No definition available.
Congenital malformations of gallbladder, bile ducts and liver
Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
348 |
4. Check minimum number of eventsNone |
348 |
5. Include endpointsNone |
348 |
6. Filter based on genotype QC (FinnGen only) |
336 |
Control definitions (FinnGen only)
- Control exclude
- Q17_OTHER_CONGEN_MALFO_DIGES_SYSTEM1
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q3[8-9]|Q4[0-5]
- Name in latin
- Malformationes congenitae vesicae biliaris, ductuum biliarium et hepatis
Similar endpoints
↥List of similar endpoints to
Congenital malformations of gallbladder, bile ducts and liver
based on the number of shared cases.
Similar with more cases:
- Other congenital malformations of the digestive system
- Other congenital malformations of the digestive system
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1971 | 1312 | 646 |
| Only index persons | 1660 | 1143 | 517 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 55.99 | 55.62 | 56.39 |
| Only index persons | 56.48 | 55.83 | 57.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 336 | 231 | 105 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.05 |
| Median age at first event (years) | 54.66 | 52.70 | 58.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 348
- Matched controls
- 3480
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q44.6
ICD-10 Finland
Cystic disease of liver
+∞
292.7
238
*
127
Kela drug reimbursment
Transplant complication
35.4
108.6
71
25
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
63.7
96.3
54
10
K76.80
ICD-10 Finland
Hepatic cyst
188.4
95.7
96
7
Z94.0
ICD-10 Finland
Kidney transplant status
49.6
86.4
51
12
L04AD02
ATC
tacrolimus; systemic
38.8
79.5
50
15
K83.0
ICD-10 Finland
Cholangitis
41.6
76.3
47
13
A11CC03
ATC
alfacalcidol; systemic
22.1
72.4
56
30
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.3
71.0
144
306
L04AA06
ATC
mycophenolic acid; systemic
21.5
64.2
50
27
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
8.4
64.1
100
159
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
20.2
61.3
49
28
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
30.9
61.0
41
15
A05AA02
ATC
ursodeoxycholic acid; oral
21.9
59.9
46
24
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
180.5
59.0
60
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
20.0
58.6
47
27
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
20.0
58.6
47
27
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
22.6
55.6
42
21
TK800
NOMESCO Finland
Hemodialysis
21.6
54.5
42
22
Q61.3
ICD-10 Finland
Polycystic kidney, unspecified
133.0
53.6
56
5
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.7
49.1
79
128
JN3AD
NOMESCO Finland
Abdominal CT examination
6.5
47.3
93
185
Z94.4
ICD-10 Finland
Liver transplant status
116.4
47.2
50
5
Q44.21
ICD-10 Finland
Atresia of extrahepatic bile ducts
+∞
46.9
44
*
L04AD01
ATC
ciclosporin; systemic
14.8
45.0
42
32
TBW99
NOMESCO Finland
Other minor procedure in endocrine surgery
18.4
42.4
35
21
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.2
38.0
169
643
JJA31
NOMESCO Finland
Laparoscopic marsupialisation of cyst of liver
+∞
35.0
33
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
97.0
32.4
35
*
L04AX01
ATC
azathioprine; systemic
8.8
32.2
43
55
Q44.29
ICD-10 Finland
Atresia of bile ducts
+∞
31.8
30
*
JAH00
NOMESCO Finland
Laparotomy
9.8
31.3
38
43
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
175.6
31.2
32
*
JKD50
NOMESCO Finland
Hepatoportoenterostomy
+∞
30.7
29
*
JJ5KT
NOMESCO Finland
Sclerotherapy of liver cyst
+∞
30.7
29
*
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
32.1
30.6
40
14
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
7.9
28.2
41
58
H02AB04
ATC
methylprednisolone; systemic
4.1
26.8
89
267
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.8
26.6
69
171
WX302
NOMESCO Finland
Thoracal epidural anesthesy
7.3
25.7
40
61
WX402
NOMESCO Finland
General anaesthesia
3.4
25.4
132
531
RD210, ,
NOMESCO Finland
7.9
25.1
36
50
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.1
24.3
184
919
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
9.5
23.6
29
33
TPH07
NOMESCO Finland
Cathetrisation of artery
4.1
23.4
75
218
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
22.8
203
1098
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
6.1
22.6
42
77
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
41.6
22.1
27
7
Z2446
NOMESCO Finland
Social worker
4.1
21.3
66
186
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
23.3
21.2
30
14
Q44.20
ICD-10 Finland
Atresia of intrahepatic bile ducts
+∞
21.0
20
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
5.9
21.0
40
75
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
32.4
20.9
27
9
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.5
20.5
42
84
H02AB09
ATC
hydrocortisone; systemic
6.9
20.5
33
52
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
20.4
91
328
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
7.5
20.3
30
43
Q44.4
ICD-10 Finland
Choledochal cyst
+∞
20.0
19
*
JJ5AT, ,
NOMESCO Finland
211.5
19.8
20
*
R50.9
ICD-10 Finland
Fever, unspecified
3.3
19.7
95
359
TPH04
NOMESCO Finland
Cathetrisation of vein
3.1
19.6
109
448
Z49.1
ICD-10 Finland
Extracorporeal dialysis
25.4
18.9
26
11
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
18.9
137
648
JCA32
NOMESCO Finland
Endoscopic injection in oesophagus
105.8
18.8
20
*
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
26.8
18.5
25
10
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
24.4
18.0
25
11
A12AA04
ATC
calcium carbonate; oral
15.7
18.0
29
20
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.4
17.8
48
121
B03XA02
ATC
darbepoetin alfa; parenteral
15.1
17.1
28
20
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
6.9
16.9
27
42
R4110
NOMESCO Finland
Physiotherapy
2.6
16.5
139
701
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
31.8
16.3
21
7
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
22.3
16.2
23
11
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
6.1
16.1
29
51
J01MA02
ATC
ciprofloxacin; systemic
2.6
16.1
152
808
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.8
16.1
38
86
JJ1AT
NOMESCO Finland
Puncture of lesion of liver with ultrasound guidance
167.2
15.6
16
*
ZXD05
NOMESCO Finland
Urgent procedure
2.6
15.6
131
657
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.3
15.4
65
224
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
24.7
15.3
21
9
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
12.1
15.1
27
24
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
33.4
15.0
19
6
Z49.0
ICD-10 Finland
Preparatory care for dialysis
33.4
15.0
19
6
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
11.6
14.8
27
25
N18.8
ICD-10 Finland
Other chronic renal failure
12.1
14.5
26
23
205
Kela drug reimbursment
Chronic hypertension
2.6
14.4
105
488
JN4AD
NOMESCO Finland
Body CT examination
3.6
13.9
51
160
C03CA01
ATC
furosemide; systemic
2.5
13.6
116
579
Q44.1
ICD-10 Finland
Other congenital malformations of gallbladder
+∞
13.6
13
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
13.6
158
907
N02AX02
ATC
tramadol; systemic, rectal
2.3
13.4
164
960
R4190
NOMESCO Finland
Nutritional therapy
3.5
13.0
48
151
Q44.0
ICD-10 Finland
Agenesis, aplasia and hypoplasia of gallbladder
+∞
12.6
12
*
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
+∞
12.6
12
*
Q44.3
ICD-10 Finland
Congenital stenosis and stricture of bile ducts
+∞
12.6
12
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.8
12.5
41
119
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
15.1
12.4
20
14
ZXE00
NOMESCO Finland
One hour or less
2.3
12.3
166
1003
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.6
12.2
86
390
C08CA02
ATC
felodipine; oral
3.6
12.1
42
127
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.2
12.0
51
175
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.2
12.0
53
187
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.4
11.9
46
149
K83.1
ICD-10 Finland
Obstruction of bile duct
13.2
11.8
20
16
V03AE02
ATC
sevelamer; oral
31.2
11.7
15
5
ZXE40
NOMESCO Finland
More than seven and less than nine hours
5.5
11.7
23
44
ZYB02
NOMESCO Finland
Outreach service at unit of another specialty
19.8
11.7
17
9
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
11.6
159
961
Q44.78
ICD-10 Finland
Other congenital malformations of the liver
+∞
11.5
11
*
7531A
ICD-9 Finland
Congenital anomalies of urinary system, Cystic kidney disease
+∞
11.5
11
*
BE00A, ,
NOMESCO Finland
+∞
11.5
11
*
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
12.4
11.5
20
17
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
20.9
11.2
16
8
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
9.0
11.2
23
27
XF602
NOMESCO Finland
Bloodpressure monitoring
14.5
11.1
18
13
WX882
NOMESCO Finland
High dependency care
3.9
11.0
33
90
L04AA01
ATC
[U] ciclosporin
18.6
10.8
16
9
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
8.4
10.8
23
29
Q44.75
ICD-10 Finland
Focal nodular hypoplasia of the liver
+∞
10.5
10
*
JJC10
NOMESCO Finland
Allogenic partial transplantation of liver
+∞
10.5
10
*
K00.81
ICD-10 Finland
Color changes in the teeth caused by biliary anomalies
+∞
10.5
10
*
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
33.6
10.4
13
*
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
7.9
10.4
23
31
N18.0
ICD-10 Finland
End-stage renal disease
24.2
10.3
14
6
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
10.5
10.1
19
19
V03AE01
ATC
polystyrene sulfonate; oral
15.2
10.1
16
11
C03DA01
ATC
spironolactone; oral
2.8
10.0
54
212
Z3226
NOMESCO Finland
Physiotherapist
2.3
10.0
91
460
R18
ICD-10 Finland
Ascites
11.1
9.9
18
17
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.3
9.7
86
429
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
11.8
9.7
17
15
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.9
9.6
29
79
UJF32
NOMESCO Finland
Coloscopy
2.2
9.5
101
544
JN3DG
NOMESCO Finland
Very extensive MRI examination with high intensity magnet
31.0
9.5
12
*
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
31.0
9.5
12
*
5AB14, ,
NOMESCO Finland
31.0
9.5
12
*
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.6
9.4
32
95
A41.9
ICD-10 Finland
Sepsis, unspecified
4.9
9.4
21
45
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
22.4
9.4
13
6
Q61.1
ICD-10 Finland
Polycystic kidney, autosomal recessive
+∞
9.4
9
*
Z2221
NOMESCO Finland
Medical doctor
2.1
9.4
114
647
TPX10
NOMESCO Finland
Implantation of vascular injection port
5.0
9.2
20
42
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
4.1
9.1
26
68
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
4.1
9.1
26
68
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
37.7
9.1
11
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
7.8
9.1
20
27
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
51.3
8.7
10
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.7
8.6
51
210
ZX120
NOMESCO Finland
Intravenous
2.7
8.6
50
204
Q61.0
ICD-10 Finland
Congenital single renal cyst
92.2
8.4
9
*
A41.8
ICD-10 Finland
Other specified sepsis
8.9
8.4
17
20
JJA30
NOMESCO Finland
Marsupialisation of cyst of liver
+∞
8.4
8
*
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
+∞
8.4
8
*
UJF30
NOMESCO Finland
Ileoscopy through colon
2.8
8.3
45
177
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.1
8.3
97
539
602
Kela drug reimbursment
Children's severe malnutrition
7.1
8.2
19
28
B01AB04
ATC
dalteparin; parenteral
3.9
8.0
24
65
J01MA12
ATC
levofloxacin; systemic
2.3
8.0
68
332
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.8
8.0
18
39
C08CA01
ATC
amlodipine; oral
2.0
8.0
131
821
137
Kela drug reimbursment
Uraemia requiring dialysis
13.4
7.9
13
10
ZXE20
NOMESCO Finland
More than three and less than five hours
2.3
7.8
64
307
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.6
7.8
50
214
Z94.9
ICD-10 Finland
Transplanted organ and tissue status, unspecified
46.0
7.7
9
*
JJA20
NOMESCO Finland
Open biopsy of liver
46.0
7.7
9
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
7.0
7.7
18
27
WX002
NOMESCO Finland
Sedation and analgesia
2.2
7.7
76
395
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
18.9
7.6
11
6
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
12.2
7.6
13
11
KAC00
NOMESCO Finland
Nephrectomy
25.6
7.6
10
*
K83.5
ICD-10 Finland
Biliary cyst
81.8
7.4
8
*
JK3AN
NOMESCO Finland
Biliary tract isotope imaging
81.8
7.4
8
*
Q61.99
ICD-10 Finland
Cystic kidney disease, unspecified
81.8
7.4
8
*
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
81.8
7.4
8
*
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
81.8
7.4
8
*
Q44.5
ICD-10 Finland
Other congenital malformations of bile ducts
+∞
7.3
7
*
7516D
ICD-9 Finland
Other congenital anomalies of digestive system, Anomalies of gallbladder, bile ducts and liver[HEPAR POLYCYSTICUM]
+∞
7.3
7
*
C02AC05
ATC
moxonidine; oral
4.1
7.3
20
51
D97
ICPC
Liver disease NOS
30.7
7.2
9
*
V03AG01
ATC
sodium cellulose phosphate; systemic
30.7
7.2
9
*
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
30.7
7.2
9
*
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
30.7
7.2
9
*
UJK02
NOMESCO Finland
ERCP
5.8
7.2
19
34
V03AE03
ATC
lanthanum carbonate; oral
20.5
7.2
10
5
3AC01, ,
NOMESCO Finland
12.4
7.1
12
10
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.5
7.0
48
212
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
7.0
84
469
C07AG02
ATC
carvedilol; oral
3.2
6.9
28
93
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
14.1
6.9
11
8
WX892
NOMESCO Finland
Monitored bed care
2.8
6.9
35
133
4AA09, ,
NOMESCO Finland
40.9
6.8
8
*
K06.19
ICD-10 Finland
Gingival hyperplasia UNS
17.1
6.8
10
6
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.1
6.6
66
343
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.7
6.5
21
60
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
3.4
6.4
23
71
Z3231
NOMESCO Finland
Registered nurse
1.8
6.3
115
735
A02BC02
ATC
pantoprazole; systemic
1.8
6.3
220
1702
UKC02
NOMESCO Finland
Cystoscopy
2.3
6.3
50
236
KBV00
NOMESCO Finland
Insertion of stent into ureter
18.4
6.3
9
5
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
18.4
6.3
9
5
T86.4
ICD-10 Finland
Liver transplant failure and rejection
+∞
6.3
6
*
JCA35
NOMESCO Finland
Endoscopic contact coagulation in oesophagus
+∞
6.3
6
*
75310
ICD-8 Finland
Congenital anomalies of urinary system, Ren polycysticus bilateralis
+∞
6.3
6
*
TK810
NOMESCO Finland
Hemofiltration
27.2
6.3
8
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
80
44
23.31
103.37
3.4
3.3
16.18
96.94
u/ml
0.46
80
44
169
342
8.66
89.79
22.8
3.3
8.33
7.06
umol/l
0.45
163
293
61
32
22.90
79.81
13.4
2.8
93.98
99.22
%
0.46
61
32
75
63
14.90
77.19
12.5
8.1
397.78
175.56
iu/ml
—
23
9
83
111
9.51
61.34
3.0
3.1
222.09
1568.02
u/ml
0.57
76
98
61
54
13.48
60.31
11.8
5.6
476.13
549.56
u/ml
—
8
9
43
22
22.16
56.36
9.0
2.3
21.09
28.41
umol/l
2.33
43
22
50
38
15.20
53.92
16.8
1.9
36.35
11.39
umol/l
1.79
50
27
267
1191
6.34
53.52
17.9
5.2
35.66
36.06
g/l
0.62
260
1128
87
150
7.40
51.14
17.7
13.0
1.51
1.20
mg/l
2.53
87
144
292
1458
7.23
49.77
24.0
6.6
13.54
13.91
umol/l
0.12
287
1383
42
28
16.92
48.47
2.7
1.5
—
—
—
0
0
62
81
9.10
46.16
2.3
1.9
268.34
199.73
u/ml
0.60
53
33
62
82
8.98
45.69
2.2
1.9
—
—
—
0
0
61
83
8.70
43.86
2.8
1.7
—
—
—
0
0
254
1227
4.96
42.12
15.8
11.4
1.15
1.22
inr
0.90
65
357
59
82
8.46
41.61
2.8
1.7
124.00
87.87
u/ml
—
8
10
129
391
4.65
39.80
6.6
2.5
19.65
22.11
%
1.49
117
343
193
850
3.85
34.23
5.3
2.4
76.78
60.36
u/l
0.59
178
787
35
34
11.33
32.08
2.1
1.6
—
—
—
0
0
139
532
3.69
29.68
5.4
3.0
0.49
0.95
e6/l
2.86
103
299
90
255
4.41
29.45
6.1
2.2
47.54
29.07
u/l
2.07
78
211
321
2143
7.42
29.02
23.8
7.2
122.79
89.03
u/l
6.34
315
2017
162
692
3.51
29.01
4.6
2.4
—
—
—
0
0
94
284
4.16
28.12
3.1
4.2
3.83
24.20
ug/l
0.77
68
238
246
1392
3.62
27.30
25.5
7.7
1.21
1.22
mmol/l
1.27
239
1281
254
1485
3.63
26.34
26.5
7.9
1.21
1.22
mmol/l
2.58
237
1295
282
1780
4.08
25.56
18.8
3.3
97.97
43.76
u/l
6.54
271
1669
127
504
3.39
24.95
5.5
3.3
1.74
2.46
e6/l
0.59
93
277
94
316
3.71
23.80
14.4
7.6
104.89
103.91
mmol/l
0.98
94
316
147
666
3.09
22.72
6.7
3.1
333.76
5979.34
umol/l
2.64
138
583
224
1281
3.10
22.72
4.9
2.6
—
—
—
0
0
197
1066
2.95
21.81
8.6
3.4
—
—
—
0
0
95
342
3.45
21.45
26.4
10.4
24.26
24.85
mmol/l
1.28
95
342
33
53
6.77
20.11
12.3
11.3
78.48
63.65
%
3.57
33
53
28
13
23.29
19.83
6.1
3.8
—
—
—
0
0
166
852
2.81
19.78
8.5
3.4
0.10
0.40
e6/l
3.77
142
628
71
225
3.71
19.35
3.2
2.8
48.96
68.56
ml/min/173m2
2.27
26
94
36
66
5.97
19.27
1.5
1.2
—
—
—
0
0
173
924
2.73
18.84
8.3
3.5
20.21
110.40
e6/l
0.68
149
700
207
1212
2.75
18.73
6.5
2.6
80.24
76.97
nmol/l
1.04
200
1087
61
184
3.81
17.79
1.8
1.5
—
—
—
0
0
28
44
6.83
17.37
1.2
1.1
—
—
—
0
0
48
128
4.19
16.56
13.4
10.9
—
—
—
0
0
81
306
3.15
16.54
2.6
1.7
—
—
—
0
0
158
853
2.56
16.22
5.0
3.6
6.26
7.26
mmol/l
2.34
150
731
100
431
2.85
16.10
2.6
1.8
—
—
—
0
0
252
1702
2.74
16.01
15.9
5.3
6.36
6.51
mmol/l
0.69
247
1595
80
307
3.09
15.86
2.7
1.8
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
34
74
4.98
15.05
11.7
12.6
0.30
0.34
u/ml
0.36
18
42
71
273
3.01
13.91
12.1
7.9
-0.14
1.10
mmol/l
2.04
61
227
253
1780
2.54
13.61
19.2
9.8
3.94
3.92
e9/l
0.06
231
1529
196
1248
2.31
13.03
5.8
2.8
117.05
101.99
ug/l
0.69
189
1156
219
1467
2.33
12.82
17.3
6.8
2.94
2.93
%
0.01
209
1384
23
21
11.64
12.72
4.2
1.6
0.87
1.04
g/l
0.85
23
21
130
707
2.34
12.43
3.7
2.5
2.86
3.14
mg/l
0.81
109
609
220
1491
2.29
12.32
17.0
6.7
57.39
54.73
%
2.30
211
1414
45
143
3.47
12.00
2.3
1.6
—
—
—
0
0
137
774
2.27
11.86
2.0
1.7
1.11
1.35
mmol/l
4.64
130
659
221
1515
2.26
11.84
17.4
6.8
27.99
30.31
%
1.99
212
1437
15
5
31.24
11.74
1.0
1.2
—
—
—
0
0
17
9
19.78
11.70
1.1
1.1
—
—
—
0
0
42
132
3.48
11.38
13.2
6.4
0.60
0.66
%
0.31
42
132
69
292
2.70
11.18
2.7
1.8
1.62
1.49
%
0.55
64
257
208
1417
2.16
10.98
6.6
3.7
0.00
0.00
estimate
0.50
40
279
115
628
2.24
10.61
8.0
2.5
1.76
1.37
mg/l
0.46
92
493
209
1438
2.14
10.60
6.6
3.7
0.00
0.01
estimate
0.50
42
254
207
1423
2.12
10.48
9.1
5.0
0.00
0.00
estimate
-0.00
41
259
20
23
9.15
9.92
1.4
1.4
—
—
—
0
0
14
7
20.76
9.88
4.1
6.4
—
—
—
0
0
28
78
3.82
9.03
2.5
1.6
—
—
—
0
0
272
2152
2.21
8.61
8.6
4.3
14.28
11.64
mm/h
2.09
263
1998
59
269
2.44
8.08
3.8
3.4
—
—
—
0
0
312
2653
2.70
7.78
6.5
4.4
4.41
4.71
mmol/l
6.06
300
2465
309
2622
2.59
7.62
48.4
16.5
14.41
14.77
%
0.86
303
2597
331
2913
3.79
7.58
41.7
13.1
21.19
22.28
mg/l
0.32
298
2218
315
2699
2.76
7.58
6.8
4.9
2.53
2.78
mmol/l
6.71
300
2493
26
83
3.30
6.87
1.6
1.3
—
—
—
0
0
89
513
1.99
6.74
3.9
3.8
454.00
336.33
ng/l
0.18
76
386
17
41
4.31
6.62
1.5
1.2
—
—
—
0
0
121
777
1.85
6.60
5.6
3.7
10.39
9.98
mg/mmol
0.04
93
473
65
337
2.14
6.53
22.6
7.6
0.96
1.47
mmol/l
1.06
46
249
139
938
1.80
6.41
5.2
3.3
2.36
2.36
mmol/l
0.04
126
837
305
2641
2.25
6.01
6.3
4.4
1.48
1.51
mmol/l
0.46
290
2437
335
3050
3.63
5.60
38.9
15.0
92.59
70.24
umol/l
5.27
335
3050
13
23
5.83
5.11
2.4
10.6
40.90
544.33
g/mol
0.63
13
18
18
56
3.34
4.96
12.2
2.9
4.83
5.02
kpa
0.57
18
56
21
72
3.04
4.96
2.0
1.3
—
—
—
0
0
21
72
3.04
4.96
2.0
1.3
—
—
—
0
0
143
1034
1.65
4.82
2.2
2.0
94.88
95.59
pmol/l
0.06
77
505
291
2542
1.88
4.62
5.9
4.0
1.17
1.26
mmol/l
1.58
274
2341
14
31
4.66
4.61
1.1
1.2
—
—
—
0
0
14
31
4.66
4.61
1.1
1.2
—
—
—
0
0
14
32
4.51
4.49
1.1
1.2
—
—
—
0
0
14
32
4.51
4.49
1.1
1.2
—
—
—
0
0
14
32
4.51
4.49
1.1
1.2
—
—
—
0
0
15
46
3.36
4.24
4.7
2.8
3.35
4.68
e9/l
1.19
15
46
22
85
2.70
4.23
2.3
2.1
—
—
—
0
0
33
156
2.23
4.15
1.7
1.3
—
—
—
0
0
24
98
2.56
4.15
1.5
1.4
222.81
300.09
ug/g
0.94
16
57
15
47
3.29
4.10
5.5
3.1
55.80
57.51
%
0.17
15
47
94
635
1.66
4.01
1.8
1.5
19.56
22.01
nmol/l
1.12
85
530
232
1941
1.59
3.93
3.4
3.2
—
—
—
0
0
6
5
12.18
3.77
3.0
1.0
—
—
—
0
0
281
2480
1.69
3.66
29.0
12.2
73.58
81.78
ml/min/173m2
4.41
231
1990
283
2506
1.69
3.60
8.1
5.6
38.15
39.55
mmol/mol
1.90
274
2338
8
13
6.27
3.52
1.1
1.5
—
—
—
0
0
7
10
7.12
3.38
1.1
1.0
1841.00
1351.30
miu/ml
—
7
10
293
2637
1.70
3.28
5.6
4.4
5.76
5.88
mmol/l
0.70
277
2426
6
7
8.69
3.27
5.5
5.6
—
—
—
0
0
8
15
5.43
3.21
2.1
3.9
180.19
135.20
ug/l
—
8
15
17
69
2.54
3.00
1.1
1.2
—
—
—
0
0
16
63
2.61
3.00
2.6
1.6
—
—
—
0
0
339
3245
2.73
2.93
55.4
19.8
239.34
257.63
e9/l
4.54
332
3156
339
3244
2.74
2.93
57.6
20.0
38.40
39.78
%
5.69
319
3091
137
1071
1.46
2.90
6.7
3.7
—
—
—
0
0
6
9
6.76
2.88
1.2
1.1
—
—
—
0
0
18
77
2.41
2.87
1.8
1.5
0.00
0.05
iu/ml
—
6
14
20
90
2.30
2.86
1.7
2.2
119.26
286.29
ug/l
1.41
20
82
107
800
1.49
2.83
2.0
2.1
149.06
194.69
u/l
0.68
99
755
87
623
1.53
2.83
6.4
3.8
1.02
1.02
kg/l
0.36
11
95
103
766
1.49
2.79
7.8
3.9
0.00
0.00
estimate
-0.00
40
259
339
3247
2.70
2.79
55.4
19.7
4.35
4.49
e12/l
5.47
333
3149
66
446
1.59
2.76
1.9
1.7
1086.74
1233.45
nmol/l
0.80
51
329
71
499
1.53
2.50
3.6
2.7
2.47
2.45
mmol/l
0.77
64
442
12
45
2.73
2.47
2.1
1.6
—
—
—
0
0
65
451
1.54
2.42
1.6
1.5
—
—
—
0
0
18
85
2.18
2.33
1.1
1.3
—
2.94
—
0
14
11
40
2.81
2.29
1.9
3.0
—
—
—
0
0
10
35
2.91
2.22
2.3
1.9
—
—
—
0
0
5
9
5.62
2.22
1.0
1.1
—
—
—
0
0
20
102
2.02
2.15
1.2
1.1
—
—
—
0
0
20
103
2.00
2.10
1.2
1.1
—
—
—
0
0
18
89
2.08
2.10
1.1
1.3
—
2.27
—
0
6
6
15
4.05
2.04
1.5
1.1
42.48
23.60
u/l
—
6
15
6
15
4.05
2.04
1.5
1.1
108.43
76.53
u/l
—
6
15
8
26
3.12
2.02
1.3
2.6
3.81
3.22
nmol/l
—
8
26
13
57
2.33
2.00
3.7
1.8
—
—
—
0
0
13
57
2.33
2.00
3.7
1.8
—
—
—
0
0
16
77
2.13
2.00
2.5
1.7
—
—
—
0
0
7
21
3.38
1.97
1.3
2.9
—
—
—
0
0
12
51
2.40
1.97
2.3
1.6
—
—
—
0
0
8
27
3.01
1.94
1.3
1.1
—
—
—
0
0
8
28
2.90
1.87
1.3
1.1
—
—
—
0
0
6
17
3.57
1.84
1.7
2.6
1704.50
751.53
u/ml
—
6
17
15
73
2.10
1.83
3.4
1.8
—
—
—
0
0
15
73
2.10
1.83
3.4
1.8
—
—
—
0
0
18
95
1.94
1.79
3.6
1.7
—
—
—
0
0
12
54
2.27
1.76
2.3
1.7
—
—
—
0
0
6
18
3.37
1.75
2.3
1.3
—
—
—
0
0
8
32
2.53
1.60
1.0
1.2
—
—
—
0
0
10
44
2.31
1.57
1.0
1.1
—
—
—
0
0
17
94
1.85
1.50
5.1
1.7
—
—
—
0
0
18
104
1.77
1.40
1.6
1.9
—
—
—
0
0
18
105
1.75
1.36
1.7
2.1
—
—
—
0
0
0
38
0.00
1.35
0.0
1.6
—
—
—
0
0
113
949
1.28
1.35
3.0
3.8
72.17
28.75
ng/l
0.37
80
643
20
121
1.69
1.34
1.3
1.6
—
—
—
0
0
5
18
2.80
1.29
5.2
2.7
910.00
598.11
ml
—
5
9
5
18
2.80
1.29
2.0
1.6
0.80
4.14
u/field
—
5
7
10
48
2.12
1.29
1.1
1.1
—
—
—
0
0
11
55
2.03
1.28
1.4
1.3
—
—
—
0
0
6
25
2.42
1.25
4.8
3.8
—
—
—
0
0
10
50
2.03
1.17
1.8
1.5
—
—
—
0
0
0
33
0.00
1.16
0.0
1.3
—
—
—
0
0
0
33
0.00
1.16
0.0
1.3
—
—
—
0
0
0
33
0.00
1.16
0.0
1.3
—
—
—
0
0
16
95
1.72
1.16
1.9
1.5
—
—
—
0
0
5
21
2.40
1.09
3.2
1.3
—
—
—
0
0
11
59
1.89
1.08
1.5
1.3
—
—
—
0
0
16
98
1.66
1.05
1.6
1.8
—
—
—
0
0
38
499
0.73
1.02
1.3
1.3
10.15
39.08
iu/ml
5.24
11
159
16
100
1.63
0.98
1.3
1.5
—
—
—
0
0
5
23
2.19
0.98
2.0
2.8
—
—
—
0
0
5
23
2.19
0.98
2.0
2.8
—
—
—
0
0
41
316
1.34
0.92
14.7
6.6
—
—
—
0
0
25
344
0.71
0.90
5.8
4.4
36.20
32.16
%
1.50
20
223
90
770
1.23
0.90
2.6
3.8
1762.58
1109.73
ng/l
0.60
81
659
56
457
1.27
0.84
3.9
4.4
26.13
20.71
%
1.56
26
224
30
224
1.37
0.83
1.2
1.3
126.13
135.36
iu/ml
—
9
89
6
32
1.89
0.82
1.2
1.4
—
—
—
0
0
0
24
0.00
0.79
0.0
1.0
—
83.79
—
0
24
11
67
1.66
0.76
1.5
1.5
—
—
—
0
0
5
24
2.10
0.75
5.6
5.2
4.07
1.68
ug/l
—
5
24
21
151
1.42
0.73
2.4
3.0
0.12
0.16
e6/l
0.23
21
146
7
39
1.81
0.73
4.7
1.6
—
—
—
0
0
25
191
1.33
0.63
1.0
1.1
—
—
—
0
0
12
80
1.52
0.60
1.4
1.3
63.71
292.77
miu/ml
—
7
36
22
166
1.35
0.60
1.4
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
12
173
0.68
0.59
1.8
2.0
14.03
12.47
nmol/l
0.23
12
155
9
60
1.51
0.54
1.4
1.3
—
—
—
0
0
7
45
1.57
0.49
4.7
1.5
—
—
—
0
0
65
576
1.16
0.46
4.0
4.9
1.87
2.58
ug/l
0.62
59
521
5
31
1.62
0.43
2.2
1.6
—
—
—
0
0
5
31
1.62
0.43
2.2
1.6
—
—
—
0
0
5
31
1.62
0.43
2.2
1.6
—
—
—
0
0
6
92
0.65
0.43
1.2
1.5
267.83
302.33
mu/l
—
6
85
274
2662
1.14
0.42
4.6
4.7
1.93
2.39
mu/l
0.49
260
2444
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
60
534
1.15
0.41
1.5
1.7
534.44
452.91
pmol/l
0.98
54
452
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
15
116
1.31
0.37
1.7
1.6
—
—
—
0
0
43
488
0.86
0.36
1.4
1.3
1.46
11.66
u/ml
2.48
17
183
13
99
1.33
0.36
1.7
1.4
—
—
—
0
0
234
2263
1.10
0.35
3.9
4.0
14.83
14.70
pmol/l
0.35
225
2073
6
88
0.68
0.33
1.7
1.7
—
—
—
0
0
12
95
1.27
0.26
1.2
1.1
—
14.76
—
0
16
8
67
1.20
0.26
1.8
1.4
—
—
—
0
0
5
73
0.68
0.26
1.0
1.0
3.12
3.44
kpa
—
5
56
5
74
0.67
0.26
1.0
1.0
7.24
7.45
kpa
—
5
57
38
341
1.13
0.25
2.9
2.9
0.69
0.77
ug/l
0.23
27
224
9
77
1.17
0.24
1.1
2.5
3.40
3.78
mmol/l
—
9
71
71
662
1.09
0.24
1.8
1.8
—
—
—
0
0
5
41
1.22
0.22
1.6
1.4
0.48
0.55
nmol/l
—
5
36
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
85
808
1.07
0.18
1.3
1.5
2.34
2.62
u/ml
0.08
15
188
7
58
1.21
0.18
4.9
1.5
—
—
—
0
0
23
256
0.89
0.16
2.0
1.9
—
—
—
0
0
5
44
1.14
0.10
3.0
1.5
—
—
—
0
0
5
62
0.80
0.08
1.0
1.1
—
—
—
0
0
16
147
1.09
0.07
1.9
1.6
—
—
—
0
0
11
100
1.10
0.05
1.1
1.3
—
—
—
0
0
10
109
0.91
0.04
1.1
1.1
—
—
—
0
0
22
226
0.97
0.00
1.4
1.7
—
—
—
0
0
28
282
0.99
0.00
1.9
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
78
0.90
-0.00
1.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
8
80
1.00
-0.00
2.5
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.1
—
198.07
—
0
14
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER | 1.328 [1.1, 1.6] | 0.003 |
| Birth year | 1.002 [0.99, 1.01] | 0.663 |
During the follow-up period (1.1.1998 — 31.12.2019), 200 out of 1032 females with Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER | 1.368 [1.01, 1.86] | 0.044 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 130 out of 506 males with Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.181% | 0.232% |
| 5 | 1.032% | 1.42% |
| 10 | 2.439% | 3.794% |
| 15 | 4.731% | 7.375% |
| 20 | 8.411% | 12.237% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER – Congenital malformations of gallbladder, bile ducts and liver
GWS hits: 23
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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