No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
275 |
4. Check minimum number of eventsNone |
275 |
5. Include endpointsNone |
275 |
6. Filter based on genotype QC (FinnGen only) |
275 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H04
- Name in latin
- Dacryoadenitis
Similar endpoints
↥List of similar endpoints to
Dacryoadenitis
based on the number of shared cases.
Similar with more cases:
- Disorders of lacrimal system
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2212 | 1511 | 693 |
| Only index persons | 1950 | 1344 | 606 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 53.96 | 56.86 | 47.52 |
| Only index persons | 51.95 | 55.26 | 44.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 275 | 192 | 83 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.04 |
| Median age at first event (years) | 53.43 | 52.49 | 55.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 248
- Matched controls
- 2479
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H04.0
ICD-10 Finland
Dacryoadenitis
16384.0
293.2
221
*
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
+∞
69.0
63
*
H04.4
ICD-10 Finland
Chronic inflammation of lacrimal passages
+∞
47.4
44
*
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
+∞
45.2
42
*
H04.3
ICD-10 Finland
Acute and unspecified inflammation of lacrimal passages
396.5
34.8
34
*
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
182.6
31.5
32
*
H04.10
ICD-10 Finland
Dry eye syndrome
12.8
30.5
56
55
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.5
19.7
138
647
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.4
17.6
119
528
36800
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Dacryadenitis acuta. Abscessus glandulae lacrimalis
+∞
15.8
15
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.9
14.9
69
223
TCC30
NOMESCO Finland
Intubation of lacrimal canaliculus/duct
+∞
14.7
14
*
CCD50
NOMESCO Finland
Dacryocystorhinostomy with insertion of tube
+∞
14.7
14
*
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
158.8
14.6
15
*
H02.4
ICD-10 Finland
Ptosis of eyelid
125.5
11.5
12
*
H57.1
ICD-10 Finland
Ocular pain
16.0
11.5
18
12
UDH02
NOMESCO Finland
Rhinopharyngoscopy
5.9
11.0
31
59
H01.0
ICD-10 Finland
Blepharitis
6.8
10.8
27
44
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
6.3
10.6
28
49
H02AB06
ATC
prednisolone; systemic
2.5
10.6
139
845
S01GX01
ATC
cromoglicic acid; ophthalmic
3.0
10.2
67
274
H02.3
ICD-10 Finland
Blepharochalasis
57.2
9.7
11
*
ZXA00
NOMESCO Finland
Right side
2.5
9.1
84
416
H16.0
ICD-10 Finland
Corneal ulcer
7.1
8.9
21
32
J01DB01
ATC
cefalexin; oral
2.8
8.6
213
1703
36801
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Dacryadenitis chronica
+∞
8.4
8
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
6.3
7.9
20
34
36802
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Obstructio, stenosis viarum lacrimalium
+∞
7.3
7
*
UDM02
NOMESCO Finland
Sinoscopy
8.3
7.2
15
19
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.6
7.0
31
95
F29
ICPC
Eye symptom/complaint other
3.8
6.9
28
80
R01AD08
ATC
fluticasone; nasal
2.2
6.6
79
434
A05AA02
ATC
ursodeoxycholic acid; oral
10.4
6.6
12
12
ZXE00
NOMESCO Finland
One hour or less
2.0
6.6
110
696
H04.2
ICD-10 Finland
Epiphora
71.6
6.5
7
*
CCA30
NOMESCO Finland
Incision of lacrimal sac
+∞
6.3
6
*
CCD40
NOMESCO Finland
Percutaneous dacryocystorhinostomy
+∞
6.3
6
*
H02.2
ICD-10 Finland
Lagophthalmos
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint H7_DACRYOADENITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DACRYOADENITIS | 1.049 [0.86, 1.27] | 0.633 |
| Birth year | 0.995 [0.99, 1.0] | 0.239 |
During the follow-up period (1.1.1998 — 31.12.2019), 219 out of 1134 females with H7_DACRYOADENITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DACRYOADENITIS | 1.041 [0.76, 1.42] | 0.798 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 509 males with H7_DACRYOADENITIS died.
Mortality risk
Mortality risk for people of age
years, who have H7_DACRYOADENITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.087% | 0.212% |
| 5 | 0.568% | 1.1% |
| 10 | 1.448% | 2.794% |
| 15 | 2.876% | 5.216% |
| 20 | 5.457% | 8.913% |
Relationships between endpoints
↥Index endpoint: H7_DACRYOADENITIS – Dacryoadenitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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