cardiomyopathy: A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
254 |
4. Check minimum number of eventsNone |
254 |
5. Include endpointsNone |
254 |
6. Filter based on genotype QC (FinnGen only) |
249 |
Control definitions (FinnGen only)
- Control exclude
- I9_OTHHEART
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Cardiomyopathies, Secondary/extrinsic
based on the number of shared cases.
Similar with more cases:
- Cardiomyopathy (excluding other)
- Cardiomyopathy
- Other heart diseases
- Other heart diseases, wide
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4781 | 746 | 3926 |
| Only index persons | 2094 | 381 | 1713 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.02 | 0.11 |
| Only index persons | 0.06 | 0.01 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 56.51 | 59.10 | 55.87 |
| Only index persons | 58.60 | 60.45 | 58.19 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 249 | 72 | 177 |
| Unadjusted period prevalence (%) | 0.07 | 0.03 | 0.08 |
| Median age at first event (years) | 60.61 | 57.22 | 61.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 254
- Matched controls
- 2540
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I42.6
ICD-10 Finland
Alcoholic cardiomyopathy
+∞
206.5
169
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
134.6
194.2
99
12
I48
ICD-10 Finland
Atrial fibrillation and flutter
97.8
160.3
85
13
C01AA05
ATC
digoxin; systemic
54.3
115.4
68
17
I50.9
ICD-10 Finland
Heart failure, unspecified
275.6
115.2
110
7
I42.0
ICD-10 Finland
Dilated cardiomyopathy
+∞
107.0
95
*
C03DA01
ATC
spironolactone; oral
18.4
103.7
99
85
I42.7
ICD-10 Finland
Cardiomyopathy due to drugs and other external agents
+∞
86.5
78
*
I50.1
ICD-10 Finland
Left ventricular failure
937.2
74.1
69
*
C03CA01
ATC
furosemide; systemic
9.4
73.7
145
314
I50.0
ICD-10 Finland
Congestive heart failure
793.9
64.9
61
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
9.5
59.6
88
134
207
Kela drug reimbursment
Chronic arrhythmias
693.9
58.1
55
*
B01AA03
ATC
warfarin; systemic
8.6
49.2
76
120
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
+∞
48.5
45
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
8.8
45.2
66
97
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
45.2
42
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
41.8
39
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
162.1
40.0
41
*
C07AB07
ATC
bisoprolol; oral
5.4
38.6
163
634
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
8.8
30.7
42
56
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.3
30.4
77
192
C09AA05
ATC
ramipril; oral
4.5
30.0
109
363
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
169.3
29.3
30
*
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
+∞
28.7
27
*
C09DX04
ATC
valsartan and sacubitril; oral
+∞
28.7
27
*
TFP20
NOMESCO Finland
Cardiodefibrillation
+∞
28.7
27
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
288.3
26.2
26
*
P15
ICPC
Chronic alcohol abuse
9.8
26.0
32
37
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.1
25.9
66
164
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
9.9
25.6
31
35
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
4.3
24.6
84
262
381
Kela drug reimbursment
Combination product containing sacubitril and valsartan
+∞
23.3
22
*
K78
ICPC
Atrial fibrillation/flutter
23.5
23.3
33
16
I47.2
ICD-10 Finland
Ventricular tachycardia
251.8
23.0
23
*
XF400
NOMESCO Finland
ECG with 12 standard connections
4.4
22.4
70
203
K70.0
ICD-10 Finland
Alcoholic fatty liver
48.0
21.9
26
6
C01BD01
ATC
amiodarone; systemic
108.1
18.8
20
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
6.5
18.4
32
55
N07BB01
ATC
disulfiram; oral
6.4
18.1
32
56
XF404
NOMESCO Finland
Ambulatory ECG
8.2
17.3
24
32
F10.25
ICD-10 Finland
Alcohol dependence continuous use
16.9
16.6
26
17
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
+∞
15.8
15
*
250, ,
Kela drug reimbursment
+∞
15.8
15
*
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
21.8
15.4
22
11
AN1
HP
Coronary angiography
4.4
15.0
42
110
I48.1
ICD-10 Finland
Persistent atrial fibrillation
+∞
14.7
14
*
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
158.8
14.6
15
*
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
158.8
14.6
15
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.5
14.6
61
212
I44.7
ICD-10 Finland
Left bundle-branch block, unspecified
79.5
13.7
15
*
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
17.5
13.7
21
13
B01AF02
ATC
apixaban; oral
10.6
13.6
26
27
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
147.6
13.6
14
*
GD1LA
NOMESCO Finland
GD
147.6
13.6
14
*
WX892
NOMESCO Finland
Monitored bed care
5.1
13.4
30
65
K77
ICPC
Heart failure
42.5
13.3
16
*
TPH07
NOMESCO Finland
Cathetrisation of artery
4.0
13.2
42
121
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
20.4
13.1
19
10
N05AA02
ATC
levomepromazine; systemic
6.1
12.7
23
41
I48.2
ICD-10 Finland
Chronic atrial fibrillation
+∞
12.6
12
*
F10.24
ICD-10 Finland
Alcohol depence active use
15.4
12.5
20
14
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
12.5
130
732
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
22.6
12.2
17
8
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
14.4
12.2
20
15
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
49.1
12.0
14
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
12.0
86
402
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
12.7
11.5
20
17
I42.8
ICD-10 Finland
Other cardiomyopathies
+∞
11.5
11
*
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
+∞
11.5
11
*
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
11.3
11.5
21
20
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
22.7
10.8
15
7
N05CD07
ATC
temazepam; oral
3.4
10.8
44
149
I50
ICD-10 Finland
Heart failure
62.7
10.7
12
*
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
+∞
10.5
10
*
FPG96
NOMESCO Finland
Other implantation of permanent cardioverter-defibrillator
+∞
10.5
10
*
I47.1
ICD-10 Finland
Supraventricular tachycardia
41.8
10.1
12
*
ZX120
NOMESCO Finland
Intravenous
3.4
9.8
38
124
M04AA01
ATC
allopurinol; systemic
3.0
9.5
47
178
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
+∞
9.4
9
*
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
+∞
9.4
9
*
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
+∞
9.4
9
*
F10.20
ICD-10 Finland
Alcohol dependence currently independent
8.3
9.3
20
26
F10.09
ICD-10 Finland
Alcohol intoxication UNS
8.8
9.2
19
23
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
38.2
9.1
11
*
C07AA07
ATC
sotalol; systemic
14.7
8.8
14
10
N05CF01
ATC
zopiclone; oral
2.3
8.8
94
518
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
20.9
8.6
12
6
A98
ICPC
Health maint/preventive medicine
0.4
8.5
175
2132
L03AA02
ATC
filgrastim; parenteral
4.9
8.5
19
41
N05BA01
ATC
diazepam; systemic, rectal
2.9
8.5
43
165
1CX08, ,
NOMESCO Finland
93.0
8.5
9
*
Z2221
NOMESCO Finland
Medical doctor
2.4
8.5
78
402
ZXD05
NOMESCO Finland
Urgent procedure
2.3
8.4
79
410
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
7.5
8.4
19
27
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.0
8.4
25
68
FPE96
NOMESCO Finland
Other implantation or replacement of transvenous cardiac pacemaker
+∞
8.4
8
*
I44.2
ICD-10 Finland
Atrioventricular block, complete
+∞
8.4
8
*
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
+∞
8.4
8
*
4258A
ICD-9 Finland
Cardiomyopathy in other diseases classified elsewhere
+∞
8.4
8
*
Z3231
NOMESCO Finland
Registered nurse
2.3
8.2
80
421
A12BA01
ATC
potassium chloride; oral
7.2
8.2
19
28
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.0
7.8
23
62
K70.4
ICD-10 Finland
Alcoholic hepatic failure
46.4
7.8
9
*
R06.0
ICD-10 Finland
Dyspnoea
2.3
7.7
69
349
N05BA04
ATC
oxazepam; oral
2.3
7.7
74
386
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
25.9
7.6
10
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.5
7.6
19
45
XF640, ,
NOMESCO Finland
13.9
7.5
12
9
FPJ24
NOMESCO Finland
Revision of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
+∞
7.3
7
*
FPE37
NOMESCO Finland
Implantation of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
+∞
7.3
7
*
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
+∞
7.3
7
*
JN4BD
NOMESCO Finland
Extensive body CT
2.8
7.3
39
154
N05BA02
ATC
chlordiazepoxide; systemic
6.9
7.2
17
26
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.0
7.2
19
34
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.3
7.2
19
47
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.9
7.2
35
131
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.5
7.2
25
76
127
Kela drug reimbursment
Transplant complication
14.3
7.0
11
8
A10BK01
ATC
dapagliflozin; oral
3.4
6.9
25
78
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
11.4
6.9
12
11
L04AA01
ATC
[U] ciclosporin
41.2
6.8
8
*
I35.0
ICD-10 Finland
Aortic (valve) stenosis
41.2
6.8
8
*
C07AB02
ATC
metoprolol; systemic
2.4
6.8
52
245
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.8
6.7
18
33
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
8.2
6.7
14
18
E87.6
ICD-10 Finland
Hypokalaemia
4.4
6.7
17
41
Z72.1
ICD-10 Finland
Alcohol use
12.7
6.6
11
9
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
6.6
39
162
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
6.5
6.6
16
26
A46
ICD-10 Finland
Erysipelas
2.5
6.6
43
188
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
7.7
6.5
14
19
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
5.5
6.5
18
35
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
71.6
6.5
7
*
K92.0
ICD-10 Finland
Haematemesis
7.3
6.3
14
20
I42
ICD-10 Finland
Cardiomyopathy
+∞
6.3
6
*
I49.0
ICD-10 Finland
Ventricular fibrillation and flutter
+∞
6.3
6
*
2000B
ICD-9 Finland
Lymphosarcoma and reticulosarcoma, Reticulosarcoma[LYMPHOMA MALIGNUM DIFFUSUM]
+∞
6.3
6
*
I42.1
ICD-10 Finland
Obstructive hypertrophic cardiomyopathy
+∞
6.3
6
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
6.0
6.3
16
28
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
8.9
6.1
12
14
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
72
196
4.73
25.22
3.3
1.9
22.47
25.05
%
0.65
64
178
53
125
5.09
21.89
15.9
4.9
12.18
8.67
mmol/l
1.66
53
120
64
207
3.80
17.26
7.5
4.4
1.06
0.98
mmol/l
1.01
59
193
53
162
3.87
15.39
15.2
6.3
0.68
1.00
mmol/l
0.14
46
129
33
70
5.27
15.19
7.4
2.9
23.97
24.21
mmol/l
0.14
33
70
47
149
3.64
12.83
7.3
2.8
2.26
1.76
mmol/l
0.40
40
124
86
395
2.78
12.48
2.7
1.8
2.67
2.97
mg/l
0.53
77
338
175
2185
0.36
11.88
50.5
17.6
39.48
40.71
%
2.21
167
2036
35
99
3.94
11.20
21.3
7.3
93.43
94.13
%
0.30
35
99
51
187
3.16
10.99
1.9
1.7
—
—
—
0
0
34
97
3.89
10.74
21.7
7.4
0.59
0.69
%
0.93
34
97
51
190
3.11
10.69
2.0
1.7
—
—
—
0
0
37
115
3.60
10.33
3.7
2.1
7.92
5.76
ug/l
0.27
37
105
33
97
3.76
9.99
22.0
7.3
1.65
1.49
%
0.33
33
97
62
267
2.75
9.95
2.3
1.8
—
—
—
0
0
126
770
2.26
9.28
30.2
5.9
1.46
1.11
inr
2.17
27
213
151
1947
0.45
8.62
4.6
4.3
4.51
4.66
mmol/l
1.01
134
1798
150
1934
0.45
8.41
4.6
4.3
1.32
1.41
mmol/l
1.61
133
1776
157
1986
0.45
8.20
5.2
4.8
2.58
2.79
mmol/l
1.95
141
1822
142
950
2.12
7.91
12.6
6.8
13.47
11.77
umol/l
0.98
137
896
43
172
2.81
7.84
3.1
2.4
33.58
29.56
u/l
0.38
36
147
42
169
2.78
7.57
14.2
5.2
237.60
244.37
u/l
0.14
42
160
44
182
2.71
7.52
2.2
2.5
0.22
0.22
g/l
0.01
39
174
49
217
2.56
7.30
21.3
5.9
101.63
104.04
mmol/l
1.76
49
217
31
108
3.13
7.19
1.9
1.4
—
—
—
0
0
109
680
2.06
7.12
3.6
2.3
183.87
182.97
ug/l
0.01
102
623
31
109
3.10
7.08
1.6
1.3
—
—
—
0
0
53
253
2.38
6.70
3.6
1.7
2.13
1.54
%
1.70
47
223
17
31
5.80
6.42
1.3
1.3
—
—
—
0
0
17
31
5.80
6.42
1.3
1.3
—
—
—
0
0
88
529
2.02
6.20
3.2
2.9
1.02
0.63
e6/l
0.42
73
383
119
794
1.94
6.20
13.4
4.7
1.18
1.22
mmol/l
5.32
114
723
65
1057
0.48
6.02
3.9
4.7
1.93
2.63
ug/l
0.81
54
951
44
205
2.39
5.84
3.9
3.3
14.84
8.54
umol/l
0.54
37
184
150
1865
0.52
5.79
4.4
3.9
1.59
1.34
mmol/l
2.49
132
1706
22
73
3.20
5.52
8.4
2.2
1.44
1.40
%
0.04
22
73
49
861
0.47
5.51
3.6
4.2
20.28
21.49
%
0.23
18
433
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
37
4.54
5.03
4.9
2.5
0.33
0.30
u/ml
—
9
16
21
72
3.09
5.00
8.6
2.2
0.68
0.68
%
0.02
21
72
16
46
3.64
4.98
1.4
1.4
—
—
—
0
0
15
42
3.73
4.84
6.0
4.3
4.19
3.87
mmol/l
1.77
15
42
102
690
1.80
4.78
3.6
2.9
—
—
—
0
0
17
53
3.37
4.71
5.5
5.0
2.14
1.39
mmol/l
0.61
17
53
153
1846
0.57
4.42
6.2
5.6
42.43
40.08
mmol/mol
1.45
136
1709
121
875
1.73
4.41
14.1
5.5
1.18
1.22
mmol/l
3.91
102
748
63
377
1.89
4.32
7.0
1.7
1.90
1.44
mg/l
0.35
51
301
161
1912
0.57
4.30
5.1
4.4
6.44
6.02
mmol/l
1.85
145
1743
9
13
7.13
4.20
1.3
1.7
213.67
369.54
u/l
—
9
13
86
572
1.76
4.17
3.8
3.6
48.97
31.49
u/l
2.43
79
554
67
414
1.84
4.14
3.8
2.5
—
—
—
0
0
55
332
1.84
3.63
3.1
2.7
1.16
1.27
e6/l
0.08
38
193
160
1876
0.60
3.56
32.0
11.4
80.76
81.47
ml/min/173m2
0.14
145
1519
10
23
4.48
3.34
1.0
1.3
—
—
—
0
0
20
84
2.50
3.32
9.5
7.0
23.28
24.89
mmol/l
0.95
20
79
38
627
0.54
3.16
2.2
2.9
0.53
0.75
ug/l
1.68
28
413
23
106
2.29
3.14
2.0
1.7
—
—
—
0
0
11
30
3.78
3.12
1.7
1.8
—
—
—
0
0
11
30
3.78
3.12
1.9
1.7
—
—
—
0
0
11
32
3.55
2.93
2.2
2.5
4.33
5.02
kpa
1.92
11
32
134
1070
1.53
2.86
12.1
9.4
4.43
4.13
e9/l
0.67
121
944
10
28
3.67
2.81
1.0
1.4
—
—
—
0
0
11
34
3.33
2.76
1.2
1.2
—
—
—
0
0
6
10
6.11
2.71
2.3
1.6
—
—
—
0
0
6
10
6.11
2.71
2.3
1.6
—
—
—
0
0
6
10
6.11
2.71
2.3
1.6
—
—
—
0
0
8
19
4.31
2.70
2.0
1.9
—
—
—
0
0
90
667
1.54
2.66
6.2
2.6
34.34
42.50
ng/l
0.40
76
465
8
20
4.09
2.59
1.0
1.4
—
—
—
0
0
13
50
2.69
2.57
1.5
1.1
—
—
—
0
0
15
63
2.47
2.51
1.6
2.7
—
—
—
0
0
8
22
3.72
2.38
2.0
1.8
—
—
—
0
0
8
22
3.72
2.38
2.0
1.8
—
—
—
0
0
5
8
6.35
2.38
1.0
2.1
104.60
99.63
%
—
5
8
7
17
4.20
2.37
1.3
1.6
—
—
—
0
0
10
34
3.02
2.31
1.2
1.1
282.30
311.25
u/ml
—
10
20
170
1908
0.67
2.26
35.3
12.0
28.55
25.43
mg/l
0.64
158
1466
33
519
0.58
2.23
1.8
1.7
1.73
1.44
mmol/l
0.75
28
433
11
42
2.69
2.17
1.5
1.2
—
—
—
0
0
6
14
4.36
2.16
2.5
1.6
—
—
—
0
0
87
1089
0.69
2.01
3.0
2.7
—
—
—
0
0
46
318
1.55
1.82
3.3
2.9
1.66
1.29
e6/l
0.14
28
181
6
18
3.39
1.75
1.0
1.6
—
—
—
0
0
6
18
3.39
1.75
1.0
1.6
—
—
—
0
0
29
183
1.66
1.66
4.8
3.1
—
—
—
0
0
77
601
1.40
1.65
5.2
3.5
2.33
2.35
mmol/l
0.81
67
532
48
343
1.49
1.63
4.2
3.0
2.46
2.44
mmol/l
0.27
41
307
163
1437
1.37
1.63
14.3
7.6
87.15
80.77
u/l
0.85
157
1348
0
43
0.00
1.53
0.0
1.3
—
—
—
0
0
6
21
2.90
1.51
1.0
1.4
—
—
—
0
0
0
45
0.00
1.51
0.0
1.1
—
—
—
0
0
125
1075
1.32
1.39
12.7
3.8
6.89
6.74
mmol/l
0.32
120
998
6
23
2.65
1.37
3.5
3.1
—
—
—
0
0
5
18
2.81
1.29
3.0
2.1
—
—
—
0
0
100
841
1.31
1.28
3.7
2.6
—
—
—
0
0
5
21
2.41
1.09
1.4
1.3
—
—
—
0
0
58
715
0.76
1.08
4.9
3.2
—
—
—
0
0
9
46
1.99
1.05
1.0
1.5
—
—
—
0
0
43
331
1.36
1.00
2.1
1.7
1218.46
1117.64
nmol/l
0.22
34
242
90
769
1.26
0.98
2.1
1.9
80.85
94.39
pmol/l
2.03
56
398
154
1673
0.80
0.96
4.8
4.0
2.04
2.66
mu/l
0.39
143
1482
11
63
1.78
0.91
1.3
3.0
—
—
—
0
0
23
162
1.46
0.88
2.6
2.3
425.61
372.86
nmol/l
1.00
23
153
13
80
1.66
0.86
3.5
3.7
4.28
4.85
pmol/l
1.04
13
66
16
107
1.53
0.78
3.5
2.3
5.03
5.05
kpa
0.04
16
101
20
273
0.71
0.73
1.9
1.4
—
—
—
0
0
14
204
0.67
0.72
2.6
2.2
7.61
14.26
nmol/l
2.67
14
187
17
238
0.69
0.71
21.8
5.5
—
—
—
0
0
5
26
1.94
0.71
2.4
1.4
103.80
96.32
pmol/l
—
5
26
5
27
1.87
0.69
1.2
1.3
17.60
18.37
ug/l
—
5
27
5
27
1.87
0.69
1.0
1.1
—
—
—
0
0
5
93
0.53
0.68
1.0
1.0
—
—
—
0
0
7
43
1.65
0.67
1.9
1.5
—
—
—
0
0
7
44
1.61
0.65
2.9
2.6
—
—
—
0
0
17
122
1.42
0.62
4.8
2.9
54.17
70.63
ml/min/173m2
—
6
49
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
0
21
0.00
0.60
0.0
1.5
—
—
—
0
0
8
52
1.56
0.60
1.1
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
511.36
—
0
11
0
22
0.00
0.59
0.0
1.0
—
35.91
—
0
11
0
23
0.00
0.58
0.0
1.4
—
—
—
0
0
80
711
1.18
0.57
2.5
2.2
71.63
76.54
nmol/l
0.67
74
632
6
37
1.64
0.56
3.0
2.6
—
—
—
0
0
83
917
0.86
0.51
4.1
3.1
0.00
0.00
estimate
-0.00
15
146
41
481
0.82
0.50
5.4
3.2
0.00
0.01
estimate
0.50
14
151
10
67
1.51
0.50
3.6
1.8
—
—
—
0
0
83
908
0.87
0.44
4.1
3.1
0.00
0.01
estimate
0.50
15
172
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
122
1297
0.89
0.41
4.0
3.3
14.74
14.75
pmol/l
0.02
115
1138
5
34
1.48
0.40
1.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
8
61
1.32
0.40
2.6
1.7
—
—
—
0
0
9
68
1.34
0.38
4.3
2.3
24.36
24.65
mmol/l
—
9
63
83
900
0.88
0.38
5.4
4.4
0.00
0.00
estimate
-0.00
15
158
9
121
0.73
0.36
3.1
2.0
—
—
—
0
0
6
46
1.31
0.33
1.0
1.0
—
0.72
—
0
5
10
131
0.75
0.31
3.0
2.1
—
—
—
0
0
7
54
1.30
0.30
1.0
1.4
—
—
—
0
0
8
62
1.30
0.28
2.1
1.2
—
—
—
0
0
8
62
1.30
0.28
2.1
1.2
—
—
—
0
0
5
42
1.19
0.21
1.6
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
16
137
1.18
0.19
4.2
3.9
1.18
1.23
mmol/l
1.96
16
127
130
1257
1.07
0.18
5.3
3.1
115.12
57.82
u/l
3.95
122
1175
134
1380
0.94
0.17
4.2
3.7
18.10
11.49
mm/h
2.89
124
1260
7
88
0.79
0.15
3.4
3.6
139.07
1971.57
u/ml
—
7
76
16
142
1.14
0.13
1.4
1.4
—
—
—
0
0
10
85
1.18
0.12
2.0
1.3
—
—
—
0
0
41
393
1.05
0.07
1.9
1.7
451.73
30124638.46
pmol/l
0.79
30
322
59
608
0.96
0.07
3.9
3.6
9.91
4.45
mg/mmol
0.86
47
396
27
278
0.97
0.02
1.1
1.2
10.96
14.23
u/ml
—
8
104
36
367
0.98
0.01
1.2
1.2
3.46
1.29
u/ml
—
5
94
28
282
0.99
0.00
1.1
1.2
26.54
36.41
iu/ml
—
10
87
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
131.14
—
0
8
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
46.22
—
0
6
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
1609.43
—
0
7
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
49
1.02
-0.00
1.2
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
1117.17
—
0
6
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
109.20
—
0
5
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
40.21
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMSEC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMSEC | 6.432 [4.18, 9.9] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.206 |
During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 233 females with I9_CARDMSEC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMSEC | 7.233 [5.83, 8.98] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 480 out of 782 males with I9_CARDMSEC died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMSEC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.612% | 1.675% |
| 5 | 3.985% | 8.275% |
| 10 | 9.404% | 18.906% |
| 15 | 17.163% | 33.051% |
| 20 | 27.778% | 49.542% |
Relationships between endpoints
↥Index endpoint: I9_CARDMSEC – Cardiomyopathies, Secondary/extrinsic
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data