brain disease: A disease affecting the brain or part of the brain.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
207 |
4. Check minimum number of eventsNone |
207 |
5. Include endpointsNone |
207 |
6. Filter based on genotype QC (FinnGen only) |
205 |
Control definitions (FinnGen only)
- Control exclude
- G6_HYDROCEPH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Hydrocephalus in other diseases
based on the number of shared cases.
Similar with more cases:
- Hydrocephalus
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1769 | 924 | 839 |
| Only index persons | 1488 | 795 | 693 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 56.83 | 58.92 | 54.41 |
| Only index persons | 57.38 | 58.88 | 55.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 205 | 131 | 74 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | 60.76 | 60.02 | 62.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 207
- Matched controls
- 2070
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
138.6
117
*
AAF00
NOMESCO Finland
Ventriculostomy
+∞
127.7
109
*
AA1AD
NOMESCO Finland
CT of head and brain
17.3
89.0
160
340
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
56.5
82.6
48
11
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
12.0
74.0
112
185
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
13.1
66.2
78
91
G94.2
ICD-10 Finland
Hydrocephalus in other diseases classified elsewhere
+∞
53.5
49
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
25.1
52.6
39
19
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
10.2
52.1
73
105
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
47.8
44
*
N03AX14
ATC
levetiracetam; systemic
21.2
46.6
37
21
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
114.4
42.8
45
5
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
42.1
39
*
WX872
NOMESCO Finland
Intensive care
13.3
41.4
43
40
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
35.4
33
*
PA2AD
NOMESCO Finland
CT angiography of brain
92.2
35.2
38
5
ZXD05
NOMESCO Finland
Urgent procedure
5.7
35.2
122
414
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
15.0
33.9
32
25
AA5PD
NOMESCO Finland
CT examination of brain pefusion
139.6
33.8
35
*
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
195.1
32.7
33
*
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
51.2
32.2
38
9
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
+∞
32.1
30
*
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
32.1
30
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
5.2
30.3
94
284
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
29.9
28
*
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
94.2
29.7
32
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.5
29.6
77
200
PA3AC
NOMESCO Finland
Carotis angiography with X-ray
90.3
28.6
31
*
PA4AC
NOMESCO Finland
Vertebralis angiography with X-ray
+∞
27.7
26
*
WX730
NOMESCO Finland
Conventional respirator
69.7
26.8
30
5
G942, I602,
ICD-10 Finland
+∞
26.6
25
*
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
+∞
25.5
24
*
K90
ICPC
Stroke/cerebrovascular accident
32.4
25.4
33
12
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
38.7
24.1
30
9
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
8.2
22.3
32
45
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
21.2
20
*
I61.5
ICD-10 Finland
Intracerebral haemorrhage, intraventricular
+∞
20.1
19
*
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
61.1
19.3
22
*
AAF50
NOMESCO Finland
Third ventriculostomy
+∞
18.0
17
*
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
20.7
16.5
24
13
SPAT1215
SPAT
Assessment of need for medical rehabilitation
8.0
16.0
23
32
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
21.4
16.0
23
12
G91.8
ICD-10 Finland
Other hydrocephalus
+∞
15.8
15
*
G94.1
ICD-10 Finland
Hydrocephalus in neoplastic disease
+∞
15.8
15
*
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
172.5
15.7
16
*
AA1AA
NOMESCO Finland
Head X-ray examination
31.4
15.5
20
7
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
22.2
15.5
22
11
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
12.2
15.0
27
25
SPAT1229
SPAT
Assessment of need for aid
5.4
14.8
32
68
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
14.9
14.6
24
18
PA2KT
NOMESCO Finland
Endovascular closure of brain aneurysm
46.1
14.3
17
*
G97.2
ICD-10 Finland
Intracranial hypotension following ventricular shunting
+∞
13.7
13
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
23.1
13.6
19
9
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
23.1
13.6
19
9
R51.80
ICD-10 Finland
Headache
3.4
13.2
58
210
N18
ICPC
Paralysis/weakness
15.4
13.1
21
15
Z51.5
ICD-10 Finland
Palliative care
4.8
13.0
32
76
XX3DW
NOMESCO Finland
Time consuming IT work
3.7
13.0
48
155
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
26.3
12.7
17
7
I60.7
ICD-10 Finland
Subarachnoid haemorrhage from intracranial artery, unspecified
+∞
12.6
12
*
H02AB02
ATC
dexamethasone; systemic
3.6
12.5
49
164
PA2YT
NOMESCO Finland
Cerebral artery PTA with stent
69.0
11.7
13
*
G942, I601,
ICD-10 Finland
+∞
11.6
11
*
G942, I615,
ICD-10 Finland
+∞
11.6
11
*
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
+∞
11.6
11
*
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
11.6
11
*
I60.6
ICD-10 Finland
Subarachnoid haemorrhage from other intracranial arteries
+∞
11.6
11
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
11.4
79
369
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
12.2
11.3
20
18
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
13.9
10.9
18
14
WX882
NOMESCO Finland
High dependency care
9.3
10.9
22
26
L28
ICPC
Limited function/disability (L)
3.1
10.5
53
206
PA2MT
NOMESCO Finland
Endovascular closure of very extensive brain aneurysm
115.6
10.5
11
*
NK6AI
NOMESCO Finland
Other cone beam scan
115.6
10.5
11
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.2
10.2
49
185
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
42.3
10.1
12
*
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
16.0
9.7
15
10
G942, I690,
ICD-10 Finland
+∞
9.4
9
*
G941, D431,
ICD-10 Finland
+∞
9.4
9
*
Z98.2
ICD-10 Finland
Presence of cerebrospinal fluid drainage device
+∞
9.4
9
*
ZXC86
NOMESCO Finland
Use of endoscopic device
38.5
9.1
11
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
13.4
9.0
15
12
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
25.3
9.0
12
5
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.6
8.8
31
96
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
12.3
8.7
15
13
PA7BD
NOMESCO Finland
CT angiography of neck and brain
12.3
8.7
15
13
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.5
8.6
81
429
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.7
8.6
29
87
XX1ZW
NOMESCO Finland
Very extensive written report from radiologist
28.9
8.6
11
*
N29
ICPC
Neurological sympt/complt other
13.5
8.5
14
11
I60.8
ICD-10 Finland
Other subarachnoid haemorrhage
93.7
8.5
9
*
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
10.1
8.4
16
17
G942, I609,
ICD-10 Finland
+∞
8.4
8
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
15.3
8.3
13
9
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.1
8.3
18
38
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
8.3
93
532
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.3
8.1
22
56
N03AF02
ATC
oxcarbazepine; oral
7.1
8.1
19
29
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.6
7.9
28
87
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.4
7.7
20
49
SPAT1216
SPAT
Assessment of functional ability
2.8
7.6
45
189
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
8.2
7.5
16
21
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.9
7.5
23
64
G40.10
ICD-10 Finland
Simple partial seizures
82.9
7.5
8
*
AAB30
NOMESCO Finland
Evacuation of spontaneous intracranial haematoma
82.9
7.5
8
*
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
82.9
7.5
8
*
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
82.9
7.5
8
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
8.9
7.5
15
18
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
9.9
7.4
14
15
D21
ICPC
Swallowing problem
11.5
7.4
13
12
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
11.5
7.4
13
12
I61.8
ICD-10 Finland
Other intracerebral haemorrhage
+∞
7.3
7
*
G942, I600,
ICD-10 Finland
+∞
7.3
7
*
N28
ICPC
Limited function/disability (N)
16.5
7.3
11
7
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.2
7.2
20
52
SPAT1231
SPAT
Assessment of adjustments needed in living environment
10.6
7.1
13
13
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.5
7.0
25
78
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
11.5
6.9
12
11
I60.3
ICD-10 Finland
Subarachnoid haemorrhage from posterior communicating artery
41.4
6.8
8
*
C71.90
ICD-10 Finland
Malignant tumor in unspecified localization in the brain without histology
41.4
6.8
8
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
6.3
6.8
17
29
WX402
NOMESCO Finland
General anaesthesia
2.4
6.8
55
269
JN4AD
NOMESCO Finland
Body CT examination
3.1
6.7
31
113
I63.8
ICD-10 Finland
Other cerebral infarction
23.4
6.7
9
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.9
6.6
33
126
U04
ICPC
Incontinence urine
4.3
6.5
17
42
SPAT1304
SPAT
Counselling and guidance related to ageing
3.6
6.5
22
66
ZXC95
NOMESCO Finland
Use of surgical navigator
11.5
6.4
11
10
N03AG01
ATC
valproic acid; systemic, rectal
3.6
6.3
22
67
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
7.4
6.3
14
20
R47.1
ICD-10 Finland
Dysarthria and anarthria
18.7
6.3
9
5
G941, C7931,
ICD-10 Finland
+∞
6.3
6
*
I60.4
ICD-10 Finland
Subarachnoid haemorrhage from basilar artery
+∞
6.3
6
*
AAA27
NOMESCO Finland
Insertion of intracerebral pressure monitoring device
+∞
6.3
6
*
G942, I606,
ICD-10 Finland
+∞
6.3
6
*
C79.31
ICD-10 Finland
Secondary malignant tumor of the cerebellum
27.6
6.3
8
*
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.6
6.2
41
181
XCK00
NOMESCO Finland
Perimetry
3.7
6.2
20
58
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.5
6.2
17
33
ZXD00
NOMESCO Finland
Emergency procedure
6.4
6.1
15
25
Z3231
NOMESCO Finland
Registered nurse
0.2
6.1
12
415
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
81
12
110.25
154.41
3.8
1.0
—
—
—
0
0
51
43
15.41
52.61
2.6
1.7
—
—
—
0
0
38
6
76.99
34.36
3.8
1.0
—
—
—
0
0
31
8
45.18
25.71
3.1
1.0
53.21
—
%
—
19
0
141
644
4.73
25.54
3.8
3.8
43.78
31.54
ng/l
0.36
114
453
154
781
4.80
23.48
8.4
11.9
1.06
1.21
inr
3.11
71
230
27
32
9.55
21.51
2.6
2.7
18.11
15.88
%
1.19
13
13
60
166
4.68
20.67
4.2
3.8
—
—
—
0
0
34
59
6.70
19.54
1.5
2.3
—
—
—
0
0
31
57
6.22
16.76
1.5
1.9
—
—
—
0
0
39
103
4.43
13.92
6.2
4.6
2.38
1.50
mmol/l
0.75
31
75
158
999
3.46
13.63
7.7
5.0
6.57
6.63
mmol/l
0.19
153
929
41
147
3.23
9.25
12.3
7.4
6.60
9.49
mmol/l
2.74
41
139
18
37
5.23
8.53
2.5
2.1
141.08
127.74
g/l
1.69
13
23
117
779
2.15
6.77
4.1
2.7
—
—
—
0
0
78
453
2.16
6.33
6.1
4.0
0.00
0.00
estimate
-0.00
41
161
52
255
2.39
6.32
2.0
1.9
—
—
—
0
0
6
0
+∞
6.28
5.7
0.0
0.07
—
ug/l
—
6
0
13
17
8.08
6.22
3.3
1.6
20.69
18.14
ug/l
0.11
13
17
17
34
5.35
6.03
1.8
3.4
29.35
36.78
umol/l
0.82
17
27
9
6
15.59
5.96
2.0
1.0
—
—
—
0
0
69
392
2.14
5.85
4.5
2.4
—
—
—
0
0
145
1108
2.03
5.13
7.3
4.3
181.60
233.61
e6/l
—
10
18
118
860
1.87
4.59
11.6
7.5
1.21
1.22
mmol/l
0.14
84
726
150
1743
0.49
4.58
4.7
5.1
2.68
2.78
mmol/l
0.64
131
1600
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
8
10.34
4.56
1.4
1.0
—
—
—
0
0
95
664
1.80
4.09
6.3
3.7
—
—
—
0
0
9
14
6.66
4.03
1.2
1.1
—
—
—
0
0
108
792
1.76
3.89
10.1
6.6
1.21
1.22
mmol/l
0.29
98
718
127
1532
0.56
3.88
26.4
16.8
15.76
15.12
%
0.47
127
1517
27
126
2.31
3.61
2.2
1.5
—
—
—
0
0
138
1617
0.56
3.58
6.6
5.7
40.05
39.98
mmol/mol
0.03
122
1497
149
1706
0.55
3.48
4.5
4.4
1.44
1.50
mmol/l
1.00
131
1564
12
34
3.68
3.25
2.0
1.5
—
—
—
0
0
69
471
1.70
3.06
2.9
3.2
668.66
1080.14
ng/l
1.67
61
392
56
361
1.76
3.04
1.4
1.9
505.39
466.24
pmol/l
0.29
44
291
152
1714
0.57
2.93
4.5
4.5
4.56
4.72
mmol/l
0.97
132
1582
10
27
3.84
2.92
1.2
1.7
—
—
—
0
0
10
27
3.84
2.92
1.2
1.7
—
—
—
0
0
10
27
3.84
2.92
1.2
1.7
—
—
—
0
0
10
27
3.84
2.92
1.1
1.6
—
—
—
0
0
10
27
3.84
2.92
1.2
1.7
—
—
—
0
0
9
22
4.23
2.91
1.4
1.2
—
—
—
0
0
13
47
2.88
2.87
2.5
1.9
—
—
—
0
0
11
33
3.46
2.86
1.5
2.0
—
—
—
0
0
11
33
3.46
2.86
1.5
2.0
—
—
—
0
0
10
28
3.70
2.82
1.2
1.6
—
—
—
0
0
19
85
2.36
2.80
1.3
1.6
—
—
—
0
0
14
54
2.71
2.76
2.4
2.5
—
—
—
0
0
11
35
3.26
2.69
4.2
2.6
4.28
4.92
e9/l
0.15
11
35
76
548
1.61
2.67
2.8
2.5
45.96
63.77
u/l
1.38
69
508
5
7
7.28
2.56
2.8
1.9
—
—
—
0
0
5
7
7.28
2.56
1.6
1.0
—
—
—
0
0
115
920
1.56
2.55
10.8
6.7
8.02
10.67
umol/l
5.24
109
878
11
37
3.08
2.53
6.2
3.1
51.55
60.27
%
1.04
11
37
19
90
2.22
2.47
1.9
1.3
—
—
—
0
0
106
839
1.54
2.43
6.1
3.7
0.00
0.00
estimate
-0.00
48
174
8
22
3.74
2.39
1.4
1.8
—
—
—
0
0
8
22
3.74
2.39
1.4
1.8
—
—
—
0
0
5
8
6.37
2.38
1.0
1.1
36.40
19.12
u/l
—
5
8
5
8
6.37
2.38
1.0
1.1
114.40
49.63
u/l
—
5
8
7
17
4.22
2.38
1.3
1.1
—
—
—
0
0
7
18
3.99
2.27
3.4
1.4
—
—
—
0
0
106
849
1.51
2.24
6.1
3.7
0.00
0.00
estimate
-0.00
45
159
8
24
3.42
2.20
2.9
1.5
—
—
—
0
0
105
842
1.50
2.19
7.6
5.0
0.00
0.00
estimate
-0.00
44
163
37
232
1.72
2.19
3.9
4.5
32.14
31.95
%
0.04
28
149
7
19
3.77
2.17
1.0
1.0
—
—
—
0
0
7
19
3.77
2.17
1.0
1.0
—
—
—
0
0
15
293
0.47
2.11
3.0
2.6
1.11
1.01
e6/l
—
10
166
171
1843
0.59
2.09
14.9
10.7
28.50
25.93
u/l
1.10
161
1775
5
10
5.09
2.08
6.2
3.0
—
—
—
0
0
6
15
4.09
2.05
1.0
1.0
—
—
—
0
0
11
44
2.58
2.05
1.6
1.3
—
—
—
0
0
7
21
3.41
1.98
1.7
2.1
—
—
—
0
0
79
612
1.47
1.89
5.4
3.0
—
—
—
0
0
5
12
4.24
1.83
1.2
1.3
—
—
—
0
0
11
47
2.42
1.81
1.4
1.5
—
—
—
0
0
182
1922
0.56
1.80
38.5
20.7
38.80
40.16
%
3.69
173
1821
6
18
3.40
1.76
1.0
1.4
—
0.31
nmol/l
—
0
11
7
24
2.98
1.74
10.7
4.6
228.71
79.99
u/ml
—
7
24
11
48
2.36
1.73
3.0
1.9
—
—
—
0
0
0
49
0.00
1.71
0.0
1.1
—
—
—
0
0
10
42
2.45
1.64
4.2
4.4
24.60
29.04
mg/l
—
5
26
8
32
2.56
1.61
3.6
1.9
—
—
—
0
0
34
486
0.64
1.58
1.8
1.7
1.32
1.38
mmol/l
0.23
24
408
150
1641
0.69
1.55
4.4
4.0
1.32
1.29
mmol/l
0.21
134
1493
6
21
2.91
1.51
1.7
2.1
—
—
—
0
0
21
331
0.59
1.47
1.7
1.5
—
—
—
0
0
51
382
1.44
1.41
2.1
1.8
1.12
1.28
mg/l
0.13
42
304
33
463
0.66
1.39
3.3
3.0
346.71
7323.72
umol/l
2.51
28
397
6
23
2.66
1.37
1.0
1.3
—
—
—
0
0
5
17
2.99
1.36
1.0
1.0
—
—
—
0
0
0
39
0.00
1.35
0.0
1.1
—
15.11
—
0
7
42
307
1.46
1.32
2.0
1.7
1350.59
1264.14
nmol/l
0.22
34
226
158
1700
0.70
1.30
4.3
4.6
6.04
5.93
mmol/l
0.42
133
1549
7
30
2.38
1.13
1.7
1.3
—
—
—
0
0
25
353
0.67
1.08
4.2
4.2
21.62
22.12
%
0.08
14
165
95
1086
0.77
1.08
2.7
3.0
—
—
—
0
0
5
22
2.30
1.04
1.6
1.2
—
—
—
0
0
126
1130
1.29
1.01
5.0
3.2
62.08
46.15
u/l
0.71
117
1061
8
47
1.73
0.81
2.0
1.4
—
—
—
0
0
23
309
0.71
0.78
1.3
1.3
1.40
12.48
u/ml
—
7
113
145
1346
1.26
0.77
11.0
7.7
84.53
81.43
u/l
0.23
135
1262
58
675
0.80
0.69
1.9
1.9
107.61
97.67
pmol/l
0.67
38
324
5
27
1.87
0.69
2.6
1.9
—
—
—
0
0
154
1623
0.80
0.67
5.2
4.7
1.75
2.69
mu/l
0.67
132
1467
64
733
0.82
0.65
3.7
2.7
167.65
114.89
ug/l
0.89
54
675
8
50
1.62
0.62
1.9
2.0
—
—
—
0
0
5
30
1.68
0.62
3.8
1.4
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
3.26
—
0
11
0
22
0.00
0.59
0.0
1.8
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
7.27
—
0
16
6
35
1.74
0.58
2.3
1.8
—
—
—
0
0
26
324
0.77
0.55
1.3
1.3
75.16
34.52
iu/ml
—
7
120
56
490
1.20
0.50
5.2
2.9
0.30
0.47
e6/l
0.62
51
367
34
404
0.81
0.49
1.3
1.3
0.81
1.78
u/ml
—
9
106
170
1636
1.22
0.47
21.9
13.2
86.37
81.00
ml/min/173m2
2.83
156
1329
7
48
1.47
0.47
1.7
1.8
—
—
—
0
0
81
737
1.16
0.45
7.7
4.6
33.16
35.84
g/l
3.07
72
702
7
50
1.41
0.45
1.0
1.2
—
—
—
0
0
26
315
0.80
0.45
3.1
3.3
1503.57
119.45
ng/l
0.45
14
242
8
56
1.45
0.43
1.4
1.4
—
—
—
0
0
5
33
1.53
0.41
2.6
1.8
—
—
—
0
0
126
1328
0.87
0.41
4.9
4.1
13.03
12.15
mm/h
0.25
113
1208
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
14
181
0.76
0.40
3.5
1.8
—
—
—
0
0
9
122
0.73
0.36
3.0
2.3
135.56
171.45
ng/l
—
9
111
66
602
1.14
0.35
3.7
3.4
2.35
2.36
mmol/l
0.26
58
530
78
724
1.12
0.32
2.7
2.4
79.22
76.99
nmol/l
0.23
70
646
18
214
0.83
0.27
1.9
6.8
—
—
—
0
0
17
141
1.22
0.27
1.5
2.2
7.72
5.07
ug/l
0.22
12
121
13
157
0.82
0.23
3.0
2.0
—
—
—
0
0
57
530
1.10
0.22
3.6
3.8
10.27
8.69
mg/mmol
0.10
34
324
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
2.5
—
793.54
—
0
13
0
13
0.00
0.21
0.0
1.0
—
494.00
—
0
8
0
13
0.00
0.21
0.0
1.0
—
42.50
—
0
8
15
175
0.85
0.19
22.4
9.9
4.98
5.17
kpa
0.78
15
168
15
175
0.85
0.19
22.4
9.9
16.32
12.23
kpa
0.96
15
168
177
1742
1.11
0.17
27.8
13.9
18.47
22.03
mg/l
0.86
162
1340
16
178
0.89
0.12
3.1
1.8
—
—
—
0
0
14
124
1.14
0.11
1.4
1.2
73.00
182.41
iu/ml
—
5
48
12
106
1.14
0.10
5.8
3.1
42.75
43.34
u/ml
0.01
12
100
6
75
0.79
0.07
1.5
3.0
6.67
1976.72
u/ml
—
6
64
43
414
1.05
0.06
1.6
1.5
18.64
21.68
nmol/l
0.66
34
337
13
141
0.92
0.05
2.9
1.8
—
—
—
0
0
10
92
1.09
0.03
1.1
1.0
—
—
—
0
0
40
408
0.98
0.01
2.6
2.1
3.89
3.28
mg/l
0.71
35
353
16
156
1.03
0.00
6.4
3.2
4.19
4.54
kpa
0.59
16
151
29
286
1.02
0.00
1.6
1.4
—
—
—
0
0
136
1359
1.00
0.00
5.0
3.9
15.44
14.79
pmol/l
2.03
119
1231
21
215
0.97
0.00
10.8
6.5
105.14
103.81
mmol/l
0.79
21
215
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
57
0.87
-0.00
1.4
4.3
—
3.42
—
0
7
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
10.70
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
98
0.91
-0.00
17.9
11.5
26.13
24.74
mmol/l
—
9
92
Mortality – FinRegistry
↥Association
Association between endpoint G6_HCINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCINOTH | 5.144 [3.85, 6.87] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 238 out of 716 females with G6_HCINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCINOTH | 5.443 [3.94, 7.52] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 203 out of 639 males with G6_HCINOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_HCINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.386% | 0.987% |
| 5 | 3.0% | 6.198% |
| 10 | 6.745% | 15.626% |
| 15 | 12.709% | 27.03% |
| 20 | 20.651% | 42.374% |
Relationships between endpoints
↥Index endpoint: G6_HCINOTH – Hydrocephalus in other diseases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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