Contracture of muscle

M13_MUSCONTRAC

muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M62.4 Cause of death: ICD-10 — M62.4 2 out of 7 registries used, show all original rules.	145
4. Check minimum number of events None	145
5. Include endpoints None	145
6. Filter based on genotype QC (FinnGen only)	145

Control definitions (FinnGen only)

Control exclude: M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M62
Name in latin: Contractura musculi

NAME	M13_MUSCONTRAC
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M624
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M624
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Contracture of muscle based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1175	667	502
Only index persons	1106	642	464
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	46.18	48.13	43.55
Only index persons	46.00	48.18	42.98

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	145	97	48
Unadjusted period prevalence (%)	0.03	0.03	0.02
Median age at first event (years)	55.88	53.15	61.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
130: Matched controls
1298

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M62.4

ICD-10 Finland

Contracture of muscle

+∞

183.8

130

M79.6

ICD-10 Finland

Pain in limb

8.0

25.0

169

M25.5

ICD-10 Finland

Pain in joint

5.2

15.4

173

M76.6

ICD-10 Finland

Achilles tendinitis

13.7

11.8

M01AH05

ATC

etoricoxib; oral

3.6

10.8

519

M72.2

ICD-10 Finland

Plantar fascial fibromatosis

8.0

9.8

Z3226

NOMESCO Finland

Physiotherapist

4.1

8.9

114

M77.4

ICD-10 Finland

Metatarsalgia

10.1

8.9

M03BC01

ATC

orphenadrine (citrate); systemic

3.6

8.7

165

A02BC02

ATC

pantoprazole; systemic

3.2

8.7

574

M79.1

ICD-10 Finland

Myalgia

5.4

8.6

N03AX16

ATC

pregabalin; oral

4.0

8.3

114

N02AJ06

ATC

codeine and paracetamol; systemic

3.1

8.0

268

M75.1

ICD-10 Finland

Rotator cuff syndrome

4.2

7.7

M03BX02

ATC

tizanidine; oral

2.9

7.7

566

M54.4

ICD-10 Finland

Lumbago with sciatica

4.5

7.5

G44.2

ICD-10 Finland

Tension-type headache

4.8

7.2

N02AX02

ATC

tramadol; systemic, rectal

2.9

7.1

272

M54.5

ICD-10 Finland

Low back pain

3.0

7.1

217

M19.0

ICD-10 Finland

Primary arthrosis of other joints

5.7

6.8

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

3.0

6.7

194

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

3.6

6.4

N02BE01

ATC

paracetamol; systemic, rectal

3.5

6.3

115

893

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.7

6.2

263

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.6

6.2

366

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

5.9

6.1

M20.1

ICD-10 Finland

Hallux valgus (acquired)

5.2

6.1

Mortality – FinRegistry

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Association

Association between endpoint M13_MUSCONTRAC and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_MUSCONTRAC	1.421 [0.96, 2.1]	0.078
Birth year	0.995 [0.99, 1.0]	0.284

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 551 females with M13_MUSCONTRAC died.

Males

Parameter	HR [95% CI]	p-value
M13_MUSCONTRAC	1.473 [1.01, 2.14]	0.043
Birth year	0.985 [0.98, 0.99]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 432 males with M13_MUSCONTRAC died.

Mortality risk

Mortality risk for people of age

years, who have M13_MUSCONTRAC.

N-year risk	Females	Males
1	0.125%	0.285%
5	0.741%	1.557%
10	2.007%	3.941%
15	3.94%	7.491%
20	7.177%	13.183%

Relationships between endpoints

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Index endpoint: M13_MUSCONTRAC – Contracture of muscle

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Contracture of muscle

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints