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Pneumonia due to Haemophilus influenzae

DOID EFO Endpoint Browser PheWeb

J10_PNEUMOHAEM

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J14
  • Hospital discharge: ICD-9 — 4822
  • Hospital discharge: ICD-8 — 48210
  • Cause of death: ICD-10 — J14
  • Cause of death: ICD-9 — 4822
  • Cause of death: ICD-8 — 48210

2 out of 7 registries used, show all original rules.

119

4. Check minimum number of events

None

119

5. Include endpoints

None

119

6. Filter based on genotype QC (FinnGen only)

119

Control definitions (FinnGen only)

Control exclude
J10_INFLUPNEU

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J09-J18
Name in latin
Pneumonia ab Haemophilo influenzae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1201 473 712
Only index persons 836 381 455
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.02 0.01 0.02
Median age at first event (years)
Whole population 50.62 48.81 51.68
Only index persons 32.44 41.55 24.81

-FinnGen-

Key figures

All Female Male
Number of individuals 119 58 61
Unadjusted period prevalence (%) 0.02 0.02 0.03
Median age at first event (years) 48.71 40.63 56.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
101
Matched controls
1008
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J14
ICD-10 Finland
Pneumonia due to Haemophilus influenzae
+∞
66.1
56
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
59.3
46.5
54
19
48210
ICD-8 Finland
Other bacterial pneumonia, Haemophilus influenzae
+∞
35.5
32
*
4822A
ICD-9 Finland
Other bacterial pneumonia, Pneumonia due to Haemophilus influenzae [H. influenzae]
+∞
13.9
13
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
58.0
13.2
15
*
A41.3
ICD-10 Finland
Sepsis due to Haemophilus influenzae
+∞
10.6
10
*
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
+∞
9.5
9
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
9.5
9.4
19
24
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
12.3
8.1
14
13
TGC00
NOMESCO Finland
Bronchial lavation
48.9
7.8
9
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.9
7.0
31
103
A41.9
ICD-10 Finland
Sepsis, unspecified
24.4
6.8
9
*
H02AB06
ATC
prednisolone; systemic
3.1
6.8
55
283
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
5.3
6.6
20
45
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.9
6.5
60
335
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.5
6.5
23
62
D64.9
ICD-10 Finland
Anaemia, unspecified
5.7
6.4
18
37

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
27
13
26.57
36.63
4.3
1.8
15.0
17.8
%
—
13
6
24
17
17.43
27.00
8.1
2.4
8.4
9.3
kpa
0.69
24
17
24
17
17.43
27.00
8.0
2.4
2.9
2.6
mmol/l
—
16
10
24
17
17.43
27.00
8.1
2.4
5.3
5.0
kpa
0.46
24
17
23
16
17.58
26.08
5.9
2.4
—
—
—
0
0
19
12
18.65
22.45
6.1
3.1
61.7
62.1
%
0.03
19
12
18
11
19.10
21.56
5.6
3.5
—
—
—
0
0
18
12
17.50
20.64
4.8
3.0
5.6
4.5
e9/l
0.52
18
12
32
55
7.59
19.07
5.5
3.6
0.5
0.5
%
0.02
15
11
35
68
6.88
18.55
5.7
3.7
—
—
—
0
0
32
58
7.18
18.10
5.8
3.6
0.1
0.0
%
0.48
15
13
32
62
6.69
16.90
5.9
3.4
0.1
0.4
%
0.83
15
16
33
66
6.53
16.89
5.9
3.4
0.6
0.8
%
0.23
15
19
56
182
4.92
16.50
8.0
3.3
—
—
—
0
0
27
48
6.98
15.41
18.9
5.3
25.4
24.4
mmol/l
0.49
27
48
19
9
24.77
13.85
2.8
1.2
88.0
91.4
%
—
19
9
15
15
11.30
13.41
4.9
1.8
—
—
—
0
0
15
16
10.58
12.82
6.5
2.1
27.4
26.1
mmol/l
—
15
10
15
7
24.21
10.99
5.0
2.4
—
—
—
0
0
52
231
3.22
8.76
4.9
2.9
—
—
—
0
0
57
270
3.13
8.56
9.6
5.2
—
—
—
0
0
51
235
3.05
7.92
5.2
3.9
0.0
0.0
estimate
0.00
27
82
52
248
2.95
7.52
6.2
3.8
7.4
7.4
ph
0.09
32
47
19
50
4.33
6.84
6.4
3.6
—
—
—
0
0
16
37
4.84
6.72
6.4
4.6
—
—
—
0
0
46
219
2.79
6.52
10.9
4.6
—
—
—
0
0
6
0
+∞
6.30
1.0
0.0
—
—
—
0
0
66
383
2.62
6.24
12.3
5.2
1.2
1.2
mmol/l
1.53
60
350
10
16
6.73
6.06
3.2
1.8
—
—
—
0
0
19
59
3.64
5.44
15.8
2.4
7.4
7.4
ph
—
11
6
69
428
2.46
5.42
4.9
3.5
0.0
0.0
estimate
0.00
34
85
19
60
3.58
5.31
15.8
2.4
5.3
5.0
kpa
0.60
19
55
69
432
2.42
5.25
5.7
4.7
0.0
0.0
estimate
0.00
35
85
69
435
2.40
5.13
4.8
3.5
0.0
0.0
estimate
0.00
36
79
48
260
2.42
5.01
5.2
3.2
—
—
—
0
0
58
349
2.29
4.69
13.7
6.2
1.1
1.3
inr
1.69
40
98
7
6
12.28
4.33
2.1
4.0
84.4
72.3
%
—
7
6
62
393
2.21
4.32
23.4
9.2
0.0
0.0
e9/l
0.44
56
330
29
136
2.50
4.04
6.2
3.0
0.8
0.8
mmol/l
0.48
29
130
67
449
2.13
3.94
11.0
6.0
0.2
0.2
e9/l
0.28
61
400
65
433
2.10
3.85
9.2
5.7
0.6
0.6
e9/l
0.78
58
381
60
388
2.10
3.85
11.2
5.2
0.5
0.7
%
1.70
60
363
65
434
2.10
3.82
9.1
5.7
0.0
0.0
e9/l
0.28
58
386
28
133
2.45
3.78
2.0
1.7
—
—
—
0
0
54
341
2.07
3.64
5.9
3.3
30.3
51.8
ng/l
0.78
41
234
65
446
2.01
3.42
9.5
5.7
1.7
2.0
e9/l
0.89
58
401
8
14
6.04
3.40
12.5
4.4
—
—
—
0
0
60
402
1.99
3.37
11.3
5.2
2.2
2.8
%
2.37
60
378
60
402
1.99
3.37
11.4
5.5
8.3
8.5
%
0.26
60
381
35
193
2.15
3.32
1.7
1.8
535.0
451.9
pmol/l
0.43
25
159
60
417
1.89
2.90
11.4
5.4
24.0
29.0
%
2.35
60
394
21
104
2.24
2.55
2.1
1.6
—
—
—
0
0
41
262
1.86
2.50
3.8
3.6
—
—
—
0
0
5
8
6.46
2.39
1.0
1.3
—
—
—
0
0
5
8
6.46
2.39
1.4
1.8
—
—
—
0
0
5
8
6.46
2.39
1.4
1.8
—
—
—
0
0
5
8
6.46
2.39
1.4
1.8
—
—
—
0
0
5
8
6.46
2.39
1.4
1.8
—
—
—
0
0
5
8
6.46
2.39
7.0
1.6
33.2
33.4
pg
—
5
8
57
417
1.70
2.14
9.6
5.2
61.7
56.5
%
1.87
57
397
5
10
5.16
2.09
1.0
1.2
—
—
—
0
0
18
91
2.15
2.08
2.4
1.4
—
—
—
0
0
75
597
1.69
2.00
6.0
4.1
—
—
—
0
0
25
146
1.90
1.97
3.1
1.7
1639.6
1195.7
nmol/l
0.80
14
112
6
16
3.89
1.96
2.3
1.4
—
—
—
0
0
11
46
2.53
1.91
1.3
1.1
—
—
—
0
0
5
12
4.30
1.84
3.8
1.2
—
—
—
0
0
66
516
1.63
1.83
15.9
9.5
5.0
4.0
e9/l
1.56
61
456
17
89
2.06
1.81
13.5
4.9
3.7
0.7
mmol/l
1.51
11
69
13
62
2.23
1.73
6.5
2.9
68.5
67.6
g/l
0.14
13
56
32
211
1.71
1.70
1.7
1.9
3.8
2.9
mg/l
0.53
24
185
6
19
3.27
1.68
1.8
1.1
—
—
—
0
0
78
896
0.62
1.57
3.8
3.8
1.5
1.3
mmol/l
0.79
64
814
39
277
1.61
1.55
3.4
2.7
6.9
7.9
mmol/l
0.73
32
232
12
62
2.04
1.33
15.1
5.5
—
—
—
0
0
10
48
2.18
1.32
8.2
2.4
—
—
—
0
0
6
26
2.37
1.20
1.5
1.7
—
—
—
0
0
83
921
0.67
1.11
4.3
4.3
1.3
1.4
mmol/l
1.86
67
843
33
243
1.50
1.09
4.0
3.0
—
—
—
0
0
5
22
2.33
1.04
2.6
1.2
0.2
0.2
g/l
—
5
22
5
22
2.33
1.04
2.6
1.2
1.1
1.1
g/l
—
5
22
22
151
1.56
0.99
1.9
2.1
—
—
—
0
0
33
254
1.41
0.87
3.2
2.9
95.8
59.7
mg/l
0.31
20
165
15
97
1.63
0.86
2.1
2.8
9.7
8.4
umol/l
—
10
87
85
925
0.72
0.83
4.3
4.3
4.5
4.7
mmol/l
0.56
70
854
6
34
1.80
0.77
20.7
6.0
—
—
—
0
0
5
23
2.22
0.77
1.0
1.1
—
—
—
0
0
7
40
1.80
0.72
1.1
2.3
—
—
—
0
0
34
271
1.36
0.72
4.9
3.7
26.1
8.6
mg/mmol
0.61
19
168
13
85
1.59
0.72
1.2
1.5
—
—
—
0
0
79
856
0.77
0.62
6.7
5.7
43.4
40.1
mmol/mol
1.68
73
802
88
940
0.75
0.61
4.4
4.7
2.7
2.8
mmol/l
0.45
72
862
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
0
20
0.00
0.61
0.0
1.0
—
—
—
0
0
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
8
52
1.58
0.61
1.5
1.4
—
—
—
0
0
99
931
1.38
0.60
30.2
11.4
36.8
20.2
mg/l
2.81
88
723
20
257
0.73
0.57
1.5
1.4
—
—
—
0
0
14
191
0.70
0.56
3.4
3.0
1.0
0.8
ug/l
—
9
109
44
377
1.27
0.55
3.2
2.7
—
—
—
0
0
6
38
1.61
0.55
1.5
1.3
—
—
—
0
0
6
39
1.57
0.54
1.5
1.3
—
—
—
0
0
6
39
1.57
0.54
1.5
1.3
—
—
—
0
0
23
181
1.34
0.53
3.5
3.6
—
—
—
0
0
22
172
1.34
0.53
5.6
1.3
3.8
2.6
g/l
0.47
16
109
8
117
0.66
0.48
1.6
1.2
—
—
—
0
0
18
140
1.34
0.45
1.1
1.2
—
—
—
0
0
78
833
0.82
0.44
4.4
4.4
1.8
1.9
mu/l
0.26
67
747
5
32
1.59
0.43
2.6
1.8
—
—
—
0
0
5
32
1.59
0.43
1.4
1.3
—
—
—
0
0
7
103
0.66
0.41
1.1
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
10
73
1.40
0.36
1.6
1.4
—
—
—
0
0
18
146
1.27
0.35
1.2
1.3
2.9
6.3
u/ml
—
9
54
13
102
1.31
0.31
1.3
1.7
—
—
—
0
0
31
351
0.84
0.31
1.7
1.9
84.7
95.4
pmol/l
0.64
18
165
72
676
1.16
0.30
6.6
3.8
16.7
10.2
mm/h
2.00
65
624
28
243
1.20
0.30
1.7
1.7
1.4
1.4
mmol/l
0.12
18
201
7
55
1.29
0.30
20.3
6.1
0.6
0.8
%
—
7
55
8
108
0.72
0.30
1.8
1.3
—
—
—
0
0
7
56
1.27
0.30
20.3
6.0
1.3
1.6
%
—
7
56
5
72
0.68
0.27
1.2
1.2
—
—
—
0
0
9
75
1.22
0.25
1.3
1.8
—
—
—
0
0
5
37
1.37
0.24
1.6
1.3
—
—
—
0
0
5
37
1.37
0.24
2.4
2.4
—
—
—
0
0
5
38
1.33
0.23
1.6
1.3
—
—
—
0
0
67
635
1.13
0.22
5.9
3.5
—
—
—
0
0
0
11
0.00
0.21
0.0
3.3
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
106.5
—
0
11
0
11
0.00
0.21
0.0
2.5
—
3.9
—
0
11
0
10
0.00
0.21
0.0
9.9
—
—
—
0
0
0
10
0.00
0.21
0.0
2.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
6
50
1.21
0.20
1.7
1.9
178.2
186.2
ng/l
—
6
40
29
319
0.88
0.19
6.2
4.8
3.4
2.0
ug/l
0.50
22
286
27
244
1.14
0.18
3.1
2.9
352.0
8863.9
umol/l
1.47
19
209
11
130
0.83
0.17
1.5
1.7
—
—
—
0
0
34
366
0.90
0.16
1.9
2.0
—
—
—
0
0
97
991
0.89
0.14
30.1
13.9
78.9
78.5
umol/l
0.06
97
991
87
893
0.90
0.14
4.5
4.4
6.3
6.0
mmol/l
1.00
76
811
13
114
1.16
0.12
16.8
22.9
—
1.2
—
0
15
70
677
1.08
0.12
4.0
3.7
15.3
14.8
pmol/l
0.79
60
611
26
280
0.91
0.12
3.9
2.1
—
—
—
0
0
5
46
1.09
0.10
40.8
2.5
—
—
—
0
0
5
48
1.04
0.09
3.8
3.0
4.1
4.5
pmol/l
—
5
41
24
229
1.06
0.04
8.5
7.4
—
—
—
0
0
99
980
1.06
0.04
26.7
11.1
—
—
—
0
0
84
848
0.97
0.02
19.7
12.6
39.9
40.2
%
0.09
44
635
11
109
1.01
0.00
1.5
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
6.7
—
0.6
—
0
6
0
6
0.00
0.00
0.0
15.5
—
8.6
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
16.5
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
5
50
1.00
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
5.6
—
0
7
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
8
79
1.01
0.00
1.6
3.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint J10_PNEUMOHAEM and mortality.

Females

Parameter HR [95% CI] p-value
J10_PNEUMOHAEM 2.174 [1.13, 4.17] 0.019
Birth year 1.002 [0.99, 1.01] 0.643

During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 195 females with J10_PNEUMOHAEM died.

Males

Parameter HR [95% CI] p-value
J10_PNEUMOHAEM 3.488 [2.05, 5.92] < 0.001
Birth year 0.985 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 208 males with J10_PNEUMOHAEM died.

Mortality risk

Mortality risk for people of age

years, who have J10_PNEUMOHAEM.

N-year risk Females Males
1 0.25% 0.782%
5 1.35% 3.822%
10 3.604% 9.348%
15 7.552% 17.25%
20 13.386% 27.418%

Relationships between endpoints

↥

Index endpoint: J10_PNEUMOHAEM – Pneumonia due to Haemophilus influenzae

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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