No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
303 |
4. Check minimum number of eventsNone |
303 |
5. Include endpointsNone |
303 |
6. Filter based on genotype QC (FinnGen only) |
303 |
Control definitions (FinnGen only)
- Control exclude
- SLE_FG
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M32
- Name in latin
- Aliae formae lupi erythematosi disseminati (LED)
Similar endpoints
↥List of similar endpoints to
Other forms of systemic lupus erythematosus
based on the number of shared cases.
Similar with more cases:
- SLE, strict definition
- SLE, ICD10
- Systemic lupus erythematosus
- SLE (Finngen)
- Systemic connective tissue disorders
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1584 | 1344 | 221 |
| Only index persons | 1393 | 1210 | 183 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.01 |
| Only index persons | 0.04 | 0.04 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 48.85 | 48.53 | 50.99 |
| Only index persons | 47.72 | 47.64 | 48.24 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 303 | 265 | 38 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.02 |
| Median age at first event (years) | 45.16 | 44.20 | 51.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 276
- Matched controls
- 2759
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
323.0
270
*
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
+∞
288.8
224
*
P01BA02
ATC
hydroxychloroquine; oral
111.6
205.4
233
127
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
60.8
170.5
225
186
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
99.1
89
*
L04AX01
ATC
azathioprine; systemic
35.5
92.3
122
60
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
90.7
82
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
79.0
72
*
M32
ICD-10 Finland
Systemic lupus erythematosus
+∞
56.2
52
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
14.4
55.8
102
108
L04AA06
ATC
mycophenolic acid; systemic
42.5
54.9
68
21
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
11.2
51.0
107
147
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.0
48.8
189
656
H02AB06
ATC
prednisolone; systemic
7.7
48.7
223
971
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
68.2
48.6
55
10
H02AB07
ATC
prednisone; oral
8.0
44.6
120
243
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
502.8
44.5
43
*
M05BA04
ATC
alendronic acid; oral
9.9
39.4
86
120
L93.0
ICD-10 Finland
Discoid lupus erythematosus
212.6
36.7
37
*
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
35.2
33
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
8.2
32.8
80
131
R50.9
ICD-10 Finland
Fever, unspecified
6.5
29.5
86
179
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.3
28.9
76
137
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
7.2
26.2
68
119
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
10.7
25.7
51
57
M35.1
ICD-10 Finland
Other overlap syndromes
59.5
23.5
27
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.7
23.4
159
742
H02AB04
ATC
methylprednisolone; systemic
4.8
23.2
89
248
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
8.4
22.4
51
72
C08CA05
ATC
nifedipine; systemic
7.7
21.4
52
81
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
14.1
21.1
36
29
L88
ICPC
Rheumatoid/seropositive arthritis
9.8
20.8
43
51
L04AA01
ATC
[U] ciclosporin; systemic
20.6
19.1
28
15
ZX120
NOMESCO Finland
Intravenous
5.4
18.0
58
130
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.7
17.9
66
172
B01AA03
ATC
warfarin; systemic
4.3
17.6
73
213
G73.7*M32.1
ICD-10 Finland
Myopathy in systemic lupus erythematosus
+∞
16.8
16
*
D68.8
ICD-10 Finland
Other specified coagulation defects
28.2
15.8
21
8
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
15.8
15
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.6
15.7
82
288
P01BA01
ATC
chloroquine; systemic
40.6
15.6
19
5
J99.1*M32.1
ICD-10 Finland
Respiratory disorders in systemic: lupus erythematosus
+∞
14.7
14
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
38.3
14.6
18
5
XX9XE
NOMESCO Finland
Other ultrasound examination
18.3
14.6
22
13
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.8
14.3
66
209
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.8
14.0
49
119
TPH04
NOMESCO Finland
Cathetrisation of vein
3.3
14.0
82
311
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.5
14.0
75
268
A02BC01
ATC
omeprazole; systemic
3.0
13.8
101
448
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
13.7
105
478
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.6
13.2
146
827
G05.8*M32.1
ICD-10 Finland
Encephalitis in systemic lupus erythematosus
+∞
12.6
12
*
F02.89*M32.8
ICD-10 Finland
Dementia in systemic lupus erythematosus
+∞
12.6
12
*
N02AX02
ATC
tramadol; systemic, rectal
2.6
12.6
137
761
J05AB11
ATC
valaciclovir; oral
3.4
12.5
67
237
L04AD01
ATC
ciclosporin; systemic
11.3
12.0
22
21
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
7.5
12.0
28
41
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.8
11.9
54
167
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
17.4
11.8
18
11
R06.0
ICD-10 Finland
Dyspnoea
2.8
11.8
91
411
J05AB01
ATC
aciclovir; systemic
2.8
11.8
89
398
B02.9
ICD-10 Finland
Zoster without complication
5.8
11.6
33
63
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.1
11.6
37
81
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.3
11.6
44
116
C03CA01
ATC
furosemide; systemic
2.9
11.5
83
360
J01MA12
ATC
levofloxacin; systemic
3.1
11.5
70
270
M05BA07
ATC
risedronic acid; oral
6.8
11.3
28
45
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
14.7
11.1
18
13
R4120
NOMESCO Finland
Occupational therapy
5.1
11.1
35
76
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
6.5
10.9
28
47
B01AB05
ATC
enoxaparin; parenteral
2.5
10.7
102
516
73491
ICD-8 Finland
Diffuse diseases of connective tissue, Collagenosis NUD
+∞
10.5
10
*
1XC02
NOMESCO Finland
NA
33.9
10.4
13
*
D07AB08
ATC
desonide; topical
3.4
10.4
54
186
B07.9
ICD-10 Finland
Verruca simplex
6.6
10.3
26
43
E0000UV
ATC
NA
2.3
10.3
139
839
J01FF01
ATC
clindamycin; systemic
2.5
10.1
104
543
J01FA06
ATC
roxithromycin; oral
2.3
9.9
137
829
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
9.9
74
323
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.9
9.5
26
48
L01BB01
ATC
NA
+∞
9.4
9
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.5
9.4
46
151
A02BC02
ATC
pantoprazole; systemic
2.3
9.4
195
1413
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.4
9.1
33
83
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
9.0
49
171
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.3
9.0
33
84
L01AA01
ATC
cyclophosphamide; systemic
51.6
8.7
10
*
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
51.6
8.7
10
*
M05BB03
ATC
alendronic acid and colecalciferol; oral
7.3
8.7
20
29
B99
ICD-10 Finland
Other and unspecified infectious diseases
12.1
8.7
15
13
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
12.1
8.7
15
13
N32.9
ICD-10 Finland
Bladder disorder, unspecified
28.5
8.5
11
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.0
8.5
34
94
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.6
8.5
24
46
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
7.5
8.4
19
27
7108X
ICD-9 Finland
Diffuse diseases of connective tissue, Other specified diffuse diseases of connective tissue
+∞
8.4
8
*
E000001
ATC
NA
2.5
8.3
77
376
A02BC03
ATC
lansoprazole; oral
2.3
8.3
97
529
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.6
8.2
63
278
D07AC01
ATC
betamethasone; topical
2.2
8.1
110
642
A02BC05
ATC
esomeprazole; systemic
2.1
8.1
126
784
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
8.9
7.9
16
19
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
7.3
7.9
18
26
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
11.3
7.9
14
13
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
7.8
7.8
17
23
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
6.5
7.7
19
31
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.0
7.7
140
923
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.4
7.6
36
116
XPX04
NOMESCO Finland
Angioscopy
82.2
7.5
8
*
L93.1
ICD-10 Finland
Subacute cutaneous lupus erythematosus
+∞
7.3
7
*
69540
ICD-8 Finland
Erythematous condition, Lupus erythematosus
+∞
7.3
7
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.3
7.3
37
125
J01MA14
ATC
moxifloxacin; systemic
3.2
7.3
38
131
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.8
7.3
23
51
S01AX11
ATC
[U] ofloxacin; ophthalmic
6.9
7.2
17
26
A41.9
ICD-10 Finland
Sepsis, unspecified
5.9
7.2
19
34
M05BA01
ATC
etidronic acid; systemic
30.9
7.2
9
*
C08CA01
ATC
amlodipine; oral
2.2
7.1
88
489
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
7.1
75
386
J01MA02
ATC
ciprofloxacin; systemic
2.0
7.1
111
683
NF1AA
NOMESCO Finland
Hip X-ray examination
3.4
7.1
33
105
L04AA13
ATC
leflunomide; oral
5.7
7.1
19
35
Z50.1
ICD-10 Finland
Other physical therapy
4.1
7.0
26
68
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.4
7.0
33
106
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
7.0
60
280
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
4.8
6.9
22
49
H26.3
ICD-10 Finland
Drug-induced cataract
14.2
6.9
11
8
N02AA05
ATC
oxycodone; systemic
2.7
6.9
47
194
205
Kela drug reimbursment
Chronic hypertension
2.3
6.8
68
342
G73.7
ICD-10 Finland
Myopathy in other diseases classified elsewhere
41.1
6.8
8
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
4.1
6.8
25
65
L99
ICPC
Musculoskeletal disease other
6.2
6.7
17
29
D02BB01
ATC
betacarotene; oral
23.2
6.7
9
*
M05BX04
ATC
denosumab; parenteral
4.1
6.7
25
66
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.3
6.7
33
110
A07AA02
ATC
nystatin; oral
3.5
6.7
30
93
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.7
6.6
21
47
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.9
6.6
26
72
XCK00
NOMESCO Finland
Perimetry
3.6
6.6
28
83
C02CA01
ATC
prazosin; oral
14.7
6.4
10
7
J01DB01
ATC
cefalexin; oral
2.3
6.4
238
2007
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
3.9
6.4
25
69
R4110
NOMESCO Finland
Physiotherapy
2.1
6.3
85
487
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
18.5
6.3
9
5
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
6.3
6
*
6BA02
NOMESCO Finland
NA
27.3
6.3
8
*
UJF30
NOMESCO Finland
Ileoscopy through colon
2.9
6.2
37
140
H53.1
ICD-10 Finland
Subjective visual disturbances
3.4
6.2
29
93
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.7
6.2
42
171
B01AB04
ATC
dalteparin; parenteral
4.4
6.2
21
51
XF400
NOMESCO Finland
ECG with 12 standard connections
2.5
6.1
50
225
H26.2
ICD-10 Finland
Complicated cataract
12.9
6.1
10
8
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
5.4
6.1
17
33
N02AJ06
ATC
codeine and paracetamol; systemic
1.9
6.1
111
710
A46
ICD-10 Finland
Erysipelas
2.8
6.1
39
154
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
5.8
6.1
16
29
M01AH02
ATC
rofecoxib; oral
2.6
6.1
43
181
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.1
6.0
31
107
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
149
92
30.90
189.90
9.1
1.5
—
—
—
0
0
96
78
17.55
102.59
2.0
1.2
29.0
2.5
u/ml
—
36
9
95
80
16.84
99.30
2.0
1.2
21.6
2.9
u/ml
2.33
45
13
78
69
14.88
78.29
2.0
1.1
61.9
40.5
u/ml
—
25
7
55
47
14.08
55.65
1.4
1.2
10.2
6.7
u/ml
0.24
33
14
51
50
12.06
47.06
1.4
1.2
6.3
11.9
u/ml
0.43
36
17
255
1232
7.75
46.68
17.9
5.1
26.3
29.0
%
3.49
250
1141
270
1472
8.66
40.26
19.9
8.5
3.9
3.9
e9/l
0.24
260
1297
31
21
16.33
35.29
1.5
1.1
—
—
—
0
0
31
21
16.33
35.29
1.5
1.1
—
—
—
0
0
31
22
15.58
34.42
1.5
1.1
—
—
—
0
0
31
22
15.58
34.42
1.5
1.1
—
—
—
0
0
31
22
15.58
34.42
1.5
1.1
—
—
—
0
0
212
1102
4.08
29.12
3.7
2.3
81.9
77.3
nmol/l
1.53
205
986
176
847
3.57
26.36
7.1
2.9
—
—
—
0
0
191
984
3.55
25.31
6.7
4.0
34.2
36.4
g/l
6.20
181
922
147
648
3.46
25.04
5.9
2.8
0.2
0.4
e6/l
1.20
125
481
222
1290
3.70
23.58
7.8
3.5
0.0
0.0
estimate
0.00
45
247
219
1270
3.61
23.15
7.7
3.5
0.0
0.0
estimate
0.00
43
252
219
1277
3.58
22.79
11.2
4.8
0.0
0.0
estimate
0.50
45
254
23
20
12.36
22.49
1.1
1.2
—
—
—
0
0
205
1166
3.34
21.86
12.2
5.8
1.2
1.2
mmol/l
0.01
182
975
148
706
3.14
21.28
2.5
2.0
95.3
259.9
u/l
1.08
142
664
83
297
3.47
19.01
4.1
2.3
19.0
22.7
%
1.97
76
253
20
19
11.20
18.41
1.5
1.1
1.1
1.1
ratio
—
6
6
91
370
3.09
16.65
5.0
2.5
1.9
1.1
e6/l
0.69
66
194
58
180
3.75
16.32
5.7
3.6
2.0
2.1
mmol/l
0.10
48
146
117
558
2.79
15.86
3.1
3.1
1382.4
953.4
ng/l
0.60
105
470
55
169
3.75
15.67
2.0
3.0
65.8
67.2
g/l
0.62
50
150
85
350
2.99
15.05
5.4
2.7
2.4
4.0
e6/l
1.20
61
175
23
35
7.03
14.69
2.5
3.4
1.5
1.7
%
0.08
16
25
117
582
2.65
14.34
3.1
2.0
3.1
3.0
mg/l
0.22
110
495
81
334
2.95
14.23
2.1
1.8
—
—
—
0
0
16
18
9.33
13.00
1.5
2.2
—
—
—
0
0
18
9
21.16
12.61
2.5
2.3
—
—
—
0
0
48
156
3.47
12.47
1.6
1.7
—
—
—
0
0
43
130
3.69
12.45
5.7
3.0
0.1
0.2
e6/l
0.54
43
124
30
72
4.51
11.83
1.9
2.5
7.1
7.6
g/l
0.63
24
58
30
72
4.51
11.83
1.9
2.5
—
—
—
0
0
30
72
4.51
11.83
1.9
2.5
3.0
3.7
g/l
3.08
23
55
64
259
2.86
11.45
40.0
16.6
1.3
1.2
inr
0.11
16
41
24
49
5.23
11.41
1.7
1.3
—
—
—
0
0
167
1056
2.30
11.33
10.5
5.2
1.2
1.2
mmol/l
0.54
161
955
77
345
2.65
11.31
4.8
3.1
0.8
0.8
mmol/l
0.21
71
325
28
69
4.37
10.67
2.0
2.6
3.0
3.2
g/l
0.59
23
56
24
54
4.74
10.21
1.5
1.6
—
—
—
0
0
60
249
2.76
10.17
1.9
1.9
353.2
380.9
nmol/l
0.50
54
233
13
17
7.95
9.34
1.5
2.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
50
4.67
9.24
2.8
2.5
0.3
0.3
u/ml
0.01
14
27
20
44
4.80
8.72
1.1
1.3
—
—
—
0
0
112
654
2.13
8.69
6.4
3.8
25.7
7.8
mg/mmol
1.15
87
385
153
1007
2.05
8.57
8.3
3.6
—
—
—
0
0
53
225
2.64
8.53
2.1
1.8
—
—
—
0
0
101
572
2.15
8.44
2.1
1.7
1.6
0.9
mg/l
1.28
82
442
29
88
3.54
8.30
5.7
3.5
23.7
24.2
mmol/l
0.30
24
82
18
38
4.97
8.22
1.2
1.6
—
—
—
0
0
26
74
3.75
8.17
1.7
1.6
0.2
0.0
iu/ml
—
6
11
21
51
4.35
8.14
1.3
1.9
—
—
—
0
0
52
224
2.60
8.11
2.1
1.7
—
—
—
0
0
134
857
2.01
7.98
4.4
3.4
600.2
29.0
ng/l
0.52
94
538
21
52
4.26
7.94
1.4
1.6
—
—
—
0
0
29
91
3.42
7.89
1.9
2.0
—
—
—
0
0
173
1213
1.99
7.88
4.3
2.8
111.4
80.0
ug/l
1.48
165
1127
23
62
3.93
7.78
1.4
1.3
—
—
—
0
0
182
1307
1.98
7.65
7.2
5.5
9.4
9.8
umol/l
0.34
176
1230
27
83
3.47
7.58
2.1
1.9
—
—
—
0
0
20
52
4.05
7.10
6.5
3.9
59.7
57.8
%
0.26
20
52
26
82
3.37
7.02
1.3
1.4
—
—
—
0
0
19
51
3.91
6.47
6.7
3.5
3.5
4.5
e9/l
1.02
19
51
74
411
2.06
6.30
4.9
3.5
368.9
143.4
ng/l
0.79
54
292
13
26
5.18
6.28
1.1
1.0
—
—
—
0
0
14
30
4.84
6.28
1.1
1.6
—
—
—
0
0
16
39
4.28
6.17
1.3
1.6
—
—
—
0
0
184
1387
1.83
6.04
7.1
4.0
6.2
6.5
mmol/l
1.18
177
1273
13
27
4.99
6.03
1.1
1.7
—
—
—
0
0
126
854
1.81
5.83
3.7
3.2
2.3
2.4
mmol/l
2.21
117
756
15
37
4.21
5.69
1.3
1.2
—
—
—
0
0
18
52
3.62
5.54
3.5
2.4
—
—
—
0
0
12
25
4.96
5.54
1.3
1.4
—
—
—
0
0
14
34
4.27
5.42
1.2
1.6
—
—
—
0
0
17
48
3.69
5.40
1.2
1.5
373.1
265.1
u/ml
—
10
28
23
80
3.03
5.32
1.2
1.1
—
—
—
0
0
90
564
1.85
5.29
6.4
3.7
1.0
1.0
kg/l
0.04
14
78
286
2563
3.07
5.23
34.4
12.2
17.3
20.9
mg/l
1.74
256
1961
13
31
4.34
5.14
3.5
2.5
108.3
106.9
mmol/l
0.43
13
31
13
31
4.34
5.14
3.5
2.5
3.9
3.9
mmol/l
0.06
13
31
17
51
3.47
4.96
1.2
1.5
—
—
—
0
0
29
120
2.57
4.89
1.6
1.6
—
—
—
0
0
92
595
1.78
4.82
4.2
2.6
8840.7
8733.5
umol/l
0.00
83
517
66
385
1.91
4.80
1.9
1.7
1202.5
1284.3
nmol/l
0.29
54
282
35
160
2.34
4.78
1.7
2.4
8.5
5.1
ug/l
0.52
30
141
13
33
4.07
4.76
1.4
1.4
—
—
—
0
0
130
944
1.66
4.40
2.3
1.9
100.7
97.2
pmol/l
0.32
65
464
28
121
2.45
4.33
5.4
3.5
0.8
1.5
mmol/l
0.19
23
91
154
1175
1.63
4.24
4.9
3.9
—
—
—
0
0
88
584
1.71
4.14
2.7
2.1
—
—
—
0
0
7
7
10.20
4.03
2.9
2.1
49.4
153.4
ug/l
—
7
7
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
14
6.59
4.01
1.2
1.1
—
—
—
0
0
19
71
2.79
3.90
1.4
1.2
—
—
—
0
0
99
688
1.65
3.88
8.3
3.8
0.0
0.0
estimate
0.50
45
255
7
8
8.92
3.79
1.0
1.4
—
—
—
0
0
7
9
7.93
3.57
1.1
1.1
—
—
—
0
0
6
6
10.17
3.51
1.2
1.2
—
—
—
0
0
18
70
2.67
3.45
1.5
2.2
9.4
10.0
mg/l
0.18
18
64
27
128
2.22
3.42
1.8
1.3
—
—
—
0
0
10
27
3.80
3.38
1.5
1.1
—
—
—
0
0
13
43
3.11
3.29
1.3
1.3
—
—
—
0
0
14
49
2.95
3.23
1.4
1.4
—
111.0
—
0
12
9
20
4.60
3.13
1.2
1.7
12.9
11.7
umol/l
—
9
20
14
50
2.89
3.13
1.1
1.1
—
—
—
0
0
10
29
3.53
3.07
1.2
1.0
—
—
—
0
0
68
454
1.64
3.05
3.7
2.5
2.5
2.4
mmol/l
0.19
61
398
7
12
5.94
3.03
2.3
2.8
367.3
713.7
u/ml
—
7
12
37
207
1.90
3.03
3.8
2.5
62.7
69.3
ml/min/173m2
0.68
24
85
238
2099
1.62
3.01
4.6
4.3
14.6
14.5
pmol/l
0.25
228
1930
5
5
10.14
2.99
1.0
1.4
—
—
—
0
0
266
2419
1.82
2.95
25.5
11.1
83.6
84.6
ml/min/173m2
0.26
249
1950
8
17
4.80
2.94
1.3
1.0
—
—
—
0
0
12
41
3.01
2.89
1.8
1.4
—
—
—
0
0
7
13
5.48
2.88
1.1
1.5
—
—
—
0
0
6
9
6.77
2.88
1.2
1.2
—
—
—
0
0
7
14
5.09
2.74
2.0
4.0
—
—
—
0
0
11
37
3.05
2.72
1.3
1.5
—
—
—
0
0
11
37
3.05
2.72
1.3
1.5
—
—
—
0
0
11
37
3.05
2.72
1.3
1.5
—
—
—
0
0
6
10
6.09
2.71
1.3
2.5
—
—
—
0
0
6
10
6.09
2.71
1.3
2.5
—
—
—
0
0
8
19
4.29
2.69
1.4
1.6
—
—
—
0
0
9
24
3.83
2.69
1.6
1.3
—
—
—
0
0
10
32
3.20
2.67
1.3
1.0
—
—
—
0
0
90
664
1.51
2.59
1.4
1.3
1.0
2.1
u/ml
1.00
23
203
77
552
1.53
2.53
1.6
1.5
19.5
22.2
nmol/l
0.91
68
457
14
58
2.48
2.40
1.6
1.5
—
—
—
0
0
12
46
2.68
2.39
1.3
1.2
—
—
—
0
0
12
46
2.68
2.39
1.3
1.2
—
—
—
0
0
6
13
4.68
2.28
2.0
1.7
—
—
—
0
0
6
13
4.68
2.28
1.5
1.9
—
—
—
0
0
6
13
4.68
2.28
1.5
1.9
—
—
—
0
0
6
13
4.68
2.28
1.5
1.9
—
—
—
0
0
6
13
4.68
2.28
1.2
1.5
—
—
—
0
0
6
13
4.68
2.28
1.2
1.5
—
—
—
0
0
6
13
4.68
2.28
1.5
1.9
—
—
—
0
0
7
18
3.95
2.26
1.1
1.4
—
—
—
0
0
5
9
5.63
2.22
5.6
4.1
188.0
207.3
u/l
—
5
9
16
74
2.23
2.19
1.6
1.4
387.8
316.7
ug/g
1.00
11
39
7
19
3.75
2.16
1.4
2.0
—
—
—
0
0
7
19
3.75
2.16
1.4
2.0
—
—
—
0
0
7
19
3.75
2.16
1.4
2.0
—
—
—
0
0
5
10
5.06
2.08
1.2
1.5
—
—
—
0
0
5
10
5.06
2.08
1.2
1.5
—
—
—
0
0
5
11
4.60
1.95
1.2
1.5
—
—
—
0
0
5
11
4.60
1.95
1.2
1.5
—
—
—
0
0
6
18
3.38
1.75
3.0
3.8
—
—
—
0
0
5
13
3.89
1.72
1.4
1.2
—
—
—
0
0
5
13
3.89
1.72
1.6
1.5
13.9
31.8
ug/l
—
5
13
70
532
1.41
1.68
1.4
1.3
42.1
31.7
iu/ml
0.40
28
178
284
2708
1.78
1.65
34.8
13.8
81.0
70.6
umol/l
2.04
284
2708
7
26
2.73
1.59
1.1
1.0
—
—
—
0
0
8
33
2.46
1.55
1.4
1.0
—
—
—
0
0
9
37
2.48
1.49
1.3
1.5
—
—
—
0
0
9
37
2.48
1.49
1.3
1.5
—
—
—
0
0
9
38
2.41
1.47
1.3
1.5
—
—
—
0
0
17
96
1.82
1.42
2.2
1.5
—
—
—
0
0
5
17
2.97
1.36
1.0
1.2
81.4
107.0
iu/ml
—
5
17
192
1737
1.29
1.31
3.7
2.9
56.0
41.0
u/l
1.00
184
1643
5
18
2.81
1.29
1.0
1.4
1.0
1.0
g/l
—
5
18
284
2730
1.64
1.29
26.4
9.4
25.0
23.9
u/l
0.67
284
2635
34
239
1.48
1.25
4.7
3.3
—
—
—
0
0
5
19
2.66
1.22
1.0
1.3
—
—
—
0
0
5
19
2.66
1.22
1.0
1.1
—
—
—
0
0
28
191
1.51
1.19
2.9
3.8
4.2
4.7
pmol/l
1.37
23
169
27
183
1.52
1.18
1.5
1.2
42.2
147.1
u/ml
3.31
22
167
10
50
2.03
1.18
1.0
1.1
—
—
—
0
0
61
483
1.33
1.14
1.5
1.7
407.7
29927457.3
pmol/l
0.78
54
411
197
1804
1.26
1.14
3.8
3.3
—
—
—
0
0
11
58
1.93
1.13
2.4
2.3
7.9
8.1
kpa
0.15
11
52
258
2447
1.37
1.13
5.7
5.0
2.0
2.3
mu/l
0.30
247
2272
12
66
1.85
1.10
1.3
1.4
—
—
—
0
0
17
105
1.66
1.08
1.1
1.4
162.7
268.1
miu/ml
—
7
53
243
2291
1.31
1.06
5.5
5.1
37.9
38.9
mmol/mol
1.30
233
2146
14
83
1.72
1.03
1.2
1.1
—
—
—
0
0
14
83
1.72
1.03
1.2
1.1
—
—
—
0
0
253
2404
1.32
1.00
4.3
3.7
1.3
1.2
mmol/l
0.75
239
2224
5
105
0.47
0.90
3.0
1.8
—
—
—
0
0
64
529
1.27
0.88
1.3
1.3
24.1
11.0
u/ml
0.60
28
211
26
188
1.42
0.86
1.7
1.3
—
38.5
—
0
10
18
121
1.52
0.85
14.0
4.6
26.0
25.3
mmol/l
0.38
18
121
31
233
1.37
0.83
3.5
4.0
6.4
6.8
ug/l
0.05
23
191
38
298
1.31
0.79
4.2
4.0
32.9
32.4
%
0.14
33
194
6
107
0.55
0.74
1.7
1.5
—
—
—
0
0
5
25
2.02
0.73
1.8
1.8
6.8
7.3
mmol/l
—
5
16
78
674
1.21
0.73
1.9
1.6
1.4
1.4
mmol/l
0.05
71
572
9
143
0.62
0.71
1.2
1.4
—
—
—
0
0
5
27
1.87
0.68
2.0
1.1
—
—
—
0
0
29
224
1.33
0.68
14.7
5.7
0.7
1.3
mmol/l
0.42
22
181
260
2510
1.25
0.66
4.9
4.2
4.5
4.8
mmol/l
6.39
249
2342
5
28
1.80
0.66
2.0
1.2
—
—
—
0
0
5
28
1.80
0.66
1.0
1.4
—
—
—
0
0
259
2500
1.25
0.66
4.8
4.1
1.5
1.6
mmol/l
1.59
247
2323
263
2546
1.25
0.62
5.1
4.6
2.6
2.8
mmol/l
6.55
252
2362
20
265
0.74
0.61
1.3
1.7
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
20
154
1.32
0.50
1.1
1.0
—
—
—
0
0
7
51
1.38
0.44
1.1
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
13
167
0.77
0.35
1.5
1.5
—
—
—
0
0
25
210
1.21
0.34
2.0
2.8
44.6
41.6
u/ml
0.06
25
199
7
56
1.26
0.29
1.3
1.5
—
—
—
0
0
8
67
1.20
0.26
1.6
1.8
—
—
—
0
0
10
77
1.31
0.26
1.2
1.3
—
—
—
0
0
20
171
1.18
0.24
2.1
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
17.3
—
0
10
0
12
0.00
0.21
0.0
2.7
—
—
—
0
0
0
12
0.00
0.21
0.0
2.7
—
—
—
0
0
15
129
1.17
0.17
1.5
2.2
9790.3
4163.2
u/l
—
7
51
248
2449
1.07
0.14
4.8
4.1
5.4
5.8
mmol/l
7.47
235
2266
56
587
0.94
0.12
1.6
1.6
—
—
—
0
0
66
635
1.05
0.10
1.8
1.5
—
—
—
0
0
5
46
1.09
0.09
1.4
1.1
—
1.7
—
0
26
33
347
0.95
0.07
1.5
1.9
—
—
—
0
0
8
74
1.08
0.07
2.6
2.2
6.5
12.5
nmol/l
—
8
67
24
227
1.06
0.06
2.3
1.7
—
—
—
0
0
239
2373
1.03
0.06
31.3
12.7
36.6
39.8
%
4.16
183
1821
37
384
0.96
0.05
1.5
2.0
—
—
—
0
0
26
249
1.05
0.04
1.2
1.3
106.9
180.8
iu/ml
—
9
115
10
109
0.91
0.04
1.0
1.9
—
—
—
0
0
15
158
0.95
0.02
2.5
4.7
20.6
21.7
%
—
7
67
28
287
0.97
0.01
8.7
5.5
—
—
—
0
0
17
166
1.03
0.00
1.4
1.3
—
—
—
0
0
14
136
1.03
0.00
1.6
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
1.2
—
0
5
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
0.00
1.3
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint SLE_OTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SLE_OTH | 2.654 [2.26, 3.11] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.168 |
During the follow-up period (1.1.1998 — 31.12.2019), 283 out of 1188 females with SLE_OTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SLE_OTH | 2.679 [1.67, 4.29] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 186 males with SLE_OTH died.
Mortality risk
Mortality risk for people of age
years, who have SLE_OTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.202% | 0.566% |
| 5 | 1.436% | 2.969% |
| 10 | 3.668% | 7.89% |
| 15 | 7.028% | 14.305% |
| 20 | 12.148% | 23.574% |
Relationships between endpoints
↥Index endpoint: SLE_OTH – Other forms of systemic lupus erythematosus
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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