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R13

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Contracture of muscle

DOID EFO Endpoint Browser PheWeb

M13_MUSCONTRAC

muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M62.4
  • Cause of death: ICD-10 — M62.4

2 out of 7 registries used, show all original rules.

154

4. Check minimum number of events

None

154

5. Include endpoints

None

154

6. Filter based on genotype QC (FinnGen only)

151

Control definitions (FinnGen only)

Control exclude
M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M62
Name in latin
Contractura musculi

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1175 667 502
Only index persons 1106 642 464
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 46.18 48.13 43.55
Only index persons 46.00 48.18 42.98

-FinnGen-

Key figures

All Female Male
Number of individuals 151 102 49
Unadjusted period prevalence (%) 0.03 0.04 0.02
Median age at first event (years) 56.00 53.35 61.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
154
Matched controls
1540
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M62.4
ICD-10 Finland
Contracture of muscle
+∞
222.6
154
*
M79.6
ICD-10 Finland
Pain in limb
6.8
31.3
97
310
M25.5
ICD-10 Finland
Pain in joint
4.8
20.4
74
251
L08
ICPC
Shoulder symptom/complaint
4.3
13.4
42
123
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
6.0
13.0
25
48
M76.6
ICD-10 Finland
Achilles tendinitis
12.0
12.2
22
21
M75.1
ICD-10 Finland
Rotator cuff syndrome
4.2
12.2
39
115
Z3226
NOMESCO Finland
Physiotherapist
3.8
11.6
43
141
M19.0
ICD-10 Finland
Primary arthrosis of other joints
5.6
11.1
23
47
TQW40
NOMESCO Finland
Remowal of suture of skin
6.1
10.7
20
37
M01AH05
ATC
etoricoxib; oral
3.3
10.7
108
642
M79.1
ICD-10 Finland
Myalgia
4.0
10.3
34
102
L03
ICPC
Low back symptom/complaint
3.2
10.3
54
220
N03AX16
ATC
[U] pregabalin
3.3
10.1
48
184
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.1
10.0
56
237
R4120
NOMESCO Finland
Occupational therapy
5.6
9.4
19
38
N02AJ06
ATC
codeine and paracetamol; systemic
2.8
9.3
78
408
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.9
8.9
21
48
A02BC02
ATC
pantoprazole; systemic
3.1
8.9
114
740
WX704
NOMESCO Finland
Intubation
5.3
8.9
19
40
M77.4
ICD-10 Finland
Metatarsalgia
8.2
8.8
19
26
R4110
NOMESCO Finland
Physiotherapy
2.9
8.7
57
260
N02AX02
ATC
tramadol; systemic, rectal
2.8
8.7
70
356
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.5
8.7
35
120
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.6
8.6
33
109
WX320
NOMESCO Finland
Spinalanesthesy
3.0
8.6
48
200
M03BC01
ATC
orphenadrine (citrate); systemic
3.0
8.5
49
208
M54.5
ICD-10 Finland
Low back pain
2.8
8.5
60
285
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.7
8.4
77
417
Z2221
NOMESCO Finland
Medical doctor
2.8
8.2
58
275
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
4.8
7.9
19
44
Z71.8
ICD-10 Finland
Other specified counselling
2.7
7.9
65
331
M20.1
ICD-10 Finland
Hallux valgus (acquired)
4.1
7.8
23
63
G44.2
ICD-10 Finland
Tension-type headache
3.4
7.8
31
105
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
26.5
7.7
10
*
M54.4
ICD-10 Finland
Lumbago with sciatica
3.3
7.6
32
112
X59
ICD-10 Finland
Exposure to unspecified factor
3.2
7.4
34
126
WX702
NOMESCO Finland
Supraglottic ventilation device
6.4
7.2
18
31
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
14.7
7.0
11
8
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
6.9
67
364
M03BX02
ATC
tizanidine; oral
2.5
6.7
106
717
M54.9
ICD-10 Finland
Dorsalgia, unspecified
3.7
6.4
22
67
R42
ICD-10 Finland
Dizziness and giddiness
2.7
6.4
40
175
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
6.2
6.3
16
28
N06AX21
ATC
duloxetine; oral
3.6
6.3
22
68
M03BC51
ATC
orphenadrine, combinations; systemic
2.5
6.3
52
261
ZXA05
NOMESCO Finland
Left side
2.7
6.1
39
172

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
93
543
2.80
8.85
5.2
5.3
56.21
55.84
%
0.12
87
518
30
92
3.81
8.75
1.2
1.1
—
—
—
0
0
117
781
3.07
8.45
5.7
3.6
—
2628.15
—
0
13
93
554
2.71
8.33
5.3
5.4
29.11
29.29
%
0.06
87
527
45
186
3.01
8.15
2.6
2.4
4.46
2.51
e6/l
0.42
26
97
96
587
2.69
8.07
5.4
5.9
0.22
0.19
e9/l
0.88
88
520
122
854
3.06
7.68
4.4
3.4
11.00
11.33
mm/h
0.11
114
780
88
525
2.58
7.64
4.4
5.7
—
—
—
0
0
75
415
2.57
7.63
2.2
1.7
107.17
98.42
pmol/l
0.57
37
214
89
536
2.56
7.54
5.3
5.3
3.09
2.92
%
0.33
83
507
89
541
2.53
7.32
5.7
5.6
8.77
8.55
%
0.26
82
512
54
259
2.67
7.31
1.4
1.3
0.90
2.22
u/ml
—
7
68
94
589
2.53
7.20
5.2
5.3
1.88
1.89
e9/l
0.05
88
529
86
518
2.50
7.17
5.6
5.3
0.57
0.70
%
1.45
79
483
92
574
2.50
7.07
5.0
5.3
0.04
0.04
e9/l
0.13
79
500
43
189
2.77
6.85
3.4
3.1
240.56
185.06
ng/l
0.12
32
141
18
45
4.40
6.84
2.6
2.4
—
—
—
0
0
91
572
2.44
6.78
5.0
5.3
0.60
0.56
e9/l
1.00
79
499
48
230
2.58
6.40
1.8
1.6
1.12
1.33
mg/l
0.23
39
180
33
134
2.86
6.04
1.5
1.3
240.00
252.90
titre
—
7
31
102
701
2.35
5.85
7.7
9.7
4.03
4.00
e9/l
0.06
86
609
50
254
2.43
5.83
2.4
2.8
319.42
13824.33
umol/l
2.55
43
221
72
431
2.26
5.73
3.8
3.0
106.58
93.69
e6/l
0.05
48
300
58
317
2.33
5.72
3.0
2.6
—
—
—
0
0
147
1260
4.66
5.61
18.6
11.4
23.74
24.01
mg/l
0.03
119
951
62
356
2.24
5.39
3.1
2.6
14.08
86.57
e6/l
2.21
45
274
35
156
2.61
5.33
1.3
1.2
7.19
15.45
u/ml
0.53
11
64
122
925
2.53
5.33
5.2
3.8
14.15
14.73
pmol/l
1.84
114
833
75
469
2.17
5.24
4.7
4.2
36.40
36.10
g/l
0.19
69
447
47
243
2.34
5.20
1.3
1.4
2.13
2.35
g/l
0.40
22
143
38
180
2.48
5.09
1.4
1.2
9.54
35.24
iu/ml
2.31
13
67
61
357
2.17
4.99
1.9
2.1
56.67
68.60
u/l
0.44
55
334
82
539
2.12
4.95
6.7
6.5
1.23
1.21
mmol/l
2.02
74
467
58
334
2.18
4.93
3.1
2.6
0.23
0.48
e6/l
0.88
43
248
60
353
2.15
4.81
2.9
2.5
—
—
—
0
0
138
1140
3.03
4.55
6.3
4.4
1.84
1.88
mu/l
0.19
130
1033
110
824
2.17
4.53
5.4
3.7
—
—
—
0
0
75
491
2.03
4.44
5.4
5.7
1.23
1.21
mmol/l
1.50
69
451
48
267
2.16
4.38
2.3
1.8
2.54
3.11
mg/l
1.09
41
232
45
245
2.18
4.33
1.7
1.4
18.53
20.46
nmol/l
0.52
40
210
42
229
2.15
4.00
2.2
2.8
528.74
561.47
mosm/kgh2o
0.49
35
199
43
240
2.10
3.84
2.1
2.3
4.01
8.55
e6/l
0.75
35
217
11
24
4.85
3.82
1.4
1.9
—
—
—
0
0
133
1110
2.45
3.72
6.0
5.0
39.25
39.13
mmol/mol
0.05
124
1035
11
26
4.47
3.58
1.2
1.8
—
—
—
0
0
17
64
2.86
3.53
1.3
1.3
—
29.40
—
0
5
74
519
1.82
3.29
2.4
1.9
—
—
—
0
0
12
34
3.74
3.28
1.5
1.1
—
—
—
0
0
18
73
2.66
3.27
1.2
4.3
62.53
66.96
g/l
1.33
13
66
93
701
1.82
3.24
3.9
4.1
6.63
6.58
mmol/l
0.07
88
651
148
1344
3.60
3.23
19.2
13.4
73.97
74.38
umol/l
0.05
148
1344
58
380
1.84
3.19
3.8
3.4
2.36
2.36
mmol/l
0.05
53
343
138
1193
2.51
3.17
4.6
4.0
5.73
5.83
mmol/l
0.59
128
1093
71
498
1.79
3.11
21.5
10.1
1.39
1.15
inr
0.77
14
149
6
8
7.74
3.08
1.5
1.9
—
—
—
0
0
46
286
1.87
2.96
4.2
3.8
—
—
—
0
0
50
320
1.83
2.93
6.3
7.6
—
—
—
0
0
33
184
2.01
2.91
1.6
1.5
870.84
1228.94
nmol/l
1.87
23
136
19
85
2.41
2.84
1.2
1.3
234.00
143.81
iu/ml
—
7
35
47
299
1.82
2.79
3.8
3.2
92.45
94.14
%
0.19
47
293
103
825
1.75
2.68
4.0
3.3
—
—
—
0
0
10
31
3.38
2.57
1.1
1.1
—
—
—
0
0
5
7
7.33
2.56
1.6
2.3
—
—
—
0
0
14
58
2.56
2.45
1.4
4.2
—
—
—
0
0
138
1224
2.23
2.45
4.4
4.0
1.51
1.51
mmol/l
0.01
128
1134
6
12
5.15
2.42
1.3
1.2
—
—
—
0
0
140
1254
2.28
2.33
5.4
4.4
2.83
2.84
mmol/l
0.02
132
1163
138
1230
2.17
2.31
4.5
4.0
4.84
4.75
mmol/l
0.46
130
1147
34
209
1.80
2.23
2.3
2.7
2.44
2.44
mmol/l
0.11
26
190
26
147
1.92
2.20
1.3
1.2
—
—
—
0
0
9
30
3.12
2.18
4.1
2.5
—
—
—
0
0
134
1189
1.98
2.16
3.9
3.6
1.27
1.24
mmol/l
0.21
126
1098
56
400
1.63
2.13
2.4
2.0
—
—
—
0
0
11
43
2.68
2.13
1.1
1.0
—
—
—
0
0
144
1323
2.36
1.92
15.7
10.7
—
—
—
0
0
128
1133
1.77
1.90
23.8
15.1
332.64
332.44
g/l
0.09
128
1128
75
591
1.52
1.80
4.4
4.6
0.00
0.00
estimate
—
9
113
39
265
1.63
1.78
3.1
3.2
—
—
—
0
0
13
61
2.24
1.77
1.7
1.2
—
—
—
0
0
43
300
1.60
1.76
3.3
2.9
57.92
47.95
mg/l
0.11
30
191
17
91
1.98
1.68
5.1
4.7
—
—
—
0
0
24
145
1.78
1.66
1.3
1.2
—
—
—
0
0
6
20
3.08
1.59
1.2
1.5
—
—
—
0
0
25
158
1.70
1.49
3.0
1.9
—
—
—
0
0
10
46
2.26
1.43
6.1
3.7
—
—
—
0
0
12
61
2.05
1.37
6.2
2.7
4.40
4.57
pmol/l
0.30
12
53
37
264
1.53
1.36
1.6
2.0
—
—
—
0
0
20
122
1.73
1.35
1.5
1.4
—
—
—
0
0
72
587
1.43
1.35
2.8
3.3
0.00
0.00
estimate
—
9
121
21
130
1.71
1.35
4.2
6.3
0.93
1.34
mmol/l
0.23
15
107
73
598
1.42
1.33
2.9
3.3
0.00
0.00
estimate
—
7
104
9
43
2.16
1.33
4.9
9.9
—
—
—
0
0
9
43
2.16
1.33
1.1
1.7
1.29
1.52
g/l
—
9
36
9
43
2.16
1.33
1.0
1.1
—
—
—
0
0
45
338
1.47
1.30
3.2
2.8
8.91
7.65
mmol/l
0.87
36
285
8
36
2.29
1.26
1.6
1.8
—
—
—
0
0
5
19
2.68
1.22
1.2
1.2
—
—
—
0
0
5
19
2.68
1.22
1.2
1.2
—
—
—
0
0
6
26
2.36
1.20
1.2
1.1
—
—
—
0
0
7
30
2.40
1.14
1.3
1.3
—
—
—
0
0
15
90
1.74
1.08
2.6
3.2
—
—
—
0
0
7
35
2.05
1.01
1.4
1.3
—
—
—
0
0
20
134
1.57
0.98
1.1
1.3
—
—
—
0
0
59
487
1.34
0.96
2.7
3.1
6.00
5.81
ph
—
7
48
12
70
1.77
0.95
1.8
1.9
—
—
—
0
0
6
27
2.27
0.94
1.7
1.1
—
—
—
0
0
10
55
1.88
0.94
4.8
3.2
23.82
24.26
mmol/l
—
10
55
41
321
1.38
0.93
3.8
3.6
12.51
8.21
mg/mmol
0.18
27
200
10
57
1.81
0.86
7.5
7.8
—
—
—
0
0
8
45
1.82
0.85
1.1
1.4
20.50
20.63
s
—
8
38
51
419
1.32
0.85
3.6
3.5
169.17
34.07
ng/l
0.46
27
291
0
24
0.00
0.80
0.0
3.6
—
3.97
—
0
24
0
24
0.00
0.80
0.0
3.6
—
—
—
0
0
0
24
0.00
0.80
0.0
3.6
—
105.71
—
0
24
0
25
0.00
0.80
0.0
1.7
—
7.42
—
0
19
14
91
1.59
0.78
1.6
1.3
—
—
—
0
0
19
135
1.46
0.73
3.7
1.5
—
—
—
0
0
65
563
1.27
0.71
6.1
8.2
0.00
0.00
e9/l
0.36
48
459
5
95
0.51
0.69
3.8
2.8
—
—
—
0
0
20
146
1.43
0.68
1.5
1.5
—
—
—
0
0
22
164
1.40
0.67
1.7
1.8
29.94
29.58
s
0.14
22
159
19
138
1.43
0.66
1.9
1.8
—
—
—
0
0
5
29
1.75
0.64
1.0
3.0
10.22
8.61
kpa
—
5
29
29
230
1.32
0.61
1.4
1.6
—
—
—
0
0
8
54
1.51
0.58
1.4
1.1
—
—
—
0
0
24
302
0.76
0.57
3.3
3.3
0.00
0.01
estimate
—
9
108
15
108
1.43
0.55
5.9
6.2
—
—
—
0
0
12
84
1.46
0.51
5.8
2.0
40.25
53.73
u/ml
0.20
12
78
28
337
0.79
0.47
2.9
2.9
—
—
—
0
0
7
48
1.48
0.47
2.4
1.8
—
—
—
0
0
17
131
1.33
0.44
1.9
5.3
2.49
27.86
ug/l
—
10
108
11
79
1.42
0.42
1.4
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
33.93
—
0
15
11
80
1.40
0.39
1.2
2.7
66.57
67.69
e9/l
—
6
59
0
19
0.00
0.39
0.0
1.5
—
8.67
—
0
19
0
19
0.00
0.39
0.0
1.5
—
4.91
—
0
19
0
19
0.00
0.39
0.0
1.5
—
2.67
—
0
10
13
98
1.36
0.39
1.3
1.4
—
—
—
0
0
9
68
1.34
0.38
2.0
2.2
—
—
—
0
0
9
71
1.28
0.37
2.1
4.2
—
—
—
0
0
12
154
0.76
0.34
1.2
1.4
—
—
—
0
0
13
162
0.78
0.30
1.1
1.3
—
—
—
0
0
8
63
1.28
0.28
4.5
4.7
25.50
25.16
mmol/l
—
8
63
6
84
0.70
0.24
4.0
4.5
—
0.79
—
0
31
7
95
0.72
0.23
4.6
4.3
—
1.18
—
0
39
10
79
1.28
0.23
4.8
7.2
93.16
93.66
%
—
10
79
0
11
0.00
0.21
0.0
4.5
—
2.02
—
0
6
0
10
0.00
0.21
0.0
1.2
—
159.54
—
0
10
0
10
0.00
0.21
0.0
2.8
—
—
—
0
0
0
10
0.00
0.21
0.0
7.2
—
—
—
0
0
45
486
0.90
0.21
2.5
2.7
—
—
—
0
0
0
12
0.00
0.21
0.0
2.7
—
—
—
0
0
0
12
0.00
0.21
0.0
2.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
2.3
—
91.07
—
0
14
15
129
1.18
0.17
1.1
1.5
—
—
—
0
0
5
66
0.75
0.17
3.4
3.8
—
—
—
0
0
14
120
1.18
0.17
3.9
3.2
—
—
—
0
0
14
121
1.17
0.15
1.4
1.5
—
—
—
0
0
7
86
0.81
0.15
4.6
4.4
—
0.17
—
0
30
41
388
1.08
0.11
1.4
1.5
—
—
—
0
0
18
163
1.12
0.11
1.2
1.7
—
—
—
0
0
5
43
1.17
0.10
1.2
1.4
—
—
—
0
0
5
43
1.17
0.10
1.2
1.4
—
—
—
0
0
5
44
1.14
0.10
1.2
1.6
—
—
—
0
0
10
88
1.15
0.08
1.5
1.6
—
—
—
0
0
7
82
0.85
0.07
4.6
4.5
—
0.00
—
0
28
32
319
1.00
0.00
2.9
3.8
—
—
—
0
0
0
8
0.00
0.00
0.0
8.8
—
0.63
—
0
8
0
8
0.00
0.00
0.0
2.9
—
1721.88
—
0
8
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
2.8
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
2.2
4.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.8
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint M13_MUSCONTRAC and mortality.

Females

Parameter HR [95% CI] p-value
M13_MUSCONTRAC 1.421 [0.96, 2.1] 0.078
Birth year 0.995 [0.99, 1.0] 0.284

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 551 females with M13_MUSCONTRAC died.

Males

Parameter HR [95% CI] p-value
M13_MUSCONTRAC 1.473 [1.01, 2.14] 0.043
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 432 males with M13_MUSCONTRAC died.

Mortality risk

Mortality risk for people of age

years, who have M13_MUSCONTRAC.

N-year risk Females Males
1 0.125% 0.285%
5 0.741% 1.557%
10 2.007% 3.941%
15 3.94% 7.491%
20 7.177% 13.183%

Relationships between endpoints

↥

Index endpoint: M13_MUSCONTRAC – Contracture of muscle

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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