Drug-induced tremor

DRUGADVERS_TREMOR

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G25.1# 1 out of 7 registries used, show all original rules.	210
4. Check minimum number of events None	210
5. Include endpoints None	210
6. Filter based on genotype QC (FinnGen only)	210

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	DRUGADVERS_TREMOR
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G251
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Drug-induced tremor based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1381	777	594
Only index persons	1216	696	520
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.03	0.02
Median age at first event (years)
Whole population	65.08	66.43	63.19
Only index persons	63.63	65.18	61.55

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	210	116	94
Unadjusted period prevalence (%)	0.04	0.04	0.04
Median age at first event (years)	59.75	58.41	61.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
191: Matched controls
1908

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G25.1

ICD-10 Finland

Drug-induced tremor

+∞

276.4

191

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

21.0

52.2

N05AH03

ATC

olanzapine; systemic

26.5

47.3

N03AG01

ATC

valproic acid; systemic, rectal

15.1

36.0

N04AA02

ATC

biperiden; systemic

38.7

35.9

R25.1

ICD-10 Finland

Tremor, unspecified

27.0

35.4

N05AH04

ATC

quetiapine; oral

8.8

35.3

176

C07AA05

ATC

propranolol; systemic

7.4

31.5

208

N05AX12

ATC

aripiprazole; systemic

19.7

26.9

G25.0

ICD-10 Finland

Essential tremor

26.6

26.9

N05AN01

ATC

lithium; oral

29.2

25.4

F31.7

ICD-10 Finland

Bipolar affective disorder, currently in remission

36.6

24.6

N05AX08

ATC

risperidone; systemic

9.2

23.9

N05AA02

ATC

levomepromazine; systemic

13.3

21.9

F31.9

ICD-10 Finland

Bipolar affective disorder, unspecified

13.1

18.6

N03AX09

ATC

lamotrigine; oral

10.6

18.2

F31.30

ICD-10 Finland

Bipolar disorder Depressive episode without somatic syndrome

24.7

17.4

N05AB03

ATC

perphenazine; systemic, rectal

12.1

17.0

N05AH02

ATC

clozapine; systemic

27.4

16.4

P99

ICPC

Psychological disorders other

19.4

16.1

G25.9

ICD-10 Finland

Extrapyramidal and movement disorder, unspecified

37.0

16.1

F20.9

ICD-10 Finland

Schizophrenia, unspecified

24.7

16.0

N05AF03

ATC

chlorprothixene; systemic

18.1

15.7

F29

ICD-10 Finland

Unspecified nonorganic psychosis

13.5

15.6

N05BA04

ATC

oxazepam; oral

3.9

15.0

283

F20.00

ICD-10 Finland

Paranoid schizophrenia continuous

27.7

15.0

N05BA01

ATC

diazepam; systemic, rectal

4.7

14.6

151

F31

ICD-10 Finland

Bipolar affective disorder

24.6

14.6

F31.8

ICD-10 Finland

Other bipolar affective disorders

19.5

14.2

P72

ICPC

Schizophrenia

19.5

14.2

F31.1

ICD-10 Finland

Bipolar affective disorder, current episode manic without psychotic symptoms

32.9

14.2

N06AB04

ATC

citalopram; systemic

3.9

14.1

235

N03AE01

ATC

clonazepam; systemic

6.8

13.9

F31.20

ICD-10 Finland

Bipolar disorder, manic episode with mood-congruent psychotic symptoms

37.1

13.8

F31.6

ICD-10 Finland

Bipolar affective disorder, current episode mixed

30.9

13.2

N05BA06

ATC

lorazepam; systemic, sublingual

7.5

13.0

F31.0

ICD-10 Finland

Bipolar affective disorder, current episode hypomanic

19.0

12.8

N05AD01

ATC

haloperidol; systemic

8.8

11.8

N05CD07

ATC

temazepam; oral

4.1

11.3

145

N05AF05

ATC

zuclopenthixol; systemic

46.2

11.1

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

5.4

10.8

P29

ICPC

Psychological sympt/compl other

7.2

10.4

T36

ICD-10 Finland

Poisoning by systemic antibiotics

7.6

9.6

AA1AD

NOMESCO Finland

CT of head and brain

3.0

9.4

289

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

4.6

8.9

F32.3

ICD-10 Finland

Severe depressive episode with psychotic symptoms

12.4

8.7

R4160

NOMESCO Finland

Other therapy enhancing rehabilitation

13.6

8.5

F31.4

ICD-10 Finland

Bipolar affective disorder, current episode severe depression without psychotic symptoms

13.6

8.5

N06AX11

ATC

mirtazapine; oral

2.6

8.5

397

N06AA06

ATC

trimipramine; systemic

11.5

8.5

G21.1

ICD-10 Finland

Other drug-induced secondary parkinsonism

+∞

8.4

F31.21

ICD-10 Finland

Bipolar disorder, manic episode with mood incongruent psychotic symptoms

+∞

8.4

N05AC02

ATC

thioridazine; oral

9.6

8.2

F99

ICD-10 Finland

Mental disorder, not otherwise specified

12.5

8.2

F31.3

ICD-10 Finland

Bipolar affective disorder, current episode mild or moderate depression

23.2

8.1

X69

ICD-10 Finland

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

8.4

8.1

N05CF01

ATC

zopiclone; oral

2.5

7.9

419

N05AA01

ATC

chlorpromazine; systemic, rectal

12.6

7.7

F61.0

ICD-10 Finland

Mixed personality disorders

12.6

7.7

ZY010

NOMESCO Finland

Hospital outpatient

6.1

7.6

P73

ICPC

Affective psychosis

83.2

7.5

N06AX12

ATC

bupropion; oral

5.0

7.4

F31.2

ICD-10 Finland

Bipolar affective disorder, current episode manic with psychotic symptoms

+∞

7.3

R42

ICD-10 Finland

Dizziness and giddiness

2.8

7.3

244

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.6

7.3

284

F32.9

ICD-10 Finland

Depressive episode, unspecified

3.4

7.2

123

C03CA01

ATC

furosemide; systemic

2.4

7.2

387

N06AX16

ATC

venlafaxine; oral

3.2

7.1

142

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

4.1

7.0

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

4.1

7.0

SPAT1243

SPAT

Psychiatric/psychological examination

9.9

6.9

R53

ICD-10 Finland

Malaise and fatigue

2.6

6.8

255

P98

ICPC

Psychosis NOS/other

41.6

6.8

110

Kela drug reimbursment

Parkinson's disease and comparable movement disrorders

7.3

6.7

P74

ICPC

Anxiety disorder/anxiety state

7.9

6.5

N06AA12

ATC

doxepin; systemic

4.7

6.5

F22.0

ICD-10 Finland

Delusional disorder

11.6

6.4

F20.09

ICD-10 Finland

Paranoid schizophrenia UNS

27.7

6.3

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

2.9

6.2

167

G20

ICD-10 Finland

Parkinson disease

6.4

6.1

SPAT1240

SPAT

Therapeutic discussion

3.3

6.0

N06AB06

ATC

sertraline; oral

3.3

6.0

103

Mortality – FinRegistry

↥

Association

Association between endpoint DRUGADVERS_TREMOR and mortality.

Females

Parameter	HR [95% CI]	p-value
DRUGADVERS_TREMOR	1.727 [1.43, 2.08]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.175

During the follow-up period (1.1.1998 — 31.12.2019), 219 out of 683 females with DRUGADVERS_TREMOR died.

Males

Parameter	HR [95% CI]	p-value
DRUGADVERS_TREMOR	2.187 [1.73, 2.77]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 212 out of 529 males with DRUGADVERS_TREMOR died.

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_TREMOR.

N-year risk	Females	Males
1	0.176%	0.271%
5	1.097%	2.284%
10	2.546%	5.616%
15	4.83%	10.66%
20	8.486%	17.829%

Relationships between endpoints

↥

Index endpoint: DRUGADVERS_TREMOR – Drug-induced tremor

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced tremor

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints