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Ulcer of oesophagus, drug-induced

Endpoint Browser PheWeb

K11_OESULC_ADVERSE

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs — ANY
  • Hospital discharge: ICD-10 — K22.1#

1 out of 7 registries used, show all original rules.

173

4. Check minimum number of events

None

173

5. Include endpoints

None

173

6. Filter based on genotype QC (FinnGen only)

173

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
K22
Name in latin
Ulcus oesophagi

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 173 50 123
Unadjusted period prevalence (%) 0.04 0.02 0.05
Median age at first event (years) 57.64 55.56 58.48

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
163
Matched controls
1628
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K22.1
ICD-10 Finland
Ulcer of oesophagus
+∞
213.3
163
16
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
11.3
35.3
76
117
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
8.0
33.1
113
359
A02BC03
ATC
lansoprazole; oral
8.0
33.0
108
322
A02BC01
ATC
omeprazole; systemic
7.8
32.3
109
336
UJD02
NOMESCO Finland
Gastroscopy
16.8
27.5
45
36
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
29.2
18.9
25
10
K22.7
ICD-10 Finland
Barrett oesophagus
23.5
18.4
26
13
A02BA02
ATC
ranitidine; systemic
4.2
14.3
67
233
A02BA04
ATC
nizatidine; systemic
5.4
12.0
38
87
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
5.4
9.9
30
65
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
4.7
9.5
33
83
6241
FHL
Fund application (Nissen)
25.7
9.0
12
5
A02BC05
ATC
esomeprazole; systemic
2.8
8.9
80
417
5308A
ICD-9 Finland
Diseases of oesophagus, Other specified disorders of oesophagus[HERNIA HIATUS OESOPHAGI (""""SLIDING HERNIA"""")]
52.9
8.8
10
*
A02BA03
ATC
famotidine; systemic
6.2
8.7
23
42
A03FA02
ATC
cisapride; oral, rectal
4.5
8.5
30
77
5301B
ICD-9 Finland
Diseases of oesophagus, Oesophagitis[BARRETT'S OESOPHAGUS]
+∞
8.4
8
*
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
41.8
6.8
8
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
6.8
64
331
C15.5
ICD-10 Finland
Malignant neoplasm: Lower third of oesophagus
18.9
6.3
9
5
-
ICD-10 Finland
NA
7.2
6.2
14
21

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
49
223
2.67
7.22
2.7
2.5
20.1
22.8
%
0.65
37
195
40
169
2.78
6.77
1.9
1.3
—
—
—
0
0
49
231
2.56
6.67
2.8
2.5
2.4
2.2
g/l
0.68
49
211
74
428
2.27
6.34
5.6
4.2
7.4
7.4
ph
0.11
13
85
55
281
2.40
6.26
4.2
4.0
26.9
320.4
ng/l
1.98
47
245
22
72
3.36
5.73
6.1
7.3
—
—
—
0
0
52
274
2.28
5.43
6.3
4.7
1.0
1.0
kg/l
—
7
36
91
616
2.01
4.82
6.5
4.6
33.6
34.5
g/l
0.69
84
575
62
369
2.06
4.67
2.6
2.0
3.2
3.1
mg/l
0.05
54
317
37
185
2.27
4.30
6.7
5.6
2.9
0.8
mmol/l
3.15
30
149
118
904
1.96
4.08
6.0
4.6
—
—
—
0
0
60
369
1.96
4.04
1.8
1.7
16.4
21.1
nmol/l
1.84
53
304
48
273
2.05
4.02
5.0
4.1
—
—
—
0
0
67
439
1.86
3.67
5.5
5.1
—
—
—
0
0
8
13
6.39
3.54
1.3
1.5
—
—
—
0
0
73
497
1.81
3.50
3.6
2.6
140.8
170.6
ug/l
0.63
66
446
66
442
1.80
3.30
3.6
3.3
—
—
—
0
0
7
11
6.58
3.21
1.7
1.2
—
—
—
0
0
113
889
1.78
3.20
6.4
4.9
413.1
3246.2
e6/l
—
7
23
56
363
1.80
3.09
6.3
4.5
0.0
0.0
estimate
0.00
11
126
85
624
1.71
3.02
5.2
4.1
0.0
0.0
estimate
0.00
15
134
85
626
1.70
2.97
5.9
5.4
0.0
0.0
estimate
0.00
15
129
85
636
1.66
2.74
5.3
4.1
0.0
0.0
estimate
0.00
13
123
22
109
2.17
2.60
8.3
3.7
—
—
—
0
0
64
452
1.66
2.53
3.4
3.5
142.2
179.3
e6/l
0.09
53
356
64
452
1.66
2.53
3.9
3.3
2.3
2.3
mmol/l
0.55
58
393
43
272
1.77
2.53
1.6
1.7
2.0
1.5
mg/l
0.25
34
215
6
12
5.14
2.42
2.0
1.8
—
—
—
0
0
77
580
1.59
2.31
2.3
2.1
85.7
92.7
pmol/l
0.54
37
296
28
159
1.91
2.31
1.5
1.7
—
—
—
0
0
92
724
1.58
2.28
11.8
8.8
4.2
4.3
e9/l
0.24
81
624
7
18
4.01
2.27
1.4
3.9
—
—
—
0
0
29
456
0.56
2.12
3.2
4.5
—
—
—
0
0
84
661
1.53
2.00
9.0
5.5
1.2
1.2
mmol/l
0.07
79
579
7
21
3.43
1.98
2.0
1.9
—
—
—
0
0
0
51
0.00
1.92
0.0
4.6
—
—
—
0
0
7
22
3.27
1.90
1.0
1.5
—
—
—
0
0
107
893
1.52
1.89
5.4
4.6
—
—
—
0
0
6
18
3.41
1.76
2.3
1.5
—
—
—
0
0
6
18
3.41
1.76
2.3
1.5
—
—
—
0
0
6
18
3.41
1.76
2.3
1.5
—
—
—
0
0
6
18
3.41
1.76
2.3
1.5
—
—
—
0
0
30
190
1.70
1.75
1.8
2.6
1.9
1.8
%
0.19
25
168
52
379
1.53
1.72
2.9
3.2
—
—
—
0
0
80
638
1.47
1.72
15.8
10.1
1.3
1.3
inr
0.32
28
181
99
825
1.47
1.68
7.7
4.7
6.7
6.9
mmol/l
0.74
93
779
6
19
3.23
1.67
1.2
1.5
—
—
—
0
0
56
418
1.50
1.65
3.0
3.2
1190.9
65.8
mg/l
0.51
39
282
66
510
1.48
1.65
4.2
4.0
112.7
70.7
e6/l
0.36
52
376
79
636
1.45
1.58
5.8
5.6
1.6
1.8
e9/l
0.96
68
562
44
315
1.53
1.57
1.7
1.7
1158.1
1221.2
nmol/l
0.20
35
238
55
413
1.49
1.57
3.0
3.2
5.7
7.6
mmol/l
3.58
48
336
80
647
1.44
1.56
5.9
5.7
0.2
0.2
e9/l
1.50
70
561
59
451
1.47
1.54
6.7
4.4
—
—
—
0
0
5
15
3.40
1.53
1.0
3.3
—
—
—
0
0
117
1019
1.46
1.50
11.0
7.5
85.9
80.0
u/l
0.50
111
943
102
869
1.42
1.46
4.2
3.6
15.4
15.0
pmol/l
0.61
88
737
5
16
3.19
1.45
1.2
1.6
—
—
—
0
0
5
16
3.19
1.45
1.2
1.9
30.0
32.3
pg
—
5
16
77
626
1.41
1.43
5.9
5.5
0.6
0.6
e9/l
0.66
65
532
77
628
1.41
1.39
5.9
5.5
0.0
0.0
e9/l
0.05
64
537
42
311
1.46
1.27
8.1
6.9
—
—
—
0
0
22
141
1.64
1.24
3.5
3.6
—
—
—
0
0
22
141
1.64
1.24
1.9
2.6
72.7
68.2
e9/l
0.17
15
110
56
444
1.39
1.16
3.8
4.1
13.3
10.2
mg/mmol
0.23
38
292
8
40
2.05
1.13
1.1
1.2
—
—
—
0
0
122
1097
1.38
1.12
4.8
4.5
1.9
2.1
mu/l
1.02
107
950
5
21
2.42
1.10
1.0
1.1
—
—
—
0
0
21
138
1.59
1.09
3.5
3.6
1.0
1.6
mmol/l
0.21
16
105
21
139
1.58
1.06
1.7
1.3
—
—
—
0
0
5
22
2.31
1.04
3.4
2.3
4.3
4.9
e9/l
—
5
22
41
314
1.40
1.04
2.7
3.1
534.8
562.0
mosm/kgh2o
0.35
35
267
21
140
1.57
1.03
3.5
3.6
5.6
5.7
kpa
0.14
21
134
36
270
1.42
1.02
3.8
3.1
2.5
2.5
mmol/l
0.10
30
240
19
125
1.58
0.99
2.3
2.0
317.2
386.9
nmol/l
0.85
14
109
50
399
1.36
0.99
3.3
3.3
0.9
0.5
e6/l
0.32
39
304
5
23
2.21
0.98
3.4
2.4
61.2
57.9
%
—
5
23
8
144
0.53
0.98
3.3
3.5
—
—
—
0
0
0
32
0.00
0.96
0.0
1.4
—
—
—
0
0
22
152
1.51
0.94
1.9
1.4
—
—
—
0
0
7
128
0.53
0.92
1.6
1.5
—
—
—
0
0
12
72
1.72
0.87
1.9
3.4
—
—
—
0
0
31
398
0.73
0.82
3.0
3.1
0.7
0.8
ug/l
0.06
22
272
32
246
1.37
0.80
5.6
5.1
—
—
—
0
0
6
33
1.85
0.80
9.8
3.1
—
—
—
0
0
0
24
0.00
0.80
0.0
3.0
—
—
—
0
0
9
56
1.64
0.73
5.9
2.3
26.3
24.5
mmol/l
—
9
45
5
25
2.03
0.73
4.0
1.8
87.4
90.1
%
—
5
25
9
57
1.61
0.72
1.1
1.2
—
—
—
0
0
18
127
1.47
0.71
6.1
6.6
—
—
—
0
0
10
61
1.68
0.70
15.3
4.0
—
—
—
0
0
30
234
1.34
0.69
27.2
27.6
1.8
1.4
inr
—
5
26
5
28
1.81
0.66
1.0
2.6
—
—
—
0
0
111
1021
1.24
0.66
30.6
18.7
36.6
38.8
%
1.07
60
628
7
44
1.62
0.66
5.0
4.0
—
—
—
0
0
0
21
0.00
0.60
0.0
3.5
—
1.6
—
0
16
131
1235
1.25
0.58
30.0
17.4
26.5
26.2
mg/l
0.03
113
1027
51
438
1.23
0.57
3.3
2.3
—
—
—
0
0
8
55
1.48
0.57
12.6
3.5
4.2
4.0
mmol/l
—
8
50
16
116
1.42
0.57
4.8
4.4
—
—
—
0
0
15
203
0.71
0.55
1.3
1.5
2.4
3.1
g/l
—
9
123
6
96
0.61
0.54
8.2
2.4
—
—
—
0
0
43
365
1.24
0.53
4.3
3.8
—
—
—
0
0
70
626
1.20
0.52
5.9
4.4
60.8
53.6
ng/l
0.10
49
487
101
935
1.19
0.51
5.3
4.2
17.2
14.1
mm/h
1.10
96
850
133
1264
1.23
0.49
31.4
17.0
—
—
—
0
0
7
48
1.48
0.47
2.9
2.6
1.9
1.8
mg/l
—
7
42
7
49
1.45
0.46
6.3
2.3
7.1
8.1
kpa
—
7
43
24
293
0.79
0.45
1.4
1.3
—
—
—
0
0
20
158
1.30
0.44
1.3
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
16
124
1.32
0.40
2.9
2.3
—
—
—
0
0
8
61
1.33
0.40
1.3
1.2
—
—
—
0
0
30
352
0.82
0.40
3.8
3.5
—
—
—
0
0
14
109
1.31
0.34
1.2
1.4
—
—
—
0
0
14
109
1.31
0.34
5.5
4.0
—
—
—
0
0
6
87
0.68
0.34
9.0
2.6
19.3
10.4
g/l
—
6
76
6
47
1.29
0.32
2.2
1.9
—
—
—
0
0
7
52
1.36
0.31
1.0
1.3
—
—
—
0
0
62
572
1.13
0.29
16.1
10.9
0.0
0.0
e9/l
0.59
50
476
10
76
1.34
0.29
2.4
2.5
—
—
—
0
0
25
216
1.18
0.27
2.6
1.9
—
—
—
0
0
133
1288
1.14
0.27
15.1
11.1
24.9
24.3
u/l
0.16
125
1234
114
1182
0.90
0.24
5.0
4.9
4.2
4.3
mmol/l
0.46
105
1062
12
97
1.25
0.23
1.8
1.5
—
—
—
0
0
5
38
1.32
0.23
2.2
1.1
—
—
—
0
0
5
38
1.32
0.23
8.0
2.5
—
—
—
0
0
5
41
1.23
0.22
1.6
4.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.7
—
9.2
—
0
10
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
123
1193
1.11
0.21
5.7
5.2
6.1
6.2
mmol/l
0.66
111
1061
0
13
0.00
0.21
0.0
2.5
—
58.6
—
0
7
0
14
0.00
0.20
0.0
3.3
—
—
—
0
0
12
99
1.23
0.20
1.4
1.4
—
—
—
0
0
19
166
1.16
0.19
1.3
1.3
14.1
39.1
iu/ml
1.99
12
59
11
92
1.21
0.16
1.5
1.4
—
—
—
0
0
24
217
1.12
0.15
1.2
1.2
1.3
0.9
u/ml
—
6
62
9
106
0.84
0.13
1.8
1.5
—
—
—
0
0
17
152
1.13
0.12
1.2
1.3
1.2
26.4
u/ml
—
6
49
33
308
1.09
0.12
1.8
1.7
1.6
1.3
mmol/l
0.55
26
244
115
1175
0.94
0.12
4.7
4.9
1.4
1.4
mmol/l
0.12
106
1041
18
163
1.12
0.11
3.3
4.6
4.2
74.3
ug/l
0.85
18
139
112
1144
0.94
0.11
4.3
4.4
1.4
1.3
mmol/l
0.92
104
1009
6
57
1.05
0.08
1.3
1.4
—
—
—
0
0
69
710
0.95
0.08
6.6
5.4
5.3
2.7
ug/l
0.39
64
618
120
1218
0.95
0.07
5.5
5.5
2.3
2.5
mmol/l
2.03
107
1084
7
83
0.84
0.07
3.1
2.7
4.0
3.8
e9/l
—
7
58
9
83
1.09
0.07
1.3
1.6
—
—
—
0
0
48
495
0.96
0.06
2.1
2.3
—
—
—
0
0
115
1154
0.99
0.00
7.8
7.0
41.4
41.6
mmol/mol
0.09
107
1061
12
117
1.03
0.00
5.0
2.8
4.6
4.3
kpa
0.27
12
111
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
6.5
—
50.8
—
0
6
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
8
83
0.96
0.00
1.8
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
2.0
—
0
7
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
3.8
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: K11_OESULC_ADVERSE – Ulcer of oesophagus, drug-induced

GWS hits: 1

This endpoint is excluded (not available in FinRegistry).