Other sideroblastic anaemias

D3_SIDEROANAMIEAOTHER

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D64.3 Hospital discharge: ICD-9 — 2850X Hospital discharge: ICD-8 — 28500 Cause of death: ICD-10 — D64.3 Cause of death: ICD-9 — 2850X Cause of death: ICD-8 — 28500 2 out of 7 registries used, show all original rules.	137
4. Check minimum number of events None	137
5. Include endpoints None	137
6. Filter based on genotype QC (FinnGen only)	137

Control definitions (FinnGen only)

Control exclude: D3_APLASTICANDOTHANAEMIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D64
Name in latin: Aliae anaemia sideroblasticae

NAME	D3_SIDEROANAMIEAOTHER
CONTROL_EXCLUDE	D3_APLASTICANDOTHANAEMIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D643
HD_ICD_9	2850X
HD_ICD_8	28500
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D643
COD_ICD_9	2850X
COD_ICD_8	28500
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other sideroblastic anaemias based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1579	915	635
Only index persons	1006	616	390
Unadjusted period prevalence (%)
Whole population	0.02	0.03	0.02
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	71.02	71.37	70.40
Only index persons	65.44	64.99	66.15

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	137	67	70
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	66.35	63.51	69.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
126: Matched controls
1258

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D64.3

ICD-10 Finland

Other sideroblastic anaemias

+∞

147.5

111

D64.9

ICD-10 Finland

Anaemia, unspecified

70.1

55.4

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

13.0

19.2

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

5.0

15.7

239

B82

ICPC

Anaemia other/unspecified

27.6

15.7

28500

ICD-8 Finland

Other and unspecified anaemias, Hypochromic anaemia with iron loading

+∞

11.6

D50.0

ICD-10 Finland

Iron deficiency anaemia secondary to blood loss (chronic)

19.4

11.6

ZX120

NOMESCO Finland

Intravenous

7.0

11.1

UJF92

NOMESCO Finland

Capsular endoscopy

26.0

10.5

WW500

NOMESCO Finland

Blood transfusion

11.0

10.2

XW000

NOMESCO Finland

Bone marrow biopsy

14.0

9.1

D50.8

ICD-10 Finland

Other iron deficiency anaemias

53.8

8.8

UJF32

NOMESCO Finland

Coloscopy

3.3

8.1

202

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

6.6

7.9

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

17.9

6.9

A02BC02

ATC

pantoprazole; systemic

2.8

6.7

613

D64.0

ICD-10 Finland

Hereditary sideroblastic anaemia

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

240

4.64

17.78

4.3

1.8

4.0

3.0

mg/l

2.07

201

(3001122) Ferritin [Mass/volume] in Serum or Plasma

390

3.32

10.89

8.0

2.4

201.8

121.3

ug/l

1.35

347

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

7.31

9.08

1.3

2.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.88

6.59

1.5

1.2

—

(3012544) pH of Venous blood

3.33

6.11

5.8

3.3

—

(3002032) Base excess in Venous blood by calculation

3.29

5.81

6.0

3.2

0.5

1.5

mmol/l

0.31

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

3.89

5.22

4.6

3.7

49.9

44.7

0.27

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

349

2.21

4.80

6.9

3.0

2103.2

1443.8

ng/l

0.64

287

(40758558) Short blood count panel - Blood

248

2.29

4.66

14.0

6.6

—

(3000991) Gas panel - Venous blood

3.13

4.43

13.2

7.5

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

164

2.43

4.41

3.0

4.2

3.2

e6/l

0.26

(42870588) Differential panel, method unspecified - Blood

315

2.11

4.15

10.2

4.6

—

(3003396) Base excess in Arterial blood by calculation

120

2.56

4.14

8.4

5.4

2.3

1.3

mmol/l

0.32

(40768797) Stomach Pathology biopsy report

127

2.40

3.66

1.4

1.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.56

3.57

2.0

2.6

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

510

1.92

3.48

11.4

5.6

1.2

mmol/l

0.52

426

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

117

2.39

3.42

2.4

1.7

—

(3001604) Monocytes [#/volume] in Blood

475

1.91

3.42

10.1

5.2

0.6

e9/l

0.02

407

(3013115) Eosinophils [#/volume] in Blood

495

1.90

3.37

11.3

5.3

0.2

e9/l

0.43

436

(3006315) Basophils [#/volume] in Blood

477

1.90

3.36

10.1

5.3

0.0

e9/l

0.11

411

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

119

2.35

3.30

2.4

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

170

2.15

3.26

2.6

1.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

439

1.86

3.14

2.4

1.9

92.4

100.4

pmol/l

0.72

209

(3004588) Protein electrophoresis panel - Serum or Plasma

2.67

3.10

1.2

2.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

174

2.09

3.06

2.7

2.8

0.7

1.3

e6/l

0.96

105

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

10.31

3.00

4.8

1.8

—

(3018010) Neutrophils/100 leukocytes in Blood

456

1.81

2.91

11.5

5.3

60.9

58.4

0.74

417

(3007853) Bacteria identified in Skin by Aerobe culture

114

2.22

2.76

1.7

1.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.44

2.75

1.5

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

3.94

2.72

6.3

1.8

3.2

3.7

g/l

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.78

2.62

1.3

1.5

—

(3045788) Cell count panel - Pleural fluid

5.65

2.57

1.5

1.2

—

(3021589) Normoblasts [#/volume] in Blood

432

1.74

2.56

15.8

9.7

0.0

e9/l

0.21

349

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.62

2.54

2.3

1.6

—

(3026008) Bacteria identified in Urine by Culture

344

1.77

2.53

3.5

3.3

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

4.55

2.51

2.4

2.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

382

1.73

2.45

4.1

3.1

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

470

1.68

2.29

11.8

4.9

1.2

mmol/l

0.36

418

(3042111) Morphology [Interpretation] in Bone marrow Narrative

4.04

2.28

1.7

1.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.55

2.27

2.5

2.4

—

(3045414) Leukocytes [Presence] in Urine

2.92

2.25

3.7

2.1

—

(3023368) Bacteria identified in Blood by Culture

293

1.74

2.25

7.2

4.0

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

5.72

2.23

3.6

2.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

418

1.67

2.21

5.9

4.0

33.1

57.5

ng/l

1.03

295

(40760888) Immunoglobulin light chains.free panel - Serum

3.82

2.18

2.1

4.2

—

(3042936) Bacteria identified in Isolate by Culture

148

1.93

2.18

2.7

1.9

—

(3034770) Mitochondria Ab [Titer] in Serum

4.43

2.17

1.2

1.1

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

402

1.66

2.16

2.7

2.1

76.6

78.3

nmol/l

0.22

340

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.69

2.15

1.1

1.5

—

(3018418) pH of Serum or Plasma

314

1.70

2.14

8.3

3.8

7.4

—

(3014051) Protein [Presence] in Urine by Test strip

3.33

2.13

4.4

2.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.94

2.04

1.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

559

1.61

1.99

20.2

9.1

3.9

4.1

e9/l

0.46

486

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

4.67

1.96

1.2

1.9

—

(3012441) Differential panel - Pleural fluid

4.67

1.96

1.2

1.9

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

4.67

1.96

1.4

1.3

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.87

1.95

2.0

2.1

—

(3002582) Erythrocytes [#/volume] in Urine

330

1.65

1.94

4.1

3.1

26.9

75.4

e6/l

0.88

257

(21494755) Public health laboratory ask at order entry panel

0.00

1.93

0.0

1.3

—

(36304419) Bacteria [Presence] in Urine

288

1.66

1.90

3.8

2.9

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

4.28

1.84

2.4

1.7

33.8

31.5

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

4.28

1.84

1.0

1.8

—

(1761868) Lipid panel - Serum or Plasma

306

0.53

1.77

3.0

3.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

241

1.67

1.77

13.8

2.2

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

3.95

1.73

1.0

1.7

—

nmol/l

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

793

1.59

1.72

14.6

6.7

85.1

77.3

u/l

1.06

724

(3028026) IgM [Mass/volume] in Serum or Plasma

2.35

1.68

1.4

1.8

2.2

1.9

g/l

0.09

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

3.25

1.68

2.3

1.8

—

(3000330) Specific gravity of Urine by Test strip

2.17

1.66

5.5

4.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.66

1.63

2.2

2.1

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.21

1.60

4.5

2.9

122.3

126.1

g/l

0.24

(3007164) IgA [Mass/volume] in Serum or Plasma

164

1.72

1.58

1.3

3.3

2.4

g/l

0.41

(40768806) Pleura Pathology biopsy report

3.42

1.53

1.6

2.4

—

(3008037) Lactate [Moles/volume] in Venous blood

2.58

1.47

2.0

3.1

1.3

1.5

mmol/l

—

(3044640) Blood type and Crossmatch panel - Blood

332

1.53

1.46

10.2

2.2

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.40

1.46

1.1

1.5

15.4

10.1

g/l

—

(3013707) Erythrocyte sedimentation rate by Westergren method

727

1.49

1.43

5.5

4.1

20.8

13.3

mm/h

2.02

650

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

3.01

1.37

2.6

1.6

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.94

1.35

3.2

3.5

59.0

61.2

ml/min/173m2

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.03

1.32

4.1

1.9

16.1

9.7

g/l

1.01

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

2.43

1.31

1.1

1.5

34.5

35.9

g/l

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.17

1.31

5.3

3.1

23.9

24.6

mmol/l

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

606

1.44

1.28

8.5

4.1

7.3

6.7

mmol/l

1.29

564

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.99

1.27

2.3

3.1

2.9

2.3

mmol/l

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.92

1.24

2.8

2.9

5.4

5.1

kpa

0.36

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.37

1.20

8.8

1.5

86.0

90.2

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.37

1.20

2.3

1.7

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.55

1.16

1.2

1.3

0.2

g/l

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

2.32

1.12

2.1

3.1

115.2

265.7

mg/l

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

2.32

1.12

2.1

3.1

89.9

30.7

mg/l

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.43

1.10

1.2

1.3

0.9

1.1

g/l

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.02

1.06

5.6

2.3

0.8

0.7

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.32

1.04

1.8

1.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.94

1.03

5.6

2.3

1.6

1.3

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.28

0.94

2.3

1.7

—

(3038515) Glucose [Moles/volume] in Venous blood

2.19

0.92

2.0

3.1

7.2

7.6

mmol/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

188

1.47

0.92

1.1

1.2

0.8

u/ml

—

(40760892) CBC W Ordered Manual Differential panel - Blood

197

1.46

0.91

9.0

5.7

—

(3028626) Oxygen [Partial pressure] in Capillary blood

2.12

0.90

2.2

2.4

8.3

7.9

kpa

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

136

0.56

0.89

1.6

1.4

—

(3022313) Gas panel - Capillary blood

1.87

0.87

2.1

3.1

—

(3033658) Prothrombin time (PT) actual/Normal

253

1.40

0.86

8.7

3.4

73.3

86.7

2.32

247

(4034850)

1.98

0.85

24.7

16.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

122

1.55

0.85

19.7

9.2

—

(3032080) INR in Blood by Coagulation assay

431

1.33

0.84

15.1

9.0

1.2

1.3

inr

0.23

115

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

246

1.39

0.82

1.7

1.8

546.2

452.6

pmol/l

0.63

202

(3037467) Urinalysis macro (dipstick) panel - Urine

697

1.32

0.81

5.2

4.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.65

0.81

1.7

1.4

—

(3019150) Specific gravity of Urine by Refractometry

220

1.40

0.80

4.7

4.9

1.0

kg/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.71

0.80

14.3

6.1

—

(3031040) Bacteria [#/volume] in Urine by Automated count

678

1.31

0.80

6.1

4.7

—

4312.6

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

230

1.39

0.78

9.6

1.6

1.3

1.5

mg/l

0.26

176

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.63

0.78

1.8

3.7

1.2

mmol/l

0.38

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

101

1.54

0.74

1.7

1.5

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.04

0.73

1.0

1.1

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

206

1.39

0.73

6.7

3.3

631.3

125.9

ng/l

0.84

160

(3015377) Calcium [Moles/volume] in Serum or Plasma

354

1.31

0.72

4.3

3.0

2.4

2.3

mmol/l

0.05

300

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

106

983

1.35

0.71

33.8

14.6

26.5

25.1

mg/l

0.18

791

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

480

1.28

0.69

14.9

4.0

—

(3022621) pH of Urine by Test strip

1.59

0.68

3.7

3.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.66

0.67

1.5

1.7

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.60

0.0

2.0

—

(40768804) Tissue Pathology biopsy report

401

1.26

0.59

2.2

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.59

0.0

1.4

—

39.5

—

(4094501)

0.00

0.59

0.0

1.2

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.56

0.53

1.7

3.2

1.6

—

(3000492) Spirometry study

1.47

0.51

1.5

1.4

—

(3013512) EKG study

324

1.24

0.47

4.9

4.2

—

(40761535) Cells panel - Urine sediment

1.43

0.46

5.7

3.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.43

0.43

1.4

1.3

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.41

0.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.41

0.0

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

125

1.32

0.39

1.6

1.7

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

369

0.83

0.37

4.4

5.2

2.8

3.0

ug/l

0.06

320

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

294

0.82

0.35

3.6

4.5

14.8

21.1

—

149

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.41

0.35

2.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.36

0.32

1.1

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

106

0.74

0.30

4.4

3.7

—

(3019225) pH of Specimen

103

1.29

0.29

4.8

3.1

—

(4010399)

0.67

0.27

1.2

1.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

949

0.88

0.26

4.4

4.6

4.0

4.5

mmol/l

4.49

862

(3009508) Creatinine [Moles/volume] in Urine

305

1.15

0.25

3.5

3.0

7.4

7.1

mmol/l

0.16

244

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.69

0.24

1.8

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.33

0.23

1.2

1.1

—

(3020891) Body temperature

1.33

0.23

11.4

4.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

966

0.88

0.23

4.7

5.2

2.3

2.6

mmol/l

3.95

874

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

513

1.12

0.22

2.6

2.9

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

2.3

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.21

0.0

1.6

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

1.6

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.21

0.0

3.5

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

4.8

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.21

0.0

1.2

—

(3044889) 12 lead EKG panel

704

1.11

0.21

4.6

4.1

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

943

0.90

0.20

4.4

4.6

1.4

1.5

mmol/l

0.96

854

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.16

0.19

4.2

3.6

3.4

4.4

pmol/l

—

(3029937) Albumin [Presence] in Urine by Test strip

272

1.13

0.19

4.0

4.5

0.0

estimate

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.20

0.18

1.4

1.7

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

909

1.11

0.18

7.0

6.2

41.4

40.4

mmol/mol

0.35

833

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.73

0.17

6.4

5.6

24.9

24.4

mmol/l

—

(40761511) CBC panel - Blood by Automated count

104

1013

1.11

0.16

33.9

13.7

—

(3025941) Bacteria identified in Stool by Culture

1.12

0.16

1.4

1.3

—

(3000494) Fungus identified in Specimen by Culture

121

1.17

0.15

1.2

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

484

1.09

0.14

6.7

5.7

0.0

estimate

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

954

0.92

0.13

5.5

4.9

6.3

6.0

mmol/l

1.08

861

(3002256) Pathology report gross observation

123

1.15

0.13

1.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

908

1.08

0.11

28.5

14.3

73.4

75.9

ml/min/173m2

0.41

732

(3020682) Albumin/Creatinine [Ratio] in Urine

320

1.08

0.11

3.7

3.9

8.6

12.6

mg/mmol

0.30

192

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

911

0.93

0.10

4.0

4.1

1.2

1.3

mmol/l

0.55

818

(3009542) Hematocrit [Volume Fraction] of Blood

839

1.07

0.10

43.4

15.7

34.9

38.8

2.40

565

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.05

0.08

2.0

1.8

—

(3035350) Ketones [Presence] in Urine by Test strip

483

1.06

0.07

5.1

4.3

0.0

estimate

—

(40761536) Microorganisms panel - Urine sediment

0.85

0.07

4.1

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

213

0.93

0.06

3.2

3.0

0.6

0.8

ug/l

0.89

150

(4035726)

1.12

0.05

1.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

272

0.95

0.05

5.5

3.8

—

(3009261) Glucose [Presence] in Urine by Test strip

488

1.04

0.04

5.3

4.3

0.0

estimate

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

721

1.03

0.02

3.8

14.6

15.0

pmol/l

0.51

644

(3003694) ABO and Rh group [Type] in Blood

268

0.96

0.02

1.6

1.3

—

(3024731) MCV [Entitic volume]

108

1072

1.04

0.02

54.2

21.6

90.3

91.4

0.88

108

1048

(3035941) MCH [Entitic mass]

108

1073

1.03

0.01

54.1

21.5

29.4

30.4

3.27

108

1049

(3000963) Hemoglobin [Mass/volume] in Blood

108

1073

1.03

0.01

54.7

21.8

119.0

134.1

g/l

13.84

108

1047

(3012516) Albumin [Mass/volume] in Urine

296

0.97

0.00

3.3

3.1

54.7

527.4

mg/l

0.87

183

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

113

0.97

0.00

1.1

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

887

1.01

0.00

4.4

4.7

1.9

2.0

mu/l

0.42

789

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

385

1.02

0.00

5.2

4.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

228

1.01

0.00

4.8

4.4

—

(3022145) Colonoscopy Study observation

105

1.05

0.00

1.4

1.3

—

(36660697) Celiac disease serology panel - Serum

0.93

0.00

1.0

1.2

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.0

—

11.0

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.3

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.0

—

2.9

—

(3026285) Alpha 1 antitrypsin [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

1.4

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.3

—

(3006245) CD3-CD19+ cells/100 cells in Blood

0.00

0.0

3.0

—

3.0

—

(3007449) CD3+CD8+ (T8 suppressor) cells/100 cells in Blood

0.00

0.0

2.8

—

28.4

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3019060) Gas panel - Arterial blood

0.94

0.00

2.7

3.2

—

(44806420)

0.00

0.0

2.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.6

—

18.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.6

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

11.8

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

3.6

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3027831) CD3-CD16+CD56+ (Natural killer) cells/100 cells in Blood

0.00

0.0

2.6

—

10.6

—

(3022756) Ceruloplasmin [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

278.5

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.3

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

1.7

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.8

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.1

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

5.3

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

85.7

—

(3004451) EKG impression Narrative

0.00

0.0

1.4

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.2

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

63.8

—

(42869593) Oxyhemoglobin/Hemoglobin.total [Pure mass fraction] in Capillary blood

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_SIDEROANAMIEAOTHER and mortality.

Females

Parameter	HR [95% CI]	p-value
D3_SIDEROANAMIEAOTHER	2.545 [1.95, 3.32]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 302 out of 565 females with D3_SIDEROANAMIEAOTHER died.

Males

Parameter	HR [95% CI]	p-value
D3_SIDEROANAMIEAOTHER	2.558 [1.77, 3.69]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.096

During the follow-up period (1.1.1998 — 31.12.2019), 213 out of 380 males with D3_SIDEROANAMIEAOTHER died.

Mortality risk

Mortality risk for people of age

years, who have D3_SIDEROANAMIEAOTHER.

N-year risk	Females	Males
1	0.199%	0.607%
5	1.237%	3.073%
10	2.959%	8.425%
15	5.515%	15.674%
20	9.1%	26.053%

Relationships between endpoints

↥

Index endpoint: D3_SIDEROANAMIEAOTHER – Other sideroblastic anaemias

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other sideroblastic anaemias

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints