No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
233 |
4. Check minimum number of eventsNone |
233 |
5. Include endpointsNone |
233 |
6. Filter based on genotype QC (FinnGen only) |
226 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced tremor
based on the number of shared cases.
Similar with more cases:
- Other extrapyramidal and movement disorders in other diseases
- Extrapyramidal and movement disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1381 | 777 | 594 |
| Only index persons | 1216 | 696 | 520 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 65.08 | 66.43 | 63.19 |
| Only index persons | 63.63 | 65.18 | 61.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 226 | 121 | 105 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | 60.69 | 59.86 | 61.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 233
- Matched controls
- 2330
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G25.1
ICD-10 Finland
Drug-induced tremor
+∞
307.7
233
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
26.9
129.9
106
70
N05AH03
ATC
olanzapine; systemic
20.0
98.0
89
70
R25.1
ICD-10 Finland
Tremor, unspecified
33.2
97.6
67
28
N04AA02
ATC
biperiden; systemic
46.6
88.7
54
15
N05AX12
ATC
aripiprazole; systemic
24.7
84.3
65
36
N03AG01
ATC
valproic acid; systemic, rectal
18.1
83.9
78
63
N05AN01
ATC
lithium; oral
36.0
77.9
51
18
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
30.7
65.6
45
18
N05AH04
ATC
quetiapine; oral
9.2
64.6
119
238
N05AX08
ATC
risperidone; systemic
11.6
62.5
78
97
N05AA02
ATC
levomepromazine; systemic
14.5
50.7
50
43
C07AA05
ATC
propranolol; systemic
7.0
49.0
116
289
F29
ICD-10 Finland
Unspecified nonorganic psychosis
16.9
46.2
41
29
G25.0
ICD-10 Finland
Essential tremor
14.8
43.9
42
34
N05AB03
ATC
perphenazine; systemic, rectal
14.0
40.5
40
34
N03AX09
ATC
lamotrigine; oral
11.1
38.7
45
49
P99
ICPC
Psychological disorders other
15.0
38.3
36
28
N03AE01
ATC
clonazepam; systemic
8.8
34.0
48
67
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
39.6
29.8
37
11
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
6.9
27.8
49
87
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
7.5
27.6
44
70
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
50.8
26.3
31
7
N05BA06
ATC
lorazepam; systemic, sublingual
6.7
23.8
42
74
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
35.1
22.1
28
9
N06AB04
ATC
citalopram; systemic
3.9
21.1
88
315
N05AH02
ATC
clozapine; systemic
20.8
21.1
31
17
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.8
20.2
53
134
T36
ICD-10 Finland
Poisoning by systemic antibiotics
8.2
20.0
28
38
N05BA04
ATC
oxazepam; oral
3.6
19.7
101
411
N05BA01
ATC
diazepam; systemic, rectal
4.2
19.4
65
198
F20.9
ICD-10 Finland
Schizophrenia, unspecified
21.0
19.2
28
15
N05CD07
ATC
temazepam; oral
4.4
18.8
57
161
AA1AD
NOMESCO Finland
CT of head and brain
3.4
18.3
98
407
P72
ICPC
Schizophrenia
15.6
17.8
29
21
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
20.7
17.8
26
14
P29
ICPC
Psychological sympt/compl other
5.6
17.8
37
76
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
194.1
17.8
18
*
N05AF03
ATC
chlorprothixene; systemic
14.2
17.7
30
24
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
28.1
17.3
23
9
F31
ICD-10 Finland
Bipolar affective disorder
30.2
16.8
22
8
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
25.3
16.8
23
10
F31.8
ICD-10 Finland
Other bipolar affective disorders
20.4
16.4
24
13
N05AD01
ATC
haloperidol; systemic
13.7
16.3
28
23
F31.1
ICD-10 Finland
Bipolar affective disorder, current episode manic without psychotic symptoms
26.8
16.3
22
9
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
51.5
16.3
19
*
ZY010
NOMESCO Finland
Hospital outpatient
6.2
16.0
29
52
N06AB03
ATC
fluoxetine; oral
4.0
15.6
51
151
N06AX12
ATC
bupropion; oral
5.3
15.2
33
70
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
19.1
14.1
21
12
N05BE01
ATC
buspirone; oral
7.0
13.9
22
34
N05AC02
ATC
thioridazine; oral
14.0
13.7
23
18
N06AX16
ATC
venlafaxine; oral
3.5
13.2
54
185
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.2
12.4
36
97
N05AF05
ATC
zuclopenthixol; systemic
28.5
12.2
16
6
N06AX11
ATC
mirtazapine; oral
2.7
12.1
105
545
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
10.5
12.1
23
24
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
5.6
12.0
24
47
F31.3
ICD-10 Finland
Bipolar affective disorder, current episode mild or moderate depression
31.9
11.8
15
5
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
6.1
11.7
21
37
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
5.2
11.5
25
53
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
5.7
11.3
22
42
A06AD11
ATC
lactulose; oral
3.2
11.3
51
185
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
14.9
11.2
18
13
N07BB01
ATC
disulfiram; oral
5.8
11.1
21
39
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.6
10.9
40
127
F25.00
ICD-10 Finland
Schizoaffective syndrome, manic type with only simultaneous bipolar and schizophrenic symptoms
29.6
10.9
14
5
SPAT1240
SPAT
Therapeutic discussion
3.7
10.8
37
112
N05CF01
ATC
zopiclone; oral
2.5
10.7
100
531
F99
ICD-10 Finland
Mental disorder, not otherwise specified
12.9
10.5
18
15
G21.1
ICD-10 Finland
Other drug-induced secondary parkinsonism
+∞
10.5
10
*
F31.5
ICD-10 Finland
Bipolar affective disorder, current episode severe depression with psychotic symptoms
+∞
10.5
10
*
P27
ICPC
Fear of mental disorder
34.2
10.4
13
*
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
19.9
10.4
15
8
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
5.7
10.3
20
38
SPAT1307
SPAT
Psychosocial counselling and guidance
5.4
10.3
21
42
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.5
10.1
39
128
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.0
10.0
51
198
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
9.7
79
390
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
4.3
9.6
26
66
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.9
9.6
30
85
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
9.6
60
260
N06AX03
ATC
mianserin; oral
4.7
9.6
23
53
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
4.7
9.6
23
53
N05AA01
ATC
chlorpromazine; systemic, rectal
13.1
9.5
16
13
F61.0
ICD-10 Finland
Mixed personality disorders
11.4
9.5
17
16
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.6
9.2
33
103
P98
ICPC
Psychosis NOS/other
38.3
9.1
11
*
IGY02, ,
SPAT
25.2
9.0
12
5
F60.9
ICD-10 Finland
Personality disorder, unspecified
13.3
9.0
15
12
R42
ICD-10 Finland
Dizziness and giddiness
2.5
8.8
70
340
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.9
8.7
46
181
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.9
8.6
26
72
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.1
8.5
24
63
N06AB06
ATC
sertraline; oral
3.1
8.5
40
148
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
7.6
8.4
19
27
F31.21
ICD-10 Finland
Bipolar disorder, manic episode with mood incongruent psychotic symptoms
+∞
8.4
8
*
F25.10
ICD-10 Finland
Schizoaffective syndrome, depressive type with only concomitant bipolar and schizophrenic symptoms
+∞
8.4
8
*
N06AB10
ATC
escitalopram; oral
2.6
8.4
59
270
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
15.2
8.3
13
9
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
10.6
8.2
15
15
Z2446
NOMESCO Finland
Social worker
3.8
8.1
26
75
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
8.1
40
152
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
6.5
8.0
20
33
SPAT1243
SPAT
Psychiatric/psychological examination
9.0
8.0
16
19
Z2445
NOMESCO Finland
Psychologist
4.5
7.9
20
48
F31.2
ICD-10 Finland
Bipolar affective disorder, current episode manic with psychotic symptoms
46.6
7.8
9
*
29580
ICD-8 Finland
Schizophrenia, Other
46.6
7.8
9
*
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
7.1
7.8
18
27
R53
ICD-10 Finland
Malaise and fatigue
2.3
7.7
77
411
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
19.1
7.7
11
6
P73
ICPC
Affective psychosis
26.0
7.6
10
*
N06AA12
ATC
doxepin; systemic
3.6
7.3
25
75
F20.09
ICD-10 Finland
Paranoid schizophrenia UNS
16.4
7.3
11
7
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
7.3
55
259
N06AA06
ATC
trimipramine; systemic
7.0
7.3
17
26
ZYC01
NOMESCO Finland
Remote contact by phone
3.7
7.2
24
71
F22.0
ICD-10 Finland
Delusional disorder
12.6
7.2
12
10
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
7.4
7.1
16
23
188
Kela drug reimbursment
Psychosis requiring demanding treatment
17.3
6.8
10
6
F31.31
ICD-10 Finland
Bipolar disorder depressive episode with somatic syndrome
41.3
6.8
8
*
C03CA01
ATC
furosemide; systemic
2.1
6.8
86
502
G20
ICD-10 Finland
Parkinson disease
5.8
6.8
18
33
IGY02
NOMESCO Finland
Psychiatric monitoring contact
6.2
6.8
17
29
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.0
6.7
32
119
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
6.6
51
242
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
6.5
79
452
N05BA12
ATC
alprazolam; oral
2.8
6.5
35
139
F20.0
ICD-10 Finland
Paranoid schizophrenia
71.7
6.5
7
*
F25.21
ICD-10 Finland
Schizoaffective syndrome, mixed type with prolonged schizophrenic than bipolar symptoms
71.7
6.5
7
*
N06AB05
ATC
paroxetine; oral
3.7
6.5
21
61
ZY000
NOMESCO Finland
Hospital inpatient
14.8
6.5
10
7
SPF00
NOMESCO Finland
Reparation of dental prosthesis without impressions
6.3
6.4
16
27
L28
ICPC
Limited function/disability (L)
2.4
6.3
51
246
AA400
NOMESCO Finland
Electroconvulsive therapy
18.6
6.3
9
5
F25.01
ICD-10 Finland
Schizoaffective syndrome, manic type with prolonged schizophrenic than bipolar symptoms
+∞
6.3
6
*
Z72.8
ICD-10 Finland
Other problems related to lifestyle
27.5
6.3
8
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.0
6.3
28
100
R55
ICD-10 Finland
Syncope and collapse
2.7
6.2
36
148
P74
ICPC
Anxiety disorder/anxiety state
4.0
6.2
18
48
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
6.2
33
130
N06AX26
ATC
vortioxetine; oral
3.5
6.2
22
68
IGY99
NOMESCO Finland
Other psychiatric treatment contact
9.0
6.1
12
14
F39
ICD-10 Finland
Unspecified mood [affective] disorder
9.0
6.1
12
14
N06AA09
ATC
amitriptyline; systemic
2.8
6.1
33
131
XA800
NOMESCO Finland
Neuropsychological investigation
4.1
6.1
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
161
943
3.29
16.15
8.3
7.0
1.22
1.21
mmol/l
0.33
140
794
22
11
21.93
15.42
21.3
21.1
1039.36
1627.09
nmol/l
1.45
22
11
84
362
3.06
14.16
1.8
1.6
1119.48
1171.51
nmol/l
0.19
64
270
59
208
3.46
13.86
2.1
1.6
1.62
1.53
%
0.34
52
183
119
645
2.73
12.76
4.2
3.0
29.35
31.66
u/l
0.35
110
613
19
11
18.66
12.75
16.2
11.7
662.05
920.27
nmol/l
1.13
19
11
143
881
2.61
11.38
7.1
5.9
1.22
1.21
mmol/l
0.29
131
806
168
1132
2.74
10.91
6.2
4.7
6.86
6.68
mmol/l
0.34
159
1046
121
714
2.45
10.20
3.7
3.2
—
—
—
0
0
82
405
2.58
10.15
1.7
1.7
90411442.64
453.60
pmol/l
0.49
73
327
127
769
2.43
10.07
2.4
1.9
88.15
94.95
pmol/l
0.79
68
391
178
1264
2.73
9.89
7.1
4.4
5508.60
704.71
e6/l
—
5
17
133
830
2.40
9.75
4.8
4.6
34.99
35.53
g/l
0.48
127
781
37
120
3.48
9.72
2.4
1.5
—
—
—
0
0
102
569
2.41
9.61
3.3
2.0
430.63
192.40
u/l
1.24
93
532
160
1117
2.38
8.61
18.0
9.3
4.10
4.19
e9/l
0.16
143
979
56
247
2.67
8.57
6.1
5.9
1.10
1.05
mmol/l
0.66
49
228
195
1496
2.86
8.47
8.3
7.4
76.28
78.83
u/l
0.39
189
1391
35
120
3.26
8.39
2.5
1.3
—
—
—
0
0
102
601
2.24
8.15
3.3
2.4
57.73
64.34
u/l
0.38
97
555
65
317
2.46
8.03
2.9
3.5
0.81
0.82
mmol/l
0.35
59
299
136
904
2.21
8.00
21.8
12.4
1.29
1.26
inr
0.13
31
277
85
468
2.29
7.97
2.2
2.0
3.06
3.18
mg/l
0.17
70
403
45
188
2.73
7.60
5.3
4.4
1.43
1.96
mmol/l
0.50
39
150
67
340
2.36
7.53
2.9
2.9
1.99
0.91
e6/l
1.29
44
196
76
411
2.26
7.34
7.1
4.2
1.02
1.02
kg/l
0.15
12
58
103
640
2.09
6.92
2.6
3.2
2.35
2.35
mmol/l
0.29
90
562
63
323
2.30
6.85
2.8
1.9
—
—
—
0
0
49
226
2.48
6.74
2.4
1.9
—
—
—
0
0
49
230
2.43
6.48
2.5
1.9
—
—
—
0
0
94
577
2.05
6.42
3.1
3.1
0.32
0.39
e6/l
0.24
80
437
17
43
4.19
6.29
2.6
3.6
34.29
37.11
umol/l
0.19
17
38
48
228
2.39
6.17
5.1
6.9
1.51
1.24
mmol/l
0.20
36
191
18
50
3.82
5.88
1.3
1.2
—
—
—
0
0
114
776
1.92
5.59
2.6
2.3
72.17
75.59
nmol/l
0.67
97
681
78
469
2.00
5.49
1.6
1.6
21.40
21.31
nmol/l
0.02
67
398
131
947
1.88
5.22
6.2
3.9
0.00
0.00
estimate
0.50
20
205
176
1405
2.03
5.15
6.3
3.8
14.34
14.84
pmol/l
2.19
166
1248
163
1269
1.95
5.11
5.3
3.1
50.90
49.09
u/l
0.11
153
1181
57
314
2.08
5.06
3.2
3.2
3.37
2.12
e6/l
0.45
35
173
131
961
1.83
4.84
6.2
3.9
0.00
0.02
estimate
0.50
17
184
205
1749
2.43
4.84
7.4
4.5
1.97
1.92
mu/l
0.25
186
1580
129
949
1.81
4.66
8.6
5.2
0.00
0.00
estimate
-0.00
16
191
109
764
1.80
4.62
5.9
3.9
36.90
36.17
ng/l
0.03
86
547
29
126
2.49
4.48
6.2
4.1
0.91
2.04
mmol/l
0.97
24
94
27
115
2.52
4.35
2.5
1.8
—
—
—
0
0
6
5
12.26
3.78
2.8
2.6
36783.33
31961.00
ug/l
—
6
5
12
30
4.16
3.65
1.8
1.3
—
—
—
0
0
12
30
4.16
3.65
1.8
1.3
—
—
—
0
0
172
1429
1.78
3.64
4.6
4.1
13.07
12.03
mm/h
0.39
162
1303
7
9
7.97
3.58
2.9
1.1
—
—
—
0
0
62
393
1.79
3.53
4.0
3.7
259.67
392.26
ng/l
0.23
46
308
6
6
10.22
3.51
1.0
1.2
—
—
—
0
0
6
6
10.22
3.51
1.0
1.2
—
—
—
0
0
24
108
2.36
3.46
1.7
3.0
4.23
4.39
pmol/l
0.32
17
94
42
240
1.91
3.31
6.3
7.0
104.12
103.92
mmol/l
0.09
42
240
85
598
1.66
3.30
3.8
3.8
11.47
9.44
mg/mmol
0.18
54
377
6
7
8.76
3.28
1.0
1.4
—
—
—
0
0
76
523
1.67
3.20
6.1
4.1
0.00
0.00
estimate
-0.00
16
188
100
746
1.60
3.02
7.0
4.0
—
—
—
0
0
34
188
1.95
2.94
2.5
2.4
45.45
35.60
u/l
0.22
29
156
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
15
58
2.70
2.93
2.3
2.6
0.24
0.39
u/ml
—
8
29
210
1898
2.08
2.88
25.0
14.4
21.17
22.76
mg/l
0.35
181
1502
82
590
1.60
2.84
3.1
3.3
2718.35
1223.85
ng/l
0.70
74
496
5
7
7.27
2.56
1.0
1.3
—
—
—
0
0
5
7
7.27
2.56
1.0
1.3
—
—
—
0
0
6
11
5.57
2.56
2.0
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
11
5.57
2.56
1.2
1.2
—
—
—
0
0
61
418
1.62
2.55
1.9
1.9
0.99
1.30
mg/l
0.74
48
338
54
359
1.66
2.54
2.1
2.7
2.44
2.44
mmol/l
0.15
42
306
15
63
2.48
2.52
3.1
3.0
—
—
—
0
0
105
820
1.51
2.46
3.1
2.7
131.67
117.16
ug/l
0.32
95
747
37
224
1.77
2.43
12.5
7.5
—
—
—
0
0
6
12
5.10
2.41
2.0
1.3
—
—
—
0
0
61
424
1.59
2.40
1.4
1.2
3.20
1.38
u/ml
—
8
103
6
13
4.71
2.28
1.0
1.2
2.17
1.75
mmol/l
—
6
13
13
54
2.49
2.24
1.5
1.7
—
—
—
0
0
202
1837
1.75
2.22
6.5
4.6
6.20
5.98
mmol/l
1.39
183
1673
5
9
5.65
2.22
3.0
1.8
62.40
51.33
umol/l
—
5
9
8
24
3.41
2.20
1.0
1.2
—
—
—
0
0
9
30
3.08
2.17
1.4
1.5
—
—
—
0
0
13
55
2.44
2.16
1.5
1.7
—
—
—
0
0
8
25
3.28
2.11
1.0
1.2
—
—
—
0
0
28
163
1.82
2.10
2.3
2.3
5.96
8.35
ug/l
0.36
20
149
5
10
5.08
2.08
1.0
2.4
536.20
842.00
u/ml
—
5
10
10
39
2.63
1.96
1.6
1.7
—
—
—
0
0
30
183
1.73
1.93
5.7
6.6
1.15
1.21
mmol/l
0.17
30
178
7
22
3.25
1.89
2.3
2.2
—
—
—
0
0
216
2023
1.93
1.87
28.7
16.8
84.72
77.81
umol/l
1.71
216
2023
19
101
1.96
1.87
6.1
3.1
0.75
0.66
%
0.66
19
101
9
36
2.56
1.76
1.6
1.9
—
—
—
0
0
9
36
2.56
1.76
1.6
1.9
—
—
—
0
0
11
48
2.36
1.73
2.5
1.6
—
—
—
0
0
19
105
1.88
1.69
6.1
3.1
1.14
1.37
%
0.60
19
105
7
25
2.85
1.66
1.4
1.7
—
—
—
0
0
7
25
2.85
1.66
1.4
1.7
—
—
—
0
0
5
14
3.62
1.62
2.0
2.1
—
—
—
0
0
7
26
2.74
1.59
2.3
2.0
—
—
—
0
0
6
20
3.05
1.59
1.8
2.1
—
—
—
0
0
6
20
3.05
1.59
1.8
2.1
—
—
—
0
0
6
20
3.05
1.59
1.8
2.1
—
—
—
0
0
12
58
2.13
1.52
3.6
3.3
8.77
8.22
kpa
0.61
12
58
193
1787
1.47
1.39
20.0
13.4
75.42
80.63
ml/min/173m2
1.96
163
1460
6
23
2.65
1.37
1.3
1.8
—
—
—
0
0
5
17
2.98
1.36
1.4
1.1
372.40
257.82
pmol/l
—
5
17
130
1138
1.32
1.30
3.1
3.1
—
—
—
0
0
5
18
2.82
1.29
1.0
1.1
—
—
—
0
0
189
1752
1.42
1.27
8.0
5.8
41.00
39.96
mmol/mol
0.74
176
1631
8
38
2.14
1.19
1.6
1.6
—
—
—
0
0
5
20
2.53
1.15
1.0
1.2
—
—
—
0
0
11
58
1.94
1.14
1.6
1.4
—
—
—
0
0
7
31
2.30
1.11
1.0
1.3
—
—
—
0
0
25
170
1.53
1.10
1.6
2.1
—
—
—
0
0
5
21
2.41
1.09
2.0
1.7
—
—
—
0
0
23
155
1.54
1.06
2.5
2.7
58.20
62.94
ml/min/173m2
—
7
68
5
22
2.30
1.04
2.0
1.7
—
—
—
0
0
5
22
2.30
1.04
2.0
1.7
—
—
—
0
0
5
22
2.30
1.04
2.0
1.7
—
—
—
0
0
5
23
2.20
0.98
2.0
1.7
—
—
—
0
0
5
23
2.20
0.98
1.2
2.1
15.71
16.01
ug/l
—
5
23
5
23
2.20
0.98
2.0
1.7
—
—
—
0
0
12
69
1.78
0.98
3.6
1.8
—
—
—
0
0
8
144
0.54
0.97
1.5
1.7
—
—
—
0
0
56
452
1.31
0.97
3.4
2.3
—
—
—
0
0
9
51
1.79
0.95
1.0
1.1
—
4.10
—
0
6
196
1853
1.36
0.95
5.2
4.5
1.32
1.47
mmol/l
5.38
178
1699
30
222
1.40
0.89
2.1
3.1
5.85
9.24
umol/l
0.80
25
197
196
1862
1.33
0.83
5.1
4.5
4.37
4.62
mmol/l
2.47
181
1720
12
73
1.68
0.83
3.8
2.1
—
—
—
0
0
219
2119
1.56
0.83
42.5
21.0
38.11
40.08
%
3.07
200
1984
200
1909
1.34
0.79
5.7
5.1
2.52
2.72
mmol/l
2.14
182
1751
25
184
1.40
0.78
1.9
2.3
—
—
—
0
0
6
34
1.78
0.77
1.0
1.4
—
—
—
0
0
6
34
1.78
0.77
1.5
1.5
—
—
—
0
0
5
24
2.11
0.75
1.2
1.4
—
—
—
0
0
29
221
1.36
0.74
5.1
4.6
31.53
32.50
%
0.16
17
145
7
39
1.82
0.73
1.4
1.6
—
—
—
0
0
5
25
2.02
0.73
1.0
1.4
—
—
—
0
0
7
40
1.77
0.72
1.1
1.4
—
—
—
0
0
100
897
1.20
0.67
3.5
2.5
—
—
—
0
0
7
43
1.65
0.67
1.4
1.6
—
—
—
0
0
7
43
1.65
0.67
3.0
4.8
32.33
24.30
mg/l
—
7
28
15
209
0.70
0.63
5.3
3.4
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
6
37
1.64
0.56
2.3
3.3
46.50
59.05
%
—
6
37
34
279
1.26
0.54
3.3
2.4
22.86
23.25
%
0.05
27
240
33
271
1.25
0.52
1.9
1.4
—
—
—
0
0
59
516
1.19
0.52
2.5
2.8
7698.57
6869.15
umol/l
0.04
53
443
9
65
1.40
0.51
1.2
2.9
99.44
90.48
%
—
9
65
187
1797
1.21
0.50
4.8
4.0
1.58
1.28
mmol/l
3.67
172
1641
13
93
1.42
0.49
1.0
1.0
—
—
—
0
0
7
49
1.44
0.46
1.1
1.2
—
—
—
0
0
13
95
1.39
0.44
1.8
1.9
—
—
—
0
0
33
388
0.83
0.42
2.3
3.0
0.76
0.75
ug/l
0.04
20
266
8
59
1.37
0.41
1.4
1.2
—
—
—
0
0
5
34
1.48
0.40
1.6
1.6
—
—
—
0
0
6
41
1.48
0.36
1.8
2.1
120.33
131.07
g/l
—
6
30
25
209
1.22
0.36
1.5
4.1
3.26
26.78
ug/l
0.58
18
166
28
328
0.83
0.35
1.3
1.3
8.89
28.30
iu/ml
—
7
104
6
44
1.37
0.34
1.3
1.4
—
—
—
0
0
7
53
1.33
0.31
1.1
1.8
—
—
—
0
0
7
55
1.28
0.30
1.3
2.1
—
—
—
0
0
56
511
1.13
0.29
1.5
1.7
1.39
1.34
mmol/l
0.18
48
424
8
67
1.20
0.26
1.4
2.6
0.34
0.61
g/l
—
8
61
10
78
1.29
0.24
1.4
2.3
3.78
3.52
g/l
—
10
73
10
78
1.29
0.24
1.4
2.3
7.47
7.38
g/l
—
10
73
10
78
1.29
0.24
1.4
2.3
—
—
—
0
0
5
38
1.32
0.23
1.0
1.3
—
—
—
0
0
29
324
0.88
0.22
2.3
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
226.31
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
5
43
1.17
0.21
1.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
6
48
1.26
0.20
1.5
1.4
—
—
—
0
0
6
49
1.23
0.20
1.2
1.4
—
—
—
0
0
7
59
1.19
0.18
1.4
1.2
—
—
—
0
0
8
72
1.11
0.16
1.4
2.3
11.74
10.29
g/l
—
8
66
8
72
1.11
0.16
1.4
2.3
3.26
3.00
g/l
—
8
67
57
538
1.08
0.16
4.3
4.4
27.24
21.13
%
1.29
25
260
71
676
1.07
0.16
4.1
4.9
1.96
2.46
ug/l
0.41
62
604
9
78
1.16
0.15
1.2
1.6
—
180.00
—
0
5
11
96
1.15
0.10
1.5
1.3
—
—
—
0
0
5
63
0.79
0.08
1.2
1.8
—
—
—
0
0
32
309
1.04
0.04
1.3
1.3
1.20
7.62
u/ml
2.54
11
129
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
10.23
—
0
6
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
59
1.02
-0.00
1.7
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
16.51
—
0
8
7
75
0.93
-0.00
1.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
64
0.94
-0.00
1.3
2.4
35.77
38.11
g/l
—
6
59
0
8
0.00
-0.00
0.0
8.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_TREMOR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_TREMOR | 1.727 [1.43, 2.08] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.175 |
During the follow-up period (1.1.1998 — 31.12.2019), 219 out of 683 females with DRUGADVERS_TREMOR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_TREMOR | 2.187 [1.73, 2.77] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 212 out of 529 males with DRUGADVERS_TREMOR died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_TREMOR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.176% | 0.271% |
| 5 | 1.097% | 2.284% |
| 10 | 2.546% | 5.616% |
| 15 | 4.83% | 10.66% |
| 20 | 8.486% | 17.829% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_TREMOR – Drug-induced tremor
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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