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Pneumonia due to Haemophilus influenzae

DOID EFO Endpoint Browser PheWeb

J10_PNEUMOHAEM

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J14
  • Hospital discharge: ICD-9 — 4822
  • Hospital discharge: ICD-8 — 48210
  • Cause of death: ICD-10 — J14
  • Cause of death: ICD-9 — 4822
  • Cause of death: ICD-8 — 48210

2 out of 7 registries used, show all original rules.

136

4. Check minimum number of events

None

136

5. Include endpoints

None

136

6. Filter based on genotype QC (FinnGen only)

133

Control definitions (FinnGen only)

Control exclude
J10_INFLUPNEU

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J09-J18
Name in latin
Pneumonia ab Haemophilo influenzae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1201 473 712
Only index persons 836 381 455
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.02 0.01 0.02
Median age at first event (years)
Whole population 50.62 48.81 51.68
Only index persons 32.44 41.55 24.81

-FinnGen-

Key figures

All Female Male
Number of individuals 133 66 67
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 49.33 42.15 56.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
136
Matched controls
1360
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J18.9
ICD-10 Finland
Pneumonia, unspecified
63.3
126.0
80
30
J14
ICD-10 Finland
Pneumonia due to Haemophilus influenzae
+∞
105.3
87
*
48210
ICD-8 Finland
Other bacterial pneumonia, Haemophilus influenzae
+∞
38.4
35
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
65.0
19.6
22
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
8.4
16.7
24
34
4822A
ICD-9 Finland
Other bacterial pneumonia, Pneumonia due to Haemophilus influenzae [H. influenzae]
+∞
14.9
14
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.9
14.6
25
43
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
4.4
13.6
44
133
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.2
13.6
26
50
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
11.4
12.9
24
25
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.7
12.7
35
93
R03BB04
ATC
tiotropium bromide; inhalant
6.0
12.3
24
47
A41.3
ICD-10 Finland
Sepsis due to Haemophilus influenzae
+∞
11.6
11
*
H02AB06
ATC
prednisolone; systemic
3.3
10.8
81
416
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
+∞
10.5
10
*
R02
ICPC
Shortness of breath/dyspnoea
4.6
10.2
27
69
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.7
10.1
41
143
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
8.5
9.3
20
27
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
9.3
72
368
SPAT1262
SPAT
Handing over of treatment supplies
3.7
9.2
36
122
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
20.3
9.1
13
7
J01MA14
ATC
moxifloxacin; systemic
5.2
8.9
20
44
J45.9
ICD-10 Finland
Asthma, unspecified
3.5
8.5
36
128
GD1AD
NOMESCO Finland
Thorax CT examination
8.7
8.2
17
22
J01MA12
ATC
levofloxacin; systemic
3.4
8.1
35
126
WX723
NOMESCO Finland
CPAP therapy
9.4
8.1
16
19
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.2
7.9
23
63
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
12.9
7.8
13
11
R50.9
ICD-10 Finland
Fever, unspecified
3.5
7.5
29
97
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.6
7.4
28
92
D64.9
ICD-10 Finland
Anaemia, unspecified
4.0
7.4
23
66
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
+∞
7.4
7
*
48509
ICD-8 Finland
Bronchopneumonia, unspecified
+∞
7.4
7
*
J96.1
ICD-10 Finland
Chronic respiratory failure
31.9
7.2
9
*
TGC00
NOMESCO Finland
Bronchial lavation
13.0
7.2
12
10
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.7
7.2
83
501
C03CA01
ATC
furosemide; systemic
2.7
6.9
50
239
J45.1
ICD-10 Finland
Nonallergic asthma
4.4
6.7
18
46
R5140
NOMESCO Finland
Monitoring the use of the aid
3.6
6.7
24
76
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.3
6.6
28
99
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
10.0
6.4
12
13
48609
ICD-8 Finland
Pneumonia, unspecified
+∞
6.3
6
*
UDC00
NOMESCO Finland
Ear microscopy
3.9
6.3
20
58
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.1
6.2
18
49

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
44
58
10.74
33.57
6.2
3.5
0.52
0.37
%
0.33
21
16
44
62
10.01
31.77
6.3
3.4
0.10
0.13
%
0.07
20
16
44
64
9.68
30.92
6.5
3.4
0.15
0.29
%
0.41
20
17
45
69
9.25
30.24
6.5
3.2
0.64
0.87
%
0.25
21
23
34
12
37.16
26.98
3.9
1.8
15.44
17.52
%
—
19
5
44
83
7.36
24.20
6.0
3.7
—
—
—
0
0
63
200
5.01
19.11
8.1
3.2
—
—
—
0
0
31
52
7.43
18.72
16.7
5.2
25.36
24.59
mmol/l
0.41
31
52
28
21
16.46
17.43
5.4
2.3
—
—
—
0
0
28
22
15.69
17.11
7.1
2.4
2.73
2.68
mmol/l
0.02
20
13
28
22
15.69
17.11
7.3
2.4
8.38
9.14
kpa
0.69
28
22
28
22
15.69
17.11
7.3
2.4
5.25
5.09
kpa
0.30
28
22
21
9
27.24
15.66
2.7
1.2
87.10
91.42
%
—
21
9
24
16
17.92
15.58
5.9
3.4
62.79
58.12
%
0.53
24
16
22
13
19.90
14.89
6.1
3.2
—
—
—
0
0
20
9
25.73
14.71
7.3
2.1
—
—
—
0
0
23
16
17.02
14.69
4.9
3.2
5.66
4.04
e9/l
1.19
23
16
21
15
16.29
13.27
4.1
2.1
—
—
—
0
0
21
17
14.37
12.63
5.3
2.2
27.04
24.91
mmol/l
0.99
21
17
22
24
10.71
11.53
13.3
2.2
7.84
8.44
kpa
0.74
22
24
26
62
4.95
10.65
12.2
2.4
7.42
7.45
ph
—
15
5
60
274
3.13
9.51
5.4
3.7
0.00
0.00
estimate
-0.00
33
92
61
283
3.10
9.38
5.5
3.3
7.39
7.40
ph
0.05
38
51
57
259
3.07
9.03
5.0
2.9
—
—
—
0
0
22
57
4.41
8.07
11.5
2.9
77.88
74.19
e9/l
0.09
17
46
12
8
16.28
7.87
9.0
1.6
—
—
—
0
0
78
447
2.75
7.69
24.2
8.8
0.00
0.01
e9/l
0.17
71
372
76
435
2.69
7.44
11.3
4.7
1.20
1.22
mmol/l
1.75
69
397
59
298
2.73
7.41
5.4
3.0
—
—
—
0
0
20
55
4.09
6.76
6.1
3.8
—
—
—
0
0
78
474
2.51
6.45
17.5
5.4
—
—
—
0
0
80
494
2.50
6.36
5.1
3.4
0.00
0.01
estimate
0.50
41
101
80
495
2.50
6.32
6.0
4.6
0.00
0.00
estimate
-0.00
42
95
6
0
+∞
6.29
1.0
0.0
—
—
—
0
0
76
462
2.46
6.20
15.3
11.0
1.12
1.25
inr
1.23
50
134
80
500
2.46
6.11
5.0
3.5
0.00
0.00
estimate
-0.00
43
89
44
212
2.59
5.87
1.8
1.8
532.94
457.03
pmol/l
0.49
31
177
73
446
2.37
5.76
12.3
5.0
0.52
0.71
%
2.49
73
416
17
37
5.10
5.72
6.0
4.0
—
—
—
0
0
80
516
2.34
5.48
12.0
5.6
0.17
0.19
e9/l
0.80
74
461
78
498
2.33
5.47
10.5
5.3
0.62
0.56
e9/l
0.96
71
437
27
104
2.99
5.46
3.6
1.3
—
—
—
0
0
78
499
2.32
5.43
10.4
5.4
0.04
0.04
e9/l
0.90
71
441
73
462
2.25
5.12
12.6
5.4
8.40
8.54
%
0.15
73
435
73
462
2.25
5.12
12.4
5.1
2.11
2.90
%
3.74
73
434
64
385
2.25
5.07
5.6
3.0
27.84
50.89
ng/l
0.98
50
256
11
16
7.37
5.06
3.0
1.8
—
—
—
0
0
78
514
2.21
4.88
10.7
5.4
1.71
1.99
e9/l
1.24
71
466
8
8
10.53
4.58
5.0
1.6
30.88
33.50
pg
—
8
8
10
15
7.10
4.56
10.4
1.2
—
—
—
0
0
32
148
2.52
4.54
1.8
1.7
—
—
—
0
0
73
479
2.13
4.50
12.6
5.2
23.76
29.30
%
3.69
73
454
32
149
2.50
4.48
6.4
3.0
0.80
0.82
mmol/l
0.71
32
142
50
297
2.08
3.88
3.8
3.5
—
—
—
0
0
27
124
2.47
3.86
2.0
1.5
—
—
—
0
0
70
478
1.96
3.62
10.6
5.0
62.16
56.26
%
2.88
70
453
50
305
2.01
3.57
3.2
2.8
7.38
7.87
mmol/l
0.27
41
255
68
482
1.82
2.96
13.6
5.3
1.20
1.22
mmol/l
1.01
38
415
9
22
4.30
2.94
1.6
1.1
—
—
—
0
0
80
600
1.81
2.85
18.4
9.1
5.04
3.98
e9/l
1.96
75
530
5
6
8.59
2.77
1.0
1.2
—
—
—
0
0
39
236
1.91
2.76
1.8
1.8
3.72
2.86
mg/l
0.69
30
205
7
15
4.86
2.63
2.1
1.3
—
—
—
0
0
88
692
1.77
2.55
6.2
4.0
—
—
—
0
0
13
51
2.71
2.53
2.0
1.2
—
—
—
0
0
31
181
1.92
2.42
2.0
2.1
—
—
—
0
0
59
420
1.71
2.40
3.4
2.8
—
—
—
0
0
15
66
2.43
2.34
5.9
1.9
68.67
67.27
g/l
0.27
15
60
5
9
5.72
2.23
1.0
1.2
—
—
—
0
0
44
296
1.72
2.16
4.2
3.6
20.93
9.83
mg/mmol
0.44
24
185
42
280
1.72
2.13
3.2
3.0
75.92
65.96
mg/l
0.09
26
185
8
27
3.08
1.97
1.4
1.6
—
—
—
0
0
5
11
4.67
1.96
1.0
1.1
—
—
—
0
0
12
52
2.43
1.94
7.1
1.3
—
—
—
0
0
5
12
4.28
1.84
3.8
1.2
—
—
—
0
0
7
24
3.02
1.74
3.3
1.3
0.21
0.23
g/l
—
7
24
7
25
2.89
1.67
3.3
1.3
1.09
1.13
g/l
—
7
25
14
70
2.11
1.66
8.1
3.5
3.16
2.15
mmol/l
0.61
14
48
17
95
1.90
1.51
13.5
5.1
3.66
0.89
mmol/l
1.40
11
76
26
170
1.65
1.39
3.1
1.6
1594.13
1220.87
nmol/l
0.69
15
129
12
62
2.03
1.32
15.1
5.2
—
—
—
0
0
8
40
2.06
1.14
1.4
1.3
—
—
—
0
0
8
41
2.01
1.11
1.4
1.3
—
—
—
0
0
8
41
2.01
1.11
1.4
1.3
—
—
—
0
0
7
33
2.18
1.07
1.3
1.3
—
—
—
0
0
22
151
1.55
0.98
1.2
1.2
—
—
—
0
0
16
102
1.64
0.95
1.1
1.4
—
—
—
0
0
94
1027
0.73
0.91
4.0
3.9
1.51
1.33
mmol/l
0.73
76
934
36
280
1.39
0.87
4.5
3.0
—
—
—
0
0
5
23
2.22
0.77
1.6
1.2
—
—
—
0
0
23
169
1.43
0.76
1.3
1.3
2.84
5.44
u/ml
0.44
13
66
13
84
1.61
0.75
1.5
1.4
—
—
—
0
0
7
38
1.89
0.75
1.4
1.3
—
—
—
0
0
115
1079
1.43
0.74
30.6
10.8
33.51
20.55
mg/l
2.27
101
832
7
40
1.79
0.72
1.4
1.3
—
—
—
0
0
17
119
1.49
0.71
1.5
1.8
—
—
—
0
0
24
311
0.72
0.70
1.6
1.4
—
—
—
0
0
16
111
1.50
0.69
2.0
2.7
9.18
7.85
umol/l
0.10
11
98
26
199
1.38
0.69
5.0
1.3
3.63
2.52
g/l
0.57
20
120
15
211
0.68
0.69
3.4
3.0
0.90
0.83
ug/l
—
10
122
10
62
1.66
0.67
1.5
1.4
—
—
—
0
0
86
780
1.28
0.66
7.7
3.8
16.49
9.75
mm/h
2.67
79
715
34
274
1.32
0.66
1.6
1.7
1.41
1.36
mmol/l
0.12
23
226
5
30
1.69
0.62
1.0
1.1
—
—
—
0
0
99
1055
0.77
0.61
4.4
4.3
1.34
1.45
mmol/l
1.83
80
966
0
20
0.00
0.61
0.0
1.0
—
—
—
0
0
86
785
1.26
0.60
4.3
3.8
15.47
14.79
pmol/l
1.74
74
712
0
23
0.00
0.59
0.0
1.1
—
—
—
0
0
0
23
0.00
0.59
0.0
1.1
—
—
—
0
0
23
178
1.35
0.58
1.3
1.3
10.38
35.44
iu/ml
—
5
62
80
727
1.24
0.57
5.6
3.5
—
—
—
0
0
27
333
0.76
0.57
5.0
2.0
—
—
—
0
0
6
37
1.65
0.56
2.3
1.7
—
—
—
0
0
6
38
1.61
0.55
20.7
6.3
—
—
—
0
0
7
45
1.59
0.50
1.1
2.7
—
—
—
0
0
16
120
1.38
0.49
1.4
1.5
—
—
—
0
0
7
48
1.48
0.47
29.6
2.6
—
—
—
0
0
101
1060
0.82
0.42
4.5
4.3
4.48
4.69
mmol/l
1.16
83
980
0
15
0.00
0.41
0.0
1.5
—
4.72
—
0
9
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
13
99
1.35
0.37
1.8
1.8
—
—
—
0
0
10
134
0.73
0.37
1.5
1.2
—
—
—
0
0
6
43
1.41
0.35
2.2
2.4
—
—
—
0
0
6
86
0.68
0.34
1.2
1.2
—
—
—
0
0
7
55
1.29
0.30
20.3
6.2
0.57
0.76
%
—
7
55
7
56
1.26
0.30
20.3
6.2
1.31
1.63
%
—
7
56
9
119
0.74
0.28
1.1
1.4
—
—
—
0
0
104
1075
0.86
0.26
4.6
4.7
2.61
2.78
mmol/l
1.16
85
985
116
1129
1.19
0.24
27.7
10.8
—
—
—
0
0
5
38
1.33
0.23
1.2
1.2
—
—
—
0
0
39
425
0.88
0.22
1.8
2.0
—
—
—
0
0
5
42
1.20
0.21
22.6
6.3
25.60
24.39
mmol/l
—
5
42
0
11
0.00
0.21
0.0
3.3
—
—
—
0
0
0
11
0.00
0.21
0.0
9.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
293.60
—
0
5
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
211.30
—
0
13
6
50
1.21
0.20
3.2
3.0
—
—
—
0
0
18
157
1.17
0.18
1.3
1.6
—
—
—
0
0
32
349
0.89
0.18
6.2
4.8
3.17
3.00
ug/l
0.04
24
313
7
59
1.20
0.18
1.0
1.1
—
—
—
0
0
37
400
0.90
0.18
1.9
1.8
83.13
95.57
pmol/l
0.88
21
193
31
283
1.12
0.18
3.1
2.7
340.63
7731.52
umol/l
1.47
24
241
96
989
0.90
0.18
7.1
5.6
43.40
39.81
mmol/mol
2.35
88
928
28
254
1.13
0.18
7.5
7.4
—
—
—
0
0
6
75
0.79
0.16
1.3
1.3
—
—
—
0
0
23
211
1.11
0.12
3.5
3.5
—
—
—
0
0
25
232
1.10
0.10
1.2
1.3
0.65
0.68
u/ml
—
6
59
11
124
0.88
0.09
1.6
1.3
—
—
—
0
0
6
57
1.06
0.08
1.7
1.9
178.17
186.69
ng/l
—
6
45
7
64
1.10
0.08
3.0
3.2
4.23
4.52
pmol/l
—
7
55
104
1025
1.06
0.07
4.9
4.4
6.26
5.95
mmol/l
1.14
89
929
8
91
0.87
0.07
1.6
3.1
—
—
—
0
0
95
962
0.96
0.04
4.7
4.5
1.90
1.94
mu/l
0.08
82
864
114
1143
0.98
0.00
29.9
13.3
79.05
77.37
umol/l
0.29
114
1143
116
1158
1.01
0.00
15.9
9.2
48.83
26.04
u/l
0.56
111
1114
12
115
1.05
0.00
14.4
5.7
105.00
104.17
mmol/l
0.18
12
115
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
15.5
—
8.63
—
0
6
0
8
0.00
0.00
0.0
5.5
—
0.61
—
0
8
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
5.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
5.93
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
64.80
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
10.79
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint J10_PNEUMOHAEM and mortality.

Females

Parameter HR [95% CI] p-value
J10_PNEUMOHAEM 2.174 [1.13, 4.17] 0.019
Birth year 1.002 [0.99, 1.01] 0.643

During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 195 females with J10_PNEUMOHAEM died.

Males

Parameter HR [95% CI] p-value
J10_PNEUMOHAEM 3.488 [2.05, 5.92] < 0.001
Birth year 0.985 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 208 males with J10_PNEUMOHAEM died.

Mortality risk

Mortality risk for people of age

years, who have J10_PNEUMOHAEM.

N-year risk Females Males
1 0.25% 0.782%
5 1.35% 3.822%
10 3.604% 9.348%
15 7.552% 17.25%
20 13.386% 27.418%

Relationships between endpoints

↥

Index endpoint: J10_PNEUMOHAEM – Pneumonia due to Haemophilus influenzae

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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