No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
313 |
4. Check minimum number of eventsNone |
313 |
5. Include endpointsNone |
313 |
6. Filter based on genotype QC (FinnGen only) |
299 |
Control definitions (FinnGen only)
- Control exclude
- SLE_FG
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M32
- Name in latin
- Aliae formae lupi erythematosi disseminati (LED)
Similar endpoints
↥List of similar endpoints to
Other forms of systemic lupus erythematosus
based on the number of shared cases.
Similar with more cases:
- SLE, strict definition
- SLE, ICD10
- Systemic lupus erythematosus
- SLE (Finngen)
- Systemic connective tissue disorders
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1584 | 1344 | 221 |
| Only index persons | 1393 | 1210 | 183 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.01 |
| Only index persons | 0.04 | 0.04 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 48.85 | 48.53 | 50.99 |
| Only index persons | 47.72 | 47.64 | 48.24 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 299 | 264 | 35 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.02 |
| Median age at first event (years) | 45.57 | 44.64 | 52.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 313
- Matched controls
- 3130
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
+∞
320.7
250
*
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
307.7
306
*
P01BA02
ATC
hydroxychloroquine; oral
96.0
307.7
262
159
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
62.9
303.7
252
193
L04AX01
ATC
azathioprine; systemic
57.9
224.7
136
41
L04AA06
ATC
mycophenolic acid; systemic
61.4
143.4
82
18
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
16.2
116.0
119
114
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
108.9
98
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
101.8
92
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
44.3
99.7
61
17
L04AX03
ATC
methotrexate; systemic
10.8
85.6
117
164
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
82.0
75
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
11.2
72.4
89
107
H02AB07
ATC
prednisone; oral
8.3
72.3
130
247
M05BA04
ATC
alendronic acid; oral
10.1
71.8
98
135
M32
ICD-10 Finland
Systemic lupus erythematosus
+∞
67.1
62
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.7
67.0
224
772
L01BA01
ATC
methotrexate; systemic
18.9
65.6
55
35
H02AB06
ATC
prednisolone; systemic
8.4
58.0
256
1091
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.2
55.7
89
145
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
8.1
49.5
77
121
L88
ICPC
Rheumatoid/seropositive arthritis
11.3
48.3
55
58
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
533.4
47.6
46
*
C08CA05
ATC
nifedipine; systemic
9.7
43.7
56
69
L93.0
ICD-10 Finland
Discoid lupus erythematosus
104.8
42.0
45
5
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
13.3
41.1
41
35
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
39.4
37
*
H02AB04
ATC
methylprednisolone; systemic
4.9
34.7
100
276
R50.9
ICD-10 Finland
Fever, unspecified
4.8
34.5
101
282
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
7.0
32.3
54
90
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.9
31.0
194
917
M35.1
ICD-10 Finland
Other overlap syndromes
114.3
29.2
31
*
ZX120
NOMESCO Finland
Intravenous
5.2
29.0
70
165
B01AA03
ATC
warfarin; systemic
4.5
27.1
82
231
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.5
25.7
76
210
L04AA01
ATC
[U] ciclosporin
47.2
25.1
30
7
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.7
24.2
105
379
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.8
22.3
83
269
L04AD01
ATC
ciclosporin; systemic
21.1
19.9
29
15
TPH04
NOMESCO Finland
Cathetrisation of vein
3.3
19.7
101
399
XX9XE
NOMESCO Finland
Other ultrasound examination
28.2
19.5
26
10
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
6.6
18.5
31
51
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.0
18.0
58
168
J01FF01
ATC
clindamycin; systemic
2.9
18.0
124
575
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
18.0
126
590
J99.1*M32.1
ICD-10 Finland
Respiratory disorders in systemic: lupus erythematosus
+∞
17.9
17
*
G73.7*M32.1
ICD-10 Finland
Myopathy in systemic lupus erythematosus
+∞
17.9
17
*
M05BA07
ATC
risedronic acid; oral
7.1
17.8
28
43
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
6.3
17.0
30
52
B07.9
ICD-10 Finland
Verruca simplex
6.4
16.8
29
49
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
7.8
16.8
24
33
C03CA01
ATC
furosemide; systemic
2.9
16.5
107
477
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.0
16.5
97
410
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.9
15.9
52
152
F02.89*M32.8
ICD-10 Finland
Dementia in systemic lupus erythematosus
+∞
15.8
15
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.9
15.3
94
405
A02BC02
ATC
pantoprazole; systemic
3.0
15.2
244
1691
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.5
15.1
59
194
P01BA01
ATC
chloroquine; systemic
33.6
15.0
19
6
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
14.7
14
*
G05.8*M32.1
ICD-10 Finland
Encephalitis in systemic lupus erythematosus
+∞
14.7
14
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.5
14.7
57
187
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.9
14.6
34
76
J01MA12
ATC
levofloxacin; systemic
3.0
14.6
81
329
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
20.4
14.4
21
11
Z3231
NOMESCO Finland
Registered nurse
2.6
14.1
116
576
R06.0
ICD-10 Finland
Dyspnoea
2.6
14.0
109
527
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.1
14.0
42
115
A02BC01
ATC
omeprazole; systemic
2.6
13.9
114
565
J05AB11
ATC
valaciclovir; oral
2.9
13.9
80
331
D07AB08
ATC
desonide; topical
3.2
13.6
61
218
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
13.6
94
427
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.5
13.6
173
1049
D68.8
ICD-10 Finland
Other specified coagulation defects
12.3
13.5
24
21
M05BX04
ATC
denosumab; parenteral
4.5
13.3
34
82
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.8
13.3
25
46
E0000UV, ,
ATC
2.4
13.3
169
1021
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.8
13.0
43
126
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
5.7
13.0
25
47
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.7
12.7
31
72
N02AX02
ATC
tramadol; systemic, rectal
2.4
12.7
157
931
R4120
NOMESCO Finland
Occupational therapy
3.9
12.4
39
110
B01AB05
ATC
enoxaparin; parenteral
2.4
12.4
122
652
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.1
12.2
58
214
D07AC01
ATC
betamethasone; topical
2.4
12.2
140
800
XQ848
NOMESCO Finland
Dermatological photography
6.2
12.0
21
36
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.6
11.8
42
129
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.8
11.8
39
114
Z3229
NOMESCO Finland
Other healthcare associate professional
3.6
11.7
42
130
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.8
11.5
38
111
NF1AA
NOMESCO Finland
Hip X-ray examination
3.7
11.5
39
116
M05BB03
ATC
alendronic acid and colecalciferol; oral
9.1
11.2
23
27
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
6.0
11.2
20
35
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.5
10.9
83
391
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
4.0
10.9
32
86
L95
ICPC
Osteoporosis
5.1
10.7
23
48
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.0
10.6
31
83
WZC00
NOMESCO Finland
Treatment plan or consultation
2.2
10.6
136
804
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
8.7
10.5
22
27
L93.1
ICD-10 Finland
Subacute cutaneous lupus erythematosus
+∞
10.5
10
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
11.2
10.4
19
18
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.4
10.4
27
66
A07AA02
ATC
nystatin; oral
3.8
10.4
33
94
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.7
10.3
34
99
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
10.2
77
360
J01FA06
ATC
roxithromycin; oral
2.2
10.0
153
963
205
Kela drug reimbursment
Chronic hypertension
2.4
10.0
80
385
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
17.4
10.0
15
9
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.1
9.9
28
73
1XC02, ,
NOMESCO Finland
27.0
9.9
13
5
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.2
9.8
27
69
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.1
9.8
43
151
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.7
9.8
32
93
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.1
9.7
44
157
L01AA01
ATC
cyclophosphamide; systemic
56.8
9.7
11
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
9.7
54
217
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
9.6
9.7
19
21
B02.9
ICD-10 Finland
Zoster without complication
3.5
9.6
35
109
Z3226
NOMESCO Finland
Physiotherapist
2.4
9.5
77
371
R4190
NOMESCO Finland
Nutritional therapy
4.6
9.5
23
53
H26.3
ICD-10 Finland
Drug-induced cataract
18.2
9.5
14
8
D02AX
ATC
Other emollients and protectives
5.4
9.5
19
37
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
5.4
9.5
19
37
N32.9
ICD-10 Finland
Bladder disorder, unspecified
31.1
9.5
12
*
E000001, ,
ATC
2.4
9.5
84
422
73491
ICD-8 Finland
Diffuse diseases of connective tissue, Collagenosis NUD
103.0
9.5
10
*
L01BB01, ,
ATC
103.0
9.5
10
*
J01MA02
ATC
ciprofloxacin; systemic
2.1
9.4
132
798
UJF30
NOMESCO Finland
Ileoscopy through colon
2.9
9.3
46
173
R4110
NOMESCO Finland
Physiotherapy
2.2
9.3
104
576
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
10.5
9.1
17
17
L04AA13
ATC
[U] leflunomide
7.8
9.1
20
27
A02BC03
ATC
lansoprazole; oral
2.2
9.1
107
604
Z50.1
ICD-10 Finland
Other physical therapy
3.8
9.1
28
78
J05AB01
ATC
aciclovir; systemic
2.2
9.0
100
550
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.2
9.0
24
60
H04.10
ICD-10 Finland
Dry eye syndrome
2.6
8.9
59
258
XCK00
NOMESCO Finland
Perimetry
3.6
8.9
31
94
C08CA01
ATC
amlodipine; oral
2.1
8.8
117
689
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
4.2
8.8
24
61
B01AB04
ATC
dalteparin; parenteral
4.2
8.8
24
61
318
Kela drug reimbursment
Teriparatide
51.5
8.7
10
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
12.0
8.7
15
13
Z2221
NOMESCO Finland
Medical doctor
2.1
8.7
110
637
A41.9
ICD-10 Finland
Sepsis, unspecified
6.7
8.6
21
33
L28
ICPC
Limited function/disability (L)
2.5
8.6
64
296
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.8
8.5
45
175
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.3
8.5
33
107
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.3
8.5
33
107
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
92.4
8.5
9
*
6BA02, ,
NOMESCO Finland
92.4
8.5
9
*
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
13.3
8.5
14
11
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
8.4
54
233
G73.7
ICD-10 Finland
Myopathy in other diseases classified elsewhere
+∞
8.4
8
*
7108X
ICD-9 Finland
Diffuse diseases of connective tissue, Other specified diffuse diseases of connective tissue
+∞
8.4
8
*
J01MA06
ATC
norfloxacin; oral
2.4
8.3
64
300
H53.1
ICD-10 Finland
Subjective visual disturbances
3.2
8.3
34
114
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.0
8.2
154
1024
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.6
8.1
28
84
H05AA02
ATC
teriparatide; parenteral
34.3
8.1
10
*
N18.0
ICD-10 Finland
End-stage renal disease
34.3
8.1
10
*
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
22.7
8.1
11
5
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.9
8.1
24
65
I35.0
ICD-10 Finland
Aortic (valve) stenosis
4.1
8.0
22
56
N02AA05
ATC
oxycodone; systemic
2.4
8.0
60
278
Z2446
NOMESCO Finland
Social worker
3.2
7.9
32
107
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
11.2
7.9
14
13
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.6
7.9
27
81
J01MA14
ATC
moxifloxacin; systemic
2.9
7.8
38
141
L99
ICPC
Musculoskeletal disease other
6.7
7.8
19
30
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.1
7.8
35
124
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
2.5
7.8
52
228
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.7
7.7
25
72
H02AB09
ATC
hydrocortisone; systemic
6.5
7.7
19
31
D07AC13
ATC
mometasone; topical
2.0
7.7
107
637
EB1WA, ,
NOMESCO Finland
25.7
7.6
10
*
A46
ICD-10 Finland
Erysipelas
2.6
7.6
48
205
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
7.6
142
936
R23.3
ICD-10 Finland
Spontaneous ecchymoses
6.8
7.5
18
28
D07AD01
ATC
clobetasol; topical
2.3
7.5
68
342
C09AA02
ATC
enalapril; systemic
2.4
7.4
58
274
L93.2
ICD-10 Finland
Other local lupus erythematosus
+∞
7.3
7
*
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
7.3
7
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
3.4
7.3
27
85
N30.0
ICD-10 Finland
Acute cystitis
2.2
7.3
69
353
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.0
7.2
34
124
A02BC05
ATC
esomeprazole; systemic
1.9
7.2
142
948
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
8.2
7.2
15
19
SPAT1255
SPAT
Intravenous administration of medicine
3.3
7.2
27
86
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.6
7.2
44
185
UJD02
NOMESCO Finland
Gastroscopy
3.8
7.2
22
61
J01DB01
ATC
cefalexin; oral
2.5
7.1
274
2302
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
7.3
7.1
16
23
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.0
7.0
31
109
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
7.0
51
233
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
6.9
53
247
ZX140
NOMESCO Finland
Intra articular
14.2
6.9
11
8
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
14.2
6.9
11
8
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.9
6.9
34
127
M01AH02
ATC
rofecoxib; oral
2.4
6.9
49
221
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
11.3
6.9
12
11
XF404
NOMESCO Finland
Ambulatory ECG
2.9
6.8
34
128
A01AB09
ATC
miconazole; local oral
2.7
6.8
38
152
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.0
6.8
31
111
NH3AE
NOMESCO Finland
Feet ultrasound examination
41.0
6.8
8
*
XPX04
NOMESCO Finland
Angioscopy
41.0
6.8
8
*
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.5
6.8
43
184
I25.2
ICD-10 Finland
Old myocardial infarction
4.2
6.7
18
45
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
4.2
6.7
18
45
M81.4
ICD-10 Finland
Drug-induced osteoporosis
23.1
6.7
9
*
TQW80
NOMESCO Finland
Local dermatologic skincare
6.1
6.7
17
29
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.5
6.7
23
69
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
6.7
45
198
C02DE02, ,
ATC
12.6
6.6
11
9
A01AC01
ATC
triamcinolone; local oral
9.0
6.6
13
15
N18.8
ICD-10 Finland
Other chronic renal failure
9.0
6.6
13
15
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.6
6.6
18
34
M05BA06
ATC
ibandronic acid; systemic
6.4
6.6
16
26
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
5.9
6.5
17
30
J02AC01
ATC
fluconazole; systemic
1.8
6.5
163
1161
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
2.2
6.5
58
289
X58
ICD-10 Finland
Exposure to other specified factors
2.4
6.5
50
234
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.5
6.5
41
175
69540
ICD-8 Finland
Erythematous condition, Lupus erythematosus
71.2
6.4
7
*
A11CC03
ATC
alfacalcidol; systemic
6.8
6.4
15
23
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
6.2
6.4
16
27
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.9
6.4
108
680
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
11.3
6.3
11
10
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
11.3
6.3
11
10
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
6.3
63
328
N03AX16
ATC
[U] pregabalin
2.0
6.3
84
487
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
3.0
6.3
28
99
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.2
6.3
59
300
I32.8*M32.1
ICD-10 Finland
Pericarditis (in) systemic lupus erythematosus
+∞
6.3
6
*
N085, M328,
ICD-10 Finland
+∞
6.3
6
*
N16.4*M32.1
ICD-10 Finland
Renal tubulo-interstitial disorders in systemic lupus erythematosus
+∞
6.3
6
*
ZX108
NOMESCO Finland
Inhalation
27.3
6.3
8
*
WW200
NOMESCO Finland
Immunization
6.5
6.2
15
24
S97
ICPC
Chronic ulcer skin
3.1
6.2
26
89
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
6.1
53
260
Z49.1
ICD-10 Finland
Extracorporeal dialysis
12.9
6.1
10
8
PJA10
NOMESCO Finland
Exploration of lymph nodes
10.3
6.1
11
11
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
10.3
6.1
11
11
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
10.3
6.1
11
11
WX002
NOMESCO Finland
Sedation and analgesia
2.1
6.1
65
348
WX892
NOMESCO Finland
Monitored bed care
3.1
6.0
26
90
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
6.0
65
349
K11.2
ICD-10 Finland
Sialoadenitis
3.8
6.0
18
49
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
155
98
30.35
195.40
8.2
1.5
—
—
—
0
0
105
83
18.53
114.41
1.9
1.3
26.30
2.54
u/ml
—
40
9
104
85
17.83
111.05
1.9
1.2
20.77
3.80
u/ml
2.34
51
15
83
76
14.50
81.60
1.9
1.2
60.94
40.49
u/ml
—
26
7
57
49
14.00
57.47
1.4
1.2
10.06
6.33
u/ml
0.28
34
15
277
1338
10.31
52.82
16.8
5.0
1.61
1.98
e9/l
3.64
268
1199
278
1348
10.50
52.78
16.9
5.4
0.14
0.18
e9/l
6.16
269
1191
45
32
16.26
50.36
2.2
2.2
—
—
—
0
0
53
52
12.07
48.89
1.4
1.2
6.00
11.28
u/ml
0.42
38
18
280
1514
9.06
42.68
19.5
8.4
3.86
3.94
e9/l
0.23
269
1334
32
23
15.38
35.29
1.5
1.1
—
—
—
0
0
32
23
15.38
35.29
1.5
1.1
—
—
—
0
0
32
23
15.38
35.29
1.5
1.1
—
—
—
0
0
220
1141
4.12
30.45
3.7
2.3
82.16
77.30
nmol/l
1.73
213
1024
165
741
3.59
27.70
5.9
3.0
43.97
134.94
e6/l
0.50
148
567
182
875
3.58
27.31
7.0
2.9
—
—
—
0
0
199
1013
3.65
27.24
6.5
4.0
34.24
36.37
g/l
6.43
189
953
132
523
3.64
26.79
4.1
2.5
5.48
7.67
e6/l
0.67
125
475
149
669
3.34
24.27
5.8
2.8
0.43
0.40
e6/l
0.04
131
498
214
1205
3.45
23.60
11.9
5.9
1.22
1.22
mmol/l
0.02
191
1015
227
1334
3.55
23.14
7.7
3.5
0.00
0.00
estimate
-0.00
45
255
223
1315
3.42
22.20
7.7
3.5
0.00
0.00
estimate
-0.00
50
277
223
1321
3.39
21.91
11.1
4.8
0.00
0.00
estimate
0.50
45
262
151
729
3.07
21.02
2.5
2.0
111.87
257.38
u/l
0.92
145
686
32
22
16.06
19.88
1.5
1.1
—
—
—
0
0
32
22
16.06
19.88
1.5
1.1
—
—
—
0
0
85
302
3.49
19.67
4.1
2.3
18.95
22.49
%
1.86
78
257
59
172
3.99
18.20
1.9
3.0
65.79
67.22
g/l
0.66
54
153
93
382
3.04
16.64
4.9
2.5
1.94
1.05
e6/l
0.71
66
199
59
186
3.68
16.18
5.6
3.5
2.02
2.10
mmol/l
0.07
49
155
120
582
2.72
15.59
3.0
3.2
1365.41
985.76
ng/l
0.53
108
489
122
598
2.70
15.51
3.0
2.0
3.12
3.03
mg/l
0.15
115
511
87
360
2.96
15.22
5.4
2.7
2.39
4.06
e6/l
1.34
61
180
84
344
2.97
14.95
2.1
1.8
—
—
—
0
0
33
74
4.87
14.14
1.8
2.5
—
—
—
0
0
175
1057
2.49
13.97
28.7
11.2
1.40
1.17
inr
1.77
52
345
45
134
3.75
13.32
5.6
2.9
0.11
0.21
e6/l
0.55
45
128
49
159
3.47
12.74
1.6
1.7
—
—
—
0
0
18
9
21.12
12.60
2.5
2.3
—
—
—
0
0
23
23
10.70
12.21
1.1
1.1
—
—
—
0
0
173
1089
2.32
11.93
10.3
5.3
1.22
1.22
mmol/l
0.54
167
992
24
49
5.22
11.41
1.7
1.3
—
—
—
0
0
21
21
10.63
11.19
1.6
1.1
1.13
1.09
ratio
—
6
8
63
256
2.83
11.13
1.9
2.0
350.89
383.42
nmol/l
0.63
57
240
78
356
2.59
10.97
4.7
3.1
0.83
0.82
mmol/l
0.19
72
336
24
54
4.73
10.20
1.5
1.6
—
—
—
0
0
123
709
2.21
10.07
5.3
2.9
7.12
7.45
mmol/l
0.31
111
608
118
676
2.20
9.75
6.4
3.6
24.72
7.60
mg/mmol
1.15
91
399
28
74
4.06
9.73
1.7
1.5
0.16
0.01
iu/ml
—
6
11
23
54
4.52
9.29
1.4
1.9
—
—
—
0
0
19
38
5.26
9.21
1.2
1.6
—
—
—
0
0
191
1335
2.11
9.19
7.1
5.5
9.43
9.77
umol/l
0.33
185
1257
105
589
2.18
9.03
2.1
1.7
1.54
0.94
mg/l
1.23
86
458
17
18
9.92
8.89
1.5
2.2
—
—
—
0
0
22
52
4.48
8.81
1.4
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
53
4.39
8.60
2.8
2.5
0.34
0.35
u/ml
0.03
14
29
54
232
2.60
8.46
2.1
1.7
—
—
—
0
0
24
63
4.04
8.41
1.4
1.3
—
—
—
0
0
54
233
2.59
8.38
2.2
1.8
—
—
—
0
0
30
93
3.46
8.31
1.9
2.0
—
—
—
0
0
179
1251
2.01
8.27
4.2
2.8
122.50
79.35
ug/l
1.99
171
1164
28
85
3.52
8.00
2.1
1.9
—
—
—
0
0
155
1042
1.97
7.89
8.2
3.6
—
—
—
0
0
135
886
1.92
7.20
4.4
3.4
600.20
28.87
ng/l
0.52
94
556
17
39
4.55
7.05
1.3
1.6
—
—
—
0
0
14
17
8.56
6.90
1.5
2.2
—
—
—
0
0
26
85
3.25
6.63
1.3
1.4
—
—
—
0
0
20
55
3.82
6.58
6.5
4.0
59.70
57.73
%
0.27
20
55
76
424
2.05
6.37
4.9
3.5
365.31
150.72
ng/l
0.77
56
300
190
1429
1.84
6.30
6.9
4.1
6.18
6.46
mmol/l
1.28
183
1314
131
880
1.84
6.29
3.6
3.2
2.33
2.36
mmol/l
1.86
124
785
18
36
5.24
6.29
1.5
1.7
—
—
—
0
0
18
36
5.24
6.29
1.5
1.7
—
—
—
0
0
18
48
3.92
6.18
1.2
1.5
390.18
265.06
u/ml
0.48
11
28
19
54
3.68
5.98
6.7
3.5
3.52
4.54
e9/l
1.13
19
54
19
55
3.61
5.83
3.4
2.4
—
—
—
0
0
18
51
3.68
5.69
1.2
1.5
—
—
—
0
0
119
796
1.80
5.67
2.6
2.3
59.12
55.45
u/l
0.73
114
735
296
2644
3.20
5.67
33.8
12.1
17.16
20.81
mg/l
1.85
266
2031
97
616
1.83
5.45
4.1
2.6
8352.49
8869.77
umol/l
0.02
88
542
15
30
5.20
5.32
1.1
1.6
—
—
—
0
0
32
134
2.55
5.25
5.2
3.4
5.22
5.05
kpa
0.54
32
129
137
973
1.73
5.20
2.2
1.9
99.46
97.04
pmol/l
0.21
68
480
14
27
5.38
5.14
1.1
1.7
—
—
—
0
0
30
123
2.59
5.14
1.7
1.6
—
—
—
0
0
23
83
2.91
4.99
1.2
1.1
—
—
—
0
0
21
72
3.05
4.98
1.4
2.3
9.22
10.47
mg/l
0.40
21
66
22
78
2.96
4.93
5.4
4.2
1.60
1.58
%
0.03
22
72
15
34
4.58
4.81
1.2
1.6
—
—
—
0
0
91
586
1.78
4.80
6.3
3.7
1.02
1.02
kg/l
0.06
14
81
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
14
7.34
4.69
1.2
1.1
—
—
—
0
0
29
123
2.50
4.64
5.3
3.6
0.80
1.51
mmol/l
0.21
24
92
92
601
1.75
4.60
2.7
2.1
—
—
—
0
0
25
100
2.63
4.50
4.8
2.3
0.62
0.69
%
0.77
25
100
12
23
5.38
4.50
1.5
1.5
—
—
—
0
0
12
23
5.38
4.50
1.5
1.5
—
—
—
0
0
15
37
4.21
4.47
1.3
1.2
—
—
—
0
0
159
1210
1.64
4.43
3.2
2.4
—
—
—
0
0
35
166
2.25
4.39
1.7
2.4
8.47
5.47
ug/l
0.45
30
147
9
12
7.68
4.38
2.1
2.8
827.00
713.67
u/ml
—
9
12
75
468
1.79
4.36
3.6
2.5
2.46
2.45
mmol/l
0.24
68
410
8
9
9.08
4.30
1.1
1.1
—
—
—
0
0
13
29
4.63
4.29
1.1
1.0
—
—
—
0
0
47
253
2.01
4.27
11.2
5.6
104.72
104.21
mmol/l
0.22
47
253
12
25
4.95
4.23
1.3
1.4
—
—
—
0
0
66
401
1.82
4.18
1.9
1.7
1202.53
1274.31
nmol/l
0.25
54
297
7
7
10.19
4.03
2.9
2.1
49.36
153.43
ug/l
—
7
7
13
33
4.06
3.84
3.5
2.5
3.88
3.90
mmol/l
0.04
13
33
13
33
4.06
3.84
1.4
1.4
—
—
—
0
0
13
33
4.06
3.84
3.5
2.5
108.31
106.91
mmol/l
0.44
13
33
7
8
8.92
3.79
1.0
1.4
—
—
—
0
0
101
711
1.62
3.71
8.2
3.9
0.00
0.00
estimate
0.50
45
262
14
45
3.21
3.69
1.3
1.3
—
—
—
0
0
19
75
2.63
3.53
1.4
1.2
—
—
—
0
0
6
6
10.16
3.51
1.2
1.2
—
—
—
0
0
13
37
3.62
3.44
1.2
1.5
—
—
—
0
0
13
37
3.62
3.44
1.2
1.5
—
—
—
0
0
13
37
3.62
3.44
1.2
1.5
—
—
—
0
0
13
42
3.19
3.41
1.8
1.4
—
—
—
0
0
15
53
2.92
3.40
1.1
1.1
—
14.27
—
0
7
7
10
7.13
3.38
1.3
2.5
—
—
—
0
0
7
10
7.13
3.38
1.3
2.5
—
—
—
0
0
247
2168
1.66
3.32
4.5
4.3
14.63
14.53
pmol/l
0.27
237
1993
14
49
2.94
3.23
1.4
1.4
—
111.00
—
0
12
9
20
4.60
3.13
1.2
1.0
—
—
—
0
0
14
50
2.88
3.13
1.1
1.1
—
—
—
0
0
276
2509
1.85
3.12
25.4
11.1
83.74
84.62
ml/min/173m2
0.24
259
2028
27
134
2.11
3.06
1.8
1.3
—
—
—
0
0
11
31
3.64
3.02
1.2
1.0
—
—
—
0
0
9
21
4.38
3.01
1.2
1.7
12.86
11.84
umol/l
—
9
21
5
5
10.13
2.99
1.0
1.4
—
—
—
0
0
15
58
2.67
2.92
1.6
1.5
—
—
—
0
0
7
13
5.48
2.88
1.1
1.5
—
—
—
0
0
6
9
6.77
2.88
1.2
1.2
—
—
—
0
0
93
678
1.53
2.84
1.4
1.3
0.95
2.08
u/ml
1.00
24
209
6
10
6.09
2.71
1.2
1.5
—
—
—
0
0
6
10
6.09
2.71
1.2
1.5
—
—
—
0
0
8
19
4.29
2.69
1.4
1.6
—
—
—
0
0
9
24
3.83
2.69
1.6
1.3
—
—
—
0
0
77
545
1.55
2.68
1.4
1.3
41.96
31.30
iu/ml
0.45
31
183
11
35
3.22
2.67
1.3
1.0
—
—
—
0
0
37
216
1.81
2.67
3.8
2.4
62.75
69.83
ml/min/173m2
0.77
24
90
79
563
1.54
2.66
1.6
1.4
19.52
22.23
nmol/l
0.92
70
467
7
15
4.75
2.61
2.0
3.5
—
—
—
0
0
17
75
2.34
2.56
1.5
1.4
387.82
314.45
ug/g
1.06
11
40
6
11
5.54
2.55
1.2
1.5
—
—
—
0
0
6
11
5.54
2.55
1.2
1.5
—
—
—
0
0
10
31
3.30
2.54
1.5
1.1
—
—
—
0
0
11
37
3.04
2.51
1.3
1.5
—
—
—
0
0
11
37
3.04
2.51
1.3
1.5
—
—
—
0
0
11
38
2.96
2.44
1.3
1.5
—
—
—
0
0
12
46
2.67
2.38
1.3
1.2
—
—
—
0
0
12
46
2.67
2.38
1.3
1.2
—
—
—
0
0
6
13
4.68
2.28
1.5
1.9
—
—
—
0
0
6
13
4.68
2.28
2.0
1.7
—
—
—
0
0
6
13
4.68
2.28
1.2
1.5
—
—
—
0
0
6
13
4.68
2.28
1.5
1.9
—
—
—
0
0
6
13
4.68
2.28
1.2
1.5
—
—
—
0
0
7
18
3.95
2.26
1.1
1.4
—
—
—
0
0
7
19
3.74
2.16
1.4
2.0
—
—
—
0
0
7
19
3.74
2.16
1.4
2.0
—
—
—
0
0
7
19
3.74
2.16
1.4
2.0
—
—
—
0
0
5
10
5.06
2.08
5.6
4.7
188.00
215.90
u/l
—
5
10
294
2796
1.85
1.86
34.4
13.8
80.61
70.59
umol/l
2.03
294
2796
14
66
2.17
1.85
1.3
1.4
—
—
—
0
0
6
17
3.58
1.84
1.0
1.2
71.17
107.03
iu/ml
—
6
17
5
12
4.22
1.83
1.0
1.0
—
—
—
0
0
271
2533
1.52
1.76
5.6
5.0
1.98
2.29
mu/l
0.28
260
2351
6
18
3.38
1.75
3.0
3.8
—
—
—
0
0
9
36
2.54
1.75
1.3
1.0
—
—
—
0
0
5
13
3.89
1.72
1.6
1.5
13.91
31.82
ug/l
—
5
13
18
97
1.91
1.70
2.1
1.5
—
—
—
0
0
5
14
3.61
1.62
1.4
1.1
—
—
—
0
0
6
20
3.04
1.59
1.2
1.5
96.00
64.45
umol/l
—
6
20
5
15
3.37
1.53
1.0
1.3
1.70
1.55
g/l
—
5
15
70
543
1.37
1.48
1.3
1.3
22.51
10.77
u/ml
0.57
30
215
294
2818
1.71
1.48
25.9
9.3
25.02
23.97
u/l
0.65
294
2719
11
52
2.16
1.46
1.0
1.1
—
—
—
0
0
7
28
2.53
1.46
1.1
1.0
—
—
—
0
0
198
1781
1.30
1.46
3.7
2.9
55.41
40.69
u/l
1.01
189
1686
5
18
2.81
1.29
1.0
1.4
1.02
0.99
g/l
—
5
18
18
107
1.72
1.29
1.1
1.4
143.00
268.15
miu/ml
—
8
53
5
115
0.43
1.28
3.0
1.8
—
—
—
0
0
35
247
1.47
1.26
4.6
3.4
—
—
—
0
0
5
19
2.66
1.22
1.0
1.3
—
—
—
0
0
252
2369
1.33
1.18
5.4
5.1
37.89
38.94
mmol/mol
1.41
241
2218
203
1860
1.26
1.15
3.7
3.3
—
—
—
0
0
27
185
1.50
1.13
1.5
1.2
42.19
146.24
u/ml
3.29
22
168
5
21
2.40
1.09
1.0
1.1
—
—
—
0
0
7
33
2.15
1.06
2.4
1.8
574.20
117.51
u/ml
—
7
33
28
197
1.46
1.04
2.9
3.7
4.17
4.63
pmol/l
1.28
23
175
261
2480
1.32
1.02
4.3
3.7
1.32
1.25
mmol/l
0.79
247
2295
19
124
1.57
0.99
13.4
4.7
25.81
25.30
mmol/l
0.27
19
124
6
27
2.25
0.94
1.8
1.1
—
—
—
0
0
14
86
1.66
0.92
1.2
1.1
—
—
—
0
0
14
86
1.66
0.92
1.2
1.1
—
—
—
0
0
6
28
2.16
0.92
1.8
1.2
—
—
—
0
0
61
499
1.28
0.91
1.5
1.7
407.74
28941626.54
pmol/l
0.78
54
425
32
238
1.38
0.90
3.5
4.0
6.38
6.72
ug/l
0.04
23
196
6
109
0.54
0.73
1.7
1.5
—
—
—
0
0
5
27
1.87
0.68
1.8
1.9
6.78
8.00
mmol/l
—
5
27
20
270
0.72
0.68
1.3
1.7
—
—
—
0
0
80
698
1.20
0.67
1.9
1.6
1.42
1.39
mmol/l
0.10
73
594
5
28
1.80
0.66
1.0
1.3
—
—
—
0
0
30
235
1.31
0.64
14.3
6.3
0.69
1.37
mmol/l
0.50
23
194
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
12
170
0.69
0.55
1.5
1.5
—
—
—
0
0
267
2592
1.20
0.53
4.8
4.2
4.49
4.82
mmol/l
6.82
256
2421
266
2582
1.20
0.52
4.8
4.1
1.49
1.55
mmol/l
1.44
254
2401
10
145
0.68
0.52
1.2
1.4
—
—
—
0
0
20
155
1.31
0.48
1.1
1.0
—
—
—
0
0
270
2629
1.20
0.48
5.1
4.6
2.56
2.84
mmol/l
7.19
259
2442
7
51
1.38
0.44
1.1
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
7
57
1.23
0.29
1.3
1.6
—
—
—
0
0
25
218
1.16
0.24
2.0
2.8
44.62
40.54
u/ml
0.08
25
207
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
18.43
—
0
12
0
12
0.00
0.21
0.0
2.7
—
—
—
0
0
0
12
0.00
0.21
0.0
2.7
—
—
—
0
0
10
80
1.26
0.20
1.2
1.3
—
—
—
0
0
20
175
1.15
0.19
2.1
1.6
—
—
—
0
0
256
2525
1.08
0.16
4.7
4.1
5.39
5.77
mmol/l
7.84
243
2333
8
69
1.16
0.16
1.6
1.8
—
—
—
0
0
33
358
0.91
0.15
1.5
1.8
—
—
—
0
0
297
2949
1.14
0.14
45.7
18.0
37.86
39.88
%
4.69
288
2800
69
659
1.06
0.13
1.8
1.5
—
—
—
0
0
37
395
0.93
0.12
1.5
2.0
—
—
—
0
0
15
133
1.13
0.12
1.5
2.3
9790.26
4083.62
u/l
—
7
52
58
605
0.95
0.10
1.5
1.6
—
—
—
0
0
5
47
1.06
0.09
1.4
1.1
—
1.67
—
0
27
8
76
1.05
0.07
2.6
2.1
6.52
12.52
nmol/l
—
8
69
10
110
0.91
0.05
1.0
1.9
—
—
—
0
0
15
158
0.95
0.02
2.5
4.7
20.61
21.66
%
—
7
67
29
298
0.97
0.02
8.7
5.6
—
—
—
0
0
24
233
1.03
0.01
2.3
1.7
—
—
—
0
0
14
138
1.02
0.00
1.6
1.5
—
—
—
0
0
18
175
1.03
0.00
1.4
1.3
—
—
—
0
0
26
256
1.02
0.00
1.2
1.3
106.86
178.73
iu/ml
—
9
118
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
-0.00
1.3
1.5
—
—
—
0
0
7
75
0.93
-0.00
2.4
4.0
3.74
3.91
mmol/l
—
7
75
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
1.19
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint SLE_OTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SLE_OTH | 2.654 [2.26, 3.11] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.168 |
During the follow-up period (1.1.1998 — 31.12.2019), 283 out of 1188 females with SLE_OTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SLE_OTH | 2.679 [1.67, 4.29] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 186 males with SLE_OTH died.
Mortality risk
Mortality risk for people of age
years, who have SLE_OTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.202% | 0.566% |
| 5 | 1.436% | 2.969% |
| 10 | 3.668% | 7.89% |
| 15 | 7.028% | 14.305% |
| 20 | 12.148% | 23.574% |
Relationships between endpoints
↥Index endpoint: SLE_OTH – Other forms of systemic lupus erythematosus
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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