Other benign neoplasm of uterus: Cervix uteri

CD2_BENIGN_CERVIX_UTERI

cervical carcinoma: A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

only females

293218

2. Check conditions

None

293218

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D26.0&
  • Hospital discharge: ICD-9 2190
  • Cause of death: ICD-10 D26.0&
  • Cause of death: ICD-9 2190

2 out of 7 registries used, show all original rules.

229

4. Check minimum number of events

None

229

5. Include endpoints

None

229

6. Filter based on genotype QC (FinnGen only)

219

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D26
Name in latin
Neoplasma benignum cervicis uteri

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1668 1668 -
Only index persons 1538 1538 -
Unadjusted period prevalence (%)
Whole population 0.05 0.05 -
Only index persons 0.06 0.06 -
Median age at first event (years)
Whole population - 47.87 -
Only index persons - 47.37 -

-FinnGen-

Key figures

All Female Male
Number of individuals 219 219 -
Unadjusted period prevalence (%) 0.08 0.08 -
Median age at first event (years) 47.91 47.91 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
229
Matched controls
2290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D26.0
ICD-10 Finland
Other benign neoplasm: Cervix uteri
+∞
224.6
177
*
2190A
ICD-9 Finland
Other benign neoplasm of uterus, Cervix uteri
+∞
54.4
50
*
N84.1
ICD-10 Finland
Polyp of cervix uteri
11.2
29.3
33
34
LDB00
NOMESCO Finland
Excision of lesion of cervix uteri
27.3
25.7
35
15
8113
FHL
Fractional scraping
4.5
14.6
39
99
LCA06
NOMESCO Finland
Biopsy of endometrium
2.8
10.6
65
280
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.8
8.7
52
219
LCB25
NOMESCO Finland
Hysteroscopic excision of lesion
3.3
7.2
28
92
8111
FHL
Taking a biopsy from the mouth of the uterus at the operating room or under anesthesia (vulvabiopsia 8474, vaginabiopsia 8411)
41.3
6.8
8
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.0
6.2
106
686
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
2.3
6.0
52
259

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
37
195
2.07
3.65
2.5
3.0
19.25
34.21
u/ml
1.07
37
186
173
1518
1.57
2.25
7.3
7.0
80.17
75.91
u/l
0.31
162
1415
20
103
2.03
2.13
2.4
2.4
—
—
—
0
0
15
73
2.13
1.85
1.5
1.5
344.80
293.82
mu/l
0.42
15
66
0
48
0.00
1.72
0.0
1.3
—
—
—
0
0
24
143
1.76
1.69
1.3
1.4
—
—
—
0
0
52
381
1.47
1.59
1.8
1.6
488372533.44
16077632.90
pmol/l
0.69
43
311
16
86
1.93
1.54
2.3
1.6
723.29
1259.81
u/l
—
7
29
205
1921
1.64
1.49
4.8
4.3
5.83
5.79
mmol/l
0.23
191
1767
81
652
1.37
1.46
3.1
2.8
—
—
—
0
0
38
267
1.51
1.42
1.3
1.2
—
—
—
0
0
6
23
2.65
1.37
1.5
1.1
—
—
—
0
0
17
98
1.79
1.35
4.1
4.2
—
—
—
0
0
5
18
2.82
1.29
1.2
1.2
—
—
—
0
0
59
460
1.38
1.28
3.8
3.5
—
—
—
0
0
6
26
2.34
1.19
1.2
1.1
—
—
—
0
0
180
1665
1.38
1.19
4.9
4.4
14.60
14.59
pmol/l
0.02
168
1537
23
151
1.58
1.17
3.3
2.8
—
—
—
0
0
38
279
1.43
1.16
2.6
2.6
5.02
4.01
e6/l
0.16
21
140
73
598
1.32
1.15
2.6
2.2
52.31
58.51
u/l
1.07
68
551
94
799
1.30
1.13
5.3
3.9
36.35
36.24
g/l
0.08
89
746
193
1811
1.42
1.12
6.2
5.3
38.94
38.85
mmol/mol
0.06
179
1686
114
1001
1.28
1.04
4.2
3.6
0.00
0.00
estimate
-0.00
21
196
9
47
1.95
1.03
4.8
4.0
—
—
—
0
0
118
1043
1.27
1.02
5.6
5.5
9.31
9.71
umol/l
0.26
113
982
114
1005
1.27
1.00
6.4
4.9
0.00
0.00
estimate
-0.00
18
185
115
1015
1.27
1.00
4.2
3.6
0.15
0.00
estimate
0.48
20
178
210
2011
1.53
0.99
14.6
13.3
139.66
139.75
mmol/l
0.21
203
1954
7
36
1.97
0.98
2.9
2.4
—
—
—
0
0
145
1319
1.27
0.96
3.5
2.8
44.28
39.46
u/l
0.29
134
1235
83
708
1.27
0.94
3.8
3.1
2.37
2.36
mmol/l
0.15
71
631
215
2073
1.61
0.93
15.2
11.5
—
—
—
0
0
6
28
2.17
0.92
1.0
1.1
—
—
—
0
0
52
419
1.31
0.91
5.4
3.6
—
—
—
0
0
13
79
1.68
0.90
3.2
2.6
24.51
25.15
mmol/l
0.47
13
79
21
145
1.49
0.88
3.1
2.8
1.14
2.10
mmol/l
1.04
14
123
23
163
1.46
0.86
1.3
1.2
—
—
—
0
0
120
1078
1.24
0.85
4.2
4.0
6.47
6.44
mmol/l
0.04
109
992
22
155
1.46
0.85
1.2
1.3
25.94
30.48
iu/l
0.27
22
134
148
1361
1.25
0.84
3.6
3.4
—
—
—
0
0
103
912
1.24
0.83
2.2
2.1
—
—
—
0
0
54
445
1.28
0.80
3.8
3.8
1.01
1.02
kg/l
—
7
56
15
100
1.54
0.75
5.1
3.0
—
—
—
0
0
6
106
0.55
0.74
1.0
1.1
—
—
—
0
0
29
221
1.36
0.74
1.8
1.7
—
—
—
0
0
7
38
1.87
0.74
3.3
2.5
6.81
6.86
mmol/l
—
7
38
56
469
1.26
0.73
1.7
1.7
0.98
0.87
mg/l
0.16
44
359
7
39
1.82
0.73
3.3
2.4
1.37
1.34
mmol/l
—
7
39
5
25
2.02
0.73
1.8
2.3
3.84
3.89
mmol/l
—
5
25
5
25
2.02
0.73
1.0
1.1
—
—
—
0
0
5
25
2.02
0.73
1.8
2.3
—
—
—
0
0
5
25
2.02
0.73
1.8
2.3
104.60
106.28
mmol/l
—
5
25
63
540
1.23
0.67
3.6
3.6
1.44
5.94
mg/mmol
2.12
32
301
92
822
1.20
0.65
3.6
3.3
5.63
6.00
ph
—
8
63
25
191
1.35
0.64
2.1
3.9
4.89
7.53
ug/l
0.33
20
153
39
318
1.27
0.64
1.6
1.7
1286.23
1230.94
nmol/l
0.12
30
229
207
2004
1.34
0.61
4.7
4.7
2.83
2.85
mmol/l
0.13
192
1856
208
2016
1.35
0.60
14.8
13.4
3.95
3.93
mmol/l
0.38
201
1953
215
2095
1.43
0.59
11.0
10.0
24.22
23.74
u/l
0.20
206
2022
6
35
1.73
0.58
1.2
1.6
—
—
—
0
0
18
238
0.74
0.56
1.6
1.3
—
—
—
0
0
9
62
1.47
0.54
3.1
3.7
—
—
—
0
0
6
39
1.55
0.53
1.2
1.2
6.78
19.44
u/l
—
6
27
25
312
0.78
0.53
1.2
1.2
—
—
—
0
0
31
376
0.80
0.52
2.4
2.5
6.94
8.54
e6/l
0.19
25
336
20
153
1.34
0.52
2.4
3.3
—
—
—
0
0
105
968
1.16
0.48
3.3
2.8
81.65
77.09
ug/l
0.18
99
903
124
1158
1.15
0.47
8.2
8.7
3.83
3.93
e9/l
0.23
109
1022
23
184
1.28
0.45
1.2
1.4
—
—
—
0
0
7
50
1.41
0.45
3.7
2.2
—
—
—
0
0
105
972
1.15
0.45
6.3
5.6
1.24
1.23
mmol/l
0.90
88
829
5
31
1.63
0.43
1.4
1.1
—
—
—
0
0
25
204
1.25
0.43
1.5
1.6
—
—
—
0
0
53
468
1.17
0.42
2.9
2.0
2.80
3.21
mg/l
0.74
45
397
39
450
0.84
0.41
1.7
1.5
21.29
22.65
nmol/l
0.27
33
375
42
481
0.84
0.41
3.4
3.2
92.05
97.03
%
0.88
42
472
0
17
0.00
0.41
0.0
2.6
—
0.82
—
0
9
5
34
1.48
0.40
2.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
2.3
—
—
—
0
0
17
133
1.30
0.40
5.2
2.7
—
—
—
0
0
111
1039
1.13
0.39
4.7
5.5
0.18
0.18
e9/l
0.06
101
926
24
198
1.24
0.38
1.3
1.3
—
—
—
0
0
15
116
1.31
0.38
3.5
6.1
—
—
—
0
0
63
569
1.15
0.38
2.3
2.0
104.02
135.54
u/l
1.07
55
535
106
992
1.13
0.37
4.7
5.3
0.53
0.54
e9/l
0.17
96
879
5
76
0.65
0.36
1.6
1.2
—
—
—
0
0
5
77
0.64
0.36
1.6
1.6
—
—
—
0
0
26
218
1.22
0.36
1.5
1.5
—
—
—
0
0
45
506
0.86
0.36
3.2
2.7
—
—
—
0
0
48
427
1.16
0.35
1.4
1.3
1.00
10.73
u/ml
3.07
20
164
106
995
1.12
0.35
4.7
5.3
0.04
0.04
e9/l
0.74
96
876
79
730
1.13
0.34
3.1
2.8
—
—
—
0
0
95
888
1.12
0.33
4.8
5.0
1.23
1.23
mmol/l
0.05
82
811
20
240
0.82
0.32
1.3
1.3
—
—
—
0
0
62
677
0.88
0.32
4.1
3.5
33.00
73.35
e6/l
0.95
40
447
26
221
1.20
0.32
1.2
1.4
—
—
—
0
0
15
186
0.79
0.32
1.3
1.1
—
—
—
0
0
35
306
1.17
0.32
1.7
1.6
—
—
—
0
0
40
354
1.16
0.32
1.8
1.8
—
—
—
0
0
99
931
1.11
0.31
5.3
6.0
—
—
—
0
0
14
111
1.28
0.31
1.1
1.1
—
106.00
—
0
5
56
511
1.13
0.29
2.9
3.0
8.60
164.93
mg/l
0.59
24
297
197
1927
1.16
0.29
5.9
5.2
1.94
2.44
mu/l
0.38
184
1784
12
94
1.29
0.28
3.3
1.8
—
—
—
0
0
8
63
1.28
0.28
3.0
3.7
—
—
—
0
0
107
1015
1.10
0.28
4.7
5.3
1.73
2.03
e9/l
1.53
97
916
200
1961
1.16
0.26
4.2
4.2
1.57
1.59
mmol/l
0.26
190
1813
201
1972
1.16
0.26
4.3
4.2
4.80
4.85
mmol/l
0.34
192
1834
95
899
1.10
0.25
5.2
5.4
0.61
0.73
%
1.39
89
832
17
142
1.21
0.25
2.2
4.4
0.86
0.77
%
—
7
41
11
88
1.26
0.23
1.0
1.3
—
—
—
0
0
19
163
1.18
0.22
1.9
1.5
—
—
—
0
0
5
41
1.22
0.22
1.4
1.8
—
—
—
0
0
5
42
1.19
0.21
1.2
1.1
—
—
—
0
0
5
42
1.19
0.21
1.2
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
8.42
—
0
10
0
10
0.00
0.21
0.0
1.8
—
142.00
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
31.20
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
0.90
—
0
12
5
43
1.17
0.21
2.0
1.6
19.72
32.70
u/l
—
5
36
84
797
1.09
0.21
17.2
10.0
1.22
1.15
inr
0.28
22
236
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
191
1876
1.11
0.19
3.8
3.7
1.26
1.23
mmol/l
0.28
177
1727
6
52
1.16
0.19
5.0
3.4
3.90
3.84
mmol/l
—
6
52
10
81
1.25
0.19
1.9
2.0
0.84
0.64
%
—
10
81
15
128
1.18
0.18
2.7
2.4
112.93
144.61
ng/l
0.31
15
115
48
515
0.91
0.18
6.6
6.8
—
—
—
0
0
18
157
1.16
0.18
1.9
2.8
10.89
10.08
g/l
0.54
18
146
7
62
1.13
0.17
1.0
1.2
—
—
—
0
0
71
674
1.08
0.17
3.3
3.4
179.25
25.90
ng/l
0.47
41
433
5
70
0.71
0.17
1.6
2.7
—
0.21
—
0
18
58
547
1.08
0.16
1.5
1.4
—
—
—
0
0
136
1396
0.94
0.16
5.8
4.3
—
—
—
0
0
16
181
0.88
0.15
1.1
1.2
215.04
170.91
iu/ml
—
8
82
59
560
1.07
0.14
2.7
2.8
7.08
6.88
mmol/l
0.11
46
466
10
84
1.20
0.14
1.9
2.0
1.12
1.06
%
—
10
84
45
423
1.08
0.14
1.3
1.3
15.68
35.90
iu/ml
2.01
13
146
10
117
0.85
0.13
1.8
1.3
—
—
—
0
0
97
939
1.06
0.13
5.2
5.3
57.45
56.37
%
0.42
92
881
58
553
1.07
0.12
3.0
2.9
9.91
48.47
e6/l
1.82
37
405
96
932
1.05
0.11
5.7
5.6
8.32
8.20
%
0.13
91
871
81
784
1.05
0.10
1.9
1.9
111.49
99.29
pmol/l
1.03
41
365
37
349
1.07
0.10
3.5
3.4
229.75
150.68
ng/l
0.17
24
243
14
126
1.12
0.09
1.1
1.4
—
—
—
0
0
6
54
1.11
0.09
1.7
1.1
—
—
—
0
0
6
55
1.09
0.09
2.3
2.5
—
—
—
0
0
19
175
1.09
0.08
3.2
4.1
—
—
—
0
0
90
878
1.04
0.08
7.0
8.6
0.00
0.00
e9/l
1.29
76
729
49
509
0.95
0.08
3.0
2.7
0.41
0.44
e6/l
0.08
31
366
97
949
1.04
0.07
5.5
5.5
26.76
29.17
%
1.51
92
893
6
75
0.79
0.07
1.2
2.2
20.00
21.00
s
—
6
68
8
91
0.87
0.07
1.4
1.3
—
—
—
0
0
24
254
0.94
0.06
2.0
1.9
—
—
—
0
0
151
1528
0.97
0.06
4.8
4.1
11.88
11.16
mm/h
0.35
139
1407
17
158
1.08
0.06
3.4
3.6
—
—
—
0
0
55
534
1.04
0.06
3.4
3.9
0.00
0.00
estimate
-0.00
20
186
16
172
0.92
0.06
2.7
2.3
—
21.30
—
0
6
14
151
0.92
0.05
1.1
1.7
—
—
—
0
0
17
159
1.07
0.05
2.4
4.4
0.71
0.67
%
—
7
53
62
635
0.97
0.05
3.9
3.8
7.40
7.40
ph
0.04
11
114
54
527
1.03
0.04
4.7
3.5
—
—
—
0
0
201
2000
1.04
0.03
15.0
12.2
19.49
19.51
mg/l
0.00
159
1525
52
531
0.97
0.03
1.3
1.3
0.51
2.05
u/ml
1.14
18
150
63
619
1.02
0.03
2.0
2.1
—
—
—
0
0
21
202
1.04
0.02
2.3
1.5
—
—
—
0
0
25
242
1.04
0.02
3.5
2.2
20.07
22.43
%
0.44
20
205
20
193
1.04
0.01
4.4
5.1
106.30
103.88
mmol/l
1.77
20
193
15
149
1.01
0.00
2.5
4.6
0.00
0.09
%
—
5
43
35
347
1.01
0.00
3.1
2.6
550.40
536.55
mosm/kgh2o
0.13
30
296
56
557
1.01
0.00
1.7
1.6
1.46
1.34
mmol/l
0.60
51
474
15
146
1.03
0.00
2.4
4.5
0.20
0.18
%
—
5
38
56
565
0.99
0.00
4.1
3.2
—
—
—
0
0
14
145
0.96
0.00
1.4
1.4
—
—
—
0
0
6
59
1.02
0.00
1.5
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
7.10
—
0
9
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
92
0.98
-0.00
7.0
6.7
1.58
1.38
%
—
9
92
9
91
0.99
-0.00
7.0
6.8
1.09
0.68
%
—
9
91
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
49
1.02
-0.00
1.0
1.1
3.34
3.87
mmol/l
—
5
41
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
-0.00
1.7
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.92
-0.00
1.0
1.2
553.60
360.21
mg/l
—
5
48
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
2.22
—
0
7
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
6
64
0.94
-0.00
1.8
1.2
—
—
—
0
0
5
56
0.89
-0.00
6.2
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
9
90
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
178.00
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
1.20
—
0
5
6
65
0.92
-0.00
1.7
1.2
—
—
—
0
0
6
64
0.94
-0.00
1.7
1.2
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.2
33.60
87.67
e6/l
—
5
42
9
89
1.01
-0.00
7.0
6.9
95.76
95.06
%
—
9
89
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
89
0.90
-0.00
7.3
4.8
24.16
25.15
mmol/l
—
8
89
0
8
0.00
-0.00
0.0
1.1
—
1415.13
—
0
8
0
8
0.00
-0.00
0.0
3.5
—
47.63
—
0
8
46
460
1.00
-0.00
1.3
1.5
2.24
2.27
g/l
0.05
34
280
6
62
0.97
-0.00
1.7
1.2
—
—
—
0
0
6
61
0.98
-0.00
7.0
7.2
—
—
—
0
0
5
57
0.87
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_CERVIX_UTERI and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_CERVIX_UTERI 1.246 [0.97, 1.6] 0.081
Birth year 0.996 [0.99, 1.0] 0.33

During the follow-up period (1.1.1998 — 31.12.2019), 75 out of 822 females with CD2_BENIGN_CERVIX_UTERI died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CERVIX_UTERI.

N-year risk Females Males
1 0.128% No data
5 0.776% No data
10 2.011% No data
15 3.774% No data
20 6.605% No data

Relationships between endpoints

Index endpoint: CD2_BENIGN_CERVIX_UTERI – Other benign neoplasm of uterus: Cervix uteri

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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