3.9
4.2
e9/l
0.61
63
519
77
642
1.43
1.29
2.2
2.8
—
—
—
0
0
13
70
1.94
1.28
4.8
6.1
25.3
24.8
mmol/l
0.15
13
70
57
457
1.41
1.16
6.0
6.4
1.2
1.2
mmol/l
2.17
49
420
29
207
1.50
1.08
4.1
3.7
552.5
173.4
ng/l
0.31
24
174
33
244
1.46
1.03
1.9
2.5
—
—
—
0
0
7
35
2.05
1.01
1.3
1.3
40.6
37.6
g/l
—
7
27
13
77
1.76
0.99
1.5
1.3
—
—
—
0
0
88
772
1.36
0.99
3.1
3.6
60.5
59.0
u/l
0.06
80
728
114
1047
1.42
0.92
4.9
4.7
6.0
6.2
mmol/l
0.41
101
960
120
1113
1.45
0.91
5.0
5.0
2.6
2.7
mmol/l
0.56
109
1026
8
44
1.86
0.87
1.3
1.4
—
—
—
0
0
112
1032
1.37
0.83
7.1
6.1
40.7
40.7
mmol/mol
0.00
102
968
8
48
1.70
0.80
7.1
3.9
25.1
23.8
mmol/l
—
8
43
0
24
0.00
0.80
0.0
1.7
—
—
—
0
0
7
38
1.88
0.75
1.3
1.5
0.0
1.0
g/l
—
7
33
47
390
1.30
0.73
3.4
3.1
—
—
—
0
0
41
334
1.32
0.73
3.0
3.2
3399.7
1055.5
ng/l
1.31
31
278
7
40
1.79
0.72
1.1
2.3
—
—
—
0
0
7
40
1.79
0.72
1.3
1.4
2.9
3.1
g/l
—
7
29
117
1095
1.35
0.70
4.6
4.6
4.3
4.5
mmol/l
0.88
110
1020
34
271
1.33
0.70
1.6
1.7
1.7
1.5
mmol/l
0.51
28
228
124
1173
1.39
0.67
19.8
17.5
89.5
86.8
umol/l
0.30
124
1173
38
310
1.31
0.67
4.3
3.5
2.4
2.3
mmol/l
1.53
33
277
19
139
1.42
0.64
3.6
4.2
203.8
243.9
u/l
2.16
19
130
11
71
1.59
0.64
1.5
1.9
—
—
—
0
0
0
20
0.00
0.61
0.0
2.3
—
—
—
0
0
0
21
0.00
0.60
0.0
2.2
—
—
—
0
0
24
186
1.35
0.59
3.0
2.1
11.4
14.4
nmol/l
1.63
19
171
6
36
1.69
0.57
1.0
1.3
—
—
—
0
0
30
243
1.30
0.55
1.5
1.5
18.6
19.4
nmol/l
0.09
25
210
114
1076
1.28
0.54
4.2
4.1
1.4
1.4
mmol/l
0.14
106
998
7
106
0.64
0.51
1.6
1.8
—
—
—
0
0
115
1093
1.25
0.47
4.7
4.5
1.3
1.3
mmol/l
0.31
105
1012
9
128
0.68
0.45
1.8
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
2.2
—
—
—
0
0
0
16
0.00
0.41
0.0
2.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
1.5
—
0
6
0
16
0.00
0.41
0.0
2.2
—
—
—
0
0
9
66
1.39
0.39
1.6
1.8
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
258.1
—
0
12
32
277
1.20
0.34
3.2
3.2
0.0
0.0
estimate
0.49
14
85
8
63
1.29
0.28
1.5
1.8
—
—
—
0
0
16
132
1.24
0.27
5.8
4.7
27.0
28.8
%
—
10
91
71
667
1.13
0.26
3.7
4.2
20.4
20.9
%
0.11
35
316
52
480
1.13
0.25
2.7
2.9
0.6
0.7
ug/l
2.03
36
319
5
39
1.29
0.23
1.0
1.0
—
—
—
0
0
5
40
1.26
0.22
1.2
1.7
—
—
—
0
0
5
41
1.23
0.22
4.0
2.8
—
—
—
0
0
0
11
0.00
0.21
0.0
4.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
183.8
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
4.6
—
—
—
0
0
43
398
1.11
0.19
3.3
3.3
—
—
—
0
0
53
497
1.10
0.19
3.1
3.2
0.0
0.0
estimate
0.00
14
93
25
224
1.14
0.18
1.6
1.7
0.7
1.6
mg/l
2.30
18
177
7
89
0.78
0.15
1.3
1.8
394.7
364.1
nmol/l
—
7
80
17
189
0.89
0.12
1.2
1.3
4.5
1.1
u/ml
—
6
59
49
467
1.07
0.12
4.1
3.9
66.9
49.1
ng/l
0.20
35
339
33
310
1.08
0.11
2.6
2.8
383.8
5547.3
umol/l
1.04
27
266
53
509
1.07
0.10
3.0
3.2
0.0
0.0
estimate
0.00
14
84
52
500
1.06
0.09
4.0
4.3
0.0
0.0
estimate
0.00
14
93
7
83
0.84
0.07
9.7
8.2
27.2
23.8
mmol/l
—
7
78
20
187
1.08
0.07
1.4
2.0
—
—
—
0
0
20
190
1.06
0.04
3.4
2.4
0.8
0.8
e6/l
0.07
11
108
12
128
0.93
0.02
1.2
1.3
20.9
35.1
iu/ml
—
5
39
13
137
0.94
0.01
8.8
8.3
12.4
11.4
kpa
0.34
13
132
13
137
0.94
0.01
1.5
1.9
—
—
—
0
0
19
184
1.04
0.00
3.8
2.6
0.5
0.4
e6/l
0.30
12
103
12
121
0.99
0.00
3.7
8.4
—
—
—
0
0
14
135
1.04
0.00
1.4
1.9
—
—
—
0
0
12
125
0.96
0.00
4.2
3.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
6.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
6.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
18.0
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
9.8
—
0
9
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
0
7
0.00
0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
8
87
0.91
0.00
1.6
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
112.4
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_SCROTUM and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_SCROTUM | 1.306 [0.98, 1.74] | 0.067 |
| Birth year | 0.985 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 605 males with CD2_BENIGN_SCROTUM died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_SCROTUM.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.253% |
| 5 | No data | 1.561% |
| 10 | No data | 3.61% |
| 15 | No data | 6.871% |
| 20 | No data | 11.442% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_SCROTUM – Benign neoplasm: Scrotum
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data