femoral neuropathy: Neuropathy of the femoral nerve.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
275 |
4. Check minimum number of eventsNone |
275 |
5. Include endpointsNone |
275 |
6. Filter based on genotype QC (FinnGen only) |
275 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G57
- Name in latin
- Morbositas nervi femoralis
Similar endpoints
↥List of similar endpoints to
Lesion of femoral nerve
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1898 | 1197 | 693 |
| Only index persons | 1739 | 1132 | 607 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.04 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 52.40 | 52.31 | 52.41 |
| Only index persons | 51.40 | 51.82 | 50.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 275 | 203 | 72 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.03 |
| Median age at first event (years) | 49.80 | 49.79 | 49.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 252
- Matched controls
- 2519
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G57.2
ICD-10 Finland
Lesion of femoral nerve
+∞
323.0
237
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
8.0
35.9
92
168
N03AX16
ATC
pregabalin; oral
5.6
30.7
110
304
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
104.5
26.2
28
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
17.5
24.7
39
26
N03AX12
ATC
gabapentin; oral
5.7
24.1
79
188
N02AX02
ATC
tramadol; systemic, rectal
4.0
24.1
152
693
M54.4
ICD-10 Finland
Lumbago with sciatica
5.1
22.2
80
210
M54.5
ICD-10 Finland
Low back pain
3.6
19.6
121
511
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
5.8
18.9
57
120
G57.1
ICD-10 Finland
Meralgia paraesthetica
35.9
18.3
23
7
M48.0
ICD-10 Finland
Spinal stenosis
5.2
17.2
58
138
N06AA09
ATC
amitriptyline; systemic
5.3
16.5
54
124
N06AX21
ATC
duloxetine; oral
5.2
15.5
51
117
XA402
NOMESCO Finland
ENMG
13.0
15.0
26
22
3552A
ICD-9 Finland
Mononeuritis of lower limb, Other lesion of femoral nerve
+∞
14.7
14
*
M79.6
ICD-10 Finland
Pain in limb
3.0
14.6
122
607
M01AX17
ATC
nimesulide; oral
3.1
13.4
91
389
M70.6
ICD-10 Finland
Trochanteric bursitis
3.8
13.0
60
191
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.8
12.8
115
585
L86
ICPC
Back syndrome with radiating pain
6.5
12.6
33
57
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.5
12.5
64
222
M03BX02
ATC
tizanidine; oral
2.8
12.4
184
1244
L13
ICPC
Hip symptom/complaint
3.5
12.1
64
225
G57.0
ICD-10 Finland
Lesion of sciatic nerve
+∞
11.5
11
*
ACC51
NOMESCO Finland
Release of median nerve
125.5
11.5
12
*
L03
ICPC
Low back symptom/complaint
3.0
11.5
81
348
M54.1
ICD-10 Finland
Radiculopathy
8.3
11.5
25
33
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
5.5
11.1
33
67
M03BC51
ATC
orphenadrine, combinations; systemic
2.6
10.4
95
474
M25.5
ICD-10 Finland
Pain in joint
2.6
10.3
91
443
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.8
10.1
79
357
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.5
10.1
96
490
M54.9
ICD-10 Finland
Dorsalgia, unspecified
3.6
9.7
45
143
G57.8
ICD-10 Finland
Other mononeuropathies of lower limb
+∞
9.4
9
*
M54.3
ICD-10 Finland
Sciatica
5.6
9.1
26
51
L02
ICPC
Back symptom/complaint
3.9
8.9
37
107
G54.0
ICD-10 Finland
Brachial plexus disorders
51.8
8.7
10
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.2
8.7
33
88
M53.1
ICD-10 Finland
Cervicobrachial syndrome
3.5
8.5
40
128
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.9
8.4
34
96
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
15.1
8.3
13
9
A02BC05
ATC
esomeprazole; systemic
2.2
8.3
117
710
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
7.2
8.2
19
28
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.4
8.2
87
461
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
34.5
8.1
10
*
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
5.5
8.1
23
45
M01AB05
ATC
diclofenac; systemic, rectal
2.2
8.1
181
1339
G57.6
ICD-10 Finland
Lesion of plantar nerve
13.6
8.0
13
10
M01AE03
ATC
ketoprofen; systemic, rectal
2.2
8.0
108
639
L01
ICPC
Neck symptom/complaint
2.9
7.8
48
186
SPAT1130
SPAT
Esophagoscopy, gastroscopy and duodenoscopy
6.5
7.7
19
31
M03BC01
ATC
orphenadrine (citrate); systemic
2.4
7.7
77
394
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
19.1
7.7
11
6
SPAT1216
SPAT
Assessment of functional ability
2.9
7.6
48
189
R52.9
ICD-10 Finland
Pain, unspecified
3.6
7.6
34
105
M79.7
ICD-10 Finland
Fibromyalgia
8.1
7.5
16
21
M47.82
ICD-10 Finland
Other spondylosis, cervical region
5.3
7.5
22
45
N02AA05
ATC
oxycodone; systemic
2.9
7.5
46
178
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
5.0
7.4
23
50
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
6.1
7.4
19
33
M01AH01
ATC
celecoxib; oral (coxibs)
2.5
7.4
60
275
A02BC03
ATC
lansoprazole; oral
2.2
7.4
89
497
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
20.7
7.2
10
5
N06AX11
ATC
mirtazapine; oral
2.2
7.1
95
550
N02BE01
ATC
paracetamol; systemic, rectal
2.7
7.1
223
1868
N03AE01
ATC
clonazepam; systemic
4.5
7.0
24
58
SPAT1249
SPAT
Treatment-related counselling outside office
2.1
7.0
113
710
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.9
7.0
28
79
A02BA02
ATC
ranitidine; systemic
2.5
6.9
61
289
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
11.4
6.9
12
11
A02BC02
ATC
pantoprazole; systemic
2.1
6.9
175
1317
RD211
NOMESCO Finland
NA
4.5
6.8
23
55
L14
ICPC
Leg/thigh symptom/complaint
3.8
6.8
28
81
L17
ICPC
Foot/toe symptom/complaint
2.3
6.7
74
390
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
2.0
6.7
131
883
SPAT1310
SPAT
Counselling related to known health issue
2.1
6.6
93
549
L08
ICPC
Shoulder symptom/complaint
2.5
6.5
57
268
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
5.2
6.5
19
39
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
14.8
6.4
10
7
J01AA02
ATC
doxycycline; systemic
2.3
6.4
209
1716
M01AH05
ATC
etoricoxib; oral
2.0
6.4
160
1178
RF420
NOMESCO Finland
NA
9.6
6.4
12
13
M01AC06
ATC
meloxicam; systemic, rectal
2.0
6.3
107
680
35399
ICD-8 Finland
Sciatica
+∞
6.3
6
*
G58.9
ICD-10 Finland
Mononeuropathy, unspecified
+∞
6.3
6
*
WX110
NOMESCO Finland
Local anesthesy
2.0
6.1
175
1344
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
10.4
6.1
11
11
N05CF01
ATC
zopiclone; oral
2.0
6.1
93
565
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.9
6.0
35
131
Mortality – FinRegistry
↥Association
Association between endpoint G6_FEMLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_FEMLE | 0.953 [0.78, 1.16] | 0.637 |
| Birth year | 0.996 [0.99, 1.0] | 0.355 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 1038 females with G6_FEMLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_FEMLE | 1.514 [1.24, 1.85] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 147 out of 596 males with G6_FEMLE died.
Mortality risk
Mortality risk for people of age
years, who have G6_FEMLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | 0.246% |
| 5 | 0.603% | 1.748% |
| 10 | 1.412% | 4.45% |
| 15 | 2.804% | 8.239% |
| 20 | 5.006% | 13.697% |
Relationships between endpoints
↥Index endpoint: G6_FEMLE – Lesion of femoral nerve
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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