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Vaginal lichen planus

Endpoint Browser PheWeb

VAGINAL_LICHEN_PLANUS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

3 out of 7 registries used, show all original rules.

135

4. Check minimum number of events

None

135

5. Include endpoints

None

135

6. Filter based on genotype QC (FinnGen only)

135

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 135 135 -
Unadjusted period prevalence (%) 0.05 0.05 -
Median age at first event (years) 65.35 65.35 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
107
Matched controls
1070
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N77.8*L43.9
ICD-10 Finland
Vulvovaginal ulceration and inflammation caused by lichen ruber planus
+∞
154.3
107
*
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
85.5
54.6
59
15
ULA02
NOMESCO Finland
Kolposcopy
32.0
50.9
77
79
D07AD01
ATC
clobetasol; topical
30.5
50.3
87
133
L43.9
ICD-10 Finland
Lichen planus, unspecified
78.7
50.2
55
14
LEB00
NOMESCO Finland
Biopsy of vagina
37.9
28.6
36
14
L43.8
ICD-10 Finland
Other lichen planus
30.2
28.3
38
19
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
11.6
27.3
61
109
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
48.9
24.5
29
8
N77.8
ICD-10 Finland
Vulvovaginal ulceration and inflammation in other diseases classified elsewhere
+∞
21.6
20
*
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
15.1
15.1
25
21
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
5.2
14.7
68
267
D07AC01
ATC
betamethasone; topical
4.9
13.6
68
279
SBA00
NOMESCO Finland
Microbiological examinations
46.4
13.6
16
*
J02AC01
ATC
fluconazole; systemic
4.9
12.4
81
418
N89.5
ICD-10 Finland
Stricture and atresia of vagina
121.4
10.6
11
*
G01AA10
ATC
clindamycin; vaginal
4.2
10.3
48
172
A07EA02
ATC
hydrocortisone; rectal
19.1
10.2
15
9
N76.3
ICD-10 Finland
Subacute and chronic vulvitis
44.5
10.2
12
*
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
15.4
10.0
16
12
L43
ICD-10 Finland
Lichen planus
30.3
8.7
11
*
L43.3
ICD-10 Finland
Subacute (active) lichen planus
+∞
8.4
8
*
L43.0
ICD-10 Finland
Hypertrophic lichen planus
36.4
8.2
10
*
TLE00
NOMESCO Finland
Dilatation of vagina
+∞
7.4
7
*
Z70.8
ICD-10 Finland
Other sex counselling
+∞
7.4
7
*
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
5.1
7.3
23
54
EKA10
NOMESCO Finland
Biopsy of cheek
11.2
7.3
13
13
LCA06
NOMESCO Finland
Biopsy of endometrium
3.4
6.4
35
135
ECA20
NOMESCO Finland
Biopsy of gingiva
28.5
6.3
8
*
N94.1
ICD-10 Finland
Dyspareunia
28.5
6.3
8
*
N95.0
ICD-10 Finland
Postmenopausal bleeding
3.9
6.2
26
81

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
23
23
11.85
20.86
1.8
2.0
—
—
—
0
0
96
538
3.72
11.31
3.0
2.1
—
—
—
0
0
23
56
4.75
9.14
1.2
1.2
—
—
—
0
0
111
852
2.70
4.85
3.9
3.7
—
—
—
0
0
46
268
2.09
3.75
5.9
3.5
—
—
—
0
0
43
245
2.11
3.71
1.2
1.3
22.0
33.3
iu/ml
0.52
12
91
33
169
2.26
3.70
1.5
2.0
76.9
126.3
ug/g
0.74
27
128
63
414
1.98
3.67
4.3
2.8
—
—
—
0
0
22
95
2.57
3.56
1.2
1.2
—
—
—
0
0
117
990
2.36
3.00
4.8
4.5
14.3
14.8
pmol/l
1.79
112
903
47
297
1.89
2.95
1.3
1.2
0.8
1.3
u/ml
0.40
11
86
68
491
1.78
2.73
2.0
2.1
91.5
103.6
pmol/l
1.40
34
219
49
321
1.83
2.72
2.6
2.8
—
—
—
0
0
103
845
1.92
2.66
6.6
4.4
—
—
—
0
0
23
117
2.16
2.60
1.5
1.5
—
—
—
0
0
78
594
1.74
2.53
5.9
3.7
0.0
0.0
estimate
—
10
115
129
1179
3.12
2.50
4.9
4.7
1.6
1.6
mmol/l
0.36
121
1081
56
391
1.74
2.46
6.8
5.3
—
—
—
0
0
28
157
1.99
2.46
2.1
1.3
—
—
—
0
0
48
325
1.74
2.33
2.9
2.9
0.1
0.5
e6/l
2.11
32
235
78
603
1.70
2.32
8.1
5.0
0.0
0.0
estimate
—
9
116
135
1290
+∞
2.31
21.7
20.3
90.9
91.2
fl
0.33
135
1271
135
1290
+∞
2.31
21.7
20.2
30.1
30.2
pg
0.46
135
1271
135
1290
+∞
2.31
21.9
20.4
133.4
132.2
g/l
0.63
135
1271
59
425
1.69
2.28
4.3
3.7
125.9
76.8
e6/l
0.32
39
293
87
697
1.70
2.23
8.0
9.4
3.9
3.8
e9/l
0.31
78
618
129
1190
2.89
2.20
5.3
4.7
4.8
4.9
mmol/l
0.28
122
1099
77
607
1.63
2.02
6.0
3.7
0.0
0.0
estimate
—
10
111
50
354
1.66
2.02
3.1
3.1
26.4
40.5
e6/l
0.35
35
264
43
301
1.63
1.79
3.4
3.3
104.3
95.2
%
1.37
43
291
77
622
1.55
1.72
6.5
5.5
0.2
0.2
e9/l
0.28
69
555
128
1191
2.44
1.68
14.0
13.5
21.6
19.8
mg/l
0.25
102
909
75
605
1.54
1.67
6.3
5.3
1.9
2.1
e9/l
0.38
67
548
74
596
1.53
1.65
6.4
5.2
0.5
0.5
e9/l
0.11
65
525
5
14
3.67
1.63
1.0
1.0
—
—
—
0
0
74
599
1.52
1.59
6.4
5.3
0.0
0.0
e9/l
0.56
65
527
123
1126
2.04
1.57
6.4
5.9
39.1
39.5
mmol/mol
0.32
117
1045
54
410
1.53
1.56
1.9
2.2
50.6
58.0
u/l
1.51
49
373
38
268
1.58
1.51
2.1
2.2
2.4
3.5
mg/l
2.10
28
232
36
252
1.58
1.48
1.3
1.3
26.2
12.1
u/ml
0.24
12
97
6
22
2.80
1.45
1.8
2.5
8.3
8.7
kpa
—
6
22
6
22
2.80
1.45
1.8
2.5
5.3
5.0
kpa
—
6
22
60
474
1.48
1.41
6.3
3.4
—
—
—
0
0
43
318
1.52
1.38
6.7
7.6
—
—
—
0
0
32
222
1.58
1.36
1.6
1.8
1323.6
1217.2
nmol/l
0.25
26
159
17
100
1.80
1.31
3.6
3.0
—
—
—
0
0
5
19
2.69
1.22
1.0
1.0
—
—
—
0
0
46
354
1.45
1.20
1.8
1.7
1.2
1.3
mmol/l
0.51
38
294
36
264
1.50
1.19
1.3
1.4
2.3
2.3
g/l
0.09
19
157
37
273
1.49
1.19
4.1
4.3
—
—
—
0
0
80
682
1.42
1.19
4.3
5.9
10.6
10.0
umol/l
0.49
75
643
27
186
1.56
1.18
1.3
1.2
—
—
—
0
0
15
88
1.79
1.17
1.4
1.4
—
—
—
0
0
11
58
1.98
1.16
2.3
4.9
25.6
25.8
mmol/l
0.07
11
58
31
222
1.51
1.14
3.0
3.5
13.4
112.4
ng/l
1.02
19
168
18
113
1.68
1.12
1.9
1.6
—
—
—
0
0
25
172
1.56
1.10
1.5
1.8
—
—
—
0
0
68
569
1.39
1.10
7.0
5.4
55.9
56.0
%
0.02
63
529
28
380
0.67
1.08
2.9
3.7
—
—
—
0
0
9
47
1.98
1.04
1.1
1.1
—
—
—
0
0
125
1178
1.83
1.02
5.2
4.8
5.8
5.9
mmol/l
0.40
118
1082
7
36
1.99
0.98
1.6
3.3
—
—
—
0
0
9
51
1.82
0.96
1.3
1.3
—
—
—
0
0
68
578
1.36
0.96
6.8
5.6
29.5
29.2
%
0.08
63
530
33
250
1.42
0.92
2.1
2.4
6.8
5.7
e6/l
0.20
27
217
36
282
1.38
0.83
1.7
1.8
0.9
0.9
mg/l
0.06
26
227
7
121
0.56
0.82
3.0
4.7
—
—
—
0
0
0
27
0.00
0.78
0.0
4.0
—
33.2
—
0
15
9
53
1.75
0.77
1.2
1.2
—
—
—
0
0
40
327
1.32
0.70
6.3
3.9
0.0
0.0
estimate
—
10
116
7
42
1.70
0.69
1.1
1.4
—
—
—
0
0
37
302
1.31
0.65
1.8
2.5
309.0
7168.1
umol/l
1.83
31
253
60
523
1.27
0.64
11.5
9.2
0.0
0.0
e9/l
0.60
47
431
8
49
1.67
0.63
1.3
1.5
—
—
—
0
0
113
1067
1.36
0.61
17.7
14.9
40.5
39.4
%
2.00
84
756
7
112
0.60
0.61
1.1
2.5
69.1
67.2
g/l
—
7
100
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
41
344
1.28
0.59
3.0
3.0
2137.2
22.6
mg/l
0.50
24
193
6
35
1.75
0.58
10.5
7.4
—
—
—
0
0
119
1135
1.41
0.58
4.7
4.2
1.4
1.2
mmol/l
0.93
112
1037
35
417
0.78
0.56
3.3
3.1
—
—
—
0
0
42
357
1.26
0.54
3.0
2.9
5.7
6.4
mmol/l
0.65
35
286
14
100
1.45
0.54
1.2
1.3
—
—
—
0
0
6
39
1.56
0.53
1.0
1.2
1.3
1.2
g/l
—
6
39
6
39
1.56
0.53
1.8
2.5
—
—
—
0
0
9
63
1.46
0.53
2.0
4.7
—
—
—
0
0
16
118
1.40
0.53
1.3
1.3
—
—
—
0
0
13
92
1.46
0.53
2.5
3.5
—
0.5
—
0
18
6
94
0.62
0.44
1.0
2.5
—
—
—
0
0
5
32
1.58
0.42
2.6
1.8
—
—
—
0
0
5
33
1.53
0.42
1.2
1.2
75.4
98.8
e6/l
—
5
28
12
88
1.40
0.41
1.2
1.2
81.9
172.5
iu/ml
—
7
38
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
2.5
—
—
—
0
0
13
97
1.38
0.41
1.6
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
4.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
8
61
1.33
0.40
1.9
2.0
—
—
—
0
0
17
134
1.31
0.39
3.4
5.6
105.8
103.7
mmol/l
0.84
17
128
9
68
1.35
0.38
2.3
3.3
4.2
4.4
pmol/l
—
9
60
6
47
1.29
0.32
6.3
3.3
22.7
32.1
u/ml
—
6
47
41
368
1.16
0.30
4.0
3.8
14.2
5.4
mg/mmol
0.32
22
198
7
56
1.26
0.30
2.1
1.8
—
—
—
0
0
11
85
1.32
0.29
1.3
1.3
—
—
—
0
0
8
62
1.31
0.28
1.1
1.1
—
—
—
0
0
11
86
1.30
0.27
2.5
6.8
1.4
1.3
mmol/l
0.15
11
81
5
37
1.36
0.24
1.2
3.1
1.5
1.2
mmol/l
—
5
37
5
39
1.29
0.23
1.8
3.6
—
—
—
0
0
30
269
1.15
0.22
4.0
3.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
6.9
—
0
11
0
11
0.00
0.21
0.0
1.0
—
50598.0
—
0
5
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
10
123
0.80
0.21
1.5
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
3.6
—
—
—
0
0
0
12
0.00
0.21
0.0
2.7
—
—
—
0
0
0
13
0.00
0.21
0.0
3.5
—
—
—
0
0
15
127
1.20
0.20
1.8
1.4
—
—
—
0
0
34
372
0.89
0.20
2.0
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
51
1.18
0.19
2.0
2.2
0.9
1.2
%
—
6
51
7
60
1.18
0.18
2.4
8.3
95.7
94.0
%
—
7
60
10
83
1.22
0.16
2.4
2.6
—
—
—
0
0
18
160
1.14
0.15
1.3
1.3
—
—
—
0
0
124
1225
1.15
0.10
13.6
12.5
—
—
—
0
0
18
164
1.11
0.10
2.5
2.1
21.2
22.1
%
0.12
12
142
5
43
1.17
0.10
1.2
3.9
36.0
36.3
mg/l
—
5
35
5
43
1.17
0.10
1.2
3.9
19.8
24.9
mg/l
—
5
34
49
472
1.06
0.08
3.2
3.4
13.0
19.7
ng/l
2.07
25
328
7
64
1.10
0.08
2.4
7.7
0.6
0.7
%
—
7
64
7
64
1.10
0.08
2.4
7.8
1.3
1.4
%
—
7
64
14
127
1.11
0.08
8.9
3.9
1.0
1.0
mmol/l
0.62
14
115
7
66
1.06
0.08
8.1
3.2
—
—
—
0
0
8
75
1.07
0.07
2.9
7.6
—
—
—
0
0
8
75
1.07
0.07
2.7
2.4
—
—
—
0
0
9
84
1.08
0.07
2.4
2.3
4.3
4.3
kpa
—
9
84
9
86
1.05
0.07
1.3
1.3
—
—
—
0
0
9
104
0.86
0.06
2.0
1.3
—
—
—
0
0
47
455
1.05
0.06
8.9
7.8
1.0
1.2
inr
1.38
21
137
10
91
1.11
0.04
1.5
1.3
—
—
—
0
0
15
158
0.94
0.02
1.2
1.2
—
—
—
0
0
11
103
1.07
0.02
3.8
3.8
—
—
—
0
0
10
107
0.93
0.02
4.6
2.5
106.0
69.5
ng/l
—
10
93
29
296
0.97
0.00
1.5
1.4
—
—
—
0
0
10
98
1.02
0.00
4.3
2.5
6.3
6.0
kpa
—
10
98
34
344
0.98
0.00
4.8
3.4
—
—
—
0
0
10
105
0.95
0.00
4.3
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
7.9
—
0
8
9
97
0.92
0.00
2.0
2.6
11.0
10.2
g/l
—
9
89
0
8
0.00
0.00
0.0
2.9
—
—
—
0
0
5
54
0.92
0.00
6.0
2.4
26.0
25.8
mmol/l
—
5
54
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
5
50
1.00
0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
15.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
2.9
—
0
7
0
5
0.00
0.00
0.0
1.2
—
0.7
—
0
5
0
6
0.00
0.00
0.0
22.5
—
77.7
—
0
6
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
27.3
—
0
6
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
7.9
—
0.7
—
0
7
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
8
81
0.99
0.00
1.6
1.8
2.5
1.6
g/l
—
8
73
0
7
0.00
0.00
0.0
1.4
—
11.5
—
0
7
0
5
0.00
0.00
0.0
1.2
—
14.4
—
0
5

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: VAGINAL_LICHEN_PLANUS – Vaginal lichen planus

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).