No definition available.
Renal agenesis and other reduction defects of kidney
Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
178 |
4. Check minimum number of eventsNone |
178 |
5. Include endpointsNone |
178 |
6. Filter based on genotype QC (FinnGen only) |
165 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_URINARY_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q6[0-4]
- Name in latin
- Agenesis/aplasia/hypoplasia/atrophia renis/renum
Similar endpoints
↥List of similar endpoints to
Renal agenesis and other reduction defects of kidney
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the urinary system
- Congenital malformations of the urinary system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- All chronic kidney diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1672 | 714 | 949 |
| Only index persons | 1260 | 565 | 695 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.03 |
| Only index persons | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 14.59 | 17.97 | 11.61 |
| Only index persons | 24.56 | 26.79 | 22.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 165 | 71 | 94 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 44.19 | 36.89 | 49.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 178
- Matched controls
- 1780
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A11CC03
ATC
alfacalcidol; systemic
86.0
114.0
62
11
Q60.0
ICD-10 Finland
Renal agenesis, unilateral
+∞
112.9
96
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
40.1
105.9
71
29
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
73.0
93.5
52
10
N18.8
ICD-10 Finland
Other chronic renal failure
45.3
75.9
47
14
L04AA06
ATC
mycophenolic acid; systemic
52.8
74.2
44
11
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
120.8
65.8
68
9
Q60.3
ICD-10 Finland
Renal hypoplasia, unilateral
+∞
53.9
49
*
Z94.0
ICD-10 Finland
Kidney transplant status
236.2
52.0
51
*
A12AA04
ATC
calcium carbonate; oral
90.9
48.3
52
8
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
16.0
48.1
46
38
127
Kela drug reimbursment
Transplant complication
93.0
44.7
48
7
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
165.2
38.4
39
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
438.0
36.3
35
*
137
Kela drug reimbursment
Uraemia requiring dialysis
112.1
34.2
36
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
112.1
34.2
36
*
205
Kela drug reimbursment
Chronic hypertension
6.5
33.9
82
206
H02AB04
ATC
methylprednisolone; systemic
7.4
33.1
61
117
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.9
31.8
46
67
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
96.5
29.9
32
*
TK800
NOMESCO Finland
Hemodialysis
40.6
29.1
36
11
N18.0
ICD-10 Finland
End-stage renal disease
330.6
28.6
28
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.0
27.1
63
149
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
85.8
26.7
29
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
40.1
26.7
33
10
L04AD02
ATC
tacrolimus; systemic
105.5
25.4
27
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
57.3
25.2
29
6
B03XA02
ATC
darbepoetin alfa; parenteral
44.7
24.8
30
8
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
144.5
24.3
25
*
B05DA
ATC
Isotonic solutions
96.4
23.3
25
*
M04AA01
ATC
allopurinol; systemic
5.9
22.7
50
111
L04AD01
ATC
ciclosporin; systemic
26.5
22.6
31
14
C08CA02
ATC
felodipine; oral
8.0
22.6
34
51
C03CA01
ATC
furosemide; systemic
4.7
22.5
79
259
Q60.4
ICD-10 Finland
Renal hypoplasia, bilateral
+∞
22.4
21
*
Q60.2
ICD-10 Finland
Renal agenesis, unspecified
+∞
22.4
21
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
9.0
21.0
28
36
Z49.0
ICD-10 Finland
Preparatory care for dialysis
65.6
20.4
23
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.4
20.0
32
51
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
18.7
19.6
30
19
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
78.7
19.2
21
*
ZXE20
NOMESCO Finland
More than three and less than five hours
5.0
18.8
49
125
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
7.5
18.5
29
45
B05DB
ATC
Hypertonic solutions
59.1
18.4
21
*
196
Kela drug reimbursment
Paricalcitol and cinacalcet
199.0
17.9
18
*
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
199.0
17.9
18
*
Z49.2
ICD-10 Finland
Other dialysis
55.9
17.4
20
*
L04AA01
ATC
[U] ciclosporin
55.9
17.4
20
*
N26
ICD-10 Finland
Unspecified contracted kidney
+∞
16.9
16
*
N19
ICD-10 Finland
Unspecified kidney failure
14.9
16.8
28
22
C07AB02
ATC
metoprolol; systemic
4.5
16.3
49
139
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.8
16.3
43
110
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
+∞
14.8
14
*
H05BX01
ATC
cinacalcet; oral
162.8
14.7
15
*
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
46.7
14.4
17
*
C08CA01
ATC
amlodipine; oral
3.4
14.3
80
343
UKC02
NOMESCO Finland
Cystoscopy
4.3
14.1
43
122
TK820
NOMESCO Finland
Peritoneal dialysis
58.2
14.1
16
*
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
58.2
14.1
16
*
V03AE02
ATC
sevelamer; oral
81.2
13.8
15
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
151.0
13.6
14
*
R50.9
ICD-10 Finland
Fever, unspecified
3.7
13.5
55
192
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
43.7
13.4
16
*
C09AA02
ATC
enalapril; systemic
3.8
12.9
48
157
B03XA01
ATC
erythropoietin; parenteral
34.9
12.8
16
5
Q60.5
ICD-10 Finland
Renal hypoplasia, unspecified
+∞
12.6
12
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.1
12.5
85
404
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.8
12.1
30
72
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.7
11.6
45
151
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.1
11.5
21
38
V03AE01
ATC
polystyrene sulfonate; oral
37.7
11.4
14
*
Z2446
NOMESCO Finland
Social worker
4.2
11.3
34
95
M10.9
ICD-10 Finland
Gout, unspecified
5.1
11.1
25
55
C08CA05
ATC
nifedipine; systemic
6.1
11.0
20
36
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
63.9
10.8
12
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.0
10.5
65
287
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
10.5
69
315
7530A
ICD-9 Finland
Congenital anomalies of urinary system, Renal agenesis and dysgenesis[AGENESIA RENIS]
+∞
10.5
10
*
75301
ICD-8 Finland
Congenital anomalies of urinary system, Agenesis renis unilateralis
+∞
10.5
10
*
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
42.7
10.1
12
*
U14
ICPC
Kidney symptom/complaint
18.8
9.6
14
8
KBV00
NOMESCO Finland
Insertion of stent into ureter
105.4
9.5
10
*
V03AE03
ATC
lanthanum carbonate; oral
105.4
9.5
10
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.2
9.5
27
72
KC1JB
NOMESCO Finland
Miktiocystography with X-ray
+∞
9.5
9
*
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
+∞
9.5
9
*
RD210, ,
NOMESCO Finland
7.5
9.2
21
31
N18
ICD-10 Finland
Chronic kidney disease
38.8
9.1
11
*
3AC01, ,
NOMESCO Finland
38.8
9.1
11
*
L04AX01
ATC
azathioprine; systemic
7.9
9.0
20
28
C08CA13
ATC
lercanidipine; oral
3.6
8.9
32
101
A02BC01
ATC
omeprazole; systemic
2.8
8.8
55
242
XPX08
NOMESCO Finland
Intraoperative flow measurement
52.6
8.8
10
*
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
12.5
8.8
15
13
204
Kela drug reimbursment
Leukemia lymphatica
12.5
8.8
15
13
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.6
8.6
32
103
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
94.3
8.5
9
*
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
94.3
8.5
9
*
Z3231
NOMESCO Finland
Registered nurse
2.6
8.4
71
362
Q62.7
ICD-10 Finland
Congenital vesico-uretero-renal reflux
+∞
8.4
8
*
A12AA12
ATC
[U] calcium acetate
+∞
8.4
8
*
Q61.48
ICD-10 Finland
Nonspecified renal dysplasia
+∞
8.4
8
*
K06.18
ICD-10 Finland
Another gingival hyperplasia
35.1
8.2
10
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.8
8.0
27
81
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
10.1
8.0
15
16
N17.9
ICD-10 Finland
Acute renal failure, unspecified
8.0
7.9
17
23
R4110
NOMESCO Finland
Physiotherapy
2.6
7.8
64
320
ZXD10
NOMESCO Finland
Scheduled procedure
2.5
7.8
80
444
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.2
7.8
34
121
C09CA01
ATC
losartan; oral
2.8
7.7
49
216
TPX10
NOMESCO Finland
Implantation of vascular injection port
7.4
7.5
17
25
Z3226
NOMESCO Finland
Physiotherapist
2.7
7.5
49
219
Q62.0
ICD-10 Finland
Congenital hydronephrosis
+∞
7.3
7
*
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
+∞
7.3
7
*
N25.0
ICD-10 Finland
Renal osteodystrophy
+∞
7.3
7
*
Q60.1
ICD-10 Finland
Renal agenesis, bilateral
+∞
7.3
7
*
RJ421, ,
NOMESCO Finland
+∞
7.3
7
*
KAS20
NOMESCO Finland
Allogenic transplantation of kidney from living donor
+∞
7.3
7
*
Q61.40
ICD-10 Finland
Renal dysplasia of a kidney (multicystic)
+∞
7.3
7
*
XF602
NOMESCO Finland
Bloodpressure monitoring
16.6
7.3
11
7
J01EA01
ATC
trimethoprim; systemic
2.7
7.3
47
208
K06.19
ICD-10 Finland
Gingival hyperplasia UNS
31.4
7.2
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
7.2
49
223
KAC00
NOMESCO Finland
Nephrectomy
41.7
6.8
8
*
Z99.2
ICD-10 Finland
Dependence on renal dialysis
41.7
6.8
8
*
A02BA02
ATC
ranitidine; systemic
2.9
6.7
35
138
E87.5
ICD-10 Finland
Hyperkalaemia
12.9
6.7
11
9
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
12.9
6.7
11
9
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
6.6
46
211
M10.0
ICD-10 Finland
Idiopathic gout
7.9
6.6
14
19
K65.0
ICD-10 Finland
Acute peritonitis
15.0
6.5
10
7
5AB14, ,
NOMESCO Finland
72.3
6.5
7
*
KH1EE
NOMESCO Finland
Urologic ultrasound examination
72.3
6.5
7
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.3
6.4
26
88
I15.9
ICD-10 Finland
Secondary hypertension, unspecified
18.8
6.3
9
5
Q61.3
ICD-10 Finland
Polycystic kidney, unspecified
+∞
6.3
6
*
TJW99
NOMESCO Finland
Other minor procedure in gastrointestinal endoscopy
+∞
6.3
6
*
RJ410, ,
NOMESCO Finland
+∞
6.3
6
*
7151
FHL
Kidney transplantation
+∞
6.3
6
*
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
+∞
6.3
6
*
75302
ICD-8 Finland
Congenital anomalies of urinary system, Hypoplasia et dysplasia renis
+∞
6.3
6
*
RJ190, ,
NOMESCO Finland
+∞
6.3
6
*
H05BX02
ATC
paricalcitol; systemic
+∞
6.3
6
*
5850B
ICD-9 Finland
Chronic renal failure[INSUFFICIENTIA RENIS CHRONICA CUM URAEMIA]
+∞
6.3
6
*
Q60
ICD-10 Finland
Renal agenesis and other reduction defects of kidney
+∞
6.3
6
*
7910X
ICD-9 Finland
Nonspecific findings on examination of urine, Proteinuria[PROTEINURIA NUD]
+∞
6.3
6
*
212
Kela drug reimbursment
Gout
9.1
6.2
12
14
J01MA02
ATC
ciprofloxacin; systemic
2.2
6.1
69
391
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
10.6
6.1
11
11
C10AA01
ATC
simvastatin; oral
2.3
6.0
66
369
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
76
98
12.79
60.35
10.1
4.3
132.02
66.12
ng/l
4.03
70
92
34
31
13.32
33.01
8.7
7.1
73.80
703.50
iu/ml
—
5
6
98
342
5.15
26.60
9.7
3.8
37.28
12.79
mg/mmol
1.92
80
220
105
394
5.06
25.84
7.9
3.4
6.54
7.86
mmol/l
2.71
97
340
65
171
5.41
24.58
9.1
2.4
23.77
22.71
%
0.25
60
154
119
513
4.98
23.99
11.0
3.2
—
—
—
0
0
106
451
4.34
20.93
10.6
3.3
104.96
39.06
e6/l
0.47
98
354
30
44
8.00
20.21
1.9
1.5
—
—
—
0
0
115
553
4.05
18.32
4.3
2.5
74.30
72.90
nmol/l
0.23
109
499
123
626
4.12
17.87
22.5
9.6
1.24
1.22
mmol/l
1.28
117
585
95
409
3.84
17.68
10.1
3.1
0.21
0.22
e6/l
0.07
87
318
82
324
3.84
17.27
6.4
3.6
5118.06
3301.07
umol/l
0.14
77
281
58
182
4.24
16.92
11.2
9.0
0.38
1.22
mmol/l
1.04
50
140
48
133
4.57
16.45
10.0
10.8
22.55
23.52
mmol/l
1.74
48
133
127
685
3.98
16.37
23.5
10.1
1.22
1.22
mmol/l
0.14
112
599
27
48
6.45
15.12
1.5
1.4
218.25
180.45
u/ml
0.31
20
20
38
94
4.87
14.89
15.5
4.4
1.21
1.22
mmol/l
0.45
33
82
27
49
6.32
14.81
1.5
1.4
—
—
—
0
0
112
583
3.48
14.69
11.6
6.2
35.17
35.86
g/l
0.62
107
550
125
706
3.59
14.16
8.4
3.4
0.00
0.00
estimate
-0.00
36
154
64
240
3.60
14.16
4.7
2.9
0.40
0.86
e6/l
1.43
47
149
37
97
4.55
13.43
3.3
2.1
47.29
66.95
ml/min/173m2
1.69
17
38
123
714
3.34
12.78
8.5
3.5
0.00
0.00
estimate
-0.00
32
142
122
706
3.31
12.72
10.3
4.7
0.00
0.00
estimate
-0.00
36
148
60
230
3.43
12.65
4.7
3.1
1.65
2.02
e6/l
0.15
42
140
20
39
5.65
10.10
6.4
13.9
21.27
23.55
mmol/l
1.99
20
39
39
137
3.36
9.20
5.6
3.3
—
—
—
0
0
21
33
7.07
8.80
10.6
3.2
4.78
5.01
kpa
0.82
21
33
25
71
3.93
8.03
6.6
11.6
0.67
0.63
%
0.24
25
71
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
34
6.49
7.96
3.2
5.1
0.23
0.31
u/ml
—
9
24
40
157
3.00
7.78
7.6
11.3
104.27
104.12
mmol/l
0.08
40
157
27
83
3.66
7.75
7.0
12.0
118.37
126.78
g/l
0.94
27
83
129
899
2.58
7.46
10.2
3.9
19.67
25.79
e6/l
—
6
14
29
96
3.41
7.45
2.6
4.4
64.37
66.11
g/l
0.66
29
90
40
167
2.80
6.91
9.4
14.1
22.80
24.92
mmol/l
4.34
40
167
99
629
2.29
6.83
7.4
2.7
181.52
104.66
ug/l
2.99
94
588
70
387
2.33
6.69
11.1
3.6
0.00
0.00
estimate
-0.00
28
141
14
19
7.90
6.55
1.1
1.4
—
—
—
0
0
38
159
2.77
6.51
7.8
9.5
0.29
1.26
mmol/l
1.04
21
115
18
36
5.44
6.39
2.3
1.7
—
—
—
0
0
16
28
6.17
6.31
1.4
4.5
79.27
299.51
mg/l
—
9
21
16
28
6.17
6.31
1.4
4.5
52.38
33.23
mg/l
—
8
21
21
64
3.59
6.08
10.0
4.2
49.78
55.68
%
0.45
21
64
17
34
5.41
6.06
4.5
2.4
124.00
131.44
g/l
0.50
17
25
87
548
2.15
5.87
9.6
3.5
—
—
—
0
0
34
142
2.72
5.82
2.2
2.0
—
—
—
0
0
14
24
6.23
5.66
4.3
2.7
4.40
4.72
e9/l
0.14
14
24
14
24
6.23
5.66
4.9
2.8
58.29
57.92
%
0.03
14
24
33
140
2.67
5.47
2.2
1.9
—
—
—
0
0
15
40
4.00
5.21
1.6
1.4
—
—
—
0
0
19
61
3.37
5.08
10.3
3.7
23.63
24.28
mmol/l
0.36
19
61
85
561
1.99
4.79
16.2
11.9
1.20
1.25
inr
0.24
33
178
42
214
2.26
4.67
2.1
2.0
—
—
—
0
0
9
11
8.54
4.62
5.4
3.9
—
—
—
0
0
15
45
3.55
4.43
1.2
2.1
—
—
—
0
0
14
34
4.38
4.32
1.1
1.2
—
—
—
0
0
7
6
12.07
4.31
1.0
1.2
1258.29
1607.83
miu/ml
—
7
6
15
46
3.47
4.29
1.2
1.9
—
—
—
0
0
12
25
5.07
4.27
1.2
1.5
—
—
—
0
0
9
13
7.22
4.21
1.2
1.5
—
—
—
0
0
51
292
2.05
4.19
2.0
1.5
22.80
21.13
nmol/l
0.23
46
252
33
161
2.29
4.04
2.7
4.9
222.76
288.46
u/l
0.97
33
156
134
1069
2.03
4.01
13.9
7.2
98.62
89.96
u/l
0.78
129
1004
13
32
4.30
3.99
1.2
1.7
—
—
—
0
0
88
616
1.85
3.93
3.4
3.1
—
—
—
0
0
15
49
3.25
3.91
2.8
1.2
—
—
—
0
0
22
92
2.59
3.73
2.5
1.6
—
—
—
0
0
12
30
4.21
3.67
1.3
1.6
—
—
—
0
0
12
30
4.21
3.67
1.3
1.6
—
—
—
0
0
51
313
1.88
3.36
2.6
2.9
—
—
—
0
0
10
24
4.35
3.25
1.4
2.0
—
—
—
0
0
7
11
6.57
3.21
1.0
1.5
—
—
—
0
0
38
215
1.98
3.17
1.9
1.6
1389.74
1247.74
nmol/l
0.42
31
164
55
355
1.79
3.06
2.9
2.5
2.98
2.91
mg/l
0.10
45
308
9
21
4.45
3.04
1.4
2.0
—
—
—
0
0
9
22
4.25
2.92
1.0
1.6
—
—
—
0
0
9
22
4.25
2.92
1.3
1.6
—
—
—
0
0
68
479
1.68
2.73
2.1
1.8
100.72
93.03
pmol/l
0.75
39
269
106
839
1.65
2.69
10.4
6.5
6.61
6.49
mmol/l
0.22
101
782
114
921
1.66
2.65
9.7
10.6
4.28
3.96
e9/l
0.93
100
817
10
31
3.36
2.56
1.4
1.8
—
—
—
0
0
7
17
4.24
2.38
1.0
1.1
—
—
—
0
0
143
1250
1.73
2.23
5.7
3.8
1.49
1.29
mmol/l
2.07
135
1166
23
126
1.95
2.10
6.3
12.5
0.89
1.12
mmol/l
0.06
17
102
7
20
3.60
2.07
1.3
1.1
—
—
—
0
0
8
26
3.17
2.04
1.4
2.0
—
—
—
0
0
8
26
3.17
2.04
1.4
2.0
—
—
—
0
0
50
349
1.60
2.01
1.9
1.8
1.54
1.38
mmol/l
0.49
45
305
161
1481
1.91
1.78
31.4
13.9
20.53
22.30
mg/l
0.31
138
1138
7
24
2.99
1.74
1.4
1.2
—
—
—
0
0
10
40
2.59
1.69
2.0
3.0
—
—
—
0
0
34
228
1.61
1.60
2.2
3.0
2.46
2.44
mmol/l
0.46
27
196
6
21
2.92
1.52
1.3
1.3
—
2.18
—
0
11
143
1291
1.55
1.51
6.3
4.1
1.40
1.43
mmol/l
0.33
136
1200
11
52
2.19
1.48
3.9
12.2
24.32
24.23
mmol/l
0.02
11
52
7
28
2.56
1.46
1.0
1.2
—
—
—
0
0
6
22
2.79
1.44
1.2
1.2
—
—
—
0
0
6
22
2.79
1.44
1.3
1.3
—
2.73
—
0
11
143
1298
1.52
1.39
6.4
4.2
4.38
4.59
mmol/l
1.94
137
1214
9
42
2.20
1.36
1.3
3.0
—
—
—
0
0
10
48
2.15
1.30
1.5
1.2
—
—
—
0
0
8
35
2.34
1.28
1.4
2.1
—
—
—
0
0
8
35
2.34
1.28
1.4
2.1
—
—
—
0
0
144
1321
1.47
1.21
6.5
4.5
2.48
2.75
mmol/l
3.47
136
1225
10
50
2.06
1.19
1.5
1.2
—
—
—
0
0
136
1237
1.42
1.18
32.1
12.0
58.94
86.75
ml/min/173m2
14.89
119
988
60
481
1.37
1.16
3.2
3.6
39.84
36.89
ng/l
0.11
48
317
7
137
0.49
1.15
1.3
1.7
—
—
—
0
0
7
30
2.39
1.13
1.4
1.6
—
—
—
0
0
132
1203
1.38
1.06
8.6
5.3
38.97
39.44
mmol/mol
0.25
126
1134
34
254
1.42
0.98
2.3
1.7
384.03
458.52
pmol/l
0.97
29
222
0
32
0.00
0.96
0.0
1.1
—
70.50
—
0
6
6
33
1.85
0.80
1.5
1.5
—
—
—
0
0
5
24
2.11
0.75
1.4
1.6
—
—
—
0
0
10
61
1.68
0.70
1.3
1.5
115.30
267.82
miu/ml
—
5
31
7
42
1.69
0.69
1.9
2.1
176.14
221.54
pmol/l
—
7
37
7
43
1.65
0.67
2.0
2.4
—
—
—
0
0
5
28
1.81
0.66
2.0
1.6
—
—
—
0
0
8
54
1.50
0.58
2.3
1.8
43.25
39.99
u/l
—
8
49
12
82
1.50
0.56
1.5
1.3
—
—
—
0
0
38
317
1.25
0.54
1.8
2.7
1.05
1.41
mg/l
0.62
30
253
19
246
0.75
0.54
2.0
2.3
—
—
—
0
0
122
1282
0.85
0.43
6.4
4.2
5.73
5.89
mmol/l
0.94
112
1169
106
1126
0.86
0.43
3.6
3.5
—
—
—
0
0
8
56
1.45
0.43
2.4
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
227.87
—
0
15
0
15
0.00
0.41
0.0
1.3
—
37.97
—
0
10
32
370
0.84
0.37
3.8
4.2
24.92
20.96
%
0.85
16
172
6
41
1.48
0.36
1.7
1.3
—
—
—
0
0
124
1294
0.86
0.36
4.3
4.2
2.16
1.95
mu/l
0.39
116
1180
23
273
0.82
0.34
3.0
2.8
0.63
0.73
ug/l
0.35
15
169
111
1054
1.14
0.34
5.5
3.9
17.35
10.76
mm/h
2.31
105
974
11
143
0.75
0.33
3.5
2.5
15.15
12.72
nmol/l
0.53
11
129
27
232
1.19
0.31
3.7
2.9
1520.24
246.38
ng/l
0.65
21
161
8
62
1.30
0.28
1.5
1.5
—
—
—
0
0
19
224
0.83
0.27
1.9
2.1
—
—
—
0
0
10
77
1.32
0.26
1.7
2.6
561.60
175.57
ng/l
—
10
68
24
208
1.18
0.25
1.3
1.2
10.08
37.18
iu/ml
—
5
62
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
33.50
—
0
6
0
12
0.00
0.21
0.0
1.0
—
501.33
—
0
6
38
415
0.89
0.21
1.5
1.4
0.64
1.15
u/ml
1.03
13
91
5
43
1.17
0.21
2.0
1.6
—
—
—
0
0
5
43
1.17
0.21
2.0
1.6
—
—
—
0
0
5
43
1.17
0.21
2.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
9
112
0.79
0.20
1.0
1.0
—
—
—
0
0
15
127
1.20
0.20
1.6
2.4
—
—
—
0
0
6
53
1.14
0.19
2.0
1.9
—
—
—
0
0
11
91
1.22
0.18
1.5
1.3
—
—
—
0
0
16
139
1.17
0.17
5.2
2.8
34.81
31.59
u/l
0.18
16
121
17
150
1.15
0.15
15.6
8.2
—
—
—
0
0
9
106
0.84
0.13
1.4
2.2
—
—
—
0
0
12
105
1.15
0.11
1.6
1.4
202.39
452.22
u/ml
0.47
12
94
20
183
1.10
0.10
3.5
4.4
3.79
8.63
umol/l
1.62
15
157
5
48
1.04
0.09
2.2
1.6
—
—
—
0
0
6
58
1.04
0.08
1.0
1.2
—
—
—
0
0
166
1648
1.11
0.07
43.6
20.4
38.64
40.50
%
4.30
158
1577
40
385
1.05
0.06
1.4
1.8
—
—
—
0
0
166
1649
1.10
0.06
43.4
20.2
4.38
4.56
e12/l
2.86
160
1602
21
206
1.02
0.00
1.4
1.2
2.03
7.83
u/ml
—
6
78
46
459
1.00
0.00
4.1
4.9
2.38
2.71
ug/l
0.12
41
409
18
177
1.02
0.00
1.5
1.4
—
—
—
0
0
9
92
0.98
0.00
1.9
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.9
—
26.00
—
0
7
7
72
0.97
-0.00
3.9
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.8
—
43.80
—
0
5
0
9
0.00
-0.00
0.0
2.3
—
—
—
0
0
5
54
0.92
-0.00
1.6
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.6
—
77.29
—
0
7
0
8
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
59.20
—
0
6
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
225.46
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
104.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
165.80
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY | 3.495 [2.57, 4.75] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.485 |
During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 613 females with Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY | 2.759 [2.09, 3.65] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 799 males with Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY died.
Mortality risk
Mortality risk for people of age
years, who have Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.299% | 0.571% |
| 5 | 2.066% | 2.868% |
| 10 | 5.114% | 7.129% |
| 15 | 10.314% | 13.517% |
| 20 | 17.723% | 22.645% |
Relationships between endpoints
↥Index endpoint: Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY – Renal agenesis and other reduction defects of kidney
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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