Scarlet fever

AB1_SCARLET_FEVER

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A38
  • Hospital discharge: ICD-9 03[4]
  • Hospital discharge: ICD-8 03[4]
  • Hospital discharge: excluded ICD-9 034[0]
  • Hospital discharge: excluded ICD-8 034[0]
  • Cause of death: ICD-10 A38
  • Cause of death: ICD-9 03[4]
  • Cause of death: ICD-8 03[4]
  • Cause of death: excluded ICD-9 034[0]
  • Cause of death: excluded ICD-8 034[0]

2 out of 7 registries used, show all original rules.

264

4. Check minimum number of events

None

264

5. Include endpoints

None

264

6. Filter based on genotype QC (FinnGen only)

258

Control definitions (FinnGen only)

Control exclude
AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4075 1777 2286
Only index persons 3185 1380 1805
Unadjusted period prevalence (%)
Whole population 0.06 0.05 0.06
Only index persons 0.06 0.05 0.07
Median age at first event (years)
Whole population 7.01 6.65 7.16
Only index persons 7.59 7.19 7.90

-FinnGen-

Key figures

All Female Male
Number of individuals 258 144 114
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 10.52 9.03 12.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
264
Matched controls
2640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
03419
ICD-8 Finland
Streptococcal sore throat and scarlet fever, Scarlatina NUD
+∞
98.2
88
*
A38
ICD-10 Finland
Scarlet fever
+∞
89.8
81
*
03417
ICD-8 Finland
Streptococcal sore throat and scarlet fever, Scarlatina suspecta
+∞
46.2
43
*
0341A
ICD-9 Finland
Streptococcal sore throat and scarlatina, Scarlatina[SCARLATINA STREPTOCOCCUS BETAHAEMOLYTICUS,RYHMÄ-A]
+∞
16.8
16
*
0341X
ICD-9 Finland
Streptococcal sore throat and scarlatina, Scarlatina[SCARLATINA STREPTOCOCCUS BETAHAEMOLYTICUS,MUU]
+∞
15.8
15
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
27.4
13.6
18
7
A46
ICD-10 Finland
Erysipelas
5.6
11.3
22
42
03410
ICD-8 Finland
Streptococcal sore throat and scarlet fever, Scarlatina cum complicatione
+∞
8.4
8
*
A41.9
ICD-10 Finland
Sepsis, unspecified
+∞
7.3
7
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.1
6.0
25
85

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
60
297
2.32
6.98
4.3
3.1
—
—
—
0
0
179
1412
1.83
4.95
8.4
6.0
77.83
75.76
u/l
0.27
169
1335
94
621
1.80
4.71
8.8
7.1
1.09
1.12
inr
0.27
40
209
34
156
2.35
4.64
4.7
2.7
—
—
—
0
0
126
913
1.73
4.54
13.6
7.2
0.00
0.00
e9/l
0.80
106
744
120
859
1.73
4.51
7.2
4.9
10.43
11.32
umol/l
0.42
111
826
93
625
1.75
4.34
8.0
3.8
36.77
37.62
g/l
0.84
83
601
14
36
4.05
4.06
1.9
3.4
54.93
54.44
%
0.06
14
36
14
36
4.05
4.06
1.9
3.3
3.79
3.69
e9/l
0.07
14
36
38
199
2.06
3.77
1.7
1.8
—
—
—
0
0
50
293
1.87
3.60
1.5
1.4
146.67
603.81
titre
4.30
12
63
36
192
2.01
3.41
1.5
1.4
—
—
—
0
0
37
200
1.99
3.37
1.8
1.4
—
—
—
0
0
11
28
4.05
3.33
3.1
1.8
17.76
17.26
%
—
5
16
95
682
1.61
3.30
14.1
4.7
1.21
1.22
mmol/l
1.33
85
636
69
463
1.66
3.11
1.5
1.7
—
—
—
0
0
175
1462
1.58
3.08
5.2
3.5
8.30
8.20
mm/h
0.05
161
1380
75
524
1.60
2.86
2.1
2.3
52.77
58.55
u/l
0.77
64
498
43
262
1.77
2.73
1.8
1.6
425.53
27572457.47
pmol/l
0.50
36
243
127
1012
1.49
2.62
5.5
3.6
6.59
6.34
mmol/l
0.48
115
925
55
364
1.65
2.59
3.4
2.0
2.74
2.73
mg/l
0.02
49
313
70
492
1.58
2.58
5.2
2.9
0.00
0.01
estimate
0.50
27
178
120
952
1.48
2.50
9.3
5.7
—
—
—
0
0
21
103
2.13
2.49
1.2
1.3
—
—
—
0
0
31
177
1.85
2.43
4.8
1.7
2.57
2.53
g/l
0.15
31
167
48
313
1.65
2.39
3.9
2.0
471.45
552.05
mosm/kgh2o
1.28
42
255
76
553
1.53
2.39
2.9
2.8
20.40
23.62
ng/l
0.16
42
273
183
1593
1.48
2.27
4.6
3.8
14.64
14.45
pmol/l
0.47
168
1490
9
29
3.18
2.24
8.1
1.3
8.88
9.54
kpa
—
9
29
9
29
3.18
2.24
8.1
1.3
4.69
4.93
kpa
—
9
29
5
9
5.64
2.22
5.2
2.1
—
—
—
0
0
8
24
3.40
2.20
1.6
1.4
—
—
—
0
0
71
519
1.50
2.17
4.2
2.6
2.34
2.36
mmol/l
0.56
63
471
31
184
1.78
2.16
2.2
1.6
1452.38
1117.00
nmol/l
1.37
26
148
17
82
2.15
2.12
3.6
2.9
64.54
69.40
e9/l
0.14
12
55
97
759
1.44
2.09
14.3
5.2
1.21
1.22
mmol/l
0.96
78
651
24
133
1.88
2.07
4.0
4.6
0.00
0.23
%
—
8
31
25
141
1.85
2.05
3.8
4.4
0.25
0.08
%
—
8
38
57
402
1.53
2.05
1.9
1.8
0.70
0.91
mg/l
0.41
41
291
24
135
1.86
1.99
3.9
4.2
0.29
0.32
%
—
7
37
60
431
1.51
1.98
2.7
2.3
5481.47
1350.69
umol/l
0.36
51
400
7
21
3.39
1.98
1.9
1.3
—
—
—
0
0
62
449
1.50
1.97
4.5
3.0
7.39
7.40
ph
0.53
21
82
5
11
4.61
1.95
1.6
1.1
—
—
—
0
0
126
1046
1.39
1.90
9.0
5.7
0.19
0.19
e9/l
0.11
115
931
127
1056
1.39
1.89
8.7
5.4
1.98
2.05
e9/l
0.45
117
948
150
1286
1.39
1.84
3.3
2.9
—
—
—
0
0
25
147
1.77
1.81
3.8
4.3
1.62
0.48
%
—
8
44
76
582
1.43
1.81
1.8
2.1
—
—
—
0
0
122
1016
1.37
1.77
8.8
5.4
0.55
0.55
e9/l
0.04
112
893
12
54
2.28
1.76
1.0
1.9
—
—
—
0
0
122
1017
1.37
1.75
8.9
5.5
0.04
0.04
e9/l
0.47
112
894
8
30
2.72
1.74
8.9
1.7
—
—
—
0
0
221
2039
1.51
1.71
16.2
8.6
139.41
139.76
mmol/l
1.90
214
1989
68
515
1.43
1.71
2.7
1.8
—
—
—
0
0
57
418
1.46
1.70
2.8
2.1
—
—
—
0
0
7
25
2.85
1.66
5.3
2.6
—
—
—
0
0
59
439
1.44
1.63
5.3
2.3
0.13
0.28
e6/l
1.22
47
313
8
32
2.55
1.61
1.3
1.2
—
—
—
0
0
10
43
2.38
1.60
1.1
1.3
—
—
—
0
0
6
20
3.04
1.59
7.5
3.1
13.30
7.59
u/ml
—
6
20
22
130
1.76
1.59
3.3
2.4
14035.73
3695.39
u/l
0.36
12
53
29
187
1.62
1.53
1.3
1.6
—
—
—
0
0
59
445
1.42
1.51
5.2
2.3
—
—
—
0
0
21
125
1.74
1.48
24.5
3.3
7.43
7.41
ph
—
5
14
11
52
2.16
1.46
2.4
1.2
—
—
—
0
0
152
1336
1.32
1.44
6.4
3.3
—
—
—
0
0
5
16
3.16
1.44
1.6
2.2
—
—
—
0
0
9
40
2.29
1.41
5.0
1.9
—
—
—
0
0
9
40
2.29
1.41
1.1
1.2
—
—
—
0
0
6
23
2.64
1.37
1.5
1.4
—
—
—
0
0
220
2054
1.43
1.34
16.5
8.7
3.94
3.95
mmol/l
0.07
211
1995
114
972
1.30
1.31
4.7
2.7
0.00
0.00
estimate
-0.00
30
186
114
972
1.30
1.31
6.1
3.9
0.00
0.00
estimate
-0.00
29
183
63
493
1.36
1.30
5.2
2.4
11.43
42.48
e6/l
1.57
51
360
115
985
1.30
1.27
4.8
2.8
0.10
0.00
estimate
0.49
30
171
5
19
2.66
1.22
2.4
3.3
—
—
—
0
0
13
71
1.87
1.21
1.3
1.1
—
—
—
0
0
78
641
1.31
1.16
1.7
1.5
—
—
—
0
0
5
20
2.53
1.15
1.2
1.3
—
—
—
0
0
16
96
1.71
1.13
32.6
3.5
—
—
—
0
0
46
351
1.38
1.11
1.4
1.3
2.18
6.81
u/ml
1.40
19
150
236
2250
1.46
1.09
12.3
7.8
30.03
28.98
u/l
0.34
226
2196
43
326
1.38
1.08
1.5
1.6
—
—
—
0
0
7
33
2.15
1.06
1.1
1.1
—
—
—
0
0
19
122
1.60
1.06
28.2
6.3
—
—
—
0
0
62
500
1.31
1.05
1.6
1.6
1.61
1.52
mmol/l
0.23
55
446
7
34
2.09
1.03
3.1
2.0
23.80
22.98
mmol/l
—
7
34
202
1889
1.30
1.00
5.2
4.3
1.74
2.40
mu/l
0.55
190
1789
5
23
2.20
0.98
3.4
2.8
14.00
19.35
u/ml
—
5
23
131
1168
1.24
0.97
10.7
7.7
4.00
3.85
e9/l
0.30
121
1014
52
415
1.32
0.95
5.0
2.9
—
—
—
0
0
47
370
1.33
0.94
1.4
1.3
28.80
28.95
iu/ml
0.00
15
127
11
63
1.78
0.91
1.6
1.2
—
—
—
0
0
25
178
1.45
0.90
1.2
1.3
199.96
185.49
iu/ml
0.04
12
73
11
64
1.75
0.87
8.5
5.9
—
—
—
0
0
16
105
1.56
0.84
2.6
2.9
—
—
—
0
0
33
253
1.35
0.80
2.2
1.8
—
—
—
0
0
18
123
1.50
0.80
1.1
1.2
—
—
—
0
0
0
25
0.00
0.79
0.0
1.3
—
—
—
0
0
222
2123
1.29
0.76
14.9
8.7
21.48
19.36
mg/l
0.43
184
1567
15
218
0.67
0.75
1.1
1.4
—
—
—
0
0
7
39
1.82
0.73
2.4
1.6
—
—
—
0
0
5
25
2.02
0.73
4.0
1.7
—
—
—
0
0
16
109
1.50
0.73
2.1
1.3
—
—
—
0
0
41
330
1.29
0.72
1.5
1.3
19.38
20.39
nmol/l
0.16
36
295
19
135
1.44
0.71
22.8
4.0
—
—
—
0
0
58
490
1.24
0.69
8.9
5.7
—
—
—
0
0
13
86
1.54
0.67
1.4
1.2
—
—
—
0
0
70
605
1.21
0.67
6.2
3.0
27.08
151.74
e6/l
0.94
52
392
65
563
1.21
0.61
1.4
1.3
0.48
1.40
u/ml
2.26
17
166
32
256
1.28
0.60
4.6
2.4
1.94
2.50
e6/l
0.17
18
135
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
90
805
1.18
0.59
4.3
2.6
5.71
5.87
ph
—
7
91
6
35
1.73
0.58
1.0
1.1
—
—
—
0
0
59
510
1.20
0.57
1.5
1.3
2.20
2.18
g/l
0.04
38
326
6
37
1.64
0.56
1.0
1.0
—
—
—
0
0
67
590
1.18
0.53
4.0
2.3
—
—
—
0
0
65
571
1.18
0.53
1.6
1.7
91.88
95.96
pmol/l
0.36
35
301
201
1927
1.18
0.52
18.2
10.9
13.99
14.19
%
0.27
195
1907
47
403
1.20
0.50
4.0
3.4
9.41
6.16
mg/mmol
0.25
31
272
32
385
0.81
0.50
1.3
1.4
—
—
—
0
0
16
119
1.37
0.49
3.3
3.3
—
—
—
0
0
21
164
1.30
0.48
6.7
5.6
102.62
104.74
mmol/l
0.78
21
164
80
721
1.16
0.48
1.8
1.9
—
—
—
0
0
17
129
1.34
0.47
1.5
1.4
—
—
—
0
0
45
387
1.20
0.46
3.0
2.8
111.25
204.64
mg/l
0.21
31
264
45
387
1.20
0.46
3.4
2.7
—
—
—
0
0
38
323
1.21
0.44
4.2
2.6
128.73
70.12
ug/g
0.62
31
255
8
57
1.42
0.42
3.9
4.1
0.88
0.65
%
—
8
57
10
70
1.45
0.42
1.0
1.1
1.35
4.76
u/ml
—
5
39
28
232
1.23
0.42
1.1
1.2
—
—
—
0
0
8
58
1.39
0.42
3.0
2.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.9
—
—
—
0
0
232
2264
1.20
0.40
14.8
8.0
—
—
—
0
0
32
375
0.83
0.39
1.6
1.6
—
—
—
0
0
13
170
0.75
0.39
2.2
1.8
—
—
—
0
0
9
69
1.31
0.37
1.4
1.8
—
—
—
0
0
185
1782
1.13
0.36
4.8
4.1
38.66
38.09
mmol/mol
0.31
172
1713
57
512
1.14
0.36
3.4
2.7
8.73
8.97
mmol/l
0.12
49
467
6
43
1.40
0.35
1.7
1.3
—
—
—
0
0
25
295
0.83
0.34
1.8
2.2
0.66
0.62
ug/l
—
9
136
166
1593
1.11
0.34
4.2
2.8
41.94
42.04
u/l
0.01
156
1544
25
211
1.20
0.33
1.2
1.1
—
—
—
0
0
187
1925
0.90
0.29
3.8
3.5
5.87
5.72
mmol/l
0.63
172
1820
199
2042
0.90
0.29
4.0
3.6
1.40
1.44
mmol/l
0.85
187
1963
13
103
1.28
0.28
5.5
2.0
—
—
—
0
0
5
75
0.66
0.26
1.2
1.2
—
—
—
0
0
9
73
1.24
0.25
1.7
1.9
—
—
—
0
0
9
77
1.17
0.24
2.2
2.6
—
—
—
0
0
14
115
1.23
0.24
2.1
1.6
294.14
343.04
mu/l
0.25
14
104
15
179
0.83
0.24
2.5
2.0
—
—
—
0
0
15
178
0.83
0.22
2.5
2.0
—
—
—
0
0
15
178
0.83
0.22
3.2
2.0
—
—
—
0
0
15
178
0.83
0.22
2.5
1.8
—
—
—
0
0
15
126
1.20
0.21
1.1
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
1509.20
—
0
10
0
12
0.00
0.21
0.0
1.1
—
226.09
—
0
12
40
365
1.11
0.21
1.6
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
1.51
—
0
13
0
13
0.00
0.21
0.0
7.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
1.69
—
0
13
0
14
0.00
0.20
0.0
1.1
—
0.78
—
0
9
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
100
957
1.07
0.19
2.8
2.3
—
—
—
0
0
7
60
1.17
0.18
3.6
4.0
1.13
1.77
%
—
7
60
24
215
1.13
0.17
1.2
1.4
—
—
—
0
0
5
67
0.74
0.17
1.0
1.1
—
—
—
0
0
98
942
1.06
0.16
3.8
2.4
97.91
94.10
ug/l
0.08
91
895
48
449
1.08
0.16
5.2
2.7
1.02
1.02
kg/l
—
6
60
24
220
1.10
0.12
1.3
1.2
—
—
—
0
0
12
137
0.87
0.12
1.2
1.1
—
—
—
0
0
29
271
1.08
0.10
1.8
2.9
893.69
235.31
ng/l
0.52
19
163
6
56
1.07
0.08
1.0
1.1
—
13.96
—
0
5
6
57
1.05
0.08
1.0
1.2
—
—
—
0
0
204
2061
0.96
0.08
4.3
3.8
2.83
2.91
mmol/l
0.80
189
1972
7
66
1.06
0.08
5.1
7.6
—
—
—
0
0
207
2050
1.05
0.08
4.0
3.6
4.69
4.79
mmol/l
0.83
192
1975
15
163
0.92
0.07
2.5
2.1
—
—
—
0
0
196
1970
0.98
0.02
3.7
3.3
1.46
1.32
mmol/l
1.26
183
1882
13
136
0.95
0.00
2.5
2.2
—
—
—
0
0
24
234
1.03
0.00
1.7
1.4
—
—
—
0
0
246
2462
0.99
0.00
21.4
13.2
260.09
257.39
e9/l
0.29
239
2412
246
2459
1.01
0.00
21.6
13.1
40.67
41.35
%
1.08
237
2358
13
134
0.97
0.00
1.1
1.2
—
—
—
0
0
246
2465
0.97
0.00
21.4
13.2
7.51
6.58
e9/l
0.65
239
2408
246
2465
0.97
0.00
21.4
13.1
4.57
4.64
e12/l
1.38
239
2413
11
115
0.95
0.00
3.2
3.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
10.29
—
0
7
6
62
0.97
0.00
1.5
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
188.24
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
87
0.92
-0.00
1.5
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
84
0.95
-0.00
1.5
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
76
0.92
-0.00
11.9
7.6
1.34
1.56
%
—
7
76
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
75
0.93
-0.00
12.3
7.6
0.79
0.72
%
—
7
75
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
69
1.01
-0.00
4.3
3.8
124.57
140.09
g/l
—
7
69
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
7
73
0.96
-0.00
12.6
7.8
91.41
94.24
%
—
7
73
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
71
0.99
-0.00
1.9
2.7
—
—
—
0
0
8
87
0.92
-0.00
2.1
2.0
0.13
0.08
e6/l
—
8
81
8
84
0.95
-0.00
1.5
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
8
79
1.01
-0.00
1.9
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_SCARLET_FEVER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_SCARLET_FEVER.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: AB1_SCARLET_FEVER – Scarlet fever

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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