Tick-borne viral encephalitis

AB1_TICK_BORNE_ENCEPHALITIS_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 A84
  • Hospital discharge: ICD-10 A84
  • Hospital discharge: ICD-9 06[3]
  • Hospital discharge: ICD-8 06[3]
  • Cause of death: ICD-10 A84
  • Cause of death: ICD-9 06[3]
  • Cause of death: ICD-8 06[3]

3 out of 7 registries used, show all original rules.

180

4. Check minimum number of events

None

180

5. Include endpoints

None

180

6. Filter based on genotype QC (FinnGen only)

168

Control definitions (FinnGen only)

Control exclude
AB1_VIRAL_CNS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF13

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 168 89 79
Unadjusted period prevalence (%) 0.03 0.03 0.04
Median age at first event (years) 56.53 55.59 57.60

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
180
Matched controls
1800
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A84.8
ICD-10 Finland
Other tick-borne viral encephalitis
+∞
93.0
81
*
A84.9
ICD-10 Finland
Tick-borne viral encephalitis, unspecified
+∞
76.7
68
*
A86
ICD-10 Finland
Unspecified viral encephalitis
+∞
35.6
33
*
TAB00
NOMESCO Finland
Lumbar puncture
10.5
34.9
44
54
XA800
NOMESCO Finland
Neuropsychological investigation
11.5
33.0
38
41
R50.9
ICD-10 Finland
Fever, unspecified
5.9
27.1
65
158
A87.9
ICD-10 Finland
Viral meningitis, unspecified
+∞
23.4
22
*
AA1AD
NOMESCO Finland
CT of head and brain
4.5
21.7
83
289
A69.2
ICD-10 Finland
Lyme disease
8.3
21.5
31
44
A84.1
ICD-10 Finland
Central European tick-borne encephalitis
+∞
18.0
17
*
R4120
NOMESCO Finland
Occupational therapy
6.2
16.8
32
61
A84
ICD-10 Finland
Tick-borne viral encephalitis
+∞
14.8
14
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.7
12.8
33
82
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
+∞
12.6
12
*
0632A
ICD-9 Finland
Tick-borne viral encephalitis, Central European encephalitis[PUUTIAISEN VÄLITTÄMÄ ENKEFALIITTI (KUMLINGE)]
+∞
9.5
9
*
B34.9
ICD-10 Finland
Viral infection, unspecified
10.9
9.2
17
17
R4150
NOMESCO Finland
Neuropsychological rehabilitation
26.3
7.7
10
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
7.6
96
583
G01*A69.2
ICD-10 Finland
Meningitis (in) Lyme disease
+∞
7.3
7
*
G03.9
ICD-10 Finland
Meningitis, unspecified
31.4
7.2
9
*
S12
ICPC
Insect bite/sting
3.5
7.2
27
87
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.2
6.6
28
98
N29
ICPC
Neurological sympt/complt other
11.6
6.4
11
10
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.2
6.3
16
28
N71
ICPC
Meningitis/encephalitis
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
58
13
65.35
101.44
1.1
1.2
—
—
—
0
0
68
29
37.08
99.51
1.2
1.1
—
—
—
0
0
51
12
58.91
87.75
1.1
1.3
—
—
—
0
0
87
117
13.46
67.65
3.3
2.4
26.27
7.43
au/ml
—
15
7
83
106
13.67
66.91
1.8
1.2
60.74
27.79
au/ml
—
12
7
56
39
20.39
65.14
1.1
1.2
58.19
290.32
e6/l
0.77
31
31
56
39
20.39
65.14
1.1
1.1
99.70
3.37
e6/l
3.05
30
30
44
19
30.33
62.79
1.1
1.2
—
—
—
0
0
102
362
5.19
27.16
3.6
4.5
—
—
—
0
0
31
14
26.42
22.62
1.2
1.1
—
—
—
0
0
25
7
41.12
20.44
1.3
1.4
2.15
2.09
mmol/l
—
25
7
116
687
2.94
10.88
5.9
6.4
8.52
8.50
%
0.02
110
646
116
705
2.82
10.05
5.8
6.2
25.47
27.98
%
1.37
110
667
115
699
2.79
9.91
5.7
6.1
57.53
57.25
%
0.07
110
660
113
685
2.75
9.72
5.7
6.1
2.32
2.85
%
1.03
107
643
111
668
2.73
9.67
5.8
6.1
0.59
0.70
%
1.46
105
621
13
7
19.86
9.07
1.1
1.0
—
—
—
0
0
112
691
2.64
9.06
5.2
6.7
—
—
—
0
0
114
738
2.49
7.90
5.9
6.1
0.58
0.57
e9/l
0.21
93
643
114
739
2.48
7.86
5.9
6.1
0.04
0.04
e9/l
0.62
93
643
116
758
2.49
7.86
6.0
6.6
0.14
0.19
e9/l
3.20
101
672
15
18
8.98
7.48
1.0
1.2
—
—
—
0
0
114
753
2.40
7.33
5.9
6.2
1.77
1.80
e9/l
0.08
97
673
99
638
2.23
6.46
3.4
5.7
1.20
1.22
mmol/l
1.65
86
586
49
241
2.42
6.01
2.4
2.9
2.91
1.97
e6/l
0.21
19
121
134
995
2.36
5.96
3.5
4.0
—
—
—
0
0
49
247
2.35
5.66
1.4
1.9
—
—
—
0
0
121
874
2.17
5.58
7.7
10.0
4.20
4.09
e9/l
0.15
100
760
30
120
2.80
5.56
2.8
4.9
—
—
—
0
0
14
25
5.98
5.50
1.0
1.4
254.50
216.17
u/ml
—
8
12
82
522
2.05
5.20
3.4
3.7
8.92
58.54
e6/l
3.18
53
373
101
696
2.03
5.11
3.8
6.7
1.21
1.22
mmol/l
0.90
89
592
70
425
2.06
5.01
2.5
3.0
0.23
0.42
e6/l
0.74
45
309
82
534
1.98
4.78
2.0
1.9
96.69
94.68
pmol/l
0.11
42
269
68
418
2.01
4.64
2.5
2.9
—
—
—
0
0
88
595
1.94
4.53
2.3
2.0
—
—
—
0
0
73
466
1.95
4.44
2.6
3.1
25.98
192.77
e6/l
0.63
49
353
15
45
3.55
4.43
1.2
1.4
—
—
—
0
0
138
1100
2.09
4.25
3.9
4.0
12.39
11.14
mm/h
0.49
132
1025
142
1153
2.10
4.03
7.4
7.8
74.77
79.33
u/l
0.63
137
1086
105
776
1.85
3.91
5.2
6.9
10.33
11.22
umol/l
0.62
98
740
170
1500
3.40
3.85
16.0
13.3
20.50
22.62
mg/l
0.48
154
1164
6
5
12.34
3.79
1.2
1.0
1255.00
1999.20
miu/ml
—
6
5
12
29
4.36
3.78
1.0
1.4
—
—
—
0
0
109
825
1.81
3.66
3.5
4.5
6.64
6.62
mmol/l
0.01
103
767
22
94
2.53
3.58
1.3
2.3
—
—
—
0
0
6
6
10.28
3.52
1.8
2.0
—
—
—
0
0
10
22
4.75
3.48
1.1
1.1
—
—
—
0
0
62
402
1.83
3.44
6.7
7.1
—
—
—
0
0
10
27
3.86
2.93
1.1
1.1
—
—
—
0
0
83
608
1.68
2.90
3.2
4.6
35.67
35.94
g/l
0.20
78
578
36
206
1.93
2.90
1.2
1.4
108.57
540.80
titre
—
7
50
43
265
1.82
2.75
3.5
3.6
37.24
77.20
ng/l
0.67
33
205
15
62
2.55
2.62
4.3
7.0
—
—
—
0
0
47
309
1.71
2.40
1.4
1.4
1.92
2.67
g/l
2.04
26
189
172
1601
2.67
2.34
17.0
15.7
72.78
77.89
umol/l
3.28
172
1601
5
9
5.68
2.23
2.0
1.8
367.60
1060.00
u/ml
—
5
9
49
337
1.62
2.09
1.5
1.5
21.33
21.87
nmol/l
0.10
37
289
82
636
1.53
2.08
9.5
11.3
1.02
1.22
inr
6.00
12
191
7
21
3.42
1.98
1.1
1.1
—
—
—
0
0
77
594
1.52
1.98
2.4
2.7
149.38
118.95
ug/l
0.54
68
555
6
16
3.84
1.95
1.2
1.3
—
—
—
0
0
25
146
1.83
1.90
3.6
6.9
1.94
1.15
mmol/l
0.54
19
118
52
377
1.53
1.75
2.0
2.7
9243.31
4471.63
umol/l
0.22
45
334
8
30
2.74
1.74
2.0
1.4
—
—
—
0
0
7
24
2.99
1.74
1.1
1.1
—
—
—
0
0
7
24
2.99
1.74
1.1
1.1
—
—
—
0
0
45
317
1.56
1.72
1.4
1.6
0.98
1.18
mg/l
0.30
32
253
0
49
0.00
1.71
0.0
3.8
—
1.53
—
0
44
14
70
2.08
1.64
2.6
2.4
—
—
—
0
0
6
20
3.07
1.59
2.3
1.8
—
—
—
0
0
23
139
1.75
1.57
1.7
2.4
11.69
13.68
nmol/l
0.66
23
130
83
673
1.43
1.57
7.7
9.5
0.00
0.00
e9/l
0.12
60
553
20
117
1.80
1.52
2.0
2.7
0.23
0.22
g/l
0.43
20
108
5
16
3.18
1.45
1.2
1.6
—
—
—
0
0
28
407
0.63
1.43
2.7
2.9
—
—
—
0
0
5
124
0.39
1.43
3.6
3.5
—
—
—
0
0
15
82
1.90
1.40
1.2
1.2
—
—
—
0
0
41
296
1.50
1.40
3.1
2.9
0.45
0.73
ug/l
3.34
23
188
43
314
1.49
1.39
2.4
3.6
—
—
—
0
0
5
17
2.99
1.37
1.2
1.3
—
—
—
0
0
5
17
2.99
1.37
3.6
1.6
—
—
—
0
0
43
317
1.47
1.32
2.0
2.6
5.60
4.32
e6/l
0.33
38
278
148
1356
1.51
1.31
4.6
4.5
1.73
1.90
mu/l
1.23
134
1234
8
34
2.41
1.31
1.3
2.0
—
—
—
0
0
68
548
1.39
1.28
2.9
3.7
64.65
33.68
ng/l
0.32
51
381
14
78
1.86
1.25
1.0
1.1
—
—
—
0
0
46
589
0.71
1.22
2.8
2.8
—
—
—
0
0
5
19
2.68
1.22
1.0
1.3
—
—
—
0
0
29
201
1.53
1.19
1.3
1.6
—
—
—
0
0
15
89
1.75
1.11
1.9
1.8
—
—
—
0
0
26
179
1.53
1.11
1.5
1.7
—
—
—
0
0
52
411
1.37
1.08
4.0
3.7
—
—
—
0
0
14
82
1.77
1.08
3.9
9.2
94.17
93.44
%
0.15
14
82
61
496
1.35
1.06
5.1
4.6
2.98
1.88
ug/l
0.46
52
445
57
460
1.35
1.04
2.1
2.4
51.92
68.57
u/l
0.89
52
430
17
108
1.63
1.01
1.1
1.8
—
—
—
0
0
174
1683
2.02
0.98
22.9
19.6
134.61
137.14
g/l
1.86
174
1662
59
483
1.33
0.98
3.6
3.5
2.32
2.35
mmol/l
0.56
46
433
174
1681
2.05
0.98
22.6
19.5
90.66
90.92
fl
0.32
174
1662
174
1681
2.05
0.98
22.5
19.5
30.26
30.34
pg
0.21
174
1662
174
1680
2.07
0.97
22.8
19.5
39.65
40.76
%
1.49
168
1590
40
310
1.37
0.94
2.1
2.1
3.70
2.99
mg/l
0.50
29
274
18
119
1.57
0.92
1.2
1.2
—
—
—
0
0
13
79
1.70
0.90
3.2
5.4
25.05
24.68
mmol/l
0.15
13
79
8
47
1.73
0.82
1.1
1.1
—
—
—
0
0
6
33
1.85
0.80
1.2
1.2
—
—
—
0
0
121
1110
1.27
0.78
3.5
3.9
14.93
14.77
pmol/l
0.24
105
1008
17
116
1.51
0.77
1.6
1.5
—
—
—
0
0
5
26
1.95
0.71
1.4
1.7
—
—
—
0
0
47
389
1.28
0.71
2.3
2.7
—
—
—
0
0
7
42
1.69
0.69
1.0
1.4
—
—
—
0
0
7
43
1.65
0.67
1.1
1.6
—
—
—
0
0
5
28
1.81
0.66
1.0
4.6
—
—
—
0
0
5
29
1.74
0.64
1.0
1.7
—
—
—
0
0
10
63
1.62
0.63
3.2
3.2
—
—
—
0
0
10
63
1.62
0.63
3.0
3.3
—
—
—
0
0
51
433
1.25
0.63
2.5
2.2
—
—
—
0
0
8
51
1.59
0.61
1.4
1.2
—
—
—
0
0
8
53
1.53
0.59
1.0
1.2
—
—
—
0
0
8
53
1.53
0.59
2.0
1.5
—
—
—
0
0
21
159
1.36
0.58
2.0
1.8
300.43
371.90
nmol/l
1.26
21
146
8
55
1.48
0.57
1.3
1.5
—
—
—
0
0
16
116
1.42
0.56
1.4
1.4
—
—
—
0
0
22
169
1.34
0.56
1.6
1.3
—
—
—
0
0
17
125
1.40
0.56
3.0
7.4
—
—
—
0
0
41
345
1.24
0.54
1.2
1.3
0.55
1.19
u/ml
—
8
106
163
1576
1.36
0.53
12.8
12.0
—
—
—
0
0
23
180
1.32
0.53
4.2
6.9
104.04
104.56
mmol/l
0.24
23
180
19
146
1.34
0.49
1.7
1.6
—
—
—
0
0
151
1450
1.26
0.49
4.4
4.3
5.97
5.88
mmol/l
0.19
135
1340
12
165
0.71
0.49
1.3
1.6
—
—
—
0
0
64
570
1.19
0.49
2.4
3.3
6.20
5.96
ph
—
5
41
17
130
1.34
0.46
1.2
1.3
—
—
—
0
0
6
91
0.65
0.43
1.8
1.2
237.02
159.31
u/ml
—
6
80
8
58
1.40
0.42
1.3
1.4
—
—
—
0
0
8
58
1.40
0.42
1.3
1.4
—
—
—
0
0
25
205
1.25
0.42
1.1
1.2
—
—
—
0
0
5
33
1.53
0.41
2.2
2.1
—
—
—
0
0
8
59
1.37
0.41
1.3
1.4
—
—
—
0
0
8
59
1.37
0.41
1.3
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
8
60
1.35
0.41
1.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
6.30
—
0
5
151
1458
1.22
0.40
4.5
3.9
1.23
1.32
mmol/l
1.01
134
1357
5
35
1.44
0.39
5.4
4.1
—
—
—
0
0
9
70
1.30
0.37
1.4
2.9
0.52
0.63
%
—
9
70
77
715
1.13
0.33
2.5
3.4
0.00
0.00
estimate
—
5
134
20
166
1.23
0.31
1.5
1.5
—
—
—
0
0
39
437
0.86
0.31
2.8
3.8
5.70
8.42
mg/mmol
0.42
24
269
29
251
1.19
0.31
2.3
3.1
2.45
2.45
mmol/l
0.00
24
221
37
414
0.87
0.29
2.5
3.2
42.77
51.54
mg/l
0.18
22
265
25
216
1.18
0.27
1.7
1.9
—
—
—
0
0
9
72
1.26
0.26
1.4
2.9
0.78
1.12
%
—
9
72
28
247
1.16
0.24
1.1
1.2
1.44
8.16
u/ml
—
8
101
41
374
1.12
0.23
1.2
1.4
—
—
—
0
0
8
103
0.77
0.21
1.6
3.8
—
—
—
0
0
30
269
1.14
0.21
1.3
1.3
60.57
32.95
iu/ml
—
7
101
0
11
0.00
0.21
0.0
9.7
—
0.69
—
0
11
0
10
0.00
0.21
0.0
2.0
—
0.89
—
0
10
0
10
0.00
0.21
0.0
1.2
—
13.00
—
0
10
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
3.17
—
0
5
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
27
244
1.13
0.17
1.4
1.7
747.83
1196.77
nmol/l
2.62
18
185
10
82
1.23
0.17
3.4
4.7
—
—
—
0
0
42
451
0.91
0.17
2.3
3.1
8.78
8.14
mmol/l
0.33
33
378
74
706
1.08
0.17
4.0
4.6
0.00
0.00
estimate
—
5
146
7
90
0.77
0.15
1.4
1.1
—
—
—
0
0
21
189
1.13
0.14
1.4
1.6
—
—
—
0
0
16
178
0.89
0.12
1.1
1.4
—
—
—
0
0
16
177
0.89
0.11
1.4
1.2
—
—
—
0
0
6
55
1.09
0.09
7.0
3.0
—
—
—
0
0
140
1385
1.05
0.06
5.3
5.4
39.57
39.63
mmol/mol
0.02
130
1306
152
1533
0.95
0.06
5.3
4.8
2.83
2.82
mmol/l
0.07
134
1434
152
1507
1.06
0.05
5.2
4.4
4.76
4.72
mmol/l
0.21
137
1419
101
1024
0.97
0.04
3.6
3.8
—
—
—
0
0
17
177
0.96
0.01
1.2
1.4
—
—
—
0
0
31
303
1.03
0.01
1.9
3.7
1.02
1.02
kg/l
—
7
38
132
1313
1.02
0.01
20.4
16.5
14.50
14.89
%
0.39
132
1301
42
424
0.99
0.00
1.6
1.7
1.37
1.41
mmol/l
0.10
35
360
150
1501
1.00
0.00
5.0
4.4
1.52
1.45
mmol/l
1.04
135
1403
11
105
1.05
0.00
1.4
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
4.4
—
53.40
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
2.20
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
2210.00
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
6.88
—
0
9
0
8
0.00
-0.00
0.0
3.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
14.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
77.11
—
0
9
0
9
0.00
-0.00
0.0
1.1
—
186.44
—
0
9
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
1.51
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
88
0.90
-0.00
1.3
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
6.63
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
40.29
—
0
8
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: AB1_TICK_BORNE_ENCEPHALITIS_WIDE – Tick-borne viral encephalitis

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).