No definition available.
Congenital malformations of gallbladder, bile ducts and liver
Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
326 |
4. Check minimum number of eventsNone |
326 |
5. Include endpointsNone |
326 |
6. Filter based on genotype QC (FinnGen only) |
326 |
Control definitions (FinnGen only)
- Control exclude
- Q17_OTHER_CONGEN_MALFO_DIGES_SYSTEM1
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q3[8-9]|Q4[0-5]
- Name in latin
- Malformationes congenitae vesicae biliaris, ductuum biliarium et hepatis
Similar endpoints
↥List of similar endpoints to
Congenital malformations of gallbladder, bile ducts and liver
based on the number of shared cases.
Similar with more cases:
- Other congenital malformations of the digestive system
- Congenital malformations, deformations and chromosomal abnormalities
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1971 | 1312 | 646 |
| Only index persons | 1660 | 1143 | 517 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 55.99 | 55.62 | 56.39 |
| Only index persons | 56.48 | 55.83 | 57.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 326 | 226 | 100 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.04 |
| Median age at first event (years) | 53.53 | 51.33 | 58.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 279
- Matched controls
- 2790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q44.6
ICD-10 Finland
Cystic disease of liver
+∞
234.9
191
*
K76.80
ICD-10 Finland
Hepatic cyst
498.6
76.8
73
*
Q61.3
ICD-10 Finland
Polycystic kidney, unspecified
516.0
45.6
44
*
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
109.7
43.3
46
5
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
66.7
39.7
45
8
127
Kela drug reimbursment
Transplant complication
31.6
39.3
52
20
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.5
36.0
110
252
Z94.4
ICD-10 Finland
Liver transplant status
90.0
35.9
39
5
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
9.7
34.1
74
100
Q44.21
ICD-10 Finland
Atresia of extrahepatic bile ducts
+∞
34.1
32
*
JJA31
NOMESCO Finland
Laparoscopic marsupialisation of cyst of liver
+∞
31.9
30
*
K83.0
ICD-10 Finland
Cholangitis
29.0
29.8
40
16
JKD50
NOMESCO Finland
Hepatoportoenterostomy
+∞
29.7
28
*
Q44.29
ICD-10 Finland
Atresia of bile ducts
+∞
29.7
28
*
A11CC03
ATC
alfacalcidol; systemic
19.9
29.1
44
26
Z94.0
ICD-10 Finland
Kidney transplant status
35.3
29.0
37
12
A05AA02
ATC
ursodeoxycholic acid; oral
23.1
27.9
40
20
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
18.8
27.3
42
26
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
24.2
26.9
38
18
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
35.0
26.6
34
11
JJC00
NOMESCO Finland
Allogenic transplantation of liver
285.6
26.2
26
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.0
24.5
132
509
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
20.5
24.2
36
20
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
17.6
23.6
37
24
JJ5KT
NOMESCO Finland
Sclerotherapy of liver cyst
249.7
23.0
23
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
22.4
22.3
32
16
L04AD01
ATC
ciclosporin; systemic
17.2
22.2
35
23
TBW99
NOMESCO Finland
Other minor procedure in endocrine surgery
18.5
21.6
33
20
L04AA06
ATC
mycophenolic acid; systemic
17.9
20.7
32
20
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
113.1
19.8
21
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
17.8
18.8
29
18
TK800
NOMESCO Finland
Hemodialysis
18.2
18.3
28
17
JCA32
NOMESCO Finland
Endoscopic injection in oesophagus
+∞
17.9
17
*
Q44.4
ICD-10 Finland
Choledochal cyst
+∞
17.9
17
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.7
17.9
54
112
A12AA04
ATC
calcium carbonate; oral
26.1
17.6
24
10
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.1
17.3
139
682
Q44.20
ICD-10 Finland
Atresia of intrahepatic bile ducts
+∞
16.8
16
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.0
16.6
57
137
L04AX01
ATC
azathioprine; systemic
8.0
16.2
37
52
WX408
NOMESCO Finland
General anesthesy, balanced
3.1
15.8
116
527
JJ5AT
NOMESCO Finland
NA
169.1
15.6
16
*
JAH00
NOMESCO Finland
Laparotomy
11.4
15.6
29
28
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
12.3
15.1
27
24
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
12.3
15.1
27
24
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
19.8
14.9
22
12
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
26.8
14.9
20
8
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
7.4
14.6
35
53
WX402
NOMESCO Finland
General anaesthesia
3.3
14.6
86
331
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
29.0
14.5
19
7
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
56.3
14.0
16
*
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
19.5
13.6
20
11
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
42.3
13.3
16
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
73.3
12.7
14
*
H02AB09
ATC
hydrocortisone; systemic
7.8
12.7
29
41
Q44.1
ICD-10 Finland
Other congenital malformations of gallbladder
+∞
12.6
12
*
Q44.3
ICD-10 Finland
Congenital stenosis and stricture of bile ducts
+∞
12.6
12
*
H02AB04
ATC
methylprednisolone; systemic
3.4
12.4
66
231
RD210
NOMESCO Finland
NA
7.4
12.3
29
43
R50.9
ICD-10 Finland
Fever, unspecified
3.1
12.2
75
294
JN3AD
NOMESCO Finland
Abdominal CT examination
5.0
12.1
39
87
WX302
NOMESCO Finland
Thoracal epidural anesthesy
6.2
11.9
32
57
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
11.7
139
799
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
11.5
80
337
V03AE02
ATC
sevelamer; oral
+∞
11.5
11
*
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
13.5
11.3
19
15
Z49.1
ICD-10 Finland
Extracorporeal dialysis
21.1
11.3
16
8
B03XA02
ATC
darbepoetin alfa; parenteral
12.6
11.0
19
16
TPH07
NOMESCO Finland
Cathetrisation of artery
3.6
11.0
51
161
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
6.2
10.9
29
51
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.2
10.7
33
70
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.3
10.7
40
104
Q44.78
ICD-10 Finland
Other congenital malformations of the liver
+∞
10.5
10
*
K00.81
ICD-10 Finland
Color changes in the teeth caused by biliary anomalies
+∞
10.5
10
*
Q44.0
ICD-10 Finland
Agenesis, aplasia and hypoplasia of gallbladder
+∞
10.5
10
*
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
8.0
10.4
23
31
L04AA01
ATC
[U] ciclosporin; systemic
19.7
10.4
15
8
R4110
NOMESCO Finland
Physiotherapy
2.5
10.3
100
509
205
Kela drug reimbursment
Chronic hypertension
2.6
10.1
87
413
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
21.0
9.9
14
7
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
5.9
9.8
27
50
7531A
ICD-9 Finland
Congenital anomalies of urinary system, Cystic kidney disease
+∞
9.4
9
*
Q44.75
ICD-10 Finland
Focal nodular hypoplasia of the liver
+∞
9.4
9
*
BE00A
NOMESCO Finland
NA
+∞
9.4
9
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.5
9.4
45
145
XF602
NOMESCO Finland
Bloodpressure monitoring
10.6
9.2
17
17
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
38.0
9.1
11
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
38.0
9.1
11
*
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
5.9
8.8
24
44
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
14.7
8.8
14
10
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
5.3
8.8
26
53
JJC10
NOMESCO Finland
Allogenic partial transplantation of liver
51.6
8.7
10
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
7.8
8.6
19
26
N18.8
ICD-10 Finland
Other chronic renal failure
7.8
8.6
19
26
5AB14
NOMESCO Finland
NA
28.5
8.5
11
*
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
20.8
8.5
12
6
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
8.5
67
300
602
Kela drug reimbursment
Children's severe malnutrition
8.3
8.5
18
23
JJ1AT
NOMESCO Finland
Puncture of lesion of liver with ultrasound guidance
92.7
8.5
9
*
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
11.2
8.4
15
14
JK3AN
NOMESCO Finland
Biliary tract isotope imaging
+∞
8.4
8
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
8.2
84
428
J01MA02
ATC
ciprofloxacin; systemic
2.2
8.1
109
637
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
7.9
58
249
D13.4
ICD-10 Finland
Benign neoplasm: Liver
46.3
7.8
9
*
C08CA01
ATC
amlodipine; oral
2.2
7.7
97
545
K83.1
ICD-10 Finland
Obstruction of bile duct
12.3
7.7
13
11
A41.8
ICD-10 Finland
Other specified sepsis
12.3
7.7
13
11
N02AX02
ATC
tramadol; systemic, rectal
2.1
7.5
118
729
Q61.0
ICD-10 Finland
Congenital single renal cyst
82.2
7.5
8
*
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
82.2
7.5
8
*
137
Kela drug reimbursment
Uraemia requiring dialysis
13.9
7.5
12
9
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
5.7
7.4
20
37
R18
ICD-10 Finland
Ascites
9.8
7.4
14
15
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
9.8
7.4
14
15
7516D
ICD-9 Finland
Other congenital anomalies of digestive system, Anomalies of gallbladder, bile ducts and liver[HEPAR POLYCYSTICUM]
+∞
7.3
7
*
JJA20
NOMESCO Finland
Open biopsy of liver
30.9
7.2
9
*
C03CA01
ATC
furosemide; systemic
2.2
7.1
81
433
ZX120
NOMESCO Finland
Intravenous
3.0
6.8
39
143
N18.0
ICD-10 Finland
End-stage renal disease
17.2
6.8
10
6
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
41.1
6.8
8
*
D97
ICPC
Liver disease NOS
41.1
6.8
8
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
23.2
6.7
9
*
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
6.6
145
1001
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.4
6.5
58
276
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.0
6.5
37
136
Q61.1
ICD-10 Finland
Polycystic kidney, autosomal recessive
71.4
6.5
7
*
Q61.99
ICD-10 Finland
Cystic kidney disease, unspecified
71.4
6.5
7
*
Z94.9
ICD-10 Finland
Transplanted organ and tissue status, unspecified
71.4
6.5
7
*
J01XX08
ATC
linezolid; systemic
71.4
6.5
7
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.3
6.3
30
97
KA1AE
NOMESCO Finland
Kidney ultrasound examination
7.3
6.3
14
20
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
7.3
6.3
14
20
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
6.3
63
317
C08CA02
ATC
felodipine; oral
3.1
6.3
35
125
Q44.5
ICD-10 Finland
Other congenital malformations of bile ducts
+∞
6.3
6
*
K83.5
ICD-10 Finland
Biliary cyst
+∞
6.3
6
*
JJA30
NOMESCO Finland
Marsupialisation of cyst of liver
+∞
6.3
6
*
D23
ICPC
Hepatomegaly
+∞
6.3
6
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
27.3
6.3
8
*
JN3DG
NOMESCO Finland
Very extensive MRI examination with high intensity magnet
12.9
6.1
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
160
330
8.56
83.46
23.7
3.3
8.47
7.15
umol/l
0.45
154
284
60
31
23.50
79.12
13.6
2.9
94.10
98.23
%
0.33
60
31
72
60
15.12
74.53
12.5
8.4
414.23
175.56
iu/ml
—
22
9
78
104
9.54
57.81
2.8
3.2
217.76
1633.01
u/ml
0.57
71
94
58
52
13.35
56.90
12.2
5.7
476.13
549.56
u/ml
—
8
9
43
22
22.36
56.42
9.0
2.3
21.09
28.41
umol/l
2.33
43
22
49
37
15.41
53.10
17.1
1.9
37.02
11.66
umol/l
1.76
49
26
253
1114
6.68
52.36
18.2
5.3
35.67
35.99
g/l
0.44
246
1050
86
146
7.64
51.52
17.7
13.3
1.51
1.20
mg/l
2.50
86
140
42
27
17.71
49.46
2.7
1.4
—
—
—
0
0
275
1366
7.48
47.63
24.7
6.6
13.04
14.18
umol/l
0.45
270
1294
59
76
9.26
44.47
2.4
1.9
256.12
205.56
u/ml
0.40
51
32
59
77
9.13
43.99
2.3
1.9
—
—
—
0
0
59
79
8.90
43.06
2.8
1.7
—
—
—
0
0
57
77
8.76
41.24
2.9
1.8
124.00
87.87
u/ml
—
8
10
123
368
4.76
38.81
6.8
2.5
19.80
21.86
%
1.07
112
322
28
13
23.47
37.85
6.1
3.8
—
—
—
0
0
34
32
11.75
31.85
2.1
1.7
—
—
—
0
0
180
800
3.79
31.33
5.2
2.4
61.52
54.99
u/l
1.35
166
739
132
509
3.68
27.91
5.4
3.1
0.50
0.95
e6/l
2.59
100
288
153
659
3.49
27.04
4.7
2.5
—
—
—
0
0
268
1643
4.55
27.02
19.5
3.3
99.03
43.28
u/l
6.28
257
1536
300
2004
7.23
27.00
24.5
7.1
124.62
90.29
u/l
5.95
294
1878
232
1310
3.67
26.06
26.6
7.8
1.21
1.22
mmol/l
1.17
224
1201
88
270
4.09
25.75
3.0
4.2
3.91
25.16
ug/l
0.76
63
225
81
240
4.16
24.80
5.8
2.2
45.65
28.92
u/l
1.68
72
199
239
1401
3.65
24.72
27.5
8.0
1.21
1.22
mmol/l
2.54
222
1214
120
482
3.36
23.11
5.5
3.3
1.65
2.51
e6/l
0.73
90
267
140
621
3.20
22.77
6.7
3.2
333.26
5873.30
umol/l
2.41
130
539
23
20
12.30
22.47
4.2
1.6
0.87
1.05
g/l
0.87
23
20
189
1006
3.09
22.13
8.6
3.5
—
—
—
0
0
89
304
3.65
22.01
14.6
7.5
104.83
103.85
mmol/l
0.94
89
297
212
1209
3.15
21.85
6.5
3.9
—
—
—
0
0
70
210
3.97
20.83
3.3
2.9
48.96
68.87
ml/min/173m2
2.29
26
86
36
62
6.40
20.57
1.5
1.1
—
—
—
0
0
91
333
3.40
20.04
27.2
10.3
24.24
24.87
mmol/l
1.37
91
333
32
50
6.99
20.03
12.7
11.9
78.31
64.57
%
3.03
32
50
159
809
2.88
19.55
8.3
3.4
0.10
0.41
e6/l
3.65
137
594
166
871
2.85
19.15
8.2
3.6
20.45
115.36
e6/l
0.67
145
658
198
1141
2.87
19.04
6.7
2.6
80.56
77.03
nmol/l
1.11
191
1021
28
43
7.03
17.77
1.2
1.1
—
—
—
0
0
152
797
2.70
17.06
5.0
3.7
6.21
7.26
mmol/l
2.41
145
677
57
173
3.78
16.49
1.8
1.5
—
—
—
0
0
18
21
9.01
14.26
1.4
1.2
—
—
—
0
0
93
412
2.76
14.14
2.5
1.8
—
—
—
0
0
43
119
4.01
14.10
14.0
10.8
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
32
70
4.96
14.09
11.6
13.3
0.31
0.34
u/ml
0.26
17
41
74
296
2.94
13.57
2.5
1.7
—
—
—
0
0
238
1673
2.57
12.95
19.6
10.0
3.97
3.94
e9/l
0.06
218
1431
73
299
2.86
12.76
2.6
1.8
—
—
—
0
0
66
256
2.98
12.74
12.5
7.8
-0.12
1.04
mmol/l
1.68
56
211
185
1176
2.33
12.46
5.9
2.9
116.17
101.00
ug/l
0.66
179
1086
131
720
2.37
12.40
2.0
1.7
1.10
1.36
mmol/l
5.05
125
611
17
8
22.32
12.13
1.1
1.1
—
—
—
0
0
123
666
2.36
11.96
3.7
2.5
2.86
3.13
mg/l
0.74
104
575
42
129
3.59
11.83
13.2
6.6
1.36
1.22
%
0.33
42
129
15
5
31.32
11.74
1.0
1.2
—
—
—
0
0
198
1326
2.26
11.37
6.7
3.7
0.00
0.00
estimate
0.00
37
242
203
1377
2.26
11.25
18.0
6.8
2.96
2.92
%
0.10
193
1289
199
1347
2.23
10.97
6.7
3.7
0.00
0.00
estimate
0.00
39
235
110
587
2.32
10.90
8.1
2.6
1.79
1.39
mg/l
0.44
88
460
197
1334
2.20
10.77
9.2
5.1
0.00
0.00
estimate
0.00
38
240
63
261
2.75
10.67
2.8
1.6
1.61
1.51
%
0.32
58
228
203
1398
2.20
10.55
17.8
6.7
57.35
54.62
%
2.19
194
1321
41
134
3.36
10.47
2.1
1.6
—
—
—
0
0
204
1423
2.16
10.06
18.1
6.9
28.18
30.45
%
1.76
195
1339
13
7
19.27
9.00
4.2
6.4
—
—
—
0
0
37
126
3.18
8.83
15.6
10.5
23.54
24.45
mmol/l
1.02
37
119
57
247
2.58
8.76
3.9
3.5
—
—
—
0
0
26
72
3.84
8.47
2.5
1.6
—
—
—
0
0
28
82
3.64
8.43
9.4
5.5
22.15
24.40
mmol/l
2.85
28
70
255
2009
2.24
8.34
9.0
4.3
14.34
11.65
mm/h
2.00
247
1860
26
74
3.73
8.15
1.6
1.3
—
—
—
0
0
286
2380
2.64
8.02
49.6
16.9
14.01
13.63
%
3.32
280
2354
294
2508
2.75
7.30
7.0
4.9
2.53
2.78
mmol/l
6.51
279
2306
13
23
5.85
7.12
2.4
10.6
40.90
544.33
g/mol
0.63
13
18
290
2467
2.59
7.07
6.8
4.4
4.40
4.70
mmol/l
6.28
278
2283
64
321
2.24
7.05
23.0
7.8
0.96
1.37
mmol/l
0.81
46
235
310
2736
3.71
6.92
42.5
13.2
20.63
22.59
mg/l
0.67
278
2081
115
723
1.91
6.84
5.7
3.9
10.72
9.80
mg/mmol
0.08
89
436
16
39
4.26
6.16
1.5
1.2
—
—
—
0
0
14
31
4.67
6.04
1.1
1.2
—
—
—
0
0
14
31
4.67
6.04
1.1
1.2
—
—
—
0
0
285
2455
2.28
5.90
6.5
4.4
1.47
1.51
mmol/l
0.70
270
2256
14
32
4.53
5.82
1.1
1.2
—
—
—
0
0
14
32
4.53
5.82
1.1
1.2
—
—
—
0
0
14
32
4.53
5.82
1.1
1.2
—
—
—
0
0
129
882
1.77
5.64
5.3
3.3
2.36
2.36
mmol/l
0.03
116
779
80
481
1.88
5.29
4.0
3.8
505.54
349.83
ng/l
0.21
68
360
313
2850
3.46
5.16
39.3
15.1
93.76
69.96
umol/l
5.23
313
2850
135
962
1.69
4.93
2.2
2.0
93.71
95.81
pmol/l
0.21
71
461
273
2360
1.96
4.88
6.0
4.0
1.15
1.26
mmol/l
2.09
256
2164
17
53
3.33
4.68
12.8
2.8
4.83
5.02
kpa
0.53
17
53
22
81
2.84
4.61
2.3
2.1
—
—
—
0
0
286
2532
2.06
4.48
48.0
15.0
37.65
39.35
%
4.74
232
1956
19
70
2.82
3.99
1.9
1.3
—
—
—
0
0
19
70
2.82
3.99
1.9
1.3
—
—
—
0
0
8
11
7.42
3.88
1.1
1.5
—
—
—
0
0
31
148
2.21
3.83
1.7
1.4
—
—
—
0
0
14
44
3.28
3.82
4.9
2.8
3.46
4.74
e9/l
1.05
14
44
88
596
1.65
3.74
1.8
1.5
19.73
22.10
nmol/l
1.00
79
493
14
45
3.21
3.69
5.7
3.1
56.50
57.40
%
0.08
14
45
262
2298
1.71
3.66
29.1
12.2
73.14
81.69
ml/min/173m2
4.38
218
1845
17
63
2.79
3.55
1.1
1.2
—
—
—
0
0
6
6
10.15
3.51
5.5
6.3
—
—
—
0
0
7
10
7.13
3.38
1.1
1.0
1841.00
1351.30
miu/ml
—
7
10
217
1835
1.55
3.36
3.4
3.2
—
—
—
0
0
263
2328
1.67
3.33
8.3
5.6
38.05
39.58
mmol/mol
2.04
254
2171
99
708
1.57
3.33
7.8
3.9
0.00
0.00
estimate
0.00
37
240
20
85
2.44
3.22
1.7
2.2
119.26
295.44
ug/l
1.45
20
79
64
415
1.67
3.18
1.9
1.7
1107.10
1246.65
nmol/l
0.72
49
303
21
92
2.37
3.17
1.6
1.3
240.57
308.02
ug/g
0.70
14
54
130
1001
1.50
3.07
6.8
3.7
—
—
—
0
0
273
2457
1.68
3.04
5.7
4.4
5.77
5.88
mmol/l
0.54
257
2254
5
5
10.13
2.99
3.4
1.0
—
—
—
0
0
82
583
1.54
2.78
6.6
3.8
1.02
1.02
kg/l
—
10
92
16
67
2.46
2.67
2.2
1.4
0.00
0.05
iu/ml
—
5
13
15
61
2.53
2.66
2.7
1.6
—
—
—
0
0
12
44
2.79
2.57
2.1
1.5
—
—
—
0
0
11
39
2.88
2.50
1.9
3.0
—
—
—
0
0
62
425
1.57
2.46
1.5
1.4
—
—
—
0
0
317
3044
2.50
2.41
56.6
19.9
4.35
4.48
e12/l
5.25
312
2951
317
3042
2.52
2.41
56.6
19.9
240.93
258.51
e9/l
3.91
311
2957
17
78
2.24
2.35
1.1
1.2
—
3.18
—
0
12
5
9
5.62
2.22
1.2
1.1
—
—
—
0
0
98
755
1.43
2.19
2.1
2.1
143.06
197.85
u/l
0.83
90
710
17
82
2.13
2.11
1.1
1.2
—
2.27
—
0
6
7
20
3.55
2.06
1.3
3.2
—
—
—
0
0
12
50
2.45
2.05
2.3
1.5
—
—
—
0
0
6
15
4.05
2.05
2.0
3.9
225.92
135.20
ug/l
—
6
15
19
99
1.98
1.94
1.2
1.1
—
—
—
0
0
19
100
1.96
1.90
1.2
1.1
—
—
—
0
0
15
74
2.08
1.78
2.6
1.6
—
—
—
0
0
6
18
3.38
1.75
2.3
1.3
—
—
—
0
0
18
96
1.93
1.74
1.6
1.8
—
—
—
0
0
7
24
2.96
1.73
1.3
1.1
—
—
—
0
0
7
25
2.84
1.66
1.3
1.1
—
—
—
0
0
63
471
1.42
1.64
3.7
2.7
2.48
2.45
mmol/l
0.98
56
416
17
91
1.92
1.64
3.8
1.7
—
—
—
0
0
11
52
2.15
1.46
2.4
1.8
—
—
—
0
0
11
53
2.11
1.40
1.4
1.3
—
—
—
0
0
5
17
2.97
1.36
1.8
2.6
950.80
751.53
u/ml
—
5
17
5
17
2.97
1.36
2.0
1.5
0.80
4.14
u/field
—
5
7
0
37
0.00
1.35
0.0
1.5
—
—
—
0
0
16
91
1.80
1.31
5.3
1.7
—
—
—
0
0
16
91
1.80
1.31
1.6
1.7
—
—
—
0
0
6
24
2.53
1.31
1.3
2.7
4.62
3.42
nmol/l
—
6
24
5
18
2.80
1.29
5.2
2.7
910.00
598.11
ml
—
5
9
6
25
2.43
1.25
4.8
3.8
—
—
—
0
0
9
45
2.03
1.24
1.1
1.1
—
—
—
0
0
16
93
1.76
1.23
1.3
1.6
—
—
—
0
0
10
50
2.03
1.17
1.8
1.5
—
—
—
0
0
40
294
1.41
1.17
15.0
6.8
—
—
—
0
0
15
88
1.74
1.13
1.9
1.4
—
—
—
0
0
8
40
2.02
1.13
1.0
1.1
—
—
—
0
0
16
96
1.70
1.12
1.8
2.2
—
—
—
0
0
21
136
1.58
1.11
2.4
3.1
0.12
0.18
e6/l
0.28
21
131
7
32
2.21
1.08
1.0
1.3
—
—
—
0
0
22
321
0.66
1.06
6.0
4.4
36.94
32.19
%
1.71
17
205
5
23
2.19
0.98
5.6
5.4
4.07
1.72
ug/l
—
5
23
5
23
2.19
0.98
2.0
2.8
—
—
—
0
0
5
23
2.19
0.98
2.0
2.8
—
—
—
0
0
0
32
0.00
0.95
0.0
1.3
—
—
—
0
0
0
32
0.00
0.95
0.0
1.3
—
—
—
0
0
0
32
0.00
0.95
0.0
1.3
—
—
—
0
0
7
37
1.91
0.94
4.7
1.5
—
—
—
0
0
10
55
1.84
0.93
1.5
1.3
—
—
—
0
0
36
467
0.74
0.91
1.3
1.3
9.96
38.01
iu/ml
—
10
145
6
30
2.02
0.87
1.2
1.4
—
—
—
0
0
102
891
1.21
0.84
3.1
3.7
77.96
27.28
ng/l
0.40
73
607
28
210
1.36
0.77
1.2
1.3
126.13
142.33
iu/ml
—
9
82
11
67
1.66
0.76
1.5
1.5
—
—
—
0
0
12
75
1.62
0.76
1.4
1.3
63.71
294.56
miu/ml
—
7
33
17
116
1.49
0.76
1.4
1.7
—
—
—
0
0
83
719
1.21
0.74
2.7
3.8
1835.11
1131.96
ng/l
0.59
74
615
7
43
1.64
0.67
4.7
1.5
—
—
—
0
0
5
29
1.74
0.64
2.2
1.4
—
—
—
0
0
5
29
1.74
0.64
2.2
1.4
—
—
—
0
0
5
29
1.74
0.64
2.2
1.4
—
—
—
0
0
48
401
1.23
0.62
4.2
4.3
26.24
21.18
%
1.27
23
199
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
8
53
1.52
0.59
1.5
1.3
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
81.70
—
0
23
21
161
1.33
0.53
1.4
1.3
—
—
—
0
0
13
93
1.41
0.49
1.7
1.4
—
—
—
0
0
56
496
1.16
0.41
1.6
1.7
547.32
458.77
pmol/l
1.01
50
414
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
57
507
1.15
0.39
4.1
4.9
1.79
2.73
ug/l
0.77
52
455
5
78
0.64
0.36
1.0
1.4
—
—
—
0
0
14
108
1.31
0.36
1.6
1.6
—
—
—
0
0
6
87
0.68
0.33
1.2
1.5
267.83
301.90
mu/l
—
6
80
7
55
1.28
0.30
4.9
1.5
—
—
—
0
0
8
62
1.30
0.28
1.7
1.3
—
—
—
0
0
41
456
0.88
0.27
1.3
1.3
1.46
9.98
u/ml
2.66
17
168
5
73
0.68
0.26
1.0
1.0
3.12
3.44
kpa
—
5
56
5
74
0.67
0.26
1.0
1.0
7.24
7.45
kpa
—
5
57
9
73
1.24
0.25
1.1
2.5
3.40
3.78
mmol/l
—
9
68
6
84
0.71
0.24
1.7
1.7
—
—
—
0
0
5
38
1.32
0.23
1.6
1.4
0.48
0.56
nmol/l
—
5
33
5
41
1.22
0.22
3.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
253
2489
1.07
0.18
4.6
4.7
1.93
2.42
mu/l
0.50
239
2280
21
237
0.88
0.18
2.0
1.9
—
—
—
0
0
21
187
1.13
0.16
1.0
1.1
—
—
—
0
0
8
73
1.10
0.16
2.5
2.4
—
—
—
0
0
9
106
0.84
0.13
1.1
1.1
—
—
—
0
0
24
262
0.91
0.13
1.9
2.0
—
—
—
0
0
66
632
1.06
0.12
1.8
1.8
—
—
—
0
0
215
2121
1.04
0.10
4.0
4.0
14.82
14.69
pmol/l
0.34
206
1941
74
766
0.96
0.10
1.4
1.5
2.64
2.77
u/ml
0.03
13
175
19
207
0.91
0.10
1.4
1.7
—
—
—
0
0
15
138
1.09
0.06
1.9
1.6
—
—
—
0
0
10
96
1.04
0.00
1.1
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
49
1.02
0.00
1.0
1.1
—
230.75
—
0
12
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
30
300
1.00
0.00
3.2
3.0
0.69
0.78
ug/l
0.25
23
203
8
86
0.93
0.00
1.3
1.2
—
14.76
—
0
16
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER | 1.328 [1.1, 1.6] | 0.003 |
| Birth year | 1.002 [0.99, 1.01] | 0.663 |
During the follow-up period (1.1.1998 — 31.12.2019), 200 out of 1032 females with Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER | 1.368 [1.01, 1.86] | 0.044 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 130 out of 506 males with Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.181% | 0.232% |
| 5 | 1.032% | 1.42% |
| 10 | 2.439% | 3.794% |
| 15 | 4.731% | 7.375% |
| 20 | 8.411% | 12.237% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER – Congenital malformations of gallbladder, bile ducts and liver
GWS hits: 17
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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