Contracture of muscle

M13_MUSCONTRAC

muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M62.4 Cause of death: ICD-10 — M62.4 2 out of 7 registries used, show all original rules.	145
4. Check minimum number of events None	145
5. Include endpoints None	145
6. Filter based on genotype QC (FinnGen only)	145

Control definitions (FinnGen only)

Control exclude: M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M62
Name in latin: Contractura musculi

NAME	M13_MUSCONTRAC
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M624
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M624
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Contracture of muscle based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1175	667	502
Only index persons	1106	642	464
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	46.18	48.13	43.55
Only index persons	46.00	48.18	42.98

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	145	97	48
Unadjusted period prevalence (%)	0.03	0.03	0.02
Median age at first event (years)	55.88	53.15	61.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
130: Matched controls
1298

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M62.4

ICD-10 Finland

Contracture of muscle

+∞

183.8

130

M79.6

ICD-10 Finland

Pain in limb

8.0

25.0

169

M25.5

ICD-10 Finland

Pain in joint

5.2

15.4

173

M76.6

ICD-10 Finland

Achilles tendinitis

13.7

11.8

M01AH05

ATC

etoricoxib; oral

3.6

10.8

519

M72.2

ICD-10 Finland

Plantar fascial fibromatosis

8.0

9.8

M77.4

ICD-10 Finland

Metatarsalgia

10.1

8.9

M03BC01

ATC

orphenadrine (citrate); systemic

3.6

8.7

165

A02BC02

ATC

pantoprazole; systemic

3.2

8.7

574

M79.1

ICD-10 Finland

Myalgia

5.4

8.6

N03AX16

ATC

pregabalin; oral

4.0

8.3

114

N02AJ06

ATC

codeine and paracetamol; systemic

3.1

8.0

268

M75.1

ICD-10 Finland

Rotator cuff syndrome

4.2

7.7

M03BX02

ATC

tizanidine; oral

2.9

7.7

566

M54.4

ICD-10 Finland

Lumbago with sciatica

4.5

7.5

G44.2

ICD-10 Finland

Tension-type headache

4.8

7.2

N02AX02

ATC

tramadol; systemic, rectal

2.9

7.1

272

M54.5

ICD-10 Finland

Low back pain

3.0

7.1

217

M19.0

ICD-10 Finland

Primary arthrosis of other joints

5.7

6.8

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

3.0

6.7

194

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

3.6

6.4

N02BE01

ATC

paracetamol; systemic, rectal

3.5

6.3

115

893

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.7

6.2

263

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.6

6.2

366

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

5.9

6.1

M20.1

ICD-10 Finland

Hallux valgus (acquired)

5.2

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(36660697) Celiac disease serology panel - Serum

3.73

8.20

1.2

1.1

—

(3018010) Neutrophils/100 leukocytes in Blood

507

2.71

7.90

5.3

5.4

56.06

56.24

0.05

485

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

171

3.05

7.84

2.6

2.3

4.67

2.38

e6/l

0.46

(3031040) Bacteria [#/volume] in Urine by Automated count

110

743

2.99

7.62

5.7

3.5

—

2628.15

—

(3002030) Lymphocytes/100 leukocytes in Blood

517

2.63

7.45

5.3

5.4

28.84

28.98

0.04

492

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

4.64

7.25

2.6

2.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

385

2.58

7.24

3.4

2.6

—

(3013115) Eosinophils [#/volume] in Blood

549

2.61

7.23

5.4

5.9

0.22

0.19

e9/l

0.97

489

(42870588) Differential panel, method unspecified - Blood

341

2.57

7.03

4.2

4.6

—

(3006504) Eosinophils/100 leukocytes in Blood

501

2.47

6.59

5.4

5.3

3.19

2.89

0.62

471

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

180

2.78

6.57

3.5

3.1

254.70

485.20

ng/l

0.27

134

(3019198) Lymphocytes [#/volume] in Blood

548

2.47

6.51

5.3

1.88

1.89

e9/l

0.02

493

(3019069) Monocytes/100 leukocytes in Blood

506

2.43

6.38

5.8

5.6

8.86

8.46

0.52

482

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

445

2.42

6.38

2.2

2.1

78.94

73.85

nmol/l

0.84

401

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

254

2.55

6.34

1.4

1.2

1.02

2.19

u/ml

—

(3013707) Erythrocyte sedimentation rate by Westergren method

113

812

2.77

6.27

4.3

3.4

10.79

11.20

mm/h

0.13

106

743

(3006315) Basophils [#/volume] in Blood

536

2.42

6.26

5.0

5.3

0.04

e9/l

0.29

468

(3022096) Basophils/100 leukocytes in Blood

486

2.37

6.11

5.7

5.3

0.57

0.69

1.25

456

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

393

2.38

6.06

2.3

1.7

107.45

98.71

pmol/l

0.53

203

(3037522) Nuclear Ab [Titer] in Serum

128

2.92

6.05

1.5

1.3

240.00

263.23

titre

—

(3018095) Leukocytes [#/volume] in Urine

402

2.37

6.03

3.7

3.0

108.83

87.47

e6/l

0.08

276

(3001604) Monocytes [#/volume] in Blood

534

2.36

5.98

5.0

5.3

0.61

0.56

e9/l

1.30

469

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

189

2.63

5.92

2.5

2.2

1.37

1.15

e6/l

0.16

106

(36304419) Bacteria [Presence] in Urine

292

2.42

5.90

3.0

2.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

3.58

5.69

1.2

1.0

—

(3002582) Erythrocytes [#/volume] in Urine

331

2.32

5.52

3.0

2.6

13.65

92.35

e6/l

2.22

253

(3049717) Cytology report of Urine Cyto stain

5.09

5.10

1.4

2.4

—

(3030467) Casts [#/volume] in Urine by Automated count

308

2.27

5.10

3.0

2.6

0.24

0.46

e6/l

0.68

226

(3024561) Albumin [Mass/volume] in Serum or Plasma

443

2.18

5.03

4.6

4.1

36.56

36.06

g/l

0.38

422

(3013650) Neutrophils [#/volume] in Blood by Automated count

656

2.23

5.00

7.9

9.4

4.06

4.05

e9/l

0.02

575

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

226

2.36

4.97

1.7

1.5

1.17

1.32

mg/l

0.15

175

(3026008) Bacteria identified in Urine by Culture

327

2.22

4.96

2.7

2.6

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

138

1189

4.33

4.94

17.8

11.4

23.61

24.06

mg/l

0.05

111

899

(3026493) Urate [Moles/volume] in Serum or Plasma

251

2.29

4.84

2.3

2.7

315.85

14201.40

umol/l

2.55

215

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

341

2.17

4.71

2.0

2.1

56.83

55.63

u/l

0.12

317

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

235

2.25

4.49

2.3

1.8

2.61

2.97

mg/l

0.58

204

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

114

882

2.37

4.44

5.0

3.8

14.22

14.72

pmol/l

1.33

106

796

(3037467) Urinalysis macro (dipstick) panel - Urine

104

776

2.20

4.41

5.3

3.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

237

2.23

4.39

1.3

1.4

2.20

2.25

g/l

0.06

138

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

171

2.38

4.38

1.5

1.2

8.36

28.72

iu/ml

1.76

(3026782) Osmolality of Urine

208

2.27

4.34

2.2

2.7

538.88

582.38

mosm/kgh2o

0.60

182

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

151

2.44

4.31

1.4

1.2

1.21

16.46

u/ml

—

(3000850) Epithelial cells [#/volume] in Urine

220

2.20

4.11

2.1

2.4

4.27

9.15

e6/l

0.72

197

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

105

804

2.11

3.92

3.0

2.7

35.20

43.83

u/l

1.25

761

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

129

1081

2.75

3.78

6.1

4.4

1.86

1.88

mu/l

0.10

121

985

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

506

1.94

3.77

6.8

6.3

1.23

1.22

mmol/l

1.69

439

(3025130) Human papilloma virus identified in Specimen

4.22

3.76

1.2

1.8

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

454

1.94

3.70

5.3

5.7

1.23

1.22

mmol/l

1.38

416

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.52

3.47

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.49

3.40

1.8

1.7

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

348

1.88

3.17

4.0

3.4

2.36

mmol/l

0.02

316

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

157

2.15

3.15

2.5

2.4

—

(40768804) Tissue Pathology biopsy report

491

1.82

3.13

2.4

2.0

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

2.73

3.08

1.2

1.3

—

29.40

—

(3033658) Prothrombin time (PT) actual/Normal

276

1.91

3.06

3.8

3.2

93.56

94.61

0.11

271

(40758558) Short blood count panel - Blood

293

1.89

3.04

6.5

7.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

125

1064

2.27

2.99

5.9

5.0

39.32

39.26

mmol/mol

0.03

116

994

(3013826) Glucose [Moles/volume] in Serum or Plasma

658

1.81

2.98

3.5

4.2

6.63

6.64

mmol/l

0.01

613

(3020630) Protein [Mass/volume] in Serum or Plasma

2.58

2.93

1.2

4.3

62.84

67.04

g/l

1.12

(3019309) Folate [Moles/volume] in Red Blood Cells

170

2.05

2.88

1.6

1.5

861.38

1215.51

nmol/l

1.73

127

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

151

2.06

2.71

1.8

—

(42529406) Shigella sp [Presence] in Stool by Culture

3.28

2.70

1.5

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

3.28

2.70

1.5

1.1

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

139

1275

3.18

2.63

18.8

13.3

74.75

73.88

umol/l

0.10

139

1275

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.66

2.62

1.4

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

273

1.82

2.58

2.6

1.9

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

3.18

2.58

1.5

1.1

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

130

1142

2.34

2.58

4.6

4.0

5.76

5.84

mmol/l

0.43

121

1053

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

185

1.94

2.56

2.3

2.8

2.45

2.44

mmol/l

0.16

170

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

128

1121

2.21

2.50

13.9

10.7

85.73

83.11

ml/min/173m2

0.64

112

912

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.08

2.46

1.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

3.48

2.44

1.1

—

(3044640) Blood type and Crossmatch panel - Blood

366

1.71

2.36

2.4

2.0

—

(3044889) 12 lead EKG panel

776

1.70

2.34

3.9

3.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.69

2.33

2.0

1.7

—

(3023420) DNA double strand Ab [Units/volume] in Serum

5.71

2.23

1.6

1.9

—

(3032080) INR in Blood by Coagulation assay

417

1.65

2.19

14.4

6.4

1.43

1.15

inr

0.74

128

(3008898) HLA-B27 [Presence]

2.69

2.15

1.1

1.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.83

2.15

1.1

1.8

—

(3023368) Bacteria identified in Blood by Culture

270

1.72

2.14

4.3

3.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.45

2.11

1.4

4.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

142

1.92

2.10

2.1

2.3

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.62

2.08

1.1

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.62

2.08

1.1

1.0

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

2.75

2.05

1.8

1.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

794

1.62

1.98

3.7

3.3

—

(3002256) Pathology report gross observation

139

1.87

1.90

1.3

1.2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

130

1173

2.05

1.89

4.3

4.0

1.51

1.52

mmol/l

0.07

120

1090

(3052851) Hemolysis interference index of Serum or Plasma

2.96

1.89

3.5

2.7

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

2.12

1.88

1.1

1.3

315.40

145.01

iu/ml

—

(3022313) Gas panel - Capillary blood

2.61

1.88

6.1

3.8

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

132

1200

2.12

1.84

5.3

4.4

2.84

2.83

mmol/l

0.03

124

1116

(3009542) Hematocrit [Volume Fraction] of Blood

126

1130

1.88

1.80

20.1

12.3

39.85

40.21

0.22

105

876

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

130

1179

1.99

1.77

4.4

4.0

4.85

4.75

mmol/l

0.50

122

1103

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.25

1.66

1.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.06

1.66

2.1

2.0

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

126

1137

1.83

1.66

3.9

3.6

1.27

1.25

mmol/l

0.16

118

1055

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

544

1.51

1.65

3.6

—

(40768797) Stomach Pathology biopsy report

139

1.78

1.60

1.3

1.2

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

2.51

1.56

1.1

1.0

—

14.25

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

249

1.59

1.53

3.1

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.67

1.53

1.6

1.3

—

(40768443) Skin Pathology biopsy report

2.46

1.48

1.0

1.1

—

(3025941) Bacteria identified in Stool by Culture

2.13

1.48

1.6

1.3

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

3.20

1.45

1.2

1.6

—

(40761511) CBC panel - Blood by Automated count

135

1258

2.06

1.40

15.2

10.6

—

(3021601) Nitrite [Presence] in Urine by Test strip

559

1.45

1.38

4.5

4.6

0.00

estimate

—

107

(4034850)

2.16

1.33

4.9

9.9

—

(3022145) Colonoscopy Study observation

115

1.75

1.33

1.5

1.3

—

(3003338) MCHC [Mass/volume]

119

1076

1.59

1.32

23.0

14.8

332.79

332.49

g/l

0.13

119

1071

(3012516) Albumin [Mass/volume] in Urine

287

1.49

1.26

3.6

3.0

52.61

54.73

mg/l

0.02

183

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.92

1.17

2.2

1.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

238

1.50

1.17

1.6

2.0

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

2.06

1.14

1.1

1.6

1.38

1.50

g/l

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

259

1.46

1.09

2.6

3.3

1111.65

1079.86

ng/l

0.02

217

(3009508) Creatinine [Moles/volume] in Urine

322

1.43

1.09

3.3

2.8

8.95

7.73

mmol/l

0.77

273

(3019225) pH of Specimen

1.74

1.09

5.6

4.9

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

114

1.66

1.09

1.9

1.7

—

(3035350) Ketones [Presence] in Urine by Test strip

558

1.37

1.08

2.8

3.3

0.00

estimate

—

108

(3003396) Base excess in Arterial blood by calculation

123

1.63

1.06

3.4

6.7

0.25

1.24

mmol/l

0.78

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.21

0.99

1.8

1.1

—

(40761535) Cells panel - Urine sediment

1.72

0.98

2.8

3.3

—

(3009261) Glucose [Presence] in Urine by Test strip

567

1.34

0.94

3.0

3.3

0.00

estimate

—

101

(3021589) Normoblasts [#/volume] in Blood

519

1.34

0.94

6.0

8.2

0.00

e9/l

0.36

424

(3014576) Chloride [Moles/volume] in Serum or Plasma

137

1.53

0.90

5.0

6.1

104.00

104.59

mmol/l

0.29

132

(3023511) Choriogonadotropin [Units/volume] in Urine

2.04

0.88

1.2

1.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

244

1.40

0.85

1.3

1.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.97

0.85

1.3

1.0

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.78

0.84

1.1

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.91

0.82

1.2

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

246

1.39

0.82

2.7

5.0

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.72

0.81

1.4

1.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

404

1.32

0.80

3.6

3.5

169.17

35.62

ng/l

0.46

277

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.80

0.0

3.5

—

105.54

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.80

0.0

3.5

—

4.01

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.80

0.0

3.5

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.80

0.0

1.6

—

(3042936) Bacteria identified in Isolate by Culture

150

1.47

0.79

3.0

1.9

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

203

1.41

0.78

5.2

4.1

22.82

20.85

0.34

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.88

0.75

1.6

1.8

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.65

0.74

5.7

8.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.79

0.72

1.3

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.79

0.72

1.3

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.79

0.72

1.3

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.79

0.72

1.3

1.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

307

1.32

0.71

4.1

3.8

11.69

9.14

mg/mmol

0.10

194

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.96

0.71

1.2

1.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

127

0.61

0.67

2.0

7.0

—

(3000991) Gas panel - Venous blood

1.52

0.67

5.9

6.8

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.66

0.67

5.6

2.5

4.27

4.59

pmol/l

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.62

0.66

1.4

1.6

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

1.57

0.65

5.8

1.9

40.25

54.82

u/ml

0.21

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.75

0.64

1.6

1.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.75

0.64

1.8

1.5

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

132

1.42

0.60

3.4

4.2

29.75

32.81

0.49

(3010421) pH of Blood

0.00

0.59

0.0

1.6

—

7.43

—

(1002224) Polysomnography panel

1.51

0.58

1.4

1.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

324

0.76

0.58

2.9

3.0

—

(40761536) Microorganisms panel - Urine sediment

0.55

0.58

3.8

2.7

—

(3029937) Albumin [Presence] in Urine by Test strip

290

0.75

0.56

3.4

3.3

0.00

0.01

estimate

—

102

(3003327) Ova and parasites identified in Stool by Light microscopy

1.56

0.53

2.3

1.4

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

128

1.37

0.50

1.9

5.3

2.49

28.79

ug/l

—

104

(3036489) Thrombin time

1.58

0.49

1.1

1.5

20.71

20.56

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.51

0.48

1.6

1.9

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

158

1.31

0.45

1.7

1.8

29.91

29.46

0.17

153

(3000494) Fungus identified in Specimen by Culture

131

1.34

0.44

1.1

1.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.63

0.43

1.4

1.3

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.41

0.0

1.1

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.41

0.0

1.1

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.8

—

(3012501) Base excess in Blood by calculation

0.00

0.41

0.0

1.4

—

2.97

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.41

0.0

1.4

—

8.71

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.41

0.0

1.4

—

5.02

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.44

0.40

4.8

7.9

93.16

93.30

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.40

0.0

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

134

1.30

0.39

1.6

—

(3019060) Gas panel - Arterial blood

1.30

0.37

2.1

4.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

127

1.29

0.35

1.9

1.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

439

0.85

0.34

3.1

3.3

—

(3045414) Leukocytes [Presence] in Urine

1.35

0.34

2.7

1.9

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.35

0.34

1.5

1.7

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.32

0.33

1.3

1.7

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.32

0.33

1.3

1.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.29

0.32

1.7

1.9

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.34

0.31

4.1

5.5

25.29

25.28

mmol/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

141

0.76

0.31

1.3

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

205

1.20

0.30

1.4

1.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

132

1.24

0.27

3.6

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.30

0.27

1.4

1.5

—

(1761868) Lipid panel - Serum or Plasma

460

0.88

0.25

2.6

2.7

—

(3002179) Metamyelocytes/100 leukocytes in Blood

0.73

0.25

4.0

4.7

—

0.59

—

(3017181) Myelocytes/100 leukocytes in Blood

0.75

0.23

4.6

—

0.95

—

(4010399)

1.26

0.21

1.8

1.4

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

1.2

—

91.32

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

2.7

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

2.8

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.21

0.0

2.3

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.27

0.21

1.2

1.3

—

(3012544) pH of Venous blood

108

1.22

0.21

3.8

3.2

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.8

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.20

0.0

1.8

—

33.93

—

(21494755) Public health laboratory ask at order entry panel

154

0.83

0.20

1.1

1.3

—

(3003694) ABO and Rh group [Type] in Blood

350

1.12

0.19

1.4

1.5

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.19

0.17

1.3

1.6

—

(4035726)

111

1.19

0.16

1.5

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.22

0.16

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

106

0.84

0.13

2.2

3.0

—

(3000492) Spirometry study

116

1.13

0.09

1.2

1.5

—

(3020891) Body temperature

1.04

0.09

2.2

3.8

—

(3022621) pH of Urine by Test strip

1.12

0.08

2.3

2.5

—

(3025159) Blasts/100 leukocytes in Blood

0.86

0.07

4.6

4.7

—

0.00

—

(3021440) Promyelocytes/100 leukocytes in Blood

0.82

0.07

4.6

4.7

—

0.19

—

(3013512) EKG study

304

0.94

0.06

3.1

3.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

239

0.96

0.03

2.7

1.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

139

1.01

0.00

1.2

1.8

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

2.2

—

1097.33

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.7

—

69.45

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.2

—

124.83

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

117.00

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(3029536) Hepatitis C virus RNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.7

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

3.7

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.4

—

(44806420)

0.00

0.0

2.3

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.1

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

8.3

—

0.64

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.0

—

(4024509)

0.00

0.0

1.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.1

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.3

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

3.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.0

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.5

—

(3000012) Reticulocyte production index

0.00

0.0

1.2

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.4

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.2

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1472.60

—

(4146454)

0.00

0.0

2.9

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3004451) EKG impression Narrative

0.00

0.0

1.4

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.1

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.0

1.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

7.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_MUSCONTRAC and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_MUSCONTRAC	1.421 [0.96, 2.1]	0.078
Birth year	0.995 [0.99, 1.0]	0.284

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 551 females with M13_MUSCONTRAC died.

Males

Parameter	HR [95% CI]	p-value
M13_MUSCONTRAC	1.473 [1.01, 2.14]	0.043
Birth year	0.985 [0.98, 0.99]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 432 males with M13_MUSCONTRAC died.

Mortality risk

Mortality risk for people of age

years, who have M13_MUSCONTRAC.

N-year risk	Females	Males
1	0.125%	0.285%
5	0.741%	1.557%
10	2.007%	3.941%
15	3.94%	7.491%
20	7.177%	13.183%

Relationships between endpoints

↥

Index endpoint: M13_MUSCONTRAC – Contracture of muscle

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Contracture of muscle

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints