No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
102 |
4. Check minimum number of eventsNone |
102 |
5. Include endpoints |
256 |
6. Filter based on genotype QC (FinnGen only) |
248 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF3
Increased muscle tone
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2783 | 1485 | 1289 |
| Only index persons | 2421 | 1322 | 1099 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 25.36 | 29.73 | 20.19 |
| Only index persons | 27.32 | 31.23 | 22.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 248 | 159 | 89 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | 51.41 | 47.97 | 57.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 256
- Matched controls
- 2560
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M62.4
ICD-10 Finland
Contracture of muscle
1875.0
180.4
154
*
R29.3
ICD-10 Finland
Abnormal posture
+∞
65.5
60
*
R29.0
ICD-10 Finland
Tetany
+∞
36.3
34
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.3
13.9
39
102
M79.6
ICD-10 Finland
Pain in limb
2.4
10.9
129
756
R4120
NOMESCO Finland
Occupational therapy
3.8
9.4
30
86
Z3226
NOMESCO Finland
Physiotherapist
2.6
9.1
61
272
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.9
9.0
28
79
R4110
NOMESCO Finland
Physiotherapy
2.4
8.8
83
433
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
4.2
8.6
24
62
N03AX16
ATC
[U] pregabalin
2.4
8.4
69
337
78850
ICD-8 Finland
Other general symptoms, Tetany
+∞
8.4
8
*
Z2221
NOMESCO Finland
Medical doctor
2.3
8.3
82
435
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
3.4
8.1
30
95
WX702
NOMESCO Finland
Supraglottic ventilation device
3.8
8.1
25
70
M20.1
ICD-10 Finland
Hallux valgus (acquired)
3.3
7.5
30
100
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.9
7.2
22
61
A02BC02
ATC
pantoprazole; systemic
2.1
7.2
171
1252
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
7.2
49
219
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
7.1
107
663
M76.6
ICD-10 Finland
Achilles tendinitis
3.8
7.0
22
62
U07
ICPC
Urine symptom/complaint other
3.3
7.0
27
88
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.9
6.9
34
128
WX704
NOMESCO Finland
Intubation
3.2
6.8
28
95
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.5
6.6
46
207
R42
ICD-10 Finland
Dizziness and giddiness
2.3
6.4
59
300
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
6.4
82
476
R2110
NOMESCO Finland
Giving the first information
3.6
6.3
21
62
M25.5
ICD-10 Finland
Pain in joint
2.0
6.2
91
553
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.9
6.2
30
112
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.2
6.0
25
85
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
66
314
2.48
8.54
2.4
3.1
3.72
2.45
e6/l
0.38
39
164
113
699
2.10
7.66
3.1
3.2
—
—
—
0
0
63
338
2.15
5.99
2.5
3.0
1.31
0.87
e6/l
0.54
37
186
62
337
2.11
5.67
3.8
3.5
184.26
173.27
ng/l
0.03
43
241
88
550
1.91
5.41
3.1
3.2
0.20
0.33
e6/l
0.70
69
406
115
794
1.81
5.10
5.3
5.0
36.67
36.08
g/l
0.56
107
752
141
1048
1.77
4.77
4.3
6.6
9.84
11.27
umol/l
1.52
136
998
31
135
2.47
4.75
1.1
1.0
—
—
—
0
0
128
931
1.75
4.62
9.0
7.8
1.23
1.22
mmol/l
0.75
114
814
106
733
1.76
4.55
2.2
1.9
103.44
96.89
pmol/l
0.55
53
382
117
857
1.67
3.93
7.6
7.5
1.23
1.22
mmol/l
0.71
110
797
156
1236
1.67
3.83
7.8
9.4
4.18
4.01
e9/l
0.49
138
1080
187
1556
1.75
3.81
6.7
7.3
81.60
79.85
u/l
0.13
180
1463
183
1523
1.71
3.63
4.7
4.0
12.16
11.20
mm/h
0.38
172
1389
79
535
1.69
3.50
1.4
1.3
0.88
1.29
u/ml
—
9
132
191
1615
1.72
3.49
4.8
3.9
14.24
14.64
pmol/l
1.51
181
1464
112
836
1.60
3.35
24.6
11.5
1.26
1.17
inr
0.42
25
238
37
201
1.98
3.34
2.1
1.9
—
—
—
0
0
113
847
1.60
3.31
2.5
2.4
75.97
74.47
nmol/l
0.25
102
755
88
624
1.63
3.23
2.2
2.4
56.04
64.13
u/l
0.52
80
579
147
1179
1.58
3.18
5.1
5.3
6.49
6.49
mmol/l
0.00
139
1086
68
455
1.67
3.11
1.8
2.0
1.56
1.35
mg/l
0.15
57
357
36
199
1.94
3.09
2.0
1.8
—
—
—
0
0
16
63
2.64
3.02
1.4
1.2
—
—
—
0
0
16
63
2.64
3.02
1.4
1.2
—
—
—
0
0
90
652
1.59
2.98
3.7
3.3
2.35
2.36
mmol/l
0.23
81
578
72
494
1.64
2.98
2.4
3.1
328.37
6407.76
umol/l
2.29
62
434
33
181
1.95
2.90
1.7
2.5
30.08
28.21
u/l
0.29
26
151
36
206
1.87
2.80
7.9
10.7
1.07
1.08
mmol/l
0.00
27
163
92
682
1.54
2.72
3.0
3.4
29.17
31.60
u/l
0.54
87
645
16
68
2.44
2.61
1.4
1.2
—
—
—
0
0
25
130
2.02
2.56
1.3
1.3
—
29.36
—
0
10
50
328
1.65
2.44
1.9
1.6
912.98
1221.27
nmol/l
2.27
34
250
46
296
1.68
2.42
2.1
1.9
—
—
—
0
0
73
528
1.54
2.37
1.7
1.6
1.34
1.34
mmol/l
0.01
67
449
70
508
1.52
2.23
2.4
2.0
2.36
3.02
mg/l
2.36
61
431
5
9
5.64
2.22
1.0
1.7
—
—
—
0
0
52
353
1.59
2.21
1.3
1.3
18.22
11.21
u/ml
0.22
15
148
52
354
1.59
2.19
2.4
2.3
—
—
—
0
0
53
363
1.58
2.18
1.4
1.3
12.21
32.55
iu/ml
3.10
19
127
23
125
1.92
2.10
2.2
1.5
—
—
—
0
0
63
454
1.51
2.06
1.7
1.5
21.36
21.03
nmol/l
0.06
56
383
172
1501
1.44
2.02
3.7
3.4
—
—
—
0
0
16
77
2.15
2.01
1.3
2.1
—
—
—
0
0
228
2119
1.69
1.89
18.4
12.8
24.31
22.28
mg/l
0.39
186
1627
22
123
1.86
1.87
1.4
1.4
—
—
—
0
0
47
325
1.55
1.85
2.1
2.1
—
—
—
0
0
236
2218
1.82
1.82
10.9
9.8
25.63
26.30
u/l
0.23
231
2148
123
1025
1.38
1.81
3.5
3.5
0.00
0.00
estimate
-0.00
19
221
24
140
1.79
1.79
4.0
3.8
64.95
66.33
g/l
0.33
19
129
162
1415
1.39
1.78
3.2
3.0
37.73
42.05
u/l
0.45
154
1333
123
1027
1.38
1.78
4.6
4.8
0.00
0.00
estimate
-0.00
19
213
26
156
1.74
1.77
1.2
1.2
199.44
153.91
iu/ml
—
9
63
12
54
2.28
1.77
1.4
1.2
—
—
—
0
0
124
1039
1.38
1.75
3.7
3.5
0.00
0.01
estimate
0.50
14
205
13
63
2.12
1.62
1.5
1.4
—
—
—
0
0
212
1955
1.49
1.62
5.9
4.6
1.79
1.88
mu/l
0.69
202
1786
10
44
2.32
1.57
1.7
2.1
22.69
24.24
mmol/l
—
10
44
116
980
1.34
1.48
3.3
2.6
96.25
98.92
ug/l
0.08
111
891
7
28
2.54
1.46
1.0
1.1
—
—
—
0
0
45
325
1.47
1.46
2.2
2.5
2.42
2.44
mmol/l
0.49
33
287
9
39
2.35
1.44
1.2
1.2
—
—
—
0
0
9
39
2.35
1.44
1.2
1.2
—
—
—
0
0
6
22
2.77
1.44
1.2
1.1
—
—
—
0
0
6
22
2.77
1.44
1.2
1.1
—
—
—
0
0
115
983
1.31
1.31
2.7
2.6
—
—
—
0
0
5
18
2.81
1.29
1.4
1.2
—
—
—
0
0
6
25
2.43
1.25
1.0
1.4
—
—
—
0
0
6
25
2.43
1.25
1.0
1.4
0.30
0.44
nmol/l
—
6
20
8
37
2.20
1.22
1.3
1.1
—
—
—
0
0
15
86
1.79
1.22
1.3
1.4
—
—
—
0
0
15
86
1.79
1.22
1.3
1.4
—
—
—
0
0
15
86
1.79
1.22
1.3
1.4
—
—
—
0
0
15
86
1.79
1.22
1.3
1.4
—
—
—
0
0
20
125
1.65
1.22
4.8
3.5
4.36
4.63
pmol/l
0.93
20
108
21
133
1.63
1.22
4.6
6.0
0.69
1.53
mmol/l
0.61
15
100
14
81
1.77
1.11
1.6
1.7
—
—
—
0
0
7
31
2.29
1.11
1.1
1.1
—
—
—
0
0
5
21
2.41
1.09
1.2
1.2
—
—
—
0
0
29
204
1.48
1.09
2.1
2.1
—
—
—
0
0
7
32
2.22
1.09
1.1
1.4
6.56
7.65
mmol/l
—
7
25
12
67
1.83
1.06
1.3
1.1
—
—
—
0
0
15
236
0.61
1.03
12.7
6.6
—
—
—
0
0
195
1824
1.29
0.95
5.8
5.3
38.84
39.18
mmol/mol
0.21
184
1711
35
263
1.38
0.94
2.7
2.3
22.14
21.83
%
0.06
28
230
84
718
1.25
0.91
3.7
3.7
106.51
35.39
ng/l
0.41
46
473
60
493
1.28
0.89
2.5
2.4
—
—
—
0
0
18
120
1.54
0.88
1.3
1.4
—
—
—
0
0
200
1884
1.28
0.88
21.2
15.3
14.10
14.59
%
0.84
194
1862
6
31
1.96
0.85
4.0
8.9
—
248.88
—
0
8
26
190
1.41
0.83
4.0
5.3
1.09
1.68
mmol/l
0.30
19
148
202
1910
1.27
0.82
14.0
11.5
86.93
85.17
ml/min/173m2
0.46
169
1545
8
48
1.69
0.79
1.0
1.6
—
—
—
0
0
16
107
1.53
0.78
2.2
1.8
—
—
—
0
0
6
34
1.78
0.77
4.0
1.6
—
—
—
0
0
9
53
1.72
0.76
4.2
2.7
—
—
—
0
0
206
1961
1.26
0.73
4.5
4.2
5.79
5.81
mmol/l
0.10
193
1794
7
41
1.73
0.70
1.1
1.2
—
—
—
0
0
12
77
1.59
0.70
1.3
2.3
1.49
1.47
g/l
0.02
12
66
46
378
1.26
0.69
1.8
1.7
186842484.32
452.54
pmol/l
0.49
38
314
63
542
1.22
0.64
4.1
3.8
15.75
13.86
mg/mmol
0.08
39
335
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.7
—
—
—
0
0
16
116
1.40
0.56
4.6
2.3
33.19
42.69
u/ml
0.19
16
110
56
483
1.20
0.55
5.7
4.7
2.35
2.00
ug/l
0.36
50
421
46
389
1.22
0.55
5.0
4.2
21.31
21.95
%
0.11
23
185
14
99
1.44
0.55
1.4
1.5
—
—
—
0
0
12
83
1.47
0.53
2.3
1.6
—
—
—
0
0
207
1994
1.20
0.51
4.6
4.1
4.81
4.69
mmol/l
0.90
196
1860
29
235
1.26
0.51
7.5
6.5
103.79
104.23
mmol/l
0.21
29
235
210
2027
1.20
0.50
5.2
4.5
2.82
2.78
mmol/l
0.26
199
1874
7
45
1.57
0.49
2.9
1.5
—
—
—
0
0
17
128
1.35
0.49
6.6
8.8
24.74
24.82
mmol/l
0.04
17
128
199
1915
1.18
0.47
4.0
3.7
1.29
1.26
mmol/l
0.27
189
1767
7
48
1.47
0.47
1.7
1.4
—
—
—
0
0
15
113
1.35
0.43
1.3
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
32.75
—
0
8
0
15
0.00
0.41
0.0
1.0
—
535.33
—
0
9
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
205
1985
1.16
0.40
4.5
4.1
1.50
1.50
mmol/l
0.04
192
1838
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
57
509
1.15
0.39
3.1
3.5
1590.34
1098.11
ng/l
0.27
45
421
9
66
1.38
0.39
1.6
2.2
—
—
—
0
0
21
170
1.26
0.38
1.7
1.9
—
—
—
0
0
5
79
0.63
0.36
1.4
1.7
—
—
—
0
0
6
86
0.69
0.33
2.2
1.6
—
—
—
0
0
7
52
1.36
0.31
1.1
1.4
—
43.93
—
0
7
46
416
1.13
0.27
1.7
1.5
—
—
—
0
0
24
208
1.17
0.25
1.7
1.6
—
—
—
0
0
5
39
1.29
0.23
1.4
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
5.83
—
0
10
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
3.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
198.83
—
0
13
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
3.5
—
—
—
0
0
0
14
0.00
0.20
0.0
3.5
—
—
—
0
0
6
50
1.20
0.20
1.7
1.5
—
—
—
0
0
7
61
1.15
0.17
1.4
1.4
—
8.46
—
0
14
8
69
1.16
0.16
2.1
1.9
0.73
5.04
ug/l
—
8
64
240
2380
1.13
0.13
26.1
19.1
39.41
40.24
%
1.08
226
2251
5
48
1.04
0.09
1.4
1.3
—
—
—
0
0
8
78
1.03
0.07
1.9
1.3
—
—
—
0
0
8
90
0.89
0.07
1.4
1.9
—
—
—
0
0
17
179
0.95
0.03
1.3
1.5
—
—
—
0
0
78
791
0.98
0.03
3.7
3.5
—
—
—
0
0
50
509
0.98
0.02
2.1
1.7
—
—
—
0
0
55
556
0.99
0.00
3.9
3.6
0.00
0.00
estimate
0.50
17
211
28
282
0.99
0.00
3.0
2.8
0.74
0.74
ug/l
0.00
21
182
19
191
0.99
0.00
1.9
4.4
2.55
40.35
ug/l
0.56
11
162
25
247
1.01
0.00
3.8
4.3
30.53
31.70
%
0.22
19
168
19
193
0.98
0.00
3.2
3.3
—
—
—
0
0
15
147
1.02
0.00
3.9
2.7
56.40
68.79
ml/min/173m2
—
10
62
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
1884.78
—
0
9
0
8
0.00
0.00
0.0
1.3
—
9.28
—
0
8
5
50
1.00
-0.00
1.4
1.3
—
1.08
—
0
5
7
73
0.96
-0.00
1.6
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1.35
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
5.86
—
0
5
7
76
0.92
-0.00
1.7
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
9.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.0
—
195.86
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint INCREASEDMUSCLETONE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| INCREASEDMUSCLETONE | 1.498 [1.12, 2.01] | 0.006 |
| Birth year | 0.997 [0.99, 1.01] | 0.455 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 1243 females with INCREASEDMUSCLETONE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| INCREASEDMUSCLETONE | 1.505 [1.12, 2.02] | 0.006 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 122 out of 1128 males with INCREASEDMUSCLETONE died.
Mortality risk
Mortality risk for people of age
years, who have INCREASEDMUSCLETONE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.187% | 0.339% |
| 5 | 0.974% | 1.718% |
| 10 | 2.335% | 4.324% |
| 15 | 4.498% | 8.337% |
| 20 | 7.859% | 13.408% |
Relationships between endpoints
↥Index endpoint: INCREASEDMUSCLETONE – Increased muscle tone
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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