Tick-borne viral encephalitis

AB1_TICK_BORNE_ENCEPHALITIS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A84 Hospital discharge: ICD-9 — 06[3] Hospital discharge: ICD-8 — 06[3] Cause of death: ICD-10 — A84 Cause of death: ICD-9 — 06[3] Cause of death: ICD-8 — 06[3] 2 out of 7 registries used, show all original rules.	130
4. Check minimum number of events None	130
5. Include endpoints None	130
6. Filter based on genotype QC (FinnGen only)	130

Control definitions (FinnGen only)

Control exclude: AB1_VIRAL_CNS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5

NAME	AB1_TICK_BORNE_ENCEPHALITIS
CONTROL_EXCLUDE	AB1_VIRAL_CNS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A84
HD_ICD_9	06[3]
HD_ICD_8	06[3]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A84
COD_ICD_9	06[3]
COD_ICD_8	06[3]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Tick-borne viral encephalitis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1177	458	710
Only index persons	1085	435	650
Unadjusted period prevalence (%)
Whole population	0.02	0.01	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	49.62	50.46	48.87
Only index persons	50.10	50.59	49.77

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	130	64	66
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	54.11	54.54	53.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
118: Matched controls
1182

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A84.8

ICD-10 Finland

Other tick-borne viral encephalitis

+∞

55.7

A84.9

ICD-10 Finland

Tick-borne viral encephalitis, unspecified

+∞

52.0

A86

ICD-10 Finland

Unspecified viral encephalitis

+∞

28.3

TAB00

NOMESCO Finland

Lumbar puncture

18.6

20.0

XA800

NOMESCO Finland

Neuropsychological investigation

17.1

17.6

A87.9

ICD-10 Finland

Viral meningitis, unspecified

+∞

16.0

R50.9

ICD-10 Finland

Fever, unspecified

5.4

11.1

G04.9

ICD-10 Finland

Encephalitis, myelitis and encephalomyelitis, unspecified

+∞

9.5

A69.2

ICD-10 Finland

Lyme disease

8.7

9.4

R4120

NOMESCO Finland

Occupational therapy

7.3

8.8

0632A

ICD-9 Finland

Tick-borne viral encephalitis, Central European encephalitis[PUUTIAISEN VÄLITTÄMÄ ENKEFALIITTI (KUMLINGE)]

+∞

8.4

A84.1

ICD-10 Finland

Central European tick-borne encephalitis

+∞

8.4

AA1AD

NOMESCO Finland

CT of head and brain

3.4

7.6

170

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

6.0

7.4

R4150

NOMESCO Finland

Neuropsychological rehabilitation

28.3

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3044290) Cell count panel - Cerebral spinal fluid

49.02

83.95

1.2

—

(3023410) Appearance of Cerebral spinal fluid

38.01

52.01

1.1

1.3

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

23.49

50.96

1.1

97.4

3.5

e6/l

2.22

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

23.49

50.96

1.1

1.3

42.8

333.3

e6/l

0.61

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

13.66

48.75

3.4

2.4

28.6

6.7

au/ml

—

(3016018) Differential panel - Cerebral spinal fluid

100.26

43.54

1.2

1.3

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

98.49

38.66

1.1

1.0

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

114.07

38.39

1.0

1.4

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

114.07

38.39

1.2

1.4

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

71.29

35.99

1.2

1.4

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

18.51

32.37

1.4

1.2

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

25.19

30.99

1.2

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

16.15

18.83

1.2

2.2

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

8.97

17.59

1.1

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

12.90

17.48

1.1

1.3

—

(3023368) Bacteria identified in Blood by Culture

276

4.46

16.20

3.7

4.7

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

8.75

15.31

1.1

1.4

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

15.57

15.28

1.2

2.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

7.25

11.91

1.4

2.2

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

22.54

11.45

1.1

1.0

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

10.21

10.95

1.0

1.3

—

(42870588) Differential panel, method unspecified - Blood

344

3.34

10.51

5.2

6.2

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

21.83

8.64

1.0

1.2

—

(3007080) Epstein Barr virus nuclear IgG Ab [Units/volume] in Serum

8.16

8.56

1.0

1.5

270.9

157.2

u/ml

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

19.83

7.74

1.1

1.0

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

6.86

7.38

1.0

1.5

—

(3019069) Monocytes/100 leukocytes in Blood

496

2.68

6.84

6.2

6.7

8.4

8.5

0.13

465

(3019225) pH of Specimen

3.40

6.44

3.0

4.7

—

(3002030) Lymphocytes/100 leukocytes in Blood

508

2.58

6.33

6.1

6.6

24.6

27.4

1.15

477

(3022096) Basophils/100 leukocytes in Blood

481

2.55

6.31

6.0

6.5

0.5

0.7

2.17

445

(3041365) Herpes simplex virus IgG Ab [Units/volume] in Serum by Immunoassay

+∞

6.29

1.0

0.0

—

(3006504) Eosinophils/100 leukocytes in Blood

494

2.53

6.15

6.0

6.5

1.9

2.8

3.42

457

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.73

5.70

1.5

1.8

—

(3033658) Prothrombin time (PT) actual/Normal

270

2.46

5.58

3.5

4.0

88.5

93.6

0.81

264

(3025927) Herpes simplex virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

+∞

5.24

1.0

0.0

—

(3013115) Eosinophils [#/volume] in Blood

541

2.24

4.72

6.1

7.0

0.1

0.2

e9/l

3.80

480

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

476

2.22

4.71

3.0

5.7

1.2

mmol/l

1.50

432

(46235355) HIV 1 and 2 tests - Meaningful Use set

168

2.48

4.63

1.4

1.9

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

5.08

4.61

1.0

1.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

715

2.40

4.60

3.6

4.2

—

(3001604) Monocytes [#/volume] in Blood

527

2.20

4.55

5.9

6.6

0.6

e9/l

0.31

459

(3006315) Basophils [#/volume] in Blood

527

2.20

4.55

5.9

6.6

0.0

e9/l

0.71

460

(3048929) Epstein Barr virus Ab [Presence] in Serum

4.31

4.55

1.3

1.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

171

2.43

4.44

1.6

2.0

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

4.84

4.38

1.0

1.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

507

2.13

4.28

3.4

6.8

1.2

mmol/l

0.64

425

(3019198) Lymphocytes [#/volume] in Blood

537

2.13

4.22

5.9

6.6

1.9

1.8

e9/l

0.23

477

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

568

2.06

3.85

4.9

6.9

10.6

11.2

umol/l

0.31

540

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

178

2.23

3.64

2.2

3.1

2.3

e6/l

0.16

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

3.66

3.41

1.2

2.6

—

(40768804) Tissue Pathology biopsy report

417

1.93

3.33

2.1

2.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

679

1.99

3.25

2.7

3.1

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

5.60

3.24

1.1

1.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.63

3.13

1.2

2.2

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.20

3.06

1.3

2.0

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

626

1.90

3.05

7.8

10.5

4.7

4.2

e9/l

0.73

546

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

392

1.87

2.99

1.9

2.0

86.7

92.2

pmol/l

0.34

187

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.53

2.97

1.1

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

4.94

2.97

1.1

1.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

121

1074

2.83

2.93

16.1

14.2

21.0

23.5

mg/l

0.43

110

840

(3013707) Erythrocyte sedimentation rate by Westergren method

797

2.02

2.92

3.9

4.1

12.6

11.3

mm/h

0.44

742

(3007164) IgA [Mass/volume] in Serum or Plasma

219

1.96

2.82

1.3

1.4

2.0

2.7

g/l

1.14

130

(3002582) Erythrocytes [#/volume] in Urine

336

1.85

2.82

2.6

3.4

31.6

229.8

e6/l

0.50

251

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

189

2.00

2.76

3.5

4.0

13.8

91.0

ng/l

1.59

145

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

191

1.98

2.67

2.2

2.9

0.7

1.0

e6/l

0.41

102

(3017446) Testosterone [Moles/volume] in Serum or Plasma

105

2.19

2.48

1.7

2.5

12.0

13.5

nmol/l

0.43

(3018095) Leukocytes [#/volume] in Urine

375

1.75

2.44

3.4

4.0

10.5

52.9

e6/l

2.44

266

(36304419) Bacteria [Presence] in Urine

305

1.79

2.44

2.8

3.1

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

4.78

2.30

1.2

1.1

—

(3030467) Casts [#/volume] in Urine by Automated count

310

1.75

2.28

2.8

3.2

0.2

0.3

e6/l

0.31

222

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

381

1.71

2.28

2.6

3.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

124

2.04

2.25

1.7

1.8

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

5.72

2.23

1.2

1.0

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

140

1.97

2.21

5.1

4.1

33.8

32.3

0.22

(3002523) Influenza virus A Ag [Presence] in Specimen

4.44

2.17

1.2

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

4.44

2.17

1.2

1.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

402

0.53

2.13

2.0

3.7

—

(3032080) INR in Blood by Coagulation assay

397

1.67

2.10

5.4

7.8

1.1

1.2

inr

—

119

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.23

2.07

1.6

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

3.88

1.96

1.0

1.1

—

(3035637) Corticotropin [Mass/volume] in Plasma

4.29

1.84

1.2

—

(1761868) Lipid panel - Serum or Plasma

421

0.57

1.83

2.5

2.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

142

1.85

1.80

1.3

1.6

—

(40758558) Short blood count panel - Blood

293

1.64

1.78

6.6

7.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.13

1.78

1.4

1.7

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.02

1.75

1.0

1.1

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

209

1.70

1.73

3.4

2.9

0.5

0.7

ug/l

1.14

136

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

129

1.85

1.70

1.7

1.8

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

123

1144

2.40

1.69

17.1

16.6

73.7

78.6

umol/l

2.29

123

1144

(3021788) Differential panel - Synovial fluid

3.67

1.63

1.2

1.3

—

(1002224) Polysomnography panel

2.22

1.60

1.0

1.1

—

(3013512) EKG study

309

1.59

1.60

3.8

3.7

—

(3003396) Base excess in Arterial blood by calculation

101

1.91

1.58

2.5

7.0

2.6

1.3

mmol/l

0.85

(40760892) CBC W Ordered Manual Differential panel - Blood

236

0.50

1.57

4.5

6.3

—

(36660697) Celiac disease serology panel - Serum

1.96

1.47

1.2

1.1

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

2.81

1.45

1.5

1.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

128

1.76

1.44

1.6

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

0.00

1.37

0.0

4.2

—

1.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.94

1.36

1.0

1.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

110

996

1.68

1.31

19.3

14.5

38.7

40.9

1.14

754

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.85

1.29

1.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

287

1.51

1.28

3.5

4.3

21.7

21.1

0.05

122

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.47

1.26

1.2

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

299

0.61

1.22

2.1

3.0

—

(40768443) Skin Pathology biopsy report

2.12

1.17

1.0

1.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

395

1.43

1.14

2.8

3.9

80.6

29.1

ng/l

0.42

280

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

2.25

1.10

1.1

2.3

0.0

g/l

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

2.25

1.10

1.1

2.3

0.0

g/l

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

106

1.69

1.09

4.1

2.1

31.6

30.0

u/l

0.11

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

361

1.42

1.08

4.7

4.3

3.5

1.8

ug/l

0.60

325

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.07

1.07

2.3

6.8

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

2.12

1.04

1.1

2.2

0.0

g/l

—

(3037756) Immunofixation for Serum or Plasma

2.32

1.04

1.0

1.4

—

(3025941) Bacteria identified in Stool by Culture

1.88

1.02

1.2

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.06

1.01

1.0

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.06

1.01

1.0

1.2

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.06

1.01

1.1

1.6

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.06

1.01

1.0

1.2

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

422

1.39

1.00

2.3

2.4

73.2

75.8

nmol/l

0.28

380

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.92

0.99

2.2

5.9

24.8

24.9

mmol/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.86

0.99

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.28

0.95

1.2

1.7

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.28

0.95

1.2

1.7

—

(3044889) 12 lead EKG panel

739

0.74

0.94

3.5

3.9

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.20

0.93

1.2

2.0

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.20

0.93

1.2

1.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

145

1.53

0.92

1.3

1.4

—

(4010399)

1.66

0.88

1.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.82

0.86

1.1

1.4

—

(4035726)

1.64

0.85

1.3

1.4

—

(4094501)

1.92

0.83

1.2

1.1

—

(4034850)

0.00

0.78

0.0

15.7

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

418

1.32

0.76

2.4

2.9

176.2

118.3

ug/l

0.75

390

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

108

0.53

0.76

1.7

2.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

2.13

0.75

1.0

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

126

1.50

0.75

6.7

8.1

—

(3026493) Urate [Moles/volume] in Serum or Plasma

278

1.35

0.75

2.0

2.8

14183.4

1257.2

umol/l

0.45

244

(3022621) pH of Urine by Test strip

1.67

0.74

2.1

1.8

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.57

0.73

1.9

2.7

0.2

g/l

0.26

(3015377) Calcium [Moles/volume] in Serum or Plasma

354

1.32

0.73

3.0

3.6

2.3

2.4

mmol/l

1.03

315

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

105

979

1.38

0.70

4.5

4.6

1.7

1.9

mu/l

0.73

892

(3002385) Erythrocyte distribution width [Ratio]

914

0.77

0.67

22.2

17.3

13.7

13.6

0.11

905

(3036481) Cortisol [Moles/volume] in Serum or Plasma

112

1.49

0.67

2.0

1.8

264.6

368.2

nmol/l

1.88

101

(3034770) Mitochondria Ab [Titer] in Serum

1.82

0.67

1.4

1.1

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.69

0.62

1.2

1.8

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.61

0.62

1.0

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

113

0.60

0.61

2.7

3.7

—

(3044640) Blood type and Crossmatch panel - Blood

318

1.28

0.56

2.6

2.2

—

(3019060) Gas panel - Arterial blood

1.54

0.56

2.6

4.0

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.61

0.55

1.3

1.2

—

(3035941) MCH [Entitic mass]

124

1203

1.67

0.54

22.9

20.3

30.2

30.4

0.50

124

1186

(3024731) MCV [Entitic volume]

124

1203

1.67

0.54

22.9

20.4

90.6

91.1

0.48

124

1186

(3021960) Folate [Moles/volume] in Serum or Plasma

264

1.28

0.53

1.5

1.6

16.9

22.4

nmol/l

2.39

227

(3019150) Specific gravity of Urine by Refractometry

219

0.74

0.49

1.6

4.1

1.0

kg/l

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

118

0.66

0.48

1.6

1.7

—

(3021589) Normoblasts [#/volume] in Blood

488

1.22

0.48

7.9

9.8

0.0

e9/l

0.27

403

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

230

1.28

0.48

1.5

1.7

1.0

mg/l

0.12

186

(3022313) Gas panel - Capillary blood

1.48

0.47

3.7

3.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

240

1.27

0.47

2.6

2.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

107

1019

1.28

0.45

15.8

13.6

83.6

82.1

ml/min/173m2

0.37

842

(3014007) Fractional oxyhemoglobin in Arterial blood

1.48

0.44

3.1

9.0

96.0

93.8

—

(3000963) Hemoglobin [Mass/volume] in Blood

124

1205

1.63

0.44

23.1

20.5

134.5

137.3

g/l

1.49

124

1186

(40768797) Stomach Pathology biopsy report

151

1.30

0.41

1.1

1.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

106

1102

0.79

0.40

5.2

4.9

2.9

2.8

mmol/l

1.02

1023

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.00

0.39

0.0

2.3

—

195.8

—

(40761511) CBC panel - Blood by Automated count

117

1132

1.34

0.38

13.2

12.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

108

1.33

0.37

1.7

—

(3020682) Albumin/Creatinine [Ratio] in Urine

315

0.82

0.36

2.7

4.0

7.8

7.9

mg/mmol

0.01

195

(3000330) Specific gravity of Urine by Test strip

1.41

0.35

2.5

3.3

—

(3022145) Colonoscopy Study observation

118

1.31

0.35

1.7

1.3

—

(3000991) Gas panel - Venous blood

1.35

0.35

1.8

8.2

—

(3009508) Creatinine [Moles/volume] in Urine

324

0.83

0.34

2.0

3.2

8.6

8.1

mmol/l

0.17

271

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.31

0.31

2.4

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

798

1.15

0.28

3.5

3.9

15.4

14.9

pmol/l

0.55

722

(3012516) Albumin [Mass/volume] in Urine

295

0.85

0.26

2.0

3.3

55.2

52.8

mg/l

0.03

189

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

228

1.18

0.25

2.2

2.1

4.0

2.9

mg/l

0.48

201

(3045414) Leukocytes [Presence] in Urine

1.37

0.24

2.4

1.6

—

(3019309) Folate [Moles/volume] in Red Blood Cells

182

1.18

0.23

1.4

1.7

847.4

1215.0

nmol/l

1.31

136

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

1.29

0.23

4.2

3.3

1780.2

232.4

u/ml

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.2

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.21

0.0

4.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.9

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.21

0.0

1.0

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

105

1078

0.86

0.21

5.1

4.4

1.5

1.4

mmol/l

0.63

999

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.26

0.20

1.2

3.8

0.0

0.1

e6/l

—

(3042936) Bacteria identified in Isolate by Culture

158

1.16

0.17

1.8

1.9

—

(3015736) pH of Urine

397

0.90

0.16

2.2

3.5

—

(3003694) ABO and Rh group [Type] in Blood

266

1.12

0.15

1.2

1.4

—

(3000492) Spirometry study

109

0.81

0.13

1.3

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

201

1.11

0.12

1.4

1.6

—

(3012544) pH of Venous blood

1.17

0.12

1.6

4.9

—

(3000494) Fungus identified in Specimen by Culture

135

0.88

0.10

1.2

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

135

1.13

0.10

1.5

1.7

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

307

0.93

0.09

1.6

1.7

1.3

1.4

mmol/l

0.42

260

(3001019) Free T4 and TSH panel - Serum or Plasma

1.04

0.08

1.3

1.7

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.06

0.08

1.3

1.2

—

138.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

235

1.08

0.08

2.6

3.8

—

(3026008) Bacteria identified in Urine by Culture

295

1.07

0.07

2.1

2.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

454

1.06

0.07

3.4

3.8

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

102

1006

1.06

0.06

5.2

5.4

39.4

39.7

mmol/mol

0.13

945

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

107

1082

0.94

0.05

5.1

4.4

4.8

4.7

mmol/l

0.75

1010

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

106

1050

1.05

0.03

4.5

3.9

1.2

1.3

mmol/l

1.08

965

(21494755) Public health laboratory ask at order entry panel

127

0.94

0.01

1.1

1.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

104

1039

1.00

0.00

4.5

5.9

mmol/l

0.12

955

(3002256) Pathology report gross observation

122

0.98

0.00

1.4

1.2

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

128

1.02

0.00

3.3

7.0

0.9

1.0

mmol/l

1.06

114

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

115

1.05

0.00

1.5

1.6

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.2

—

13.3

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

12.4

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.7

—

38.0

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

55.8

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.98

0.00

1.2

3.2

0.7

1.2

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

2.6

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.2

—

(3004451) EKG impression Narrative

0.00

0.0

1.7

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

3.2

—

113.4

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.92

0.00

1.4

1.5

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(4024509)

0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

14.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.7

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.9

—

0.9

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.6

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

8.8

—

0.7

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.0

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.0

2.0

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.8

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

0.0

1.6

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.4

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.3

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

4.0

—

82.4

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

16.1

—

1063.0

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.3

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

12.6

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.8

—

76.6

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.6

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

18.6

—

2171.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_TICK_BORNE_ENCEPHALITIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_TICK_BORNE_ENCEPHALITIS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_TICK_BORNE_ENCEPHALITIS – Tick-borne viral encephalitis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Tick-borne viral encephalitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints