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Tarsal tunnel syndrome

DOID EFO Endpoint Browser PheWeb

G6_TARSTUN

tarsal tunnel syndrome: Tarsal tunnel syndrome is a nerve disorder that is characterized by pain in the ankle, foot, and toes. This condition is caused by compression of the posterior tibial nerve, which runs through a canal near the heel into the sole of the foot. When tissues around this nerve become inflamed, they can press on the nerve and cause the pain associated with tarsal tunnel syndrome.

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Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G57.5
  • Hospital discharge: ICD-9 — 3555
  • Cause of death: ICD-10 — G57.5
  • Cause of death: ICD-9 — 3555

2 out of 7 registries used, show all original rules.

367

4. Check minimum number of events

None

367

5. Include endpoints

None

367

6. Filter based on genotype QC (FinnGen only)

367

Control definitions (FinnGen only)

Control exclude
G6_NERPLEX

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G57
Name in latin
Syndroma canalis tarsi

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2313 1573 732
Only index persons 2188 1518 670
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.02
Only index persons 0.05 0.06 0.03
Median age at first event (years)
Whole population 50.86 51.67 49.08
Only index persons 50.63 51.61 48.43

-FinnGen-

Key figures

All Female Male
Number of individuals 367 279 88
Unadjusted period prevalence (%) 0.08 0.10 0.04
Median age at first event (years) 51.19 50.96 51.92

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
332
Matched controls
3318
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G57.5
ICD-10 Finland
Tarsal tunnel syndrome
10047.1
323.0
289
*
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
327.2
114.7
110
5
3555A
ICD-9 Finland
Mononeuritis of lower limb, Tarsal tunnel syndrome
+∞
53.6
50
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
18.1
45.2
72
50
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
133.0
44.0
46
*
ACC51
NOMESCO Finland
Release of median nerve
188.7
33.4
34
*
N03AX16
ATC
pregabalin; oral
4.5
30.8
137
448
G57.6
ICD-10 Finland
Lesion of plantar nerve
45.2
24.0
29
7
N02AX02
ATC
tramadol; systemic, rectal
3.3
23.4
186
929
N03AX12
ATC
gabapentin; oral
4.6
23.2
92
257
ACC55
NOMESCO Finland
Release of tibial nerve
+∞
18.9
18
*
M79.6
ICD-10 Finland
Pain in limb
2.9
18.3
161
814
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.8
18.1
191
1078
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
4.6
16.3
60
152
M77.4
ICD-10 Finland
Metatarsalgia
6.2
16.3
45
82
M54.4
ICD-10 Finland
Lumbago with sciatica
3.6
15.6
79
267
M01AH05
ATC
etoricoxib; oral
2.6
14.7
231
1557
M01AC06
ATC
meloxicam; systemic, rectal
2.5
14.5
162
905
A02BC03
ATC
lansoprazole; oral
2.6
13.8
127
630
L16
ICPC
Ankle symptom/complaint
3.9
13.4
58
170
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
3.4
13.3
69
236
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.8
12.7
93
402
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
4.5
12.4
45
112
M01AX17
ATC
nimesulide; oral
2.6
12.2
107
513
M25.5
ICD-10 Finland
Pain in joint
2.5
12.1
122
628
N06AX21
ATC
duloxetine; oral
3.6
11.7
55
173
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.3
11.3
59
202
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.5
11.2
54
173
M01AH02
ATC
rofecoxib; oral
3.0
11.1
70
272
N02AJ06
ATC
codeine and paracetamol; systemic
2.3
11.1
138
784
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
6.9
11.0
27
42
XA402
NOMESCO Finland
ENMG
12.5
11.0
19
16
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
10.7
134
762
M03BX02
ATC
tizanidine; oral
2.2
10.6
230
1667
NHM10
NOMESCO Finland
Fasciotomy of ankle or foot
33.7
10.4
13
*
L17
ICPC
Foot/toe symptom/complaint
2.4
10.2
104
532
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
11.1
9.9
18
17
M48.0
ICD-10 Finland
Spinal stenosis
3.1
9.9
56
202
NHL50
NOMESCO Finland
Tenolysis or tenosynovectomy of foot
27.0
9.9
13
5
M01AB05
ATC
diclofenac; systemic, rectal
2.2
9.9
239
1790
M77.1
ICD-10 Finland
Lateral epicondylitis
4.0
9.8
39
106
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
9.7
146
890
A02BC02
ATC
pantoprazole; systemic
2.1
9.5
234
1748
M02AA07
ATC
piroxicam; topical
2.1
9.5
147
906
M01AE02
ATC
naproxen; oral, rectal
2.1
9.4
203
1431
ZXA00
NOMESCO Finland
Right side
2.3
9.2
105
563
N02BE01
ATC
paracetamol; systemic, rectal
2.7
9.1
297
2508
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
9.9
8.9
17
18
J01DA01
ATC
[U] cefalexin; systemic
2.1
8.8
224
1666
M01AX05
ATC
glucosamine; oral
2.3
8.5
91
469
G57.8
ICD-10 Finland
Other mononeuropathies of lower limb
+∞
8.4
8
*
G57.4
ICD-10 Finland
Lesion of medial popliteal nerve
+∞
8.4
8
*
WX320
NOMESCO Finland
Spinalanesthesy
2.3
8.3
86
438
L03
ICPC
Low back symptom/complaint
2.2
8.2
95
507
N06AA09
ATC
amitriptyline; systemic
2.9
8.0
50
192
H02AB06
ATC
prednisolone; systemic
2.0
8.0
165
1115
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
3.0
7.7
45
167
E66.8
ICD-10 Finland
Other obesity
4.3
7.6
27
67
J01FA10
ATC
azithromycin; systemic
1.9
7.6
208
1545
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
7.5
79
403
ACC19
NOMESCO Finland
Transcision of peripheral nerve: other or unspecified
81.8
7.4
8
*
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
3.8
7.4
30
84
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
4.0
7.4
28
74
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
6.5
7.3
18
29
L11
ICPC
Wrist symptom/complaint
3.5
7.1
32
98
J01AA02
ATC
doxycycline; systemic
2.1
7.0
268
2220
M03BC51
ATC
orphenadrine, combinations; systemic
2.0
7.0
107
637
A02BA02
ATC
ranitidine; systemic
2.2
7.0
78
407
SPAT1216
SPAT
Assessment of functional ability
2.4
7.0
59
270
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.0
7.0
21
44
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
4.1
7.0
26
68
L28
ICPC
Limited function/disability (L)
2.4
6.9
61
285
M70.6
ICD-10 Finland
Trochanteric bursitis
2.5
6.8
55
246
J01FF01
ATC
clindamycin; systemic
2.0
6.8
99
580
R52.9
ICD-10 Finland
Pain, unspecified
3.1
6.7
35
120
R06.0
ICD-10 Finland
Dyspnoea
2.0
6.7
94
542
M54.5
ICD-10 Finland
Low back pain
1.9
6.7
115
715
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.1
6.6
84
463
J01DB01
ATC
cefalexin; oral
2.1
6.6
273
2295
N02AA05
ATC
oxycodone; systemic
2.5
6.5
51
226
G51.0
ICD-10 Finland
Bell palsy
71.2
6.4
7
*
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.9
6.4
107
655
3540A
ICD-9 Finland
Mononeuritis of upper limb and mononeuritis multiplex, Carpal tunnel syndrome
+∞
6.3
6
*
M76.6
ICD-10 Finland
Achilles tendinitis
3.8
6.2
25
70
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.8
6.2
39
150

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
229
1729
1.86
7.50
4.0
4.1
7.0
6.6
mmol/l
1.14
215
1618
175
1242
1.78
6.79
2.2
1.9
94.9
97.1
pmol/l
0.27
91
585
89
511
1.98
6.76
1.4
1.3
13.9
14.0
u/ml
0.00
39
207
109
680
1.86
6.42
4.1
3.6
—
—
—
0
0
186
1362
1.74
6.33
5.0
3.7
—
—
—
0
0
60
306
2.15
6.24
1.6
1.5
—
—
—
0
0
94
566
1.89
6.15
4.8
3.6
268.3
258.7
ng/l
0.02
72
431
130
879
1.74
5.75
1.8
2.1
137.0
164.5
u/l
0.94
120
823
196
1486
1.68
5.65
4.5
3.7
0.0
0.0
estimate
0.00
20
279
290
2460
1.85
5.46
4.6
4.1
14.7
14.9
pmol/l
0.77
281
2226
156
1143
1.63
4.93
3.9
3.5
—
—
—
0
0
195
1510
1.62
4.92
5.8
5.0
0.0
0.0
estimate
0.00
21
275
264
2214
1.69
4.76
4.1
3.7
—
—
—
0
0
339
3076
2.34
4.68
17.1
12.9
20.2
22.5
mg/l
0.72
289
2362
195
1524
1.60
4.64
4.7
3.7
0.0
0.0
estimate
0.80
21
275
95
621
1.71
4.60
6.1
4.2
1.0
1.0
kg/l
0.61
18
74
279
2388
1.70
4.51
7.7
7.0
78.6
77.8
u/l
0.09
273
2236
65
385
1.84
4.39
1.6
1.9
—
—
—
0
0
102
692
1.66
4.27
1.7
1.6
1.6
1.0
mg/l
0.47
84
529
131
946
1.60
4.26
2.7
2.2
50.0
57.0
u/l
1.59
126
864
35
170
2.17
4.12
1.4
1.2
—
—
—
0
0
151
1135
1.56
4.10
3.6
3.4
65.0
28.7
ng/l
0.59
96
780
83
544
1.68
3.94
1.3
1.2
19.9
33.6
iu/ml
0.84
27
191
321
2895
1.87
3.89
5.7
4.9
1.9
2.3
mu/l
0.53
316
2644
61
369
1.78
3.84
2.9
2.1
18.5
23.1
%
1.57
51
322
25
109
2.39
3.78
1.2
1.1
—
—
—
0
0
187
1495
1.51
3.72
5.8
5.9
1.2
1.2
mmol/l
0.32
170
1264
198
1607
1.50
3.63
5.8
5.8
10.3
10.9
umol/l
0.37
190
1521
351
3299
2.47
3.29
19.3
15.1
71.9
73.7
umol/l
0.48
351
3299
153
1197
1.48
3.26
12.7
8.3
1.4
1.2
inr
1.10
42
366
35
187
1.96
3.23
3.3
2.8
—
—
—
0
0
170
1362
1.46
3.19
5.1
5.0
1.2
1.2
mmol/l
0.16
161
1234
241
2067
1.48
3.16
5.2
4.2
—
—
—
0
0
61
391
1.67
3.12
1.3
1.3
493.3
557.6
titre
0.15
12
85
41
235
1.84
3.08
5.0
7.6
121.0
121.2
g/l
0.02
41
229
100
724
1.52
3.08
1.6
1.5
20.3
21.8
nmol/l
0.46
90
611
104
762
1.51
3.02
2.1
2.5
3434.0
8469.0
umol/l
0.74
95
651
182
1489
1.44
3.00
6.5
5.4
0.0
0.0
e9/l
0.05
160
1272
184
1515
1.43
2.89
6.7
5.4
1.9
1.9
e9/l
0.15
167
1324
93
674
1.51
2.83
1.2
1.2
0.8
2.1
u/ml
1.09
32
186
23
112
2.12
2.73
1.3
1.2
—
—
—
0
0
179
1482
1.41
2.65
6.6
5.4
0.6
0.6
e9/l
0.24
157
1270
46
286
1.70
2.64
4.7
7.1
11.0
11.9
kpa
0.82
46
278
46
286
1.70
2.64
4.8
7.1
4.9
5.1
kpa
1.09
46
277
21
100
2.17
2.64
2.0
4.7
1.5
1.5
%
0.05
21
95
159
1296
1.40
2.56
3.2
2.6
121.5
108.2
ug/l
0.23
152
1189
122
954
1.42
2.47
6.1
5.5
—
—
—
0
0
50
324
1.63
2.47
2.4
2.4
7.2
8.1
umol/l
0.17
43
282
9
27
3.39
2.41
1.2
1.1
—
—
—
0
0
94
706
1.45
2.36
2.6
2.0
3.2
3.1
mg/l
0.07
80
598
23
119
2.00
2.36
2.7
1.8
—
—
—
0
0
182
1532
1.37
2.35
6.7
5.8
0.2
0.2
e9/l
0.23
166
1334
45
288
1.64
2.33
4.9
7.0
0.6
1.5
mmol/l
0.91
35
235
97
735
1.43
2.32
4.4
4.1
—
—
—
0
0
14
59
2.43
2.32
1.9
2.1
—
—
—
0
0
55
376
1.54
2.18
31.2
23.9
1.5
1.3
inr
—
7
52
204
1763
1.35
2.16
8.6
9.1
4.0
4.0
e9/l
0.16
186
1530
154
1277
1.35
2.13
4.7
4.0
36.1
35.8
g/l
0.34
146
1190
340
3221
1.76
2.13
15.9
12.1
—
—
—
0
0
35
215
1.69
2.13
1.3
1.2
—
—
—
0
0
23
125
1.90
2.08
7.0
8.2
—
—
—
0
0
25
140
1.84
2.06
3.0
3.8
—
—
—
0
0
103
806
1.39
2.03
7.1
6.6
—
—
—
0
0
165
1390
1.34
2.03
6.9
5.6
2.8
2.7
%
0.08
159
1288
122
982
1.36
2.03
4.3
2.8
—
—
—
0
0
19
98
1.99
1.99
2.6
2.6
—
—
—
0
0
117
939
1.36
1.97
4.0
3.7
7.4
7.4
ph
0.11
12
180
332
3136
1.62
1.97
4.9
4.4
4.8
4.8
mmol/l
0.02
322
2914
7
21
3.38
1.97
1.4
1.2
—
—
—
0
0
27
159
1.75
1.91
6.3
8.5
93.8
94.2
%
0.19
27
159
160
1352
1.33
1.90
7.0
5.6
0.7
0.7
%
0.02
154
1250
167
1420
1.32
1.90
7.0
5.8
29.0
27.8
%
0.82
159
1322
166
1412
1.32
1.87
6.9
5.5
57.0
57.5
%
0.22
160
1318
164
1394
1.32
1.86
7.4
5.9
8.6
8.5
%
0.05
157
1301
336
3193
1.62
1.81
5.6
4.9
2.9
2.8
mmol/l
0.19
324
2956
116
942
1.34
1.79
3.2
2.1
—
—
—
0
0
14
67
2.13
1.78
3.0
5.6
1.3
1.3
mmol/l
0.11
14
58
7
162
0.42
1.71
6.6
2.9
5.3
5.2
kpa
—
7
148
15
76
2.02
1.66
2.1
3.7
3.8
3.9
mmol/l
0.42
15
69
44
305
1.50
1.66
1.5
1.6
—
—
—
0
0
311
2921
1.42
1.65
6.6
5.4
40.3
39.5
mmol/mol
0.87
301
2722
25
151
1.70
1.64
2.3
4.2
—
—
—
0
0
325
3078
1.49
1.64
5.2
4.4
6.1
5.9
mmol/l
2.29
311
2810
5
14
3.61
1.62
1.8
1.6
146.6
156.7
nmol/l
—
5
14
5
14
3.61
1.62
1.2
7.6
—
—
—
0
0
8
32
2.53
1.60
1.0
1.2
—
—
—
0
0
6
20
3.03
1.58
1.3
1.4
—
—
—
0
0
103
836
1.32
1.58
3.0
3.0
25.9
195.9
mg/l
0.92
68
524
19
107
1.82
1.58
21.8
9.6
—
—
—
0
0
5
16
3.15
1.44
4.6
1.4
—
—
—
0
0
5
16
3.15
1.44
1.0
1.9
—
—
—
0
0
107
884
1.30
1.43
3.4
3.7
6.4
7.1
mg/mmol
0.07
61
551
50
367
1.42
1.43
2.2
2.1
67.2
113.0
ug/g
1.65
35
289
107
886
1.29
1.41
2.7
2.9
7.1
7.0
mmol/l
0.05
93
753
9
41
2.22
1.38
1.3
1.1
—
—
—
0
0
19
306
0.60
1.36
1.3
1.4
—
—
—
0
0
30
201
1.54
1.35
2.0
2.4
—
—
—
0
0
98
807
1.29
1.34
3.4
2.8
—
—
—
0
0
93
763
1.29
1.31
1.3
1.3
—
—
—
0
0
70
552
1.33
1.31
2.0
1.6
1130.4
1286.0
nmol/l
0.92
59
396
104
866
1.28
1.30
1.7
1.6
1.6
1.4
mmol/l
1.52
94
730
73
580
1.32
1.29
1.3
1.6
2.4
2.4
g/l
0.05
41
348
5
18
2.80
1.29
1.2
6.2
—
—
—
0
0
5
117
0.42
1.27
7.6
2.6
—
—
—
0
0
9
45
2.02
1.24
1.3
1.6
—
—
—
0
0
107
901
1.26
1.22
3.3
2.9
65.4
145.6
e6/l
0.49
85
678
15
248
0.59
1.21
2.9
3.6
—
—
—
0
0
14
80
1.78
1.14
1.9
3.4
—
—
—
0
0
325
3118
1.37
1.12
4.7
4.3
1.5
1.5
mmol/l
3.49
314
2880
123
1064
1.23
1.10
4.0
3.5
80.9
92.8
e6/l
0.14
92
743
13
74
1.78
1.08
1.3
1.5
204.8
278.1
mu/l
1.68
13
69
11
191
0.56
1.07
1.6
1.5
—
—
—
0
0
56
441
1.32
1.07
1.3
1.2
—
—
—
0
0
32
231
1.42
1.04
2.1
2.5
—
11.4
—
0
9
30
214
1.44
1.03
1.5
1.3
—
—
—
0
0
97
823
1.24
1.03
3.4
2.8
0.5
0.5
e6/l
0.04
76
598
74
609
1.27
1.02
2.5
2.8
2.4
2.4
mmol/l
1.18
63
532
315
3018
1.31
1.01
4.2
3.9
1.5
1.3
mmol/l
4.36
304
2767
9
48
1.90
1.01
1.3
1.3
57.0
63.1
mmol/l
—
9
40
5
23
2.19
0.98
1.6
1.0
—
—
—
0
0
36
270
1.37
0.95
3.3
3.0
—
—
—
0
0
13
78
1.69
0.92
1.9
2.4
10.4
12.2
mg/l
0.79
13
71
76
893
0.81
0.86
4.4
3.6
—
—
—
0
0
28
205
1.40
0.86
1.1
1.3
—
33.2
—
0
9
105
1192
0.83
0.84
2.7
2.8
—
—
—
0
0
21
292
0.70
0.81
1.2
1.4
—
—
—
0
0
68
573
1.23
0.78
2.5
2.7
504.3
527.3
mosm/kgh2o
0.45
61
485
23
166
1.41
0.77
2.7
2.4
—
—
—
0
0
6
34
1.78
0.76
1.0
1.3
251.3
297.3
pmol/l
—
6
26
5
24
2.10
0.75
1.0
1.6
1.1
1.0
g/l
—
5
24
30
229
1.34
0.74
7.1
6.8
—
—
—
0
0
14
92
1.54
0.73
1.7
1.4
208.1
328.9
ug/g
—
8
47
9
56
1.62
0.73
1.1
1.3
—
—
—
0
0
7
40
1.76
0.71
1.0
1.0
—
—
—
0
0
7
40
1.76
0.71
1.1
1.1
—
—
—
0
0
43
349
1.26
0.69
1.8
1.4
—
—
—
0
0
5
28
1.80
0.66
3.8
1.9
—
—
—
0
0
5
28
1.80
0.66
3.2
2.3
—
—
—
0
0
30
235
1.30
0.63
3.6
3.3
—
—
—
0
0
30
235
1.30
0.63
4.2
4.5
0.3
0.1
%
—
6
65
11
72
1.54
0.59
2.1
2.0
—
—
—
0
0
9
61
1.49
0.54
1.3
5.1
—
—
—
0
0
11
74
1.50
0.54
1.1
1.3
—
—
—
0
0
11
74
1.50
0.54
1.1
1.3
—
—
—
0
0
11
74
1.50
0.54
1.1
1.3
—
—
—
0
0
9
63
1.44
0.52
1.1
1.1
—
—
—
0
0
26
207
1.28
0.51
1.2
1.2
105.8
146.4
iu/ml
—
10
96
31
253
1.25
0.50
4.1
4.3
1.3
0.9
%
—
7
75
10
67
1.51
0.50
1.1
1.3
—
—
—
0
0
10
67
1.51
0.50
3.3
1.5
3590.1
22169.7
e6/l
—
10
52
12
84
1.44
0.50
1.8
2.7
0.2
0.2
g/l
—
6
28
13
93
1.41
0.49
1.3
1.2
—
—
—
0
0
41
348
1.20
0.47
3.7
3.9
2.5
29.5
ug/l
0.77
34
286
41
348
1.20
0.47
1.1
1.3
—
—
—
0
0
7
48
1.47
0.47
1.4
1.4
—
—
—
0
0
27
220
1.25
0.45
1.4
3.1
32.8
58.7
u/ml
0.57
27
215
7
51
1.38
0.44
1.0
1.0
—
—
—
0
0
69
617
1.15
0.43
2.4
2.4
3.9
7.1
e6/l
1.47
63
549
5
31
1.62
0.43
1.2
1.9
—
—
—
0
0
5
31
1.62
0.43
1.0
1.2
—
—
—
0
0
31
259
1.22
0.42
3.3
3.0
2.9
2.1
mmol/l
0.31
22
220
14
105
1.35
0.41
3.1
3.8
—
—
—
0
0
0
15
0.00
0.41
0.0
3.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
31.9
—
0
16
16
123
1.31
0.41
1.1
1.2
—
—
—
0
0
45
391
1.17
0.41
2.0
1.7
—
—
—
0
0
0
17
0.00
0.40
0.0
23.4
—
1787.2
—
0
17
0
17
0.00
0.40
0.0
16.6
—
906.7
—
0
17
72
649
1.14
0.40
1.8
1.6
380.6
13852439.7
pmol/l
0.50
66
527
148
1392
1.11
0.40
10.7
9.1
0.0
0.0
e9/l
0.38
123
1137
287
2795
1.12
0.38
20.9
14.0
39.1
39.9
%
0.73
213
2063
33
281
1.19
0.38
4.9
3.5
—
—
—
0
0
9
68
1.33
0.38
2.3
2.6
1.7
1.5
mmol/l
—
9
68
9
70
1.29
0.37
1.2
1.1
3.8
3.8
mmol/l
—
9
62
6
42
1.44
0.35
1.3
1.2
—
—
—
0
0
6
42
1.44
0.35
1.5
1.5
—
—
—
0
0
6
44
1.37
0.34
2.0
1.7
—
—
—
0
0
25
210
1.20
0.33
1.2
1.3
—
—
—
0
0
32
276
1.17
0.33
1.9
1.5
—
—
—
0
0
10
74
1.36
0.32
1.1
1.3
—
—
—
0
0
117
1104
1.09
0.29
3.0
3.2
2.4
2.4
mmol/l
0.36
107
961
8
110
0.72
0.29
1.5
1.6
—
—
—
0
0
90
842
1.09
0.27
3.9
3.3
—
—
—
0
0
28
244
1.16
0.26
1.3
1.4
—
—
—
0
0
72
673
1.09
0.23
4.2
4.4
—
—
—
0
0
16
135
1.19
0.22
3.7
2.8
69.6
1487.9
u/ml
—
10
114
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
85
803
1.08
0.21
4.7
3.9
0.0
0.0
estimate
0.00
21
274
36
326
1.12
0.21
1.8
1.5
—
—
—
0
0
5
43
1.16
0.21
1.4
3.2
5.3
4.9
e9/l
—
5
43
21
183
1.16
0.20
1.9
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
2.4
—
1455.7
—
0
14
6
51
1.18
0.19
1.5
1.7
64.5
57.3
%
—
6
51
26
232
1.13
0.19
5.4
5.7
9.0
9.0
mmol/l
0.00
26
218
6
52
1.16
0.19
1.3
1.5
—
—
—
0
0
21
185
1.14
0.18
2.1
1.6
—
—
—
0
0
7
61
1.15
0.17
2.7
2.7
6.6
7.7
mmol/l
—
7
61
12
101
1.19
0.17
1.8
1.8
0.9
4.2
ug/l
0.67
12
95
8
69
1.16
0.16
1.1
1.8
—
—
—
0
0
11
92
1.20
0.16
1.0
1.1
—
—
—
0
0
24
216
1.12
0.16
2.1
3.4
82.2
74.8
e9/l
0.29
19
164
31
286
1.09
0.14
1.2
1.5
—
—
—
0
0
133
1297
1.04
0.11
2.0
2.0
—
—
—
0
0
29
311
0.93
0.11
2.5
2.8
0.7
0.8
ug/l
0.12
20
196
5
45
1.11
0.10
1.4
3.8
68.8
59.7
%
—
5
45
5
46
1.09
0.09
1.0
1.8
1.4
0.8
g/l
—
5
37
5
64
0.78
0.08
1.6
1.3
—
—
—
0
0
8
75
1.07
0.07
5.1
5.6
—
—
—
0
0
13
140
0.93
0.04
1.2
1.1
—
—
—
0
0
15
141
1.07
0.03
1.9
2.0
1.1
1.1
%
0.02
15
141
19
182
1.05
0.02
1.4
1.4
—
—
—
0
0
26
254
1.03
0.00
2.3
3.9
1.2
1.2
mmol/l
0.22
26
220
40
394
1.02
0.00
1.2
1.2
—
—
—
0
0
5
58
0.86
0.00
2.0
2.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
5
50
1.00
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
3.6
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
1.2
—
0
6
5
55
0.91
0.00
1.6
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
3818.8
—
0
5
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
106.8
—
0
7
0
9
0.00
0.00
0.0
12.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
4.8
—
—
—
0
0
5
50
1.00
0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint G6_TARSTUN and mortality.

Females

Parameter HR [95% CI] p-value
G6_TARSTUN 0.804 [0.66, 0.97] 0.026
Birth year 0.994 [0.99, 1.0] 0.166

During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 1139 females with G6_TARSTUN died.

Males

Parameter HR [95% CI] p-value
G6_TARSTUN 0.961 [0.76, 1.22] 0.747
Birth year 0.989 [0.98, 1.0] 0.019

During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 501 males with G6_TARSTUN died.

Mortality risk

Mortality risk for people of age

years, who have G6_TARSTUN.

N-year risk Females Males
1 0.078% 0.209%
5 0.458% 1.193%
10 1.154% 2.996%
15 2.191% 5.581%
20 4.018% 9.683%

Relationships between endpoints

↥

Index endpoint: G6_TARSTUN – Tarsal tunnel syndrome

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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