Risteys · SLE

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M32.8 Cause of death: ICD-10 — M32.8 2 out of 7 registries used, show all original rules.	303
4. Check minimum number of events None	303
5. Include endpoints None	303
6. Filter based on genotype QC (FinnGen only)	303

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1584	1344	221
Only index persons	1393	1210	183
Unadjusted period prevalence (%)
Whole population	0.03	0.04	0.01
Only index persons	0.04	0.04	0.01
Median age at first event (years)
Whole population	48.85	48.53	50.99
Only index persons	47.72	47.64	48.24

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	303	265	38
Unadjusted period prevalence (%)	0.08	0.09	0.02
Median age at first event (years)	45.16	44.20	51.85

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
276: Matched controls
2759

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M32.8

ICD-10 Finland

Other forms of systemic lupus erythematosus

+∞

323.0

270

M32.9

ICD-10 Finland

Systemic lupus erythematosus, unspecified

+∞

288.8

224

P01BA02

ATC

hydroxychloroquine; oral

111.6

205.4

233

127

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

60.8

170.5

225

186

M32.1

ICD-10 Finland

Systemic lupus erythematosus with organ or system involvement

+∞

99.1

L04AX01

ATC

azathioprine; systemic

35.5

92.3

122

M32.0

ICD-10 Finland

Drug-induced systemic lupus erythematosus

+∞

90.7

7100A

ICD-9 Finland

Diffuse diseases of connective tissue, Systemic lupus erythematosus

+∞

79.0

M32

ICD-10 Finland

Systemic lupus erythematosus

+∞

56.2

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

14.4

55.8

102

108

L04AA06

ATC

mycophenolic acid; systemic

42.5

54.9

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

11.2

51.0

107

147

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

7.0

48.8

189

656

H02AB06

ATC

prednisolone; systemic

7.7

48.7

223

971

M35.9

ICD-10 Finland

Systemic involvement of connective tissue, unspecified

68.2

48.6

H02AB07

ATC

prednisone; oral

8.0

44.6

120

243

73410

ICD-8 Finland

Diffuse diseases of connective tissue, Systemic lupus erythematosus

502.8

44.5

M05BA04

ATC

alendronic acid; oral

9.9

39.4

120

L93.0

ICD-10 Finland

Discoid lupus erythematosus

212.6

36.7

N08.5*M32.1

ICD-10 Finland

Glomerular disorders in systemic lupus erythematosus

+∞

35.2

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

8.2

32.8

131

R50.9

ICD-10 Finland

Fever, unspecified

6.5

29.5

179

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

7.3

28.9

137

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

7.2

26.2

119

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

10.7

25.7

M35.1

ICD-10 Finland

Other overlap syndromes

59.5

23.5

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.7

23.4

159

742

H02AB04

ATC

methylprednisolone; systemic

4.8

23.2

248

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

8.4

22.4

C08CA05

ATC

nifedipine; systemic

7.7

21.4

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

14.1

21.1

L88

ICPC

Rheumatoid/seropositive arthritis

9.8

20.8

L04AA01

ATC

[U] ciclosporin; systemic

20.6

19.1

ZX120

NOMESCO Finland

Intravenous

5.4

18.0

130

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

4.7

17.9

172

B01AA03

ATC

warfarin; systemic

4.3

17.6

213

G73.7*M32.1

ICD-10 Finland

Myopathy in systemic lupus erythematosus

+∞

16.8

D68.8

ICD-10 Finland

Other specified coagulation defects

28.2

15.8

N08.5

ICD-10 Finland

Glomerular disorders in systemic connective tissue disorders

+∞

15.8

Z01.0

ICD-10 Finland

Examination of eyes and vision

3.6

15.7

288

P01BA01

ATC

chloroquine; systemic

40.6

15.6

J99.1*M32.1

ICD-10 Finland

Respiratory disorders in systemic: lupus erythematosus

+∞

14.7

KA3AT

NOMESCO Finland

Biopsy of kidney with ultrasound guidance

38.3

14.6

XX9XE

NOMESCO Finland

Other ultrasound examination

18.3

14.6

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

3.8

14.3

209

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

4.8

14.0

119

TPH04

NOMESCO Finland

Cathetrisation of vein

3.3

14.0

311

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

3.5

14.0

268

A02BC01

ATC

omeprazole; systemic

3.0

13.8

101

448

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.9

13.7

105

478

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

2.6

13.2

146

827

F02.89*M32.8

ICD-10 Finland

Dementia in systemic lupus erythematosus

+∞

12.6

G05.8*M32.1

ICD-10 Finland

Encephalitis in systemic lupus erythematosus

+∞

12.6

N02AX02

ATC

tramadol; systemic, rectal

2.6

12.6

137

761

J05AB11

ATC

valaciclovir; oral

3.4

12.5

237

L04AD01

ATC

ciclosporin; systemic

11.3

12.0

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

7.5

12.0

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

3.8

11.9

167

D69.6

ICD-10 Finland

Thrombocytopenia, unspecified

17.4

11.8

R06.0

ICD-10 Finland

Dyspnoea

2.8

11.8

411

J05AB01

ATC

aciclovir; systemic

2.8

11.8

398

B02.9

ICD-10 Finland

Zoster without complication

5.8

11.6

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

5.1

11.6

A49.9

ICD-10 Finland

Bacterial infection, unspecified

4.3

11.6

116

C03CA01

ATC

furosemide; systemic

2.9

11.5

360

J01MA12

ATC

levofloxacin; systemic

3.1

11.5

270

Z3231

NOMESCO Finland

Registered nurse

2.7

11.4

469

M05BA07

ATC

risedronic acid; oral

6.8

11.3

TNX00

NOMESCO Finland

Puncture and needle biopsy of soft tissue, unspecified region

14.7

11.1

R4120

NOMESCO Finland

Occupational therapy

5.1

11.1

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

6.5

10.9

B01AB05

ATC

enoxaparin; parenteral

2.5

10.7

102

516

73491

ICD-8 Finland

Diffuse diseases of connective tissue, Collagenosis NUD

+∞

10.5

1XC02

NOMESCO Finland

33.9

10.4

D07AB08

ATC

desonide; topical

3.4

10.4

186

B07.9

ICD-10 Finland

Verruca simplex

6.6

10.3

E0000UV

ATC

2.3

10.3

139

839

J01FF01

ATC

clindamycin; systemic

2.5

10.1

104

543

J01FA06

ATC

roxithromycin; oral

2.3

9.9

137

829

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.8

9.9

323

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

5.9

9.5

L01BB01

ATC

+∞

9.4

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

3.5

9.4

151

A02BC02

ATC

pantoprazole; systemic

2.3

9.4

195

1413

J15.9

ICD-10 Finland

Bacterial pneumonia, unspecified

4.4

9.1

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

3.3

9.0

171

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

4.3

9.0

ZXD30

NOMESCO Finland

Difficulties in perfomrming procedure

5.2

9.0

L01AA01

ATC

cyclophosphamide; systemic

51.6

8.7

NH1AE

NOMESCO Finland

Ankle joint ultrasound examination

51.6

8.7

M05BB03

ATC

alendronic acid and colecalciferol; oral

7.3

8.7

L98.9

ICD-10 Finland

Disorder of skin and subcutaneous tissue, unspecified

12.1

8.7

B99

ICD-10 Finland

Other and unspecified infectious diseases

12.1

8.7

N32.9

ICD-10 Finland

Bladder disorder, unspecified

28.5

8.5

R2130

NOMESCO Finland

Counselling and guidance which enhance independent living

4.0

8.5

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

5.6

8.5

J90

ICD-10 Finland

Pleural effusion, not elsewhere classified

7.5

8.4

7108X

ICD-9 Finland

Diffuse diseases of connective tissue, Other specified diffuse diseases of connective tissue

+∞

8.4

E000001

ATC

2.5

8.3

376

A02BC03

ATC

lansoprazole; oral

2.3

8.3

529

L30.9

ICD-10 Finland

Dermatitis, unspecified

2.6

8.2

278

D07AC01

ATC

betamethasone; topical

2.2

8.1

110

642

A02BC05

ATC

esomeprazole; systemic

2.1

8.1

126

784

ND2DA

NOMESCO Finland

Bilateral hand X-ray examination

8.9

7.9

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

7.3

7.9

A04.7

ICD-10 Finland

Enterocolitis due to Clostridium difficile

11.3

7.9

O99.89

ICD-10 Finland

Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium

7.8

Z3226

NOMESCO Finland

Physiotherapist

2.5

7.7

315

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

6.5

7.7

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.0

7.7

140

923

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

3.4

7.6

116

Z3229

NOMESCO Finland

Other healthcare associate professional

3.5

7.5

111

XPX04

NOMESCO Finland

Angioscopy

82.2

7.5

Z2221

NOMESCO Finland

Medical doctor

2.2

7.4

538

69540

ICD-8 Finland

Erythematous condition, Lupus erythematosus

+∞

7.3

L93.1

ICD-10 Finland

Subacute cutaneous lupus erythematosus

+∞

7.3

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

3.3

7.3

125

J01MA14

ATC

moxifloxacin; systemic

3.2

7.3

131

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

4.8

7.3

S01AX11

ATC

[U] ofloxacin; ophthalmic

6.9

7.2

A41.9

ICD-10 Finland

Sepsis, unspecified

5.9

7.2

M05BA01

ATC

etidronic acid; systemic

30.9

7.2

C08CA01

ATC

amlodipine; oral

2.2

7.1

489

Z01.8

ICD-10 Finland

Other specified special examinations

2.3

7.1

386

J01MA02

ATC

ciprofloxacin; systemic

2.0

7.1

111

683

NF1AA

NOMESCO Finland

Hip X-ray examination

3.4

7.1

105

L04AA13

ATC

leflunomide; oral

5.7

7.1

Z50.1

ICD-10 Finland

Other physical therapy

4.1

7.0

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

3.4

7.0

106

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

2.5

7.0

280

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

4.8

6.9

H26.3

ICD-10 Finland

Drug-induced cataract

14.2

6.9

N02AA05

ATC

oxycodone; systemic

2.7

6.9

194

205

Kela drug reimbursment

Chronic hypertension

2.3

6.8

342

G73.7

ICD-10 Finland

Myopathy in other diseases classified elsewhere

41.1

6.8

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

4.1

6.8

L99

ICPC

Musculoskeletal disease other

6.2

6.7

D02BB01

ATC

betacarotene; oral

23.2

6.7

M05BX04

ATC

denosumab; parenteral

4.1

6.7

FB1BD

NOMESCO Finland

Extensive CT examination of arteria pulmonalis

3.3

6.7

110

A07AA02

ATC

nystatin; oral

3.5

6.7

M81.9

ICD-10 Finland

Osteoporosis, unspecified

4.7

6.6

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

3.9

6.6

XCK00

NOMESCO Finland

Perimetry

3.6

6.6

C02CA01

ATC

prazosin; oral

14.7

6.4

J01DB01

ATC

cefalexin; oral

2.3

6.4

238

2007

WZC05

NOMESCO Finland

Specialty-specific consultation based on referral by dentist or doctor

3.9

6.4

R4110

NOMESCO Finland

Physiotherapy

2.1

6.3

487

ZXE04

NOMESCO Finland

Procedure duration 30 to 39 minutes

3.7

6.3

M34.9

ICD-10 Finland

Systemic sclerosis, unspecified

18.5

6.3

N08.5*M31.1

ICD-10 Finland

Glomerular disorders in thrombotic thrombocytopenic purpura

+∞

6.3

6BA02

NOMESCO Finland

27.3

6.3

UJF30

NOMESCO Finland

Ileoscopy through colon

2.9

6.2

140

H53.1

ICD-10 Finland

Subjective visual disturbances

3.4

6.2

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

2.7

6.2

171

B01AB04

ATC

dalteparin; parenteral

4.4

6.2

XF400

NOMESCO Finland

ECG with 12 standard connections

2.5

6.1

225

H26.2

ICD-10 Finland

Complicated cataract

12.9

6.1

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

5.4

6.1

N02AJ06

ATC

codeine and paracetamol; systemic

1.9

6.1

111

710

A46

ICD-10 Finland

Erysipelas

2.8

6.1

154

S01BA04

ATC

prednisolone; ophthalmic (corticosteroids, plain)

5.8

6.1

M01AH02

ATC

rofecoxib; oral

2.6

6.1

181

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

3.1

6.0

107

Mortality – FinRegistry

↥

Association

Association between endpoint SLE_OTH and mortality.

Females

Parameter	HR [95% CI]	p-value
SLE_OTH	2.654 [2.26, 3.11]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.168

During the follow-up period (1.1.1998 — 31.12.2019), 283 out of 1188 females with SLE_OTH died.

Males

Parameter	HR [95% CI]	p-value
SLE_OTH	2.679 [1.67, 4.29]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.01

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 186 males with SLE_OTH died.

Mortality risk

Mortality risk for people of age

years, who have SLE_OTH.

N-year risk	Females	Males
1	0.202%	0.566%
5	1.436%	2.969%
10	3.668%	7.89%
15	7.028%	14.305%
20	12.148%	23.574%

Relationships between endpoints

↥

Index endpoint: SLE_OTH – Other forms of systemic lupus erythematosus

GWS hits: 2

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	SLE_OTH
CONTROL_EXCLUDE	SLE_FG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M328
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M328
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Other forms of systemic lupus erythematosus

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints