Carcinoma in situ of breast

CD2_INSITU_BREAST_EXALLC

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data
1. Apply sex-specific rule only females	-
2. Check conditions not C3_BREAST	-
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D05 Cause of death: ICD-10 — D05 Cancer registry: Topography ICD-O-3 — C50 Cancer registry: Morphology ICD-O-3 — ANY Cancer registry: Behaviour codes — 2 3 out of 7 registries used, show all original rules.	-
4. Check minimum number of events None	-
5. Include endpoints CD2_INSITU_BREAST_LOBULAR CD2_INSITU_BREAST_INTRADUCTAL CD2_INSITU_BREAST_NOS	-
6. Filter based on genotype QC (FinnGen only) None	-

Control definitions (FinnGen only)

Control exclude: C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy: 2
First used in FinnGen datafreeze: DF9
Parent code in ICD-10: D00-D09
Name in latin: Carcinoma in situ vulvae

NAME	CD2_INSITU_BREAST_EXALLC
CONTROL_EXCLUDE	C3_CANCER\|C3_CANCER_WIDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE	CD2_INSITU_BREAST_LOBULAR\|CD2_INSITU_BREAST_INTRADUCTAL\|CD2_INSITU_BREAST_NOS
PRE_CONDITIONS
CONDITIONS	!C3_BREAST
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D05
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D05
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C50
CANC_TOPO_EXCL
CANC_MORPH	ANY
CANC_MORPH_EXCL
CANC_BEHAV	2

Similar endpoints

↥

List of similar endpoints to Carcinoma in situ of breast based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Carcinoma in situ of breast

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	7107	7107	-
Only index persons	6938	6938	-
Unadjusted period prevalence (%)
Whole population	0.20	0.20	-
Only index persons	0.26	0.26	-
Median age at first event (years)
Whole population	-	60.20	-
Only index persons	-	60.15	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	166	166	-
Unadjusted period prevalence (%)	0.06	0.06	-
Median age at first event (years)	60.25	60.25	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
124: Matched controls
1240

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D05.1

ICD-10 Finland

Intraductal carcinoma in situ

+∞

121.8

PJA12

NOMESCO Finland

Sentinel node biopsy

+∞

49.3

HA003

NOMESCO Finland

Radiotherapy after partial ablation of mammary gland

+∞

33.9

HA6AA

NOMESCO Finland

Extra corporeal mammography of operated mammary gland

115.6

32.6

HAB40

NOMESCO Finland

Wedge excision of mammary gland

357.8

29.0

HAB99

NOMESCO Finland

Other partial excision of mammary gland

56.9

23.5

HAB50

NOMESCO Finland

Partial excision of mammary gland with reconstructive operation

+∞

20.4

HA4AT

NOMESCO Finland

Labeling mammary gland pathology with ultrasound guidance

125.2

20.2

HAC20

NOMESCO Finland

Total mastectomy

+∞

18.2

D05.0

ICD-10 Finland

Lobular carcinoma in situ

+∞

18.2

D05.9

ICD-10 Finland

Carcinoma in situ of breast, unspecified

+∞

17.1

WX402

NOMESCO Finland

General anaesthesia

7.0

16.1

YG1AD

NOMESCO Finland

CT examination of thorax for dose design of radiotherapy

+∞

16.0

XX3DW

NOMESCO Finland

Time consuming IT work

14.0

15.7

HA1AA

NOMESCO Finland

X-ray mammography

14.0

15.7

PJ5AN

NOMESCO Finland

Localisation of sentinell lymphnode with isotope imaging

169.1

14.8

N63

ICD-10 Finland

Unspecified lump in breast

12.7

14.0

D48.6

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Breast

26.0

13.3

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

4.3

12.4

223

WZC30

NOMESCO Finland

Teaching

7.3

12.0

C50.99

ICD-10 Finland

Breast, unspecified

+∞

11.6

C50.41

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor

+∞

11.6

HA1AE

NOMESCO Finland

Ultrasound examination of mammary glands

11.7

11.0

HA1AT

NOMESCO Finland

Biopsy of mammary glands with ultrasound guidance

59.8

9.8

HAB00

NOMESCO Finland

Excision of lesion of mammary gland

14.0

9.1

WZC20

NOMESCO Finland

Multidisciplinary treatment meeting

15.6

8.9

HAC15

NOMESCO Finland

Subcutaneous mastectomy with excision of mamilla

+∞

8.4

WB113

NOMESCO Finland

Multiple adjuvant cytostatic therapy

+∞

8.4

C50.81

ICD-10 Finland

Overall malignant tumor of the mammary gland, ductal tumor

+∞

8.4

D24

ICD-10 Finland

Benign neoplasm of breast

10.4

7.5

WB103

NOMESCO Finland

Simple adjuvant cytostatic therapy

85.0

7.5

WF002

NOMESCO Finland

Radical radiotherapy

+∞

7.4

XX1XN

NOMESCO Finland

Other isotope examination

+∞

7.4

N64.5

ICD-10 Finland

Other signs and symptoms in breast

10.2

7.0

HAA10

NOMESCO Finland

Biopsy of mammary gland

42.4

6.8

N60.8

ICD-10 Finland

Other benign mammary dysplasias

73.5

6.5

ZX012

NOMESCO Finland

Radiotherapy with large shaped fields - isocentric therapy

73.5

6.5

HAE00

NOMESCO Finland

Reconstruction of breast using prosthesis

+∞

6.3

HAE10

NOMESCO Finland

Reconstruction of breast using graft or flap

+∞

6.3

YG1BD

NOMESCO Finland

Extensive CT examination of thorax for dose design of radiotherapy

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768793) Breast Pathology biopsy report

32.69

70.65

1.5

1.1

—

(4035726)

21.25

59.69

1.5

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

122

565

5.37

22.48

3.6

3.5

—

(3044640) Blood type and Crossmatch panel - Blood

337

3.08

11.20

1.8

2.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

+∞

10.52

1.1

0.0

—

(40768804) Tissue Pathology biopsy report

510

2.74

9.28

2.4

1.7

—

(3002256) Pathology report gross observation

118

3.49

8.84

1.5

1.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

257

2.85

8.79

1.9

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

104

643

2.65

8.42

5.4

3.3

9.0

10.6

umol/l

1.06

597

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

4.03

8.22

3.0

1.4

2.0

2.9

ug/l

1.39

(3003694) ABO and Rh group [Type] in Blood

322

2.54

7.39

1.2

1.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

106

723

2.29

6.08

7.2

5.9

3.9

4.1

e9/l

0.23

624

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

648

2.14

5.41

4.7

1.2

mmol/l

0.17

554

(3018418) pH of Serum or Plasma

384

1.98

4.14

3.8

3.1

7.4

0.49

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.62

3.36

2.0

1.4

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

586

1.75

3.11

4.7

4.6

1.2

mmol/l

0.79

519

(40758558) Short blood count panel - Blood

289

1.87

3.10

4.6

4.5

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

542

1.74

3.05

4.7

3.2

37.0

36.4

g/l

0.36

507

(3019550) Sodium [Moles/volume] in Serum or Plasma

160

1469

3.47

3.05

14.2

12.2

139.9

mmol/l

0.03

160

1423

(3023103) Potassium [Moles/volume] in Serum or Plasma

160

1473

3.38

2.89

14.4

12.3

3.9

mmol/l

0.22

160

1424

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

5.17

2.76

1.3

1.1

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

4.82

2.62

1.3

1.1

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

4.82

2.62

1.3

1.1

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

4.52

2.50

1.6

1.1

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

4.52

2.50

1.6

1.1

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

4.52

2.50

1.6

1.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

3.34

2.34

1.2

1.1

—

(3042936) Bacteria identified in Isolate by Culture

161

1.89

2.23

2.0

1.9

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

3.80

2.17

1.4

1.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

118

2.00

2.14

2.3

1.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

112

2.00

2.07

2.0

1.8

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

451

1.56

1.94

2.1

1.9

2.4

mmol/l

1.28

381

(3033658) Prothrombin time (PT) actual/Normal

302

1.62

1.91

3.0

2.7

102.9

97.9

0.74

290

(3013512) EKG study

402

1.55

1.83

3.6

3.3

—

(3022145) Colonoscopy Study observation

166

1.75

1.6

1.3

—

(40768443) Skin Pathology biopsy report

2.38

1.74

1.1

1.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.66

1.68

1.1

1.2

—

(42870588) Differential panel, method unspecified - Blood

419

1.51

1.65

5.9

5.0

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.57

1.62

1.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

148

1362

1.80

1.56

12.3

9.5

83.7

80.6

ml/min/173m2

1.16

126

1081

(3019225) pH of Specimen

127

1.75

1.45

2.9

3.0

—

(3008037) Lactate [Moles/volume] in Venous blood

2.79

1.45

1.2

2.6

1.6

1.4

mmol/l

—

(3021589) Normoblasts [#/volume] in Blood

589

1.43

9.4

7.2

0.0

e9/l

0.84

479

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.25

1.43

1.0

1.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

2.67

1.38

1.0

1.7

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

3.00

1.37

1.0

1.1

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

3.00

1.37

1.4

1.2

—

(3013115) Eosinophils [#/volume] in Blood

691

1.40

1.34

6.0

5.2

0.2

e9/l

0.54

608

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.42

1.31

1.4

1.1

—

(3044889) 12 lead EKG panel

115

1019

1.42

1.26

3.6

3.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

313

1.46

1.24

1.4

1.6

0.7

1.0

mg/l

1.00

242

(3032080) INR in Blood by Coagulation assay

460

1.40

1.22

6.8

6.5

1.2

inr

0.15

141

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

192

1.55

1.22

4.1

4.4

32.5

33.5

0.18

117

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

118

1.69

1.21

1.7

3.2

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

2.00

1.20

1.0

1.3

—

2.3

—

(3000494) Fungus identified in Specimen by Culture

176

1.57

1.19

1.2

1.3

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

1.17

0.0

1.5

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

317

1.43

1.16

1.1

1.4

12.8

42.9

iu/ml

—

119

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.54

1.16

1.2

1.1

—

(40761511) CBC panel - Blood by Automated count

157

1495

1.92

1.15

13.7

10.1

—

(3001604) Monocytes [#/volume] in Blood

658

1.35

1.10

6.3

4.7

0.6

e9/l

0.21

566

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

160

1537

2.13

1.10

11.5

8.4

24.6

23.3

u/l

0.44

160

1471

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

1.93

1.10

1.0

1.3

—

3.9

—

(3019198) Lymphocytes [#/volume] in Blood

679

1.34

1.08

6.1

4.7

1.9

2.0

e9/l

0.22

592

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

2.31

1.04

1.4

1.2

—

nmol/l

—

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

1.92

1.02

1.0

1.2

—

43.8

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.92

1.02

1.0

1.2

—

13.7

—

(3006315) Basophils [#/volume] in Blood

664

1.33

1.02

6.3

4.7

0.0

e9/l

0.18

567

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.98

0.0

1.1

—

2.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.21

0.98

1.2

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.75

0.98

1.2

1.5

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

1.77

0.88

1.0

1.2

—

1.0

—

(4010399)

115

0.50

0.86

1.8

1.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

147

1392

1.49

0.85

3.9

4.1

1.3

1.2

mmol/l

0.06

140

1272

(3019060) Gas panel - Arterial blood

1.74

0.84

2.0

6.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

139

1.50

0.84

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.91

0.82

1.3

1.1

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.80

0.0

1.8

—

4.9

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.80

0.0

1.3

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.80

0.0

1.0

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.80

0.0

2.6

—

61.9

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.79

0.0

1.0

—

(3029937) Albumin [Presence] in Urine by Test strip

372

0.73

0.77

4.8

3.8

0.0

estimate

—

122

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

359

1.31

0.75

1.6

1.4

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

2.12

0.75

1.4

1.2

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.12

0.75

1.0

1.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.59

0.74

1.4

1.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

155

1491

1.60

0.73

4.9

5.1

3.0

2.9

mmol/l

0.51

147

1375

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

2.03

0.73

1.2

1.9

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.61

0.72

1.6

1.5

—

(3022313) Gas panel - Capillary blood

1.78

0.72

1.7

3.9

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

153

1469

1.53

0.72

4.4

4.6

5.0

4.9

mmol/l

0.45

147

1358

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

1.95

0.71

1.4

1.2

—

nmol/l

—

(3049717) Cytology report of Urine Cyto stain

1.88

0.69

1.4

1.9

—

(21494755) Public health laboratory ask at order entry panel

138

0.63

0.64

1.0

1.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

162

0.66

0.62

1.6

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

1.69

0.62

1.4

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.61

0.0

1.2

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.61

0.0

1.6

—

(3021960) Folate [Moles/volume] in Serum or Plasma

327

0.76

0.60

1.5

23.4

23.8

nmol/l

0.03

284

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.60

0.0

1.7

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.60

0.0

1.0

—

(3015736) pH of Urine

562

1.23

0.59

3.4

3.3

—

(1761868) Lipid panel - Serum or Plasma

526

1.22

0.56

2.7

2.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

105

973

1.22

0.55

4.5

4.1

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

439

0.80

0.55

1.8

1.6

1.4

mmol/l

0.18

373

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.48

0.54

1.4

1.5

—

(3013707) Erythrocyte sedimentation rate by Westergren method

118

1109

1.22

0.52

4.9

4.2

11.3

11.6

mm/h

0.09

112

1020

(3007566) Smooth muscle Ab [Titer] in Serum

1.52

0.52

1.2

1.1

—

80.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

151

1460

1.38

0.51

4.4

4.5

1.6

mmol/l

0.01

144

1350

(3000850) Epithelial cells [#/volume] in Urine

264

1.26

0.51

1.9

2.5

6.8

7.5

e6/l

0.12

235

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

255

1.27

0.50

3.3

3.6

71.5

305.1

ng/l

0.46

183

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.45

0.46

2.4

1.8

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

325

1.22

0.45

2.1

2.8

303.7

1086.7

ng/l

3.35

261

(3037522) Nuclear Ab [Titer] in Serum

222

1.26

0.44

1.4

213.3

729.5

titre

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.64

0.43

1.2

1.5

—

(3026493) Urate [Moles/volume] in Serum or Plasma

334

0.81

0.43

1.9

2.0

308.0

6074.3

umol/l

1.60

286

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

1.53

0.41

1.2

2.1

1.0

0.5

ug/l

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.41

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.41

0.0

1.4

—

(3016701) Glucose [Moles/volume] in Serum or Plasma --2 hours post dose glucose

0.00

0.41

0.0

1.2

—

6.9

—

(3009991) Angiotensin converting enzyme [Enzymatic activity/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.0

—

1.1

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

253

1.23

0.40

2.5

1.9

2.5

2.4

mmol/l

0.59

218

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.43

0.40

1.3

1.9

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.40

0.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.39

0.0

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.39

0.0

1.5

—

(3027456) Digoxin [Moles/volume] in Serum or Plasma

0.00

0.39

0.0

3.5

—

0.8

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.39

0.0

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.39

0.0

1.5

—

(1002224) Polysomnography panel

1.36

0.39

1.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.40

0.38

1.4

1.7

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.40

0.38

1.4

1.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

162

1.27

0.37

1.4

1.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

117

1.31

0.36

1.3

1.4

—

(3000492) Spirometry study

117

1.31

0.36

1.4

1.3

—

(3023368) Bacteria identified in Blood by Culture

256

1.21

0.36

3.5

3.6

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

1.48

0.36

1.8

1.6

375.8

308.7

mu/l

—

(3022621) pH of Urine by Test strip

0.65

0.33

2.0

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

316

1.18

0.33

1.3

6.1

11.8

u/ml

0.46

133

(3026782) Osmolality of Urine

231

1.20

0.32

1.7

2.6

485.8

516.8

mosm/kgh2o

0.25

204

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.28

0.30

3.7

8.8

—

(40761536) Microorganisms panel - Urine sediment

106

0.74

0.30

2.5

3.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

271

1.18

0.30

1.8

1.5

—

(3003338) MCHC [Mass/volume]

126

1217

1.15

0.28

16.8

13.9

331.4

330.8

g/l

0.30

126

1212

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

216

1.19

0.27

1.9

2.3

1.1

1.2

e6/l

0.04

115

(3000963) Hemoglobin [Mass/volume] in Blood

161

1588

1.46

0.26

20.8

15.7

133.8

133.5

g/l

0.13

161

1558

(3024731) MCV [Entitic volume]

161

1587

1.48

0.26

20.7

15.6

90.8

0.06

161

1559

(3035941) MCH [Entitic mass]

161

1587

1.48

0.26

20.6

15.6

30.1

0.07

161

1559

(40760892) CBC W Ordered Manual Differential panel - Blood

317

0.86

0.26

4.2

3.7

—

(3002582) Erythrocytes [#/volume] in Urine

371

1.14

0.26

2.4

3.0

14.5

64.5

e6/l

1.52

281

(36304419) Bacteria [Presence] in Urine

342

1.14

0.26

2.4

2.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

295

0.86

0.25

1.9

1.3

1.8

2.4

g/l

—

180

(3000991) Gas panel - Venous blood

1.30

0.25

4.1

6.6

—

(3018095) Leukocytes [#/volume] in Urine

461

1.12

0.24

3.1

3.5

106.3

77.5

e6/l

0.12

311

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

172

1.19

0.23

1.8

1.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

125

1.22

0.23

1.9

1.6

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

191

1.18

0.23

1.9

2.6

2.1

4.0

e6/l

0.76

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

1.26

0.22

1.8

1.3

0.0

g/l

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

1.26

0.22

1.8

1.4

0.0

0.1

g/l

—

(3002385) Erythrocyte distribution width [Ratio]

122

1183

1.12

0.22

17.8

12.9

13.5

13.6

0.48

122

1159

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

126

1.21

0.22

1.9

1.6

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.21

0.0

1.7

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

0.21

0.0

1.3

—

158.2

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

4.5

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

1.8

—

10.8

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

337

1.13

0.21

4.2

3.3

—

(3020191) Ethanol [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

0.6

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.21

0.0

1.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(40768797) Stomach Pathology biopsy report

212

1.15

0.21

1.3

1.2

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

918

0.91

0.20

3.2

2.9

—

(4027681)

0.00

0.20

0.0

1.1

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.20

0.0

2.3

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.20

0.0

1.0

—

(3030467) Casts [#/volume] in Urine by Automated count

348

1.12

0.20

2.4

2.8

0.1

0.4

e6/l

1.39

255

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

196

0.85

0.20

6.0

4.8

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

141

1382

1.13

0.18

5.6

5.5

39.2

39.3

mmol/mol

0.08

132

1291

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.17

0.18

1.3

1.6

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

1.13

0.17

1.1

2.3

31.4

41.8

u/l

—

(3045414) Leukocytes [Presence] in Urine

0.73

0.17

1.2

1.7

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

440

1.10

0.17

2.6

2.9

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

658

1.08

0.16

2.6

2.2

80.8

80.3

nmol/l

0.06

588

(3009542) Hematocrit [Volume Fraction] of Blood

132

1293

1.10

0.15

15.0

11.5

37.9

39.8

1.21

100

938

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.20

0.15

3.2

2.0

0.2

g/l

0.67

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.20

0.14

1.1

1.0

—

(3012516) Albumin [Mass/volume] in Urine

414

1.09

0.14

3.0

3.1

13.5

377.4

mg/l

0.85

242

(3041096) Erythrocytes [Presence] in Urine by Automated

395

0.92

0.13

2.4

3.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

557

0.93

0.13

3.5

—

(3009261) Glucose [Presence] in Urine by Test strip

717

1.06

0.10

3.5

0.0

estimate

—

117

(3009508) Creatinine [Moles/volume] in Urine

439

1.07

0.10

2.7

3.0

6.2

6.8

mmol/l

0.52

362

(4094501)

1.17

0.10

1.0

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.14

0.10

1.4

3.2

33.7

46.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.05

0.08

2.3

1.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.06

0.08

9.0

5.5

23.2

25.6

mmol/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

127

1.11

0.08

2.2

1.6

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

133

0.89

0.08

1.3

1.2

152.0

139.3

iu/ml

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

143

0.90

0.07

1.7

2.0

310.9

362.1

nmol/l

0.56

137

(3025941) Bacteria identified in Stool by Culture

1.03

0.07

1.8

1.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

140

1414

0.94

0.07

13.3

10.3

15.5

19.7

mg/l

1.46

119

1036

(3020682) Albumin/Creatinine [Ratio] in Urine

435

1.05

0.06

3.2

3.8

5.5

5.2

mg/mmol

0.02

247

(3035350) Ketones [Presence] in Urine by Test strip

715

1.04

0.05

3.5

0.0

estimate

—

122

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

317

1.05

0.05

2.4

2.2

3.1

mg/l

2.24

266

(3026008) Bacteria identified in Urine by Culture

437

1.04

0.05

2.4

2.8

—

(3019150) Specific gravity of Urine by Refractometry

338

1.04

0.04

4.0

3.7

1.0

kg/l

—

(3012544) pH of Venous blood

101

1.10

0.04

1.0

3.5

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

111

1.09

0.04

1.3

1.5

—

(40761535) Cells panel - Urine sediment

111

1.09

0.04

3.0

2.7

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

361

0.96

0.04

1.5

1.3

0.5

2.6

u/ml

—

112

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

581

1.02

0.02

2.2

1.9

100.7

99.8

pmol/l

0.05

266

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

488

0.98

0.01

2.7

3.2

10.5

20.0

ng/l

4.39

305

(46235355) HIV 1 and 2 tests - Meaningful Use set

193

1.04

0.01

2.4

1.7

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

146

1453

1.04

0.01

4.7

4.5

5.9

5.8

mmol/l

0.34

136

1339

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

123

1223

1.02

0.01

6.0

4.3

14.7

14.6

pmol/l

0.20

115

1132

(3019309) Folate [Moles/volume] in Red Blood Cells

246

0.97

0.00

2.3

1.6

980.4

1269.3

nmol/l

0.90

183

(3017732) Neutrophils [#/volume] in Blood

1.01

0.00

1.3

2.3

4.6

3.8

e9/l

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

101

0.99

0.00

2.0

3.2

214.7

247.9

u/l

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

101

0.99

0.00

1.1

2.7

51.6

157.3

ng/l

—

(3020630) Protein [Mass/volume] in Serum or Plasma

101

0.99

0.00

1.4

1.5

67.6

68.2

g/l

—

(36660697) Celiac disease serology panel - Serum

119

1.01

0.00

1.6

1.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

119

1.01

0.00

1.2

1.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

713

0.99

0.00

5.0

4.8

0.0

estimate

—

118

(3002032) Base excess in Venous blood by calculation

1.06

0.00

1.0

3.4

4.3

2.4

mmol/l

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

2.1

—

6.5

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.0

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.4

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.4

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.3

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

120.5

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1987.0

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.4

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

2.1

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.0

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3044936) Clostridioides difficile toxin A+B [Presence] in Stool by Immunoassay

0.00

0.0

1.0

—

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

1.00

0.00

1.6

1.3

44.4

66.4

pmol/l

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.8

—

208.4

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(37020300) Entamoeba histolytica DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.94

0.00

1.8

1.3

3.5

4.0

g/l

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.98

0.00

1.8

1.3

7.9

11.0

g/l

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

150

1.00

0.00

1.5

1.7

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3000330) Specific gravity of Urine by Test strip

1.00

0.00

1.6

2.6

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.4

—

295.5

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

5.6

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.1

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3011436) Histone Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(4034850)

1.02

0.00

1.7

6.3

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.2

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.3

—

(3008898) HLA-B27 [Presence]

0.86

0.00

1.0

1.1

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.86

0.00

2.5

1.5

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(42868415) European tick borne encephalitis virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.02

0.00

1.0

4.0

28.4

24.8

mmol/l

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.89

0.00

1.5

1.3

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.00

0.00

1.8

1.3

2.4

3.2

g/l

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.2

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.94

0.00

1.8

1.3

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.4

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk

0.00

0.0

1.2

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

12.1

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(42868766) Dientamoeba fragilis DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

2.4

—

18.0

—

(3017704) Immunofixation for Urine

0.00

0.0

1.2

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

30.1

—

(42868417) European tick borne encephalitis virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.94

0.00

1.8

1.3

6.9

7.9

g/l

—

(4198724)

0.00

0.0

1.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.8

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_INSITU_BREAST_EXALLC and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_INSITU_BREAST_EXALLC	0.892 [0.79, 1.01]	0.068
Birth year	0.995 [0.99, 1.0]	0.206

During the follow-up period (1.1.1998 — 31.12.2019), 553 out of 5965 females with CD2_INSITU_BREAST_EXALLC died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_INSITU_BREAST_EXALLC.

N-year risk	Females	Males
1	0.074%	No data
5	0.47%	No data
10	1.217%	No data
15	2.416%	No data
20	4.331%	No data

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_BREAST_EXALLC – Carcinoma in situ of breast

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Carcinoma in situ of breast

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints