No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
233 |
4. Check minimum number of eventsNone |
233 |
5. Include endpointsNone |
233 |
6. Filter based on genotype QC (FinnGen only) |
233 |
Control definitions (FinnGen only)
- Control exclude
- AB1_OTHER_BACTERIAL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Whooping cough
based on the number of shared cases.
Similar with more cases:
- Other bacterial diseases
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3514 | 1889 | 1610 |
| Only index persons | 2916 | 1595 | 1321 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.06 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 2.90 | 3.61 | 1.74 |
| Only index persons | 4.07 | 5.08 | 2.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 233 | 160 | 73 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.03 |
| Median age at first event (years) | 10.67 | 9.71 | 12.76 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 208
- Matched controls
- 2080
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A37.0
ICD-10 Finland
Whooping cough due to Bordetella pertussis
+∞
66.3
60
*
A37.9
ICD-10 Finland
Whooping cough, unspecified
+∞
63.9
58
*
03397
ICD-8 Finland
Whooping cough, Suspecta
+∞
22.3
21
*
03300
ICD-8 Finland
Whooping cough, Bordetalla Pertussis
+∞
16.9
16
*
0330A
ICD-9 Finland
Whooping cough, Bordetella pertussis [B. pertussis][PERTUSSIS CAUSA BORDETELLA PERTUSSIS,EI ROKOTETULLA]
+∞
13.7
13
*
03399
ICD-8 Finland
Whooping cough, Other and unspecified
+∞
11.6
11
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
126.7
11.5
12
*
R05
ICD-10 Finland
Cough
3.6
11.3
57
198
0330B
ICD-9 Finland
Whooping cough, Bordetella pertussis [B. pertussis][PERTUSSIS CAUSA BORDETELLA PERTUSSIS,ROKOTETULLA]
+∞
10.5
10
*
R03AC02
ATC
salbutamol; inhalant
2.6
10.4
129
793
J45.9
ICD-10 Finland
Asthma, unspecified
3.1
7.7
44
165
R03BC03
ATC
nedocromil; inhalant
5.1
7.6
23
49
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
7.5
70
352
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.9
7.4
48
194
R03BA05
ATC
fluticasone; inhalant
2.8
7.3
50
208
R03AC12
ATC
salmeterol; inhalant
8.0
7.0
15
20
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
6.6
50
222
J01FA10
ATC
azithromycin; systemic
2.2
6.6
150
1118
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.0
6.5
40
155
0339A
ICD-9 Finland
Whooping cough, unspecified organism[PERTUSSIS NUD, EI ROKOTETULLA]
+∞
6.3
6
*
A46
ICD-10 Finland
Erysipelas
6.4
6.1
15
25
J01FA06
ATC
roxithromycin; oral
2.2
6.1
82
483
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
74
374
2.43
8.52
1.9
1.7
1.0
1.0
mg/l
0.02
54
276
46
187
2.82
8.21
1.8
1.8
—
—
—
0
0
85
511
2.04
6.09
2.0
1.6
101.9
98.1
pmol/l
0.26
46
264
23
76
3.25
5.83
2.7
2.9
0.2
1.3
mmol/l
0.86
15
50
141
1026
1.95
5.69
10.8
7.5
4.1
3.9
e9/l
0.29
123
894
40
183
2.43
5.56
1.6
1.5
1231.7
1105.0
nmol/l
0.31
29
143
128
917
1.88
5.26
6.0
3.5
6.9
6.3
mmol/l
1.66
117
802
32
138
2.53
5.03
1.5
1.7
—
—
—
0
0
32
138
2.53
5.03
1.6
1.8
—
—
—
0
0
10
20
5.18
4.82
1.1
1.8
—
—
—
0
0
76
473
1.90
4.74
4.4
2.6
2.3
2.4
mmol/l
0.77
67
416
59
337
2.01
4.72
4.9
4.1
10.0
13.0
mg/mmol
0.21
43
219
33
151
2.38
4.57
5.5
2.1
21.4
24.6
%
0.85
26
130
35
167
2.29
4.41
4.8
2.0
2.4
2.5
g/l
0.17
30
150
58
345
1.91
4.09
2.0
2.3
7612.2
4517.6
umol/l
0.16
53
314
58
347
1.89
4.01
3.6
1.7
—
—
—
0
0
96
675
1.72
3.85
2.7
2.3
71.1
73.9
nmol/l
0.41
86
620
9
15
6.19
3.85
1.0
1.9
—
—
—
0
0
93
651
1.71
3.78
11.9
5.1
1.2
1.2
mmol/l
0.73
77
559
26
119
2.33
3.60
17.2
5.8
104.8
104.5
mmol/l
0.14
26
113
13
41
3.30
3.55
2.6
1.9
—
—
—
0
0
9
17
5.46
3.54
1.0
1.8
—
—
—
0
0
82
565
1.70
3.48
1.3
1.4
0.8
1.3
u/ml
1.08
21
142
120
921
1.62
3.30
3.7
2.7
111.4
65.8
ug/l
1.96
109
863
17
66
2.70
3.29
1.1
1.1
—
—
—
0
0
7
11
6.52
3.21
1.0
2.0
—
—
—
0
0
17
67
2.66
3.20
1.4
1.3
—
—
—
0
0
60
388
1.74
3.17
2.0
2.1
2.7
2.6
mg/l
0.03
43
334
7
12
5.98
3.04
1.0
2.0
—
—
—
0
0
34
186
1.97
3.03
1.6
2.5
8.9
6.5
umol/l
0.32
23
151
9
21
4.41
3.02
1.1
1.8
—
—
—
0
0
5
5
10.18
2.99
1.0
1.0
—
—
—
0
0
5
5
10.18
2.99
1.0
2.6
—
—
—
0
0
74
516
1.64
2.93
4.0
2.7
—
—
—
0
0
105
801
1.57
2.83
5.1
3.6
—
—
—
0
0
5
6
8.48
2.76
1.0
2.3
—
—
—
0
0
7
14
5.12
2.75
1.1
1.8
—
—
—
0
0
67
464
1.62
2.70
2.9
2.0
45.5
56.2
u/l
4.10
62
426
10
32
3.22
2.68
1.2
1.1
—
—
—
0
0
12
44
2.82
2.59
7.1
3.8
47.3
49.9
%
0.11
12
44
40
245
1.76
2.53
1.7
1.5
390.1
30454996.9
pmol/l
0.50
35
220
19
89
2.24
2.52
1.9
1.4
—
—
—
0
0
65
454
1.60
2.51
2.4
2.5
86.4
22.1
ng/l
0.43
29
215
7
16
4.48
2.49
1.3
1.0
—
1.0
—
0
5
17
77
2.30
2.44
1.5
1.5
—
—
—
0
0
8
22
3.73
2.38
1.3
1.2
—
—
—
0
0
8
22
3.73
2.38
1.3
1.2
—
—
—
0
0
15
65
2.40
2.37
1.2
1.1
2.3
2.8
u/ml
—
7
30
79
585
1.53
2.35
11.0
4.4
1.2
1.2
mmol/l
0.41
72
537
170
1478
1.56
2.32
5.8
4.1
40.6
37.7
mmol/mol
2.45
160
1394
17
79
2.24
2.31
4.5
3.4
5.5
2.9
ug/l
0.66
11
61
57
394
1.59
2.29
2.0
2.0
164.8
333.3
u/l
0.50
50
378
11
43
2.64
2.13
1.4
1.4
—
—
—
0
0
14
62
2.34
2.12
2.2
1.6
—
—
—
0
0
5
11
4.62
1.95
1.2
2.0
—
—
—
0
0
5
11
4.62
1.95
1.0
2.0
—
—
—
0
0
213
1985
1.85
1.90
11.2
7.3
25.9
26.4
u/l
0.11
208
1915
7
22
3.25
1.89
1.3
1.5
—
—
—
0
0
165
1454
1.46
1.87
4.6
3.9
14.3
14.5
pmol/l
0.59
156
1332
7
23
3.10
1.81
1.4
1.1
—
—
—
0
0
10
41
2.50
1.78
2.9
1.9
—
—
—
0
0
8
30
2.72
1.74
1.5
1.6
—
—
—
0
0
10
42
2.44
1.70
1.1
1.1
—
—
—
0
0
44
307
1.53
1.69
1.4
1.4
21.3
20.8
nmol/l
0.09
37
274
36
240
1.59
1.68
4.2
2.6
6.4
3.2
e6/l
0.54
18
128
23
136
1.77
1.66
1.7
1.8
—
—
—
0
0
20
115
1.81
1.58
4.8
2.4
—
—
—
0
0
28
178
1.65
1.57
1.4
1.3
114.7
135.6
iu/ml
—
10
69
13
64
2.09
1.57
2.4
1.9
3.0
6.8
iu/l
—
5
22
10
44
2.33
1.55
1.0
1.3
—
—
—
0
0
11
51
2.21
1.53
1.3
1.3
—
—
—
0
0
5
16
3.17
1.44
1.4
1.7
—
—
—
0
0
18
104
1.79
1.41
12.6
3.7
187.4
68.2
ng/l
1.26
18
95
36
252
1.51
1.37
4.2
2.3
1.8
0.9
e6/l
0.43
18
140
16
90
1.84
1.37
15.6
4.3
25.1
24.7
mmol/l
0.25
16
90
187
1725
1.43
1.34
5.5
4.4
1.7
1.8
mu/l
0.29
178
1608
179
1643
1.39
1.29
15.4
7.4
93.1
95.0
ml/min/173m2
0.45
155
1297
5
18
2.82
1.29
1.4
1.4
—
—
—
0
0
5
18
2.82
1.29
2.6
2.3
17.2
16.3
%
—
5
9
203
1907
1.50
1.26
18.1
8.6
19.8
19.3
mg/l
0.10
176
1373
55
426
1.38
1.24
4.3
2.5
0.2
0.2
e6/l
0.57
42
310
179
1649
1.37
1.21
3.8
3.2
5.9
5.6
mmol/l
2.51
171
1512
35
251
1.46
1.20
3.3
3.0
96.3
213.2
ng/l
0.60
20
145
104
893
1.30
1.16
6.2
4.3
0.0
0.0
estimate
0.50
22
196
105
904
1.29
1.14
4.1
3.1
0.1
0.0
estimate
0.48
21
186
145
1310
1.28
1.05
5.1
3.5
11.3
8.2
mm/h
1.53
137
1205
103
895
1.27
1.01
4.1
3.0
0.0
0.0
estimate
0.00
19
188
43
331
1.37
1.01
1.4
1.3
8.8
26.7
iu/ml
—
8
108
5
23
2.20
0.98
2.0
2.4
—
—
—
0
0
13
77
1.73
0.97
5.7
2.5
0.1
0.1
e6/l
0.22
13
72
28
201
1.45
0.97
2.4
2.4
5217.1
4750.6
u/l
—
10
92
14
86
1.67
0.93
1.2
1.5
—
—
—
0
0
6
34
1.78
0.77
1.0
2.1
—
—
—
0
0
5
24
2.11
0.75
8.8
2.3
—
—
—
0
0
32
248
1.34
0.74
3.1
3.0
2352.9
667.9
ng/l
0.67
26
191
51
424
1.26
0.71
1.5
1.6
1.5
1.4
mmol/l
0.33
43
370
10
61
1.67
0.69
1.2
1.2
—
—
—
0
0
5
28
1.80
0.66
1.0
2.1
0.0
0.0
g/l
—
5
28
5
28
1.80
0.66
1.0
2.1
0.0
0.0
g/l
—
5
28
10
62
1.64
0.66
1.2
1.2
—
—
—
0
0
17
233
0.71
0.65
1.2
1.5
—
—
—
0
0
5
29
1.74
0.64
1.0
2.3
0.0
0.0
g/l
—
5
29
11
71
1.58
0.63
2.0
1.9
37.7
38.4
u/l
0.05
11
64
8
50
1.62
0.62
1.3
1.3
—
19.5
—
0
5
12
80
1.53
0.61
1.3
1.5
—
—
—
0
0
172
1630
1.21
0.61
3.7
3.0
1.4
1.2
mmol/l
1.92
160
1536
10
64
1.59
0.59
1.3
1.5
33.7
33.8
nmol/l
—
10
64
179
1705
1.22
0.58
3.9
3.8
—
—
—
0
0
179
1708
1.21
0.56
4.1
3.4
4.6
4.7
mmol/l
0.46
171
1611
6
38
1.59
0.54
1.0
1.0
—
—
—
0
0
78
700
1.17
0.51
4.2
3.0
—
—
—
0
0
177
1694
1.19
0.49
4.0
3.3
1.3
1.5
mmol/l
4.54
168
1595
24
298
0.78
0.49
1.7
1.8
—
—
—
0
0
7
45
1.57
0.49
30.0
8.3
1.0
1.0
%
—
7
45
10
142
0.69
0.48
1.5
1.6
—
—
—
0
0
38
322
1.22
0.46
1.3
1.2
1.6
7.5
u/ml
2.59
15
139
31
370
0.81
0.46
2.2
1.9
—
—
—
0
0
5
31
1.63
0.43
1.6
1.2
—
—
—
0
0
50
439
1.18
0.42
1.6
1.5
—
—
—
0
0
5
34
1.48
0.40
1.0
1.7
—
—
—
0
0
10
71
1.43
0.40
1.2
1.3
—
—
—
0
0
178
1720
1.15
0.36
4.4
3.6
2.8
2.8
mmol/l
0.01
170
1610
13
164
0.78
0.32
1.8
1.5
—
—
—
0
0
11
84
1.32
0.30
19.8
6.6
109.7
125.6
g/l
1.45
11
77
195
1904
1.15
0.29
20.3
9.3
39.2
40.6
%
1.34
149
1596
8
65
1.24
0.27
5.0
2.3
—
—
—
0
0
52
479
1.11
0.23
3.7
3.3
0.0
0.0
estimate
0.80
21
194
16
134
1.21
0.23
4.3
4.4
—
—
—
0
0
175
1706
1.10
0.23
22.9
10.8
13.5
13.3
%
1.08
168
1680
5
38
1.32
0.23
1.2
1.1
—
—
—
0
0
22
191
1.17
0.23
1.8
1.4
—
—
—
0
0
5
40
1.26
0.22
1.8
1.2
10.4
60.0
e6/l
—
5
33
5
40
1.26
0.22
1.4
1.0
20.0
2.9
e6/l
—
5
31
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
3.5
—
20.4
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
5
43
1.17
0.21
1.6
1.2
413.0
455.6
mg/l
—
5
43
13
155
0.83
0.21
2.5
2.4
0.4
0.7
ug/l
—
7
78
11
91
1.22
0.18
2.2
1.3
—
—
—
0
0
15
129
1.17
0.17
1.3
1.7
—
—
—
0
0
5
68
0.73
0.17
1.2
1.3
—
—
—
0
0
13
111
1.18
0.16
2.2
2.1
—
—
—
0
0
12
102
1.19
0.15
26.8
5.2
1.0
1.4
mmol/l
1.27
12
95
18
161
1.13
0.13
1.1
1.0
—
—
—
0
0
69
665
1.05
0.10
2.0
1.7
—
—
—
0
0
6
57
1.05
0.08
1.8
1.6
—
0.0
—
0
9
5
63
0.79
0.08
1.2
1.5
—
—
—
0
0
10
112
0.89
0.07
1.5
1.5
—
—
—
0
0
16
152
1.06
0.02
1.7
1.3
—
—
—
0
0
28
288
0.97
0.02
1.6
1.5
—
—
—
0
0
55
542
1.02
0.01
2.3
2.2
—
—
—
0
0
14
146
0.96
0.00
1.8
1.5
—
—
—
0
0
14
146
0.96
0.00
1.8
1.5
—
—
—
0
0
14
146
0.96
0.00
1.8
1.5
—
—
—
0
0
14
146
0.96
0.00
1.7
1.5
—
—
—
0
0
14
137
1.02
0.00
1.9
2.4
—
14.1
—
0
10
59
593
0.99
0.00
2.5
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
4.1
—
96.4
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
3.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
9.6
—
0
6
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
4.5
—
186.3
—
0
8
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
200.0
—
0
5
0
8
0.00
0.00
0.0
3.3
—
106.5
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
0.00
1.8
5.6
23.2
24.5
mmol/l
—
5
50
Mortality – FinRegistry
↥Association
Association between endpoint AB1_WHOOPCOUGH and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have AB1_WHOOPCOUGH.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: AB1_WHOOPCOUGH – Whooping cough
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data