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Benign neoplasm: Appendix

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_APPENDIX

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D12.1&
  • Hospital discharge: ICD-8 — 21131
  • Cause of death: ICD-10 — D12.1&
  • Cause of death: ICD-8 — 21131

2 out of 7 registries used, show all original rules.

397

4. Check minimum number of events

None

397

5. Include endpoints

None

397

6. Filter based on genotype QC (FinnGen only)

384

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D12
Name in latin
Neoplasma benignum appendicis vermiformis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2109 1194 910
Only index persons 1983 1129 854
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 65.07 63.69 66.86
Only index persons 64.78 63.24 66.80

-FinnGen-

Key figures

All Female Male
Number of individuals 384 214 170
Unadjusted period prevalence (%) 0.08 0.08 0.08
Median age at first event (years) 66.06 63.84 68.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
397
Matched controls
3970
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D12.1
ICD-10 Finland
Benign neoplasm: Appendix
+∞
307.7
386
*
JEA01
NOMESCO Finland
Laparoscopic appendectomy
24.3
123.5
94
50
UJF32
NOMESCO Finland
Coloscopy
8.6
101.1
263
741
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
21.8
91.9
72
40
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
11.9
57.0
62
61
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
7.6
51.4
82
131
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
7.2
44.4
74
123
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
9.3
42.1
54
66
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
9.8
40.1
49
56
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
13.5
38.0
37
30
D37.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Appendix
403.2
37.7
37
*
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
7.6
36.7
56
84
UJF30
NOMESCO Finland
Ileoscopy through colon
4.5
30.1
86
230
JFB31
NOMESCO Finland
Laparoscopic right hemicolectomy
11.1
25.6
28
27
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
3.0
21.3
126
533
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.9
19.2
115
487
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
16.0
159
852
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
3.7
15.8
55
166
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
15.6
171
956
WX402
NOMESCO Finland
General anaesthesia
2.7
15.2
104
466
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.2
13.5
37
94
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
10.2
13.4
26
27
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
12.9
133
712
K35.9
ICD-10 Finland
Acute appendicitis, unspecified
3.9
12.8
40
112
8240/3-C18.1
ICD-O-3
Neuroendocrine tumor, NOS, of appendix
134.1
12.5
13
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.0
12.4
60
222
JAH01
NOMESCO Finland
Laparoscopy
4.5
12.2
31
74
B01AB05
ATC
enoxaparin; parenteral
2.2
12.2
163
966
K35.1
ICD-10 Finland
Acute appendicitis with peritoneal abscess
13.1
11.8
20
16
C18.19
ICD-10 Finland
Malignant tumor in appendix other or unspecified histology
+∞
11.5
11
*
C18.11
ICD-10 Finland
Malignant tumor of the appendix invasive carcinoma
+∞
10.5
10
*
8480/1-C18.1
ICD-O-3
Low grade appendiceal mucinous neoplasm of appendix
+∞
10.5
10
*
21131
ICD-8 Finland
Benign neoplasm of other parts of digestive system, Appendicis
+∞
10.5
10
*
JEA00
NOMESCO Finland
Appendectomy
3.6
10.1
35
105
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.5
9.8
66
289
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
9.8
67
296
JFB30
NOMESCO Finland
Right hemicolectomy
7.2
9.5
22
32
P01AB01
ATC
metronidazole; oral, rectal
1.9
9.1
175
1154
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
9.0
105
580
Z2221
NOMESCO Finland
Medical doctor
2.0
8.5
124
741
K38.9
ICD-10 Finland
Disease of appendix, unspecified
91.9
8.4
9
*
JFB21
NOMESCO Finland
Laparoscopic ileocaecal resection
91.9
8.4
9
*
JFB20
NOMESCO Finland
Ileocaecal resection
13.4
7.9
13
10
TPH07
NOMESCO Finland
Cathetrisation of artery
2.4
7.9
59
270
C18.10
ICD-10 Finland
Malignant tumor of the appendix without histology
45.9
7.7
9
*
K63.5
ICD-10 Finland
Polyp of colon
4.6
7.5
18
41
D37.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Colon
7.1
7.4
17
25
N02BE01
ATC
paracetamol; systemic, rectal
2.6
7.2
363
3182
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
7.2
202
1466
JFA45
NOMESCO Finland
Endoscopic contact coagulation in colon
20.5
7.2
10
5
A02BC05
ATC
esomeprazole; systemic
1.8
7.2
176
1228
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
4.2
7.2
19
47
R4110
NOMESCO Finland
Physiotherapy
1.9
7.1
125
787
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.6
7.0
41
167
JN3AD
NOMESCO Finland
Abdominal CT examination
2.3
7.0
55
258
WX002
NOMESCO Finland
Sedation and analgesia
2.0
7.0
94
543
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
6.8
98
577
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
2.7
6.8
37
145
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
6.8
143
951
B01AB10
ATC
tinzaparin; parenteral
2.3
6.6
51
237
ZXD35
NOMESCO Finland
Usual procedure
3.8
6.6
20
55
K92.1
ICD-10 Finland
Melaena
2.9
6.4
30
109
JFB51
NOMESCO Finland
Other laparoscopic resection of colon
+∞
6.3
6
*
JN4AD
NOMESCO Finland
Body CT examination
2.3
6.3
49
229
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
3.0
6.2
28
99
WX892
NOMESCO Finland
Monitored bed care
2.6
6.2
37
152
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
3.5
6.2
21
62
D06
ICPC
Abdominal pain localized other
2.5
6.2
38
159

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
136
397
4.69
43.79
3.6
4.0
4.11
38.55
ug/l
1.09
110
340
134
388
4.70
43.57
1.5
1.3
—
—
—
0
0
230
1464
2.36
15.46
5.9
4.5
34.81
35.42
g/l
0.96
220
1373
236
1537
2.32
14.79
3.0
2.6
—
—
—
0
0
49
152
3.54
13.51
3.5
2.8
76.37
2047.33
u/ml
1.00
41
128
92
426
2.51
12.31
1.2
1.3
—
—
—
0
0
173
1054
2.14
12.03
2.9
2.4
—
—
—
0
0
251
1791
2.09
11.11
7.7
6.2
12.19
11.22
umol/l
0.72
244
1692
201
1326
2.04
11.01
2.5
2.2
—
—
—
0
0
100
511
2.28
10.59
2.4
2.4
2.42
2.32
g/l
0.88
95
466
71
315
2.53
10.29
2.9
2.3
31.93
32.06
u/l
0.01
59
264
325
2605
2.37
10.13
10.3
7.5
78.86
78.32
u/l
0.10
312
2413
105
557
2.20
10.11
2.4
2.4
12.10
12.74
umol/l
0.45
100
512
93
479
2.23
9.58
2.5
2.5
20.88
22.18
%
0.45
85
410
209
1451
1.93
9.37
12.1
9.5
0.00
0.00
e9/l
0.31
169
1193
90
463
2.22
9.27
1.4
1.2
—
—
—
0
0
221
1570
1.92
9.17
7.2
6.0
26.41
27.43
%
0.73
212
1466
218
1545
1.91
9.08
7.4
6.1
8.94
8.67
%
0.58
210
1443
217
1538
1.91
9.01
7.2
5.8
2.88
2.84
%
0.07
209
1432
212
1493
1.90
8.96
7.2
5.8
0.63
0.66
%
0.36
202
1386
78
388
2.26
8.68
3.5
2.7
5.94
8.45
umol/l
1.32
68
336
259
1976
1.89
8.24
6.0
4.5
6.55
6.73
mmol/l
0.79
246
1858
216
1557
1.85
8.24
7.1
5.7
58.06
57.31
%
0.37
207
1455
253
1920
1.88
8.14
12.4
9.0
4.31
4.13
e9/l
0.59
214
1695
305
2465
2.02
8.07
4.9
4.3
13.06
12.83
mm/h
0.11
280
2237
212
1535
1.82
7.82
7.2
6.3
—
—
—
0
0
370
3251
3.03
7.77
22.5
15.0
27.07
23.70
mg/l
1.06
314
2606
145
939
1.86
7.67
5.1
4.2
—
—
—
0
0
222
1646
1.79
7.42
7.3
5.6
0.04
0.04
e9/l
0.10
183
1421
228
1704
1.79
7.41
7.9
6.5
1.20
1.22
mmol/l
1.55
200
1455
221
1638
1.79
7.38
7.3
5.6
0.61
0.59
e9/l
0.62
183
1412
226
1697
1.77
7.11
7.6
5.9
0.20
0.19
e9/l
0.13
192
1493
190
1368
1.75
6.84
3.2
2.7
137.11
131.17
ug/l
0.13
183
1245
131
847
1.82
6.82
2.8
2.1
2.78
3.12
mg/l
1.31
117
717
222
1675
1.74
6.72
7.4
5.7
1.73
1.99
e9/l
1.67
190
1490
219
1656
1.72
6.49
21.6
15.2
1.29
1.28
inr
0.05
63
473
209
1561
1.72
6.47
6.7
5.5
1.20
1.22
mmol/l
2.15
196
1408
328
2797
1.99
6.39
27.9
17.9
15.20
15.16
%
0.04
323
2758
13
16
8.36
6.38
2.3
3.6
56.15
62.75
nmol/l
0.36
13
16
154
1076
1.70
5.97
3.9
3.1
30.07
31.70
u/l
0.46
143
1023
106
668
1.80
5.89
3.9
3.9
64.92
224.09
ng/l
1.78
94
541
90
541
1.86
5.82
4.0
3.0
1.15
2.14
e6/l
1.55
52
298
58
307
2.04
5.43
2.3
2.2
0.22
0.21
g/l
0.31
53
285
258
2096
1.66
5.36
3.9
3.2
51.23
50.63
u/l
0.04
251
1933
148
1048
1.66
5.33
4.4
3.4
20.22
105.70
e6/l
0.78
114
813
189
1427
1.62
5.24
2.2
2.0
91.36
94.73
pmol/l
0.45
97
748
151
1080
1.64
5.20
3.3
3.3
—
—
—
0
0
131
907
1.66
5.10
4.0
3.2
—
—
—
0
0
82
498
1.81
5.09
2.3
1.9
—
—
—
0
0
163
1196
1.62
5.02
5.4
3.8
43.36
86.25
e6/l
0.99
119
867
136
957
1.64
4.95
4.2
3.2
1.24
0.48
e6/l
0.51
104
724
15
34
4.54
4.79
1.0
1.1
—
—
—
0
0
377
3474
2.69
4.78
14.5
10.8
24.96
25.36
u/l
0.25
370
3342
282
2380
1.64
4.69
4.8
4.1
—
—
—
0
0
70
418
1.82
4.57
2.4
2.6
1.76
1.78
%
0.06
64
376
85
543
1.72
4.41
4.1
3.3
0.85
0.81
mmol/l
1.17
77
505
120
840
1.61
4.38
9.4
6.5
—
—
—
0
0
103
695
1.65
4.35
3.9
3.3
526.18
545.61
mosm/kgh2o
0.37
88
595
100
670
1.66
4.34
3.9
3.0
2.46
2.46
mmol/l
0.17
84
589
383
3578
3.00
4.31
33.4
22.2
248.52
246.03
e9/l
0.29
375
3481
383
3580
2.98
4.27
33.8
22.2
39.51
40.07
%
1.04
362
3342
383
3580
2.98
4.27
33.4
22.2
6.72
6.73
e9/l
0.02
373
3473
383
3581
2.97
4.25
33.4
22.2
4.40
4.46
e12/l
1.38
372
3475
55
313
1.88
4.18
3.7
3.5
1.44
2.26
mmol/l
0.89
43
254
54
308
1.87
4.07
1.4
1.4
—
—
—
0
0
55
316
1.86
4.06
3.7
3.5
6.00
5.81
kpa
0.71
49
302
115
812
1.59
4.00
1.3
1.4
—
—
—
0
0
176
1366
1.52
4.00
2.2
2.3
78.72
78.31
nmol/l
0.07
156
1199
69
429
1.74
3.92
9.0
6.1
104.45
103.87
mmol/l
0.52
69
429
16
54
3.05
3.89
1.1
1.2
10.22
8.23
u/l
—
10
44
264
2245
1.53
3.79
6.0
4.5
—
—
—
0
0
140
1051
1.51
3.65
4.7
3.8
7.40
7.40
ph
0.16
26
186
152
1163
1.50
3.61
4.0
3.4
2.34
2.35
mmol/l
0.83
132
1018
364
3364
1.99
3.60
21.9
14.3
—
—
—
0
0
25
114
2.27
3.43
2.2
2.2
280.32
320.35
ug/l
0.12
25
105
93
656
1.55
3.18
3.4
3.0
0.75
0.80
ug/l
0.18
68
421
332
3020
1.61
3.07
5.0
4.9
1.97
1.96
mu/l
0.06
313
2716
6
10
6.07
2.70
1.0
1.4
—
—
—
0
0
41
247
1.74
2.62
1.7
2.3
—
—
—
0
0
10
30
3.39
2.62
1.1
1.1
—
—
—
0
0
28
150
1.93
2.59
1.4
2.0
1.48
1.53
g/l
0.11
21
134
12
44
2.78
2.57
2.4
1.3
—
—
—
0
0
98
731
1.45
2.53
3.2
2.7
3.75
4.44
e6/l
0.47
86
658
12
45
2.72
2.47
1.1
1.0
—
—
—
0
0
96
720
1.44
2.40
1.9
1.7
1.27
1.24
mg/l
0.05
78
558
57
384
1.57
2.38
8.5
7.0
0.67
1.44
mmol/l
0.81
42
313
135
1080
1.38
2.32
3.2
3.1
1127.87
1379.52
ng/l
0.49
120
923
57
388
1.55
2.28
2.1
1.6
—
—
—
0
0
191
1618
1.35
2.27
6.0
5.3
0.00
0.00
estimate
-0.00
42
293
56
381
1.55
2.25
8.7
7.0
13.56
11.98
kpa
1.22
51
368
56
381
1.55
2.25
8.7
7.0
5.26
5.15
kpa
0.46
51
366
42
268
1.63
2.20
11.7
7.2
—
—
—
0
0
160
1325
1.35
2.19
4.3
3.9
29.79
63.15
ng/l
0.72
114
976
52
356
1.53
2.04
2.3
2.2
155.03
150.33
ug/g
0.02
43
284
9
32
2.85
2.01
1.2
1.2
—
—
—
0
0
91
698
1.39
1.99
1.8
1.7
1078.35
1173.04
nmol/l
0.39
71
526
76
566
1.42
1.96
1.2
1.3
17.31
36.96
iu/ml
2.69
24
191
10
39
2.60
1.95
1.2
1.3
—
—
—
0
0
10
39
2.60
1.95
1.3
1.6
—
—
—
0
0
188
1614
1.31
1.95
4.3
3.9
0.00
0.00
estimate
0.50
44
319
25
143
1.80
1.94
1.8
3.0
—
—
—
0
0
45
303
1.55
1.91
2.9
2.7
74.20
69.81
e9/l
0.34
31
246
60
433
1.45
1.84
1.4
1.3
547.69
496.23
titre
0.10
13
106
81
619
1.39
1.81
1.5
1.4
2.58
2.57
g/l
0.01
48
363
31
194
1.65
1.78
1.3
1.4
—
—
—
0
0
189
1638
1.29
1.77
4.3
3.9
0.00
0.01
estimate
0.50
42
287
341
3211
1.44
1.76
4.7
4.9
6.05
6.01
mmol/l
0.22
318
2906
7
24
2.95
1.73
1.9
1.2
—
—
—
0
0
332
3115
1.40
1.72
6.6
6.1
39.67
40.33
mmol/mol
0.63
317
2880
95
752
1.35
1.70
3.8
3.8
—
—
—
0
0
349
3306
1.46
1.68
5.4
5.3
2.61
2.71
mmol/l
1.21
325
3019
49
347
1.47
1.66
1.5
1.5
—
—
—
0
0
44
305
1.50
1.65
1.4
1.5
—
—
—
0
0
43
298
1.50
1.62
1.6
1.5
—
—
—
0
0
16
84
1.94
1.62
4.2
2.6
1.58
1.67
mg/l
0.23
16
76
5
14
3.60
1.62
2.8
5.0
—
—
—
0
0
21
122
1.76
1.58
2.8
1.8
—
—
—
0
0
30
194
1.59
1.53
2.8
2.6
—
—
—
0
0
19
108
1.80
1.53
1.5
1.2
—
—
—
0
0
5
15
3.36
1.53
1.6
1.8
785.40
825.27
u/ml
—
5
15
27
171
1.62
1.50
11.8
8.8
—
—
—
0
0
151
1294
1.27
1.49
3.8
3.7
5.88
5.80
ph
0.12
13
95
7
29
2.44
1.40
1.1
2.1
—
—
—
0
0
42
301
1.44
1.36
2.2
2.7
14.64
7.71
ug/l
0.36
35
265
5
17
2.96
1.36
1.4
1.3
0.95
1.05
g/l
—
5
17
56
423
1.38
1.36
1.5
1.6
—
—
—
0
0
10
47
2.16
1.34
3.3
1.9
33.40
33.17
pg
—
10
47
107
889
1.28
1.34
3.3
2.7
369.81
7363.26
umol/l
3.92
97
767
11
54
2.07
1.34
1.5
1.6
—
—
—
0
0
102
843
1.28
1.33
1.7
1.6
20.89
20.88
nmol/l
0.00
91
710
8
34
2.38
1.30
3.7
2.8
—
—
—
0
0
10
48
2.11
1.28
1.4
1.1
—
—
—
0
0
8
157
0.50
1.28
2.8
3.7
—
—
—
0
0
9
45
2.02
1.24
1.2
1.4
34.28
32.33
g/l
—
9
39
12
63
1.93
1.24
1.7
1.6
—
—
—
0
0
5
19
2.65
1.22
3.2
1.6
—
—
—
0
0
5
19
2.65
1.22
1.4
2.4
14.20
13.54
%
—
5
19
32
223
1.47
1.21
2.8
2.2
9.66
13.02
nmol/l
1.88
27
202
85
696
1.28
1.20
1.4
1.2
1.70
1.36
u/ml
0.19
17
176
131
1133
1.23
1.15
6.0
5.1
2.43
2.87
ug/l
0.32
117
1005
68
544
1.30
1.14
1.2
1.3
21.38
11.61
u/ml
0.36
19
213
19
119
1.63
1.14
1.8
3.0
0.38
0.20
g/l
—
8
38
7
30
2.36
1.13
1.0
1.6
—
—
—
0
0
30
210
1.46
1.12
1.4
1.3
—
—
—
0
0
17
104
1.66
1.11
4.5
2.9
—
—
—
0
0
336
3211
1.30
1.10
4.5
4.7
1.45
1.48
mmol/l
0.79
317
2936
32
231
1.42
1.03
3.2
4.8
—
—
—
0
0
124
1078
1.22
1.03
3.7
3.8
10.75
9.78
mg/mmol
0.07
75
670
30
215
1.43
1.01
1.6
1.6
0.86
1.32
g/l
1.85
30
195
14
84
1.69
0.99
1.1
1.1
—
—
—
0
0
337
3233
1.28
0.99
4.6
4.7
4.53
4.63
mmol/l
0.95
318
2979
121
1054
1.21
0.98
4.3
4.1
—
—
—
0
0
16
100
1.63
0.98
1.4
1.4
185.71
283.92
ug/g
—
7
57
27
191
1.44
0.97
1.1
1.2
161.33
130.31
iu/ml
0.11
11
72
12
69
1.76
0.97
1.3
1.2
—
—
—
0
0
33
243
1.39
0.96
1.7
1.4
—
—
—
0
0
0
32
0.00
0.95
0.0
1.1
—
—
—
0
0
14
86
1.65
0.92
1.4
1.2
—
—
—
0
0
51
407
1.29
0.89
1.6
1.4
—
—
—
0
0
14
87
1.63
0.88
1.2
1.1
—
—
—
0
0
23
162
1.45
0.86
1.3
1.2
—
—
—
0
0
119
1048
1.19
0.85
3.2
3.1
7.51
7.35
mmol/l
0.14
94
864
324
3109
1.23
0.84
4.0
4.2
1.33
1.28
mmol/l
0.58
300
2819
12
73
1.66
0.82
2.0
2.2
—
—
—
0
0
14
89
1.59
0.82
4.9
2.7
101.88
89.50
ug/min
—
8
54
31
234
1.35
0.80
1.2
1.2
—
—
—
0
0
19
131
1.47
0.80
3.8
4.5
—
—
—
0
0
27
202
1.36
0.75
1.2
1.3
—
—
—
0
0
114
1014
1.17
0.73
3.1
3.2
50.06
182.39
mg/l
0.83
69
646
7
39
1.81
0.73
1.6
1.6
15.26
16.95
ug/l
—
7
39
11
68
1.64
0.72
3.8
3.4
—
—
—
0
0
15
101
1.50
0.71
4.6
7.1
1.20
1.18
mmol/l
0.05
15
91
34
267
1.30
0.69
5.5
4.1
—
—
—
0
0
5
29
1.73
0.64
2.2
2.3
—
—
—
0
0
17
121
1.42
0.63
1.1
1.0
—
—
—
0
0
261
2486
1.15
0.62
4.2
4.0
14.77
14.83
pmol/l
0.14
246
2226
15
105
1.45
0.61
1.0
1.1
—
—
—
0
0
12
80
1.52
0.60
2.9
2.7
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
6
37
1.63
0.56
2.3
1.9
84.65
90.05
%
—
6
37
100
900
1.15
0.55
1.5
1.6
1.35
1.34
mmol/l
0.04
86
739
23
178
1.31
0.54
1.3
1.3
—
—
—
0
0
98
882
1.15
0.54
4.6
4.2
0.00
0.00
estimate
-0.00
42
286
22
170
1.31
0.52
4.2
4.5
—
—
—
0
0
6
96
0.62
0.52
1.3
1.4
—
—
—
0
0
7
49
1.44
0.46
4.9
2.5
3.34
4.63
e9/l
—
7
49
7
50
1.41
0.45
1.6
1.4
—
—
—
0
0
7
51
1.38
0.44
4.0
2.1
—
—
—
0
0
7
51
1.38
0.44
4.7
2.9
57.71
58.22
%
—
7
51
31
258
1.22
0.43
3.8
4.6
0.90
0.59
%
—
10
93
81
733
1.13
0.42
1.4
1.8
429.34
441.22
pmol/l
0.15
70
602
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
26
213
1.24
0.42
3.0
2.7
—
—
—
0
0
0
15
0.00
0.41
0.0
2.7
—
75.70
—
0
10
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.7
—
9.10
—
0
19
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
6
42
1.44
0.35
1.0
1.2
—
—
—
0
0
9
124
0.72
0.35
1.1
1.1
—
—
—
0
0
78
716
1.11
0.33
4.1
4.2
1.02
1.02
kg/l
0.34
14
95
6
46
1.31
0.33
1.2
1.1
—
—
—
0
0
13
101
1.30
0.32
4.2
5.8
—
—
—
0
0
10
75
1.34
0.30
1.1
1.2
—
—
—
0
0
31
269
1.17
0.30
4.3
4.8
0.00
0.16
%
—
9
97
118
1113
1.09
0.29
2.8
3.1
—
—
—
0
0
7
57
1.23
0.29
1.9
1.3
—
—
—
0
0
14
112
1.26
0.28
1.6
1.6
—
—
—
0
0
8
62
1.30
0.28
1.9
3.3
—
—
—
0
0
29
256
1.14
0.24
4.5
4.8
0.14
0.12
%
—
7
82
5
38
1.32
0.23
3.8
1.7
—
—
—
0
0
5
40
1.25
0.22
1.0
1.2
—
—
—
0
0
5
41
1.22
0.22
1.2
1.1
—
—
—
0
0
5
42
1.19
0.21
1.2
1.2
—
—
nmol/l
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
3.38
—
0
10
0
12
0.00
0.21
0.0
4.1
—
15.38
—
0
12
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
56.15
—
0
13
6
48
1.25
0.20
3.5
2.8
—
—
—
0
0
32
290
1.11
0.18
4.3
4.6
0.80
0.93
%
—
10
118
12
100
1.21
0.18
5.7
10.2
—
—
—
0
0
7
58
1.21
0.18
2.1
3.5
—
—
—
0
0
22
247
0.88
0.17
1.5
1.4
—
—
—
0
0
7
61
1.15
0.17
1.7
1.2
3.00
4.02
mmol/l
—
7
55
7
62
1.13
0.17
1.7
1.2
16.29
7.49
e6/l
—
7
49
7
62
1.13
0.17
1.7
1.4
294.29
190.74
e6/l
—
7
50
7
63
1.11
0.17
1.1
1.2
92.13
16.46
u/l
—
7
53
7
63
1.11
0.17
1.6
1.3
43.43
62.83
mmol/l
—
7
58
9
80
1.13
0.15
2.3
3.8
—
—
—
0
0
94
902
1.06
0.15
4.4
3.7
—
—
—
0
0
9
81
1.11
0.15
1.1
1.8
—
—
—
0
0
28
304
0.92
0.13
3.1
1.9
367.14
380.63
nmol/l
0.17
28
277
27
292
0.92
0.12
3.6
3.4
—
—
—
0
0
5
44
1.14
0.10
1.2
1.2
—
—
—
0
0
5
45
1.11
0.10
1.2
1.2
—
—
—
0
0
32
340
0.94
0.09
1.6
1.6
—
—
—
0
0
5
47
1.06
0.09
1.2
1.2
0.62
0.54
nmol/l
—
5
42
6
58
1.04
0.08
1.7
1.2
—
—
—
0
0
7
65
1.08
0.08
4.0
2.7
—
—
—
0
0
7
65
1.08
0.08
1.1
1.6
—
—
—
0
0
12
131
0.91
0.05
1.2
1.8
—
—
—
0
0
16
152
1.05
0.02
1.3
1.4
—
—
—
0
0
16
167
0.96
0.01
1.4
1.6
—
—
—
0
0
34
336
1.01
0.00
3.5
4.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
68
0.88
0.00
2.7
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
0.00
2.5
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
1.90
—
0
6
6
67
0.89
-0.00
2.5
1.4
—
—
—
0
0
6
66
0.91
-0.00
2.5
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
18.30
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
53
0.94
-0.00
2.8
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.7
—
—
—
0
0
6
67
0.89
-0.00
2.5
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
60
1.00
-0.00
1.2
1.8
66.42
57.79
%
—
6
60
7
71
0.99
-0.00
1.7
1.2
389.29
486.38
mg/l
—
7
66
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
12
120
1.00
-0.00
1.4
1.2
—
2.11
—
0
9
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
6
59
1.02
-0.00
1.0
1.7
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_APPENDIX and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_APPENDIX 1.145 [0.93, 1.41] 0.206
Birth year 0.999 [0.99, 1.01] 0.73

During the follow-up period (1.1.1998 — 31.12.2019), 186 out of 979 females with CD2_BENIGN_APPENDIX died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_APPENDIX 1.264 [1.04, 1.54] 0.019
Birth year 0.984 [0.97, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 219 out of 743 males with CD2_BENIGN_APPENDIX died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_APPENDIX.

N-year risk Females Males
1 0.116% 0.274%
5 0.71% 1.536%
10 1.883% 3.573%
15 3.424% 6.429%
20 5.936% 10.78%

Relationships between endpoints

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Index endpoint: CD2_BENIGN_APPENDIX – Benign neoplasm: Appendix

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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