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Chromophobe cell carcinoma of kidney

C3_KIDNEY_CHROMOPHOBE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C64
  • Cancer registry: Morphology ICD-O-3 8317
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

162

4. Check minimum number of events

None

162

5. Include endpoints

None

162

6. Filter based on genotype QC (FinnGen only)

162

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF9
Name in latin
Carcinoma in situ labii (oris)

Similar endpoints

List of similar endpoints to Chromophobe cell carcinoma of kidney based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 162 57 105
Unadjusted period prevalence (%) 0.04 0.02 0.05
Median age at first event (years) 67.60 63.46 69.86

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
151
Matched controls
1510
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8317/3-C64.9
ICD-O-3
Renal cell carcinoma, chromophobe type of kidney, NOS
+∞
218.2
151
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
1606.8
174.7
140
11
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
547.4
146.9
127
14
KAD01
NOMESCO Finland
Percutaneous endoscopic partial nephrectomy
+∞
40.4
37
*
KAC11
NOMESCO Finland
Total nephrectomy with capsule, transcutaneous
134.8
38.9
40
*
KAD00
NOMESCO Finland
Partial nephrectomy
405.3
33.2
32
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
36.4
25.3
32
11
JN4AD
NOMESCO Finland
Body CT examination
12.6
23.1
43
46
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
14.6
22.6
39
35
B01AB10
ATC
tinzaparin; parenteral
12.5
22.5
42
45
KAC10
NOMESCO Finland
Total nephrectomy with capsule
70.7
21.6
24
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.8
17.7
82
299
WX302
NOMESCO Finland
Thoracal epidural anesthesy
11.1
17.0
33
37
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.7
15.5
50
121
JN4CD
NOMESCO Finland
Very extensive body CT
9.7
14.1
29
36
C64
ICD-10 Finland
Malignant neoplasm of kidney, except renal pelvis
82.4
13.8
15
*
U75
ICPC
Malignant neoplasm of kidney
+∞
13.7
13
*
B01AB05
ATC
enoxaparin; parenteral
3.8
13.3
78
330
TPH07
NOMESCO Finland
Cathetrisation of artery
5.4
12.7
41
97
KA1AE
NOMESCO Finland
Kidney ultrasound examination
15.1
12.3
20
15
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.4
11.6
98
533
JN4BD
NOMESCO Finland
Extensive body CT
4.8
10.9
39
102
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
95.1
8.5
9
*
N02BE01
ATC
paracetamol; systemic, rectal
5.2
8.2
142
1134
WX402
NOMESCO Finland
General anaesthesia
3.4
7.5
38
134
N02AX02
ATC
tramadol; systemic, rectal
2.6
7.5
85
497
R4110
NOMESCO Finland
Physiotherapy
2.7
6.6
55
267
L01XE04
ATC
[U] sunitinib; oral
72.7
6.5
7
*
KA3LT
NOMESCO Finland
Njurlesion coagulation
72.7
6.5
7
*
197
Kela drug reimbursment
Sunitinib
72.7
6.5
7
*
KAC00
NOMESCO Finland
Nephrectomy
72.7
6.5
7
*
D30.0
ICD-10 Finland
Benign neoplasm: Kidney
19.0
6.3
9
5
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.9
6.3
42
179
ZXA00
NOMESCO Finland
Right side
2.5
6.1
54
271

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
72
134
8.87
41.40
1.2
1.4
—
—
—
0
0
128
632
5.89
21.66
4.0
4.1
—
—
—
0
0
32
49
7.89
20.88
3.5
2.4
0.2
0.2
g/l
0.08
25
18
123
660
4.59
16.80
9.7
5.8
1.2
1.2
mmol/l
1.38
115
601
36
79
5.57
16.35
7.4
8.8
—
—
—
0
0
105
542
3.66
14.30
2.5
2.1
—
—
—
0
0
113
632
3.61
13.13
7.2
4.7
35.5
35.4
g/l
0.10
106
601
52
181
3.76
12.90
6.5
7.5
-0.7
1.2
mmol/l
3.07
43
153
83
395
3.26
12.42
4.3
3.0
—
—
—
0
0
105
583
3.28
11.91
8.0
8.6
1.1
1.3
inr
1.25
31
154
117
709
3.34
11.11
10.3
6.8
1.2
1.2
mmol/l
0.84
96
603
87
456
2.96
10.53
2.4
2.5
—
—
—
0
0
41
138
3.64
10.51
8.9
8.1
—
—
—
0
0
68
313
3.02
10.40
3.3
2.6
2.3
3.3
e6/l
1.05
60
270
82
421
2.92
10.24
4.3
3.0
0.1
0.4
e6/l
4.12
67
318
86
457
2.88
10.01
4.5
3.2
358.6
192.8
e6/l
0.18
70
357
48
184
3.29
10.00
8.9
6.0
1.0
1.0
mmol/l
0.00
43
170
150
1105
5.83
9.79
12.0
7.7
81.9
77.8
u/l
0.48
144
1038
82
437
2.77
9.32
7.9
4.0
7.4
7.4
ph
1.24
17
78
134
930
3.55
9.19
4.9
4.2
—
—
—
0
0
90
514
2.69
8.76
5.1
3.6
44.8
89.8
e6/l
0.86
75
382
70
381
2.47
7.18
2.7
3.0
—
—
—
0
0
40
167
2.85
6.98
1.4
1.2
—
—
—
0
0
76
453
2.28
6.12
5.5
3.7
2.4
2.3
mmol/l
1.12
66
399
55
296
2.30
5.54
3.2
2.8
586.0
566.7
mosm/kgh2o
0.31
47
250
111
803
2.21
5.21
11.0
9.3
4.1
4.2
e9/l
0.23
96
700
155
1360
4.23
4.86
20.8
15.6
34.9
23.5
mg/l
3.10
145
1097
45
247
2.14
4.19
1.7
1.9
30.1
29.6
s
0.37
45
237
48
279
2.02
3.81
5.1
3.1
2.5
2.4
mmol/l
0.92
43
251
65
421
1.91
3.77
3.8
4.3
—
—
—
0
0
38
208
2.08
3.52
4.4
2.4
25.9
22.7
%
0.77
31
182
69
465
1.84
3.48
4.3
3.3
1677.3
63.8
mg/l
0.81
45
309
155
1408
3.33
3.22
22.2
14.8
—
—
—
0
0
24
113
2.32
3.20
4.9
4.4
—
—
—
0
0
69
478
1.77
3.10
4.0
3.2
7.1
7.8
mmol/l
0.40
54
395
70
491
1.75
2.99
4.9
4.1
18.4
9.9
mg/mmol
0.81
42
319
51
326
1.82
2.97
1.3
1.3
—
—
—
0
0
122
1005
1.87
2.95
5.0
4.3
—
—
—
0
0
123
1017
1.87
2.92
4.6
4.2
15.3
12.8
mm/h
0.96
114
933
16
68
2.50
2.65
2.9
3.1
—
—
—
0
0
21
111
2.02
2.13
4.4
3.6
—
—
—
0
0
85
672
1.56
2.05
4.4
3.6
0.0
0.0
estimate
0.00
25
115
71
543
1.55
1.96
3.6
2.6
274.9
139.7
ug/l
1.02
62
502
6
16
3.85
1.95
1.8
3.0
—
—
—
0
0
26
153
1.83
1.94
6.5
4.1
—
—
—
0
0
12
52
2.41
1.93
2.9
3.4
—
—
—
0
0
51
363
1.59
1.92
5.2
4.1
0.0
0.0
estimate
0.00
23
117
83
660
1.53
1.91
5.5
4.8
0.0
0.0
estimate
0.00
24
124
50
356
1.59
1.87
9.1
6.4
—
—
—
0
0
6
17
3.62
1.85
2.8
1.5
—
—
—
0
0
155
1457
2.48
1.79
14.6
11.1
26.1
26.7
u/l
0.14
150
1405
20
111
1.91
1.78
4.8
3.6
—
—
—
0
0
25
150
1.79
1.76
6.7
4.2
6.0
5.7
kpa
0.81
25
143
147
1351
1.95
1.70
5.2
4.9
4.4
4.5
mmol/l
0.22
135
1234
53
394
1.51
1.62
4.3
2.8
396.8
7074.4
umol/l
1.66
45
336
6
20
3.07
1.59
1.2
1.3
—
—
—
0
0
81
658
1.46
1.59
4.5
3.6
0.0
0.0
estimate
0.00
25
125
26
163
1.71
1.58
3.2
5.2
5.0
32.7
ug/l
0.56
18
138
6
21
2.93
1.52
4.5
2.8
—
—
—
0
0
77
624
1.45
1.51
11.6
9.8
0.0
0.0
e9/l
0.52
66
498
145
1341
1.77
1.43
5.1
4.9
1.4
1.4
mmol/l
0.81
132
1210
0
39
0.00
1.35
0.0
5.1
—
—
—
0
0
41
300
1.49
1.33
4.6
3.7
—
—
—
0
0
61
484
1.42
1.30
6.3
5.6
—
—
—
0
0
112
989
1.43
1.28
4.7
3.7
15.1
14.9
pmol/l
0.53
103
876
148
1385
1.79
1.27
5.7
5.5
2.6
2.6
mmol/l
0.09
133
1255
6
25
2.45
1.25
2.3
3.5
56.2
62.9
%
—
6
25
6
25
2.45
1.25
2.3
2.8
3.6
5.5
e9/l
—
6
25
21
134
1.65
1.22
1.8
1.5
—
—
—
0
0
144
1343
1.65
1.19
5.6
5.0
6.2
6.1
mmol/l
0.12
134
1218
141
1309
1.60
1.18
4.5
4.4
1.4
1.3
mmol/l
0.63
128
1178
19
119
1.68
1.18
3.2
3.3
323.4
191.1
ng/l
0.46
19
109
25
169
1.57
1.16
1.3
1.3
—
—
—
0
0
7
136
0.49
1.16
1.1
1.5
—
—
—
0
0
37
274
1.45
1.13
1.5
1.6
1.4
1.3
mg/l
0.13
27
221
5
21
2.42
1.10
1.0
1.2
—
—
—
0
0
7
33
2.17
1.07
1.6
1.3
—
—
—
0
0
84
721
1.34
1.06
6.0
6.0
0.2
0.2
e9/l
0.12
70
630
134
1239
1.47
1.05
5.6
4.5
1.9
2.0
mu/l
0.08
121
1107
84
722
1.34
1.04
6.0
5.8
1.7
1.9
e9/l
0.56
70
635
82
703
1.34
1.03
6.0
5.6
0.6
0.6
e9/l
0.26
69
596
82
704
1.33
1.02
6.0
5.6
0.0
0.0
e9/l
0.35
70
603
20
133
1.57
1.00
1.9
1.6
—
—
—
0
0
52
420
1.35
0.96
3.1
3.0
0.7
0.8
ug/l
0.47
39
273
17
110
1.61
0.95
2.1
2.1
—
—
—
0
0
10
169
0.56
0.94
1.3
1.4
—
—
—
0
0
14
86
1.69
0.94
1.5
1.5
—
—
—
0
0
6
28
2.19
0.92
1.7
2.7
—
—
—
0
0
6
30
2.04
0.88
2.8
4.8
—
—
—
0
0
44
352
1.34
0.86
2.8
1.9
3.1
3.2
mg/l
0.09
35
308
140
1322
1.43
0.80
6.8
6.5
39.8
41.0
mmol/mol
0.92
131
1223
44
356
1.32
0.80
1.7
1.6
15.3
20.5
nmol/l
2.18
37
301
8
48
1.70
0.80
3.6
3.7
23.4
31.4
mg/l
—
8
40
8
48
1.70
0.80
3.6
3.7
78.6
207.5
mg/l
—
8
40
0
24
0.00
0.80
0.0
1.7
—
—
—
0
0
0
24
0.00
0.80
0.0
1.7
—
—
—
0
0
0
24
0.00
0.80
0.0
1.7
—
—
—
0
0
24
176
1.43
0.78
1.3
1.3
760.0
493.7
titre
—
8
41
38
302
1.34
0.78
1.7
1.6
1297.0
1203.6
nmol/l
0.22
24
232
81
717
1.26
0.73
5.5
5.0
4.6
2.6
ug/l
0.35
74
638
47
390
1.29
0.71
2.1
1.7
1.5
1.3
mmol/l
0.42
38
320
127
1189
1.32
0.70
27.9
16.3
38.6
40.0
%
0.97
87
819
7
42
1.70
0.69
1.0
1.1
—
—
—
0
0
7
43
1.66
0.67
1.0
1.6
—
—
—
0
0
6
101
0.58
0.64
2.5
2.0
—
—
—
0
0
25
193
1.35
0.62
1.0
1.3
4.7
9.1
u/ml
—
10
69
5
30
1.69
0.62
3.8
2.0
—
—
—
0
0
5
30
1.69
0.62
2.4
3.0
9.0
8.4
kpa
—
5
30
5
30
1.69
0.62
2.4
3.0
5.4
5.0
kpa
—
5
30
0
21
0.00
0.60
0.0
3.2
—
—
—
0
0
0
21
0.00
0.60
0.0
3.2
—
105.8
—
0
21
0
21
0.00
0.60
0.0
3.2
—
4.1
—
0
21
0
23
0.00
0.59
0.0
1.7
—
—
—
0
0
0
23
0.00
0.59
0.0
1.7
—
—
—
0
0
6
98
0.60
0.54
1.2
1.6
—
—
—
0
0
12
83
1.48
0.53
5.1
6.4
23.6
24.8
mmol/l
0.59
12
83
17
127
1.38
0.52
2.6
2.5
67.9
66.3
g/l
0.35
17
114
10
68
1.50
0.48
6.0
4.8
—
—
—
0
0
5
33
1.53
0.41
1.2
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.9
—
—
—
0
0
0
16
0.00
0.41
0.0
2.5
—
682.6
—
0
5
5
34
1.49
0.40
1.6
1.1
—
—
—
0
0
42
367
1.19
0.40
3.9
3.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.9
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
5
36
1.40
0.38
2.4
3.3
7.4
7.4
ph
—
5
30
18
144
1.28
0.37
4.1
4.1
—
—
—
0
0
25
209
1.23
0.37
1.1
1.3
25.4
37.2
iu/ml
—
10
70
16
127
1.29
0.35
4.1
2.8
3.9
4.5
kpa
0.86
16
119
20
164
1.25
0.34
1.9
1.7
—
—
—
0
0
7
57
1.24
0.29
1.1
1.3
—
—
—
0
0
63
584
1.13
0.28
2.1
2.1
97.1
92.9
pmol/l
0.24
26
326
5
37
1.36
0.24
1.6
1.2
—
—
—
0
0
5
39
1.29
0.23
2.6
2.3
—
—
—
0
0
23
261
0.86
0.22
1.3
1.3
1.9
2.6
g/l
1.51
11
144
5
41
1.23
0.22
6.2
1.9
23.4
24.9
mmol/l
—
5
34
15
126
1.21
0.22
1.1
1.5
—
—
—
0
0
5
42
1.20
0.21
1.2
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
8.5
—
7.4
—
0
5
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
15
174
0.85
0.19
1.1
1.3
—
—
—
0
0
63
598
1.09
0.17
3.8
4.0
127.9
47.9
ng/l
0.55
50
442
8
70
1.15
0.16
1.3
1.2
—
—
—
0
0
9
80
1.13
0.15
4.4
3.2
1.3
0.1
e6/l
—
9
80
7
90
0.77
0.15
2.7
2.5
1.0
1.4
%
—
7
90
11
96
1.16
0.10
1.0
1.3
—
—
—
0
0
31
291
1.08
0.10
3.5
5.1
—
—
—
0
0
5
43
1.17
0.10
1.2
1.7
—
—
—
0
0
5
46
1.09
0.09
1.0
1.1
—
—
—
0
0
6
56
1.07
0.09
1.0
1.7
—
—
—
0
0
6
70
0.85
0.08
3.3
2.3
—
—
—
0
0
8
74
1.09
0.07
5.0
3.5
—
—
—
0
0
8
77
1.04
0.07
1.4
1.3
—
—
—
0
0
17
157
1.09
0.07
1.3
1.5
—
—
—
0
0
10
111
0.89
0.06
1.1
1.5
—
—
—
0
0
20
210
0.95
0.04
23.3
27.1
—
1.3
—
0
26
15
141
1.07
0.03
1.4
2.5
73.3
73.7
e9/l
—
9
113
45
439
1.03
0.03
3.2
3.2
—
—
—
0
0
10
92
1.09
0.03
1.3
1.2
—
17.6
—
0
6
46
452
1.02
0.01
3.6
4.3
—
—
—
0
0
22
219
1.01
0.00
1.8
1.8
—
—
—
0
0
45
445
1.02
0.00
2.1
2.0
174.1
228.3
u/l
0.51
40
417
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.2
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
7.2
—
0.6
—
0
5
0
5
0.00
0.00
0.0
2.2
—
8.6
—
0
5
0
5
0.00
0.00
0.0
3.4
—
50.8
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
422.6
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
8.4
—
700.1
—
0
9
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
19.2
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
11.6
—
—
—
0
0
0
7
0.00
0.00
0.0
15.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
5
52
0.96
0.00
3.6
13.0
—
—
—
0
0
0
6
0.00
0.00
0.0
13.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_KIDNEY_CHROMOPHOBE – Chromophobe cell carcinoma of kidney

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).