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Benign neoplasm: Connective and other soft tissue of thorax

MESH Endpoint Browser PheWeb

CD2_BENIGN_CONNSOFT_THX

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D21.3&
  • Hospital discharge: ICD-9 — 2154
  • Cause of death: ICD-10 — D21.3&
  • Cause of death: ICD-9 — 2154

2 out of 7 registries used, show all original rules.

155

4. Check minimum number of events

None

155

5. Include endpoints

None

155

6. Filter based on genotype QC (FinnGen only)

155

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D21
Name in latin
Neoplasma benignum textus connectivi/textus mollis thoracis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1115 664 446
Only index persons 1009 608 401
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 50.52 50.31 50.70
Only index persons 50.43 50.45 50.39

-FinnGen-

Key figures

All Female Male
Number of individuals 155 84 71
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 53.37 47.89 59.85

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
136
Matched controls
1359
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D21.3
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of thorax
+∞
169.6
125
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
15.5
22.6
38
33
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
25.8
10.5
14
6
R22.2
ICD-10 Finland
Localized swelling, mass and lump, trunk
12.8
9.9
17
15
GA1CG
NOMESCO Finland
Extensive MRI of chest
84.5
7.5
8
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
81
497
2.32
6.19
2.4
2.0
—
—
—
0
0
36
152
2.78
6.13
1.4
1.3
—
—
—
0
0
59
320
2.36
5.96
3.3
4.3
—
—
—
0
0
26
101
2.89
5.12
4.8
4.4
—
—
—
0
0
75
493
2.01
4.36
6.6
7.5
1.1
1.2
inr
0.87
22
148
112
852
2.13
4.30
4.1
4.0
—
—
—
0
0
100
732
2.03
4.24
4.1
4.5
6.7
6.6
mmol/l
0.14
95
676
81
552
1.98
4.20
5.2
5.2
1.2
1.2
mmol/l
0.34
76
498
25
112
2.47
3.72
1.4
1.3
—
—
—
0
0
145
1276
3.11
3.27
20.3
15.6
4.0
4.0
mmol/l
0.13
140
1238
55
356
1.84
3.13
2.6
2.9
0.1
0.4
e6/l
1.40
39
260
115
932
1.91
3.08
4.7
4.1
11.5
11.8
mm/h
0.11
103
851
54
353
1.81
2.95
2.8
2.8
—
—
—
0
0
7
13
5.58
2.90
4.3
3.4
—
—
—
0
0
39
231
1.92
2.89
1.9
1.6
1002.9
1169.5
nmol/l
0.62
27
178
58
390
1.78
2.88
2.8
3.1
11.8
204.1
e6/l
0.60
41
295
41
248
1.89
2.85
2.8
3.0
507.9
564.7
mosm/kgh2o
0.72
31
212
58
391
1.77
2.85
2.2
2.4
62.3
57.7
u/l
0.28
53
362
37
217
1.93
2.82
4.7
3.3
133.3
144.1
ng/l
0.04
29
159
52
345
1.76
2.67
4.7
3.8
—
—
—
0
0
83
633
1.67
2.53
5.9
5.5
1.7
1.8
e9/l
0.41
72
560
83
634
1.67
2.51
5.9
5.8
0.2
0.2
e9/l
0.86
72
560
12
47
2.68
2.33
1.8
3.4
—
—
—
0
0
47
314
1.71
2.32
3.1
2.6
314.5
2313.3
umol/l
0.81
37
267
80
615
1.62
2.29
5.9
5.5
0.0
0.0
e9/l
0.37
68
532
77
592
1.60
2.17
6.2
5.5
27.4
27.6
%
0.03
67
548
76
584
1.59
2.13
5.6
5.3
58.2
57.7
%
0.12
65
543
112
945
1.67
2.13
4.4
3.8
14.8
14.7
pmol/l
0.18
102
854
57
409
1.62
2.12
6.4
5.0
—
—
—
0
0
26
149
1.90
2.11
1.5
2.2
203.5
143.2
ug/g
0.27
18
111
73
557
1.59
2.10
6.3
5.4
0.7
0.6
%
0.25
64
513
18
90
2.13
2.10
4.4
4.3
0.0
0.2
%
—
6
27
79
615
1.58
2.08
6.0
5.5
0.6
0.6
e9/l
0.07
68
530
53
375
1.63
2.08
2.8
2.2
—
—
—
0
0
41
273
1.68
2.03
2.0
2.5
3.8
4.9
e6/l
0.27
31
240
19
99
2.05
2.01
4.2
4.1
0.5
1.2
%
—
6
32
74
573
1.56
1.97
6.1
5.4
3.1
2.8
%
0.61
65
530
5
11
4.66
1.95
1.4
1.5
—
—
—
0
0
27
161
1.82
1.94
19.9
22.8
1.4
1.4
inr
—
5
23
61
453
1.57
1.94
3.7
3.6
43.5
71.3
e6/l
0.40
41
322
144
1320
2.28
1.93
21.5
15.9
77.9
77.8
umol/l
0.02
144
1320
49
346
1.61
1.92
2.6
2.8
—
—
—
0
0
89
721
1.55
1.92
11.2
9.3
3.9
4.1
e9/l
0.41
78
625
84
672
1.55
1.91
8.3
6.2
16.6
11.1
umol/l
0.59
79
639
74
576
1.54
1.90
6.3
5.6
9.4
8.5
%
1.62
65
536
23
131
1.89
1.90
1.2
1.4
—
—
—
0
0
11
46
2.50
1.90
1.8
2.8
—
—
—
0
0
9
34
2.75
1.90
1.3
1.2
—
—
—
0
0
41
280
1.63
1.83
2.5
2.0
2.5
3.1
mg/l
2.13
36
241
144
1326
2.21
1.80
15.1
12.8
—
—
—
0
0
5
13
3.94
1.73
1.2
1.7
—
—
—
0
0
138
1257
1.89
1.71
19.1
13.9
20.4
23.3
mg/l
0.57
120
989
18
98
1.95
1.70
1.1
1.1
—
—
—
0
0
7
25
2.88
1.67
1.6
3.2
—
—
—
0
0
20
114
1.87
1.66
2.1
1.6
—
—
—
0
0
40
279
1.58
1.63
1.8
1.6
1.1
1.3
mg/l
0.26
34
223
5
14
3.65
1.63
1.4
3.3
—
—
—
0
0
74
596
1.46
1.52
4.7
5.1
0.0
0.0
estimate
0.00
18
115
74
596
1.46
1.52
3.8
3.6
0.0
0.0
estimate
0.00
18
117
18
104
1.83
1.44
2.9
2.4
0.2
0.2
g/l
0.07
18
96
74
603
1.43
1.40
3.8
3.7
0.0
0.0
estimate
0.00
17
109
16
90
1.87
1.39
5.6
2.3
8.2
9.9
g/l
1.04
16
81
45
334
1.49
1.38
1.5
1.4
—
—
—
0
0
6
23
2.67
1.38
1.0
1.0
—
—
—
0
0
6
23
2.67
1.38
1.3
1.3
—
—
—
0
0
69
557
1.43
1.37
10.4
9.6
0.0
0.0
e9/l
0.51
58
447
0
37
0.00
1.36
0.0
1.1
—
—
—
0
0
45
335
1.48
1.36
3.2
3.4
—
—
—
0
0
44
327
1.48
1.34
7.9
7.0
—
—
—
0
0
24
155
1.65
1.33
1.7
1.3
—
—
—
0
0
17
100
1.79
1.29
3.4
3.2
—
—
—
0
0
5
18
2.83
1.29
4.4
2.4
—
—
—
0
0
65
524
1.41
1.28
2.7
2.6
107.0
107.6
ug/l
0.01
60
482
6
25
2.45
1.25
1.0
1.2
—
—
—
0
0
44
332
1.45
1.23
4.0
3.7
0.0
0.0
estimate
0.00
17
111
126
1148
1.52
1.22
5.7
4.5
11.5
1.9
mu/l
0.50
117
1037
6
26
2.36
1.20
1.0
1.0
—
—
—
0
0
5
20
2.55
1.16
2.8
2.5
—
—
—
0
0
48
373
1.42
1.15
4.0
3.5
7.4
7.4
ph
0.03
13
66
38
283
1.45
1.14
1.4
1.2
0.8
1.3
u/ml
—
9
85
8
40
2.05
1.14
1.4
1.3
27.1
23.7
iu/l
—
8
33
35
257
1.47
1.12
1.8
1.8
428.5
453.0
pmol/l
0.26
30
215
12
66
1.89
1.12
1.1
1.2
—
—
—
0
0
14
82
1.78
1.09
2.9
1.9
—
—
—
0
0
59
479
1.37
1.09
2.3
1.9
90.1
93.3
pmol/l
0.23
25
239
7
34
2.11
1.04
2.6
5.8
—
—
—
0
0
9
47
1.97
1.04
2.0
1.6
—
—
—
0
0
5
22
2.31
1.04
1.0
1.1
—
—
—
0
0
5
22
2.31
1.04
1.0
1.1
—
—
—
0
0
35
263
1.43
1.00
2.1
1.3
1.6
2.4
g/l
2.54
21
155
59
487
1.34
0.96
4.5
4.0
38.5
34.5
ng/l
0.06
37
340
19
127
1.57
0.94
5.2
6.9
96.7
95.8
%
0.51
19
119
15
95
1.64
0.91
2.5
3.8
1.2
1.2
mmol/l
0.21
15
82
36
277
1.39
0.90
4.7
4.8
—
—
—
0
0
16
104
1.60
0.88
3.9
3.8
—
—
—
0
0
25
181
1.45
0.87
1.6
1.9
—
—
—
0
0
6
32
1.91
0.82
2.2
2.7
23.7
25.7
mmol/l
—
6
25
12
74
1.67
0.81
1.1
1.1
127.3
156.8
iu/ml
—
5
27
6
34
1.79
0.77
7.8
2.6
33.2
39.1
mg/l
—
6
29
6
34
1.79
0.77
7.8
2.6
49.0
29.3
mg/l
—
6
29
9
57
1.61
0.72
4.6
4.3
—
—
—
0
0
53
449
1.27
0.69
2.6
3.0
—
—
—
0
0
17
120
1.47
0.68
5.8
7.1
123.2
121.0
g/l
0.17
17
115
132
1251
1.37
0.67
5.4
4.9
2.8
2.8
mmol/l
0.30
125
1150
125
1177
1.32
0.65
4.5
3.9
1.3
1.3
mmol/l
0.49
118
1070
5
29
1.75
0.64
2.0
1.2
48.2
250.3
e6/l
—
5
20
5
29
1.75
0.64
2.0
1.1
2.2
14.2
e6/l
—
5
19
15
105
1.47
0.63
4.3
5.7
1.4
1.4
mmol/l
0.06
15
100
14
97
1.49
0.61
1.3
1.5
—
—
—
0
0
11
72
1.57
0.61
1.5
1.2
—
—
—
0
0
8
53
1.54
0.59
5.0
4.8
—
—
—
0
0
128
1214
1.31
0.59
4.8
4.4
6.0
5.9
mmol/l
0.53
117
1117
128
1215
1.31
0.58
4.9
4.3
1.5
1.5
mmol/l
0.24
120
1111
32
261
1.28
0.56
3.1
2.9
0.6
0.7
ug/l
0.46
19
174
122
1154
1.27
0.54
6.5
5.5
40.3
39.7
mmol/mol
0.33
111
1074
6
39
1.56
0.53
1.0
1.1
—
—
—
0
0
9
65
1.41
0.51
2.0
2.3
—
—
—
0
0
20
155
1.33
0.50
1.6
1.3
—
—
—
0
0
7
45
1.58
0.49
3.0
5.3
1.3
1.6
%
—
7
39
14
102
1.41
0.49
4.6
6.4
—
—
—
0
0
7
46
1.55
0.49
3.3
3.3
—
—
—
0
0
128
1223
1.27
0.48
4.8
4.4
4.7
4.7
mmol/l
0.13
120
1132
7
51
1.39
0.44
1.0
1.2
—
—
—
0
0
19
149
1.31
0.44
5.5
6.4
1.2
1.2
mmol/l
0.02
14
118
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.3
—
—
—
0
0
9
122
0.72
0.37
1.1
1.4
—
—
—
0
0
9
123
0.72
0.37
1.4
1.6
—
—
—
0
0
6
45
1.35
0.34
3.2
5.4
0.7
0.9
%
—
6
40
18
146
1.26
0.34
5.8
6.4
5.2
5.1
kpa
0.27
18
137
18
146
1.26
0.34
5.8
6.4
13.5
11.9
kpa
0.57
18
138
6
47
1.29
0.32
13.7
12.3
—
—
—
0
0
48
440
1.13
0.25
5.0
4.9
3.1
2.7
ug/l
0.12
39
386
5
40
1.26
0.22
2.0
1.6
—
—
—
0
0
15
126
1.21
0.22
1.5
1.4
—
—
—
0
0
12
98
1.24
0.22
1.5
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
38
349
1.12
0.19
4.3
3.9
3.2
7.9
mg/mmol
1.76
26
218
10
121
0.81
0.18
1.7
1.6
—
—
—
0
0
16
140
1.16
0.15
1.8
3.1
5.2
9.9
umol/l
1.17
16
126
30
277
1.10
0.14
4.2
3.4
—
—
—
0
0
90
873
1.07
0.13
4.3
3.8
—
—
—
0
0
10
85
1.19
0.12
8.7
7.4
24.1
24.8
mmol/l
—
10
79
35
329
1.08
0.11
3.3
3.1
20.3
241.8
mg/l
0.60
26
211
117
1151
1.07
0.09
17.1
14.2
39.8
40.2
%
0.17
90
857
6
58
1.04
0.08
6.0
3.3
4839.3
2507.7
u/ml
—
6
48
21
195
1.09
0.08
1.7
1.6
—
—
—
0
0
8
75
1.07
0.07
2.3
2.2
—
—
—
0
0
22
206
1.08
0.07
1.3
1.3
1.7
6.2
u/ml
—
7
79
10
91
1.11
0.04
4.8
3.8
—
—
—
0
0
35
361
0.96
0.04
3.4
2.9
7.1
7.6
mmol/l
0.39
29
302
15
156
0.96
0.00
1.3
1.5
—
—
—
0
0
14
141
0.99
0.00
2.8
1.5
—
—
—
0
0
23
232
0.99
0.00
1.7
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
11.5
—
0
8
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
5.2
—
0.7
—
0
6
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
15.0
—
1162.6
—
0
5
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
2.9
—
0
6
6
64
0.94
0.00
1.2
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
22.2
—
2542.6
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
7.1
—
0
5
0
5
0.00
0.00
0.0
40.0
—
97.6
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
129.4
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_CONNSOFT_THX and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_CONNSOFT_THX 0.906 [0.64, 1.28] 0.579
Birth year 1.0 [0.99, 1.01] 0.96

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 492 females with CD2_BENIGN_CONNSOFT_THX died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_CONNSOFT_THX 0.943 [0.68, 1.3] 0.719
Birth year 0.984 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 322 males with CD2_BENIGN_CONNSOFT_THX died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CONNSOFT_THX.

N-year risk Females Males
1 0.103% 0.156%
5 0.562% 0.944%
10 1.566% 2.524%
15 2.838% 4.836%
20 5.077% 7.941%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_CONNSOFT_THX – Benign neoplasm: Connective and other soft tissue of thorax

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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