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Renal agenesis and other reduction defects of kidney

Endpoint Browser PheWeb

Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — Q60
  • Cause of death: ICD-10 — Q60

2 out of 7 registries used, show all original rules.

174

4. Check minimum number of events

None

174

5. Include endpoints

None

174

6. Filter based on genotype QC (FinnGen only)

174

Control definitions (FinnGen only)

Control exclude
Q17_CONGEN_MALFO_URINARY_SYSTEM

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q6[0-4]
Name in latin
Agenesis/aplasia/hypoplasia/atrophia renis/renum

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1672 714 949
Only index persons 1260 565 695
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.03
Only index persons 0.02 0.02 0.03
Median age at first event (years)
Whole population 14.59 17.97 11.61
Only index persons 24.56 26.79 22.74

-FinnGen-

Key figures

All Female Male
Number of individuals 174 76 98
Unadjusted period prevalence (%) 0.04 0.03 0.04
Median age at first event (years) 42.86 36.53 47.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
158
Matched controls
1580
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q60.0
ICD-10 Finland
Renal agenesis, unilateral
+∞
94.5
81
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
90.5
54.0
58
10
Q60.3
ICD-10 Finland
Renal hypoplasia, unilateral
+∞
49.6
45
*
A11CC03
ATC
alfacalcidol; systemic
85.1
47.9
52
9
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
31.7
44.0
59
29
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
60.0
40.9
47
11
A12AA04
ATC
calcium carbonate; oral
113.2
40.1
42
5
127
Kela drug reimbursment
Transplant complication
83.5
39.5
43
7
Z94.0
ICD-10 Finland
Kidney transplant status
73.0
38.7
43
8
N18.8
ICD-10 Finland
Other chronic renal failure
60.1
38.4
44
10
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
434.3
35.4
34
*
137
Kela drug reimbursment
Uraemia requiring dialysis
107.6
32.2
34
*
L04AA06
ATC
mycophenolic acid; systemic
39.7
29.8
37
12
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
79.5
29.2
32
5
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
66.2
28.4
32
6
TK800
NOMESCO Finland
Hemodialysis
63.7
27.4
31
6
B05DA
ATC
Isotonic solutions
107.8
25.5
27
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
80.7
24.7
27
*
205
Kela drug reimbursment
Chronic hypertension
6.8
23.8
72
172
B03XA02
ATC
darbepoetin alfa; parenteral
51.4
22.2
26
6
N18.0
ICD-10 Finland
End-stage renal disease
58.9
21.8
25
5
H02AB04
ATC
methylprednisolone; systemic
8.3
21.5
52
88
Q60.4
ICD-10 Finland
Renal hypoplasia, bilateral
+∞
21.3
20
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
12.6
21.2
39
40
C03CA01
ATC
furosemide; systemic
6.1
21.2
69
177
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
126.9
21.1
22
*
L04AD01
ATC
ciclosporin; systemic
21.5
20.5
30
17
Z49.1
ICD-10 Finland
Extracorporeal dialysis
46.7
20.2
24
6
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
53.4
19.8
23
5
Q60.2
ICD-10 Finland
Renal agenesis, unspecified
+∞
19.1
18
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
113.7
19.0
20
*
B05DB
ATC
Hypertonic solutions
214.4
19.0
19
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.1
18.3
57
134
N19
ICD-10 Finland
Unspecified kidney failure
28.0
17.9
24
10
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
9.1
17.7
39
55
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
56.8
17.4
20
*
Z49.2
ICD-10 Finland
Other dialysis
71.4
17.1
19
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
23.3
17.0
24
12
M04AA01
ATC
allopurinol; systemic
7.4
16.9
43
76
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
11.4
16.4
31
33
L04AA01
ATC
[U] ciclosporin; systemic
42.8
15.8
19
5
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
176.8
15.8
16
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
16.2
15.7
25
18
Z49.0
ICD-10 Finland
Preparatory care for dialysis
63.0
15.1
17
*
196
Kela drug reimbursment
Paricalcitol and cinacalcet
88.5
14.9
16
*
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
88.5
14.9
16
*
C08CA02
ATC
felodipine; oral
8.8
13.8
30
41
C08CA01
ATC
amlodipine; oral
4.0
13.8
69
255
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
+∞
13.7
13
*
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
31.5
13.3
17
6
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
6.0
13.1
38
79
C09AA02
ATC
enalapril; systemic
5.1
12.7
44
112
Q60.5
ICD-10 Finland
Renal hypoplasia, unspecified
+∞
12.7
12
*
TK820
NOMESCO Finland
Peritoneal dialysis
41.1
12.4
15
*
H05BX01
ATC
cinacalcet; oral
129.0
11.6
12
*
N26
ICD-10 Finland
Unspecified contracted kidney
129.0
11.6
12
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
19.6
11.0
16
9
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
7.4
10.6
25
39
7530A
ICD-9 Finland
Congenital anomalies of urinary system, Renal agenesis and dysgenesis[AGENESIA RENIS]
+∞
10.5
10
*
C07AB02
ATC
metoprolol; systemic
4.3
10.2
41
120
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
21.8
10.0
14
7
B03XA01
ATC
erythropoietin; parenteral
21.8
10.0
14
7
R50.9
ICD-10 Finland
Fever, unspecified
3.7
9.8
48
167
204
Kela drug reimbursment
Leukemia lymphatica
19.0
9.6
14
8
N18
ICD-10 Finland
Chronic kidney disease
106.1
9.5
10
*
V03AE02
ATC
sevelamer; oral
106.1
9.5
10
*
M10.9
ICD-10 Finland
Gout, unspecified
7.9
9.4
21
30
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
39.1
9.1
11
*
RD210
NOMESCO Finland
NA
9.5
9.1
18
21
UKC02
NOMESCO Finland
Cystoscopy
4.0
9.1
38
115
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
6.9
9.0
22
36
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.4
9.0
27
58
N17.9
ICD-10 Finland
Acute renal failure, unspecified
12.6
8.8
15
13
KC1JB
NOMESCO Finland
Miktiocystography with X-ray
94.9
8.5
9
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
94.9
8.5
9
*
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
+∞
8.4
8
*
Q62.7
ICD-10 Finland
Congenital vesico-uretero-renal reflux
+∞
8.4
8
*
Q61.48
ICD-10 Finland
Nonspecified renal dysplasia
+∞
8.4
8
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
8.4
8
*
J01EA01
ATC
trimethoprim; systemic
3.5
8.2
43
153
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
8.2
61
281
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
6.8
7.8
19
31
XPX08
NOMESCO Finland
Intraoperative flow measurement
47.4
7.8
9
*
V03AE01
ATC
polystyrene sulfonate; oral
26.5
7.7
10
*
V03AE03
ATC
lanthanum carbonate; oral
83.9
7.5
8
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
7.3
43
166
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
+∞
7.3
7
*
N39.1
ICD-10 Finland
Persistent proteinuria, unspecified
+∞
7.3
7
*
Q60.1
ICD-10 Finland
Renal agenesis, bilateral
+∞
7.3
7
*
Q61.40
ICD-10 Finland
Renal dysplasia of a kidney (multicystic)
+∞
7.3
7
*
Q62.0
ICD-10 Finland
Congenital hydronephrosis
+∞
7.3
7
*
75301
ICD-8 Finland
Congenital anomalies of urinary system, Agenesis renis unilateralis
+∞
7.3
7
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
7.3
50
216
RS220
NOMESCO Finland
NA
16.8
7.3
11
7
U14
ICPC
Kidney symptom/complaint
16.8
7.3
11
7
R4110
NOMESCO Finland
Physiotherapy
2.8
7.1
53
239
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.6
7.1
24
59
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.7
6.9
30
93
K65.0
ICD-10 Finland
Acute peritonitis
17.7
6.8
10
6
XF602
NOMESCO Finland
Bloodpressure monitoring
17.7
6.8
10
6
E87.5
ICD-10 Finland
Hyperkalaemia
41.9
6.8
8
*
SBB20
NOMESCO Finland
Tooth X-ray examination in conjunction with visit to dentist
23.7
6.8
9
*
J01MA02
ATC
ciprofloxacin; systemic
2.5
6.6
63
329
212
Kela drug reimbursment
Gout
15.1
6.5
10
7
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
72.7
6.5
7
*
RJ411
NOMESCO Finland
NA
72.7
6.5
7
*
KH1EE
NOMESCO Finland
Urologic ultrasound examination
72.7
6.5
7
*
KAS20
NOMESCO Finland
Allogenic transplantation of kidney from living donor
72.7
6.5
7
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
8.7
6.5
13
16
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.2
6.3
23
61
Z99.2
ICD-10 Finland
Dependence on renal dialysis
27.9
6.3
8
*
75302
ICD-8 Finland
Congenital anomalies of urinary system, Hypoplasia et dysplasia renis
+∞
6.3
6
*
KAC10
NOMESCO Finland
Total nephrectomy with capsule
+∞
6.3
6
*
TJW99
NOMESCO Finland
Other minor procedure in gastrointestinal endoscopy
+∞
6.3
6
*
RJ421
NOMESCO Finland
NA
+∞
6.3
6
*
N25.0
ICD-10 Finland
Renal osteodystrophy
+∞
6.3
6
*
RJ190
NOMESCO Finland
NA
+∞
6.3
6
*
ZXA00
NOMESCO Finland
Right side
2.8
6.2
44
192
C09CA01
ATC
losartan; oral
2.8
6.1
41
174
I10
ICD-10 Finland
Essential (primary) hypertension
2.3
6.0
78
469

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
75
93
13.42
61.46
10.0
4.1
132.5
65.0
ng/l
4.07
69
87
112
361
6.90
35.82
17.4
3.7
7.4
7.4
ph
3.12
31
64
93
298
5.56
28.55
9.6
2.6
4.4
4.6
e6/l
0.05
86
260
95
328
5.18
26.18
9.9
3.9
34.8
12.6
mg/mmol
1.73
78
211
91
307
5.12
25.72
8.3
3.1
174.3
290.0
mg/l
0.24
79
197
101
380
4.95
24.64
7.9
3.4
6.6
7.9
mmol/l
2.49
93
327
24
20
13.76
24.36
13.7
3.2
—
—
—
0
0
63
164
5.45
24.13
9.3
2.3
23.2
22.7
%
0.09
58
147
84
287
4.73
22.87
8.7
2.7
503.2
574.4
mosm/kgh2o
2.32
75
240
104
438
4.42
20.97
10.8
3.2
106.7
39.9
e6/l
0.47
96
343
26
31
9.68
20.69
10.5
3.3
—
—
—
0
0
95
389
4.18
19.60
9.9
2.9
—
—
—
0
0
29
43
7.89
19.34
2.0
1.5
—
—
—
0
0
55
157
4.66
18.35
12.1
8.8
—
—
—
0
0
93
397
3.88
17.62
10.3
3.0
0.1
0.2
e6/l
0.61
85
308
120
608
4.14
17.60
22.3
9.5
1.2
1.2
mmol/l
1.09
114
566
107
508
3.87
17.15
12.4
3.7
32.0
106.3
e6/l
0.77
97
365
79
310
3.84
16.81
6.4
3.5
5308.6
3489.7
umol/l
0.13
74
264
39
90
5.30
16.69
15.2
4.5
1.2
1.2
mmol/l
0.42
34
79
21
25
9.42
16.62
7.1
9.8
—
—
—
0
0
124
663
4.03
16.33
23.4
10.0
1.2
1.2
mmol/l
0.04
109
576
47
129
4.62
16.32
9.7
10.9
22.7
23.8
mmol/l
1.74
42
123
16
13
13.45
16.25
1.0
1.9
—
—
—
0
0
17
16
11.67
15.79
1.9
3.5
—
—
—
0
0
55
178
4.06
15.27
11.2
9.0
0.3
1.4
mmol/l
1.38
46
137
109
561
3.52
14.67
11.6
6.2
35.1
35.9
g/l
0.71
104
528
26
46
6.47
14.63
1.4
1.4
218.3
167.0
u/ml
0.46
20
19
82
356
3.47
14.52
3.3
2.6
—
—
—
0
0
122
682
3.64
14.20
8.5
3.4
0.0
0.0
estimate
0.00
36
138
21
32
7.33
13.52
10.6
3.2
2.9
2.7
mmol/l
—
9
23
21
32
7.33
13.52
10.6
3.2
4.8
5.0
kpa
0.86
21
32
16
18
9.69
13.09
1.4
4.1
—
—
—
0
0
120
691
3.37
12.75
8.6
3.4
0.0
0.0
estimate
0.00
32
137
119
683
3.35
12.69
10.4
4.7
0.0
0.0
estimate
0.00
36
142
59
224
3.47
12.67
4.7
3.0
1.7
2.1
e6/l
0.15
41
137
21
37
6.32
11.79
11.4
3.1
7.4
7.4
ph
4.77
21
32
38
117
3.88
11.05
2.0
4.1
60.2
68.2
e9/l
0.60
21
91
17
26
7.14
10.85
1.4
3.7
75.4
322.2
mg/l
—
10
19
17
26
7.14
10.85
1.4
3.7
52.1
32.3
mg/l
—
9
19
68
310
2.96
10.44
5.8
3.2
—
—
—
0
0
138
947
3.21
9.35
11.2
3.9
—
—
—
0
0
30
90
3.82
8.97
2.5
4.1
64.3
66.1
g/l
0.71
30
84
14
22
6.83
8.67
4.9
2.9
58.3
56.9
%
0.12
14
22
14
22
6.83
8.67
4.3
2.7
4.4
4.8
e9/l
0.15
14
22
17
33
5.60
8.60
4.5
2.3
124.0
132.4
g/l
0.59
17
24
25
69
4.06
8.36
1.4
2.8
—
—
—
0
0
28
86
3.69
8.07
1.6
1.3
—
—
—
0
0
32
110
3.34
7.77
7.2
11.1
9.2
9.4
kpa
0.28
32
104
66
338
2.53
7.68
8.0
4.6
—
—
—
0
0
24
69
3.87
7.58
6.5
11.7
0.7
0.6
%
0.21
24
69
16
33
5.24
7.57
5.5
24.1
—
—
—
0
0
125
870
2.55
7.22
10.7
3.8
15.2
25.8
e6/l
—
6
14
26
82
3.55
7.19
6.9
12.0
119.5
127.4
g/l
0.85
26
82
40
164
2.87
7.17
9.5
14.1
22.8
24.9
mmol/l
4.39
40
164
69
375
2.39
6.94
11.1
3.6
0.0
0.0
estimate
0.00
28
135
38
156
2.84
6.78
8.5
9.5
7.4
7.4
ph
—
13
8
17
41
4.49
6.72
4.0
2.9
—
—
—
0
0
38
157
2.82
6.69
8.5
9.4
4.7
5.0
kpa
1.62
38
149
95
606
2.25
6.42
7.4
2.8
177.7
104.1
ug/l
2.65
90
567
41
189
2.53
5.78
2.8
2.5
—
—
—
0
0
77
470
2.14
5.61
11.2
7.5
1.2
1.2
inr
0.11
31
158
36
163
2.52
5.24
2.0
1.8
—
—
—
0
0
5
0
+∞
5.23
1.0
0.0
—
—
—
0
0
66
393
2.09
5.02
9.2
3.2
—
—
—
0
0
27
110
2.72
4.83
7.0
6.4
0.0
0.1
%
1.08
11
34
27
111
2.70
4.75
7.0
6.3
0.0
0.0
%
0.49
11
32
101
713
1.99
4.69
19.9
11.0
0.0
0.0
e9/l
0.64
81
583
12
30
4.22
4.51
1.0
1.2
—
—
—
0
0
56
327
2.05
4.40
3.4
1.9
—
—
—
0
0
28
123
2.52
4.31
13.6
3.2
—
—
—
0
0
7
6
12.08
4.31
1.0
1.2
1258.3
1607.8
miu/ml
—
7
6
47
260
2.11
4.25
3.4
1.7
—
—
—
0
0
79
530
1.90
4.11
6.8
8.0
—
—
—
0
0
131
1039
2.06
4.08
14.0
7.2
99.7
90.5
u/l
0.82
126
975
27
120
2.48
4.06
7.0
6.0
0.3
0.9
%
1.47
11
38
39
204
2.18
4.05
3.7
1.6
—
—
—
0
0
105
775
1.89
4.03
9.2
7.2
0.0
0.0
e9/l
0.11
92
680
49
281
2.04
4.01
2.0
1.5
21.8
21.5
nmol/l
0.04
44
241
17
61
2.98
3.81
10.9
3.5
23.5
24.4
mmol/l
0.53
17
61
104
774
1.85
3.80
9.3
7.2
0.6
0.6
e9/l
0.50
92
675
106
800
1.83
3.64
9.4
7.3
1.9
2.0
e9/l
1.35
94
715
105
793
1.82
3.57
9.4
7.8
0.2
0.2
e9/l
0.65
93
713
37
202
2.06
3.42
1.9
1.6
1373.4
1247.5
nmol/l
0.35
30
155
63
415
1.81
3.33
3.5
2.8
—
—
—
0
0
25
118
2.31
3.30
1.7
1.4
—
—
—
0
0
14
51
2.90
3.06
1.8
1.7
—
—
—
0
0
5
5
10.24
2.99
13.0
10.8
35.5
35.8
%
—
5
5
5
5
10.24
2.99
2.8
2.2
—
—
—
0
0
19
83
2.45
2.96
1.8
1.2
—
—
—
0
0
26
131
2.16
2.94
7.4
9.5
—
—
—
0
0
66
458
1.71
2.84
2.1
1.8
100.7
93.4
pmol/l
0.70
39
255
24
120
2.16
2.77
2.3
1.6
—
—
—
0
0
13
49
2.79
2.69
7.8
4.4
—
—
—
0
0
20
94
2.27
2.67
8.9
3.5
—
—
—
0
0
52
343
1.74
2.66
2.8
2.6
3.0
2.9
mg/l
0.06
43
298
6
11
5.60
2.56
1.3
1.5
—
—
—
0
0
22
110
2.14
2.54
5.6
5.6
0.5
0.4
%
—
6
29
111
899
1.65
2.53
10.8
10.6
4.3
3.9
e9/l
1.05
97
798
47
306
1.73
2.50
8.5
3.5
1.0
1.0
kg/l
—
6
40
5
8
6.39
2.38
1.0
1.4
—
—
—
0
0
5
8
6.39
2.38
1.0
1.0
—
—
—
0
0
7
17
4.24
2.38
3.4
38.8
11.6
10.9
%
—
7
17
9
28
3.33
2.34
1.9
1.1
—
—
—
0
0
51
346
1.67
2.33
10.9
4.7
—
—
—
0
0
13
56
2.43
2.10
6.4
18.5
—
—
—
0
0
6
15
4.10
2.05
1.3
1.3
—
—
—
0
0
139
1222
1.68
2.02
5.7
3.7
1.5
1.3
mmol/l
2.35
131
1143
49
341
1.61
2.00
1.9
1.8
1.5
1.4
mmol/l
0.50
44
299
5
11
4.64
1.95
1.2
1.2
—
—
—
0
0
22
123
1.90
1.91
5.5
12.4
1.0
1.2
mmol/l
0.06
16
99
6
153
0.37
1.87
1.0
1.3
—
—
—
0
0
7
23
3.13
1.82
1.0
1.5
—
—
—
0
0
23
133
1.84
1.81
1.3
1.4
—
—
—
0
0
27
166
1.74
1.74
1.4
1.2
—
—
—
0
0
20
113
1.87
1.69
5.6
13.2
91.4
94.9
%
0.58
20
108
7
25
2.87
1.67
1.4
1.9
—
—
—
0
0
7
25
2.87
1.67
1.4
1.9
—
—
—
0
0
7
25
2.87
1.67
1.4
1.9
—
—
—
0
0
7
25
2.87
1.67
1.4
1.9
—
—
—
0
0
33
219
1.63
1.62
2.2
3.0
2.5
2.4
mmol/l
0.39
26
189
6
140
0.41
1.61
1.3
1.5
—
—
—
0
0
11
50
2.28
1.60
3.9
11.9
24.3
24.1
mmol/l
0.06
11
45
157
1451
1.84
1.60
32.1
13.6
21.0
22.3
mg/l
0.20
134
1110
5
15
3.40
1.53
1.4
1.7
—
—
—
0
0
7
27
2.66
1.53
1.9
2.0
—
—
—
0
0
9
38
2.44
1.48
4.9
2.6
—
—
—
0
0
5
16
3.18
1.45
3.0
2.8
—
—
—
0
0
14
74
1.97
1.43
4.8
10.9
—
—
—
0
0
53
404
1.45
1.39
1.6
1.5
—
—
—
0
0
139
1260
1.51
1.37
6.4
4.0
1.4
1.4
mmol/l
0.40
132
1173
11
54
2.11
1.36
1.0
1.2
—
—
—
0
0
54
417
1.43
1.31
7.4
7.1
—
—
—
0
0
5
18
2.83
1.29
1.6
1.3
—
—
—
0
0
139
1267
1.48
1.26
6.5
4.1
4.4
4.6
mmol/l
1.74
133
1188
25
165
1.60
1.26
1.2
1.2
—
—
—
0
0
27
182
1.57
1.25
2.0
1.8
—
—
—
0
0
6
25
2.45
1.25
1.0
1.0
—
—
—
0
0
21
133
1.66
1.24
2.3
3.6
8.3
9.6
g/l
0.85
21
124
6
26
2.35
1.19
1.0
1.0
—
—
—
0
0
10
50
2.06
1.19
1.5
1.2
—
—
—
0
0
101
880
1.35
1.14
4.5
3.5
—
—
—
0
0
157
1478
1.64
1.12
31.2
12.3
—
—
—
0
0
140
1290
1.44
1.08
6.6
4.5
2.5
2.8
mmol/l
3.21
132
1199
33
242
1.45
1.05
2.3
1.7
388.5
463.1
pmol/l
0.92
28
213
128
1170
1.36
0.98
8.9
5.3
39.6
39.4
mmol/mol
0.08
122
1109
57
468
1.32
0.93
3.5
3.6
40.0
36.3
ng/l
0.13
46
304
8
46
1.77
0.84
15.3
16.8
—
—
—
0
0
19
131
1.51
0.82
1.6
1.6
—
—
—
0
0
5
28
1.81
0.66
12.8
5.3
—
—
—
0
0
11
71
1.59
0.63
3.5
3.9
—
—
—
0
0
0
20
0.00
0.61
0.0
1.3
—
—
—
0
0
6
39
1.56
0.53
1.7
3.9
—
—
—
0
0
11
75
1.50
0.52
1.2
1.2
—
30.0
—
0
6
118
1245
0.84
0.47
6.4
4.1
5.8
5.9
mmol/l
0.15
108
1138
12
86
1.42
0.46
2.2
2.3
—
19.1
—
0
5
21
261
0.78
0.45
3.2
2.8
0.5
0.7
ug/l
1.65
14
162
37
315
1.22
0.45
1.8
2.7
0.8
1.4
mg/l
1.65
30
250
8
59
1.37
0.41
2.9
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
3.3
—
0
6
54
482
1.17
0.40
4.1
2.7
—
—
—
0
0
120
1257
0.85
0.39
4.3
4.2
2.2
1.9
mu/l
0.38
112
1149
9
67
1.36
0.39
1.2
1.1
—
—
—
0
0
6
43
1.41
0.35
1.3
1.6
—
—
—
0
0
11
84
1.33
0.31
2.5
2.1
—
—
—
0
0
11
141
0.77
0.31
3.5
2.5
15.2
13.0
nmol/l
0.44
11
126
18
149
1.23
0.29
1.6
1.7
—
—
—
0
0
20
234
0.84
0.26
1.5
1.7
—
—
—
0
0
23
198
1.19
0.26
1.3
1.2
10.1
37.5
iu/ml
—
5
61
43
390
1.14
0.26
1.4
1.5
2.1
2.0
g/l
0.04
26
223
107
1024
1.12
0.26
5.5
3.9
17.6
10.5
mm/h
2.42
101
946
26
227
1.17
0.25
3.8
2.8
1595.5
253.9
ng/l
0.65
20
156
9
77
1.18
0.24
1.6
2.7
583.4
138.4
ng/l
—
9
68
5
40
1.26
0.22
2.2
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
12.3
—
10.9
—
0
10
0
12
0.00
0.21
0.0
1.6
—
1.1
—
0
12
0
12
0.00
0.21
0.0
1.0
—
250.8
—
0
6
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
303.8
—
0
13
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
37
402
0.90
0.19
1.5
1.4
0.6
1.1
u/ml
1.01
13
89
12
103
1.18
0.14
11.9
5.0
—
—
—
0
0
20
180
1.13
0.14
3.4
4.5
3.8
8.6
umol/l
1.57
15
155
46
485
0.93
0.12
2.7
2.0
—
—
—
0
0
13
146
0.88
0.11
1.1
1.2
—
—
—
0
0
32
340
0.93
0.10
3.5
4.0
—
—
—
0
0
137
1353
1.06
0.08
25.1
14.9
37.7
40.3
%
3.45
104
1069
21
197
1.08
0.06
1.4
1.2
2.0
8.3
u/ml
—
6
73
162
1611
1.08
0.03
44.4
19.9
4.4
4.6
e12/l
2.61
156
1566
162
1613
1.06
0.01
44.4
20.0
7.1
6.8
e9/l
1.16
156
1568
43
438
0.98
0.01
4.2
4.9
2.3
2.7
ug/l
0.15
38
395
10
97
1.03
0.00
1.2
1.4
—
—
—
0
0
11
105
1.05
0.00
1.3
1.4
214.2
452.3
u/ml
0.43
11
94
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
3.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.8
—
18.4
—
0
6
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
4.3
—
0
5
0
5
0.00
0.00
0.0
22.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
97.8
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
79
1.01
0.00
1.4
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
27.1
—
0
6
0
5
0.00
0.00
0.0
18.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
129.0
—
0
7
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
2.6
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
0.00
1.8
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
29.0
—
0.6
—
0
8
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
5.0
—
4.5
—
0
5
0
6
0.00
0.00
0.0
1.0
—
9.0
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
10.8
—
0
6
0
6
0.00
0.00
0.0
2.7
—
1.0
—
0
6
0
5
0.00
0.00
0.0
1.0
—
170.4
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY and mortality.

Females

Parameter HR [95% CI] p-value
Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY 3.495 [2.57, 4.75] < 0.001
Birth year 0.997 [0.99, 1.01] 0.485

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 613 females with Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY died.

Males

Parameter HR [95% CI] p-value
Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY 2.759 [2.09, 3.65] < 0.001
Birth year 0.986 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 799 males with Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY died.

Mortality risk

Mortality risk for people of age

years, who have Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY.

N-year risk Females Males
1 0.299% 0.571%
5 2.066% 2.868%
10 5.114% 7.129%
15 10.314% 13.517%
20 17.723% 22.645%

Relationships between endpoints

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Index endpoint: Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY – Renal agenesis and other reduction defects of kidney

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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