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R13

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Heberden's nodes [with arthropathy]

Endpoint Browser PheWeb

M13_HEBERDENS_NODES

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M15.1
  • Cause of death: ICD-10 — M15.1

2 out of 7 registries used, show all original rules.

309

4. Check minimum number of events

None

309

5. Include endpoints

None

309

6. Filter based on genotype QC (FinnGen only)

304

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 304 251 53
Unadjusted period prevalence (%) 0.08 0.09 0.02
Median age at first event (years) 57.26 57.14 57.81

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
309
Matched controls
3090
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M15.1
ICD-10 Finland
Heberden nodes (with arthropathy)
+∞
307.7
309
*
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
5.4
18.3
39
81
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.3
16.0
71
254
M01AX05
ATC
glucosamine; oral
2.7
15.6
122
597
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
3.1
15.4
79
308
P01BA02
ATC
hydroxychloroquine; oral
3.4
14.1
57
192
ZYC01, ,
SPAT
3.7
13.4
47
144
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
6.0
13.1
24
43
M15.2
ICD-10 Finland
Bouchard nodes (with arthropathy)
135.3
12.5
13
*
ZXH06, ,
SPAT
4.3
11.5
31
78
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
3.2
11.3
50
177
ZYC01
NOMESCO Finland
Remote contact by phone
3.9
11.0
34
95
M01AB05
ATC
diclofenac; systemic, rectal
2.5
10.6
239
1779
N03AX16
ATC
[U] pregabalin
2.3
10.5
105
560
M15.8
ICD-10 Finland
Other polyarthrosis
5.6
10.3
20
38
WZC00, ,
SPAT
3.0
9.4
45
166
WW200, ,
SPAT
2.2
9.0
98
535
M25.5
ICD-10 Finland
Pain in joint
2.1
8.8
128
781
M70.6
ICD-10 Finland
Trochanteric bursitis
2.3
8.6
75
372
OAB42, ,
SPAT
2.8
8.5
46
182
M01AC06
ATC
meloxicam; systemic, rectal
2.0
8.5
157
1044
A02BC02
ATC
pantoprazole; systemic
2.3
8.4
239
1856
M15.4
ICD-10 Finland
Erosive (osteo)arthrosis
11.2
8.4
15
14
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.3
7.8
70
352
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
7.4
7.6
17
24
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.8
7.5
38
145
N02AX02
ATC
tramadol; systemic, rectal
1.9
7.4
157
1076
M01AB16
ATC
aceclofenac; oral
4.0
7.2
21
56
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.4
7.0
51
233
UJF32
NOMESCO Finland
Coloscopy
2.0
6.9
101
608
H02AB06
ATC
prednisolone; systemic
1.9
6.8
164
1162
M01AH01
ATC
celecoxib; oral
2.0
6.5
80
452
OAB47, ,
SPAT
3.9
6.5
19
51
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
8.4
6.4
13
16
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.9
6.1
30
112
WZC30, ,
SPAT
3.0
6.1
27
95
M54.5
ICD-10 Finland
Low back pain
1.8
6.1
123
818
M05BA04
ATC
alendronic acid; oral
2.4
6.0
43
194
OAB44, ,
SPAT
2.7
6.0
34
137
L04AX03
ATC
methotrexate; systemic
2.4
6.0
44
201

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
45
90
5.68
22.15
6.3
11.1
—
—
—
0
0
99
479
2.57
12.54
1.2
1.3
7.07
9.90
u/ml
0.31
48
176
115
605
2.43
12.10
5.4
4.2
1.01
1.02
kg/l
0.54
17
79
100
501
2.47
11.64
1.3
1.3
55.77
39.97
iu/ml
0.41
43
158
35
100
3.82
10.95
1.2
1.3
7.09
3.01
u/ml
—
10
9
115
641
2.26
10.29
4.9
3.8
—
—
—
0
0
75
352
2.49
9.88
1.3
1.3
590.00
593.18
titre
0.00
20
88
55
239
2.58
8.43
3.8
3.3
—
—
—
0
0
185
1306
2.04
8.40
6.2
5.5
0.53
0.57
e9/l
1.36
169
1127
184
1312
1.99
7.95
6.3
5.5
0.04
0.04
e9/l
0.32
167
1131
186
1334
1.99
7.87
6.3
5.5
1.80
1.95
e9/l
0.80
172
1180
189
1368
1.98
7.73
5.0
3.9
0.00
0.03
estimate
0.80
24
240
186
1341
1.97
7.67
5.0
3.9
0.00
0.00
estimate
0.50
26
259
187
1355
1.96
7.55
6.3
5.1
0.00
0.00
estimate
-0.00
23
245
116
738
1.92
6.72
5.6
4.2
0.00
0.00
estimate
-0.00
22
242
184
1361
1.87
6.60
6.5
5.7
0.18
0.18
e9/l
0.09
172
1195
169
1240
1.80
6.01
7.0
6.0
—
—
—
0
0
151
1075
1.79
5.91
4.8
3.6
5.57
5.95
ph
—
7
66
196
1539
1.75
5.18
8.3
9.4
3.81
3.89
e9/l
0.21
181
1355
242
2031
1.88
5.00
6.1
4.3
11.38
13.02
mm/h
1.61
234
1859
100
677
1.71
4.39
4.5
6.6
—
—
—
0
0
155
1187
1.61
4.14
2.5
2.3
82.26
80.51
nmol/l
0.37
143
1039
244
2131
1.69
3.48
7.3
7.4
73.84
79.51
u/l
2.09
231
1984
119
895
1.54
3.22
2.6
2.3
54.85
65.74
u/l
0.96
111
818
97
699
1.57
3.17
2.4
2.5
305.30
9785.75
umol/l
4.21
87
591
77
528
1.61
3.10
2.5
2.9
2.44
2.46
mmol/l
0.82
66
469
25
121
2.16
3.02
1.5
2.1
—
—
—
0
0
20
92
2.26
2.73
1.2
1.3
1.16
1.23
g/l
0.51
20
87
134
1064
1.46
2.67
4.1
3.7
50.47
31.68
ng/l
0.25
87
778
33
187
1.86
2.61
1.5
1.3
—
—
—
0
0
82
593
1.52
2.59
1.4
1.2
1.57
1.23
u/ml
0.20
38
158
48
306
1.67
2.56
2.0
2.0
97.51
157.30
ug/g
1.08
36
238
212
1846
1.47
2.54
5.3
4.5
—
—
—
0
0
8
21
3.88
2.48
2.3
1.4
—
—
—
0
0
12
47
2.62
2.30
1.2
1.4
—
—
—
0
0
18
88
2.11
2.16
1.2
1.3
0.20
0.24
g/l
1.40
18
83
36
227
1.66
2.02
3.5
3.1
74.88
77.37
ng/l
0.08
31
196
31
189
1.71
1.96
2.9
2.8
—
—
—
0
0
6
17
3.58
1.84
1.2
1.2
—
—
—
0
0
279
2626
1.64
1.83
16.5
14.0
15.82
21.81
mg/l
4.04
225
2058
107
863
1.37
1.81
3.7
3.6
7.39
7.40
ph
0.35
18
166
147
1246
1.34
1.80
6.2
5.5
57.85
56.85
%
0.50
142
1159
104
836
1.37
1.79
1.9
2.3
—
—
—
0
0
145
1229
1.34
1.76
6.3
5.5
2.74
2.82
%
0.18
138
1138
25
148
1.75
1.76
2.6
3.5
—
—
—
0
0
147
1255
1.33
1.68
6.5
5.7
27.54
28.38
%
0.44
142
1169
144
1235
1.31
1.56
6.7
5.9
8.70
8.51
%
0.33
139
1147
139
1188
1.31
1.54
6.5
5.5
0.73
0.72
%
0.09
134
1097
161
1404
1.31
1.54
5.8
6.0
1.22
1.22
mmol/l
0.09
145
1184
66
505
1.39
1.52
1.4
1.6
2.15
2.46
g/l
0.73
47
295
149
1288
1.30
1.51
6.2
5.2
1.21
1.22
mmol/l
0.45
142
1165
35
237
1.54
1.50
5.3
4.4
0.80
1.03
%
—
5
77
111
923
1.32
1.49
3.6
3.0
—
—
—
0
0
63
806
0.73
1.47
1.5
1.7
1.51
1.34
mmol/l
0.48
46
670
37
257
1.50
1.42
1.4
1.5
—
—
—
0
0
233
2153
1.33
1.38
4.6
4.3
14.95
14.86
pmol/l
0.24
223
1946
46
338
1.42
1.34
1.5
1.3
—
—
—
0
0
73
580
1.34
1.33
1.7
1.7
437.43
10661441.94
pmol/l
0.50
65
469
6
24
2.53
1.31
1.2
1.0
—
—
—
0
0
18
289
0.60
1.30
3.9
4.0
—
—
—
0
0
114
969
1.28
1.27
2.8
3.4
2.35
2.36
mmol/l
0.42
105
846
88
728
1.29
1.20
3.7
3.1
0.19
0.51
e6/l
2.15
65
538
8
38
2.13
1.19
1.8
1.7
—
—
—
0
0
78
636
1.30
1.19
2.9
2.0
3.29
3.21
mg/l
0.12
72
548
134
1170
1.26
1.18
8.7
9.5
0.00
0.00
e9/l
1.26
109
956
31
219
1.46
1.12
1.5
1.4
—
—
—
0
0
265
2521
1.36
1.09
5.4
5.2
2.07
2.41
mu/l
0.27
250
2274
18
274
0.64
1.06
1.3
1.4
—
—
—
0
0
34
251
1.40
0.99
1.5
1.5
—
—
—
0
0
39
295
1.37
0.99
1.7
1.6
—
—
—
0
0
13
78
1.70
0.93
1.5
2.8
—
—
—
0
0
163
1482
1.21
0.91
4.5
6.1
9.71
10.31
umol/l
0.61
156
1394
52
417
1.30
0.90
2.5
3.0
5.02
2.60
e6/l
0.60
31
222
6
30
2.02
0.87
1.0
1.2
—
—
—
0
0
31
232
1.37
0.85
1.3
1.4
—
—
—
0
0
18
121
1.52
0.85
1.3
1.2
—
—
—
0
0
49
395
1.29
0.82
1.4
1.2
—
—
—
0
0
5
100
0.49
0.78
3.0
2.8
—
—
—
0
0
16
107
1.52
0.78
1.1
1.0
—
—
—
0
0
0
28
0.00
0.76
0.0
3.1
—
—
—
0
0
9
54
1.69
0.75
2.0
2.3
—
—
—
0
0
5
24
2.10
0.75
2.4
2.7
—
—
—
0
0
105
931
1.19
0.74
4.1
3.9
136.88
69.56
e6/l
0.28
77
663
77
664
1.21
0.73
1.6
1.5
23.99
21.89
nmol/l
0.51
72
552
48
394
1.26
0.71
1.9
1.9
—
—
—
0
0
97
864
1.18
0.65
3.1
3.0
6.54
6.61
mmol/l
0.06
84
715
20
147
1.39
0.63
2.6
2.5
—
—
—
0
0
99
885
1.17
0.63
3.3
3.7
6.93
7.94
mg/mmol
0.12
64
513
124
1129
1.16
0.63
2.2
2.0
98.66
98.19
pmol/l
0.03
66
514
29
227
1.31
0.62
1.3
2.7
66.90
67.08
g/l
0.04
24
205
19
139
1.39
0.62
1.2
1.3
—
—
—
0
0
5
30
1.68
0.61
1.6
2.4
2.08
3.19
nmol/l
—
5
30
21
157
1.36
0.61
1.4
1.6
1.32
1.34
g/l
0.03
21
141
265
2566
1.23
0.60
5.6
6.0
39.93
39.95
mmol/mol
0.01
252
2365
64
556
1.19
0.57
3.4
2.5
4.60
5.54
e6/l
0.42
57
504
8
55
1.47
0.56
1.0
1.1
—
82.00
—
0
5
15
107
1.42
0.56
9.4
4.6
—
—
—
0
0
106
1163
0.87
0.56
2.0
2.1
—
—
—
0
0
27
213
1.29
0.56
1.3
1.4
—
—
—
0
0
80
712
1.17
0.54
3.7
3.0
—
—
—
0
0
9
133
0.67
0.53
1.1
1.5
—
—
—
0
0
6
100
0.59
0.52
1.3
1.3
—
—
—
0
0
12
85
1.43
0.47
1.3
1.1
—
—
—
0
0
10
68
1.49
0.47
1.1
4.2
—
—
—
0
0
179
1697
1.13
0.47
3.1
3.0
41.36
49.23
u/l
0.82
165
1560
39
330
1.21
0.47
4.0
4.4
1.01
1.06
mmol/l
0.56
34
297
21
165
1.29
0.46
1.1
1.3
—
—
—
0
0
83
913
0.88
0.45
3.1
3.1
—
—
—
0
0
19
148
1.30
0.44
1.8
2.7
0.17
0.15
e6/l
0.07
19
143
8
56
1.44
0.43
1.9
2.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
128
1197
1.12
0.41
4.3
4.0
35.61
35.61
g/l
0.00
118
1112
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
278
2724
1.20
0.40
15.9
13.3
—
—
—
0
0
8
60
1.34
0.40
1.1
1.2
—
—
—
0
0
87
796
1.13
0.40
3.8
3.2
17.24
54.59
e6/l
1.20
68
607
0
18
0.00
0.40
0.0
2.3
—
—
—
0
0
262
2678
0.86
0.39
4.8
4.8
4.68
4.80
mmol/l
1.12
253
2459
24
197
1.24
0.39
1.9
2.6
—
29.12
—
0
8
5
36
1.40
0.38
1.0
1.1
—
—
—
0
0
13
98
1.34
0.38
2.0
1.5
—
—
—
0
0
13
169
0.76
0.38
1.2
1.4
—
—
—
0
0
251
2570
0.88
0.37
4.3
4.2
1.24
1.27
mmol/l
0.40
242
2333
10
134
0.74
0.35
10.8
7.8
—
—
—
0
0
6
43
1.40
0.35
1.0
1.2
—
—
—
0
0
288
2837
1.22
0.34
12.3
10.9
24.76
24.63
u/l
0.05
283
2736
12
91
1.33
0.34
1.6
1.4
247.83
293.66
ug/g
—
6
58
6
45
1.34
0.34
3.2
2.9
3.74
5.22
e9/l
—
6
45
6
45
1.34
0.34
1.2
1.1
—
—
—
0
0
166
1589
1.10
0.32
4.3
4.4
6.52
6.64
mmol/l
0.37
156
1487
261
2661
0.88
0.32
4.7
4.7
1.57
1.58
mmol/l
0.02
253
2429
134
1270
1.10
0.32
2.6
2.4
—
—
—
0
0
79
730
1.11
0.31
4.3
3.5
—
—
—
0
0
24
203
1.20
0.31
1.6
2.0
—
—
—
0
0
62
675
0.90
0.29
4.4
4.1
—
—
—
0
0
36
318
1.15
0.29
8.1
5.9
103.61
103.93
mmol/l
0.18
36
318
10
76
1.33
0.28
4.3
3.3
—
—
—
0
0
90
844
1.09
0.27
2.9
3.1
33.29
126.31
mg/l
0.58
53
502
22
188
1.18
0.26
1.2
1.1
—
—
—
0
0
23
198
1.17
0.25
2.8
2.8
10.49
9.74
g/l
0.40
23
182
9
76
1.19
0.25
2.1
1.8
6279.33
21805.00
e6/l
—
9
55
31
348
0.88
0.24
1.1
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
9.3
—
0.67
—
0
11
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
20
173
1.17
0.21
4.7
4.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
48.67
—
0
12
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
10.5
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
0.85
—
0
8
65
609
1.09
0.20
1.7
1.6
0.88
1.12
mg/l
0.70
55
492
6
48
1.25
0.20
3.2
3.4
61.00
60.77
%
—
6
48
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
57
532
1.09
0.19
2.0
1.7
1330.50
1260.83
nmol/l
0.22
50
389
13
109
1.20
0.19
1.6
1.8
—
—
—
0
0
7
60
1.17
0.18
1.1
1.3
25.10
28.11
iu/l
—
7
49
10
82
1.23
0.17
1.1
1.4
—
—
—
0
0
13
152
0.85
0.17
5.4
3.3
—
7.41
—
0
22
124
1282
0.95
0.16
12.8
12.2
1.12
1.17
inr
0.32
31
373
19
168
1.14
0.16
7.9
7.4
26.82
25.15
mmol/l
1.30
19
160
15
130
1.16
0.16
5.7
2.2
0.84
0.65
%
1.20
15
130
9
78
1.16
0.15
3.7
4.3
—
—
—
0
0
62
654
0.93
0.15
1.2
1.3
—
—
—
0
0
20
223
0.89
0.15
4.4
4.0
—
—
—
0
0
292
2899
1.13
0.14
24.2
21.1
39.49
39.75
%
0.29
279
2721
35
325
1.09
0.14
1.2
1.3
—
—
—
0
0
292
2900
1.13
0.13
24.4
21.1
6.34
6.50
e9/l
0.76
287
2818
292
2901
1.12
0.12
24.5
21.1
4.40
4.42
e12/l
0.42
287
2821
56
534
1.06
0.11
4.0
2.8
523.14
517.38
mosm/kgh2o
0.08
51
456
32
300
1.07
0.10
6.4
6.7
2.33
1.61
mmol/l
0.59
27
246
197
1943
1.04
0.09
3.8
3.9
—
—
—
0
0
17
155
1.10
0.09
1.1
1.2
—
—
—
0
0
7
65
1.08
0.08
1.9
1.2
3.84
3.93
mmol/l
—
7
59
267
2652
1.05
0.07
4.7
4.9
5.90
5.94
mmol/l
0.26
261
2399
12
108
1.12
0.07
4.2
4.4
1.36
1.48
%
0.30
12
100
21
196
1.08
0.07
9.2
7.3
—
—
—
0
0
48
498
0.96
0.07
3.8
3.8
96.42
164.32
ng/l
0.38
36
390
18
188
0.95
0.02
1.1
1.2
204.16
144.82
iu/ml
—
5
74
87
860
1.02
0.02
4.3
3.8
—
—
—
0
0
22
228
0.96
0.02
4.1
3.0
0.66
0.75
ug/l
0.31
14
150
24
232
1.04
0.02
1.2
1.5
—
—
—
0
0
25
244
1.03
0.00
7.4
7.2
123.04
119.20
g/l
0.40
25
238
274
2734
1.02
0.00
5.6
5.4
2.71
2.79
mmol/l
0.92
265
2490
26
261
1.00
0.00
7.2
6.9
93.27
95.98
%
0.53
26
252
11
107
1.03
0.00
4.2
4.5
0.90
0.91
%
0.02
11
100
11
114
0.96
0.00
4.5
3.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
14.62
—
0
5
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
5
57
0.88
-0.00
1.2
1.7
—
—
—
0
0
5
57
0.88
-0.00
1.4
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
-0.00
1.7
1.2
485.14
502.49
mg/l
—
7
68
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
7
74
0.94
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
16.4
—
694.29
—
0
7
0
6
0.00
-0.00
0.0
5.7
—
26.18
—
0
6
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
20.9
—
1328.86
—
0
7
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
73
0.96
-0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: M13_HEBERDENS_NODES – Heberden's nodes [with arthropathy]

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).