tarsal tunnel syndrome: Tarsal tunnel syndrome is a nerve disorder that is characterized by pain in the ankle, foot, and toes. This condition is caused by compression of the posterior tibial nerve, which runs through a canal near the heel into the sole of the foot. When tissues around this nerve become inflamed, they can press on the nerve and cause the pain associated with tarsal tunnel syndrome.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
367 |
4. Check minimum number of eventsNone |
367 |
5. Include endpointsNone |
367 |
6. Filter based on genotype QC (FinnGen only) |
367 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G57
- Name in latin
- Syndroma canalis tarsi
Similar endpoints
↥List of similar endpoints to
Tarsal tunnel syndrome
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2313 | 1573 | 732 |
| Only index persons | 2188 | 1518 | 670 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 50.86 | 51.67 | 49.08 |
| Only index persons | 50.63 | 51.61 | 48.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 367 | 279 | 88 |
| Unadjusted period prevalence (%) | 0.08 | 0.10 | 0.04 |
| Median age at first event (years) | 51.19 | 50.96 | 51.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 332
- Matched controls
- 3318
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G57.5
ICD-10 Finland
Tarsal tunnel syndrome
10047.1
323.0
289
*
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
327.2
114.7
110
5
3555A
ICD-9 Finland
Mononeuritis of lower limb, Tarsal tunnel syndrome
+∞
53.6
50
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
18.1
45.2
72
50
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
133.0
44.0
46
*
ACC51
NOMESCO Finland
Release of median nerve
188.7
33.4
34
*
N03AX16
ATC
pregabalin; oral
4.5
30.8
137
448
G57.6
ICD-10 Finland
Lesion of plantar nerve
45.2
24.0
29
7
N02AX02
ATC
tramadol; systemic, rectal
3.3
23.4
186
929
N03AX12
ATC
gabapentin; oral
4.6
23.2
92
257
ACC55
NOMESCO Finland
Release of tibial nerve
+∞
18.9
18
*
M79.6
ICD-10 Finland
Pain in limb
2.9
18.3
161
814
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.8
18.1
191
1078
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
4.6
16.3
60
152
M77.4
ICD-10 Finland
Metatarsalgia
6.2
16.3
45
82
M54.4
ICD-10 Finland
Lumbago with sciatica
3.6
15.6
79
267
M01AH05
ATC
etoricoxib; oral
2.6
14.7
231
1557
M01AC06
ATC
meloxicam; systemic, rectal
2.5
14.5
162
905
A02BC03
ATC
lansoprazole; oral
2.6
13.8
127
630
L16
ICPC
Ankle symptom/complaint
3.9
13.4
58
170
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
3.4
13.3
69
236
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.8
12.7
93
402
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
4.5
12.4
45
112
M01AX17
ATC
nimesulide; oral
2.6
12.2
107
513
M25.5
ICD-10 Finland
Pain in joint
2.5
12.1
122
628
N06AX21
ATC
duloxetine; oral
3.6
11.7
55
173
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.3
11.3
59
202
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.5
11.2
54
173
M01AH02
ATC
rofecoxib; oral
3.0
11.1
70
272
N02AJ06
ATC
codeine and paracetamol; systemic
2.3
11.1
138
784
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
6.9
11.0
27
42
XA402
NOMESCO Finland
ENMG
12.5
11.0
19
16
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
10.7
134
762
M03BX02
ATC
tizanidine; oral
2.2
10.6
230
1667
NHM10
NOMESCO Finland
Fasciotomy of ankle or foot
33.7
10.4
13
*
L17
ICPC
Foot/toe symptom/complaint
2.4
10.2
104
532
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
11.1
9.9
18
17
M48.0
ICD-10 Finland
Spinal stenosis
3.1
9.9
56
202
NHL50
NOMESCO Finland
Tenolysis or tenosynovectomy of foot
27.0
9.9
13
5
M01AB05
ATC
diclofenac; systemic, rectal
2.2
9.9
239
1790
M77.1
ICD-10 Finland
Lateral epicondylitis
4.0
9.8
39
106
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
9.7
146
890
A02BC02
ATC
pantoprazole; systemic
2.1
9.5
234
1748
M02AA07
ATC
piroxicam; topical
2.1
9.5
147
906
M01AE02
ATC
naproxen; oral, rectal
2.1
9.4
203
1431
ZXA00
NOMESCO Finland
Right side
2.3
9.2
105
563
N02BE01
ATC
paracetamol; systemic, rectal
2.7
9.1
297
2508
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
9.9
8.9
17
18
J01DA01
ATC
[U] cefalexin; systemic
2.1
8.8
224
1666
M01AX05
ATC
glucosamine; oral
2.3
8.5
91
469
G57.8
ICD-10 Finland
Other mononeuropathies of lower limb
+∞
8.4
8
*
G57.4
ICD-10 Finland
Lesion of medial popliteal nerve
+∞
8.4
8
*
WX320
NOMESCO Finland
Spinalanesthesy
2.3
8.3
86
438
L03
ICPC
Low back symptom/complaint
2.2
8.2
95
507
N06AA09
ATC
amitriptyline; systemic
2.9
8.0
50
192
H02AB06
ATC
prednisolone; systemic
2.0
8.0
165
1115
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
3.0
7.7
45
167
E66.8
ICD-10 Finland
Other obesity
4.3
7.6
27
67
J01FA10
ATC
azithromycin; systemic
1.9
7.6
208
1545
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
7.5
79
403
ACC19
NOMESCO Finland
Transcision of peripheral nerve: other or unspecified
81.8
7.4
8
*
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
3.8
7.4
30
84
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
4.0
7.4
28
74
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
6.5
7.3
18
29
L11
ICPC
Wrist symptom/complaint
3.5
7.1
32
98
J01AA02
ATC
doxycycline; systemic
2.1
7.0
268
2220
M03BC51
ATC
orphenadrine, combinations; systemic
2.0
7.0
107
637
A02BA02
ATC
ranitidine; systemic
2.2
7.0
78
407
SPAT1216
SPAT
Assessment of functional ability
2.4
7.0
59
270
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.0
7.0
21
44
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
4.1
7.0
26
68
L28
ICPC
Limited function/disability (L)
2.4
6.9
61
285
M70.6
ICD-10 Finland
Trochanteric bursitis
2.5
6.8
55
246
J01FF01
ATC
clindamycin; systemic
2.0
6.8
99
580
R52.9
ICD-10 Finland
Pain, unspecified
3.1
6.7
35
120
R06.0
ICD-10 Finland
Dyspnoea
2.0
6.7
94
542
M54.5
ICD-10 Finland
Low back pain
1.9
6.7
115
715
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.1
6.6
84
463
J01DB01
ATC
cefalexin; oral
2.1
6.6
273
2295
N02AA05
ATC
oxycodone; systemic
2.5
6.5
51
226
G51.0
ICD-10 Finland
Bell palsy
71.2
6.4
7
*
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.9
6.4
107
655
3540A
ICD-9 Finland
Mononeuritis of upper limb and mononeuritis multiplex, Carpal tunnel syndrome
+∞
6.3
6
*
M76.6
ICD-10 Finland
Achilles tendinitis
3.8
6.2
25
70
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.8
6.2
39
150
Mortality – FinRegistry
↥Association
Association between endpoint G6_TARSTUN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_TARSTUN | 0.804 [0.66, 0.97] | 0.026 |
| Birth year | 0.994 [0.99, 1.0] | 0.166 |
During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 1139 females with G6_TARSTUN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_TARSTUN | 0.961 [0.76, 1.22] | 0.747 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 501 males with G6_TARSTUN died.
Mortality risk
Mortality risk for people of age
years, who have G6_TARSTUN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.078% | 0.209% |
| 5 | 0.458% | 1.193% |
| 10 | 1.154% | 2.996% |
| 15 | 2.191% | 5.581% |
| 20 | 4.018% | 9.683% |
Relationships between endpoints
↥Index endpoint: G6_TARSTUN – Tarsal tunnel syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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