Sequelae of poliomyelitis

AB1_SEQULAE_POLIO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B91
  • Hospital discharge: ICD-9 138
  • Hospital discharge: ICD-8 04[4]
  • Cause of death: ICD-10 B91
  • Cause of death: ICD-9 138
  • Cause of death: ICD-8 04[4]

2 out of 7 registries used, show all original rules.

279

4. Check minimum number of events

None

279

5. Include endpoints

None

279

6. Filter based on genotype QC (FinnGen only)

279

Control definitions (FinnGen only)

Control exclude
AB1_SEQULEAE_OF_INFECTIONS_AND_PARASITES

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3267 1689 1520
Only index persons 2365 1316 1049
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.04
Only index persons 0.04 0.05 0.04
Median age at first event (years)
Whole population 58.93 58.69 59.11
Only index persons 57.84 57.31 58.50

-FinnGen-

Key figures

All Female Male
Number of individuals 279 130 149
Unadjusted period prevalence (%) 0.06 0.04 0.07
Median age at first event (years) 59.05 57.03 60.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
252
Matched controls
2518
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B91
ICD-10 Finland
Sequelae of poliomyelitis
13788.6
280.0
215
*
1380A
ICD-9 Finland
Late effects of acute poliomyelitis[SEQUELAE POLIOMYELITIDIS]
+∞
73.6
67
*
04499
ICD-8 Finland
Late effects of actue poliomyelitis
+∞
50.8
47
*
N70
ICPC
Poliomyelitis
+∞
45.2
42
*
L28
ICPC
Limited function/disability (L)
3.5
14.9
80
292
SPAT1229
SPAT
Assessment of need for aid
4.2
12.1
49
138
A28
ICPC
Limited function/disability NOS
2.8
9.8
71
309
M89.6
ICD-10 Finland
Osteopathy after poliomyelitis
+∞
9.4
9
*
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
6.8
8.7
21
33
N18
ICPC
Paralysis/weakness
9.9
7.9
15
16
S72.4
ICD-10 Finland
Fracture of lower end of femur
16.3
7.3
11
7
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
4.1
6.5
24
63
M41.9
ICD-10 Finland
Scoliosis, unspecified
11.4
6.4
11
10
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
6.2
53
248
X59
ICD-10 Finland
Exposure to unspecified factor
2.5
6.0
49
221

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
139
1037
1.68
4.35
5.7
4.4
33.3
34.9
g/l
2.13
126
962
49
283
1.89
3.67
5.0
4.2
20.5
45.3
ug/l
0.36
39
247
70
472
1.64
3.06
3.5
3.8
183.7
157.3
ng/l
0.08
62
409
27
135
2.11
3.02
9.0
8.9
—
—
—
0
0
36
201
1.91
2.99
7.6
7.5
—
—
—
0
0
137
1097
1.49
2.73
7.0
5.8
1.2
1.2
mmol/l
0.16
124
980
95
709
1.52
2.65
5.1
5.6
—
—
—
0
0
48
304
1.70
2.65
6.6
6.8
2.1
1.1
mmol/l
1.03
40
244
148
1210
1.48
2.63
9.0
6.5
1.2
1.2
mmol/l
0.56
126
1021
8
21
3.89
2.48
1.6
1.5
—
—
—
0
0
25
132
1.98
2.45
1.2
1.2
—
—
—
0
0
47
307
1.64
2.31
6.8
6.7
11.8
11.6
kpa
0.09
42
295
47
307
1.64
2.31
6.7
6.7
5.3
5.0
kpa
1.96
42
294
17
81
2.17
2.17
2.9
3.9
—
—
—
0
0
73
538
1.48
2.11
7.3
6.8
—
—
—
0
0
93
720
1.44
2.09
3.9
4.2
—
—
—
0
0
79
595
1.46
2.05
1.6
1.6
17.9
20.3
nmol/l
1.06
65
491
24
135
1.85
1.98
5.8
6.1
25.7
24.6
mmol/l
0.89
24
135
35
223
1.65
1.91
3.9
3.4
2.5
2.0
mmol/l
0.47
28
175
25
406
0.58
1.87
5.6
5.3
—
—
—
0
0
29
177
1.71
1.85
4.2
3.2
119.1
81.2
ng/l
0.84
24
155
5
12
4.22
1.83
4.2
18.0
—
—
—
0
0
122
1013
1.36
1.76
2.2
2.0
90.8
92.0
pmol/l
0.09
62
514
93
740
1.39
1.75
5.2
4.1
7.4
7.4
ph
0.18
11
133
48
338
1.51
1.73
2.5
2.2
2.2
2.3
g/l
0.14
43
307
11
48
2.34
1.73
2.1
2.5
—
—
—
0
0
8
31
2.63
1.67
2.4
3.5
—
—
—
0
0
35
232
1.58
1.64
4.0
3.5
—
—
—
0
0
102
841
1.34
1.50
5.1
4.1
827.2
107.1
e6/l
0.55
72
618
64
490
1.40
1.50
4.7
3.0
2.5
2.5
mmol/l
0.75
55
426
120
1014
1.32
1.48
7.2
9.7
1.3
1.3
inr
0.17
32
281
8
165
0.47
1.40
1.6
1.6
—
—
—
0
0
76
606
1.35
1.38
2.6
2.0
2.8
3.3
mg/l
1.19
66
520
9
41
2.23
1.38
1.1
1.1
—
—
—
0
0
139
1210
1.30
1.35
7.3
6.5
10.8
11.7
umol/l
0.57
131
1145
9
43
2.13
1.31
2.8
3.1
—
—
—
0
0
11
55
2.04
1.29
1.4
1.9
—
—
—
0
0
96
804
1.30
1.23
4.7
3.2
2.3
2.4
mmol/l
0.15
84
688
5
19
2.66
1.22
1.0
1.0
—
—
—
0
0
189
1726
1.29
1.21
8.4
7.8
82.9
79.0
u/l
0.41
175
1607
37
267
1.44
1.20
1.2
1.3
—
—
—
0
0
110
940
1.28
1.20
5.2
5.7
0.6
0.6
%
0.11
103
870
115
989
1.28
1.19
6.0
5.9
26.2
26.0
%
0.06
105
908
138
1544
0.79
1.16
3.7
3.7
15.5
15.1
pmol/l
1.13
126
1343
0
36
0.00
1.14
0.0
1.5
—
—
—
0
0
112
966
1.27
1.12
5.9
5.7
3.1
2.8
%
0.51
105
891
44
569
0.73
1.11
3.2
3.3
—
—
—
0
0
43
325
1.38
1.09
2.8
2.2
20.8
21.9
%
0.23
36
277
16
97
1.69
1.09
2.4
2.0
394.1
336.3
ug/l
0.12
16
92
112
971
1.26
1.06
7.0
6.0
8.6
8.8
%
0.26
104
902
89
752
1.27
1.05
4.7
3.5
67.8
148.6
e6/l
0.40
70
581
51
400
1.34
1.04
1.3
1.2
11.2
1.0
u/ml
—
8
105
170
1549
1.25
1.03
5.1
4.7
—
—
—
0
0
7
35
2.03
1.00
1.3
1.2
—
—
—
0
0
189
1746
1.26
0.99
22.3
18.6
37.4
38.6
%
0.77
115
1088
47
368
1.33
0.97
15.4
25.3
1.5
1.3
inr
—
9
46
150
1355
1.23
0.95
5.8
4.9
7.1
6.9
mmol/l
0.60
140
1269
82
696
1.25
0.92
2.7
2.3
58.7
58.4
u/l
0.02
73
646
6
28
2.17
0.92
1.0
1.4
1.1
0.5
nmol/l
—
6
23
6
28
2.17
0.92
1.3
1.1
—
—
—
0
0
77
649
1.26
0.92
4.1
3.3
—
—
—
0
0
47
373
1.31
0.89
1.5
1.5
2.5
2.7
g/l
0.19
23
204
23
162
1.46
0.87
1.3
1.4
—
—
—
0
0
8
44
1.84
0.86
2.1
2.1
—
—
—
0
0
111
981
1.22
0.85
5.8
5.6
58.4
58.5
%
0.01
102
910
91
789
1.23
0.84
3.8
3.5
—
—
—
0
0
6
32
1.89
0.82
2.8
3.2
58.8
60.4
%
—
6
32
25
182
1.41
0.81
5.2
4.4
—
—
—
0
0
69
584
1.24
0.79
1.4
1.6
1.3
1.3
mmol/l
0.09
63
481
5
98
0.50
0.79
1.0
2.5
3.8
4.3
pmol/l
—
5
86
62
520
1.25
0.77
2.0
1.7
1183.5
1162.8
nmol/l
0.07
49
389
44
354
1.29
0.77
2.2
1.9
—
—
—
0
0
5
24
2.10
0.75
1.0
1.4
—
—
—
0
0
7
38
1.86
0.74
1.1
1.2
—
—
—
0
0
96
847
1.20
0.74
3.0
2.5
134.9
143.7
ug/l
0.15
90
759
9
56
1.63
0.73
1.1
1.1
564.9
498.2
mg/l
—
9
51
182
1932
0.83
0.72
3.9
4.3
1.3
1.2
mmol/l
0.24
163
1711
9
57
1.60
0.72
5.0
6.6
—
—
—
0
0
5
26
1.94
0.71
1.2
1.2
—
—
—
0
0
5
26
1.94
0.71
1.0
1.4
—
—
—
0
0
115
1036
1.19
0.70
3.6
4.3
—
—
—
0
0
12
77
1.58
0.69
5.6
3.3
0.2
0.2
g/l
—
5
26
84
736
1.20
0.69
2.3
2.6
—
—
—
0
0
17
119
1.46
0.68
3.1
3.0
—
—
—
0
0
5
28
1.80
0.66
1.8
1.4
—
—
—
0
0
5
28
1.80
0.66
1.2
1.1
152.0
388.5
u/ml
—
5
12
61
522
1.22
0.64
3.3
2.7
5.0
4.5
e6/l
0.17
53
460
8
49
1.65
0.62
3.0
4.0
5.3
5.1
kpa
—
8
49
8
49
1.65
0.62
3.0
4.0
8.9
7.9
kpa
—
8
49
64
736
0.83
0.62
3.9
4.2
—
—
—
0
0
5
30
1.68
0.61
3.0
2.4
3.8
5.3
e9/l
—
5
30
183
1930
0.85
0.61
4.7
4.6
1.7
2.0
mu/l
2.27
162
1686
14
97
1.47
0.60
3.1
3.4
25.4
25.4
mmol/l
0.05
14
92
31
247
1.29
0.60
2.3
1.7
—
—
—
0
0
7
111
0.62
0.59
1.1
1.4
—
—
—
0
0
78
689
1.18
0.59
4.2
3.4
0.3
0.6
e6/l
0.73
59
517
178
1681
1.16
0.56
25.4
21.1
14.2
13.9
%
1.44
172
1647
21
160
1.34
0.55
1.5
1.4
—
—
—
0
0
9
60
1.52
0.55
1.2
1.2
—
4.4
—
0
6
80
713
1.17
0.54
4.0
3.1
6.5
7.1
mmol/l
0.85
69
578
217
2085
1.18
0.53
20.8
17.0
28.7
26.3
mg/l
0.51
183
1698
30
243
1.26
0.52
6.0
3.9
—
—
—
0
0
6
40
1.51
0.52
3.5
2.9
16.3
34.0
u/ml
—
6
40
6
40
1.51
0.52
1.0
1.9
46.8
59.2
%
—
6
40
21
163
1.31
0.50
3.3
3.2
—
—
—
0
0
23
181
1.30
0.50
1.4
1.4
—
—
—
0
0
94
856
1.15
0.48
2.1
2.2
—
—
—
0
0
112
1034
1.14
0.47
5.8
5.5
0.6
0.6
e9/l
0.25
89
891
116
1074
1.14
0.46
6.1
5.7
0.2
0.2
e9/l
0.08
94
939
51
582
0.85
0.46
2.9
3.0
8984.7
6325.3
umol/l
0.12
42
476
200
2076
0.87
0.45
4.9
5.1
6.2
6.1
mmol/l
0.12
178
1849
10
140
0.70
0.44
2.1
4.5
—
—
—
0
0
5
31
1.62
0.43
1.2
1.1
—
—
—
0
0
8
57
1.42
0.42
3.4
3.1
0.9
0.9
nmol/l
—
8
47
5
32
1.57
0.42
1.8
1.2
4.2
8.8
u/l
—
5
25
112
1040
1.13
0.42
5.8
5.5
0.0
0.0
e9/l
0.19
89
899
8
58
1.39
0.42
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
3.4
—
23.2
—
0
5
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
8
60
1.34
0.40
3.1
3.6
7.4
7.4
ph
—
8
49
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
10
71
1.42
0.40
1.6
1.6
—
—
—
0
0
27
226
1.22
0.37
3.0
2.9
67.6
68.6
e9/l
0.04
17
180
53
591
0.87
0.36
4.7
4.4
0.0
0.0
estimate
0.00
16
196
36
312
1.18
0.35
2.3
2.8
1.7
1.8
%
0.38
29
278
193
1995
0.89
0.34
4.3
4.8
1.4
1.5
mmol/l
0.30
174
1777
15
118
1.29
0.34
3.5
2.8
—
—
—
0
0
129
1220
1.11
0.34
9.7
9.3
4.3
4.2
e9/l
0.07
106
1067
6
45
1.34
0.34
1.0
1.3
—
—
—
0
0
24
201
1.21
0.33
2.8
1.9
363.2
359.4
nmol/l
0.03
24
186
100
934
1.11
0.33
9.5
10.3
0.0
0.0
e9/l
0.59
72
774
57
518
1.13
0.30
1.3
1.3
—
—
—
0
0
22
186
1.20
0.29
4.2
3.0
—
—
—
0
0
196
2016
0.91
0.28
4.4
4.8
4.5
4.5
mmol/l
0.11
178
1808
166
1599
1.09
0.28
4.2
4.4
16.5
14.2
mm/h
1.07
159
1450
112
1060
1.09
0.28
5.8
5.6
1.6
1.9
e9/l
1.15
93
938
203
2084
0.90
0.28
4.9
5.5
2.6
2.6
mmol/l
0.21
182
1857
8
66
1.22
0.27
1.3
1.5
186.5
268.9
ug/g
—
8
39
56
513
1.11
0.27
1.9
1.8
447.0
435.7
pmol/l
0.11
45
425
23
197
1.18
0.27
1.6
1.4
—
—
—
0
0
47
516
0.89
0.26
2.6
3.2
1.0
0.8
ug/l
0.65
34
374
10
127
0.78
0.26
2.3
2.5
—
—
—
0
0
55
505
1.11
0.25
3.7
3.9
—
—
—
0
0
34
303
1.14
0.25
1.3
1.2
—
—
—
0
0
85
899
0.92
0.23
4.8
5.3
5.3
3.0
ug/l
0.34
73
788
7
92
0.75
0.23
1.1
1.2
54.6
204.6
u/ml
—
7
83
16
188
0.84
0.22
1.4
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
5.8
—
—
—
0
0
0
10
0.00
0.21
0.0
4.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
9
115
0.78
0.20
1.7
1.3
—
54.9
—
0
9
23
259
0.88
0.19
1.8
1.3
—
—
—
0
0
54
504
1.09
0.19
3.0
3.1
545.2
559.9
mosm/kgh2o
0.25
48
427
54
577
0.92
0.18
3.3
4.1
—
—
—
0
0
28
309
0.90
0.18
1.1
1.3
14.0
48.9
iu/ml
—
7
99
50
467
1.09
0.17
1.5
1.7
1.1
1.5
mg/l
0.92
42
371
7
63
1.11
0.17
4.1
1.7
—
—
—
0
0
110
1060
1.06
0.16
3.5
4.2
0.0
0.0
estimate
0.00
17
207
24
266
0.89
0.16
1.8
1.4
—
—
—
0
0
18
203
0.88
0.16
3.1
3.5
—
—
—
0
0
77
735
1.07
0.15
2.6
2.1
524.9
239.0
u/l
0.40
69
684
14
121
1.17
0.15
1.1
1.3
—
—
—
0
0
197
2005
0.94
0.15
6.3
6.6
40.4
40.9
mmol/mol
0.27
176
1832
8
99
0.80
0.14
1.4
1.3
—
—
—
0
0
110
1066
1.05
0.13
4.7
5.7
0.0
0.0
estimate
0.00
18
203
157
1541
1.04
0.10
3.9
4.3
—
—
—
0
0
23
213
1.09
0.09
1.7
1.3
—
—
—
0
0
20
217
0.92
0.09
2.8
2.0
262.1
149.7
ug/g
0.48
15
174
96
985
0.96
0.09
3.3
4.2
60.8
47.5
ng/l
0.18
72
771
6
57
1.05
0.08
2.2
2.4
—
—
—
0
0
5
63
0.79
0.08
1.0
1.2
—
—
—
0
0
78
758
1.04
0.08
5.0
3.9
22.0
9.0
mg/mmol
0.59
49
470
7
84
0.83
0.07
1.0
1.1
—
—
—
0
0
11
122
0.90
0.07
1.5
2.4
1.3
1.1
%
0.33
11
122
9
86
1.05
0.07
1.8
2.0
—
—
—
0
0
73
712
1.03
0.06
4.2
3.2
110.6
145.2
mg/l
0.13
51
461
225
2234
1.04
0.06
23.9
19.8
139.0
139.6
mmol/l
1.98
218
2168
225
2237
1.03
0.04
24.4
19.9
4.0
4.0
mmol/l
1.67
218
2170
23
240
0.95
0.03
1.3
1.3
288.0
534.3
titre
—
5
56
109
1078
1.02
0.03
3.6
4.3
0.0
0.0
estimate
0.00
18
193
216
2150
1.02
0.02
17.1
16.0
—
—
—
0
0
228
2271
1.02
0.02
28.0
24.7
255.5
240.9
e9/l
2.26
216
2206
228
2271
1.02
0.02
28.4
24.7
91.3
91.8
fl
0.67
220
2232
228
2271
1.02
0.02
28.4
24.6
30.1
30.4
pg
1.43
220
2232
228
2272
1.02
0.01
28.5
24.7
4.3
4.4
e12/l
1.57
216
2192
228
2272
1.02
0.01
28.4
24.7
7.1
6.9
e9/l
0.42
217
2192
228
2272
1.02
0.01
28.5
24.9
129.3
133.2
g/l
3.21
220
2229
222
2214
1.01
0.00
24.4
20.3
72.1
81.6
umol/l
2.98
222
2214
220
2206
0.99
0.00
11.9
11.4
27.2
24.2
u/l
1.18
211
2106
18
179
1.01
0.00
4.6
4.0
—
—
—
0
0
47
473
0.99
0.00
4.5
4.7
1.0
1.0
kg/l
0.46
12
75
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
124.0
—
0
9
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
4.4
—
51.8
—
0
5
9
90
1.00
0.00
2.3
4.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
6.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
3.8
—
0
8
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
12
120
1.00
0.00
1.6
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
1.1
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_SEQULAE_POLIO and mortality.

Females

Parameter HR [95% CI] p-value
AB1_SEQULAE_POLIO 1.391 [1.15, 1.68] < 0.001
Birth year 0.995 [0.99, 1.0] 0.261

During the follow-up period (1.1.1998 — 31.12.2019), 218 out of 652 females with AB1_SEQULAE_POLIO died.

Males

Parameter HR [95% CI] p-value
AB1_SEQULAE_POLIO 1.694 [1.4, 2.05] < 0.001
Birth year 0.988 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 273 out of 623 males with AB1_SEQULAE_POLIO died.

Mortality risk

Mortality risk for people of age

years, who have AB1_SEQULAE_POLIO.

N-year risk Females Males
1 0.116% 0.295%
5 0.895% 1.986%
10 2.244% 4.869%
15 4.346% 9.197%
20 7.669% 15.654%

Relationships between endpoints

Index endpoint: AB1_SEQULAE_POLIO – Sequelae of poliomyelitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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