No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
239 |
4. Check minimum number of eventsNone |
239 |
5. Include endpointsNone |
239 |
6. Filter based on genotype QC (FinnGen only) |
239 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Atlantoaxial subluxation
based on the number of shared cases.
Similar with more cases:
- Deforming dorsopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1586 | 993 | 576 |
| Only index persons | 1308 | 813 | 495 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 58.59 | 61.59 | 53.21 |
| Only index persons | 56.40 | 59.48 | 51.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 239 | 158 | 81 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | 53.82 | 52.76 | 55.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 211
- Matched controls
- 2111
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M43.4
ICD-10 Finland
Other recurrent atlantoaxial subluxation
+∞
167.9
138
*
M43.3
ICD-10 Finland
Recurrent atlantoaxial subluxation with myelopathy
+∞
106.5
93
*
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
69.0
96.3
109
32
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
40.7
92.9
121
67
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
30.2
89.4
131
108
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
110.3
82.2
86
13
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
25.3
64.5
95
66
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
193.7
57.1
57
*
P01BA02
ATC
hydroxychloroquine; oral
18.8
56.9
94
86
A07EC01
ATC
sulfasalazine; oral, rectal
21.1
56.3
88
69
NAG42
NOMESCO Finland
Posterior fusion of cervical spine with or without fixation
+∞
55.7
51
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
17.3
55.3
95
95
L04AA13
ATC
leflunomide; oral
45.0
54.0
66
21
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
39.5
53.9
68
25
M48.0
ICD-10 Finland
Spinal stenosis
123.5
46.0
48
5
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
74.0
45.8
51
9
L88
ICPC
Rheumatoid/seropositive arthritis
24.8
45.2
65
37
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
16.5
45.1
77
71
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
37.6
44.1
56
20
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
41.1
42.7
53
17
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
45.1
40.3
49
14
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
+∞
37.6
35
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
31.5
37.0
49
20
L04AA01
ATC
[U] ciclosporin; systemic
43.5
36.8
45
13
N02AX02
ATC
tramadol; systemic, rectal
6.5
35.1
141
500
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
22.8
34.9
51
29
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
29.6
32.1
43
18
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
83.3
32.0
35
5
L04AX01
ATC
azathioprine; systemic
21.2
31.5
47
28
M01CB01
ATC
sodium aurothiomalate; parenteral
45.9
31.5
38
10
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.7
30.6
130
465
H02AB06
ATC
prednisolone; systemic
5.8
30.4
153
662
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
21.9
29.9
44
25
NDG30
NOMESCO Finland
Fusion of wrist, total
93.9
29.7
32
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
22.5
28.9
42
23
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
25.6
28.7
40
19
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
13.8
27.7
49
45
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
18.4
26.9
42
28
N03AX16
ATC
pregabalin; oral
6.4
26.5
81
186
NHM20
NOMESCO Finland
Excision of synovial ganglion of ankle or foot
41.5
26.1
32
9
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
80.1
25.5
28
*
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
147.4
25.2
26
*
H02AB08
ATC
triamcinolone; systemic
147.4
25.2
26
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
8.8
24.9
57
85
N03AX12
ATC
gabapentin; oral
7.5
24.8
64
115
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
61.5
23.7
27
5
M43.1
ICD-10 Finland
Spondylolisthesis
61.5
23.7
27
5
7140B
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]
73.6
23.4
26
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
73.6
23.4
26
*
9522
FHL
Synovectomy
94.1
23.2
25
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
8.2
23.0
55
87
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
6.6
22.7
65
134
H02AB04
ATC
methylprednisolone; systemic
6.2
22.4
68
151
ZZH31
NOMESCO Finland
Bone allograft, small pieces
244.2
22.0
22
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
244.2
22.0
22
*
9284
FHL
Wrist ossification surgery
122.1
21.0
22
*
M54.2
ICD-10 Finland
Cervicalgia
13.3
21.0
37
33
NCB20
NOMESCO Finland
Primary total prosthetic replacement of elbow joint
231.8
21.0
21
*
9527
FHL
Alloarthroplasty, implant or endoprosthesis
231.8
21.0
21
*
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
9.2
20.8
45
60
NA1AD
NOMESCO Finland
Cervical spine CT examination
14.7
20.8
35
28
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
8.6
20.7
47
68
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
14.8
20.2
34
27
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
116.0
19.9
21
*
9531
FHL
Arthrodesis of the hand joint
219.7
19.9
20
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
14.8
19.7
33
26
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
7.3
19.3
49
84
TQW40
NOMESCO Finland
Remowal of suture of skin
7.7
19.2
47
76
7230B
ICD-9 Finland
Other disorders of cervical region, Spinal stenosis of cervical region[SUBLUXATIO ATLANTO-AXIALIS]
+∞
19.0
18
*
9503
FHL
Tendon or tendon sheath cleansing surgery (tenosynovectomy)
42.7
19.0
23
6
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
109.9
18.9
20
*
9283
FHL
Subtalar joint ossification surgery (or triple)
207.6
18.8
19
*
NDG76
NOMESCO Finland
Fusion of DIP joint
48.8
18.6
22
5
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
15.1
17.6
29
22
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
9.6
17.4
36
44
M05BA04
ATC
alendronic acid; oral
6.2
17.1
49
98
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
15.2
17.0
28
21
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
16.9
16
*
NHG20
NOMESCO Finland
Fusion of talocrural joint
97.9
16.8
18
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
18.7
16.5
25
15
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
13.8
16.4
28
23
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
51.9
16.3
19
*
M01AX01
ATC
nabumetone; oral
9.8
16.2
33
39
H02AB07
ATC
prednisone; oral
4.9
16.0
57
147
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
172.2
15.7
16
*
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
14.7
15.1
25
19
M05BA07
ATC
risedronic acid; oral
10.1
15.1
30
34
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
61.2
15.0
17
*
M01AH01
ATC
celecoxib; oral (coxibs)
4.2
14.9
65
203
M01AB55
ATC
diclofenac, combinations; oral
6.9
14.8
38
65
N02AA05
ATC
oxycodone; systemic
4.8
14.8
54
142
NDG77
NOMESCO Finland
Other excision, reconstruction or fusion of joint of first finger
+∞
14.8
14
*
L04AB01
ATC
etanercept; parenteral
21.0
14.6
21
11
NF1AA
NOMESCO Finland
Hip X-ray examination
5.8
14.5
43
89
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
6.7
14.5
38
67
L28
ICPC
Limited function/disability (L)
4.4
14.1
56
159
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.1
14.0
117
601
M43.0
ICD-10 Finland
Spondylolysis
57.3
14.0
16
*
M05BX04
ATC
denosumab; parenteral
8.1
13.7
31
44
L01BB01
ATC
NA
149.1
13.6
14
*
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
8.1
13.3
30
42
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
10.1
13.2
26
29
M01CB03
ATC
auranofin; oral
30.6
13.2
17
6
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
15.4
13.1
21
15
M01CC01
ATC
penicillamine; oral
53.5
13.0
15
*
NDG74
NOMESCO Finland
Fusion of first IP joint
53.5
13.0
15
*
9272
FHL
Metatarsophalangeal joint resection
53.5
13.0
15
*
A02BC01
ATC
omeprazole; systemic
3.3
13.0
84
355
J01FF01
ATC
clindamycin; systemic
3.3
12.8
83
350
L04AA11
ATC
[U] etanercept; parenteral
34.4
12.8
16
5
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
34.4
12.8
16
5
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
74.4
12.7
14
*
9289
FHL
Other measure in this category
74.4
12.7
14
*
L04AA17
ATC
[U] adalimumab; parenteral
74.4
12.7
14
*
9260
FHL
Alloarthroplasty, endoprosthesis or implant
+∞
12.6
12
*
M05.3
ICD-10 Finland
Rheumatoid arthritis with involvement of other organs and systems
+∞
12.6
12
*
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
+∞
12.6
12
*
NDC40
NOMESCO Finland
Secondary prosthetic replacement in of joint of finger or metacarpal
137.8
12.6
13
*
NH1AD
NOMESCO Finland
Ankle and foot CT
17.2
12.4
19
12
WX204
NOMESCO Finland
Axillary plexus blockaced
11.1
12.3
23
23
NHG82
NOMESCO Finland
Fusion of other tarsal joint
28.6
12.2
16
6
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
22.9
12.2
17
8
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.7
11.9
35
71
M01AH02
ATC
rofecoxib; oral
4.4
11.9
45
121
9294
FHL
Endoprosthesis replacement of the entire hip joint (eg Charnley)
32.1
11.8
15
5
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
24.6
11.8
16
7
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
4.6
11.7
43
112
A02BC03
ATC
lansoprazole; oral
3.1
11.5
78
336
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
8.9
11.4
24
30
NH3EA
NOMESCO Finland
Feet X-ray examination with load
18.3
11.4
17
10
WZA10
NOMESCO Finland
Long statement of health and health related matters
21.5
11.3
16
8
M54.4
ICD-10 Finland
Lumbago with sciatica
4.9
11.1
37
87
9256
FHL
Synovectomy (knee 9311)
45.9
11.0
13
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
5.0
11.0
36
83
9165
FHL
Removal of osteosynthesis material
13.9
10.9
18
14
M01AE03
ATC
ketoprofen; systemic, rectal
2.8
10.8
95
480
SPAT1229
SPAT
Assessment of need for aid
5.0
10.8
35
80
NDB78
NOMESCO Finland
Prosthetic replacement of several of finger or metacarpal
63.3
10.7
12
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.4
10.7
58
212
A02BC02
ATC
pantoprazole; systemic
2.8
10.5
152
1019
NCF10
NOMESCO Finland
Synovectomy of elbow joint, open
115.5
10.5
11
*
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
+∞
10.5
10
*
M53.2
ICD-10 Finland
Spinal instabilities
+∞
10.5
10
*
NDL52
NOMESCO Finland
Tenosynovectomy of hand
20.0
10.4
15
8
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
24.8
10.4
14
6
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.4
10.2
38
100
NDB60
NOMESCO Finland
Prosthetic replacement of MCP joint of finger
42.2
10.1
12
*
X59
ICD-10 Finland
Exposure to unspecified factor
3.3
10.0
58
220
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
17.8
10.0
15
9
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
7.0
9.9
24
38
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
7.0
9.9
24
38
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
9.9
112
642
3006
Kela drug reimbursment
Baricitinib
57.7
9.7
11
*
M54.9
ICD-10 Finland
Dorsalgia, unspecified
6.4
9.7
25
43
TNG10
NOMESCO Finland
Puncture of knee
16.0
9.7
15
10
B01AB05
ATC
enoxaparin; parenteral
2.7
9.6
85
421
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
7.5
9.6
22
32
TPH04
NOMESCO Finland
Cathetrisation of vein
3.1
9.6
60
241
S97
ICPC
Chronic ulcer skin
6.3
9.6
25
44
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
18.6
9.5
14
8
M05BA01
ATC
etidronic acid; systemic
31.6
9.5
12
*
ZXM20
NOMESCO Finland
Intraoperative use of computerised tomography
104.5
9.5
10
*
L01AA02
ATC
chlorambucil; oral
+∞
9.4
9
*
9477
FHL
Cleansing or splitting of a tendon or tendon sheath (eg tenosynovectomy, tenolysis)
+∞
9.4
9
*
M45
ICD-10 Finland
Ankylosing spondylitis
+∞
9.4
9
*
M81.9
ICD-10 Finland
Osteoporosis, unspecified
7.3
9.4
22
33
NE1AA
NOMESCO Finland
Pelvis X-ray examination
5.3
9.3
28
59
X58
ICD-10 Finland
Exposure to other specified factors
3.7
9.3
43
138
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
9.2
77
370
NDF60
NOMESCO Finland
Operation for osteochondritis of a joint of hand,v
38.5
9.1
11
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.5
9.1
101
567
M47.9
ICD-10 Finland
Spondylosis, unspecified
25.3
9.0
12
5
NBB10
NOMESCO Finland
Primary partial prosthetic replacement of humero-scapular joint not using cement, other or unspecified
25.3
9.0
12
5
WX203
NOMESCO Finland
Infraclavicular plexus blockade
10.2
9.0
17
18
M01AB01
ATC
indometacin; systemic, rectal
5.3
8.9
27
57
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.4
8.8
45
156
M03BC01
ATC
orphenadrine (citrate); systemic
3.1
8.8
53
207
L04AA37
ATC
baricitinib; oral
52.2
8.7
10
*
293
Kela drug reimbursment
Baricitinib
52.2
8.7
10
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
9.6
8.7
17
19
NBB20
NOMESCO Finland
Primary total prosthetic replacement of humero-scapular joint
17.2
8.7
13
8
XX9XE
NOMESCO Finland
Other ultrasound examination
28.8
8.6
11
*
9473
FHL
Local soft tissue removal or exploration (eg Bursa)
28.8
8.6
11
*
P01BA01
ATC
chloroquine; systemic
28.8
8.6
11
*
R52.2
ICD-10 Finland
Other chronic pain
13.5
8.5
14
11
M50.3
ICD-10 Finland
Other cervical disc degeneration
93.6
8.5
9
*
NDL66
NOMESCO Finland
Transposition of tendon of wrist or hand, other tendon
93.6
8.5
9
*
NDF10
NOMESCO Finland
Synovectomy of wrist
93.6
8.5
9
*
ZXA05
NOMESCO Finland
Left side
2.6
8.5
73
353
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
8.4
8
*
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
+∞
8.4
8
*
ZX120
NOMESCO Finland
Intravenous
3.9
8.3
34
98
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
8.2
64
292
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.6
8.2
72
351
A02BB01
ATC
misoprostol; oral
34.8
8.1
10
*
ZX140
NOMESCO Finland
Intra articular
23.1
8.1
11
5
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.3
8.1
108
653
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
13.7
8.0
13
10
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
13.7
8.0
13
10
SPAT1215
SPAT
Assessment of need for medical rehabilitation
7.5
8.0
18
26
L04AB04
ATC
adalimumab; parenteral
10.0
7.9
15
16
R06.0
ICD-10 Finland
Dyspnoea
2.6
7.9
64
299
ZXA00
NOMESCO Finland
Right side
2.5
7.9
74
374
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
7.8
83
447
WX002
NOMESCO Finland
Sedation and analgesia
2.8
7.8
58
254
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
7.2
7.8
18
27
WX320
NOMESCO Finland
Spinalanesthesy
2.6
7.8
63
292
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
46.7
7.8
9
*
RT271
NOMESCO Finland
NA
46.7
7.8
9
*
WX707
NOMESCO Finland
Fiberoscopic intubation
46.7
7.8
9
*
M54.5
ICD-10 Finland
Low back pain
2.7
7.8
61
279
L04AA24
ATC
abatacept; parenteral
19.2
7.7
11
6
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
19.2
7.7
11
6
NGC30
NOMESCO Finland
Secondary implantation of prosthesis in knee joint, special prosthesis
19.2
7.7
11
6
M05BA06
ATC
ibandronic acid; systemic
9.4
7.7
15
17
N02AC04
ATC
dextropropoxyphene; oral
9.4
7.7
15
17
9314
FHL
Total knee endoprosthesis (also includes patellar part)
26.1
7.6
10
*
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
5.3
7.5
22
45
R4120
NOMESCO Finland
Occupational therapy
4.5
7.5
26
64
M01AH05
ATC
etoricoxib; oral
2.2
7.5
128
860
TNC11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in elbow joint
82.8
7.5
8
*
NHB10
NOMESCO Finland
Primary partial prosthetic replacement of ankle joint
82.8
7.5
8
*
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
7.3
7.5
17
25
M54.3
ICD-10 Finland
Sciatica
8.9
7.5
15
18
J01MA12
ATC
levofloxacin; systemic
2.8
7.4
52
222
Z50.1
ICD-10 Finland
Other physical therapy
5.2
7.4
22
46
M01AC06
ATC
meloxicam; systemic, rectal
2.3
7.3
85
475
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
+∞
7.3
7
*
9252
FHL
Plaster bandage placement or replacement (no fracture) in the operating room
+∞
7.3
7
*
0103
NOMESCO Finland
NA
+∞
7.3
7
*
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
7.3
7
*
A28
ICPC
Limited function/disability NOS
3.1
7.3
41
151
J01DB01
ATC
cefalexin; oral
2.6
7.3
176
1387
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.9
7.3
29
82
WZA90
NOMESCO Finland
Other doctors statement
2.6
7.2
62
294
L04AB06
ATC
golimumab; parenteral
31.2
7.2
9
*
ZZH40
NOMESCO Finland
Substitute of bone
31.2
7.2
9
*
NB2AT
NOMESCO Finland
Intra artrial injection of shoulder with ultrasound guidance
20.9
7.2
10
5
J01DA01
ATC
[U] cefalexin; systemic
2.2
7.2
140
986
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
9.3
7.2
14
16
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
7.4
7.1
16
23
9271
FHL
Hallux surgery
6.7
7.1
17
27
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.8
7.1
49
205
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.4
7.0
71
369
M03BX01
ATC
baclofen; systemic
14.4
7.0
11
8
J01MA02
ATC
ciprofloxacin; systemic
2.2
6.9
93
551
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.9
6.9
45
182
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.4
6.9
24
60
ZZH20
NOMESCO Finland
Graft of patients own bone
41.4
6.8
8
*
NFC40
NOMESCO Finland
Repair of hip prosthesis by bone transplant to acetabulum
41.4
6.8
8
*
NDG71
NOMESCO Finland
Arthrodes of first MP joint
41.4
6.8
8
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
6.7
42
166
NG1DA
NOMESCO Finland
X-ray of knees
8.2
6.7
14
18
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
12.8
6.7
11
9
NB1AD
NOMESCO Finland
Shoulder CT examination
9.1
6.7
13
15
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
10.5
6.6
12
12
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
10.5
6.6
12
12
R13
ICD-10 Finland
Dysphagia
4.7
6.6
21
48
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.2
6.5
24
63
R50.9
ICD-10 Finland
Fever, unspecified
3.0
6.5
38
145
M01AE02
ATC
naproxen; oral, rectal
2.1
6.5
123
840
A02BC05
ATC
esomeprazole; systemic
2.2
6.5
90
537
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
71.9
6.5
7
*
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
71.9
6.5
7
*
M17.4
ICD-10 Finland
Other secondary gonarthrosis, bilateral
71.9
6.5
7
*
L04AD01
ATC
ciclosporin; systemic
11.5
6.4
11
10
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
11.5
6.4
11
10
A06AD11
ATC
lactulose; oral
3.0
6.4
37
140
H04.10
ICD-10 Finland
Dry eye syndrome
3.2
6.3
33
116
M05BB03
ATC
alendronic acid and colecalciferol; oral
7.4
6.3
14
20
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.7
6.3
46
200
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
18.7
6.3
9
5
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
18.7
6.3
9
5
KFD20
NOMESCO Finland
Excision of hydrocele of testis
18.7
6.3
9
5
M01AX17
ATC
nimesulide; oral
2.4
6.3
63
323
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
+∞
6.3
6
*
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
+∞
6.3
6
*
H05AA02
ATC
teriparatide; parenteral
27.6
6.3
8
*
ZXC95
NOMESCO Finland
Use of surgical navigator
27.6
6.3
8
*
L01AA01
ATC
cyclophosphamide; systemic
27.6
6.3
8
*
318
Kela drug reimbursment
Teriparatide
27.6
6.3
8
*
J01MA14
ATC
moxifloxacin; systemic
3.6
6.2
27
83
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.3
6.2
71
387
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
43
36
14.35
44.02
2.1
1.5
15388.2
22778.9
e6/l
0.17
32
25
40
42
11.24
35.16
1.9
1.3
—
—
—
0
0
149
794
3.33
18.17
3.1
2.2
79.3
78.2
nmol/l
0.17
137
705
178
1086
3.50
16.72
18.1
9.3
4.4
4.0
e9/l
1.70
173
954
23
31
8.10
16.40
1.8
1.5
—
—
—
0
0
30
57
5.88
15.58
2.0
1.5
2.9
0.0
iu/ml
—
7
10
207
1438
4.28
14.85
12.9
3.7
14.9
12.2
mm/h
1.61
201
1297
97
445
2.99
14.62
2.6
2.1
3.7
3.2
mg/l
1.37
86
379
17
21
8.64
12.92
1.1
1.0
—
—
—
0
0
201
1491
3.19
10.42
13.8
7.2
72.8
78.5
u/l
1.65
194
1385
138
859
2.44
10.25
5.9
5.5
1.2
1.2
mmol/l
0.32
126
787
11
10
11.48
10.23
1.5
1.6
—
—
—
0
0
144
914
2.45
10.23
7.2
3.4
0.0
0.0
estimate
0.00
38
184
147
943
2.45
10.18
7.3
6.7
1.2
1.2
mmol/l
0.06
120
802
144
929
2.38
9.65
7.6
3.5
0.0
0.0
estimate
0.50
41
176
143
924
2.36
9.49
9.7
4.8
0.0
0.0
estimate
0.00
44
180
137
877
2.32
9.18
5.3
3.6
—
—
—
0
0
62
282
2.62
8.92
2.0
1.9
—
—
—
0
0
158
1098
2.30
8.40
4.9
4.3
6.3
6.7
mmol/l
2.27
153
1015
16
33
5.12
7.52
4.7
2.5
5.2
4.2
e9/l
1.27
16
33
16
33
5.12
7.52
4.7
2.6
66.3
58.7
%
1.51
16
33
112
702
2.12
7.43
4.4
3.5
3628.7
46.6
ng/l
0.49
87
502
66
344
2.27
6.88
1.7
1.7
1057.0
1134.1
nmol/l
0.28
50
248
45
198
2.57
6.82
3.6
7.1
1.4
1.5
mmol/l
0.03
36
166
33
126
2.88
6.55
1.8
1.5
—
—
—
0
0
117
778
1.99
6.31
3.3
2.6
103.1
122.3
ug/l
0.73
112
713
84
499
2.05
6.20
8.5
3.5
0.0
0.0
estimate
0.50
43
185
43
200
2.40
5.76
3.2
2.9
—
—
—
0
0
76
449
2.02
5.61
2.9
2.3
—
—
—
0
0
17
47
3.82
5.59
1.7
1.4
—
—
—
0
0
106
720
1.85
5.05
8.4
3.6
—
—
—
0
0
16
47
3.58
4.84
1.3
1.5
—
—
—
0
0
27
111
2.61
4.66
1.8
1.6
—
—
—
0
0
18
59
3.22
4.62
3.3
2.6
—
—
—
0
0
39
192
2.23
4.56
1.9
1.8
—
—
—
0
0
87
574
1.81
4.44
3.0
3.2
1306.7
1153.2
ng/l
0.19
79
489
11
27
4.22
4.21
1.5
2.0
—
—
—
0
0
38
193
2.15
4.11
1.9
1.7
—
—
—
0
0
95
665
1.71
3.84
5.4
2.9
—
—
—
0
0
10
25
4.13
3.73
1.5
2.1
—
—
—
0
0
83
564
1.72
3.72
2.1
2.3
53.0
57.8
u/l
1.04
78
515
53
315
1.88
3.71
1.2
1.2
71.4
37.0
iu/ml
0.90
27
110
51
302
1.88
3.60
1.2
1.2
159.8
16.3
u/ml
0.80
24
118
42
233
1.97
3.59
4.9
6.4
103.9
104.2
mmol/l
0.12
42
225
8
13
6.32
3.53
1.3
1.2
—
—
—
0
0
17
64
2.78
3.48
2.1
1.7
—
—
—
0
0
12
37
3.36
3.39
1.6
1.8
—
—
—
0
0
7
10
7.17
3.38
2.0
1.0
—
—
—
0
0
30
150
2.14
3.38
3.8
7.3
1.1
1.3
mmol/l
0.39
30
144
14
48
3.04
3.36
1.8
1.8
—
—
—
0
0
73
497
1.67
3.18
4.3
2.7
0.4
0.5
e6/l
0.26
65
374
14
50
2.91
3.14
1.8
1.8
—
—
—
0
0
104
778
1.60
3.09
2.2
1.9
92.9
97.6
pmol/l
0.39
54
382
128
1007
1.58
3.06
4.6
6.1
9.3
10.9
umol/l
2.26
122
958
24
115
2.21
3.00
3.5
8.4
1.2
1.4
%
0.57
24
115
62
414
1.67
2.88
1.7
1.7
407.7
439.8
pmol/l
0.40
53
324
14
53
2.74
2.85
1.4
1.2
—
—
—
0
0
15
59
2.65
2.84
1.5
2.8
—
—
—
0
0
214
1938
2.00
2.78
32.8
12.4
17.3
23.2
mg/l
3.44
203
1496
66
453
1.63
2.75
1.7
1.4
16.6
21.8
nmol/l
3.46
56
377
17
73
2.43
2.72
2.4
2.0
—
—
—
0
0
17
73
2.43
2.72
1.3
1.7
—
—
—
0
0
17
73
2.43
2.72
1.3
1.7
3.9
3.7
g/l
0.18
12
54
39
232
1.81
2.70
7.5
6.4
—
—
—
0
0
27
143
2.00
2.64
2.2
2.3
7.6
6.9
ug/l
0.10
19
132
22
108
2.14
2.61
3.8
8.9
95.4
94.5
%
0.58
22
108
24
122
2.08
2.61
1.1
1.3
130.7
195.4
iu/ml
0.29
11
52
9
25
3.70
2.60
1.0
1.1
—
—
—
0
0
10
33
3.12
2.55
2.1
1.8
—
—
—
0
0
23
116
2.09
2.55
3.6
8.3
0.6
0.7
%
0.15
23
116
77
559
1.56
2.51
3.0
2.0
148.3
210.2
u/l
0.77
77
525
23
117
2.07
2.50
4.2
3.6
4.3
4.6
pmol/l
0.62
23
103
14
57
2.55
2.50
1.3
1.9
0.0
0.0
g/l
0.00
14
52
12
46
2.69
2.40
1.3
1.2
—
—
—
0
0
12
46
2.69
2.40
1.3
1.9
—
—
—
0
0
20
100
2.09
2.28
1.4
1.2
—
—
—
0
0
12
48
2.58
2.22
1.9
1.9
—
—
—
0
0
6
14
4.37
2.16
1.0
2.2
—
—
—
0
0
6
14
4.37
2.16
1.0
2.2
—
—
—
0
0
6
14
4.37
2.16
1.0
2.2
—
—
—
0
0
8
25
3.27
2.11
1.8
1.8
—
—
—
0
0
64
462
1.53
2.11
3.3
2.7
7162.3
10194.4
umol/l
0.17
57
401
8
26
3.15
2.03
1.0
2.0
—
—
—
0
0
8
26
3.15
2.03
1.0
2.0
—
—
—
0
0
8
26
3.15
2.03
1.0
2.0
—
—
—
0
0
26
150
1.82
2.00
7.2
6.3
7.0
8.9
mmol/l
1.45
26
139
44
295
1.60
1.99
4.0
3.2
0.8
0.8
mmol/l
0.54
44
279
43
289
1.59
1.93
4.0
2.4
1.3
1.4
e6/l
0.11
30
166
6
17
3.59
1.85
1.0
2.1
—
—
—
0
0
6
17
3.59
1.85
1.0
2.1
—
—
—
0
0
6
17
3.59
1.85
1.0
2.1
—
—
—
0
0
6
17
3.59
1.85
1.0
2.1
—
—
—
0
0
8
30
2.72
1.74
1.6
1.8
—
—
—
0
0
55
400
1.49
1.73
1.9
1.6
1.3
1.2
mg/l
0.13
42
308
167
1485
1.41
1.66
4.6
3.9
15.6
14.8
pmol/l
3.18
154
1334
5
14
3.62
1.62
1.8
1.1
—
—
—
0
0
6
20
3.05
1.59
2.5
1.6
—
—
—
0
0
83
662
1.39
1.58
2.4
3.3
2.4
2.4
mmol/l
0.49
70
580
24
147
1.70
1.54
3.1
2.9
78.8
60.1
ml/min/173m2
—
10
61
5
15
3.38
1.53
1.0
1.0
—
—
—
0
0
5
15
3.38
1.53
1.6
1.2
—
—
—
0
0
5
15
3.38
1.53
1.0
1.1
—
—
—
0
0
203
1886
1.51
1.46
21.4
12.1
83.3
79.7
ml/min/173m2
1.73
178
1541
13
66
2.03
1.46
1.7
1.8
—
—
—
0
0
7
28
2.54
1.46
1.7
1.7
—
—
—
0
0
6
23
2.65
1.37
1.0
1.0
—
—
—
0
0
5
17
2.98
1.36
2.2
1.5
—
—
—
0
0
12
61
2.02
1.35
1.3
1.8
36.5
38.8
g/l
0.75
12
53
11
54
2.09
1.35
1.4
1.9
0.0
0.0
g/l
0.00
11
49
6
24
2.54
1.31
1.8
1.6
—
—
—
0
0
6
24
2.54
1.31
1.0
1.0
—
—
—
0
0
12
62
1.98
1.30
1.2
1.2
—
—
—
0
0
12
62
1.98
1.30
1.2
1.2
—
—
—
0
0
39
281
1.46
1.29
4.3
2.6
3.9
3.1
e6/l
0.28
26
160
11
55
2.05
1.29
1.4
1.9
0.0
0.0
g/l
0.00
11
50
12
63
1.95
1.25
2.2
3.7
1.1
1.4
mmol/l
0.75
12
63
20
126
1.64
1.19
2.0
1.9
—
—
—
0
0
8
40
2.03
1.13
1.3
1.3
—
—
—
0
0
5
21
2.41
1.09
2.6
4.1
—
—
—
0
0
9
47
1.95
1.03
1.8
1.3
—
—
—
0
0
22
148
1.54
1.02
5.5
3.5
4.3
4.5
kpa
0.18
22
140
7
36
1.97
0.98
1.0
1.1
—
10.6
—
0
5
24
168
1.48
0.94
5.4
4.0
5.8
5.9
kpa
0.05
24
159
6
28
2.17
0.92
1.3
1.7
—
—
—
0
0
6
28
2.17
0.92
1.3
1.7
—
—
—
0
0
6
28
2.17
0.92
1.3
1.7
—
—
—
0
0
6
28
2.17
0.92
1.3
1.7
—
—
—
0
0
6
28
2.17
0.92
1.3
1.7
—
—
—
0
0
6
29
2.10
0.90
1.3
1.7
—
—
—
0
0
8
42
1.94
0.89
1.6
1.2
—
—
—
0
0
218
2097
1.45
0.85
30.7
15.1
73.9
75.5
umol/l
0.32
218
2097
6
31
1.96
0.85
1.0
1.1
—
—
—
0
0
15
97
1.58
0.83
1.1
1.0
—
—
—
0
0
37
289
1.33
0.80
2.1
1.7
29.5
29.7
s
0.05
37
280
37
293
1.31
0.74
1.6
1.4
—
—
—
0
0
5
25
2.02
0.73
1.0
1.6
—
—
—
0
0
20
143
1.44
0.73
2.1
1.9
—
—
—
0
0
189
1801
1.24
0.64
5.5
4.7
1.8
2.6
mu/l
0.62
174
1614
34
273
1.29
0.62
4.0
4.2
34.8
32.3
%
0.59
23
172
14
97
1.47
0.60
2.9
2.1
13.8
12.3
nmol/l
0.46
14
91
10
64
1.59
0.59
1.6
1.6
—
—
—
0
0
6
35
1.73
0.58
1.3
1.3
—
—
—
0
0
6
35
1.73
0.58
1.3
1.3
—
—
—
0
0
7
45
1.57
0.49
1.0
1.1
—
—
—
0
0
7
47
1.50
0.48
3.4
2.8
25.6
26.2
mmol/l
—
7
40
7
48
1.47
0.47
1.0
1.1
—
11.8
—
0
9
122
1141
1.14
0.44
2.9
2.8
—
—
—
0
0
5
31
1.63
0.43
1.4
1.4
—
—
—
0
0
5
33
1.53
0.41
1.2
1.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
456.7
—
0
12
0
18
0.00
0.40
0.0
1.1
—
43.8
—
0
12
5
35
1.44
0.39
4.4
1.9
—
—
—
0
0
12
90
1.35
0.36
1.2
1.3
—
—
—
0
0
45
406
1.13
0.28
1.4
1.3
0.8
1.0
u/ml
0.33
21
110
33
292
1.15
0.27
1.3
1.4
—
—
—
0
0
49
530
0.91
0.22
1.7
1.6
1.6
1.3
mmol/l
1.49
42
437
0
11
0.00
0.21
0.0
3.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
3.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
23
202
1.15
0.21
1.5
2.1
4.5
9.8
umol/l
2.29
17
173
0
14
0.00
0.20
0.0
2.0
—
13.1
—
0
14
7
59
1.19
0.18
1.1
1.3
—
—
—
0
0
37
349
1.07
0.10
4.3
3.4
249.1
471.3
ng/l
0.39
28
279
192
1899
1.06
0.09
4.0
3.9
1.3
1.3
mmol/l
0.37
178
1718
39
371
1.06
0.09
4.6
4.5
23.5
21.3
%
0.44
26
193
199
2008
0.95
0.08
4.9
4.9
2.7
2.8
mmol/l
0.54
184
1828
182
1838
0.96
0.07
5.8
5.7
38.7
39.6
mmol/mol
0.88
170
1689
196
1966
0.98
0.00
4.6
4.3
4.7
4.7
mmol/l
0.07
182
1804
195
1954
0.99
0.00
4.5
4.3
1.6
1.5
mmol/l
0.66
181
1783
175
1753
0.99
0.00
26.8
13.7
37.3
39.6
%
1.43
101
1266
195
1945
1.01
0.00
4.4
4.5
5.7
5.9
mmol/l
2.81
180
1756
0
8
0.00
0.00
0.0
2.5
—
—
—
0
0
0
8
0.00
0.00
0.0
2.5
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
7
0.00
0.00
0.0
2.6
—
106.0
—
0
7
0
6
0.00
0.00
0.0
1.0
—
106.5
—
0
6
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
131.8
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
0.00
1.8
1.4
—
—
—
0
0
7
71
0.99
0.00
1.6
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
30.3
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint M13_ATLOAXSUBLUX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ATLOAXSUBLUX | 2.573 [2.2, 3.01] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.099 |
During the follow-up period (1.1.1998 — 31.12.2019), 298 out of 797 females with M13_ATLOAXSUBLUX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ATLOAXSUBLUX | 1.478 [1.18, 1.85] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 129 out of 500 males with M13_ATLOAXSUBLUX died.
Mortality risk
Mortality risk for people of age
years, who have M13_ATLOAXSUBLUX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.239% |
| 5 | 1.353% | 1.353% |
| 10 | 3.347% | 3.58% |
| 15 | 6.752% | 6.956% |
| 20 | 11.712% | 11.871% |
Relationships between endpoints
↥Index endpoint: M13_ATLOAXSUBLUX – Atlantoaxial subluxation
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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