tarsal tunnel syndrome: Tarsal tunnel syndrome is a nerve disorder that is characterized by pain in the ankle, foot, and toes. This condition is caused by compression of the posterior tibial nerve, which runs through a canal near the heel into the sole of the foot. When tissues around this nerve become inflamed, they can press on the nerve and cause the pain associated with tarsal tunnel syndrome.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
383 |
4. Check minimum number of eventsNone |
383 |
5. Include endpointsNone |
383 |
6. Filter based on genotype QC (FinnGen only) |
368 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G57
- Name in latin
- Syndroma canalis tarsi
Similar endpoints
↥List of similar endpoints to
Tarsal tunnel syndrome
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2313 | 1573 | 732 |
| Only index persons | 2188 | 1518 | 670 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 50.86 | 51.67 | 49.08 |
| Only index persons | 50.63 | 51.61 | 48.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 368 | 279 | 89 |
| Unadjusted period prevalence (%) | 0.08 | 0.10 | 0.04 |
| Median age at first event (years) | 51.49 | 51.23 | 52.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 383
- Matched controls
- 3830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G57.5
ICD-10 Finland
Tarsal tunnel syndrome
+∞
307.7
338
*
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
456.4
131.2
124
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
20.5
107.0
88
55
3555A
ICD-9 Finland
Mononeuritis of lower limb, Tarsal tunnel syndrome
+∞
56.7
53
*
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
186.7
48.1
49
*
N03AX16
ATC
[U] pregabalin
4.7
46.7
163
526
ACC51
NOMESCO Finland
Release of median nerve
247.7
43.9
44
*
N03AX12
ATC
[U] gabapentin; oral
4.9
42.5
121
330
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
5.4
34.0
77
171
N02AX02
ATC
tramadol; systemic, rectal
3.3
28.7
217
1094
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
5.8
28.6
57
112
ACC55
NOMESCO Finland
Release of tibial nerve
+∞
28.5
27
*
M79.6
ICD-10 Finland
Pain in limb
3.1
26.3
223
1183
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
4.0
26.0
89
271
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.9
25.2
87
266
M54.4
ICD-10 Finland
Lumbago with sciatica
3.5
24.7
107
380
G57.6
ICD-10 Finland
Lesion of plantar nerve
21.2
23.9
35
18
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.9
23.4
219
1201
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
7.1
21.7
34
52
N06AX21
ATC
duloxetine; oral
3.8
21.6
77
239
M77.4
ICD-10 Finland
Metatarsalgia
4.8
21.1
52
122
L16
ICPC
Ankle symptom/complaint
3.6
20.1
77
250
M01AC06
ATC
meloxicam; systemic, rectal
2.6
18.9
188
1031
M25.5
ICD-10 Finland
Pain in joint
2.6
18.8
170
889
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.6
18.7
69
218
L17
ICPC
Foot/toe symptom/complaint
2.7
18.6
151
749
M01AH05
ATC
etoricoxib; oral
2.8
18.0
279
1879
M01AH02
ATC
rofecoxib; oral
3.2
16.6
77
280
M01AH03
ATC
valdecoxib; oral
4.6
16.2
41
98
N06AA09
ATC
amitriptyline; systemic
3.6
16.1
59
185
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.6
15.4
113
525
A02BC03
ATC
lansoprazole; oral
2.4
15.0
144
758
M48.0
ICD-10 Finland
Spinal stenosis
3.2
14.9
65
227
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
26.3
14.8
20
8
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
14.3
165
939
L03
ICPC
Low back symptom/complaint
2.4
14.2
132
683
M54.5
ICD-10 Finland
Low back pain
2.3
14.0
165
944
M03BX02
ATC
tizanidine; oral
2.4
14.0
269
1892
M77.1
ICD-10 Finland
Lateral epicondylitis
3.7
13.6
46
136
A02BC02
ATC
pantoprazole; systemic
2.5
13.6
288
2100
M01AE03
ATC
ketoprofen; systemic, rectal
2.3
13.5
173
1021
M01AB05
ATC
diclofenac; systemic, rectal
2.5
13.5
284
2061
M01AX17
ATC
nimesulide; oral
2.4
13.5
121
614
M02AA07
ATC
piroxicam; topical
2.3
13.4
171
1007
NHL50
NOMESCO Finland
Tenolysis or tenosynovectomy of foot
29.5
13.1
17
6
E66.8
ICD-10 Finland
Other obesity
4.2
12.5
34
86
H02AB06
ATC
prednisolone; systemic
2.1
12.1
203
1318
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
4.0
12.0
36
98
M01AB55
ATC
diclofenac, combinations; oral
3.5
11.7
42
129
XA402
NOMESCO Finland
ENMG
9.7
11.7
23
25
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.2
11.6
51
178
NHM10
NOMESCO Finland
Fasciotomy of ankle or foot
20.8
11.2
16
8
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.7
11.1
26
58
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
4.1
11.1
31
80
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
11.1
102
518
M01AX05
ATC
glucosamine; oral
2.3
11.0
103
526
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.2
11.0
46
156
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.0
10.7
50
181
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
10.5
10.6
20
20
R06.0
ICD-10 Finland
Dyspnoea
2.2
10.5
120
664
M70.6
ICD-10 Finland
Trochanteric bursitis
2.5
10.5
76
346
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
3.5
10.1
37
115
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.2
10.0
113
620
N06AX16
ATC
venlafaxine; oral
2.5
10.0
70
313
M01AH01
ATC
celecoxib; oral
2.3
10.0
88
437
L08
ICPC
Shoulder symptom/complaint
2.3
9.9
96
495
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
9.6
74
346
M76.6
ICD-10 Finland
Achilles tendinitis
3.7
9.6
31
89
H02BX01
ATC
methylprednisolone, combinations; systemic
3.7
9.6
31
89
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.8
9.5
52
205
M54.1
ICD-10 Finland
Radiculopathy
4.4
9.5
24
57
ACC19
NOMESCO Finland
Transcision of peripheral nerve: other or unspecified
102.5
9.5
10
*
M01AE02
ATC
naproxen; oral, rectal
2.0
9.4
237
1724
A01
ICPC
Pain general/multiple sites
2.7
8.9
49
194
N02AJ06
ATC
codeine and paracetamol; systemic
1.9
8.9
174
1156
D07AC01
ATC
betamethasone; topical
1.9
8.7
149
944
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
4.9
8.7
19
40
M67.4
ICD-10 Finland
Ganglion
3.0
8.7
39
138
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.2
8.5
34
112
G57.8
ICD-10 Finland
Other mononeuropathies of lower limb
92.0
8.4
9
*
G57.4
ICD-10 Finland
Lesion of medial popliteal nerve
+∞
8.4
8
*
R52.2
ICD-10 Finland
Other chronic pain
4.1
8.3
23
59
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.9
8.3
187
1293
ZXA00
NOMESCO Finland
Right side
2.0
8.3
116
685
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
8.2
125
759
M22.4
ICD-10 Finland
Chondromalacia patellae
4.9
8.2
18
38
J01DA01
ATC
[U] cefalexin
1.9
8.2
253
1930
L28
ICPC
Limited function/disability (L)
2.2
8.1
80
414
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.1
8.0
98
549
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
3.5
8.0
28
85
M79.7
ICD-10 Finland
Fibromyalgia
3.9
7.9
23
61
M02AA10
ATC
ketoprofen; topical
2.2
7.9
72
360
WX320
NOMESCO Finland
Spinalanesthesy
2.0
7.8
109
640
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.4
7.8
55
246
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
4.5
7.8
19
44
N03AX09
ATC
lamotrigine; oral
3.8
7.7
24
67
N02BF01
ATC
gabapentin; oral
2.9
7.7
37
136
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
7.7
63
301
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.5
7.7
50
215
M54.3
ICD-10 Finland
Sciatica
3.4
7.7
28
87
J01DB01
ATC
cefalexin; oral
2.2
7.7
324
2720
A02BC05
ATC
esomeprazole; systemic
1.8
7.5
168
1148
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.4
7.4
56
258
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
3.6
7.4
24
69
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.0
7.4
106
628
A02BA03
ATC
famotidine; systemic
4.3
7.4
19
46
A02BA02
ATC
ranitidine; systemic
2.1
7.3
85
466
G51.0
ICD-10 Finland
Bell palsy
+∞
7.3
7
*
A04
ICPC
Weakness/tiredness general
2.3
7.3
61
294
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
4.6
7.2
17
38
M01AX01
ATC
nabumetone; oral
3.5
7.2
25
75
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
7.2
116
713
J01FA10
ATC
azithromycin; systemic
1.8
7.2
237
1810
N02BE01
ATC
paracetamol; systemic, rectal
2.7
7.2
350
3059
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.9
7.1
35
130
M01AC01
ATC
piroxicam; systemic, rectal
2.3
7.1
61
297
N06AB03
ATC
fluoxetine; oral
2.2
7.1
61
298
R09
ICPC
Sinus symptom/complaint
2.6
7.0
42
173
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.8
7.0
215
1602
L11
ICPC
Wrist symptom/complaint
2.7
6.9
38
150
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.9
6.9
120
756
R52.9
ICD-10 Finland
Pain, unspecified
2.4
6.8
48
214
J01AA02
ATC
doxycycline; systemic
2.0
6.8
308
2573
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
3.5
6.8
23
68
M03BC51
ATC
orphenadrine, combinations; systemic
1.8
6.8
122
774
L86
ICPC
Back syndrome with radiating pain
3.1
6.8
28
94
S18
ICPC
Laceration/cut
1.8
6.8
178
1264
A02BC01
ATC
omeprazole; systemic
1.9
6.8
108
660
SPAT1216
SPAT
Assessment of functional ability
2.1
6.7
68
354
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.1
6.7
66
340
ZA7.0
ICD-10 Finland
Ankle and foot
8.0
6.7
14
18
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
3.0
6.6
29
101
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.9
6.6
32
118
R01AD12
ATC
fluticasone furoate; nasal
1.8
6.6
127
822
ZXD20
NOMESCO Finland
Day surgery
2.2
6.6
60
299
R01BA52
ATC
pseudoephedrine, combinations; oral
1.8
6.5
132
867
TAB20
NOMESCO Finland
Epidural puncture
14.6
6.4
10
7
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
2.7
6.4
34
132
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
5.7
6.4
17
31
SPAT1153
SPAT
Removal of sutures
1.8
6.4
125
813
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.6
6.4
39
163
J01FF01
ATC
clindamycin; systemic
1.8
6.3
111
697
M01AB08
ATC
etodolac; oral
2.7
6.3
35
139
3540A
ICD-9 Finland
Mononeuritis of upper limb and mononeuritis multiplex, Carpal tunnel syndrome
+∞
6.3
6
*
G57.9
ICD-10 Finland
Mononeuropathy of lower limb, unspecified
+∞
6.3
6
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
2.3
6.3
50
236
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
27.2
6.3
8
*
ZXA05
NOMESCO Finland
Left side
1.9
6.2
101
619
R01AD09
ATC
mometasone; nasal
1.7
6.2
183
1333
X59
ICD-10 Finland
Exposure to unspecified factor
2.0
6.2
74
409
SPAT1307
SPAT
Psychosocial counselling and guidance
3.4
6.1
22
68
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.8
6.1
31
118
M47.9
ICD-10 Finland
Spondylosis, unspecified
6.2
6.1
15
25
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
2.1
6.1
58
295
SAA01
NOMESCO Finland
Simple examination of mouth
1.8
6.0
274
2242
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
184
1277
1.85
7.94
2.2
1.9
95.45
97.20
pmol/l
0.22
99
606
236
1782
1.85
7.63
3.9
4.2
7.01
6.57
mmol/l
1.17
223
1668
94
530
2.03
7.54
1.4
1.3
13.02
14.76
u/ml
0.07
42
221
96
581
1.87
6.14
4.7
3.6
268.35
280.42
ng/l
0.03
72
443
304
2561
1.91
6.12
4.5
4.1
14.64
14.83
pmol/l
0.77
295
2325
190
1422
1.67
5.66
3.1
2.4
—
—
—
0
0
204
1560
1.66
5.55
4.5
3.6
0.00
0.00
estimate
-0.00
25
311
110
718
1.75
5.41
1.7
1.6
1.51
0.99
mg/l
0.44
89
552
133
917
1.69
5.35
1.8
2.1
137.79
162.96
u/l
0.86
123
860
187
1418
1.62
5.13
20.4
13.8
1.35
1.23
inr
0.86
51
433
181
1362
1.62
5.12
2.3
2.2
75.45
78.58
nmol/l
0.78
164
1210
83
508
1.81
5.05
2.8
2.5
0.55
0.99
e6/l
2.08
53
263
100
652
1.72
4.88
5.9
4.0
1.01
1.02
kg/l
0.65
18
76
203
1583
1.60
4.87
5.7
4.9
0.00
0.00
estimate
-0.00
23
291
89
564
1.75
4.80
1.3
1.2
19.43
34.48
iu/ml
0.99
28
197
353
3209
2.28
4.68
16.9
12.8
20.08
22.28
mg/l
0.70
299
2460
203
1598
1.58
4.57
4.6
3.6
0.00
0.02
estimate
0.80
23
291
289
2486
1.66
4.37
7.6
7.0
78.38
77.72
u/l
0.07
284
2331
156
1167
1.57
4.32
3.5
3.4
63.88
29.70
ng/l
0.56
98
797
134
968
1.59
4.31
2.7
2.2
50.09
63.98
u/l
1.77
127
887
336
3022
1.91
4.25
5.6
4.9
1.88
2.29
mu/l
0.50
331
2769
107
742
1.61
4.05
1.6
1.5
20.09
21.73
nmol/l
0.56
97
625
63
383
1.77
3.88
2.9
2.1
18.78
23.09
%
1.48
53
335
204
1653
1.50
3.74
5.7
5.9
10.42
10.86
umol/l
0.28
195
1565
74
479
1.68
3.64
2.9
2.6
4.57
2.78
e6/l
0.36
44
235
52
305
1.82
3.61
2.6
2.1
27.58
32.36
u/l
0.54
45
252
367
3445
2.56
3.57
18.9
14.9
71.90
73.49
umol/l
0.45
367
3445
190
1542
1.46
3.32
5.7
6.0
1.22
1.22
mmol/l
0.47
175
1311
100
725
1.51
3.03
2.7
2.0
3.08
3.11
mg/l
0.03
86
614
106
779
1.50
3.01
2.1
2.5
3371.90
7313.06
umol/l
0.57
97
678
168
1353
1.43
2.95
3.3
2.6
122.81
107.79
ug/l
0.28
161
1242
173
1406
1.42
2.87
5.0
5.1
1.22
1.22
mmol/l
0.23
165
1278
217
1836
1.42
2.86
8.7
9.2
3.96
4.03
e9/l
0.19
198
1592
53
337
1.66
2.79
1.8
1.8
—
—
—
0
0
130
1010
1.43
2.74
3.2
3.0
28.63
31.05
u/l
0.61
122
960
52
334
1.64
2.64
1.7
1.8
—
—
—
0
0
179
1480
1.39
2.62
6.7
5.9
28.96
27.83
%
0.73
172
1386
52
337
1.63
2.55
2.4
2.4
7.08
8.03
umol/l
0.18
45
293
96
714
1.46
2.53
1.2
1.2
0.82
1.98
u/ml
1.10
32
204
21
102
2.12
2.52
2.0
4.7
1.49
1.47
%
0.04
21
97
177
1473
1.37
2.44
6.6
5.6
56.78
57.43
%
0.34
171
1378
327
3027
1.55
2.39
6.5
5.3
40.00
39.40
mmol/mol
0.62
316
2822
5
8
6.31
2.38
1.6
1.3
—
—
—
0
0
352
3320
1.74
2.34
5.5
4.9
2.88
2.84
mmol/l
0.32
340
3084
23
120
1.98
2.31
1.2
1.1
—
—
—
0
0
347
3263
1.67
2.30
4.8
4.3
4.82
4.80
mmol/l
0.11
337
3041
54
364
1.56
2.26
4.7
6.1
104.00
103.87
mmol/l
0.07
54
364
23
121
1.96
2.26
1.3
1.1
—
—
—
0
0
341
3196
1.61
2.25
5.2
4.4
6.07
5.89
mmol/l
2.18
327
2925
46
299
1.61
2.24
4.8
7.3
4.91
5.13
kpa
1.06
46
289
46
299
1.61
2.24
4.7
7.2
10.99
11.99
kpa
0.98
46
290
159
1317
1.35
2.20
4.7
4.1
36.15
35.78
g/l
0.45
151
1229
111
877
1.37
2.05
2.6
2.9
1057.97
1086.14
ng/l
0.03
101
748
66
476
1.47
2.03
2.1
1.8
—
—
—
0
0
9
32
2.85
2.01
1.3
1.1
—
—
—
0
0
16
77
2.12
1.99
1.6
1.4
—
—
—
0
0
45
300
1.57
1.99
4.9
7.2
0.56
1.41
mmol/l
0.94
35
249
134
1102
1.33
1.89
3.6
2.9
—
—
—
0
0
9
34
2.69
1.87
1.7
1.4
—
—
—
0
0
371
3589
2.08
1.75
25.3
19.1
39.45
40.04
%
0.90
346
3390
8
31
2.61
1.67
1.3
1.0
—
—
—
0
0
6
19
3.19
1.66
1.0
1.1
—
—
—
0
0
27
167
1.66
1.63
6.3
8.7
93.80
94.27
%
0.23
27
167
5
14
3.60
1.62
1.2
1.4
—
—
—
0
0
221
1983
1.27
1.51
3.0
2.9
—
—
—
0
0
8
166
0.47
1.51
5.9
2.9
5.26
5.19
kpa
—
8
160
73
566
1.36
1.50
1.9
1.6
1123.15
1276.33
nmol/l
0.94
61
409
108
887
1.30
1.50
1.7
1.6
1.55
1.37
mmol/l
1.37
97
747
15
80
1.91
1.46
1.3
1.2
—
—
—
0
0
142
1215
1.27
1.43
4.3
3.8
—
—
—
0
0
15
82
1.86
1.37
1.1
1.1
—
—
—
0
0
15
82
1.86
1.37
1.3
1.4
202.40
282.17
mu/l
2.21
15
76
103
851
1.29
1.36
3.3
2.8
0.54
0.49
e6/l
0.09
80
621
328
3115
1.37
1.35
13.8
12.0
80.77
80.48
ml/min/173m2
0.09
274
2544
10
47
2.16
1.35
1.1
1.3
—
—
—
0
0
108
902
1.27
1.31
3.2
3.5
6.32
7.27
mg/mmol
0.10
62
561
68
536
1.33
1.27
1.4
1.4
—
—
—
0
0
26
172
1.55
1.24
1.4
1.3
—
—
—
0
0
5
19
2.65
1.22
4.2
2.5
477.20
545.32
e6/l
—
5
19
16
94
1.73
1.19
1.9
1.7
—
—
—
0
0
338
3243
1.36
1.14
4.7
4.3
1.46
1.54
mmol/l
3.18
327
3006
328
3137
1.32
1.10
4.2
3.9
1.46
1.28
mmol/l
4.80
317
2882
16
97
1.68
1.08
1.4
1.4
1.17
1.18
g/l
0.03
16
92
27
187
1.48
1.07
1.8
1.6
—
—
—
0
0
7
33
2.14
1.06
1.1
1.2
—
—
—
0
0
18
116
1.58
0.98
1.8
2.2
—
—
—
0
0
7
37
1.91
0.94
1.0
1.1
—
—
—
0
0
12
70
1.74
0.93
1.5
1.4
—
—
—
0
0
12
70
1.74
0.93
1.5
1.4
—
—
—
0
0
89
756
1.23
0.93
2.7
2.0
—
—
—
0
0
15
94
1.62
0.92
1.9
1.4
189.67
331.35
ug/g
—
9
48
8
44
1.84
0.86
1.1
1.1
—
—
—
0
0
15
96
1.59
0.85
1.7
1.6
—
—
—
0
0
13
81
1.63
0.82
1.5
1.1
—
—
—
0
0
28
207
1.38
0.82
2.4
1.6
—
—
—
0
0
74
633
1.21
0.73
1.4
1.4
—
—
—
0
0
22
297
0.72
0.73
1.5
1.8
—
—
—
0
0
7
39
1.81
0.73
1.0
1.1
—
—
—
0
0
13
84
1.57
0.73
1.9
2.3
10.38
12.00
mg/l
0.67
13
77
74
634
1.21
0.72
2.5
2.8
2.43
2.45
mmol/l
1.28
63
556
34
267
1.30
0.70
1.7
2.6
71.31
61.44
ml/min/173m2
1.11
16
103
5
27
1.86
0.68
1.0
1.6
1.11
1.05
g/l
—
5
27
5
29
1.73
0.64
1.0
1.0
—
—
—
0
0
25
191
1.33
0.62
1.3
1.3
—
—
—
0
0
5
30
1.68
0.61
3.2
2.2
—
—
—
0
0
0
21
0.00
0.60
0.0
2.1
—
0.20
—
0
10
0
22
0.00
0.59
0.0
2.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.8
—
—
—
0
0
45
375
1.23
0.59
10.7
6.2
—
—
—
0
0
31
384
0.79
0.58
4.4
4.2
28.54
32.65
%
1.51
24
245
15
109
1.39
0.51
1.5
1.8
—
—
—
0
0
225
2146
1.12
0.48
2.9
2.8
51.07
46.24
u/l
0.30
213
2012
5
83
0.60
0.46
1.0
1.2
—
—
—
0
0
11
77
1.44
0.46
2.4
2.4
—
—
—
0
0
27
221
1.24
0.43
1.2
1.2
105.79
155.63
iu/ml
—
10
105
6
94
0.63
0.42
1.8
1.2
—
36.28
—
0
5
74
667
1.14
0.41
1.8
1.6
379.12
13493976.28
pmol/l
0.50
68
541
32
269
1.21
0.41
3.2
3.1
2.95
2.08
mmol/l
0.36
23
231
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
27
224
1.22
0.39
1.4
3.0
32.83
58.16
u/ml
0.56
27
218
5
37
1.36
0.37
3.0
3.9
—
—
—
0
0
41
357
1.17
0.37
3.7
3.9
2.55
28.78
ug/l
0.77
34
294
6
41
1.47
0.36
1.0
1.8
—
—
—
0
0
5
78
0.64
0.36
1.0
1.4
—
—
—
0
0
10
73
1.38
0.35
1.3
1.2
—
—
—
0
0
10
73
1.38
0.35
2.4
1.3
—
—
—
0
0
6
47
1.28
0.32
1.0
1.1
—
—
—
0
0
9
72
1.26
0.26
1.2
1.1
3.78
3.85
mmol/l
—
9
64
21
244
0.85
0.25
2.3
1.7
—
—
—
0
0
12
97
1.24
0.23
1.7
1.6
—
—
—
0
0
5
39
1.29
0.23
1.0
1.1
—
—
—
0
0
120
1145
1.07
0.22
3.0
3.3
2.35
2.36
mmol/l
0.49
111
1005
5
42
1.19
0.21
5.8
1.9
—
—
—
0
0
6
51
1.18
0.19
1.3
1.2
—
—
—
0
0
7
58
1.21
0.18
4.7
1.9
—
—
—
0
0
88
838
1.07
0.18
4.6
3.8
0.00
0.00
estimate
-0.00
23
289
6
76
0.79
0.15
1.7
1.7
—
—
—
0
0
29
316
0.91
0.15
3.8
3.3
—
—
—
0
0
12
103
1.17
0.14
1.8
1.9
0.89
3.91
ug/l
0.61
12
96
16
142
1.13
0.13
3.7
2.9
70.10
1404.92
u/ml
—
10
121
5
44
1.14
0.10
5.8
1.9
—
—
—
0
0
5
44
1.14
0.10
5.8
1.9
—
—
—
0
0
5
44
1.14
0.10
2.0
1.5
—
—
—
0
0
5
44
1.14
0.10
1.0
1.2
6.74
7.63
mmol/l
—
5
35
5
47
1.06
0.09
1.4
3.7
68.80
59.47
%
—
5
47
6
54
1.11
0.09
1.3
1.5
—
—
—
0
0
6
56
1.07
0.08
1.7
1.8
—
—
—
0
0
10
113
0.88
0.08
4.3
1.9
—
—
—
0
0
26
244
1.07
0.08
5.4
6.1
8.97
8.99
mmol/l
0.01
26
230
7
65
1.08
0.08
4.4
1.8
—
—
—
0
0
25
266
0.94
0.08
2.2
1.9
—
—
—
0
0
6
71
0.84
0.07
1.5
1.1
—
—
—
0
0
31
324
0.95
0.05
2.4
2.7
0.67
0.75
ug/l
0.31
22
207
13
121
1.08
0.03
1.8
1.7
—
—
—
0
0
56
548
1.03
0.03
4.4
4.5
1.62
2.65
ug/l
1.00
51
498
10
108
0.92
0.03
1.8
1.7
—
—
—
0
0
18
172
1.05
0.02
1.0
1.0
—
—
—
0
0
15
144
1.04
0.00
1.9
2.0
0.53
0.65
%
0.89
15
144
14
137
1.02
0.00
1.4
1.4
—
—
—
0
0
26
265
0.98
0.00
2.3
3.8
1.24
1.23
mmol/l
0.24
26
228
43
435
0.99
0.00
4.4
4.2
25.39
21.48
%
0.90
17
204
15
146
1.03
0.00
1.9
2.0
1.11
1.11
%
0.01
15
146
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
1.20
—
0
5
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
108.00
—
0
5
5
59
0.85
0.00
5.2
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
12
120
1.00
-0.00
1.6
1.4
—
—
—
0
0
5
53
0.94
-0.00
1.4
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
60
1.00
-0.00
1.2
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
8.30
—
0
8
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_TARSTUN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_TARSTUN | 0.804 [0.66, 0.97] | 0.026 |
| Birth year | 0.994 [0.99, 1.0] | 0.166 |
During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 1139 females with G6_TARSTUN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_TARSTUN | 0.961 [0.76, 1.22] | 0.747 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 501 males with G6_TARSTUN died.
Mortality risk
Mortality risk for people of age
years, who have G6_TARSTUN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.078% | 0.209% |
| 5 | 0.458% | 1.193% |
| 10 | 1.154% | 2.996% |
| 15 | 2.191% | 5.581% |
| 20 | 4.018% | 9.683% |
Relationships between endpoints
↥Index endpoint: G6_TARSTUN – Tarsal tunnel syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data