brain disease: A disease affecting the brain or part of the brain.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
190 |
4. Check minimum number of eventsNone |
190 |
5. Include endpointsNone |
190 |
6. Filter based on genotype QC (FinnGen only) |
190 |
Control definitions (FinnGen only)
- Control exclude
- G6_HYDROCEPH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Hydrocephalus in other diseases
based on the number of shared cases.
Similar with more cases:
- Hydrocephalus
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1769 | 924 | 839 |
| Only index persons | 1488 | 795 | 693 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 56.83 | 58.92 | 54.41 |
| Only index persons | 57.38 | 58.88 | 55.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 190 | 120 | 70 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | 60.27 | 59.94 | 60.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 174
- Matched controls
- 1737
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
1230.7
116.5
101
*
AAF00
NOMESCO Finland
Ventriculostomy
477.3
101.4
92
*
AA1AD
NOMESCO Finland
CT of head and brain
20.2
66.6
132
234
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
14.1
46.5
91
125
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
45.9
42
*
G94.2
ICD-10 Finland
Hydrocephalus in other diseases classified elsewhere
+∞
43.6
40
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
97.2
41.2
44
6
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
16.0
38.1
66
64
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
36.8
34
*
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
90.0
33.3
36
5
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
31.2
29
*
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
30.1
28
*
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
97.0
29.9
32
*
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
27.9
26
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
+∞
26.8
25
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
303.5
26.5
26
*
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
303.5
26.5
26
*
PA3AC
NOMESCO Finland
Carotis angiography with X-ray
289.9
25.4
25
*
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
145.0
24.3
25
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
9.3
24.2
54
80
K90
ICPC
Stroke/cerebrovascular accident
35.9
23.7
30
10
PA2AD
NOMESCO Finland
CT angiography of brain
75.8
23.6
26
*
AA5PD
NOMESCO Finland
CT examination of brain pefusion
45.2
22.5
27
7
PA4AC
NOMESCO Finland
Vertebralis angiography with X-ray
250.1
22.1
22
*
N03AX14
ATC
levetiracetam; systemic
23.9
21.3
30
15
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
+∞
20.2
19
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.9
19.9
84
278
WX730
NOMESCO Finland
Conventional respirator
39.4
19.5
24
7
G942, I602
ICD-10 Finland
NA
+∞
19.1
18
*
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
211.9
18.9
19
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
18.1
18.8
29
19
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
18.0
17
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.9
17.6
55
127
WX872
NOMESCO Finland
Intensive care
11.2
16.3
31
33
AA1AA
NOMESCO Finland
Head X-ray examination
66.4
16.1
18
*
AAF50
NOMESCO Finland
Third ventriculostomy
+∞
14.8
14
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
19.2
14.7
22
13
I61.5
ICD-10 Finland
Intracerebral haemorrhage, intraventricular
163.1
14.7
15
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
10.3
14.7
29
33
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
20.3
13.7
20
11
XX3DW
NOMESCO Finland
Time consuming IT work
5.9
13.5
40
84
H02AB02
ATC
dexamethasone; systemic
5.5
13.4
42
95
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
26.7
12.7
17
7
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
12.4
12.4
22
20
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
12.4
11.9
21
19
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
20.7
11.8
17
9
R51.80
ICD-10 Finland
Headache
4.2
11.7
49
149
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
16.6
11.6
18
12
G942, I615
ICD-10 Finland
NA
+∞
11.6
11
*
I60.6
ICD-10 Finland
Subarachnoid haemorrhage from other intracranial arteries
+∞
11.6
11
*
G91.8
ICD-10 Finland
Other hydrocephalus
+∞
11.6
11
*
PA2KT
NOMESCO Finland
Endovascular closure of brain aneurysm
128.1
11.6
12
*
I60.7
ICD-10 Finland
Subarachnoid haemorrhage from intracranial artery, unspecified
128.1
11.6
12
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
21.9
11.4
16
8
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
19.4
11.0
16
9
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
17.5
10.6
16
10
G942, I601
ICD-10 Finland
NA
+∞
10.5
10
*
G97.2
ICD-10 Finland
Intracranial hypotension following ventricular shunting
+∞
10.5
10
*
G94.1
ICD-10 Finland
Hydrocephalus in neoplastic disease
+∞
10.5
10
*
SPAT1215
SPAT
Assessment of need for medical rehabilitation
7.3
10.2
24
37
N18
ICPC
Paralysis/weakness
13.3
10.1
17
14
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
18.1
10.1
15
9
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
105.5
9.5
10
*
XX1ZW
NOMESCO Finland
Very extensive written report from radiologist
105.5
9.5
10
*
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
9.5
9
*
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
+∞
9.5
9
*
PA2MT
NOMESCO Finland
Endovascular closure of very extensive brain aneurysm
+∞
9.5
9
*
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
14.8
9.4
15
11
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
16.8
9.2
14
9
SPAT1229
SPAT
Assessment of need for aid
5.1
9.1
29
66
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
9.1
69
322
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
25.6
9.0
12
5
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.0
8.4
27
62
I60.8
ICD-10 Finland
Other subarachnoid haemorrhage
+∞
8.4
8
*
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
15.5
8.3
13
9
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
12.7
7.7
13
11
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
10.8
7.7
14
14
PA7BD
NOMESCO Finland
CT angiography of neck and brain
10.8
7.7
14
14
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
26.3
7.7
10
*
PA2YT
NOMESCO Finland
Cerebral artery PTA with stent
26.3
7.7
10
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.2
7.6
43
163
N29
ICPC
Neurological sympt/complt other
14.2
7.5
12
9
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
11.6
7.4
13
12
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
4.3
7.4
27
71
G942, I609
ICD-10 Finland
NA
+∞
7.3
7
*
G941, D431
ICD-10 Finland
NA
+∞
7.3
7
*
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
+∞
7.3
7
*
AAB30
NOMESCO Finland
Evacuation of spontaneous intracranial haematoma
+∞
7.3
7
*
G942, I600
ICD-10 Finland
NA
+∞
7.3
7
*
G942, I690
ICD-10 Finland
NA
+∞
7.3
7
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.5
7.3
15
19
N03AF02
ATC
oxcarbazepine; oral
8.5
7.3
15
19
ZXC86
NOMESCO Finland
Use of endoscopic device
31.4
7.2
9
*
D21
ICPC
Swallowing problem
12.8
7.2
12
10
WX882
NOMESCO Finland
High dependency care
6.9
7.1
17
27
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.6
7.1
66
336
SPAT1231
SPAT
Assessment of adjustments needed in living environment
14.6
7.0
11
8
D33.30
ICD-10 Finland
Acoustic neuroma
41.7
6.8
8
*
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
23.6
6.7
9
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
9.3
6.7
13
15
SPAT1216
SPAT
Assessment of functional ability
3.1
6.6
38
145
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
15.0
6.5
10
7
NK6AI
NOMESCO Finland
Other cone beam scan
72.4
6.5
7
*
G41.9
ICD-10 Finland
Status epilepticus, unspecified
72.4
6.5
7
*
C79.31
ICD-10 Finland
Secondary malignant tumor of the cerebellum
72.4
6.5
7
*
K91
ICPC
Cerebrovascular disease
18.9
6.3
9
5
I60.4
ICD-10 Finland
Subarachnoid haemorrhage from basilar artery
+∞
6.3
6
*
G942, I606
ICD-10 Finland
NA
+∞
6.3
6
*
L01AX03
ATC
temozolomide; systemic
+∞
6.3
6
*
I60.5
ICD-10 Finland
Subarachnoid haemorrhage from vertebral artery
+∞
6.3
6
*
C71.90
ICD-10 Finland
Malignant tumor in unspecified localization in the brain without histology
+∞
6.3
6
*
L28
ICPC
Limited function/disability (L)
2.9
6.1
40
164
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
7.7
6.0
13
18
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
73
12
98.17
136.68
3.7
1.0
—
—
—
0
0
45
41
14.07
44.12
2.5
1.7
—
—
—
0
0
35
6
70.93
31.32
3.9
1.0
—
—
—
0
0
26
8
37.32
20.80
2.6
1.0
55.81
—
%
—
16
0
125
599
4.18
20.20
3.9
3.9
40.01
32.55
ng/l
0.18
101
414
55
157
4.52
18.17
4.2
3.8
—
—
—
0
0
32
58
6.43
17.63
1.5
2.3
—
—
—
0
0
23
30
8.58
16.94
2.8
2.8
18.14
14.96
%
—
9
11
29
56
5.93
14.91
1.6
1.9
—
—
—
0
0
15
17
9.49
12.17
3.1
1.2
284.53
277.08
mosm/kgh2o
0.42
15
12
141
918
3.08
10.77
7.2
5.1
6.52
6.60
mmol/l
0.23
136
852
34
99
3.96
10.60
6.7
4.8
2.26
1.49
mmol/l
0.56
28
74
38
138
3.19
8.42
13.1
7.4
6.37
9.63
mmol/l
3.14
38
131
10
13
8.06
7.19
3.6
1.7
22.90
18.11
ug/l
—
10
13
6
0
+∞
6.28
5.7
0.0
0.07
—
ug/l
—
6
0
71
407
2.19
6.02
6.3
4.0
0.00
0.00
estimate
0.00
36
147
48
243
2.30
5.43
1.9
2.0
—
—
—
0
0
105
721
2.02
5.33
6.3
4.3
—
—
—
0
0
135
1596
0.47
4.99
4.8
5.1
2.64
2.76
mmol/l
0.74
118
1460
62
367
2.02
4.65
4.7
2.4
—
—
—
0
0
132
1024
1.95
4.28
7.3
4.3
181.60
247.35
e6/l
—
10
17
88
600
1.87
4.27
6.4
3.7
—
—
—
0
0
108
796
1.83
4.00
10.7
7.6
1.22
1.22
mmol/l
0.07
75
671
134
1563
0.52
3.93
4.6
4.5
1.43
1.50
mmol/l
1.10
118
1430
108
1341
0.55
3.90
26.4
17.6
13.75
13.79
%
0.09
108
1323
10
26
4.00
3.57
1.2
1.7
—
—
—
0
0
10
26
4.00
3.57
1.2
1.7
—
—
—
0
0
10
26
4.00
3.57
1.2
1.7
—
—
—
0
0
10
26
4.00
3.57
1.1
1.7
—
—
—
0
0
10
26
4.00
3.57
1.2
1.7
—
—
—
0
0
6
6
10.27
3.52
2.2
1.0
—
—
—
0
0
99
732
1.74
3.45
9.3
6.7
1.22
1.22
mmol/l
0.09
89
662
125
1474
0.56
3.44
6.9
5.7
40.24
39.96
mmol/mol
0.12
110
1364
10
27
3.85
3.40
1.2
1.7
—
—
—
0
0
11
32
3.59
3.39
6.2
3.2
51.55
60.72
%
1.09
11
32
11
32
3.59
3.39
4.2
2.7
4.28
5.09
e9/l
0.20
11
32
8
14
5.91
3.37
1.3
1.1
—
—
—
0
0
137
1572
0.54
3.37
4.6
4.5
4.51
4.70
mmol/l
1.16
119
1450
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
7
8.80
3.28
1.5
1.0
—
—
—
0
0
25
119
2.27
3.22
2.2
1.5
—
—
—
0
0
52
327
1.81
3.12
1.4
1.9
514.60
473.14
pmol/l
0.28
40
263
9
22
4.24
2.92
1.4
1.2
—
—
—
0
0
124
1446
0.59
2.87
16.8
15.1
37.11
39.94
%
1.14
50
1059
108
844
1.65
2.86
10.6
6.5
8.08
10.71
umol/l
4.63
102
806
5
6
8.51
2.76
2.8
1.8
—
—
—
0
0
5
6
8.51
2.76
1.6
1.0
—
—
—
0
0
18
81
2.35
2.63
1.3
1.6
—
—
—
0
0
11
38
3.01
2.63
1.6
1.3
—
—
—
0
0
18
82
2.32
2.57
1.9
1.3
—
—
—
0
0
5
7
7.30
2.56
6.2
3.6
—
—
—
0
0
12
45
2.78
2.50
2.7
1.9
—
—
—
0
0
10
34
3.05
2.45
2.1
1.5
—
—
—
0
0
97
760
1.56
2.40
6.2
3.7
0.00
0.00
estimate
0.00
39
152
7
17
4.23
2.38
3.4
1.4
—
—
—
0
0
155
1688
0.56
2.34
14.7
10.7
28.62
25.80
u/l
1.13
146
1623
69
502
1.59
2.34
2.9
2.4
46.85
56.22
u/l
2.56
62
464
8
23
3.58
2.29
2.9
1.5
—
—
—
0
0
62
442
1.60
2.28
3.1
3.3
632.61
1114.35
ng/l
1.94
54
368
75
564
1.54
2.17
5.5
3.1
—
—
—
0
0
11
43
2.65
2.13
1.4
1.5
—
—
—
0
0
97
775
1.51
2.10
6.3
3.7
0.00
0.00
estimate
0.00
39
145
16
303
0.48
2.09
1.8
1.6
—
—
—
0
0
96
768
1.51
2.06
7.8
5.0
0.00
0.00
estimate
0.00
38
149
7
21
3.42
1.98
1.7
2.1
—
—
—
0
0
135
1506
0.64
1.95
4.5
4.0
1.34
1.29
mmol/l
0.38
121
1369
14
267
0.49
1.86
2.8
2.7
1.12
0.96
e6/l
—
9
150
6
17
3.61
1.85
1.3
1.1
—
—
—
0
0
0
48
0.00
1.72
0.0
1.1
—
—
—
0
0
30
447
0.61
1.71
1.7
1.7
1.33
1.38
mmol/l
0.15
20
376
33
216
1.64
1.69
4.2
4.5
32.69
32.03
%
0.16
26
144
8
31
2.65
1.68
3.6
1.9
—
—
—
0
0
41
287
1.55
1.59
2.0
1.7
1309.76
1239.65
nmol/l
0.18
33
215
6
21
2.92
1.52
1.7
2.1
—
—
—
0
0
84
997
0.72
1.44
2.6
3.0
—
—
—
0
0
6
22
2.78
1.44
12.0
3.4
48.67
82.71
u/ml
—
6
22
10
46
2.24
1.42
3.2
1.9
—
—
—
0
0
11
53
2.14
1.41
2.0
2.5
—
—
—
0
0
5
17
2.99
1.36
1.0
1.4
—
0.29
nmol/l
—
0
10
0
38
0.00
1.36
0.0
1.1
—
17.53
—
0
6
5
18
2.82
1.29
1.0
1.0
—
—
—
0
0
5
18
2.82
1.29
1.0
1.0
—
—
—
0
0
144
1554
0.70
1.26
4.4
4.6
6.04
5.92
mmol/l
0.41
121
1417
21
315
0.63
1.21
3.9
4.4
22.75
22.29
%
0.06
11
148
6
26
2.35
1.19
1.8
1.3
—
—
—
0
0
8
147
0.52
1.09
24.4
11.1
117.75
119.59
g/l
—
8
140
5
22
2.31
1.04
1.0
1.3
—
—
—
0
0
115
1028
1.30
0.98
4.9
3.2
64.21
46.78
u/l
0.71
107
969
45
354
1.36
0.95
2.2
1.8
0.59
1.31
mg/l
3.50
37
279
32
418
0.72
0.92
3.3
3.0
350.56
8128.81
umol/l
2.51
27
356
25
181
1.44
0.85
13.8
20.1
1.09
1.35
inr
—
8
22
0
25
0.00
0.79
0.0
1.1
—
—
—
0
0
5
26
1.95
0.71
3.8
1.5
—
—
—
0
0
11
167
0.64
0.69
18.8
10.2
17.16
12.15
kpa
0.83
11
160
11
167
0.64
0.69
18.8
10.1
4.97
5.18
kpa
0.65
11
160
133
1237
1.25
0.69
10.9
7.7
83.59
81.58
u/l
0.13
124
1158
22
291
0.72
0.69
2.8
3.4
1732.00
126.81
ng/l
0.44
12
226
140
1482
0.79
0.69
5.4
4.8
1.78
2.76
mu/l
0.63
119
1338
7
42
1.69
0.69
1.7
1.9
—
—
—
0
0
113
1222
0.81
0.67
5.1
4.1
13.13
12.33
mm/h
0.20
102
1114
59
676
0.82
0.61
3.6
2.7
167.78
114.91
ug/l
0.80
49
623
14
196
0.69
0.61
2.1
6.8
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
3.51
—
0
10
0
20
0.00
0.60
0.0
1.1
—
7.33
—
0
11
0
20
0.00
0.60
0.0
1.8
—
—
—
0
0
31
376
0.79
0.54
1.3
1.3
0.81
1.87
u/ml
—
9
99
52
451
1.21
0.52
5.3
2.9
0.31
0.49
e6/l
0.58
46
339
7
45
1.58
0.49
1.0
1.3
—
—
—
0
0
7
45
1.58
0.49
2.0
1.9
—
—
—
0
0
23
285
0.78
0.48
1.3
1.3
1.40
13.06
u/ml
—
7
104
55
620
0.84
0.47
1.9
1.9
107.61
97.61
pmol/l
0.67
38
297
6
92
0.64
0.43
14.8
11.6
25.48
24.75
mmol/l
—
6
84
5
33
1.53
0.41
2.6
1.8
—
—
—
0
0
25
301
0.80
0.41
1.3
1.3
75.16
29.96
iu/ml
—
7
112
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
13
170
0.75
0.40
3.1
1.9
—
—
—
0
0
154
1486
1.19
0.38
21.8
13.4
85.72
80.68
ml/min/173m2
2.36
140
1204
8
115
0.68
0.38
2.4
2.3
143.63
173.13
ng/l
—
8
105
73
671
1.14
0.36
2.7
2.4
80.20
77.76
nmol/l
0.24
66
598
53
477
1.15
0.35
3.6
4.0
5.00
7.77
mg/mmol
0.40
31
289
6
47
1.29
0.32
2.2
1.4
—
—
—
0
0
7
99
0.70
0.31
10.6
3.7
24.10
23.93
mmol/l
—
7
94
61
559
1.13
0.31
3.6
3.4
2.34
2.36
mmol/l
0.42
53
485
16
134
1.21
0.23
1.5
2.3
8.30
5.17
ug/l
0.24
11
116
72
677
1.10
0.23
7.6
4.6
33.07
35.79
g/l
2.74
63
640
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.6
—
—
—
0
0
0
13
0.00
0.21
0.0
2.5
—
793.54
—
0
13
0
13
0.00
0.21
0.0
1.0
—
494.00
—
0
8
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
42.50
—
0
8
12
142
0.83
0.18
2.7
1.9
—
—
—
0
0
15
167
0.89
0.11
2.7
1.8
—
—
—
0
0
40
380
1.07
0.10
1.5
1.5
18.30
21.84
nmol/l
0.73
31
312
35
369
0.94
0.09
2.4
2.2
3.75
3.32
mg/l
0.46
30
319
6
70
0.85
0.08
1.5
3.2
6.67
2073.57
u/ml
—
6
61
16
147
1.10
0.07
6.4
3.2
4.19
4.52
kpa
0.54
16
142
24
255
0.93
0.07
1.5
1.4
—
—
—
0
0
123
1242
0.97
0.03
5.1
4.0
15.48
14.78
pmol/l
2.06
107
1126
12
128
0.93
0.02
2.6
1.8
—
—
—
0
0
160
1594
1.02
0.00
27.7
14.2
18.77
22.24
mg/l
0.75
147
1228
10
103
0.97
0.00
4.9
3.1
46.80
44.22
u/ml
—
10
97
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
5
53
0.94
0.00
1.4
4.3
—
3.76
—
0
6
5
49
1.02
0.00
1.2
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
8
87
0.92
0.00
1.1
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
10.70
—
0
6
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
0.00
0.0
2.9
—
53.44
—
0
9
7
78
0.89
0.00
17.4
10.3
24.20
24.76
mmol/l
—
7
73
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_HCINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCINOTH | 5.144 [3.85, 6.87] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 238 out of 716 females with G6_HCINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCINOTH | 5.443 [3.94, 7.52] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 203 out of 639 males with G6_HCINOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_HCINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.386% | 0.987% |
| 5 | 3.0% | 6.198% |
| 10 | 6.745% | 15.626% |
| 15 | 12.709% | 27.03% |
| 20 | 20.651% | 42.374% |
Relationships between endpoints
↥Index endpoint: G6_HCINOTH – Hydrocephalus in other diseases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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