No definition available.
Congenital malformations of pulmonary and tricuspid valves
Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
279 |
4. Check minimum number of eventsNone |
279 |
5. Include endpointsNone |
279 |
6. Filter based on genotype QC (FinnGen only) |
258 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_CIRCULATO_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q2
- Name in latin
- Malformationes congenitae valvae (trunci) pulmonalis et valvae tricuspidalis
Similar endpoints
↥List of similar endpoints to
Congenital malformations of pulmonary and tricuspid valves
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations of the circulatory system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Congenital malformations, deformations and chromosomal abnormalities
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3353 | 1847 | 1493 |
| Only index persons | 2303 | 1282 | 1021 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 1.11 | 1.00 | 0.99 |
| Only index persons | 6.33 | 6.78 | 5.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 258 | 152 | 106 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 11.08 | 15.26 | 5.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 279
- Matched controls
- 2790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
204.1
170
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
100.2
185.2
98
15
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
53.6
184.5
113
35
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
23.4
157.2
147
127
201
Kela drug reimbursment
Chronic cardiac insufficiency
58.9
128.1
74
17
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
15.2
122.7
173
270
XF404
NOMESCO Finland
Ambulatory ECG
23.1
121.7
101
67
XF400
NOMESCO Finland
ECG with 12 standard connections
13.8
110.2
147
209
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
67.8
105.9
59
11
XF402
NOMESCO Finland
ECG with work load test
21.4
101.8
85
56
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
46.5
92.5
56
15
C03DA01
ATC
spironolactone; oral
17.7
89.4
82
64
B01AA03
ATC
warfarin; systemic
16.5
86.4
83
70
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
14.1
82.3
88
88
C03CA01
ATC
furosemide; systemic
11.1
79.4
107
148
FM2CE, ,
NOMESCO Finland
18.0
76.9
68
49
TPH07
NOMESCO Finland
Cathetrisation of artery
11.9
74.4
90
107
C01AA05
ATC
digoxin; systemic
32.2
68.7
46
17
GD1AA
NOMESCO Finland
Thorax X-ray examination
7.1
59.0
179
562
ZXE20
NOMESCO Finland
More than three and less than five hours
8.3
57.9
97
169
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.9
57.4
103
193
Q21.10
ICD-10 Finland
Persistent ostium secundum
+∞
57.3
53
*
Q22.5
ICD-10 Finland
Ebstein anomaly
+∞
52.8
49
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
23.7
52.3
39
19
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
+∞
48.4
45
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
10.0
46.2
59
73
31
HP
Congenital heart failure surgery
+∞
46.1
43
*
I37.0
ICD-10 Finland
Pulmonary valve stenosis
+∞
46.1
43
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
502.0
44.5
43
*
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
+∞
43.9
41
*
Z2221
NOMESCO Finland
Medical doctor
5.4
43.8
150
495
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
9.2
43.8
60
81
ZXD10
NOMESCO Finland
Scheduled procedure
5.5
43.8
172
635
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
+∞
41.7
39
*
WX408
NOMESCO Finland
General anesthesy, balanced
5.2
41.1
140
456
61
HP
Catheterization and pressure measurement of the left side of the heart
447.2
40.2
39
*
TFP20
NOMESCO Finland
Cardiodefibrillation
15.7
39.8
36
26
Q22.0
ICD-10 Finland
Pulmonary valve atresia
+∞
39.5
37
*
XF600
NOMESCO Finland
Bloodpressure measurement
7.1
38.9
69
124
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
119.7
38.9
41
*
ZXE10
NOMESCO Finland
More than one and less than three hours
4.7
36.2
146
532
62
HP
Catheterization and pressure measurement of the right side of the heart
381.2
34.7
34
*
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
+∞
31.9
30
*
WX892
NOMESCO Finland
Monitored bed care
6.8
30.8
54
95
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
173.6
30.3
31
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
7.0
29.2
49
82
WX882
NOMESCO Finland
High dependency care
6.1
29.0
57
112
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
6.0
28.7
58
117
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.2
28.7
110
375
Z98.8
ICD-10 Finland
Other specified postsurgical states
111.6
28.3
30
*
Q20.48
ICD-10 Finland
Single ventricle
+∞
27.6
26
*
R4110
NOMESCO Finland
Physiotherapy
3.9
27.4
123
466
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
7.2
25.6
41
65
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
64.4
25.5
29
5
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
43.3
25.5
31
8
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
25.4
24
*
WX872
NOMESCO Finland
Intensive care
22.6
23.7
34
17
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
+∞
23.2
22
*
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
130.8
23.0
24
*
Q22.2
ICD-10 Finland
Congenital pulmonary valve insufficiency
+∞
22.2
21
*
Q21.30
ICD-10 Finland
Tetralogy of Fallot
+∞
22.2
21
*
Z3231
NOMESCO Finland
Registered nurse
3.3
21.7
139
641
207
Kela drug reimbursment
Chronic arrhythmias
6.5
21.7
38
66
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
19.9
21.4
32
18
XFE00
NOMESCO Finland
Epicardial ultrasonography
40.7
21.2
26
7
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
+∞
21.1
20
*
XF622
NOMESCO Finland
Measurement of minute volume of heart
226.2
20.9
21
*
74663
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae pulmonalis
+∞
20.0
19
*
7460C
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITA CUM STENOSIS]
+∞
20.0
19
*
Q21.19
ICD-10 Finland
Atrial septal defect NOS
+∞
20.0
19
*
ZXD05
NOMESCO Finland
Urgent procedure
3.2
19.3
113
488
ZXE00
NOMESCO Finland
One hour or less
3.1
19.0
150
766
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
+∞
19.0
18
*
Q25.0
ICD-10 Finland
Patent ductus arteriosus
+∞
19.0
18
*
Q22.41
ICD-10 Finland
Tricuspid atresia
+∞
19.0
18
*
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
17.9
17
*
Q20.1
ICD-10 Finland
Double outlet right ventricle
+∞
17.9
17
*
Q87.14
ICD-10 Finland
Noonan's syndrome
191.7
17.7
18
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
8.1
17.2
24
32
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
37.7
16.9
21
6
I37.2
ICD-10 Finland
Pulmonary valve stenosis with insufficiency
+∞
16.8
16
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.4
16.4
74
270
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.4
16.3
72
259
I44.2
ICD-10 Finland
Atrioventricular block, complete
26.4
16.3
22
9
G04BE03
ATC
sildenafil; oral
63.9
16.0
18
*
FJD20
NOMESCO Finland
Bypass of pulmonary valve with ventriculopulmonary prosthesis or homograft
+∞
15.8
15
*
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
+∞
15.8
15
*
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
+∞
15.8
15
*
C01BD01
ATC
amiodarone; systemic
25.1
15.3
21
9
Z3226
NOMESCO Finland
Physiotherapist
3.0
15.2
90
383
FJF10
NOMESCO Finland
Replacement of pulmonary valve using biological prosthesis
+∞
14.7
14
*
Q21.32
ICD-10 Finland
Pulmonary atresia with Fallot ventricular septal defect
+∞
14.7
14
*
FJE42
NOMESCO Finland
Percutaneous transluminal expansion of pulmonary valve
+∞
14.7
14
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
10.9
13.8
26
26
ZX120
NOMESCO Finland
Intravenous
4.0
13.7
43
122
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
+∞
13.7
13
*
Q22.40
ICD-10 Finland
Congenital tricuspid stenosis
+∞
13.7
13
*
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
+∞
13.7
13
*
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
+∞
13.7
13
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
4.0
13.6
43
123
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
13.1
13.4
23
19
C07AA07
ATC
sotalol; systemic
17.8
13.2
20
12
B01AB05
ATC
enoxaparin; parenteral
3.1
13.0
67
261
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
52.6
13.0
15
*
XF620
NOMESCO Finland
Examination of circulation with color method
73.3
12.7
14
*
602
Kela drug reimbursment
Children's severe malnutrition
6.0
12.6
23
41
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
+∞
12.6
12
*
Q23.11
ICD-10 Finland
Bicuspid aortic valve
+∞
12.6
12
*
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
+∞
12.6
12
*
1EA01, ,
NOMESCO Finland
+∞
12.6
12
*
Q22.3
ICD-10 Finland
Other congenital malformations of pulmonary valve
+∞
12.6
12
*
WX402
NOMESCO Finland
General anaesthesia
2.7
12.3
88
409
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
15.6
12.0
19
13
C07AB07
ATC
bisoprolol; oral
2.6
11.6
88
419
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
+∞
11.5
11
*
FFC00
NOMESCO Finland
Suture of ostium secundum type ASD
+∞
11.5
11
*
Q25.1
ICD-10 Finland
Coarctation of aorta
+∞
11.5
11
*
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
+∞
11.5
11
*
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
+∞
11.5
11
*
7AX01, ,
NOMESCO Finland
36.7
11.4
14
*
I50.9
ICD-10 Finland
Heart failure, unspecified
5.6
10.8
21
40
FM1BD
NOMESCO Finland
Extensive CT of heart
62.4
10.7
12
*
WX002
NOMESCO Finland
Sedation and analgesia
3.0
10.6
53
202
R07.4
ICD-10 Finland
Chest pain, unspecified
2.7
10.6
67
290
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
4.3
10.5
28
70
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
114.1
10.5
11
*
74642
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium secundum
+∞
10.5
10
*
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
10.5
10
*
7455A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ostium secundum type atrial septal defect
+∞
10.5
10
*
Q22.6
ICD-10 Finland
Hypoplastic right heart syndrome
+∞
10.5
10
*
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
+∞
10.5
10
*
WX704
NOMESCO Finland
Intubation
4.3
10.3
28
71
RS224, ,
NOMESCO Finland
13.8
10.3
17
13
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.4
10.2
101
540
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.9
9.6
49
188
ZX199
NOMESCO Finland
Other rote
15.8
9.6
15
10
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
9.5
72
339
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
103.4
9.5
10
*
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
103.4
9.5
10
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
5.2
9.5
20
41
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
+∞
9.4
9
*
7461A
ICD-9 Finland
Other congenital anomalies of heart, Tricuspid atresia and stenosis, congenital[VITIUM VALVULAE TRICUSPIDALIS CONGENITUM CUM ATRESI]
+∞
9.4
9
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
9.4
9
*
Q21.21
ICD-10 Finland
Atrioventricular duct
+∞
9.4
9
*
Q21.3
ICD-10 Finland
Tetralogy of Fallot
+∞
9.4
9
*
FGB10
NOMESCO Finland
Repair of Ebstein's anomaly with mobilisation and ventricular plication
+∞
9.4
9
*
Q20.40
ICD-10 Finland
Double inlet left ventricle
+∞
9.4
9
*
Q26.1
ICD-10 Finland
Persistent left superior vena cava
+∞
9.4
9
*
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
+∞
9.4
9
*
Q21.0
ICD-10 Finland
Ventricular septal defect
+∞
9.4
9
*
AEX
HP
Other pulmonary or pulmonary artery valve procedure
+∞
9.4
9
*
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
11.2
8.9
16
15
WZC30
NOMESCO Finland
Teaching
2.9
8.9
46
178
Z2446
NOMESCO Finland
Social worker
2.7
8.7
53
223
I47.1
ICD-10 Finland
Supraventricular tachycardia
4.8
8.7
20
44
EBA15
NOMESCO Finland
Extraction of multiple teeth
5.1
8.5
18
37
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
92.7
8.5
9
*
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
+∞
8.4
8
*
74654
ICD-8 Finland
Congenital anomalies of heart, Maleformatio valvulae tricuspidalis (morbus Ebstein incluso)
+∞
8.4
8
*
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
+∞
8.4
8
*
7460B
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITUM CUM ATRESIA]
+∞
8.4
8
*
Q20.8
ICD-10 Finland
Other congenital malformations of cardiac chambers and connections
+∞
8.4
8
*
74734
ICD-8 Finland
Other congenital anomalies of circulatory system, Stenosis, hypoplasia sive aplasia arteriae pulmonalis
+∞
8.4
8
*
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
+∞
8.4
8
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.4
8.2
31
99
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
17.8
8.1
12
7
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
22.8
8.1
11
5
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
13.6
8.0
13
10
K84
ICPC
Heart disease other
11.3
7.9
14
13
I47.2
ICD-10 Finland
Ventricular tachycardia
11.3
7.9
14
13
XQ903
NOMESCO Finland
Production of other scan or drawing
46.3
7.8
9
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.3
7.7
20
49
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
82.2
7.5
8
*
I50.0
ICD-10 Finland
Congestive heart failure
8.7
7.4
15
18
Q24.0
ICD-10 Finland
Dextrocardia
+∞
7.3
7
*
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
+∞
7.3
7
*
FHE30
NOMESCO Finland
Repair of tetralogy of Fallot with transannular patch
+∞
7.3
7
*
Q20.5
ICD-10 Finland
Discordant atrioventricular connection
+∞
7.3
7
*
Q24.9
ICD-10 Finland
Congenital malformation of heart, unspecified
+∞
7.3
7
*
7452A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[TETRALOGIA FALLOT]
+∞
7.3
7
*
Q22.8
ICD-10 Finland
Other congenital malformations of tricuspid valve
+∞
7.3
7
*
I50.1
ICD-10 Finland
Left ventricular failure
16.3
7.3
11
7
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
16.3
7.3
11
7
C09AA02
ATC
enalapril; systemic
3.2
7.2
30
102
B34.9
ICD-10 Finland
Viral infection, unspecified
3.4
7.2
27
86
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
12.5
7.1
12
10
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
3.1
7.1
30
103
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
4.6
7.1
17
39
ZX108
NOMESCO Finland
Inhalation
14.2
6.9
11
8
Z94.1
ICD-10 Finland
Heart transplant status
17.2
6.8
10
6
XX3BT
NOMESCO Finland
Other labeling with X-ray guidance
8.1
6.7
14
18
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
6.7
56
273
I49.5
ICD-10 Finland
Sick sinus syndrome
10.4
6.6
12
12
1CX08, ,
NOMESCO Finland
71.4
6.5
7
*
FM1CD
NOMESCO Finland
Very extensive CT of heart
71.4
6.5
7
*
R62.0
ICD-10 Finland
Delayed milestone
3.3
6.3
24
77
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
6.3
58
294
7451B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[DOUBLE OUTLET RIGHT VENTRICLE]
+∞
6.3
6
*
FBA96
NOMESCO Finland
Other suture or repair of pulmonary artery
+∞
6.3
6
*
FBJ00
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery
+∞
6.3
6
*
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
6.3
6
*
5253
FHL
Cardiac lung machine
+∞
6.3
6
*
5239
FHL
Other measure in this category
+∞
6.3
6
*
I27.0
ICD-10 Finland
Primary pulmonary hypertension
+∞
6.3
6
*
Q23.4
ICD-10 Finland
Hypoplastic left heart syndrome
+∞
6.3
6
*
Q22.4
ICD-10 Finland
Congenital tricuspid stenosis
+∞
6.3
6
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
+∞
6.3
6
*
FK1AC
NOMESCO Finland
Right cardioangiography
+∞
6.3
6
*
7462A
ICD-9 Finland
Other congenital anomalies of heart, Ebstein's anomaly[ANOMALIA EBSTEIN]
+∞
6.3
6
*
Q21.18
ICD-10 Finland
Other spedified atrial septal defect
+∞
6.3
6
*
Q21.31
ICD-10 Finland
Tetralogy of Fallot and double outlet right ventricle
+∞
6.3
6
*
5504
FHL
Subclavian pulmonary anastomosis (Blalock)
+∞
6.3
6
*
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
+∞
6.3
6
*
I44.1
ICD-10 Finland
Atrioventricular block, second degree
27.3
6.3
8
*
H01AC01
ATC
somatropin; parenteral
3.9
6.2
18
48
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.2
6.2
57
289
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
3.6
6.1
20
58
XF640, ,
NOMESCO Finland
8.9
6.1
12
14
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
123
68
31.56
163.69
6.5
5.4
155.46
130.47
ng/l
0.20
117
60
187
281
18.15
138.78
9.1
4.4
673.84
740.97
ng/l
0.21
182
229
123
286
6.90
55.25
9.2
6.5
32.35
30.44
s
1.32
123
281
168
596
5.57
45.27
20.6
8.7
1.62
1.15
inr
3.38
34
197
41
32
14.85
43.53
3.2
8.1
78.76
98.66
%
2.56
41
32
104
269
5.57
40.06
7.3
2.9
2042.55
590.53
ng/l
1.49
88
151
145
502
4.93
39.00
11.6
7.0
73.97
90.99
%
13.05
145
494
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
40
38
12.12
37.52
25.4
21.8
0.29
0.35
u/ml
0.50
30
24
131
436
4.78
36.64
3.6
3.1
—
—
—
0
0
35
45
8.75
26.13
1.5
1.5
—
—
—
0
0
40
64
7.13
24.73
23.2
18.8
24.75
24.25
mmol/l
0.42
40
64
166
854
3.33
21.52
3.9
3.1
—
—
—
0
0
45
94
5.52
21.19
2.0
2.6
32.21
7.28
ug/l
2.10
39
83
64
189
4.10
19.63
12.7
11.4
106.36
104.58
mmol/l
2.22
64
189
99
409
3.20
18.02
5.5
3.7
1.45
1.13
mg/l
0.50
75
301
48
135
4.09
15.56
20.8
14.7
1.10
0.97
mmol/l
0.08
42
112
70
258
3.29
15.13
4.8
2.9
23.29
23.82
%
0.10
64
234
36
88
4.55
13.95
25.8
14.6
0.68
0.71
%
0.21
36
88
36
88
4.55
13.95
25.7
14.6
1.07
1.42
%
2.20
36
88
150
873
2.55
13.28
11.1
7.3
18.14
20.23
umol/l
0.41
144
818
70
278
3.03
13.19
4.8
2.8
2.48
2.52
g/l
0.23
70
260
16
6
28.14
12.18
2.4
11.5
—
—
—
0
0
25
55
4.89
10.95
2.8
1.6
1.10
1.28
g/l
0.43
20
50
91
469
2.40
9.91
4.2
3.2
51.49
20.96
ng/l
0.88
54
238
102
553
2.33
9.89
3.5
3.2
3.21
2.72
mg/l
0.63
93
480
78
384
2.43
9.34
20.2
16.0
25.38
24.73
mmol/l
1.26
78
384
257
2109
3.77
9.21
28.0
13.1
139.31
139.53
mmol/l
1.05
257
2043
257
2110
3.76
9.18
28.3
13.1
3.99
3.94
mmol/l
1.39
257
2037
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
18
21
9.08
8.94
1.4
2.0
116.28
99.33
%
0.66
18
21
16
17
9.91
8.39
1.5
2.1
148.37
114.24
%
1.24
16
17
60
275
2.51
8.30
2.8
2.0
—
—
—
0
0
11
5
22.81
8.08
1.5
1.6
—
—
—
0
0
26
75
3.72
8.03
7.2
15.6
0.80
0.62
%
1.73
26
75
177
1268
2.08
7.87
9.1
9.0
27.18
33.89
%
11.66
169
1224
20
34
6.25
7.84
6.2
25.8
72.93
70.32
%
0.31
20
34
69
348
2.31
7.68
17.1
10.5
2.00
0.83
mmol/l
3.52
58
258
170
1207
2.05
7.66
13.2
7.0
5.92
6.24
mmol/l
2.18
164
1109
69
352
2.28
7.46
17.3
10.4
5.17
5.01
kpa
1.33
69
336
46
198
2.58
7.21
2.7
1.9
—
—
—
0
0
46
199
2.57
7.13
2.8
2.0
—
—
—
0
0
172
1245
1.99
7.12
9.2
8.9
58.30
51.25
%
11.48
164
1201
139
947
1.93
6.75
22.4
11.8
1.21
1.23
mmol/l
3.11
134
897
24
74
3.45
6.73
2.0
2.2
—
—
—
0
0
147
1022
1.93
6.70
18.6
11.2
1.22
1.23
mmol/l
1.81
137
918
68
369
2.11
6.22
10.0
10.6
1.31
1.07
mmol/l
0.33
63
289
252
2157
2.74
6.17
30.5
15.6
13.75
13.82
%
0.16
252
2129
199
1563
1.95
5.94
15.9
8.7
98.19
96.31
ml/min/173m2
0.42
161
1173
52
258
2.25
5.93
6.2
6.4
8.41
8.13
umol/l
0.05
47
208
23
75
3.25
5.92
2.0
2.5
—
—
—
0
0
9
7
13.23
5.62
1.1
1.9
12.22
11.73
umol/l
—
9
7
11
13
8.75
5.61
1.4
1.1
86.00
101.54
%
0.72
11
13
17
47
3.79
5.57
1.6
2.0
—
—
—
0
0
20
63
3.34
5.43
1.9
2.3
—
—
—
0
0
20
63
3.34
5.43
1.9
2.3
—
—
—
0
0
19
60
3.33
5.14
1.8
2.0
—
—
—
0
0
19
60
3.33
5.14
1.3
1.7
—
—
—
0
0
181
1412
1.80
5.14
11.4
11.6
3.83
3.72
e9/l
0.32
166
1202
145
1086
1.70
4.53
4.3
3.1
80.02
67.20
ug/l
0.62
139
1018
13
28
4.82
4.43
2.3
2.2
—
—
—
0
0
16
50
3.33
4.41
1.9
2.0
—
—
—
0
0
16
51
3.27
4.28
2.1
2.5
—
—
—
0
0
16
51
3.27
4.28
2.1
2.5
—
—
—
0
0
255
2281
2.37
4.14
23.1
11.7
25.15
21.34
mg/l
1.14
215
1626
15
48
3.25
3.99
2.0
4.9
—
—
—
0
0
14
40
3.63
3.66
1.3
1.1
—
—
—
0
0
86
592
1.65
3.52
3.8
3.0
2.38
2.38
mmol/l
0.16
80
541
25
114
2.31
3.47
2.6
2.0
—
—
—
0
0
26
123
2.23
3.32
1.3
1.9
—
—
—
0
0
13
44
3.05
3.18
1.3
1.2
3.86
2.90
u/ml
—
7
20
59
867
0.59
3.13
1.5
1.7
0.78
2.66
u/ml
2.03
17
158
12
36
3.44
3.06
4.7
4.2
57.42
52.72
%
0.46
12
36
9
21
4.39
3.02
1.8
1.2
—
—
—
0
0
100
737
1.56
3.02
4.4
4.2
—
—
—
0
0
15
57
2.72
3.01
10.8
14.9
—
2738.22
—
0
9
12
37
3.34
2.97
1.5
1.5
—
—
—
0
0
11
33
3.43
2.84
1.5
1.3
—
—
—
0
0
20
94
2.21
2.62
2.1
1.7
—
—
—
0
0
11
36
3.14
2.59
5.0
4.1
4.24
3.46
e9/l
0.42
11
36
85
623
1.52
2.57
4.2
4.0
0.48
0.29
e6/l
0.53
70
465
13
50
2.68
2.57
1.9
4.8
12.62
9.66
%
0.32
13
50
9
26
3.54
2.50
1.6
1.6
—
—
—
0
0
9
26
3.54
2.50
1.2
1.3
—
—
—
0
0
246
2255
1.77
2.47
13.4
9.0
25.23
26.34
u/l
0.55
241
2170
12
46
2.68
2.39
1.9
4.6
13.08
27.39
%
3.23
12
46
8
23
3.55
2.28
1.6
1.5
—
—
—
0
0
7
18
3.96
2.26
1.4
1.5
—
—
—
0
0
25
136
1.92
2.26
1.6
1.8
—
—
—
0
0
6
15
4.06
2.05
9.2
8.8
—
—
—
0
0
55
385
1.53
2.03
2.7
3.7
4.25
2.30
e6/l
0.57
36
223
7
22
3.24
1.89
2.3
1.6
8438.86
7131.35
e6/l
—
7
17
22
123
1.86
1.86
2.8
2.9
—
—
—
0
0
5
12
4.22
1.83
1.8
1.3
—
—
—
0
0
31
195
1.66
1.78
1.6
1.7
1067.68
1224.64
nmol/l
0.51
25
148
12
55
2.23
1.70
1.3
1.5
217.00
292.64
ug/g
—
7
28
13
63
2.12
1.62
2.1
2.0
—
—
—
0
0
6
20
3.04
1.59
1.2
1.8
—
—
—
0
0
6
20
3.04
1.59
6.7
11.2
—
—
—
0
0
6
20
3.04
1.59
1.2
1.8
—
—
—
0
0
6
20
3.04
1.59
1.2
1.8
—
—
—
0
0
37
253
1.53
1.53
1.4
1.7
489.35
29778262.83
pmol/l
0.50
31
225
196
2120
0.75
1.39
4.4
3.9
—
—
—
0
0
5
17
2.97
1.36
8.4
7.1
—
—
—
0
0
5
17
2.97
1.36
6.4
7.1
—
—
—
0
0
29
195
1.54
1.31
2.1
2.4
32.62
33.62
u/l
0.05
24
159
5
18
2.81
1.29
2.8
7.5
22.94
20.05
ug/l
—
5
18
12
63
1.95
1.24
2.9
4.4
32.92
40.22
umol/l
1.22
12
58
8
38
2.14
1.19
3.4
2.0
—
—
—
0
0
20
128
1.61
1.12
3.0
2.0
167.60
155.19
u/ml
0.09
15
59
186
1706
1.27
1.09
4.7
3.8
15.21
14.47
pmol/l
3.23
170
1573
11
59
1.90
1.09
2.3
1.9
—
—
—
0
0
11
60
1.87
1.04
3.1
1.7
—
—
—
0
0
50
391
1.34
1.04
2.9
3.7
1.32
0.71
e6/l
0.63
32
230
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
29
0.00
0.98
0.0
1.4
—
—
—
0
0
0
30
0.00
0.98
0.0
1.4
—
—
—
0
0
168
1534
1.24
0.97
4.2
4.2
35.99
37.92
mmol/mol
2.40
159
1446
0
31
0.00
0.97
0.0
1.5
—
115.00
—
0
6
10
55
1.85
0.93
1.2
1.6
—
—
—
0
0
6
28
2.17
0.92
1.2
1.1
—
—
—
0
0
7
128
0.54
0.90
1.6
2.0
—
—
—
0
0
6
30
2.02
0.87
1.2
1.3
—
—
—
0
0
32
242
1.36
0.83
2.3
2.2
2.42
2.43
mmol/l
0.21
26
206
19
131
1.48
0.81
2.9
2.0
—
—
—
0
0
0
27
0.00
0.78
0.0
1.1
—
—
—
0
0
18
254
0.69
0.77
1.2
1.1
—
—
—
0
0
210
1988
1.23
0.75
5.3
4.2
2.15
1.89
mu/l
1.67
200
1852
8
136
0.58
0.75
1.0
1.4
—
—
—
0
0
10
157
0.62
0.71
1.2
1.4
—
—
—
0
0
7
42
1.68
0.69
1.7
1.9
—
—
—
0
0
7
42
1.68
0.69
2.4
4.0
23.39
7.69
u/ml
—
7
42
5
27
1.87
0.69
4.4
6.1
—
—
—
0
0
48
573
0.80
0.67
1.9
2.4
—
—
—
0
0
44
530
0.80
0.67
1.8
2.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
211.88
—
0
20
11
72
1.55
0.60
1.1
2.1
—
—
—
0
0
11
72
1.55
0.60
1.3
1.2
—
—
—
0
0
21
274
0.75
0.59
1.3
1.8
—
—
—
0
0
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
28
221
1.30
0.58
1.6
1.4
238.25
335.42
u/ml
0.32
28
206
8
54
1.50
0.58
1.6
1.7
—
—
—
0
0
11
74
1.51
0.54
1.5
1.5
—
—
—
0
0
11
74
1.51
0.54
1.5
1.5
—
—
—
0
0
15
203
0.72
0.54
1.4
1.4
—
—
—
0
0
10
66
1.53
0.53
1.1
2.3
—
—
—
0
0
163
1538
1.14
0.49
6.2
4.2
8.55
8.71
mm/h
0.06
158
1424
182
1732
1.15
0.48
3.8
3.7
2.67
2.77
mmol/l
0.76
167
1613
10
141
0.70
0.46
1.2
1.8
—
—
—
0
0
11
78
1.43
0.43
11.1
5.7
47.15
51.58
%
0.25
11
78
5
31
1.62
0.43
1.0
2.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
13.13
—
0
16
35
298
1.20
0.41
3.5
2.8
357.70
346.49
nmol/l
0.13
30
284
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
97
900
1.12
0.36
4.1
3.0
71.30
71.69
nmol/l
0.06
92
828
6
42
1.44
0.36
2.0
1.5
12.40
15.00
u/l
—
6
34
6
86
0.69
0.33
1.0
1.0
2.70
3.12
kpa
—
6
75
6
87
0.68
0.33
1.0
1.0
7.73
7.34
kpa
—
6
76
180
1734
1.11
0.32
3.7
3.5
4.32
4.58
mmol/l
2.61
171
1627
13
101
1.30
0.32
1.5
1.3
—
—
—
0
0
24
203
1.20
0.31
1.3
1.2
106.30
147.30
iu/ml
—
10
67
171
1646
1.10
0.30
3.6
3.2
1.22
1.22
mmol/l
0.01
159
1529
67
726
0.90
0.29
3.8
3.2
—
—
—
0
0
12
151
0.79
0.29
1.2
1.2
—
—
—
0
0
14
172
0.80
0.28
2.1
1.2
—
—
—
0
0
8
63
1.28
0.28
2.8
1.6
—
—
—
0
0
15
179
0.83
0.24
1.1
1.3
23.90
3.50
u/ml
—
10
132
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
4.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
1416.00
—
0
12
0
12
0.00
0.21
0.0
1.0
—
7.85
—
0
6
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
3.2
—
26.77
—
0
13
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
32
354
0.89
0.21
3.8
4.0
27.98
13.56
mg/mmol
0.50
19
242
0
14
0.00
0.20
0.0
4.7
—
86.86
—
0
14
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
173
1685
1.07
0.19
2.8
3.2
5.43
5.61
mmol/l
1.40
164
1549
176
1717
1.07
0.18
3.7
3.4
1.34
1.43
mmol/l
2.30
164
1599
8
70
1.15
0.16
1.4
2.4
37.75
40.55
u/l
—
8
64
28
307
0.90
0.16
1.2
1.3
4.13
8.20
u/ml
—
8
113
6
76
0.78
0.16
1.0
1.1
—
—
—
0
0
6
77
0.77
0.16
1.7
1.8
1.95
0.52
nmol/l
—
6
66
6
79
0.75
0.15
1.0
1.1
—
—
—
0
0
15
169
0.88
0.13
2.9
3.5
33.80
31.62
%
—
10
117
15
167
0.89
0.11
3.8
2.0
13.19
13.29
iu/l
0.00
15
121
5
45
1.11
0.10
3.2
2.3
0.18
0.14
nmol/l
—
5
33
10
114
0.87
0.09
1.5
1.6
—
—
—
0
0
57
549
1.05
0.08
1.8
1.6
84.29
98.46
pmol/l
1.66
33
274
52
500
1.05
0.08
4.5
3.5
0.00
0.01
estimate
0.50
23
175
101
988
1.03
0.07
3.6
3.4
0.00
0.00
estimate
-0.00
25
180
7
82
0.85
0.07
1.3
1.4
—
—
—
0
0
9
88
1.02
0.07
1.4
1.4
—
—
—
0
0
8
92
0.87
0.07
1.3
1.2
—
—
—
0
0
8
94
0.85
0.07
2.0
1.6
—
—
—
0
0
22
232
0.94
0.05
1.3
1.5
—
—
—
0
0
87
886
0.97
0.05
1.8
1.9
—
—
—
0
0
14
130
1.08
0.04
1.3
1.5
—
—
—
0
0
32
331
0.96
0.04
1.4
2.0
—
—
—
0
0
37
359
1.04
0.03
1.4
1.4
—
—
—
0
0
100
987
1.02
0.03
4.8
4.9
0.00
0.00
estimate
-0.00
24
180
14
148
0.94
0.02
6.1
5.4
—
—
—
0
0
12
113
1.06
0.02
2.1
2.5
0.37
0.79
ug/l
—
5
61
100
993
1.01
0.01
3.7
3.4
0.00
0.00
estimate
-0.00
24
172
12
118
1.02
0.00
1.3
1.4
—
—
—
0
0
12
118
1.02
0.00
1.3
1.4
—
—
—
0
0
12
118
1.02
0.00
1.3
1.4
—
—
—
0
0
12
118
1.02
0.00
1.3
1.4
—
—
—
0
0
15
148
1.01
0.00
1.3
1.2
—
34.47
—
0
6
134
1344
0.99
0.00
4.9
3.8
51.17
35.40
u/l
1.96
128
1294
32
317
1.01
0.00
1.3
1.2
15.66
27.43
iu/ml
—
10
84
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
1.73
—
0
5
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.92
-0.00
1.2
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
6.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
93.37
—
0
7
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.0
—
4.14
—
0
7
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
13
130
1.00
-0.00
1.3
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES | 3.441 [2.43, 4.87] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.268 |
During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 1682 females with Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES | 4.147 [3.13, 5.5] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 1349 males with Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.287% | 0.541% |
| 5 | 2.239% | 5.113% |
| 10 | 5.248% | 12.434% |
| 15 | 9.974% | 22.743% |
| 20 | 16.615% | 36.333% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES – Congenital malformations of pulmonary and tricuspid valves
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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