No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleonly females |
- |
2. Check conditions
|
- |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF9
- Parent code in ICD-10
- D00-D09
- Name in latin
- Carcinoma in situ vulvae
Carcinoma in situ of breast
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7107 | 7107 | - |
| Only index persons | 6938 | 6938 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.20 | 0.20 | - |
| Only index persons | 0.26 | 0.26 | - |
| Median age at first event (years) | |||
| Whole population | - | 60.20 | - |
| Only index persons | - | 60.15 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 166 | 166 | - |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | - |
| Median age at first event (years) | 60.25 | 60.25 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 124
- Matched controls
- 1240
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
+∞
121.8
96
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
49.3
44
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
33.9
31
*
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
115.6
32.6
34
*
HAB40
NOMESCO Finland
Wedge excision of mammary gland
357.8
29.0
28
*
HAB99
NOMESCO Finland
Other partial excision of mammary gland
56.9
23.5
27
6
HAB50
NOMESCO Finland
Partial excision of mammary gland with reconstructive operation
+∞
20.4
19
*
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
125.2
20.2
21
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
18.2
17
*
D05.0
ICD-10 Finland
Lobular carcinoma in situ
+∞
18.2
17
*
D05.9
ICD-10 Finland
Carcinoma in situ of breast, unspecified
+∞
17.1
16
*
WX402
NOMESCO Finland
General anaesthesia
7.0
16.1
44
90
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
16.0
15
*
HA1AA
NOMESCO Finland
X-ray mammography
14.0
15.7
27
24
XX3DW
NOMESCO Finland
Time consuming IT work
14.0
15.7
27
24
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
169.1
14.8
15
*
N63
ICD-10 Finland
Unspecified lump in breast
12.7
14.0
25
24
D48.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Breast
26.0
13.3
18
8
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.3
12.4
60
223
WZC30
NOMESCO Finland
Teaching
7.3
12.0
30
52
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
11.6
11
*
C50.99
ICD-10 Finland
Breast, unspecified
+∞
11.6
11
*
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
11.7
11.0
20
20
HA1AT
NOMESCO Finland
Biopsy of mammary glands with ultrasound guidance
59.8
9.8
11
*
HAB00
NOMESCO Finland
Excision of lesion of mammary gland
14.0
9.1
15
12
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
15.6
8.9
14
10
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
8.4
8
*
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
+∞
8.4
8
*
HAC15
NOMESCO Finland
Subcutaneous mastectomy with excision of mamilla
+∞
8.4
8
*
D24
ICD-10 Finland
Benign neoplasm of breast
10.4
7.5
14
15
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
85.0
7.5
8
*
XX1XN
NOMESCO Finland
Other isotope examination
+∞
7.4
7
*
WF002
NOMESCO Finland
Radical radiotherapy
+∞
7.4
7
*
N64.5
ICD-10 Finland
Other signs and symptoms in breast
10.2
7.0
13
14
HAA10
NOMESCO Finland
Biopsy of mammary gland
42.4
6.8
8
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
73.5
6.5
7
*
N60.8
ICD-10 Finland
Other benign mammary dysplasias
73.5
6.5
7
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
6.3
6
*
HAE00
NOMESCO Finland
Reconstruction of breast using prosthesis
+∞
6.3
6
*
HAE10
NOMESCO Finland
Reconstruction of breast using graft or flap
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint CD2_INSITU_BREAST_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_INSITU_BREAST_EXALLC | 0.892 [0.79, 1.01] | 0.068 |
| Birth year | 0.995 [0.99, 1.0] | 0.206 |
During the follow-up period (1.1.1998 — 31.12.2019), 553 out of 5965 females with CD2_INSITU_BREAST_EXALLC died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have CD2_INSITU_BREAST_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.074% | No data |
| 5 | 0.47% | No data |
| 10 | 1.217% | No data |
| 15 | 2.416% | No data |
| 20 | 4.331% | No data |
Relationships between endpoints
↥Index endpoint: CD2_INSITU_BREAST_EXALLC – Carcinoma in situ of breast
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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