cardiomyopathy: A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
224 |
4. Check minimum number of eventsNone |
224 |
5. Include endpointsNone |
224 |
6. Filter based on genotype QC (FinnGen only) |
224 |
Control definitions (FinnGen only)
- Control exclude
- I9_OTHHEART
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Cardiomyopathies, Secondary/extrinsic
based on the number of shared cases.
Similar with more cases:
- Cardiomyopathy (excluding other)
- Cardiomyopathy
- Other heart diseases
- Other heart diseases, wide
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4781 | 746 | 3926 |
| Only index persons | 2094 | 381 | 1713 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.02 | 0.11 |
| Only index persons | 0.06 | 0.01 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 56.51 | 59.10 | 55.87 |
| Only index persons | 58.60 | 60.45 | 58.19 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 224 | 65 | 159 |
| Unadjusted period prevalence (%) | 0.06 | 0.02 | 0.07 |
| Median age at first event (years) | 60.19 | 55.59 | 62.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 200
- Matched controls
- 1998
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I42.6
ICD-10 Finland
Alcoholic cardiomyopathy
+∞
156.5
129
*
I50.9
ICD-10 Finland
Heart failure, unspecified
319.7
94.4
89
5
I42.0
ICD-10 Finland
Dilated cardiomyopathy
+∞
88.2
78
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
119.6
77.2
80
11
I42.7
ICD-10 Finland
Cardiomyopathy due to drugs and other external agents
+∞
71.1
64
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
69.3
58.7
66
14
I50.1
ICD-10 Finland
Left ventricular failure
+∞
54.7
50
*
I50.0
ICD-10 Finland
Congestive heart failure
330.4
51.6
50
*
C01AA05
ATC
digoxin; systemic
55.0
50.4
59
15
C03CA01
ATC
furosemide; systemic
10.9
49.0
118
233
C03DA01
ATC
spironolactone; oral
18.4
46.0
75
63
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
+∞
43.3
40
*
207
Kela drug reimbursment
Chronic arrhythmias
460.1
39.5
38
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
112.7
35.0
37
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
9.7
31.3
70
105
B01AA03
ATC
warfarin; systemic
9.6
29.7
66
97
C07AB07
ATC
bisoprolol; oral
5.7
29.3
127
466
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
+∞
27.7
26
*
I47.2
ICD-10 Finland
Ventricular tachycardia
+∞
23.4
22
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
258.0
23.1
23
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
258.0
23.1
23
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
22.3
21
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
5.8
21.9
72
177
K78
ICPC
Atrial fibrillation/flutter
30.9
20.6
27
10
C09DX04
ATC
valsartan and sacubitril; oral
+∞
20.1
19
*
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
+∞
20.1
19
*
C09AA05
ATC
ramipril; oral
4.5
19.4
85
280
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.9
19.4
60
135
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
8.1
19.1
45
69
C01BD01
ATC
amiodarone; systemic
208.5
18.9
19
*
TFP20
NOMESCO Finland
Cardiodefibrillation
73.5
18.1
20
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
9.9
17.1
35
42
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
+∞
15.8
15
*
XF400
NOMESCO Finland
ECG with 12 standard connections
4.8
15.8
58
155
381
Kela drug reimbursment
Combination product containing sacubitril and valsartan
+∞
14.8
14
*
K70.0
ICD-10 Finland
Alcoholic fatty liver
24.5
14.5
20
9
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.9
14.3
50
126
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
12.2
13.4
24
22
I44.7
ICD-10 Finland
Left bundle-branch block, unspecified
+∞
12.6
12
*
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
138.1
12.6
13
*
GD1LA
NOMESCO Finland
GD
138.1
12.6
13
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
9.2
12.5
26
32
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
24.6
11.8
16
7
AN1
HP
Coronary angiography
4.7
11.1
39
97
P15
ICPC
Chronic alcohol abuse
11.5
10.5
19
18
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
115.7
10.5
11
*
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
115.7
10.5
11
*
N07BB01
ATC
disulfiram; oral
7.3
9.8
23
35
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
18.6
9.5
14
8
A12BA01
ATC
potassium chloride; oral
10.3
9.5
18
19
FPG96
NOMESCO Finland
Other implantation of permanent cardioverter-defibrillator
+∞
9.4
9
*
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
+∞
9.4
9
*
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
+∞
9.4
9
*
A98
ICPC
Health maint/preventive medicine
0.4
9.2
124
1634
K77
ICPC
Heart failure
38.5
9.1
11
*
Z2221
NOMESCO Finland
Medical doctor
2.9
9.0
62
264
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
14.9
8.8
14
10
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
14.9
8.8
14
10
R56.8
ICD-10 Finland
Other and unspecified convulsions
7.0
8.7
21
33
F10.20
ICD-10 Finland
Alcohol dependence currently independent
12.3
8.7
15
13
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
+∞
8.4
8
*
I48.1
ICD-10 Finland
Persistent atrial fibrillation
+∞
8.4
8
*
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
+∞
8.4
8
*
FPE96
NOMESCO Finland
Other implantation or replacement of transvenous cardiac pacemaker
+∞
8.4
8
*
4258A
ICD-9 Finland
Cardiomyopathy in other diseases classified elsewhere
+∞
8.4
8
*
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
+∞
8.4
8
*
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
+∞
8.4
8
*
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
12.4
8.2
14
12
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
23.1
8.1
11
5
TPH07
NOMESCO Finland
Cathetrisation of artery
4.3
8.1
30
79
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
8.1
64
295
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
9.0
8.0
16
19
F10.25
ICD-10 Finland
Alcohol dependence continuous use
10.0
7.9
15
16
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
7.8
90
509
F10.24
ICD-10 Finland
Alcohol depence active use
12.5
7.7
13
11
ZX120
NOMESCO Finland
Intravenous
4.2
7.5
28
74
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.2
7.5
41
148
C07AB02
ATC
metoprolol; systemic
2.9
7.4
49
202
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
11.5
7.4
13
12
I42.8
ICD-10 Finland
Other cardiomyopathies
+∞
7.3
7
*
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
+∞
7.3
7
*
1CX08
NOMESCO Finland
NA
+∞
7.3
7
*
N05CF01
ATC
zopiclone; oral
2.4
7.2
75
396
115
Kela drug reimbursment
Breast cancer
5.3
7.2
21
43
I47.1
ICD-10 Finland
Supraventricular tachycardia
31.2
7.2
9
*
Z3231
NOMESCO Finland
Registered nurse
2.5
7.2
62
299
C07AA07
ATC
sotalol; systemic
10.6
7.1
13
13
F10.09
ICD-10 Finland
Alcohol intoxication UNS
10.6
7.1
13
13
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
10.6
7.1
13
13
XF404
NOMESCO Finland
Ambulatory ECG
6.3
7.1
18
31
B01AF02
ATC
apixaban; oral
8.0
7.0
15
20
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
14.4
7.0
11
8
N05BA02
ATC
chlordiazepoxide; systemic
8.7
6.9
14
17
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
7.6
6.8
15
21
XFE00
NOMESCO Finland
Epicardial ultrasonography
23.4
6.7
9
*
M04AA01
ATC
allopurinol; systemic
3.2
6.7
37
134
L03AA02
ATC
filgrastim; parenteral
6.6
6.6
16
26
N05BA04
ATC
oxazepam; oral
2.6
6.6
54
250
R06.0
ICD-10 Finland
Dyspnoea
2.6
6.5
51
231
T36
ICD-10 Finland
Poisoning by systemic antibiotics
6.3
6.4
16
27
XF640
NOMESCO Finland
NA
11.5
6.4
11
10
I42.1
ICD-10 Finland
Obstructive hypertrophic cardiomyopathy
+∞
6.3
6
*
TFP30
NOMESCO Finland
Cathetric examination for cardiac arrythmia
+∞
6.3
6
*
FPJ24
NOMESCO Finland
Revision of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
+∞
6.3
6
*
I44.2
ICD-10 Finland
Atrioventricular block, complete
+∞
6.3
6
*
2000B
ICD-9 Finland
Lymphosarcoma and reticulosarcoma, Reticulosarcoma[LYMPHOMA MALIGNUM DIFFUSUM]
+∞
6.3
6
*
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
+∞
6.3
6
*
I50
ICD-10 Finland
Heart failure
27.6
6.3
8
*
K70.4
ICD-10 Finland
Alcoholic hepatic failure
27.6
6.3
8
*
WX892
NOMESCO Finland
Monitored bed care
4.5
6.2
21
51
N05AA02
ATC
levomepromazine; systemic
4.9
6.2
19
42
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMSEC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMSEC | 6.432 [4.18, 9.9] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.206 |
During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 233 females with I9_CARDMSEC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMSEC | 7.233 [5.83, 8.98] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 480 out of 782 males with I9_CARDMSEC died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMSEC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.612% | 1.675% |
| 5 | 3.985% | 8.275% |
| 10 | 9.404% | 18.906% |
| 15 | 17.163% | 33.051% |
| 20 | 27.778% | 49.542% |
Relationships between endpoints
↥Index endpoint: I9_CARDMSEC – Cardiomyopathies, Secondary/extrinsic
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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