Other benign neoplasm of uterus: Cervix uteri

CD2_BENIGN_CERVIX_UTERI

cervical carcinoma: A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D26.0&
  • Hospital discharge: ICD-9 2190
  • Cause of death: ICD-10 D26.0&
  • Cause of death: ICD-9 2190

2 out of 7 registries used, show all original rules.

214

4. Check minimum number of events

None

214

5. Include endpoints

None

214

6. Filter based on genotype QC (FinnGen only)

214

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D26
Name in latin
Neoplasma benignum cervicis uteri

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1668 1668 -
Only index persons 1538 1538 -
Unadjusted period prevalence (%)
Whole population 0.05 0.05 -
Only index persons 0.06 0.06 -
Median age at first event (years)
Whole population - 47.87 -
Only index persons - 47.37 -

-FinnGen-

Key figures

All Female Male
Number of individuals 214 214 -
Unadjusted period prevalence (%) 0.07 0.07 -
Median age at first event (years) 47.37 47.37 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
185
Matched controls
1850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D26.0
ICD-10 Finland
Other benign neoplasm: Cervix uteri
+∞
171.7
137
*
2190A
ICD-9 Finland
Other benign neoplasm of uterus, Cervix uteri
+∞
51.5
47
*
LDB00
NOMESCO Finland
Excision of lesion of cervix uteri
15.7
16.1
26
19
N84.1
ICD-10 Finland
Polyp of cervix uteri
8.9
11.8
25
32
8113
FHL
Fractional scraping
4.0
8.7
36
106
8111
FHL
Taking a biopsy from the mouth of the uterus at the operating room or under anesthesia (vulvabiopsia 8474, vaginabiopsia 8411)
41.6
6.8
8
*
LCA06
NOMESCO Finland
Biopsy of endometrium
2.7
6.1
44
192

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
36
177
2.24
4.26
2.6
3.2
19.3
35.7
u/ml
1.10
36
170
19
98
2.03
2.02
2.5
2.4
—
—
—
0
0
161
1429
1.51
1.84
7.4
7.1
80.6
76.5
u/l
0.27
150
1328
0
47
0.00
1.73
0.0
1.3
—
—
—
0
0
50
361
1.50
1.66
1.8
1.6
512195564.6
17123752.2
pmol/l
0.69
41
292
193
1806
1.70
1.51
4.8
4.3
5.8
5.8
mmol/l
0.09
180
1657
23
141
1.71
1.49
1.2
1.4
—
—
—
0
0
57
434
1.43
1.44
3.8
3.6
—
—
—
0
0
6
23
2.65
1.37
1.5
1.1
—
—
—
0
0
75
610
1.35
1.27
3.2
2.8
—
—
—
0
0
70
564
1.36
1.26
2.4
2.2
52.9
56.4
u/l
0.64
65
521
6
25
2.44
1.25
1.2
1.1
—
—
—
0
0
170
1566
1.42
1.24
4.8
4.4
14.7
14.6
pmol/l
0.09
158
1442
12
64
1.93
1.20
1.3
1.5
288.8
281.8
mu/l
0.05
12
58
51
395
1.38
1.16
5.5
3.6
—
—
—
0
0
80
668
1.32
1.12
3.7
3.1
2.4
2.4
mmol/l
0.31
68
589
34
247
1.45
1.10
1.3
1.2
—
—
—
0
0
16
97
1.70
1.10
4.3
4.2
—
—
—
0
0
22
147
1.55
1.05
1.3
1.2
—
—
—
0
0
5
22
2.30
1.04
1.0
1.1
—
—
—
0
0
181
1701
1.42
1.04
6.3
5.2
39.1
38.8
mmol/mol
0.15
167
1583
22
148
1.54
1.03
3.4
2.8
—
—
—
0
0
7
35
2.03
1.01
2.9
2.4
—
—
—
0
0
55
444
1.32
0.96
1.7
1.7
1.0
0.9
mg/l
0.14
43
342
39
302
1.36
0.90
1.6
1.7
1286.2
1221.1
nmol/l
0.14
30
215
179
1692
1.35
0.87
16.4
13.3
38.4
39.5
%
0.78
127
1259
201
1939
1.60
0.86
15.3
11.7
—
—
—
0
0
111
994
1.24
0.83
5.4
5.6
9.3
9.7
umol/l
0.25
106
934
25
182
1.42
0.82
2.1
4.0
5.1
7.7
ug/l
0.30
19
148
96
847
1.24
0.82
2.3
2.1
—
—
—
0
0
20
140
1.47
0.80
1.2
1.3
28.1
28.9
iu/l
0.04
20
122
195
1874
1.46
0.80
4.7
4.7
2.9
2.9
mmol/l
0.02
180
1729
105
938
1.23
0.79
4.2
3.6
0.0
0.0
estimate
0.00
17
174
196
1887
1.46
0.77
15.0
13.4
139.7
139.7
mmol/l
0.05
189
1832
6
34
1.79
0.77
1.2
1.6
—
—
—
0
0
20
142
1.45
0.75
3.1
2.7
1.1
2.2
mmol/l
1.06
13
116
106
952
1.22
0.75
4.2
3.7
0.2
0.0
estimate
0.48
19
170
9
56
1.63
0.73
3.1
3.7
—
—
—
0
0
5
25
2.02
0.73
1.8
2.3
3.8
3.9
mmol/l
—
5
25
5
25
2.02
0.73
1.8
2.3
104.6
106.3
mmol/l
—
5
25
5
25
2.02
0.73
1.8
2.3
—
—
—
0
0
105
944
1.22
0.73
6.5
5.0
0.0
0.0
estimate
0.00
17
177
12
77
1.59
0.70
3.3
2.4
24.5
25.1
mmol/l
0.39
12
77
26
197
1.36
0.70
1.2
1.4
—
—
—
0
0
27
206
1.36
0.70
1.9
1.7
—
—
—
0
0
5
27
1.87
0.69
1.0
1.1
—
—
—
0
0
5
95
0.52
0.68
1.0
1.1
—
—
—
0
0
112
1020
1.21
0.66
4.2
3.9
6.5
6.5
mmol/l
0.01
101
939
5
29
1.74
0.64
1.4
1.1
—
—
—
0
0
23
295
0.75
0.59
1.3
1.2
—
—
—
0
0
59
511
1.21
0.58
3.5
3.7
1.5
6.1
mg/mmol
1.99
30
281
195
1890
1.36
0.58
15.1
13.5
4.0
3.9
mmol/l
0.60
188
1831
6
37
1.64
0.56
3.3
2.5
7.0
6.9
mmol/l
—
6
37
36
431
0.80
0.55
1.7
1.5
21.5
22.9
nmol/l
0.24
30
359
6
38
1.60
0.55
3.3
2.5
1.3
1.4
mmol/l
—
6
38
17
223
0.74
0.51
1.6
1.3
—
—
—
0
0
201
1962
1.40
0.51
11.1
10.1
24.1
23.6
u/l
0.20
192
1890
117
1087
1.17
0.51
8.0
8.8
3.8
3.9
e9/l
0.25
103
964
38
448
0.82
0.50
3.5
3.2
93.2
96.7
%
0.52
38
441
137
1290
1.17
0.49
3.6
3.5
—
—
—
0
0
29
351
0.80
0.49
2.4
2.4
7.8
8.6
e6/l
0.08
20
310
7
46
1.54
0.49
5.4
4.0
—
—
—
0
0
14
102
1.40
0.48
1.1
1.1
—
106.0
—
0
5
105
970
1.16
0.48
4.4
5.6
0.2
0.2
e9/l
0.04
95
866
15
111
1.38
0.48
3.6
5.6
—
—
—
0
0
22
174
1.29
0.47
1.3
1.3
—
—
—
0
0
98
903
1.16
0.46
3.3
2.8
85.2
78.2
ug/l
0.28
92
842
21
166
1.29
0.45
5.4
5.5
1.6
1.5
mmol/l
0.01
16
133
19
148
1.31
0.45
2.4
3.3
—
—
—
0
0
100
925
1.15
0.44
4.4
5.4
0.5
0.5
e9/l
0.45
90
820
13
96
1.38
0.42
5.5
3.1
—
—
—
0
0
5
32
1.58
0.42
2.0
1.3
—
—
—
0
0
100
929
1.14
0.41
4.4
5.4
0.0
0.0
e9/l
0.79
90
821
48
422
1.18
0.41
4.0
3.8
1.0
1.0
kg/l
—
7
54
0
18
0.00
0.40
0.0
2.3
—
—
—
0
0
50
442
1.17
0.40
3.0
2.0
2.8
3.3
mg/l
0.81
42
373
0
19
0.00
0.39
0.0
2.3
—
—
—
0
0
188
1832
1.22
0.37
4.3
4.2
1.6
1.6
mmol/l
0.15
178
1689
189
1844
1.21
0.35
4.4
4.2
4.8
4.9
mmol/l
0.13
180
1709
101
947
1.13
0.35
4.4
5.4
1.7
2.0
e9/l
1.52
90
850
12
91
1.34
0.34
3.3
1.8
—
—
—
0
0
180
1751
1.18
0.34
3.8
3.8
1.2
1.2
mmol/l
0.22
166
1608
6
47
1.28
0.32
4.2
2.3
—
—
—
0
0
16
129
1.26
0.31
4.9
2.7
—
—
—
0
0
18
148
1.24
0.30
1.9
1.5
—
—
—
0
0
90
844
1.11
0.30
4.9
4.8
1.2
1.2
mmol/l
0.11
77
764
72
667
1.12
0.30
3.1
2.8
—
—
—
0
0
7
57
1.24
0.29
1.0
1.2
—
—
—
0
0
43
477
0.88
0.29
3.3
2.7
—
—
—
0
0
53
483
1.13
0.28
3.1
2.9
9.2
176.3
mg/l
0.58
24
275
11
85
1.31
0.28
1.0
1.3
—
—
—
0
0
59
638
0.90
0.26
4.2
3.5
15.1
75.3
e6/l
3.49
38
424
5
71
0.70
0.26
1.6
1.2
—
—
—
0
0
64
594
1.11
0.25
5.2
5.4
—
—
—
0
0
14
169
0.82
0.25
1.0
1.2
244.2
177.6
iu/ml
—
7
77
89
842
1.10
0.24
4.9
5.5
0.6
0.7
%
1.12
84
780
44
401
1.12
0.24
1.4
1.3
1.0
9.6
u/ml
2.71
19
157
5
38
1.32
0.23
1.2
1.1
—
—
—
0
0
5
38
1.32
0.23
1.2
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
92.3
—
0
11
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
1.9
—
0
10
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
142.0
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
0.9
—
0
12
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
36
328
1.12
0.20
3.6
3.5
239.6
153.8
ng/l
0.18
23
230
6
51
1.18
0.19
5.0
3.4
3.9
3.8
mmol/l
—
6
46
20
175
1.16
0.19
1.2
1.4
—
—
—
0
0
6
52
1.16
0.19
1.5
1.2
—
—
—
0
0
20
227
0.87
0.19
1.3
1.3
—
—
—
0
0
19
166
1.16
0.18
3.2
4.2
—
—
—
0
0
56
526
1.09
0.18
2.8
2.8
7.0
6.9
mmol/l
0.05
43
431
127
1307
0.93
0.17
6.0
4.4
—
—
—
0
0
7
63
1.11
0.17
3.3
3.7
—
—
—
0
0
5
66
0.75
0.17
1.6
2.5
—
0.1
—
0
16
50
533
0.92
0.17
4.1
3.2
—
—
—
0
0
57
604
0.92
0.17
4.0
3.6
7.4
7.4
ph
—
8
111
10
83
1.21
0.15
1.9
2.0
1.1
1.1
%
—
10
83
15
171
0.87
0.15
1.3
1.1
—
—
—
0
0
61
579
1.07
0.15
2.0
2.2
—
—
—
0
0
55
520
1.08
0.15
3.1
2.9
9.0
50.2
e6/l
1.87
35
384
91
879
1.06
0.13
4.9
5.4
57.6
56.2
%
0.58
85
826
57
542
1.07
0.13
2.3
2.0
108.5
137.6
u/l
0.86
49
509
9
107
0.83
0.13
1.9
1.3
—
—
—
0
0
46
486
0.93
0.13
6.5
6.8
—
—
—
0
0
80
827
0.95
0.11
6.9
8.8
0.0
0.0
e9/l
1.06
66
690
90
874
1.05
0.10
5.4
5.7
8.3
8.2
%
0.02
85
819
31
330
0.93
0.10
2.0
1.8
—
—
—
0
0
12
135
0.88
0.10
1.1
1.8
—
—
—
0
0
183
1811
1.07
0.09
5.8
5.2
1.9
2.5
mu/l
0.39
169
1675
76
737
1.05
0.09
1.9
1.9
112.9
99.8
pmol/l
1.06
38
337
6
54
1.11
0.09
7.0
7.8
—
—
—
0
0
6
54
1.11
0.09
2.3
2.6
—
—
—
0
0
91
889
1.04
0.08
5.2
5.6
26.8
29.3
%
1.46
85
832
45
432
1.05
0.08
1.3
1.5
2.3
2.3
g/l
0.01
33
266
8
76
1.05
0.07
1.0
1.1
—
—
—
0
0
7
85
0.82
0.07
7.9
4.1
24.5
25.2
mmol/l
—
7
85
9
85
1.06
0.07
7.0
6.4
95.8
95.0
%
—
9
85
9
86
1.05
0.07
7.0
6.2
1.1
0.7
%
—
9
86
9
87
1.04
0.07
7.0
6.2
1.6
1.4
%
—
9
87
23
244
0.94
0.06
2.0
1.9
—
—
—
0
0
66
643
1.04
0.06
2.9
3.4
197.7
25.8
ng/l
0.48
37
420
63
647
0.96
0.06
9.4
6.8
1.2
1.1
inr
0.10
17
194
51
494
1.04
0.06
1.3
1.3
0.5
2.2
u/ml
1.11
17
139
41
395
1.05
0.06
1.3
1.3
16.1
36.8
iu/ml
1.89
12
139
13
121
1.08
0.04
2.8
2.4
117.5
150.2
ng/l
0.28
13
108
16
151
1.06
0.03
2.0
2.8
10.7
10.1
g/l
0.30
16
140
47
479
0.98
0.02
3.1
2.8
0.4
0.5
e6/l
0.05
29
347
53
522
1.02
0.01
1.6
1.6
1.5
1.3
mmol/l
0.60
48
440
50
506
0.98
0.00
3.5
3.9
0.0
0.0
estimate
0.00
19
178
19
186
1.02
0.00
4.6
4.7
106.3
103.7
mmol/l
1.79
19
181
14
139
1.01
0.00
1.4
1.4
—
—
—
0
0
23
226
1.02
0.00
3.7
2.2
20.0
22.1
%
0.34
18
189
15
151
0.99
0.00
3.7
3.7
—
—
—
0
0
16
161
0.99
0.00
2.7
2.4
—
22.4
—
0
5
19
191
0.99
0.00
2.5
1.5
—
—
—
0
0
50
497
1.01
0.00
4.6
3.5
—
—
—
0
0
45
445
1.01
0.00
2.7
4.7
—
—
—
0
0
144
1437
1.01
0.00
4.8
4.1
12.2
11.2
mm/h
0.50
132
1319
51
508
1.01
0.00
1.5
1.4
—
—
—
0
0
187
1868
1.01
0.00
15.6
12.3
20.2
19.6
mg/l
0.11
147
1425
29
288
1.01
0.00
1.7
1.6
—
—
—
0
0
21
208
1.01
0.00
1.6
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
0.00
5.8
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
19
190
1.00
0.00
1.6
1.6
—
—
—
0
0
8
88
0.91
0.00
1.4
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
6
69
0.87
0.00
1.2
2.3
20.0
20.9
s
—
6
62
12
120
1.00
0.00
1.2
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
3.9
—
44.1
—
0
7
0
9
0.00
0.00
0.0
1.0
—
32.6
—
0
9
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
2.4
—
8.1
—
0
9

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_CERVIX_UTERI and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_CERVIX_UTERI 1.246 [0.97, 1.6] 0.081
Birth year 0.996 [0.99, 1.0] 0.33

During the follow-up period (1.1.1998 — 31.12.2019), 75 out of 822 females with CD2_BENIGN_CERVIX_UTERI died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CERVIX_UTERI.

N-year risk Females Males
1 0.128% No data
5 0.776% No data
10 2.011% No data
15 3.774% No data
20 6.605% No data

Relationships between endpoints

Index endpoint: CD2_BENIGN_CERVIX_UTERI – Other benign neoplasm of uterus: Cervix uteri

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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