Malignant neoplasm of ureter, excluding all cancers (controls excluding all cancers)

C3_URETER_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C66
  • Hospital discharge: ICD-9 189[2-3]
  • Hospital discharge: ICD-8 1892
  • Cause of death: ICD-10 C66
  • Cause of death: ICD-9 189[2-3]
  • Cause of death: ICD-8 1892
  • Cancer registry: Topography ICD-O-3 C66
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

269

4. Check minimum number of events

None

269

5. Include endpoints

None

269

6. Filter based on genotype QC (FinnGen only)

269

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of ureter, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 269 77 192
Unadjusted period prevalence (%) 0.07 0.03 0.08
Median age at first event (years) 72.53 72.29 72.63

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
74
Matched controls
740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C66
ICD-10 Finland
Malignant neoplasm of ureter
+∞
84.2
64
*
8120/3-C66.9
ICD-O-3
Transitional cell carcinoma, NOS, of ureter
+∞
80.6
62
*
UKC02
NOMESCO Finland
Cystoscopy
86.3
49.4
67
73
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
37.8
33
*
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
193.7
34.0
33
*
UKB02
NOMESCO Finland
Retrograde ureteroscopy
276.6
33.8
32
*
R31
ICD-10 Finland
Unspecified haematuria
24.0
29.1
46
47
D41.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Ureter
+∞
27.9
25
*
KAC20
NOMESCO Finland
Nephroureterectomy
+∞
27.9
25
*
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
+∞
26.7
24
*
KCD02
NOMESCO Finland
Transurethral resection of bladder
130.8
25.6
26
*
130
Kela drug reimbursment
Malignant tumour
+∞
23.1
21
*
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
109.0
22.1
23
*
KCD05
NOMESCO Finland
Excision of bladder lesion during urinary tract endoscopy with photodynamic diagnosis (PDD)
+∞
20.8
19
*
KAC21
NOMESCO Finland
Percutaneous endoscopic nephroureterectomy
+∞
17.4
16
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
14.0
13
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
22.3
14.0
20
12
TPH07
NOMESCO Finland
Cathetrisation of artery
10.8
13.3
27
37
WX302
NOMESCO Finland
Thoracal epidural anesthesy
27.0
12.7
17
8
D41.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bladder
56.6
12.4
14
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
10.9
12.1
24
31
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
14.7
12.0
20
18
H02AB02
ATC
dexamethasone; systemic
141.1
11.8
12
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
11.8
11
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
11.8
11
*
UKC05
NOMESCO Finland
Cystoscopy and bladder biopsy
127.3
10.7
11
*
C65
ICD-10 Finland
Malignant neoplasm of renal pelvis
+∞
10.7
10
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
10.7
10
*
JN4BD
NOMESCO Finland
Extensive body CT
12.8
10.2
18
18
B01AB10
ATC
tinzaparin; parenteral
25.8
9.7
13
6
KH1BT
NOMESCO Finland
Urinary tract cathetrisation with X-ray guidance
114.0
9.7
10
*
C67.2
ICD-10 Finland
Malignant neoplasm: Lateral wall of bladder
+∞
9.6
9
*
JN4AD
NOMESCO Finland
Body CT examination
15.3
9.4
15
12
Z51.5
ICD-10 Finland
Palliative care
22.1
9.3
13
7
ZXE20
NOMESCO Finland
More than three and less than five hours
7.5
9.3
23
42
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
42.4
9.3
11
*
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
19.3
8.9
13
8
KH1AD
NOMESCO Finland
CT of urinary organs
23.4
8.8
12
6
A04AA01
ATC
ondansetron; systemic, rectal
31.8
8.8
11
*
WX402
NOMESCO Finland
General anaesthesia
7.5
8.7
21
37
UKA02
NOMESCO Finland
Retrograde ureteronephroscopy
+∞
8.5
8
*
KBD00
NOMESCO Finland
Partial excision of ureter
+∞
8.5
8
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
8.5
8
*
JN4CD
NOMESCO Finland
Very extensive body CT
38.0
8.3
10
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
6.3
8.3
23
49
WX408
NOMESCO Finland
General anesthesy, balanced
4.7
7.9
31
98
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.5
7.6
31
101
ZXE00
NOMESCO Finland
One hour or less
4.1
7.6
40
165
KCD32
NOMESCO Finland
Cystoscopic destruction of tumour of bladder
88.6
7.6
8
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
7.4
7
*
KC1GB
NOMESCO Finland
Cystography with X-ray
+∞
7.4
7
*
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
6.0
7.4
21
46
B01AB05
ATC
enoxaparin; parenteral
4.1
7.3
36
139
WZC30
NOMESCO Finland
Teaching
7.0
7.0
17
30
KBH20
NOMESCO Finland
Replantation of ureter
76.1
6.5
7
*
A03FA01
ATC
metoclopramide; systemic, rectal
5.6
6.5
19
43
XX3DW
NOMESCO Finland
Time consuming IT work
10.0
6.3
12
14
N13.1
ICD-10 Finland
Hydronephrosis with ureteral stricture, not elsewhere classified
+∞
6.3
6
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.6
6.3
37
160
ZXD10
NOMESCO Finland
Scheduled procedure
3.6
6.3
39
176
J01MA12
ATC
levofloxacin; systemic
4.4
6.1
23
68

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_URETER_EXALLC – Malignant neoplasm of ureter, excluding all cancers (controls excluding all cancers)

GWS hits: 1

This endpoint is excluded (different definition than used in FinnGen).