No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
397 |
6. Filter based on genotype QC (FinnGen only) |
397 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D80-D89
- Name in latin
- Deficientiae immunales mixtae
Similar endpoints
↥List of similar endpoints to
Combined immunodeficiencies
based on the number of shared cases.
Similar with more cases:
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3113 | 1722 | 1368 |
| Only index persons | 2640 | 1511 | 1129 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 56.62 | 54.81 | 58.78 |
| Only index persons | 54.63 | 53.01 | 56.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 397 | 242 | 155 |
| Unadjusted period prevalence (%) | 0.08 | 0.08 | 0.07 |
| Median age at first event (years) | 54.01 | 49.17 | 61.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 365
- Matched controls
- 3650
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D81.4
ICD-10 Finland
Nezelof syndrome
+∞
161.8
143
*
D81.0
ICD-10 Finland
Severe combined immunodeficiency [SCID] with reticular dysgenesis
+∞
107.8
98
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
11.8
69.0
141
184
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
10.9
53.6
111
140
D81.8
ICD-10 Finland
Other combined immunodeficiencies
+∞
49.1
46
*
D81.9
ICD-10 Finland
Combined immunodeficiency, unspecified
+∞
32.8
31
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
6.6
24.3
66
118
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
20.0
19
*
D81.2
ICD-10 Finland
Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
+∞
20.0
19
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.9
19.5
89
277
D81.1
ICD-10 Finland
Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
+∞
18.9
18
*
N02AX02
ATC
tramadol; systemic, rectal
2.7
18.7
195
1077
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
17.9
137
619
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
17.4
192
1080
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
17.2
145
694
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
16.8
16
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.6
15.7
79
263
J01MA12
ATC
levofloxacin; systemic
3.2
15.5
96
371
C03CA01
ATC
furosemide; systemic
2.6
15.2
144
725
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.2
15.1
48
103
J01FF01
ATC
clindamycin; systemic
2.7
14.9
127
601
P01AB01
ATC
metronidazole; oral, rectal
2.4
13.9
173
998
J01DA01
ATC
[U] cefalexin; systemic
2.4
13.4
250
1746
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.7
13.3
103
457
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
10.6
13.2
25
25
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.8
13.0
37
70
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.0
12.9
84
333
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
12.6
12
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.5
12.2
61
200
Z01.8
ICD-10 Finland
Other specified special examinations
2.6
12.2
101
462
D81.3
ICD-10 Finland
Adenosine deaminase [ADA] deficiency
+∞
11.5
11
*
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
11.5
11
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
11.5
11
*
R50.9
ICD-10 Finland
Fever, unspecified
3.0
11.2
70
267
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.4
11.1
55
179
J01MA02
ATC
ciprofloxacin; systemic
2.2
11.1
161
969
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
11.0
96
448
R4110
NOMESCO Finland
Physiotherapy
2.3
10.5
118
627
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
12.5
10.5
18
15
LWE00
NOMESCO Finland
Reoperation for deep haemorrhage in gynaecological surgery
33.6
10.4
13
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
10.5
10.1
19
19
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.6
10.1
35
83
WX002
NOMESCO Finland
Sedation and analgesia
2.5
9.8
86
402
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.9
9.8
40
111
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
6.7
9.7
24
38
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
9.6
141
837
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.0
9.5
186
1240
X59
ICD-10 Finland
Exposure to unspecified factor
2.4
9.4
85
404
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
9.3
56
207
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.3
9.2
46
151
H02AB06
ATC
prednisolone; systemic
2.0
9.2
180
1198
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
9.1
76
344
JN3AD
NOMESCO Finland
Abdominal CT examination
3.5
9.1
42
130
ZXA00
NOMESCO Finland
Right side
2.1
9.0
120
679
UJF32
NOMESCO Finland
Coloscopy
2.2
8.8
109
599
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
8.8
133
795
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.3
8.6
22
37
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
8.5
100
535
L04AX01
ATC
azathioprine; systemic
4.5
8.4
29
69
J01DB01
ATC
cefalexin; oral
2.1
8.0
299
2475
ZXA05
NOMESCO Finland
Left side
2.1
8.0
108
610
A46
ICD-10 Finland
Erysipelas
2.6
7.9
59
250
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
13.4
7.9
13
10
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.0
7.9
131
803
SPAT1255
SPAT
Intravenous administration of medicine
3.9
7.9
31
84
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.8
7.8
21
38
A02BA02
ATC
ranitidine; systemic
2.2
7.8
86
447
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.1
7.8
43
150
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.5
7.7
26
61
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.3
7.7
37
119
JAH00
NOMESCO Finland
Laparotomy
5.6
7.6
21
39
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
10.3
7.6
14
14
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
7.6
65
298
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
4.7
7.4
24
54
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.9
7.4
46
175
JN4BD
NOMESCO Finland
Extensive body CT
2.7
7.3
50
202
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
3.1
7.3
41
145
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.0
7.3
19
33
B01AA03
ATC
warfarin; systemic
2.2
7.3
84
443
UJF30
NOMESCO Finland
Ileoscopy through colon
2.8
7.2
45
172
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.1
7.1
38
132
N03AX16
ATC
pregabalin; oral
2.1
7.1
97
547
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.7
7.1
49
200
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
6.5
7.0
17
27
A06AD11
ATC
lactulose; oral
2.3
7.0
66
316
B01AB05
ATC
enoxaparin; parenteral
2.0
7.0
114
689
GD1AD
NOMESCO Finland
Thorax CT examination
4.6
7.0
23
53
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.6
6.8
29
85
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
6.6
70
353
N02AA05
ATC
oxycodone; systemic
2.3
6.6
64
311
A07AA02
ATC
nystatin; oral
3.4
6.6
31
98
J01CF02
ATC
cloxacillin; systemic
6.4
6.5
16
26
K59.09
ICD-10 Finland
Constipation, unspecified
3.2
6.5
33
111
X58
ICD-10 Finland
Exposure to other specified factors
2.4
6.5
54
245
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
5.1
6.4
19
39
WX110
NOMESCO Finland
Local anesthesy
1.8
6.4
244
1934
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
4.3
6.4
22
53
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.5
6.4
28
84
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.1
6.3
33
113
AA1AD
NOMESCO Finland
CT of head and brain
2.0
6.3
90
514
6BA02
NOMESCO Finland
NA
18.4
6.3
9
5
JAK03
NOMESCO Finland
Laparotomy and peritoneal irrigation
+∞
6.3
6
*
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
6.3
6
*
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
6.3
6
*
JAH33
NOMESCO Finland
Opening of laparostomy
+∞
6.3
6
*
NHW10
NOMESCO Finland
Reoperation for deep infection in in surgery of ankle or foot
+∞
6.3
6
*
D81.6
ICD-10 Finland
Major histocompatibility complex class I deficiency
+∞
6.3
6
*
J01XX08
ATC
linezolid; systemic
27.2
6.2
8
*
QDA10
NOMESCO Finland
Incision of skin of lower limb
27.2
6.2
8
*
ZX120
NOMESCO Finland
Intravenous
2.6
6.2
44
182
WX892
NOMESCO Finland
Monitored bed care
3.0
6.2
35
124
L28
ICPC
Limited function/disability (L)
2.2
6.2
63
312
JAH01
NOMESCO Finland
Laparoscopy
3.7
6.1
25
71
TDM10
NOMESCO Finland
Puncture of maxillary antrum
4.3
6.1
21
51
J04AB02
ATC
rifampicin; systemic
10.3
6.1
11
11
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.7
6.1
19
42
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.0
6.0
81
451
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
6.0
55
258
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.8
6.0
24
67
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
23
16
15.20
25.55
3.6
2.1
12.8
10.3
%
—
17
10
22
16
14.50
23.83
3.7
2.1
—
—
—
0
0
22
21
11.03
20.17
3.7
1.8
566.3
599.0
e6/l
0.06
17
16
146
754
2.48
15.94
3.4
2.2
3.0
3.1
mg/l
0.09
130
650
27
45
6.36
15.80
8.6
5.5
1262.0
200.0
iu/ml
—
5
7
98
476
2.41
11.78
3.0
2.2
12.2
13.1
umol/l
0.45
89
435
204
1334
2.09
11.65
8.0
4.5
34.6
35.5
g/l
1.51
195
1244
212
1407
2.09
11.62
12.3
6.0
1.2
1.2
mmol/l
0.02
191
1281
16
8
20.76
11.22
5.2
1.3
656.0
790.9
u/ml
—
16
8
90
430
2.41
11.17
3.0
2.2
2.4
2.3
g/l
0.49
82
396
49
178
3.00
10.41
1.5
1.4
—
—
—
0
0
221
1533
2.00
10.25
13.7
6.4
1.2
1.2
mmol/l
0.18
184
1293
85
412
2.35
10.14
3.6
2.3
20.3
22.4
%
0.62
74
359
26
64
4.28
9.86
3.0
1.2
11.0
10.6
mg/l
0.11
26
57
91
468
2.23
9.39
3.1
1.9
—
—
—
0
0
183
1230
1.90
8.92
2.3
2.0
93.6
95.2
pmol/l
0.15
109
616
53
218
2.65
8.92
2.3
1.5
—
—
—
0
0
106
594
2.07
8.72
4.6
3.4
188.9
359.7
ng/l
0.50
80
459
14
22
6.56
8.58
2.4
1.4
15.1
11.9
u/l
0.73
14
22
79
401
2.21
8.35
10.0
4.9
1.0
1.0
mmol/l
0.06
71
365
68
326
2.31
8.23
2.6
1.8
—
—
—
0
0
24
65
3.87
8.02
2.6
1.5
—
—
—
0
0
24
65
3.87
8.02
2.6
1.5
—
—
—
0
0
29
90
3.40
7.96
3.0
2.9
—
—
—
0
0
222
1626
1.83
7.92
9.4
5.6
10.1
12.0
umol/l
2.16
211
1547
88
481
2.07
7.65
6.3
3.2
0.8
0.8
mmol/l
0.75
80
455
239
1802
1.82
7.64
16.8
8.7
4.6
4.1
e9/l
2.38
216
1568
52
232
2.43
7.38
4.7
3.4
96.0
79.9
ng/l
0.64
46
208
20
52
4.00
7.07
1.6
1.4
—
—
—
0
0
65
332
2.15
6.70
2.7
1.9
—
—
—
0
0
18
45
4.14
6.69
2.4
1.6
—
—
—
0
0
188
1369
1.71
6.36
4.3
2.6
152.6
115.2
ug/l
1.14
176
1261
67
360
2.04
6.03
4.4
2.5
4.9
8.2
umol/l
2.76
59
311
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
24
79
3.17
6.03
5.1
2.5
0.3
0.3
u/ml
0.09
15
39
140
962
1.70
5.72
4.1
2.3
56.1
55.9
u/l
0.01
134
888
42
192
2.33
5.64
8.3
3.6
2.0
1.8
mmol/l
0.12
32
144
289
2408
1.74
5.57
14.7
6.8
83.1
79.5
u/l
0.70
276
2245
13
29
4.60
5.55
2.5
1.6
—
—
—
0
0
62
334
2.01
5.53
11.4
8.8
1.9
1.1
mmol/l
0.95
53
266
41
191
2.28
5.28
1.7
1.2
222.6
316.2
u/ml
0.24
35
171
157
1132
1.64
5.24
5.2
3.2
—
—
—
0
0
94
591
1.77
5.21
1.9
1.7
1238.7
1224.0
nmol/l
0.04
68
440
127
871
1.67
5.14
4.4
3.1
0.2
0.5
e6/l
2.31
107
662
24
88
2.84
5.04
1.8
1.2
—
—
—
0
0
172
1286
1.60
4.86
3.8
2.2
78.8
76.8
nmol/l
0.38
154
1147
45
226
2.12
4.83
3.1
2.6
154.4
190.5
ng/l
0.35
40
206
11
24
4.69
4.81
2.5
1.4
—
—
—
0
0
22
79
2.89
4.79
2.5
1.6
—
—
—
0
0
60
336
1.93
4.78
11.7
8.7
5.3
5.1
kpa
1.26
55
320
60
336
1.93
4.78
11.6
8.7
12.0
12.1
kpa
0.05
55
323
14
38
3.78
4.68
2.6
1.4
—
—
—
0
0
228
1836
1.57
4.58
9.8
4.8
7.0
6.6
mmol/l
1.03
221
1708
20
70
2.96
4.56
1.5
2.1
130.2
128.0
g/l
0.10
13
48
24
94
2.65
4.47
1.8
1.3
296.5
300.6
ug/g
0.04
17
58
50
270
1.97
4.43
13.8
4.1
1.9
2.1
mmol/l
0.11
35
215
13
35
3.81
4.40
3.4
1.5
—
—
—
0
0
10
22
4.64
4.32
1.8
1.4
—
—
—
0
0
52
289
1.92
4.24
4.3
1.8
324.7
383.4
nmol/l
1.38
47
261
15
46
3.35
4.23
5.0
2.4
4.9
5.0
e9/l
0.08
15
46
79
500
1.72
4.22
2.7
2.8
0.7
1.1
e6/l
1.11
43
284
18
62
2.99
4.22
1.9
1.4
—
—
—
0
0
36
176
2.15
4.15
2.2
1.8
—
—
—
0
0
274
2327
1.57
4.15
7.3
4.0
16.2
12.0
mm/h
4.42
259
2140
25
104
2.50
4.15
2.8
1.2
39.5
36.2
u/l
0.30
25
91
7
7
10.15
4.02
1.1
1.0
—
—
—
0
0
7
7
10.15
4.02
1.1
1.0
95.4
93.9
%
—
7
7
15
48
3.21
3.97
6.3
2.8
63.1
59.1
%
0.51
15
48
128
931
1.55
3.90
2.4
2.0
185.5
193.2
u/l
0.04
118
878
24
102
2.44
3.82
2.3
2.0
181.6
312.6
ug/l
0.76
24
95
6
5
12.15
3.77
3.2
1.8
—
—
—
0
0
46
257
1.89
3.70
3.2
2.3
3.3
6.6
ug/l
2.33
38
228
25
110
2.36
3.70
1.7
1.7
—
—
—
0
0
19
73
2.68
3.69
1.3
1.5
0.1
0.1
iu/ml
—
6
15
137
1023
1.52
3.67
5.0
2.9
37.9
31.3
u/l
1.02
132
979
104
734
1.56
3.58
1.8
1.6
18.8
21.2
nmol/l
1.16
94
611
47
268
1.85
3.56
16.6
7.3
1.2
1.3
mmol/l
0.69
42
252
50
291
1.82
3.55
3.2
2.2
37.2
28.7
u/l
0.53
45
241
9
17
5.39
3.53
2.4
6.8
—
63.0
—
0
5
6
6
10.13
3.51
2.0
1.0
—
—
—
0
0
96
669
1.57
3.49
2.6
1.8
1.3
1.2
mg/l
0.16
75
528
73
479
1.64
3.39
3.3
3.1
2.9
2.8
e6/l
0.04
38
265
12
37
3.31
3.37
1.1
1.3
—
—
—
0
0
26
122
2.21
3.34
1.9
2.1
1.8
1.5
g/l
0.61
21
107
13
44
3.02
3.16
3.4
1.4
—
—
—
0
0
14
50
2.87
3.12
3.3
1.5
—
—
—
0
0
122
916
1.48
3.10
4.5
3.7
19.2
8.4
mg/mmol
1.11
76
572
11
34
3.30
3.08
1.4
1.0
—
—
—
0
0
98
705
1.52
3.06
1.3
1.3
1.0
1.5
u/ml
0.48
28
203
179
1449
1.43
3.05
7.0
3.9
—
—
—
0
0
35
191
1.91
3.04
2.9
2.5
10.5
12.5
nmol/l
0.77
30
173
7
12
5.92
3.03
7.9
3.2
21.4
31.9
umol/l
—
7
12
104
763
1.49
2.95
4.7
2.4
346.1
5781.9
umol/l
2.61
92
649
13
46
2.89
2.94
1.4
1.2
—
—
—
0
0
9
22
4.16
2.90
2.3
3.0
—
—
—
0
0
120
910
1.46
2.87
3.9
3.0
1853.2
1341.6
ng/l
0.65
108
773
8
18
4.51
2.81
1.5
1.4
—
—
—
0
0
8
18
4.51
2.81
1.5
1.4
—
—
—
0
0
41
242
1.77
2.80
4.5
3.8
1.2
1.2
mmol/l
0.88
36
216
16
66
2.48
2.74
2.9
2.2
16.3
15.7
%
—
9
30
190
1575
1.40
2.74
4.7
3.6
0.0
0.0
estimate
0.50
39
283
187
1549
1.39
2.69
4.8
3.6
0.0
0.0
estimate
0.00
38
293
9
24
3.81
2.68
1.9
2.1
—
—
—
0
0
10
32
3.18
2.66
1.3
1.2
67.2
58.0
u/l
—
5
23
50
317
1.66
2.66
5.0
3.4
—
—
—
0
0
7
16
4.43
2.48
1.6
1.3
—
—
—
0
0
7
16
4.43
2.48
1.6
1.3
—
—
—
0
0
7
17
4.17
2.37
1.1
3.8
90.3
100.4
%
—
7
17
99
750
1.43
2.34
3.6
2.1
—
—
—
0
0
185
1555
1.36
2.33
6.0
4.9
0.0
0.0
estimate
0.00
38
292
21
106
2.04
2.30
3.3
1.7
—
—
—
0
0
17
79
2.20
2.28
1.3
1.2
—
—
—
0
0
7
18
3.94
2.26
2.0
1.4
—
—
—
0
0
10
37
2.75
2.12
1.5
1.1
1.5
1.4
g/l
—
10
31
8
25
3.24
2.10
1.4
1.1
—
—
—
0
0
8
25
3.24
2.10
2.5
1.6
—
—
—
0
0
284
3074
0.73
2.02
4.8
4.4
1.4
1.5
mmol/l
2.55
255
2827
13
57
2.32
2.00
1.4
1.2
—
—
—
0
0
8
27
3.00
1.94
2.5
1.6
—
—
—
0
0
14
65
2.20
1.90
1.8
1.3
—
—
—
0
0
19
100
1.95
1.89
1.4
1.1
—
—
—
0
0
21
115
1.87
1.86
3.4
1.8
—
—
—
0
0
287
3090
0.74
1.85
4.8
4.4
4.5
4.7
mmol/l
3.07
263
2862
131
1076
1.32
1.84
4.7
3.2
2.4
2.4
mmol/l
1.01
117
937
294
3152
0.74
1.81
5.3
4.9
2.6
2.8
mmol/l
2.46
265
2895
8
29
2.79
1.80
1.0
1.2
—
79.0
—
0
6
19
102
1.91
1.79
1.4
1.1
—
—
—
0
0
6
18
3.37
1.75
1.3
1.1
—
—
—
0
0
9
36
2.53
1.75
2.1
1.4
—
—
—
0
0
7
24
2.95
1.73
3.9
1.5
—
—
—
0
0
6
19
3.19
1.66
1.0
1.1
—
—
—
0
0
14
69
2.07
1.66
1.9
1.4
—
—
—
0
0
10
43
2.36
1.61
1.8
1.4
0.2
0.4
nmol/l
—
10
35
275
2961
0.77
1.61
4.1
3.9
1.5
1.3
mmol/l
4.08
248
2708
8
33
2.45
1.54
5.8
4.8
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
15
3.36
1.53
1.2
2.9
140.0
127.3
%
—
5
15
5
15
3.36
1.53
4.2
1.5
—
—
—
0
0
12
58
2.10
1.50
1.5
1.4
—
—
—
0
0
12
58
2.10
1.50
1.5
1.4
—
—
—
0
0
9
37
2.46
1.49
2.1
1.5
—
—
—
0
0
9
37
2.46
1.49
2.1
1.5
—
—
—
0
0
9
37
2.46
1.49
1.4
2.3
23.8
15.1
ug/l
—
9
37
9
37
2.46
1.49
2.1
1.5
—
—
—
0
0
20
117
1.75
1.48
3.3
2.0
3.0
3.0
g/l
0.02
14
96
9
38
2.40
1.46
2.1
1.4
—
—
—
0
0
9
38
2.40
1.46
2.1
1.4
—
—
—
0
0
82
651
1.33
1.44
1.8
1.7
436.9
7246824.4
pmol/l
0.50
67
552
5
16
3.15
1.44
4.2
1.5
—
—
—
0
0
21
126
1.70
1.43
3.1
1.9
7.6
7.5
g/l
0.07
14
99
21
126
1.70
1.43
3.1
1.9
—
—
—
0
0
21
126
1.70
1.43
3.1
1.9
3.2
3.8
g/l
1.40
14
94
265
2437
1.26
1.39
4.7
3.9
14.7
14.7
pmol/l
0.05
244
2210
5
17
2.96
1.36
1.0
3.3
58.2
88.7
nmol/l
—
5
17
16
90
1.81
1.35
5.6
4.5
24.1
26.4
mg/l
0.17
11
70
139
1195
1.25
1.31
5.6
3.6
26.6
40.7
ng/l
1.32
100
817
6
24
2.52
1.31
1.8
1.6
—
—
—
0
0
6
24
2.52
1.31
1.8
1.3
230.7
270.4
u/l
—
6
24
6
24
2.52
1.31
1.8
1.6
—
—
—
0
0
6
24
2.52
1.31
1.8
1.6
—
—
—
0
0
5
18
2.80
1.29
4.2
1.6
—
—
—
0
0
68
536
1.32
1.26
1.4
1.3
47.4
35.7
iu/ml
0.21
33
168
13
70
1.89
1.25
1.5
1.7
—
—
—
0
0
18
286
0.61
1.23
1.7
1.7
—
—
—
0
0
16
93
1.75
1.23
1.8
1.5
341.6
294.1
mu/l
0.42
16
85
5
20
2.52
1.15
1.8
2.0
—
—
—
0
0
10
51
1.99
1.12
1.2
1.1
—
—
—
0
0
5
21
2.40
1.09
1.2
1.3
—
—
—
0
0
5
21
2.40
1.09
1.4
1.2
—
—
—
0
0
215
1968
1.20
1.04
3.5
3.0
—
—
—
0
0
5
23
2.19
0.98
6.4
1.9
—
—
—
0
0
7
36
1.96
0.97
2.9
2.4
14.2
13.4
%
—
7
36
49
386
1.31
0.94
13.2
6.6
—
—
—
0
0
24
168
1.46
0.92
1.4
1.3
—
—
—
0
0
5
102
0.48
0.90
1.2
1.9
—
—
—
0
0
328
3153
1.23
0.83
31.7
13.6
26.7
23.2
mg/l
1.11
290
2476
42
334
1.29
0.77
4.3
3.8
3.5
40.1
ug/l
0.95
32
287
7
40
1.76
0.71
3.7
1.5
—
—
—
0
0
5
26
1.93
0.71
1.2
1.0
—
—
—
0
0
15
103
1.47
0.66
2.3
1.6
—
—
—
0
0
302
2902
1.17
0.65
6.0
4.7
2.0
2.3
mu/l
0.24
278
2638
5
29
1.73
0.64
1.2
1.1
—
—
—
0
0
5
29
1.73
0.64
1.2
1.1
—
—
—
0
0
5
30
1.67
0.61
1.2
1.1
—
—
—
0
0
5
30
1.67
0.61
1.2
1.1
—
—
—
0
0
5
30
1.67
0.61
1.2
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
276
2643
1.15
0.59
34.7
17.1
14.1
13.7
%
4.75
271
2595
0
23
0.00
0.58
0.0
1.0
—
33.1
—
0
12
0
23
0.00
0.58
0.0
1.0
—
542.8
—
0
12
334
3245
1.18
0.58
33.8
15.8
4.0
4.0
mmol/l
0.38
328
3154
333
3239
1.17
0.54
33.7
15.7
139.4
139.7
mmol/l
1.15
326
3153
94
845
1.15
0.53
1.8
1.7
1.4
1.4
mmol/l
0.20
75
722
296
3052
0.88
0.48
5.4
4.5
6.0
5.9
mmol/l
0.58
271
2799
42
492
0.84
0.48
2.7
3.0
1.2
0.7
ug/l
0.31
30
311
7
47
1.50
0.48
1.3
1.1
—
—
—
0
0
289
2980
0.89
0.45
23.8
12.7
81.7
80.4
ml/min/173m2
0.42
258
2435
131
1219
1.11
0.42
5.4
3.8
—
—
—
0
0
216
2064
1.10
0.41
4.5
3.0
61.7
46.2
u/l
2.09
196
1940
0
15
0.00
0.41
0.0
1.0
—
1.2
—
0
9
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
344
3503
0.87
0.40
41.7
20.1
129.2
134.6
g/l
7.74
339
3446
29
243
1.21
0.39
2.9
2.6
54.8
64.1
ml/min/173m2
0.60
13
100
283
2910
0.90
0.38
6.7
5.5
41.2
39.6
mmol/mol
1.70
269
2706
5
37
1.36
0.37
2.0
3.2
2.5
3.2
nmol/l
—
5
37
9
70
1.29
0.37
1.3
1.9
—
—
—
0
0
46
519
0.87
0.35
1.8
1.4
—
—
—
0
0
67
607
1.12
0.35
4.0
2.7
2.5
2.5
mmol/l
1.37
55
533
58
523
1.13
0.33
1.4
1.3
18.1
12.0
u/ml
0.17
19
204
21
252
0.82
0.33
2.0
1.9
—
—
—
0
0
34
390
0.86
0.33
6.0
4.4
32.2
31.9
%
0.06
24
256
331
3362
0.91
0.27
19.0
9.7
27.0
25.0
u/l
1.61
322
3243
62
673
0.91
0.26
4.7
4.4
20.0
20.4
%
0.07
30
306
92
864
1.08
0.25
6.8
4.0
0.0
0.0
estimate
0.00
39
287
12
96
1.26
0.25
1.2
1.1
—
9.2
—
0
12
5
39
1.29
0.23
1.4
1.4
—
—
—
0
0
5
40
1.25
0.22
4.8
2.9
26.3
54.8
u/ml
—
5
40
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
5
43
1.16
0.21
1.2
1.7
—
—
—
0
0
291
2859
1.07
0.20
30.7
14.9
38.7
39.8
%
1.27
200
2118
6
49
1.23
0.20
1.7
1.3
7.8
7.8
mmol/l
—
6
30
6
52
1.16
0.19
1.2
1.5
—
—
—
0
0
6
53
1.13
0.18
1.3
1.2
723.9
16.1
u/l
—
6
47
18
157
1.15
0.17
1.0
1.0
—
—
—
0
0
81
849
0.94
0.16
5.3
5.0
4.8
3.2
ug/l
0.39
70
756
13
111
1.18
0.16
1.2
1.4
—
—
—
0
0
26
282
0.92
0.12
2.0
2.0
—
—
—
0
0
10
87
1.15
0.09
2.2
1.2
—
—
—
0
0
14
155
0.90
0.09
1.7
2.1
—
—
—
0
0
8
78
1.03
0.07
1.3
1.3
—
—
—
0
0
7
80
0.87
0.07
1.0
1.1
—
—
—
0
0
11
118
0.93
0.03
1.7
2.1
—
—
—
0
0
10
107
0.93
0.02
1.3
1.5
—
—
—
0
0
54
534
1.01
0.00
1.6
1.5
—
—
—
0
0
22
225
0.98
0.00
1.4
1.2
45.5
169.1
iu/ml
—
10
91
10
104
0.96
0.00
1.4
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
49
1.02
0.00
2.0
1.5
35.4
29.4
u/l
—
5
42
5
59
0.85
0.00
1.4
1.4
—
—
—
0
0
5
59
0.85
0.00
1.4
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
5
59
0.85
0.00
1.4
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
1.0
1.1
—
1.7
—
0
21
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
84.3
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint D3_COMBIMMUDEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_COMBIMMUDEF | 1.981 [1.72, 2.29] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.207 |
During the follow-up period (1.1.1998 — 31.12.2019), 454 out of 1489 females with D3_COMBIMMUDEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_COMBIMMUDEF | 2.256 [1.92, 2.65] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 516 out of 1183 males with D3_COMBIMMUDEF died.
Mortality risk
Mortality risk for people of age
years, who have D3_COMBIMMUDEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.171% | 0.394% |
| 5 | 1.141% | 2.075% |
| 10 | 2.912% | 5.699% |
| 15 | 5.574% | 11.202% |
| 20 | 9.77% | 18.871% |
Relationships between endpoints
↥Index endpoint: D3_COMBIMMUDEF – Combined immunodeficiencies
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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