No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
275 |
4. Check minimum number of eventsNone |
275 |
5. Include endpointsNone |
275 |
6. Filter based on genotype QC (FinnGen only) |
275 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H04
- Name in latin
- Dacryoadenitis
Similar endpoints
↥List of similar endpoints to
Dacryoadenitis
based on the number of shared cases.
Similar with more cases:
- Disorders of lacrimal system
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2212 | 1511 | 693 |
| Only index persons | 1950 | 1344 | 606 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 53.96 | 56.86 | 47.52 |
| Only index persons | 51.95 | 55.26 | 44.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 275 | 192 | 83 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.04 |
| Median age at first event (years) | 53.43 | 52.49 | 55.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 248
- Matched controls
- 2479
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H04.0
ICD-10 Finland
Dacryoadenitis
16384.0
293.2
221
*
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
+∞
69.0
63
*
H04.4
ICD-10 Finland
Chronic inflammation of lacrimal passages
+∞
47.4
44
*
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
+∞
45.2
42
*
H04.3
ICD-10 Finland
Acute and unspecified inflammation of lacrimal passages
396.5
34.8
34
*
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
182.6
31.5
32
*
H04.10
ICD-10 Finland
Dry eye syndrome
12.8
30.5
56
55
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.5
19.7
138
647
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.4
17.6
119
528
36800
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Dacryadenitis acuta. Abscessus glandulae lacrimalis
+∞
15.8
15
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.9
14.9
69
223
TCC30
NOMESCO Finland
Intubation of lacrimal canaliculus/duct
+∞
14.7
14
*
CCD50
NOMESCO Finland
Dacryocystorhinostomy with insertion of tube
+∞
14.7
14
*
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
158.8
14.6
15
*
H02.4
ICD-10 Finland
Ptosis of eyelid
125.5
11.5
12
*
H57.1
ICD-10 Finland
Ocular pain
16.0
11.5
18
12
UDH02
NOMESCO Finland
Rhinopharyngoscopy
5.9
11.0
31
59
H01.0
ICD-10 Finland
Blepharitis
6.8
10.8
27
44
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
6.3
10.6
28
49
H02AB06
ATC
prednisolone; systemic
2.5
10.6
139
845
S01GX01
ATC
cromoglicic acid; ophthalmic
3.0
10.2
67
274
H02.3
ICD-10 Finland
Blepharochalasis
57.2
9.7
11
*
ZXA00
NOMESCO Finland
Right side
2.5
9.1
84
416
H16.0
ICD-10 Finland
Corneal ulcer
7.1
8.9
21
32
J01DB01
ATC
cefalexin; oral
2.8
8.6
213
1703
36801
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Dacryadenitis chronica
+∞
8.4
8
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
6.3
7.9
20
34
36802
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Obstructio, stenosis viarum lacrimalium
+∞
7.3
7
*
UDM02
NOMESCO Finland
Sinoscopy
8.3
7.2
15
19
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.6
7.0
31
95
F29
ICPC
Eye symptom/complaint other
3.8
6.9
28
80
R01AD08
ATC
fluticasone; nasal
2.2
6.6
79
434
A05AA02
ATC
ursodeoxycholic acid; oral
10.4
6.6
12
12
H04.2
ICD-10 Finland
Epiphora
71.6
6.5
7
*
CCA30
NOMESCO Finland
Incision of lacrimal sac
+∞
6.3
6
*
CCD40
NOMESCO Finland
Percutaneous dacryocystorhinostomy
+∞
6.3
6
*
H02.2
ICD-10 Finland
Lagophthalmos
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
215
1665
2.34
7.88
5.9
3.8
12.0
12.6
mm/h
0.29
203
1525
19
49
4.09
6.83
1.5
1.6
0.1
0.0
iu/ml
—
7
9
71
387
2.13
6.45
1.3
1.3
19.8
37.0
iu/ml
1.29
18
128
214
1715
2.12
6.28
9.4
6.8
77.8
76.9
u/l
0.11
205
1606
122
814
1.90
6.20
3.9
3.1
—
—
—
0
0
69
380
2.09
6.07
1.3
1.3
2.8
10.3
u/ml
1.86
29
156
15
39
4.01
5.33
4.5
3.5
3.7
4.6
e9/l
1.07
15
39
15
40
3.91
5.16
5.1
4.1
52.9
61.6
%
1.87
15
40
22
77
3.02
5.05
2.0
1.8
—
192.0
—
0
5
149
1118
1.73
4.71
4.9
3.7
0.0
0.0
estimate
0.00
32
209
148
1110
1.72
4.67
5.9
4.9
0.0
0.0
estimate
0.00
35
221
86
557
1.79
4.54
2.4
2.1
3.0
3.1
mg/l
0.26
76
470
146
1100
1.70
4.46
4.9
3.7
0.0
0.0
estimate
0.00
35
221
7
6
11.92
4.30
1.1
1.0
—
—
—
0
0
129
954
1.66
4.13
6.3
4.1
35.2
35.5
g/l
0.26
121
894
160
1268
1.63
3.77
11.2
8.4
3.8
4.1
e9/l
1.42
145
1114
31
150
2.20
3.74
2.0
1.6
—
—
—
0
0
233
2054
1.88
3.53
5.8
4.7
1.7
1.9
mu/l
2.13
219
1872
89
618
1.65
3.53
6.0
4.0
0.0
0.0
estimate
0.00
32
222
141
1096
1.59
3.51
6.4
6.3
1.2
1.2
mmol/l
0.29
118
925
77
517
1.68
3.47
1.5
1.2
2.3
1.8
u/ml
0.12
24
126
251
2278
2.17
3.36
21.3
15.6
4.0
4.0
mmol/l
1.50
244
2207
201
1717
1.63
3.22
5.0
4.0
14.8
14.9
pmol/l
0.12
187
1556
250
2274
2.09
3.19
21.1
15.6
139.4
139.7
mmol/l
0.87
245
2207
10
29
3.54
3.07
1.4
1.7
—
—
—
0
0
245
2223
1.94
2.99
19.5
13.6
21.4
23.6
mg/l
0.44
209
1723
18
76
2.46
2.96
2.5
1.7
—
—
—
0
0
90
651
1.57
2.95
3.6
2.9
0.3
0.4
e6/l
0.30
70
484
113
865
1.52
2.85
5.4
3.8
—
—
—
0
0
120
935
1.50
2.76
2.6
2.3
81.9
76.7
nmol/l
1.19
112
832
59
394
1.63
2.67
1.6
1.6
—
—
—
0
0
255
2364
2.08
2.63
13.7
9.6
24.7
24.4
u/l
0.13
248
2275
16
68
2.44
2.61
2.6
1.3
—
—
—
0
0
13
50
2.68
2.57
2.1
1.6
—
—
—
0
0
125
993
1.47
2.56
3.9
2.7
111.4
113.1
ug/l
0.04
118
907
5
7
7.25
2.56
1.0
1.0
1735.4
1745.0
miu/ml
—
5
7
6
11
5.55
2.55
5.3
1.7
—
—
—
0
0
39
237
1.75
2.49
2.2
1.8
—
—
—
0
0
126
1007
1.46
2.48
6.5
5.1
1.2
1.2
mmol/l
0.21
118
919
13
51
2.63
2.48
1.8
1.6
—
—
—
0
0
8
22
3.71
2.38
1.0
1.0
—
—
—
0
0
51
339
1.62
2.34
2.1
1.8
—
—
—
0
0
38
235
1.72
2.29
2.1
1.7
—
—
—
0
0
238
2181
1.68
2.26
5.1
4.7
2.8
2.7
mmol/l
0.17
222
1998
69
499
1.51
2.20
2.5
1.7
0.7
1.1
mg/l
1.69
52
390
48
320
1.61
2.18
2.8
1.8
29.3
29.5
s
0.08
48
311
13
56
2.39
2.08
2.8
3.0
—
—
—
0
0
233
2140
1.58
2.00
4.4
4.2
4.7
4.7
mmol/l
0.00
216
1972
7
21
3.39
1.98
3.6
1.2
—
—
—
0
0
5
11
4.61
1.95
2.6
3.8
108.8
99.7
%
—
5
11
6
16
3.81
1.94
1.8
3.6
—
—
—
0
0
89
695
1.41
1.89
3.4
2.3
57.8
55.8
u/l
0.17
81
648
10
40
2.56
1.85
1.7
1.2
—
—
—
0
0
10
40
2.56
1.85
1.7
1.2
—
—
—
0
0
5
12
4.22
1.83
1.0
2.9
355.8
1040.0
u/ml
—
5
12
140
1185
1.37
1.82
7.2
5.7
10.9
10.8
umol/l
0.03
134
1131
11
48
2.35
1.73
1.4
1.4
—
—
—
0
0
70
535
1.41
1.66
2.6
2.8
8922.8
9213.4
umol/l
0.02
59
462
7
25
2.85
1.66
1.3
1.8
—
—
—
0
0
15
77
2.00
1.62
1.7
1.2
3.8
3.8
g/l
—
10
58
10
43
2.38
1.62
1.4
1.5
—
—
—
0
0
79
621
1.38
1.59
3.0
3.2
1288.6
1608.5
ng/l
0.35
64
525
6
20
3.04
1.59
1.3
1.9
—
—
—
0
0
6
20
3.04
1.59
1.3
2.0
—
—
—
0
0
6
20
3.04
1.59
1.3
2.0
—
—
—
0
0
15
78
1.98
1.57
1.7
1.2
6.5
7.6
g/l
—
10
62
15
78
1.98
1.57
1.7
1.2
—
—
—
0
0
30
194
1.61
1.56
8.0
3.0
1.6
2.2
mmol/l
0.58
23
152
12
59
2.08
1.46
1.9
4.4
42.5
149.0
mg/l
—
7
45
12
59
2.08
1.46
1.9
4.4
26.5
24.4
mg/l
—
7
45
5
16
3.16
1.44
6.4
1.6
417.2
627.5
e6/l
—
5
11
6
22
2.76
1.44
1.0
1.2
—
—
—
0
0
11
53
2.12
1.40
1.0
1.1
—
—
—
0
0
228
2127
1.42
1.39
4.4
4.2
1.5
1.5
mmol/l
0.46
210
1957
5
17
2.98
1.36
1.4
1.5
—
—
—
0
0
29
193
1.56
1.36
5.7
7.0
119.7
120.0
g/l
0.03
29
185
9
42
2.18
1.35
1.3
1.6
—
—
—
0
0
225
2098
1.40
1.34
15.8
12.7
80.1
81.0
ml/min/173m2
0.21
179
1717
61
473
1.37
1.32
4.9
4.5
2.4
2.9
ug/l
0.26
53
419
6
24
2.53
1.31
1.5
1.7
—
—
—
0
0
6
24
2.53
1.31
1.3
1.2
—
—
—
0
0
6
24
2.53
1.31
1.3
1.2
—
—
—
0
0
227
2122
1.40
1.31
5.0
4.4
5.8
5.9
mmol/l
0.72
208
1932
59
456
1.37
1.31
1.8
1.8
478.2
17678544.3
pmol/l
0.50
48
379
13
69
1.93
1.31
1.8
1.4
—
—
—
0
0
18
107
1.73
1.29
1.1
1.0
—
—
—
0
0
161
1437
1.29
1.27
4.6
2.9
47.8
45.1
u/l
0.15
155
1347
0
33
0.00
1.17
0.0
1.2
—
—
—
0
0
5
20
2.53
1.15
1.2
1.2
—
—
—
0
0
5
20
2.53
1.15
1.2
1.2
—
—
—
0
0
12
65
1.88
1.15
1.3
1.1
—
—
—
0
0
12
65
1.88
1.15
1.3
1.1
—
—
—
0
0
104
890
1.27
1.11
2.1
1.9
96.9
96.2
pmol/l
0.04
57
460
5
21
2.41
1.09
1.2
1.2
—
—
—
0
0
5
21
2.41
1.09
1.2
1.2
—
—
—
0
0
5
21
2.41
1.09
1.2
1.2
—
—
—
0
0
47
363
1.36
1.05
3.7
4.1
24.1
21.6
%
0.48
26
168
69
565
1.30
1.04
1.7
1.6
1.3
1.4
mmol/l
0.26
57
473
5
22
2.30
1.04
1.0
1.8
—
—
—
0
0
5
22
2.30
1.04
2.4
1.9
—
—
—
0
0
219
2059
1.31
1.03
4.0
3.8
1.3
1.3
mmol/l
0.08
202
1887
7
131
0.52
1.02
1.6
1.5
—
—
—
0
0
7
35
2.03
1.00
1.0
1.1
—
—
—
0
0
28
200
1.45
0.98
5.5
4.9
1.2
1.3
mmol/l
0.18
28
185
9
50
1.83
0.97
1.8
1.3
—
—
—
0
0
9
51
1.79
0.95
1.0
1.5
—
—
—
0
0
213
2002
1.28
0.95
6.3
5.5
40.0
39.8
mmol/mol
0.07
203
1861
52
415
1.31
0.95
1.9
1.8
1187.9
1190.2
nmol/l
0.01
47
308
20
134
1.53
0.94
5.6
7.4
24.2
24.5
mmol/l
0.11
20
123
20
134
1.53
0.94
1.5
1.9
—
—
—
0
0
31
228
1.41
0.94
3.7
3.4
—
—
—
0
0
24
168
1.47
0.93
1.6
1.2
412.4
142.5
iu/ml
—
10
71
10
55
1.85
0.93
1.7
1.1
—
—
—
0
0
120
1065
1.22
0.90
4.5
3.9
—
—
—
0
0
24
170
1.45
0.89
2.2
2.5
59.3
65.6
ml/min/173m2
—
10
71
24
170
1.45
0.89
1.6
2.0
—
—
—
0
0
28
210
1.37
0.77
3.4
2.2
119.1
30.7
u/l
0.59
21
171
0
28
0.00
0.76
0.0
1.3
—
7.6
—
0
21
9
53
1.72
0.76
1.1
1.5
—
—
—
0
0
149
1367
1.20
0.75
3.6
3.1
—
—
—
0
0
5
24
2.10
0.75
2.4
1.8
—
—
—
0
0
9
145
0.61
0.71
2.7
3.7
5.1
5.0
kpa
—
9
133
5
26
1.94
0.71
1.0
1.1
—
—
—
0
0
81
707
1.21
0.70
4.4
2.9
35.0
30.3
u/l
0.37
74
678
11
69
1.62
0.69
1.2
1.2
—
—
—
0
0
17
119
1.46
0.68
1.3
1.3
—
—
—
0
0
7
43
1.64
0.67
2.1
1.4
—
—
—
0
0
62
529
1.22
0.67
2.8
2.1
—
—
—
0
0
85
759
1.17
0.56
3.1
3.2
2.4
2.4
mmol/l
0.55
78
670
34
278
1.25
0.54
3.1
2.8
0.6
0.9
ug/l
0.97
21
188
9
61
1.49
0.54
1.7
1.3
—
—
—
0
0
6
39
1.55
0.53
2.5
1.6
—
—
—
0
0
92
832
1.16
0.52
5.3
3.7
29.7
82.8
ng/l
0.67
62
573
21
267
0.77
0.50
2.9
4.4
30.1
31.7
%
0.35
15
176
15
110
1.38
0.50
3.6
2.4
1.2
1.3
%
0.12
15
110
208
2000
1.16
0.48
20.9
14.2
39.4
39.7
%
0.20
161
1447
48
418
1.18
0.43
4.7
3.7
652.1
240.5
ng/l
0.32
35
322
43
371
1.19
0.43
3.4
2.8
4.4
3.6
e6/l
0.19
25
192
45
390
1.18
0.43
1.8
1.4
—
—
—
0
0
5
31
1.62
0.43
2.4
1.4
—
—
—
0
0
5
31
1.62
0.43
2.0
1.9
—
—
—
0
0
30
250
1.22
0.42
6.9
2.5
7.3
8.2
umol/l
0.11
24
215
0
17
0.00
0.41
0.0
1.5
—
—
—
0
0
12
88
1.38
0.40
2.4
2.0
0.5
1.6
ug/l
1.18
12
77
34
290
1.20
0.39
2.4
2.2
—
—
—
0
0
0
19
0.00
0.39
0.0
3.8
—
—
—
0
0
9
66
1.38
0.39
2.3
2.0
—
—
—
0
0
10
72
1.40
0.37
1.7
2.1
—
—
—
0
0
6
43
1.40
0.35
2.7
1.6
—
—
—
0
0
44
391
1.15
0.32
3.1
2.5
0.8
1.1
e6/l
0.64
25
208
28
242
1.17
0.29
5.9
6.3
11.8
12.7
kpa
0.48
28
230
28
242
1.17
0.29
5.9
6.3
5.2
5.1
kpa
0.28
28
228
30
263
1.16
0.27
2.1
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
480.1
—
0
7
0
13
0.00
0.21
0.0
1.1
—
44.0
—
0
7
0
14
0.00
0.20
0.0
1.9
—
7.6
—
0
7
55
513
1.09
0.19
1.8
1.5
19.5
21.7
nmol/l
0.56
50
437
14
122
1.16
0.14
1.5
1.7
—
—
—
0
0
16
178
0.89
0.11
1.6
1.7
—
—
—
0
0
14
124
1.14
0.11
1.2
1.4
—
—
—
0
0
26
243
1.08
0.09
2.8
4.4
13.1
24.9
ug/l
0.28
19
206
27
253
1.07
0.09
13.5
7.2
—
—
—
0
0
7
68
1.03
0.08
1.6
1.2
—
—
—
0
0
6
75
0.80
0.07
1.3
1.4
—
—
—
0
0
9
86
1.05
0.07
2.1
2.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
15
150
1.00
0.00
3.8
2.8
52.0
53.6
u/ml
0.02
15
145
8
81
0.99
0.00
1.9
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.84
0.00
1.2
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
24.1
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint H7_DACRYOADENITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DACRYOADENITIS | 1.049 [0.86, 1.27] | 0.633 |
| Birth year | 0.995 [0.99, 1.0] | 0.239 |
During the follow-up period (1.1.1998 — 31.12.2019), 219 out of 1134 females with H7_DACRYOADENITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DACRYOADENITIS | 1.041 [0.76, 1.42] | 0.798 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 509 males with H7_DACRYOADENITIS died.
Mortality risk
Mortality risk for people of age
years, who have H7_DACRYOADENITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.087% | 0.212% |
| 5 | 0.568% | 1.1% |
| 10 | 1.448% | 2.794% |
| 15 | 2.876% | 5.216% |
| 20 | 5.457% | 8.913% |
Relationships between endpoints
↥Index endpoint: H7_DACRYOADENITIS – Dacryoadenitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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