No definition available.
Congenital malformations of pulmonary and tricuspid valves
Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
279 |
4. Check minimum number of eventsNone |
279 |
5. Include endpointsNone |
279 |
6. Filter based on genotype QC (FinnGen only) |
279 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_CIRCULATO_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q2
- Name in latin
- Malformationes congenitae valvae (trunci) pulmonalis et valvae tricuspidalis
Similar endpoints
↥List of similar endpoints to
Congenital malformations of pulmonary and tricuspid valves
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations of the circulatory system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3353 | 1847 | 1493 |
| Only index persons | 2303 | 1282 | 1021 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 1.11 | 1.00 | 0.99 |
| Only index persons | 6.33 | 6.78 | 5.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 279 | 163 | 116 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.05 |
| Median age at first event (years) | 10.49 | 14.33 | 5.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 261
- Matched controls
- 2602
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
193.6
161
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
82.3
93.2
102
20
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
102.0
87.6
93
14
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
18.6
87.0
155
189
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
21.6
81.6
130
114
XF400
NOMESCO Finland
ECG with 12 standard connections
12.4
64.7
138
216
201
Kela drug reimbursment
Chronic cardiac insufficiency
54.5
58.7
69
17
XF404
NOMESCO Finland
Ambulatory ECG
19.2
58.6
94
74
Q21.10
ICD-10 Finland
Persistent ostium secundum
+∞
56.3
52
*
XF402
NOMESCO Finland
ECG with work load test
20.8
52.1
80
54
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
78.5
50.6
56
9
C03DA01
ATC
spironolactone; oral
23.1
49.6
73
43
Q22.5
ICD-10 Finland
Ebstein anomaly
+∞
48.4
45
*
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
+∞
48.4
45
*
B01AA03
ATC
warfarin; systemic
18.3
46.7
75
56
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
102.5
46.7
50
6
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
14.4
45.8
82
80
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
+∞
44.0
41
*
C03CA01
ATC
furosemide; systemic
10.7
43.3
92
126
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.6
43.2
157
486
FM2CE
NOMESCO Finland
NA
19.6
43.2
67
45
31
HP
Congenital heart failure surgery
+∞
42.9
40
*
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
+∞
41.8
39
*
TPH07
NOMESCO Finland
Cathetrisation of artery
12.1
41.6
81
93
I37.0
ICD-10 Finland
Pulmonary valve stenosis
+∞
39.6
37
*
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
156.3
38.9
40
*
Q22.0
ICD-10 Finland
Pulmonary valve atresia
+∞
37.4
35
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
214.0
36.8
37
*
61
HP
Catheterization and pressure measurement of the left side of the heart
214.0
36.8
37
*
C01AA05
ATC
digoxin; systemic
38.1
33.4
42
13
62
HP
Catheterization and pressure measurement of the right side of the heart
+∞
31.9
30
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.1
31.4
87
172
WX408
NOMESCO Finland
General anesthesy, balanced
4.9
29.9
131
445
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
325.6
29.4
29
*
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
80.8
26.3
29
*
Z98.8
ICD-10 Finland
Other specified postsurgical states
56.1
25.8
30
6
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
25.4
24
*
Q20.48
ICD-10 Finland
Single ventricle
+∞
24.3
23
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
8.9
23.9
53
72
XF600
NOMESCO Finland
Bloodpressure measurement
7.0
23.4
62
111
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
91.7
23.1
25
*
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
131.3
23.0
24
*
WX872
NOMESCO Finland
Intensive care
20.7
22.4
33
18
WX882
NOMESCO Finland
High dependency care
7.2
22.2
57
97
Q21.30
ICD-10 Finland
Tetralogy of Fallot
+∞
22.2
21
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
18.7
21.6
33
20
XF622
NOMESCO Finland
Measurement of minute volume of heart
+∞
21.1
20
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
29.8
20.5
27
10
Q22.2
ICD-10 Finland
Congenital pulmonary valve insufficiency
+∞
20.0
19
*
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
+∞
20.0
19
*
Q21.19
ICD-10 Finland
Atrial septal defect NOS
+∞
20.0
19
*
7460C
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITA CUM STENOSIS]
+∞
20.0
19
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
27.1
20.0
27
11
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
+∞
19.0
18
*
74663
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae pulmonalis
+∞
19.0
18
*
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
+∞
19.0
18
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.7
18.5
103
394
TFP20
NOMESCO Finland
Cardiodefibrillation
15.2
18.3
30
22
Q20.1
ICD-10 Finland
Double outlet right ventricle
+∞
17.9
17
*
Q25.0
ICD-10 Finland
Patent ductus arteriosus
+∞
17.9
17
*
Q22.41
ICD-10 Finland
Tricuspid atresia
+∞
17.9
17
*
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
45.4
17.5
21
5
R4110
NOMESCO Finland
Physiotherapy
3.4
17.2
106
433
XFE00
NOMESCO Finland
Epicardial ultrasonography
23.8
17.2
24
11
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
16.8
16
*
Q87.14
ICD-10 Finland
Noonan's syndrome
+∞
16.8
16
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
6.1
16.8
48
93
I48
ICD-10 Finland
Atrial fibrillation and flutter
7.0
16.6
42
69
WX892
NOMESCO Finland
Monitored bed care
5.7
16.2
49
102
I37.2
ICD-10 Finland
Pulmonary valve stenosis with insufficiency
+∞
15.8
15
*
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
+∞
15.8
15
*
FJD20
NOMESCO Finland
Bypass of pulmonary valve with ventriculopulmonary prosthesis or homograft
+∞
15.8
15
*
I44.2
ICD-10 Finland
Atrioventricular block, complete
47.9
15.2
18
*
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
+∞
14.7
14
*
Q21.32
ICD-10 Finland
Pulmonary atresia with Fallot ventricular septal defect
+∞
14.7
14
*
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
18.8
14.1
21
12
FJF10
NOMESCO Finland
Replacement of pulmonary valve using biological prosthesis
+∞
13.6
13
*
FJE42
NOMESCO Finland
Percutaneous transluminal expansion of pulmonary valve
+∞
13.6
13
*
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
+∞
13.6
13
*
C01BD01
ATC
amiodarone; systemic
27.4
13.5
18
7
207
Kela drug reimbursment
Chronic arrhythmias
7.3
13.3
32
49
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
+∞
12.6
12
*
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
+∞
12.6
12
*
Q23.11
ICD-10 Finland
Bicuspid aortic valve
+∞
12.6
12
*
Q22.3
ICD-10 Finland
Other congenital malformations of pulmonary valve
+∞
12.6
12
*
1EA01
NOMESCO Finland
NA
+∞
12.6
12
*
XF620
NOMESCO Finland
Examination of circulation with color method
136.0
12.5
13
*
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
136.0
12.5
13
*
G04BE03
ATC
sildenafil; oral
24.2
11.7
16
7
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
+∞
11.5
11
*
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
+∞
11.5
11
*
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
+∞
11.5
11
*
Q22.40
ICD-10 Finland
Congenital tricuspid stenosis
+∞
11.5
11
*
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
+∞
11.5
11
*
Q25.1
ICD-10 Finland
Coarctation of aorta
+∞
11.5
11
*
7AX01
NOMESCO Finland
NA
36.7
11.4
14
*
ZX120
NOMESCO Finland
Intravenous
4.4
11.0
41
106
RS224
NOMESCO Finland
NA
16.4
11.0
17
11
TPH04
NOMESCO Finland
Cathetrisation of vein
3.1
10.9
68
268
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.2
10.8
64
243
C07AA07
ATC
sotalol; systemic
15.0
10.6
17
12
Q22.6
ICD-10 Finland
Hypoplastic right heart syndrome
+∞
10.5
10
*
FFC00
NOMESCO Finland
Suture of ostium secundum type ASD
+∞
10.5
10
*
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
10.5
10
*
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
+∞
10.5
10
*
FM1BD
NOMESCO Finland
Extensive CT of heart
103.4
9.5
10
*
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
+∞
9.4
9
*
Q21.21
ICD-10 Finland
Atrioventricular duct
+∞
9.4
9
*
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
+∞
9.4
9
*
7455A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ostium secundum type atrial septal defect
+∞
9.4
9
*
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
+∞
9.4
9
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
9.4
9
*
XQ903
NOMESCO Finland
Production of other scan or drawing
+∞
9.4
9
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
6.7
9.0
22
35
602
Kela drug reimbursment
Children's severe malnutrition
6.3
9.0
23
39
WZC30
NOMESCO Finland
Teaching
3.7
8.7
39
119
ZX199
NOMESCO Finland
Other rote
12.1
8.7
15
13
XF640
NOMESCO Finland
NA
20.8
8.5
12
6
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.4
8.5
87
447
FGB10
NOMESCO Finland
Repair of Ebstein's anomaly with mobilisation and ventricular plication
+∞
8.4
8
*
Q20.40
ICD-10 Finland
Double inlet left ventricle
+∞
8.4
8
*
AEX
HP
Other pulmonary or pulmonary artery valve procedure
+∞
8.4
8
*
Q21.3
ICD-10 Finland
Tetralogy of Fallot
+∞
8.4
8
*
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
+∞
8.4
8
*
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
+∞
8.4
8
*
Q21.0
ICD-10 Finland
Ventricular septal defect
+∞
8.4
8
*
74734
ICD-8 Finland
Other congenital anomalies of circulatory system, Stenosis, hypoplasia sive aplasia arteriae pulmonalis
+∞
8.4
8
*
7461A
ICD-9 Finland
Other congenital anomalies of heart, Tricuspid atresia and stenosis, congenital[VITIUM VALVULAE TRICUSPIDALIS CONGENITUM CUM ATRESI]
+∞
8.4
8
*
Q26.1
ICD-10 Finland
Persistent left superior vena cava
+∞
8.4
8
*
C07AB07
ATC
bisoprolol; oral
2.6
8.3
70
327
B01AB05
ATC
enoxaparin; parenteral
2.9
8.3
54
217
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
34.4
8.1
10
*
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
34.4
8.1
10
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.6
8.1
66
301
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.6
8.0
36
111
WX704
NOMESCO Finland
Intubation
4.6
7.8
26
61
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
46.3
7.8
9
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
19.0
7.7
11
6
I47.2
ICD-10 Finland
Ventricular tachycardia
12.3
7.7
13
11
74642
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium secundum
82.1
7.4
8
*
WX402
NOMESCO Finland
General anaesthesia
2.4
7.4
69
336
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
+∞
7.3
7
*
Q24.0
ICD-10 Finland
Dextrocardia
+∞
7.3
7
*
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
+∞
7.3
7
*
7452A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[TETRALOGIA FALLOT]
+∞
7.3
7
*
74654
ICD-8 Finland
Congenital anomalies of heart, Maleformatio valvulae tricuspidalis (morbus Ebstein incluso)
+∞
7.3
7
*
Q20.5
ICD-10 Finland
Discordant atrioventricular connection
+∞
7.3
7
*
Q22.8
ICD-10 Finland
Other congenital malformations of tricuspid valve
+∞
7.3
7
*
FHE30
NOMESCO Finland
Repair of tetralogy of Fallot with transannular patch
+∞
7.3
7
*
Q20.8
ICD-10 Finland
Other congenital malformations of cardiac chambers and connections
+∞
7.3
7
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.8
7.3
48
192
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
12.5
7.1
12
10
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
41.1
6.8
8
*
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
41.1
6.8
8
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
6.7
51
223
WX002
NOMESCO Finland
Sedation and analgesia
2.6
6.6
48
206
FM1CD
NOMESCO Finland
Very extensive CT of heart
71.4
6.4
7
*
I49.5
ICD-10 Finland
Sick sinus syndrome
14.7
6.4
10
7
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
+∞
6.3
6
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
+∞
6.3
6
*
5504
FHL
Subclavian pulmonary anastomosis (Blalock)
+∞
6.3
6
*
7451B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[DOUBLE OUTLET RIGHT VENTRICLE]
+∞
6.3
6
*
Q21.31
ICD-10 Finland
Tetralogy of Fallot and double outlet right ventricle
+∞
6.3
6
*
7460B
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITUM CUM ATRESIA]
+∞
6.3
6
*
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
6.3
6
*
5253
FHL
Cardiac lung machine
+∞
6.3
6
*
74629
ICD-8 Finland
Congenital anomalies of heart, Tetralogy of Fallot
+∞
6.3
6
*
Q23.4
ICD-10 Finland
Hypoplastic left heart syndrome
+∞
6.3
6
*
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
+∞
6.3
6
*
FBJ00
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery
+∞
6.3
6
*
7462A
ICD-9 Finland
Other congenital anomalies of heart, Ebstein's anomaly[ANOMALIA EBSTEIN]
+∞
6.3
6
*
Q21.18
ICD-10 Finland
Other spedified atrial septal defect
+∞
6.3
6
*
Q24.9
ICD-10 Finland
Congenital malformation of heart, unspecified
+∞
6.3
6
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
5.1
6.2
18
37
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
12.9
6.1
10
8
R07.4
ICD-10 Finland
Chest pain, unspecified
2.4
6.1
52
240
I50.9
ICD-10 Finland
Heart failure, unspecified
5.0
6.0
18
38
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
123
68
31.56
163.69
6.5
5.4
155.5
130.5
ng/l
0.20
117
60
187
281
18.15
138.78
9.1
4.4
673.8
741.0
ng/l
0.21
182
229
123
286
6.90
55.25
9.2
6.5
32.4
30.4
s
1.32
123
281
41
32
14.85
43.53
3.2
8.1
78.8
98.7
%
2.56
41
32
104
268
5.59
40.25
7.3
2.8
2042.5
592.2
ng/l
1.48
88
150
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
40
38
12.12
37.52
25.4
21.8
0.3
0.3
u/ml
0.50
30
24
131
436
4.78
36.64
3.6
3.1
—
—
—
0
0
35
45
8.75
26.13
1.5
1.5
—
—
—
0
0
40
64
7.13
24.73
23.2
18.8
24.8
24.3
mmol/l
0.42
40
64
166
852
3.34
21.65
4.6
4.5
—
—
—
0
0
45
94
5.52
21.19
2.0
2.6
32.2
7.3
ug/l
2.10
39
83
99
410
3.19
17.93
5.5
3.7
1.4
1.1
mg/l
0.50
75
301
48
134
4.12
15.72
20.8
14.8
1.1
0.9
mmol/l
0.10
42
111
70
258
3.29
15.13
4.8
2.9
23.3
23.8
%
0.10
64
234
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
18
21
9.09
14.29
1.4
2.0
116.3
99.3
%
0.66
18
21
36
88
4.55
13.95
25.8
14.6
0.7
0.7
%
0.21
36
88
36
88
4.55
13.95
25.8
14.6
1.1
1.4
%
2.20
36
88
16
17
9.92
13.56
1.5
2.1
148.4
114.2
%
1.24
16
17
150
874
2.55
13.23
11.1
7.3
18.2
20.2
umol/l
0.38
143
818
70
278
3.03
13.19
4.8
2.8
2.5
2.5
g/l
0.23
70
260
16
6
28.14
12.18
2.4
11.5
—
—
—
0
0
25
55
4.89
10.95
2.8
1.6
1.1
1.3
g/l
0.43
20
50
91
469
2.40
9.91
4.2
3.2
51.5
21.0
ng/l
0.88
54
237
102
553
2.33
9.89
3.5
3.2
3.2
2.7
mg/l
0.63
93
480
78
384
2.43
9.34
20.2
16.0
25.4
24.7
mmol/l
1.26
78
384
257
2110
3.76
9.18
28.0
13.1
139.3
139.5
mmol/l
1.05
257
2043
257
2111
3.76
9.16
28.3
13.1
4.0
3.9
mmol/l
1.40
257
2037
11
13
8.77
8.52
1.4
1.1
86.0
101.5
%
0.72
11
13
60
274
2.52
8.37
2.7
2.0
—
—
—
0
0
11
5
22.81
8.08
1.5
1.6
—
—
—
0
0
69
348
2.31
7.68
17.1
10.5
2.0
0.8
mmol/l
3.52
58
258
170
1207
2.05
7.66
13.2
7.0
5.9
6.2
mmol/l
2.17
164
1109
69
352
2.28
7.46
17.3
10.4
5.2
5.0
kpa
1.40
69
333
46
197
2.60
7.28
2.7
1.9
—
—
—
0
0
46
198
2.58
7.21
2.8
2.0
—
—
—
0
0
139
947
1.93
6.75
22.4
11.8
1.2
1.2
mmol/l
3.18
134
895
24
74
3.45
6.73
2.0
2.2
—
—
—
0
0
147
1022
1.93
6.70
18.6
11.2
1.2
1.2
mmol/l
1.86
137
915
251
2126
2.80
6.63
30.5
15.6
13.6
13.3
%
2.96
251
2095
20
57
3.70
6.28
11.5
12.1
22.3
23.6
mmol/l
1.31
20
50
68
369
2.11
6.22
10.0
10.6
1.7
1.1
mmol/l
1.34
62
287
199
1556
1.97
6.11
16.0
8.7
98.2
96.3
ml/min/173m2
0.44
161
1163
52
258
2.25
5.93
6.2
6.4
8.4
8.1
umol/l
0.05
47
208
23
75
3.25
5.92
2.0
2.5
—
—
—
0
0
9
7
13.23
5.62
1.1
1.9
12.2
11.7
umol/l
—
9
7
17
47
3.79
5.57
1.6
2.0
—
—
—
0
0
19
60
3.33
5.14
1.3
1.7
—
—
—
0
0
19
60
3.33
5.14
1.8
2.0
—
—
—
0
0
181
1413
1.80
5.11
11.4
11.6
3.8
3.7
e9/l
0.32
166
1202
145
1086
1.70
4.53
4.3
3.1
80.0
67.2
ug/l
0.62
139
1018
16
50
3.33
4.41
1.9
2.0
—
—
—
0
0
14
40
3.63
4.39
1.3
1.1
—
—
—
0
0
255
2281
2.37
4.14
23.1
11.7
25.1
21.3
mg/l
1.17
215
1626
15
48
3.25
3.99
2.0
4.9
—
—
—
0
0
256
2306
2.34
3.87
31.3
14.1
39.5
40.0
%
0.53
231
1981
86
592
1.65
3.52
3.8
3.0
2.4
2.4
mmol/l
0.15
80
538
12
36
3.44
3.52
4.7
4.2
57.4
52.7
%
0.46
12
36
25
114
2.31
3.47
2.6
2.0
—
—
—
0
0
12
37
3.34
3.38
1.5
1.5
—
—
—
0
0
26
123
2.23
3.32
1.3
1.9
—
—
—
0
0
11
33
3.43
3.22
1.5
1.3
—
—
—
0
0
13
44
3.05
3.18
1.3
1.2
3.9
2.9
u/ml
—
7
20
59
865
0.60
3.10
1.5
1.7
0.8
2.7
u/ml
2.03
17
158
9
21
4.39
3.02
1.8
1.2
—
—
—
0
0
100
737
1.56
3.02
4.4
4.2
—
—
—
0
0
15
57
2.72
3.01
10.8
14.9
—
2738.2
—
0
9
11
36
3.14
2.84
5.0
4.1
4.2
3.5
e9/l
0.42
11
36
20
94
2.21
2.62
2.1
1.7
—
—
—
0
0
85
623
1.52
2.57
4.2
4.0
0.5
0.3
e6/l
0.52
70
463
9
26
3.54
2.50
1.6
1.6
—
—
—
0
0
9
26
3.54
2.50
1.2
1.3
—
—
—
0
0
246
2256
1.76
2.46
13.4
9.0
25.2
26.3
u/l
0.55
241
2171
12
46
2.68
2.39
1.9
4.6
13.1
27.4
%
3.23
12
46
8
23
3.55
2.28
1.6
1.5
—
—
—
0
0
7
18
3.96
2.26
1.4
1.5
—
—
—
0
0
25
136
1.92
2.26
1.6
1.8
—
—
—
0
0
6
15
4.06
2.05
9.2
8.8
—
—
—
0
0
55
385
1.53
2.03
2.7
3.7
4.2
2.3
e6/l
0.57
36
223
22
123
1.86
1.86
2.8
2.9
—
—
—
0
0
5
12
4.22
1.83
1.8
1.2
—
—
—
0
0
31
195
1.66
1.78
1.6
1.7
1067.7
1224.6
nmol/l
0.51
25
148
13
63
2.12
1.62
2.1
2.0
—
—
—
0
0
6
20
3.04
1.59
1.2
1.8
—
—
—
0
0
6
20
3.04
1.59
6.7
11.2
—
—
—
0
0
6
20
3.04
1.59
1.2
1.8
—
—
—
0
0
6
20
3.04
1.59
1.2
1.8
—
—
—
0
0
37
253
1.53
1.53
1.4
1.7
489.4
29778262.8
pmol/l
0.50
31
225
196
2120
0.75
1.39
4.4
3.9
—
—
—
0
0
5
17
2.97
1.36
6.4
7.1
—
—
—
0
0
5
17
2.97
1.36
8.4
7.1
—
—
—
0
0
29
195
1.54
1.31
2.1
2.4
32.6
33.6
u/l
0.05
24
159
5
18
2.81
1.29
2.8
7.5
22.9
20.1
ug/l
—
5
18
8
38
2.14
1.19
3.4
2.0
—
—
—
0
0
20
128
1.61
1.12
3.0
2.0
167.6
155.2
u/ml
0.09
15
59
186
1705
1.27
1.10
4.7
3.8
15.2
14.5
pmol/l
3.23
170
1572
11
59
1.90
1.09
2.3
1.9
—
—
—
0
0
11
60
1.87
1.04
3.1
1.7
—
—
—
0
0
50
391
1.34
1.04
2.9
3.7
1.3
0.7
e6/l
0.63
32
230
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
29
0.00
0.98
0.0
1.4
—
—
—
0
0
0
30
0.00
0.98
0.0
1.4
—
—
—
0
0
168
1534
1.24
0.97
4.2
4.2
36.0
37.9
mmol/mol
2.40
159
1445
0
31
0.00
0.97
0.0
1.5
—
115.0
—
0
6
10
55
1.85
0.93
1.2
1.6
—
—
—
0
0
6
28
2.17
0.92
1.2
1.1
—
—
—
0
0
7
128
0.54
0.90
1.6
2.0
—
—
—
0
0
6
30
2.02
0.87
1.2
1.3
—
—
—
0
0
32
240
1.38
0.87
2.3
2.3
2.4
2.4
mmol/l
0.22
26
204
19
131
1.48
0.81
2.9
2.0
—
—
—
0
0
0
27
0.00
0.78
0.0
1.1
—
—
—
0
0
18
254
0.69
0.77
1.2
1.1
—
—
—
0
0
8
136
0.58
0.75
1.0
1.4
—
—
—
0
0
210
1989
1.23
0.74
5.3
4.2
2.1
1.9
mu/l
1.69
200
1852
10
157
0.62
0.71
1.2
1.4
—
—
—
0
0
7
42
1.68
0.69
1.7
1.9
—
—
—
0
0
7
42
1.68
0.69
2.4
4.0
23.4
5.1
u/ml
—
7
37
5
27
1.87
0.69
4.4
6.1
—
—
—
0
0
48
574
0.80
0.68
1.9
2.4
—
—
—
0
0
44
531
0.80
0.68
1.8
2.2
—
—
—
0
0
11
72
1.55
0.60
1.3
1.2
—
—
—
0
0
11
72
1.55
0.60
1.1
2.1
—
—
—
0
0
21
274
0.75
0.59
1.3
1.8
—
—
—
0
0
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
28
221
1.30
0.58
1.6
1.4
238.3
335.4
u/ml
0.32
28
206
8
54
1.50
0.58
1.6
1.7
—
—
—
0
0
11
74
1.51
0.54
1.5
1.5
—
—
—
0
0
11
74
1.51
0.54
1.5
1.5
—
—
—
0
0
15
203
0.72
0.54
1.4
1.4
—
—
—
0
0
10
66
1.53
0.53
1.1
2.3
—
—
—
0
0
163
1538
1.14
0.49
6.2
4.2
8.6
8.7
mm/h
0.06
158
1423
182
1733
1.14
0.47
3.8
3.7
2.7
2.8
mmol/l
0.71
167
1609
10
141
0.70
0.46
1.2
1.8
—
—
—
0
0
11
78
1.43
0.43
11.1
5.7
47.2
51.6
%
0.25
11
78
5
31
1.62
0.43
1.0
2.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
13.1
—
0
16
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
35
298
1.20
0.41
3.5
2.8
357.7
346.5
nmol/l
0.13
30
284
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
97
901
1.12
0.36
4.1
3.0
71.3
71.7
nmol/l
0.05
92
829
6
42
1.44
0.36
2.0
1.5
12.4
15.0
u/l
—
6
34
6
86
0.69
0.33
1.0
1.0
2.7
3.1
kpa
—
6
75
6
87
0.68
0.33
1.0
1.0
7.7
7.3
kpa
—
6
76
13
101
1.30
0.32
1.5
1.3
—
—
—
0
0
180
1735
1.11
0.32
3.7
3.5
4.3
4.6
mmol/l
2.54
171
1625
24
203
1.20
0.31
1.3
1.2
106.3
147.3
iu/ml
—
10
67
171
1647
1.10
0.30
3.6
3.2
1.2
1.2
mmol/l
0.01
159
1529
67
726
0.90
0.29
3.8
3.2
—
—
—
0
0
12
151
0.79
0.29
1.3
1.2
—
—
—
0
0
14
172
0.80
0.28
2.1
1.2
—
—
—
0
0
8
63
1.28
0.28
2.8
1.7
—
—
—
0
0
15
179
0.83
0.24
1.1
1.3
23.9
2.9
u/ml
—
10
116
32
355
0.89
0.21
4.1
4.1
28.0
13.6
mg/mmol
0.50
19
242
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
5.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
1416.0
—
0
12
0
12
0.00
0.21
0.0
1.0
—
7.8
—
0
6
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
4.7
—
86.9
—
0
14
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
173
1686
1.07
0.19
2.8
3.2
5.4
5.6
mmol/l
1.39
164
1549
176
1718
1.07
0.18
3.7
3.4
1.3
1.4
mmol/l
2.25
164
1596
8
70
1.15
0.16
1.4
2.4
37.8
40.6
u/l
—
8
64
28
307
0.90
0.16
1.2
1.3
4.1
8.2
u/ml
—
8
113
6
76
0.78
0.16
1.0
1.1
—
—
—
0
0
6
77
0.77
0.16
1.7
1.8
1.9
0.5
nmol/l
—
6
66
6
79
0.75
0.15
1.0
1.1
—
—
—
0
0
15
170
0.88
0.14
2.9
3.5
33.3
31.7
%
—
9
117
15
167
0.89
0.11
3.8
2.0
13.2
13.3
iu/l
0.00
15
121
5
45
1.11
0.10
3.2
2.3
0.2
0.1
nmol/l
—
5
33
10
114
0.87
0.09
1.5
1.6
—
—
—
0
0
57
549
1.05
0.08
1.8
1.6
84.3
98.5
pmol/l
1.66
33
274
101
986
1.04
0.08
3.6
3.4
0.0
0.0
estimate
0.00
23
170
52
501
1.05
0.08
4.5
3.5
0.0
0.0
estimate
0.50
23
175
7
82
0.85
0.07
1.3
1.4
—
—
—
0
0
9
88
1.02
0.07
1.4
1.4
—
—
—
0
0
8
92
0.87
0.07
1.3
1.2
—
—
—
0
0
8
94
0.85
0.07
2.0
1.6
—
—
—
0
0
87
886
0.97
0.05
1.8
1.9
—
—
—
0
0
14
130
1.08
0.04
1.3
1.5
—
—
—
0
0
32
331
0.96
0.04
1.4
2.0
—
—
—
0
0
37
359
1.04
0.03
1.4
1.4
—
—
—
0
0
100
989
1.02
0.02
4.8
4.9
0.0
0.0
estimate
0.00
24
180
14
148
0.94
0.02
6.1
5.4
—
—
—
0
0
12
113
1.06
0.02
2.1
2.5
0.4
0.8
ug/l
—
5
61
12
118
1.02
0.00
1.3
1.4
—
—
—
0
0
12
118
1.02
0.00
1.3
1.4
—
—
—
0
0
12
118
1.02
0.00
1.3
1.4
—
—
—
0
0
12
118
1.02
0.00
1.3
1.4
—
—
—
0
0
32
317
1.01
0.00
1.3
1.2
15.7
27.6
iu/ml
—
10
83
23
233
0.99
0.00
1.3
1.5
—
—
—
0
0
100
995
1.01
0.00
3.7
3.4
0.0
0.0
estimate
0.00
24
172
134
1345
0.99
0.00
4.9
3.8
51.2
35.4
u/l
1.96
128
1295
0
7
0.00
0.00
0.0
4.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
13
130
1.00
0.00
1.3
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
0.00
0.0
6.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
6.0
—
4.1
—
0
7
5
54
0.92
0.00
1.2
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
1.7
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES | 3.441 [2.43, 4.87] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.268 |
During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 1682 females with Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES | 4.147 [3.13, 5.5] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 1349 males with Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.287% | 0.541% |
| 5 | 2.239% | 5.113% |
| 10 | 5.248% | 12.434% |
| 15 | 9.974% | 22.743% |
| 20 | 16.615% | 36.333% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES – Congenital malformations of pulmonary and tricuspid valves
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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