Benign neoplasm: Appendix

CD2_BENIGN_APPENDIX

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D12.1&
  • Hospital discharge: ICD-8 21131
  • Cause of death: ICD-10 D12.1&
  • Cause of death: ICD-8 21131

2 out of 7 registries used, show all original rules.

362

4. Check minimum number of events

None

362

5. Include endpoints

None

362

6. Filter based on genotype QC (FinnGen only)

362

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D12
Name in latin
Neoplasma benignum appendicis vermiformis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2109 1194 910
Only index persons 1983 1129 854
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 65.07 63.69 66.86
Only index persons 64.78 63.24 66.80

-FinnGen-

Key figures

All Female Male
Number of individuals 362 199 163
Unadjusted period prevalence (%) 0.07 0.07 0.07
Median age at first event (years) 64.90 62.46 67.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
320
Matched controls
3199
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D12.1
ICD-10 Finland
Benign neoplasm: Appendix
+∞
323.0
310
*
UJF32
NOMESCO Finland
Coloscopy
9.1
71.3
217
602
JEA01
NOMESCO Finland
Laparoscopic appendectomy
30.0
51.1
69
29
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
21.4
36.4
54
30
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
14.9
30.7
52
41
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
7.7
25.3
62
97
D37.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Appendix
141.0
25.0
26
*
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
7.6
23.8
58
90
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
14.1
18.9
32
25
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
7.0
17.1
43
69
UJF30
NOMESCO Finland
Ileoscopy through colon
4.4
16.9
66
178
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
7.8
15.9
37
53
JFB31
NOMESCO Finland
Laparoscopic right hemicolectomy
16.1
15.1
24
16
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
3.1
14.5
96
392
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
12.0
134
731
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
11.3
126
683
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
11.3
111
564
B01AB05
ATC
enoxaparin; parenteral
2.4
11.2
130
717
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
4.7
10.1
34
79
K35.1
ICD-10 Finland
Acute appendicitis with peritoneal abscess
14.0
9.8
16
12
JFB30
NOMESCO Finland
Right hemicolectomy
8.5
9.5
20
25
21131
ICD-8 Finland
Benign neoplasm of other parts of digestive system, Appendicis
+∞
9.4
9
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
3.4
9.4
47
156
WX402
NOMESCO Finland
General anaesthesia
2.7
9.3
69
296
8240/3-C18.1
ICD-O-3
Neuroendocrine tumor, NOS, of appendix
51.4
8.7
10
*
8480/1-C18.1
ICD-O-3
Low grade appendiceal mucinous neoplasm of appendix
+∞
8.4
8
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.4
8.2
77
375
N02BE01
ATC
paracetamol; systemic, rectal
2.5
7.8
282
2392
C18.19
ICD-10 Finland
Malignant tumor in appendix other or unspecified histology
46.1
7.7
9
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.7
7.6
54
225
C18.11
ICD-10 Finland
Malignant tumor of the appendix invasive carcinoma
81.9
7.4
8
*
JFB20
NOMESCO Finland
Ileocaecal resection
16.2
7.3
11
7
JAH01
NOMESCO Finland
Laparoscopy
4.4
7.2
25
61
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.3
6.8
33
107
K35.9
ICD-10 Finland
Acute appendicitis, unspecified
3.5
6.8
31
96
C18.10
ICD-10 Finland
Malignant tumor of the appendix without histology
23.1
6.7
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
6.6
156
1087
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
7.1
6.6
15
22
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
6.4
57
266
P01AB01
ATC
metronidazole; oral, rectal
1.9
6.4
133
885
K38.9
ICD-10 Finland
Disease of appendix, unspecified
+∞
6.3
6
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.5
6.2
49
218
D12.9
ICD-10 Finland
Benign neoplasm: Anus and anal canal
12.9
6.1
10
8
D37.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Colon
6.9
6.1
14
21

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
119
349
4.59
37.92
1.5
1.3
—
—
—
0
0
122
366
4.52
37.72
3.7
4.1
3.9
41.0
ug/l
1.07
100
312
212
1330
2.43
15.16
5.8
4.5
34.7
35.4
g/l
1.05
202
1243
168
982
2.33
13.72
6.6
5.4
—
—
—
0
0
207
1383
2.16
11.51
4.7
4.1
—
—
—
0
0
159
960
2.17
11.48
3.0
2.4
—
—
—
0
0
44
145
3.32
11.05
3.3
2.9
80.3
2145.6
u/ml
1.00
37
122
13
14
9.59
10.82
2.3
3.3
56.2
63.4
nmol/l
0.36
13
14
94
471
2.35
10.55
2.5
2.4
2.4
2.3
g/l
1.13
89
427
67
288
2.63
10.45
2.8
2.3
32.1
32.3
u/l
0.02
56
238
185
1218
2.06
10.31
2.5
2.2
—
—
—
0
0
99
512
2.29
10.30
2.5
2.4
12.2
12.8
umol/l
0.43
93
465
229
1635
2.09
10.16
7.8
6.0
12.3
11.2
umol/l
0.77
222
1538
19
35
5.67
10.03
1.9
2.5
2.1
7.6
nmol/l
0.64
19
35
297
2373
2.40
9.54
10.3
7.3
79.4
78.3
u/l
0.21
285
2192
197
1353
2.00
9.48
7.0
5.6
0.6
0.7
%
0.41
187
1257
202
1400
2.00
9.47
7.2
5.9
8.9
8.7
%
0.46
194
1310
204
1419
2.00
9.46
7.1
5.7
26.2
27.3
%
0.69
193
1316
201
1393
2.00
9.40
7.1
5.6
2.9
2.8
%
0.01
193
1294
87
446
2.25
9.14
2.6
2.5
20.7
22.1
%
0.44
79
381
283
2238
2.21
8.97
4.8
4.2
13.4
12.9
mm/h
0.23
259
2028
78
385
2.31
8.95
1.3
1.3
—
—
—
0
0
73
351
2.35
8.89
3.4
2.6
6.1
8.4
umol/l
1.10
63
304
200
1408
1.94
8.68
6.9
5.5
58.7
57.4
%
0.74
188
1314
234
1743
1.97
8.51
11.9
8.9
4.4
4.1
e9/l
0.78
198
1537
82
424
2.21
8.38
1.4
1.2
—
—
—
0
0
211
1534
1.90
8.08
8.0
6.7
1.2
1.2
mmol/l
1.76
186
1297
205
1496
1.85
7.56
7.2
5.4
0.0
0.0
e9/l
0.22
170
1285
178
1248
1.84
7.43
3.3
2.7
135.8
128.7
ug/l
0.16
171
1140
209
1540
1.85
7.42
7.4
5.7
0.2
0.2
e9/l
0.03
179
1350
185
1316
1.83
7.33
11.9
9.6
0.0
0.0
e9/l
0.29
146
1078
203
1487
1.83
7.30
7.2
5.4
0.6
0.6
e9/l
0.41
169
1276
15
30
5.17
7.25
1.0
1.1
—
—
—
0
0
122
767
1.89
7.14
2.9
2.1
2.8
3.1
mg/l
1.32
110
652
132
852
1.86
7.11
5.2
4.1
—
—
—
0
0
234
1801
1.85
7.05
6.2
4.6
6.6
6.7
mmol/l
0.58
222
1690
205
1519
1.81
6.97
7.3
5.5
1.7
1.9
e9/l
1.73
172
1333
335
2946
2.84
6.80
23.2
14.9
27.5
24.0
mg/l
1.02
288
2359
194
1421
1.79
6.80
6.8
5.6
1.2
1.2
mmol/l
2.45
181
1275
179
1290
1.77
6.55
10.8
9.8
1.3
1.3
inr
0.24
51
366
101
613
1.90
6.50
4.0
3.9
68.1
196.9
ng/l
1.36
89
500
140
968
1.73
5.73
3.3
3.2
—
—
—
0
0
175
1287
1.70
5.71
2.2
2.0
92.2
94.3
pmol/l
0.22
89
676
54
276
2.12
5.58
2.3
2.3
0.2
0.2
g/l
0.30
49
254
138
960
1.71
5.47
3.1
2.5
58.5
55.9
u/l
0.49
133
880
33
141
2.47
5.16
4.1
3.6
23.9
24.4
mmol/l
0.46
27
128
75
444
1.87
5.11
2.4
1.8
—
—
—
0
0
120
820
1.69
5.00
3.8
3.2
—
—
—
0
0
134
945
1.66
4.95
4.3
3.4
15.2
113.0
e6/l
0.83
104
735
95
613
1.75
4.86
3.8
3.0
2.5
2.5
mmol/l
0.00
79
542
283
2426
1.76
4.73
29.3
18.5
14.1
13.8
%
1.99
278
2387
343
3146
2.72
4.65
14.7
10.7
25.1
25.2
u/l
0.05
337
3020
95
622
1.71
4.59
3.7
3.1
528.0
548.9
mosm/kgh2o
0.39
80
530
342
3136
2.64
4.57
26.9
17.7
82.6
79.0
umol/l
0.86
342
3136
123
865
1.64
4.52
4.0
3.3
1.3
0.5
e6/l
0.49
94
651
111
764
1.65
4.42
8.8
6.6
—
—
—
0
0
147
1085
1.60
4.41
5.3
3.9
26.0
91.8
e6/l
3.10
109
786
50
275
1.95
4.23
3.9
3.6
1.3
2.1
mmol/l
0.77
37
222
48
262
1.96
4.15
8.9
6.3
1.2
1.3
mmol/l
0.37
43
246
64
386
1.80
4.08
2.2
2.6
1.7
1.8
%
0.21
58
349
50
279
1.92
4.06
3.9
3.6
6.0
5.8
kpa
0.63
44
268
348
3242
2.90
4.04
34.0
22.1
247.8
245.6
e9/l
0.22
340
3149
50
281
1.90
3.97
3.8
3.6
—
—
—
0
0
348
3245
2.87
3.97
34.0
22.1
6.7
6.7
e9/l
0.05
340
3143
348
3245
2.87
3.97
34.0
22.1
4.4
4.5
e12/l
1.40
339
3144
24
101
2.47
3.90
2.2
2.2
289.7
333.2
ug/l
0.13
24
93
297
2627
1.73
3.89
26.1
16.0
38.9
39.8
%
1.01
218
1804
50
284
1.88
3.85
1.4
1.4
—
—
—
0
0
142
1068
1.54
3.80
4.0
3.3
2.3
2.4
mmol/l
1.36
119
928
130
961
1.55
3.75
4.5
3.9
7.4
7.4
ph
0.10
21
172
241
2037
1.55
3.70
6.0
4.5
—
—
—
0
0
253
2165
1.56
3.65
4.9
4.1
—
—
—
0
0
15
51
3.03
3.62
1.1
1.2
11.0
8.1
u/l
—
9
41
56
337
1.78
3.59
2.1
1.5
—
—
—
0
0
61
379
1.73
3.50
9.5
6.4
104.5
103.8
mmol/l
0.64
61
369
75
495
1.65
3.45
4.1
3.2
0.8
0.8
mmol/l
0.65
66
461
10
27
3.78
3.37
1.1
1.1
—
—
—
0
0
330
3046
1.94
3.28
22.6
14.2
—
—
—
0
0
92
650
1.56
3.18
1.9
1.7
1.3
1.3
mg/l
0.02
75
506
86
600
1.57
3.14
3.5
3.0
0.8
0.8
ug/l
0.12
64
398
12
39
3.15
3.12
1.1
1.0
—
—
—
0
0
12
39
3.15
3.12
2.4
1.3
—
—
—
0
0
54
346
1.66
2.78
8.9
7.3
0.8
1.3
mmol/l
0.48
39
283
91
660
1.51
2.76
3.1
2.8
3.8
4.5
e6/l
0.46
76
583
59
391
1.61
2.66
1.4
1.3
547.7
475.6
titre
0.14
13
101
151
1218
1.41
2.60
4.1
3.9
31.0
66.6
ng/l
0.70
106
896
53
344
1.63
2.60
9.1
7.2
13.2
12.0
kpa
0.76
48
334
53
344
1.63
2.60
9.1
7.2
5.3
5.1
kpa
0.63
48
332
300
2740
1.55
2.57
5.2
4.8
2.0
2.0
mu/l
0.07
284
2456
97
729
1.45
2.44
1.3
1.3
—
—
—
0
0
72
512
1.51
2.38
1.2
1.3
17.8
36.6
iu/ml
2.31
23
172
64
444
1.54
2.38
39.1
23.1
1.4
1.3
inr
—
5
63
26
142
1.90
2.30
1.4
2.1
1.5
1.6
g/l
0.18
20
127
37
228
1.69
2.22
1.8
2.4
—
—
—
0
0
10
36
2.83
2.22
1.3
1.6
—
—
—
0
0
10
36
2.83
2.22
1.2
1.3
—
—
—
0
0
21
108
2.00
2.20
2.8
1.8
—
—
—
0
0
39
245
1.66
2.18
12.4
7.5
—
—
—
0
0
174
1469
1.36
2.16
5.8
5.2
0.0
0.0
estimate
0.00
36
268
305
2827
1.50
2.11
6.7
6.3
39.7
40.4
mmol/mol
0.63
292
2611
27
156
1.79
2.03
13.4
8.8
24.4
24.6
mmol/l
0.09
22
149
23
128
1.85
1.95
1.9
3.1
—
—
—
0
0
89
687
1.39
1.90
3.7
3.7
—
—
—
0
0
41
271
1.58
1.89
2.2
2.7
15.0
7.9
ug/l
0.36
34
238
171
1462
1.32
1.87
4.2
3.9
0.0
0.0
estimate
0.00
35
273
74
556
1.42
1.85
1.5
1.4
2.6
2.6
g/l
0.05
46
320
39
257
1.58
1.83
1.5
1.5
—
—
—
0
0
26
156
1.72
1.74
12.2
9.3
—
—
—
0
0
31
196
1.64
1.72
2.8
2.2
9.7
12.8
nmol/l
1.56
26
177
5
13
3.88
1.72
1.4
1.4
1.0
1.0
g/l
—
5
13
83
644
1.37
1.72
1.8
1.7
1019.2
1186.8
nmol/l
0.84
63
490
172
1485
1.30
1.71
4.3
3.9
0.0
0.0
estimate
0.50
36
261
8
31
2.62
1.67
3.9
3.1
—
—
—
0
0
8
31
2.62
1.67
1.3
1.2
—
—
—
0
0
10
43
2.36
1.61
1.6
1.5
—
—
—
0
0
10
43
2.36
1.61
1.4
1.1
—
—
—
0
0
100
807
1.33
1.60
3.2
2.7
373.6
7191.2
umol/l
3.46
91
690
8
33
2.46
1.54
1.5
1.2
—
—
—
0
0
316
2994
1.44
1.50
5.5
5.3
2.6
2.7
mmol/l
0.96
296
2719
64
487
1.38
1.49
1.2
1.3
21.4
12.2
u/ml
0.34
19
189
15
80
1.91
1.47
4.4
2.7
1.6
1.7
mg/l
0.22
15
72
308
2908
1.40
1.47
4.6
4.7
1.4
1.5
mmol/l
0.84
293
2646
27
173
1.61
1.45
1.3
1.4
—
—
—
0
0
44
316
1.45
1.42
2.1
2.1
165.0
156.2
ug/g
0.03
36
249
7
29
2.44
1.40
1.0
1.6
—
—
—
0
0
9
41
2.22
1.38
1.2
1.3
34.3
33.2
g/l
—
9
36
6
23
2.63
1.37
2.0
1.2
—
—
—
0
0
29
192
1.55
1.37
1.6
1.6
0.8
1.4
g/l
1.93
29
172
308
2919
1.37
1.33
4.8
4.9
6.1
6.0
mmol/l
0.16
288
2640
14
76
1.88
1.31
1.4
1.2
—
—
—
0
0
32
219
1.51
1.31
1.7
1.4
—
—
—
0
0
93
764
1.29
1.30
1.8
1.6
19.1
20.9
nmol/l
0.76
82
644
122
1038
1.26
1.29
6.3
5.2
2.5
2.9
ug/l
0.26
108
921
5
18
2.80
1.29
3.2
1.6
—
—
—
0
0
11
55
2.03
1.28
1.7
1.6
—
—
—
0
0
14
77
1.85
1.27
1.2
1.1
—
—
—
0
0
49
367
1.39
1.27
1.6
1.4
—
—
—
0
0
42
307
1.42
1.25
1.5
1.4
—
—
—
0
0
16
93
1.75
1.23
4.5
3.2
—
—
—
0
0
28
189
1.52
1.23
1.5
1.3
—
—
—
0
0
38
274
1.43
1.22
1.4
1.4
—
—
—
0
0
308
2929
1.35
1.21
4.7
4.7
4.5
4.6
mmol/l
0.79
291
2687
39
284
1.42
1.19
2.3
2.7
71.7
69.5
e9/l
0.15
26
231
115
981
1.25
1.18
3.9
4.1
11.8
9.9
mg/mmol
0.14
68
609
112
953
1.25
1.17
3.1
3.2
7.6
7.3
mmol/l
0.38
87
784
12
65
1.88
1.14
2.0
2.4
—
—
—
0
0
14
80
1.78
1.14
1.1
1.1
—
—
—
0
0
111
949
1.24
1.11
4.2
4.1
—
—
—
0
0
8
148
0.53
1.06
2.8
3.6
—
—
—
0
0
76
626
1.27
1.04
1.4
1.2
1.9
1.4
u/ml
0.25
14
158
296
2816
1.28
1.03
4.1
4.2
1.3
1.3
mmol/l
0.56
275
2544
14
84
1.69
0.99
5.1
2.9
101.9
81.4
ug/min
—
8
50
16
100
1.63
0.98
1.4
1.2
—
—
—
0
0
0
29
0.00
0.98
0.0
1.1
—
—
—
0
0
29
208
1.43
0.98
3.4
4.8
—
—
—
0
0
7
36
1.96
0.97
1.6
1.6
15.3
16.9
ug/l
—
7
36
25
175
1.46
0.96
1.2
1.2
172.8
132.6
iu/ml
—
10
69
22
150
1.50
0.95
1.3
1.2
—
—
—
0
0
11
62
1.80
0.95
1.3
1.2
—
—
—
0
0
107
927
1.22
0.94
3.1
3.2
53.6
191.1
mg/l
0.78
64
593
6
28
2.16
0.92
1.0
2.1
—
—
—
0
0
48
380
1.30
0.90
1.5
1.5
—
—
—
0
0
15
96
1.59
0.85
1.0
1.1
—
—
—
0
0
14
88
1.61
0.85
4.8
7.5
1.2
1.2
mmol/l
0.12
14
78
25
181
1.41
0.82
1.2
1.2
—
—
—
0
0
93
805
1.21
0.82
1.5
1.6
1.3
1.3
mmol/l
0.02
81
666
16
107
1.52
0.77
1.9
3.2
0.4
0.2
g/l
—
7
34
28
210
1.36
0.76
1.2
1.2
—
—
—
0
0
14
91
1.56
0.76
1.3
1.4
209.0
278.9
ug/g
—
6
53
5
26
1.94
0.71
1.0
1.2
—
—
—
0
0
5
26
1.94
0.71
2.2
2.3
—
—
—
0
0
23
170
1.38
0.69
3.0
2.5
—
—
—
0
0
7
42
1.68
0.68
1.0
1.6
32.0
32.6
pg
—
7
42
10
64
1.58
0.59
2.8
3.4
—
—
—
0
0
16
115
1.41
0.57
4.1
4.4
—
—
—
0
0
20
150
1.35
0.57
4.1
4.4
—
—
—
0
0
9
61
1.49
0.54
3.2
2.2
—
—
—
0
0
6
39
1.55
0.53
1.2
1.2
—
—
—
0
0
30
243
1.26
0.51
5.7
4.2
—
—
—
0
0
24
190
1.28
0.49
3.1
2.7
—
—
—
0
0
7
45
1.57
0.49
2.1
3.2
—
—
—
0
0
13
95
1.38
0.44
2.5
4.1
3.8
4.0
mmol/l
0.53
13
88
234
2247
1.12
0.44
4.4
4.0
14.8
14.8
pmol/l
0.22
222
2003
88
800
1.13
0.43
4.7
4.2
0.0
0.0
estimate
0.00
36
262
72
647
1.14
0.42
4.1
4.2
1.0
1.0
kg/l
0.41
13
89
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
5
35
1.43
0.39
2.0
1.9
86.1
90.1
%
—
5
35
5
36
1.39
0.38
1.0
1.2
—
—
—
0
0
9
67
1.35
0.38
1.1
1.2
—
—
—
0
0
107
996
1.11
0.35
2.8
3.1
—
—
—
0
0
11
145
0.75
0.35
1.5
1.5
—
—
—
0
0
6
43
1.40
0.35
5.5
2.4
3.4
4.8
e9/l
—
6
43
6
43
1.40
0.35
3.5
2.6
—
—
—
0
0
6
44
1.37
0.34
5.3
2.9
58.2
59.3
%
—
6
44
28
238
1.19
0.33
4.2
4.5
0.0
0.2
%
—
6
80
6
87
0.68
0.33
1.3
1.3
—
—
—
0
0
6
46
1.31
0.33
1.7
1.4
—
—
—
0
0
71
650
1.11
0.32
3.6
4.7
—
—
—
0
0
7
56
1.25
0.29
1.7
1.2
3.0
4.0
mmol/l
—
7
50
8
109
0.73
0.29
1.0
1.1
—
—
—
0
0
7
57
1.23
0.29
1.1
1.5
—
—
—
0
0
72
665
1.10
0.28
1.4
1.8
438.8
445.2
pmol/l
0.07
62
545
13
105
1.25
0.25
1.1
1.0
—
—
—
0
0
9
76
1.19
0.25
1.1
1.9
—
—
—
0
0
5
38
1.32
0.23
1.2
1.2
—
—
—
0
0
5
38
1.32
0.23
1.2
1.1
—
—
—
0
0
5
39
1.29
0.23
1.2
1.2
—
—
nmol/l
—
0
0
11
88
1.26
0.23
4.3
5.4
—
—
—
0
0
5
41
1.22
0.22
1.2
1.2
—
—
—
0
0
29
258
1.13
0.22
4.2
4.3
0.7
0.8
%
—
6
86
16
135
1.19
0.22
1.3
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
16.6
—
0
11
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
7.7
—
0.7
—
0
12
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
18
207
0.86
0.19
1.5
1.4
—
—
—
0
0
6
51
1.18
0.19
1.8
1.3
—
—
—
0
0
6
51
1.18
0.19
1.0
1.8
—
—
—
0
0
6
52
1.16
0.19
1.2
1.8
66.4
57.9
%
—
6
52
7
62
1.13
0.17
1.6
1.3
43.4
62.4
mmol/l
—
7
57
7
62
1.13
0.17
4.0
2.7
—
—
—
0
0
18
159
1.14
0.15
1.3
1.3
—
—
—
0
0
12
105
1.15
0.11
1.4
1.2
—
2.1
—
0
9
11
96
1.15
0.10
1.7
1.6
—
—
—
0
0
5
44
1.14
0.10
1.2
1.2
0.6
0.5
nmol/l
—
5
39
32
301
1.07
0.09
3.4
4.4
—
—
—
0
0
6
57
1.05
0.08
1.8
1.4
39.5
163.6
e6/l
—
6
47
6
57
1.05
0.08
1.8
1.3
18.7
7.8
e6/l
—
6
46
26
277
0.93
0.08
3.2
1.9
352.7
382.8
nmol/l
0.45
26
251
5
60
0.83
0.08
2.4
3.3
—
—
—
0
0
25
266
0.94
0.08
3.8
3.3
—
—
—
0
0
8
75
1.07
0.07
2.5
4.0
—
—
—
0
0
29
305
0.95
0.06
1.5
1.6
—
—
—
0
0
12
109
1.10
0.06
1.2
1.8
—
—
—
0
0
10
94
1.07
0.01
4.4
10.6
—
—
—
0
0
81
816
0.99
0.00
4.5
3.6
—
—
—
0
0
0
9
0.00
0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
3.9
—
0
9
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
6
64
0.94
0.00
1.8
1.2
423.8
497.5
mg/l
—
6
59
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
6
59
1.02
0.00
1.2
1.2
76.8
16.7
u/l
—
6
49
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
18.3
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
1.9
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_APPENDIX and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_APPENDIX 1.145 [0.93, 1.41] 0.206
Birth year 0.999 [0.99, 1.01] 0.73

During the follow-up period (1.1.1998 — 31.12.2019), 186 out of 979 females with CD2_BENIGN_APPENDIX died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_APPENDIX 1.264 [1.04, 1.54] 0.019
Birth year 0.984 [0.97, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 219 out of 743 males with CD2_BENIGN_APPENDIX died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_APPENDIX.

N-year risk Females Males
1 0.116% 0.274%
5 0.71% 1.536%
10 1.883% 3.573%
15 3.424% 6.429%
20 5.936% 10.78%

Relationships between endpoints

Index endpoint: CD2_BENIGN_APPENDIX – Benign neoplasm: Appendix

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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