No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
248 |
4. Check minimum number of eventsNone |
248 |
5. Include endpointsNone |
248 |
6. Filter based on genotype QC (FinnGen only) |
242 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Atlantoaxial subluxation
based on the number of shared cases.
Similar with more cases:
- Deforming dorsopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1586 | 993 | 576 |
| Only index persons | 1308 | 813 | 495 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 58.59 | 61.59 | 53.21 |
| Only index persons | 56.40 | 59.48 | 51.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 242 | 161 | 81 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | 53.70 | 52.60 | 55.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 248
- Matched controls
- 2480
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L01BA01
ATC
methotrexate; systemic
129.1
243.4
127
20
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
52.2
212.0
142
62
M43.4
ICD-10 Finland
Other recurrent atlantoaxial subluxation
+∞
201.6
165
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
29.0
168.4
156
137
L04AA13
ATC
[U] leflunomide
77.8
138.3
76
14
L88
ICPC
Rheumatoid/seropositive arthritis
42.1
135.8
88
32
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
24.9
130.6
110
77
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
77.7
124.2
68
12
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
47.2
123.3
76
23
M43.3
ICD-10 Finland
Recurrent atlantoaxial subluxation with myelopathy
+∞
121.0
106
*
A07EC01
ATC
sulfasalazine; oral, rectal
21.8
118.8
106
82
P01BA02
ATC
hydroxychloroquine; oral
19.1
114.7
113
104
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
62.6
114.0
65
14
L04AX03
ATC
methotrexate; systemic
17.8
113.5
120
124
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
34.9
112.0
76
31
M48.0
ICD-10 Finland
Spinal stenosis
78.8
110.2
60
10
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
60.6
104.8
60
13
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
50.2
101.9
61
16
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
18.5
100.8
96
82
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
225.6
99.6
97
7
L04AA01
ATC
[U] ciclosporin
63.9
90.4
51
10
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
49.0
90.1
54
14
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
49.4
80.5
48
12
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
329.5
73.7
71
*
NAG42
NOMESCO Finland
Posterior fusion of cervical spine with or without fixation
+∞
71.4
65
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
17.6
69.0
62
46
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
21.3
67.2
54
32
L04AX01
ATC
azathioprine; systemic
18.1
58.8
51
35
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
16.6
58.1
53
40
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
150.5
56.6
58
5
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
21.8
53.7
42
23
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
24.8
51.6
38
18
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
9.3
48.5
69
99
N03AX12
ATC
[U] gabapentin; oral
8.1
47.9
80
138
N02AX02
ATC
tramadol; systemic, rectal
6.5
47.0
164
571
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
8.6
45.6
69
106
M01CB01
ATC
sodium aurothiomalate; parenteral
115.4
44.5
47
5
N03AX16
ATC
[U] pregabalin
6.6
44.2
97
220
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
10.9
43.6
52
59
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
258.7
43.4
43
*
NDG30
NOMESCO Finland
Fusion of wrist, total
177.3
43.3
44
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
7.3
42.1
77
145
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
9.7
41.7
55
71
NA1AD
NOMESCO Finland
Cervical spine CT examination
13.8
41.4
41
35
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.7
40.5
59
86
M05BA07
ATC
risedronic acid; oral
15.4
39.1
36
27
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
11.0
38.6
45
49
H02AB06
ATC
prednisolone; systemic
6.0
38.1
184
801
TQW40
NOMESCO Finland
Remowal of suture of skin
8.4
37.8
56
83
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
7.8
37.5
60
97
M54.2
ICD-10 Finland
Cervicalgia
9.6
36.3
47
59
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
13.9
35.8
35
29
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
209.5
35.8
36
*
M43.1
ICD-10 Finland
Spondylolisthesis
108.3
34.8
37
*
H02AB04
ATC
methylprednisolone; systemic
5.9
34.0
78
180
M05BA04
ATC
alendronic acid; oral
6.6
33.5
64
124
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
12.2
33.0
35
33
M05BX04
ATC
denosumab; parenteral
8.8
32.5
45
61
NF1AA
NOMESCO Finland
Hip X-ray examination
7.2
32.5
55
94
SPAT1229
SPAT
Assessment of need for aid
8.2
31.8
47
69
L04AB01
ATC
etanercept; parenteral
98.1
31.6
34
*
M01AX01
ATC
nabumetone; oral
10.9
31.4
36
38
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.6
30.9
149
616
M01AB55
ATC
diclofenac, combinations; oral
8.5
30.3
43
60
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
57.9
30.3
35
7
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
75.7
29.7
33
5
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
13.0
29.7
30
26
H02AB08
ATC
triamcinolone; systemic
328.4
29.4
29
*
9522
FHL
Synovectomy
169.8
29.3
30
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
40.4
28.3
35
10
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
163.4
28.3
29
*
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
12.5
28.1
29
26
L28
ICPC
Limited function/disability (L)
4.8
27.6
80
222
NHM20
NOMESCO Finland
Excision of synovial ganglion of ankle or foot
39.1
27.3
34
10
7140B
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]
157.1
27.2
28
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
7.1
27.0
45
75
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
58.7
26.9
31
6
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
8.5
26.6
37
50
H02AB07
ATC
prednisone; oral
5.1
26.6
68
170
M01AH01
ATC
celecoxib; oral
4.7
26.5
78
219
9503
FHL
Tendon or tendon sheath cleansing surgery (tenosynovectomy)
289.1
26.2
26
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
7.1
25.5
42
69
9284
FHL
Wrist ossification surgery
+∞
25.4
24
*
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
25.4
24
*
WX204
NOMESCO Finland
Axillary plexus blockaced
11.1
25.2
28
28
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
+∞
24.4
23
*
9527
FHL
Alloarthroplasty, implant or endoprosthesis
+∞
24.4
23
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
264.5
24.1
24
*
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
138.4
24.1
25
*
N02AA05
ATC
oxycodone; systemic
4.4
23.4
76
228
NCB20
NOMESCO Finland
Primary total prosthetic replacement of elbow joint
+∞
23.3
22
*
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
9.5
23.2
29
34
M54.4
ICD-10 Finland
Lumbago with sciatica
5.5
23.2
51
111
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
92.4
23.1
25
*
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
22.2
22.9
33
17
SPAT1148
SPAT
Treatment of chronic ulcer or burn
4.9
22.7
60
153
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
4.5
22.6
68
192
NDG76
NOMESCO Finland
Fusion of DIP joint
57.8
22.6
26
5
ZZH31
NOMESCO Finland
Bone allograft, small pieces
88.3
22.1
24
*
9531
FHL
Arthrodesis of the hand joint
240.3
22.0
22
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
126.2
22.0
23
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.6
21.8
140
660
7230B
ICD-9 Finland
Other disorders of cervical region, Spinal stenosis of cervical region[SUBLUXATIO ATLANTO-AXIALIS]
+∞
21.1
20
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.9
21.1
42
83
S97
ICPC
Chronic ulcer skin
6.7
21.1
36
61
J01FF01
ATC
clindamycin; systemic
3.6
21.0
104
414
M01CB03
ATC
auranofin; oral
228.4
20.9
21
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
7.8
20.4
30
43
L04AB04
ATC
adalimumab; parenteral
39.5
20.3
25
7
9283
FHL
Subtalar joint ossification surgery (or triple)
+∞
20.1
19
*
NHG20
NOMESCO Finland
Fusion of talocrural joint
60.0
19.3
22
*
M43.0
ICD-10 Finland
Spondylolysis
204.8
18.8
19
*
M81.9
ICD-10 Finland
Osteoporosis, unspecified
7.0
18.5
30
48
R4120
NOMESCO Finland
Occupational therapy
5.8
18.3
36
70
A02BC01
ATC
omeprazole; systemic
3.3
18.1
98
406
X59
ICD-10 Finland
Exposure to unspecified factor
3.7
17.8
71
242
NDG74
NOMESCO Finland
Fusion of first IP joint
193.2
17.8
18
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.5
17.6
79
291
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
45.7
17.6
21
5
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
45.7
17.6
21
5
L04AA24
ATC
abatacept; parenteral
96.7
16.8
18
*
L04AA11
ATC
[U] etanercept
181.7
16.7
17
*
NDG77
NOMESCO Finland
Other excision, reconstruction or fusion of joint of first finger
181.7
16.7
17
*
N02BF02
ATC
pregabalin; oral
7.7
16.4
24
34
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
13.6
16.3
28
23
M01AH02
ATC
rofecoxib; oral
4.0
16.0
53
158
NDB78
NOMESCO Finland
Prosthetic replacement of several of finger or metacarpal
+∞
15.8
15
*
9256
FHL
Synovectomy (knee 9311)
+∞
15.8
15
*
M01CC01
ATC
penicillamine; oral
+∞
15.8
15
*
NDB60
NOMESCO Finland
Prosthetic replacement of MCP joint of finger
+∞
15.8
15
*
NDC40
NOMESCO Finland
Secondary prosthetic replacement in of joint of finger or metacarpal
+∞
15.8
15
*
N06AX21
ATC
duloxetine; oral
4.9
15.6
38
89
M54.9
ICD-10 Finland
Dorsalgia, unspecified
5.2
15.5
34
73
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.0
15.5
99
446
NH1AD
NOMESCO Finland
Ankle and foot CT
18.0
15.1
23
14
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
34.1
15.0
19
6
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
3.9
14.8
50
151
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
13.8
14.7
25
20
9272
FHL
Metatarsophalangeal joint resection
85.3
14.7
16
*
WX203
NOMESCO Finland
Infraclavicular plexus blockade
16.8
14.7
23
15
9294
FHL
Endoprosthesis replacement of the entire hip joint (eg Charnley)
38.6
14.7
18
5
A02BC03
ATC
lansoprazole; oral
3.0
14.6
96
436
9289
FHL
Other measure in this category
159.0
14.6
15
*
ZXA05
NOMESCO Finland
Left side
3.0
14.6
88
381
N02BF01
ATC
gabapentin; oral
5.8
14.6
28
53
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
29.2
14.5
19
7
NDL52
NOMESCO Finland
Tenosynovectomy of hand
24.0
14.5
20
9
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
5.5
14.5
30
61
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.9
14.3
49
149
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
45.3
14.3
17
*
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
79.6
13.7
15
*
M05BA01
ATC
etidronic acid; systemic
79.6
13.7
15
*
L01BB01, ,
ATC
79.6
13.7
15
*
L04AA17
ATC
[U] adalimumab
79.6
13.7
15
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
17.5
13.7
21
13
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
13.7
138
778
M53.2
ICD-10 Finland
Spinal instabilities
+∞
13.7
13
*
9260
FHL
Alloarthroplasty, endoprosthesis or implant
+∞
13.7
13
*
WZA90
NOMESCO Finland
Other medical or dental certificate
3.0
13.6
79
333
NDF60
NOMESCO Finland
Operation for osteochondritis of a joint of hand,v
147.8
13.6
14
*
3006
Kela drug reimbursment
Baricitinib
147.8
13.6
14
*
M47.9
ICD-10 Finland
Spondylosis, unspecified
147.8
13.6
14
*
TNG10
NOMESCO Finland
Puncture of knee
22.7
13.6
19
9
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
6.8
13.5
22
35
ZX120
NOMESCO Finland
Intravenous
4.0
13.5
42
119
M01AE03
ATC
ketoprofen; systemic, rectal
2.7
13.4
114
589
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
5.9
13.4
25
46
SPAT1215
SPAT
Assessment of need for medical rehabilitation
6.6
13.2
22
36
X58
ICD-10 Finland
Exposure to other specified factors
3.6
13.1
50
163
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
24.1
13.1
18
8
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
52.9
13.0
15
*
M54.5
ICD-10 Finland
Low back pain
2.9
13.0
80
348
A02BC02
ATC
pantoprazole; systemic
3.1
12.9
193
1315
B01AB05
ATC
enoxaparin; parenteral
2.7
12.9
107
543
L01
ICPC
Neck symptom/complaint
3.5
12.9
52
176
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.8
12.8
89
412
Z50.1
ICD-10 Finland
Other physical therapy
5.5
12.7
26
52
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.6
12.7
126
697
ZXA00
NOMESCO Finland
Right side
2.8
12.7
90
421
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
+∞
12.6
12
*
M05.3
ICD-10 Finland
Rheumatoid arthritis with involvement of other organs and systems
+∞
12.6
12
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
9.8
12.6
25
28
293
Kela drug reimbursment
Baricitinib
136.6
12.6
13
*
M45
ICD-10 Finland
Ankylosing spondylitis
136.6
12.6
13
*
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
15.4
12.5
20
14
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.8
12.5
43
131
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
19.3
12.2
18
10
ZXE20
NOMESCO Finland
More than three and less than five hours
3.3
12.2
54
193
L04AB06
ATC
golimumab; parenteral
49.2
12.0
14
*
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
49.2
12.0
14
*
M79.6
ICD-10 Finland
Pain in limb
2.6
12.0
116
630
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
3.1
11.9
61
238
WZA10
NOMESCO Finland
Extensive medical or dental certificate
20.2
11.8
17
9
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.2
11.7
34
91
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.7
11.7
89
429
9165
FHL
Removal of osteosynthesis material
14.6
11.7
19
14
H04.10
ICD-10 Finland
Dry eye syndrome
3.5
11.7
46
153
M01AB01
ATC
indometacin; systemic, rectal
4.6
11.6
29
69
WX707
NOMESCO Finland
Fiberoscopic intubation
+∞
11.5
11
*
L04AC07
ATC
tocilizumab; parenteral
+∞
11.5
11
*
L04AA37
ATC
[U] baricitinib
125.6
11.5
12
*
NCF10
NOMESCO Finland
Synovectomy of elbow joint, open
125.6
11.5
12
*
NHG82
NOMESCO Finland
Fusion of other tarsal joint
16.1
11.5
18
12
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
5.1
11.5
25
53
M01AX17
ATC
nimesulide; oral
2.7
11.4
78
356
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
21.3
11.3
16
8
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
26.5
11.3
15
6
NG1DA
NOMESCO Finland
X-ray of knees
26.5
11.3
15
6
J01MA12
ATC
levofloxacin; systemic
3.0
11.3
61
245
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
11.1
76
346
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.4
11.0
44
147
R06.0
ICD-10 Finland
Dyspnoea
2.6
11.0
86
418
R50.9
ICD-10 Finland
Fever, unspecified
3.1
11.0
54
205
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.6
11.0
40
126
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.9
10.8
62
257
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
10.8
45
155
P01BA01
ATC
chloroquine; systemic
62.8
10.7
12
*
9477
FHL
Cleansing or splitting of a tendon or tendon sheath (eg tenosynovectomy, tenolysis)
62.8
10.7
12
*
WX002
NOMESCO Finland
Sedation and analgesia
2.8
10.6
65
279
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
10.6
57
228
NH3EA
NOMESCO Finland
Feet X-ray examination with load
12.8
10.5
18
15
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
10.5
134
812
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.1
10.5
31
84
L04AB05
ATC
certolizumab pegol; parenteral
114.7
10.5
11
*
ZXM20
NOMESCO Finland
Intraoperative use of computerised tomography
114.7
10.5
11
*
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
114.7
10.5
11
*
RT271, ,
NOMESCO Finland
114.7
10.5
11
*
M01AC06
ATC
meloxicam; systemic, rectal
2.4
10.4
108
596
NK4AT
NOMESCO Finland
Puncture of joint with ultrasound guidance not elsewher classified
34.1
10.4
13
*
S18
ICPC
Laceration/cut
2.4
10.4
127
755
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
4.3
10.4
28
71
D06BB04
ATC
podophyllotoxin; topical
5.6
10.3
20
38
J01MA02
ATC
ciprofloxacin; systemic
2.4
10.3
111
624
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
15.4
10.1
16
11
M03BX01
ATC
baclofen; systemic
12.9
10.0
17
14
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
17.6
10.0
15
9
NB2AT
NOMESCO Finland
Intra artrial injection of shoulder with ultrasound guidance
17.6
10.0
15
9
B01AB04
ATC
dalteparin; parenteral
5.2
10.0
21
43
9271
FHL
Hallux surgery
11.3
10.0
18
17
NBB20
NOMESCO Finland
Primary total prosthetic replacement of humero-scapular joint
11.3
10.0
18
17
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.5
9.9
37
118
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.0
9.7
51
200
JN3AD
NOMESCO Finland
Abdominal CT examination
3.4
9.7
38
125
L01AA02
ATC
chlorambucil; oral
57.3
9.7
11
*
TNC11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in elbow joint
57.3
9.7
11
*
NGC30
NOMESCO Finland
Secondary implantation of prosthesis in knee joint, special prosthesis
57.3
9.7
11
*
NHB10
NOMESCO Finland
Primary partial prosthetic replacement of ankle joint
57.3
9.7
11
*
SPAT1153
SPAT
Removal of sutures
2.4
9.7
93
493
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
10.7
9.7
18
18
M01AH05
ATC
etoricoxib; oral
2.4
9.7
158
1053
N02AJ06
ATC
codeine and paracetamol; systemic
2.3
9.7
113
653
A02BC05
ATC
esomeprazole; systemic
2.3
9.6
114
662
J04AB02
ATC
rifampicin; systemic
31.4
9.5
12
*
J01DB01
ATC
cefalexin; oral
3.2
9.5
216
1676
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
103.8
9.5
10
*
291
Kela drug reimbursment
Tofacitinib
103.8
9.5
10
*
A02BB01
ATC
misoprostol; oral
103.8
9.5
10
*
9314
FHL
Total knee endoprosthesis (also includes patellar part)
103.8
9.5
10
*
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
9.4
9
*
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
+∞
9.4
9
*
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
+∞
9.4
9
*
K07.60
ICD-10 Finland
Snapping jaw
4.6
9.3
23
54
ZZH20
NOMESCO Finland
Graft of patients own bone
38.2
9.1
11
*
9473
FHL
Local soft tissue removal or exploration (eg Bursa)
38.2
9.1
11
*
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
38.2
9.1
11
*
NBB10
NOMESCO Finland
Primary partial prosthetic replacement of humero-scapular joint not using cement, other or unspecified
19.5
9.0
13
7
SPAT1149
SPAT
Suture or treatment of traumatic wound
3.1
8.9
41
149
J20
ICD-10 Finland
Acute bronchitis
3.3
8.9
36
121
N06AA09
ATC
amitriptyline; systemic
3.6
8.8
31
95
J01DA01
ATC
[U] cefalexin
2.3
8.8
164
1136
B02.9
ICD-10 Finland
Zoster without complication
3.7
8.8
30
90
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.9
8.7
27
76
M05BA06
ATC
ibandronic acid; systemic
7.8
8.6
19
26
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
7.2
8.6
20
30
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
28.6
8.6
11
*
R51.80
ICD-10 Finland
Headache
2.9
8.5
46
183
NDF68
NOMESCO Finland
Operation for osteochondritis of several joints of hand, open
93.1
8.5
9
*
L04AC14
ATC
sarilumab; systemic
93.1
8.5
9
*
3029
Kela drug reimbursment
Upadacitinib
93.1
8.5
9
*
NDG71
NOMESCO Finland
Arthrodes of first MP joint
93.1
8.5
9
*
298, ,
Kela drug reimbursment
93.1
8.5
9
*
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
10.0
8.4
16
17
NB1AD
NOMESCO Finland
Shoulder CT examination
10.0
8.4
16
17
NDL99
NOMESCO Finland
Other operation on muscle or tendon of wrist or hand
+∞
8.4
8
*
L04AA29
ATC
[U] tofacitinib
+∞
8.4
8
*
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
8.4
8
*
M03BX02
ATC
tizanidine; oral
2.2
8.4
153
1043
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.8
8.4
27
78
R52.2
ICD-10 Finland
Other chronic pain
8.0
8.3
18
24
A28
ICPC
Limited function/disability NOS
2.6
8.2
53
231
N03AE01
ATC
clonazepam; systemic
4.4
8.2
21
51
ZX140
NOMESCO Finland
Intra articular
17.9
8.2
12
7
M35.7
ICD-10 Finland
Hypermobility syndrome
34.6
8.1
10
*
NDF10
NOMESCO Finland
Synovectomy of wrist
34.6
8.1
10
*
NFC40
NOMESCO Finland
Repair of hip prosthesis by bone transplant to acetabulum
34.6
8.1
10
*
NDL66
NOMESCO Finland
Transposition of tendon of wrist or hand, other tendon
34.6
8.1
10
*
L04AK01
ATC
leflunomide; oral
34.6
8.1
10
*
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
7.7
8.1
18
25
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
22.9
8.1
11
5
M54.3
ICD-10 Finland
Sciatica
7.0
8.1
19
29
M01AE02
ATC
naproxen; oral, rectal
2.2
8.1
152
1043
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.6
8.0
51
221
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
11.3
7.9
14
13
WX320
NOMESCO Finland
Spinalanesthesy
2.3
7.9
77
406
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
7.8
7.8
17
23
L04AD01
ATC
ciclosporin; systemic
15.7
7.8
12
8
XX9XE
NOMESCO Finland
Other ultrasound examination
15.7
7.8
12
8
L95
ICPC
Osteoporosis
4.8
7.8
18
40
M03BC01
ATC
orphenadrine (citrate); systemic
2.5
7.8
59
278
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
7.8
93
533
M05BX03
ATC
strontium ranelate; oral
46.5
7.8
9
*
NF2AT
NOMESCO Finland
Injection to hip joint with ultrasound guidance
46.5
7.8
9
*
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
7.1
7.7
18
27
WX110
NOMESCO Finland
Infiltration anesthesia
2.3
7.7
180
1333
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.2
7.7
32
109
L17
ICPC
Foot/toe symptom/complaint
2.2
7.7
85
471
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
19.1
7.7
11
6
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
19.1
7.7
11
6
UKC02
NOMESCO Finland
Cystoscopy
2.8
7.7
42
168
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.5
7.7
28
88
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.8
7.6
42
169
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.1
7.6
115
721
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.9
7.5
23
64
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
3.9
7.5
23
64
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
13.9
7.5
12
9
NDM99
NOMESCO Finland
Other operation on fascia, ganglion, synovial sheath or bursa of wrist or hand
82.5
7.5
8
*
ZZH40
NOMESCO Finland
Substitute of bone
82.5
7.5
8
*
L04AA44
ATC
[U] upadacitinib
82.5
7.5
8
*
H02BX01
ATC
methylprednisolone, combinations; systemic
4.4
7.4
19
46
R4180
NOMESCO Finland
Podiatric therapy
11.4
7.4
13
12
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.5
7.3
26
80
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
+∞
7.3
7
*
9311
FHL
Knee cleansing surgery (synovectomy, debridement)
+∞
7.3
7
*
E85.3
ICD-10 Finland
Secondary systemic amyloidosis
+∞
7.3
7
*
L01CB
ATC
Podophyllotoxin derivatives
+∞
7.3
7
*
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
+∞
7.3
7
*
L03
ICPC
Low back symptom/complaint
2.3
7.3
63
314
SPAT1216
SPAT
Assessment of functional ability
2.6
7.2
48
212
M17.4
ICD-10 Finland
Other secondary gonarthrosis, bilateral
31.0
7.2
9
*
L83
ICPC
Neck syndrome
31.0
7.2
9
*
ZXC95
NOMESCO Finland
Use of surgical navigator
31.0
7.2
9
*
H05AA02
ATC
teriparatide; parenteral
20.7
7.2
10
5
318
Kela drug reimbursment
Teriparatide
20.7
7.2
10
5
M50.3
ICD-10 Finland
Other cervical disc degeneration
20.7
7.2
10
5
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
20.7
7.2
10
5
Z2446
NOMESCO Finland
Social worker
3.6
7.2
24
71
UJF32
NOMESCO Finland
Coloscopy
2.3
7.2
71
375
N43.3
ICD-10 Finland
Hydrocele, unspecified
12.5
7.2
12
10
L99
ICPC
Musculoskeletal disease other
9.2
7.1
14
16
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
7.4
7.1
16
23
N02AC04
ATC
dextropropoxyphene; oral
7.4
7.1
16
23
L16
ICPC
Ankle symptom/complaint
2.9
7.1
35
132
M05BB03
ATC
alendronic acid and colecalciferol; oral
6.2
7.1
18
31
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.2
7.0
81
454
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.8
7.0
37
145
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
6.9
49
223
G44.2
ICD-10 Finland
Tension-type headache
2.7
6.9
40
165
S72.3
ICD-10 Finland
Fracture of shaft of femur
17.3
6.8
10
6
7148X
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Other specified inflammatory polyarthropathies
41.2
6.8
8
*
RT272, ,
NOMESCO Finland
41.2
6.8
8
*
R13
ICD-10 Finland
Dysphagia
3.4
6.8
25
79
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.2
6.7
18
45
M02AA10
ATC
ketoprofen; topical
2.5
6.6
45
200
WZC00
NOMESCO Finland
Treatment plan or consultation
2.0
6.6
97
593
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.6
6.6
22
65
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
7.7
6.5
14
19
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
3.4
6.5
24
76
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
6.5
101
631
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
6.5
85
499
NHF80
NOMESCO Finland
Operation for debridement of toe joint, open
71.6
6.5
7
*
3005
Kela drug reimbursment
Tofacitinib
71.6
6.5
7
*
ZZH32
NOMESCO Finland
Bone allograft, block
71.6
6.5
7
*
0103, ,
NOMESCO Finland
71.6
6.5
7
*
7143B
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[POLYARTHRITIS JUVENILIS SEROPOSITIVA]
71.6
6.5
7
*
M81.8
ICD-10 Finland
Other osteoporosis
14.8
6.4
10
7
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.6
6.4
22
66
M19.2
ICD-10 Finland
Other secondary arthrosis
9.6
6.4
12
13
Z3226
NOMESCO Finland
Physiotherapist
2.3
6.4
52
252
ND1AA
NOMESCO Finland
Wrist X-ray examination
3.1
6.3
28
99
AA1AD
NOMESCO Finland
CT of head and brain
2.1
6.3
71
392
1222
FHL
Arthroscopy and synovial surgery
18.6
6.3
9
5
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
3.7
6.3
20
57
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.2
6.3
25
83
9508
FHL
Tendon or muscle transposition
+∞
6.3
6
*
M50.9
ICD-10 Finland
Cervical disc disorder, unspecified
+∞
6.3
6
*
NCF20
NOMESCO Finland
Operation for osteochondritis of elbow joint, open
+∞
6.3
6
*
NAU20
NOMESCO Finland
Removal of internal fixation device from spine or neck
+∞
6.3
6
*
NDG79
NOMESCO Finland
Other excision, reconstruction or fusion of joint of II-V finger
+∞
6.3
6
*
Z98.1
ICD-10 Finland
Arthrodesis status
+∞
6.3
6
*
6960A
ICD-9 Finland
Psoriasis and similar disorders, Psoriatic arthropathy
+∞
6.3
6
*
NCM20
NOMESCO Finland
Excision of synovial ganglion of elbow or forearm
27.4
6.3
8
*
M81.4
ICD-10 Finland
Drug-induced osteoporosis
27.4
6.3
8
*
L01AA01
ATC
cyclophosphamide; systemic
27.4
6.3
8
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.4
6.2
45
206
N30.0
ICD-10 Finland
Acute cystitis
2.4
6.2
45
206
ZXD05
NOMESCO Finland
Urgent procedure
2.1
6.2
82
481
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
8.0
6.2
13
17
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
8.0
6.2
13
17
-, ,
ICD-10 Finland
8.0
6.2
13
17
KFD20
NOMESCO Finland
Excision of hydrocele of testis
13.0
6.1
10
8
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.0
6.1
28
101
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
6.1
69
382
EBA05
NOMESCO Finland
Complicated extraction of tooth
2.2
6.0
62
330
M54.8
ICD-10 Finland
Other dorsalgia
7.6
6.0
13
18
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
46
37
15.04
48.30
2.2
1.5
15015.82
22367.15
e6/l
0.18
34
27
43
43
11.89
39.17
1.9
1.3
—
—
—
0
0
35
57
6.99
21.28
1.8
1.4
2.51
0.00
iu/ml
—
8
10
169
909
3.70
21.11
15.8
5.6
59.74
57.16
%
1.76
164
866
157
818
3.51
20.39
3.1
2.2
80.02
78.04
nmol/l
0.34
144
725
187
1108
3.80
19.33
18.8
9.4
4.42
4.01
e9/l
1.98
182
969
105
459
3.23
17.68
2.7
2.1
3.64
3.21
mg/l
1.07
94
388
216
1475
4.60
16.63
13.5
3.7
14.83
12.19
mm/h
1.69
210
1331
23
33
7.58
15.54
1.8
1.5
—
—
—
0
0
152
936
2.61
12.07
7.5
3.4
0.00
0.00
estimate
-0.00
47
198
210
1529
3.44
11.97
14.1
7.2
72.40
78.46
u/l
1.89
203
1421
145
876
2.58
11.94
5.9
5.8
1.21
1.22
mmol/l
0.47
132
801
152
949
2.55
11.53
7.7
3.5
0.00
0.02
estimate
0.50
43
178
153
962
2.54
11.37
7.3
6.7
1.21
1.22
mmol/l
0.17
128
820
151
944
2.53
11.35
9.8
4.8
0.00
0.00
estimate
-0.00
45
183
145
912
2.42
10.44
3.4
2.4
—
—
—
0
0
65
288
2.70
9.90
1.9
1.9
—
—
—
0
0
165
1124
2.40
9.56
5.1
4.4
6.29
6.69
mmol/l
2.61
159
1038
18
19
10.12
9.44
1.1
1.0
—
—
—
0
0
73
352
2.52
9.30
1.8
1.6
1031.86
1133.83
nmol/l
0.43
56
255
116
708
2.20
8.41
4.4
3.6
3547.57
44.86
ng/l
0.49
89
507
47
197
2.71
7.86
3.9
7.3
1.26
1.46
mmol/l
0.08
38
166
125
803
2.12
7.77
3.4
2.6
100.42
118.12
ug/l
0.69
120
738
88
508
2.14
7.10
8.5
3.6
0.00
0.01
estimate
0.50
45
188
83
471
2.15
6.98
2.9
2.2
—
—
—
0
0
34
129
2.90
6.82
1.8
1.4
—
—
—
0
0
132
907
1.97
6.42
13.5
11.7
1.22
1.26
inr
0.21
38
296
112
735
1.96
6.17
8.4
3.6
—
—
—
0
0
71
399
2.09
6.01
8.0
3.5
1.01
1.02
kg/l
—
10
57
17
35
5.14
5.86
5.6
2.6
5.37
4.15
e9/l
1.65
17
35
11
12
9.53
5.85
1.5
1.5
—
—
—
0
0
17
36
4.99
5.73
5.6
3.0
66.76
58.31
%
1.87
17
36
43
206
2.32
5.36
3.2
3.0
—
—
—
0
0
17
49
3.65
5.27
1.7
1.4
—
—
—
0
0
16
45
3.73
5.14
1.3
1.4
—
—
—
0
0
28
112
2.69
5.08
1.8
1.6
—
—
—
0
0
90
581
1.86
4.98
3.0
3.2
1290.37
1160.02
ng/l
0.16
81
492
57
315
2.05
4.97
1.2
1.2
80.04
37.29
iu/ml
1.26
30
109
19
63
3.18
4.78
3.2
2.5
—
—
—
0
0
55
304
2.04
4.78
1.2
1.2
154.06
16.73
u/ml
0.80
25
119
88
572
1.83
4.72
2.1
2.3
52.87
65.36
u/l
0.86
83
525
113
792
1.78
4.72
2.2
1.9
91.86
97.21
pmol/l
0.50
58
393
99
673
1.78
4.55
5.8
3.0
—
—
—
0
0
40
199
2.20
4.55
1.9
1.8
—
—
—
0
0
45
235
2.12
4.53
5.0
6.6
104.20
104.44
mmol/l
0.10
45
235
67
417
1.83
4.06
1.7
1.7
404.95
438.92
pmol/l
0.47
58
329
39
201
2.12
4.06
1.8
1.8
—
—
—
0
0
12
27
4.62
3.99
1.4
2.0
—
—
—
0
0
77
503
1.77
3.96
4.9
2.8
0.34
0.47
e6/l
0.24
68
379
18
65
2.91
3.95
2.0
1.7
—
—
—
0
0
26
115
2.41
3.87
4.0
8.6
1.17
1.42
%
0.69
26
115
71
456
1.78
3.86
1.7
1.4
17.20
21.78
nmol/l
2.65
60
379
8
12
6.84
3.70
1.9
1.1
—
—
—
0
0
19
74
2.70
3.64
2.2
2.1
—
—
—
0
0
133
1024
1.64
3.63
4.6
6.2
9.29
10.87
umol/l
2.25
128
974
17
63
2.82
3.57
1.3
1.7
3.08
2.90
g/l
0.29
17
57
18
69
2.73
3.56
1.3
1.7
3.63
3.50
g/l
0.15
18
63
18
69
2.73
3.56
1.3
1.7
7.63
7.22
g/l
0.43
18
63
18
69
2.73
3.56
1.3
1.7
—
—
—
0
0
8
13
6.32
3.53
1.3
1.2
—
—
—
0
0
24
107
2.38
3.51
4.3
9.1
95.63
94.56
%
0.74
24
107
82
566
1.67
3.39
3.1
1.9
144.37
207.20
u/l
0.82
82
531
25
116
2.28
3.36
4.1
8.5
0.62
0.68
%
0.30
25
116
223
2000
2.14
3.33
33.7
12.5
17.39
23.50
mg/l
3.87
212
1528
11
28
4.06
3.33
1.2
1.2
5.83
4.29
u/ml
—
6
14
15
54
2.89
3.32
1.3
1.9
0.00
0.00
g/l
-0.00
15
49
16
61
2.73
3.20
1.6
2.7
—
—
—
0
0
10
25
4.12
3.12
1.5
2.0
—
—
—
0
0
14
51
2.85
3.04
1.8
2.0
—
—
—
0
0
10
26
3.96
3.01
1.0
1.1
—
—
—
0
0
28
143
2.08
2.99
2.1
2.2
7.34
6.96
ug/l
0.05
20
132
12
38
3.27
2.89
1.6
2.2
—
—
—
0
0
25
124
2.13
2.88
4.0
3.4
4.26
4.58
pmol/l
1.00
25
111
16
65
2.56
2.85
1.3
1.7
10.64
10.15
g/l
0.18
16
58
14
53
2.74
2.84
1.8
2.0
—
—
—
0
0
40
236
1.83
2.84
7.3
6.3
—
—
—
0
0
13
48
2.80
2.76
1.2
1.2
—
—
—
0
0
14
54
2.69
2.75
1.4
1.2
—
—
—
0
0
25
127
2.08
2.72
1.2
1.3
130.74
207.86
iu/ml
0.36
11
58
67
471
1.58
2.49
3.2
2.8
6816.80
10026.96
umol/l
0.19
60
415
46
294
1.69
2.49
4.1
2.4
1.28
1.27
e6/l
0.01
31
168
59
403
1.61
2.47
1.8
1.6
1.31
1.25
mg/l
0.10
44
312
21
104
2.11
2.44
1.4
1.2
—
—
—
0
0
89
672
1.51
2.38
2.3
3.4
2.35
2.36
mmol/l
0.55
77
595
11
39
2.90
2.37
1.9
1.9
—
—
—
0
0
11
39
2.90
2.37
1.9
1.9
—
—
—
0
0
6
13
4.70
2.28
1.0
2.3
—
—
—
0
0
6
13
4.70
2.28
1.0
2.3
—
—
—
0
0
6
13
4.70
2.28
1.0
2.3
—
—
—
0
0
8
25
3.27
2.11
1.0
2.0
—
—
—
0
0
8
25
3.27
2.11
1.0
2.0
—
—
—
0
0
8
25
3.27
2.11
1.0
2.0
—
—
—
0
0
45
299
1.62
2.10
4.7
3.3
0.80
0.82
mmol/l
0.64
45
284
12
50
2.47
2.06
1.9
1.9
—
—
—
0
0
10
38
2.70
2.03
2.1
1.9
—
—
—
0
0
13
57
2.35
2.01
1.3
1.8
36.68
38.92
g/l
0.81
13
51
26
150
1.82
2.00
7.2
6.7
6.97
8.73
mmol/l
1.25
26
139
12
51
2.42
1.98
1.3
1.9
0.00
0.00
g/l
-0.00
12
46
6
16
3.81
1.94
1.0
2.1
—
—
—
0
0
6
16
3.81
1.94
1.0
2.1
—
—
—
0
0
12
52
2.37
1.91
1.3
1.9
0.00
0.00
g/l
-0.00
12
47
8
28
2.92
1.88
1.8
2.0
—
—
—
0
0
6
17
3.59
1.85
1.7
1.4
—
—
—
0
0
174
1541
1.43
1.81
4.6
3.9
15.57
14.87
pmol/l
2.72
161
1384
42
287
1.56
1.75
4.5
2.6
4.91
3.10
e6/l
0.57
28
163
12
55
2.24
1.70
1.3
1.8
—
—
—
0
0
5
15
3.38
1.53
1.0
1.0
—
—
—
0
0
5
15
3.38
1.53
1.0
1.1
—
—
—
0
0
13
65
2.06
1.51
1.3
1.2
—
—
—
0
0
6
21
2.90
1.51
1.8
2.1
—
—
—
0
0
24
149
1.68
1.47
3.1
2.8
78.80
60.63
ml/min/173m2
—
10
62
211
1964
1.50
1.46
22.1
12.1
83.92
80.19
ml/min/173m2
1.77
185
1601
6
23
2.65
1.37
2.3
1.7
—
—
—
0
0
5
17
2.98
1.36
1.6
1.2
—
—
—
0
0
6
24
2.54
1.31
1.0
1.0
—
—
—
0
0
8
34
2.40
1.30
1.6
1.9
—
—
—
0
0
5
18
2.81
1.29
1.6
3.6
10.28
3.53
nmol/l
—
5
18
6
25
2.43
1.25
1.0
1.0
—
—
—
0
0
12
63
1.95
1.25
2.2
4.1
1.08
1.36
mmol/l
0.67
12
63
14
78
1.84
1.24
1.6
1.8
—
—
—
0
0
23
149
1.60
1.22
5.6
3.4
4.33
4.52
kpa
0.24
23
141
5
19
2.66
1.22
2.2
2.2
—
—
—
0
0
12
64
1.92
1.20
1.5
1.6
—
—
—
0
0
6
26
2.34
1.19
1.3
1.6
—
—
—
0
0
6
26
2.34
1.19
1.3
1.6
—
—
—
0
0
6
26
2.34
1.19
1.3
1.6
—
—
—
0
0
6
26
2.34
1.19
1.3
1.6
—
—
—
0
0
6
26
2.34
1.19
1.3
1.6
—
—
—
0
0
6
26
2.34
1.19
1.8
2.0
—
—
—
0
0
12
65
1.89
1.15
1.2
1.2
—
—
—
0
0
25
170
1.52
1.10
5.5
4.0
5.88
5.82
kpa
0.15
25
161
5
21
2.41
1.09
2.6
4.1
—
—
—
0
0
7
32
2.22
1.09
1.7
1.9
—
—
—
0
0
227
2173
1.53
1.05
31.5
15.0
73.35
74.95
umol/l
0.33
227
2173
190
1773
1.31
0.99
32.2
15.2
16.37
14.86
%
2.27
190
1738
5
23
2.20
0.98
3.0
1.7
—
—
—
0
0
5
23
2.20
0.98
3.0
1.7
—
—
—
0
0
9
50
1.83
0.97
1.8
1.4
—
—
—
0
0
16
101
1.62
0.96
1.1
1.0
—
—
—
0
0
6
27
2.25
0.94
1.3
1.6
—
—
—
0
0
8
42
1.93
0.89
1.3
1.2
—
—
—
0
0
8
44
1.84
0.86
1.6
1.3
—
—
—
0
0
6
31
1.96
0.85
1.3
1.4
—
—
—
0
0
17
113
1.54
0.84
1.1
1.2
—
60.03
—
0
7
198
1872
1.29
0.83
5.5
4.6
1.81
2.57
mu/l
0.60
182
1681
38
296
1.34
0.83
2.3
1.7
29.55
29.64
s
0.03
38
287
6
32
1.90
0.82
1.0
1.1
—
—
—
0
0
10
58
1.75
0.81
2.3
4.3
3.75
4.02
mmol/l
—
10
58
51
419
1.27
0.77
1.4
1.3
4.74
1.00
u/ml
0.45
24
113
5
24
2.10
0.75
1.2
1.2
—
—
—
0
0
7
42
1.69
0.69
4.1
1.8
—
—
—
0
0
5
27
1.87
0.69
1.0
1.7
—
—
—
0
0
5
27
1.87
0.69
1.0
1.1
—
104.50
—
0
6
20
145
1.41
0.68
2.0
1.9
—
—
—
0
0
39
316
1.28
0.66
1.5
1.4
—
—
—
0
0
35
280
1.29
0.65
4.0
4.3
33.71
32.41
%
0.24
24
178
8
51
1.59
0.61
2.0
1.6
587.75
332.25
mu/l
—
8
44
6
37
1.64
0.56
1.3
1.3
—
—
—
0
0
6
37
1.64
0.56
1.3
1.3
—
—
—
0
0
14
99
1.44
0.55
2.9
2.1
13.81
12.12
nmol/l
0.52
14
92
7
46
1.54
0.48
1.0
1.1
—
—
—
0
0
21
165
1.30
0.47
2.0
2.0
—
—
—
0
0
7
49
1.44
0.46
3.4
3.5
25.57
26.67
mmol/l
—
7
49
127
1189
1.14
0.44
3.0
2.9
—
—
—
0
0
13
96
1.37
0.42
1.3
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.8
—
13.19
—
0
15
0
17
0.00
0.41
0.0
1.0
—
456.67
—
0
12
0
17
0.00
0.41
0.0
1.0
—
43.75
—
0
12
5
34
1.48
0.40
1.2
2.0
—
—
—
0
0
40
354
1.15
0.31
4.2
3.3
240.50
472.53
ng/l
0.43
29
278
7
53
1.33
0.31
1.0
1.1
—
12.00
—
0
10
231
2274
1.23
0.30
42.4
18.7
38.78
39.96
%
1.82
217
2132
8
64
1.26
0.27
1.1
1.2
—
—
—
0
0
24
206
1.18
0.27
1.7
2.1
4.44
9.66
umol/l
2.38
18
177
35
313
1.14
0.25
1.4
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
4.0
—
—
—
0
0
0
11
0.00
0.21
0.0
4.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
200
1964
1.09
0.19
4.1
3.9
1.28
1.24
mmol/l
0.44
186
1774
204
2008
1.09
0.17
4.4
4.4
5.69
5.94
mmol/l
2.87
188
1807
66
629
1.07
0.14
3.7
3.8
11.74
6.78
mg/mmol
0.45
43
382
40
374
1.08
0.14
5.0
4.4
23.11
21.46
%
0.33
27
192
5
44
1.14
0.10
1.4
1.2
1.08
0.91
nmol/l
—
5
34
5
65
0.76
0.08
1.4
1.5
—
—
—
0
0
7
82
0.85
0.07
1.0
2.1
3.69
2.19
mg/l
—
7
62
53
546
0.96
0.06
1.7
1.6
1.62
1.31
mmol/l
1.78
46
449
203
2022
1.02
0.01
4.5
4.3
1.56
1.52
mmol/l
0.66
189
1844
204
2034
1.02
0.00
4.6
4.3
4.67
4.70
mmol/l
0.12
190
1867
190
1897
1.01
0.00
5.8
5.6
38.55
39.67
mmol/mol
1.12
178
1739
207
2075
0.99
0.00
4.9
4.8
2.69
2.77
mmol/l
0.71
192
1891
7
72
0.97
-0.00
1.6
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
8
0.00
-0.00
0.0
2.4
—
103.13
—
0
8
5
50
1.00
-0.00
1.8
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
26.91
—
0
7
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
104.80
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
7
0.00
-0.00
0.0
1.0
—
124.29
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
50
1.00
-0.00
1.6
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
99.86
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint M13_ATLOAXSUBLUX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ATLOAXSUBLUX | 2.573 [2.2, 3.01] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.099 |
During the follow-up period (1.1.1998 — 31.12.2019), 298 out of 797 females with M13_ATLOAXSUBLUX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ATLOAXSUBLUX | 1.478 [1.18, 1.85] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 129 out of 500 males with M13_ATLOAXSUBLUX died.
Mortality risk
Mortality risk for people of age
years, who have M13_ATLOAXSUBLUX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.239% |
| 5 | 1.353% | 1.353% |
| 10 | 3.347% | 3.58% |
| 15 | 6.752% | 6.956% |
| 20 | 11.712% | 11.871% |
Relationships between endpoints
↥Index endpoint: M13_ATLOAXSUBLUX – Atlantoaxial subluxation
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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