Benign neoplasm: Brain, infratentorial

CD2_BENIGN_BRAIN_INFRATENT

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D33.1
  • Cause of death: ICD-10 D33.1

2 out of 7 registries used, show all original rules.

217

4. Check minimum number of events

None

217

5. Include endpoints

None

217

6. Filter based on genotype QC (FinnGen only)

211

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D33
Name in latin
Neoplasma benignum cerebri infratentoriale

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1554 828 719
Only index persons 1386 743 643
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 44.15 46.77 40.95
Only index persons 43.19 45.75 40.23

-FinnGen-

Key figures

All Female Male
Number of individuals 211 128 83
Unadjusted period prevalence (%) 0.04 0.05 0.04
Median age at first event (years) 48.22 47.09 49.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
217
Matched controls
2170
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
26.9
140.5
134
123
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
280.7
117.8
111
8
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
52.8
78.1
46
11
D33.10
ICD-10 Finland
Benign pilosytic astrocytoma of brain stem
+∞
70.8
64
*
D33.14
ICD-10 Finland
Hemangioblastoma and cerebellum
+∞
61.4
56
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
18.1
51.7
45
31
D33.15
ICD-10 Finland
Another benign tumor of the cerebellum
+∞
51.1
47
*
9161/1-C71.6
ICD-O-3
Hemangioblastoma of cerebellum, NOS
+∞
46.6
43
*
D33.11
ICD-10 Finland
Brain stem
+∞
43.2
40
*
D33.12
ICD-10 Finland
Cerebellum
+∞
37.6
35
*
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
138.3
33.8
35
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
5.8
32.6
80
198
C71.60
ICD-10 Finland
Malignant tumor of cerebellum without histology
+∞
31.0
29
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
6.4
28.6
57
115
D33.1
ICD-10 Finland
Benign neoplasm: Brain, infratentorial
+∞
25.5
24
*
AA1AD
NOMESCO Finland
CT of head and brain
4.3
24.3
98
351
H02AB02
ATC
dexamethasone; systemic
4.8
20.7
56
146
XA800
NOMESCO Finland
Neuropsychological investigation
6.9
19.2
32
53
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
26.6
19.2
26
11
9421/1-C71.6
ICD-O-3
Pilocytic astrocytoma of cerebellum, NOS
+∞
19.0
18
*
G91.1
ICD-10 Finland
Obstructive hydrocephalus
97.7
16.8
18
*
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
+∞
15.8
15
*
H53.2
ICD-10 Finland
Diplopia
7.7
15.6
23
33
D33.17
ICD-10 Finland
Fourth ventricle
+∞
14.7
14
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.4
14.0
66
250
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
148.9
13.6
14
*
XCK00
NOMESCO Finland
Perimetry
5.1
13.3
30
66
WX408
NOMESCO Finland
General anesthesy, balanced
3.0
13.3
84
376
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
26.2
12.7
17
7
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
+∞
12.6
12
*
Q85.82
ICD-10 Finland
of Hipple-Lindau syndrome
+∞
12.6
12
*
ZXE20
NOMESCO Finland
More than three and less than five hours
3.5
12.6
51
174
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
137.6
12.6
13
*
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
22.9
12.2
17
8
AAF00
NOMESCO Finland
Ventriculostomy
49.6
12.0
14
*
R51.80
ICD-10 Finland
Headache
3.1
11.7
63
255
ZXD05
NOMESCO Finland
Urgent procedure
2.7
11.4
88
432
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
19.1
10.9
16
9
G93.0
ICD-10 Finland
Cerebral cysts
63.2
10.7
12
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.6
10.5
39
125
D33.42
ICD-10 Finland
Hemangioblastoma of the spinal cord
+∞
10.5
10
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.8
10.2
65
287
G91.0
ICD-10 Finland
Communicating hydrocephalus
57.6
9.7
11
*
ZXC95
NOMESCO Finland
Use of surgical navigator
22.9
9.5
13
6
D32.05
ICD-10 Finland
Cerebral meninges
+∞
9.4
9
*
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
13.3
9.0
15
12
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.5
9.0
23
56
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
28.8
8.6
11
*
D33.30
ICD-10 Finland
Acoustic neuroma
28.8
8.6
11
*
N76
ICPC
Neoplasm nervous system unspecified
93.5
8.5
9
*
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
+∞
8.4
8
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.1
8.0
23
61
ZXD35
NOMESCO Finland
Usual procedure
6.6
7.7
19
31
TAB00
NOMESCO Finland
Lumbar puncture
4.1
7.7
22
58
WX882
NOMESCO Finland
High dependency care
6.9
7.6
18
28
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
14.0
7.5
12
9
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
14.0
7.5
12
9
9380/3-C71.9
ICD-O-3
Glioma, malignant of brain, NOS
+∞
7.3
7
*
D33.7
ICD-10 Finland
Benign neoplasm: Other specified parts of central nervous system
+∞
7.3
7
*
D32.1
ICD-10 Finland
Benign neoplasm: Spinal meninges
+∞
7.3
7
*
Z98.2
ICD-10 Finland
Presence of cerebrospinal fluid drainage device
+∞
7.3
7
*
D32.06
ICD-10 Finland
Benign tumor of the meninges os petrosum or clivus area
+∞
7.3
7
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
16.5
7.3
11
7
D43.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, unspecified
31.1
7.2
9
*
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
31.1
7.2
9
*
N03AX14
ATC
levetiracetam; systemic
8.0
7.0
15
20
WF002
NOMESCO Finland
Radical radiotherapy
4.4
7.0
18
44
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
6.9
88
519
AA1BD
NOMESCO Finland
Extensive CT of head and brain
7.6
6.8
15
21
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
23.4
6.7
9
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.3
6.7
26
85
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.6
6.5
44
196
Z2445
NOMESCO Finland
Psychologist
3.4
6.5
24
76
9421/1-C71.9
ICD-O-3
Pilocytic astrocytoma of brain, NOS
71.9
6.5
7
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.1
6.4
92
564
R42
ICD-10 Finland
Dizziness and giddiness
2.3
6.3
57
291
C71.69
ICD-10 Finland
Malignant tumor of the cerebellum other or unspecified histology
+∞
6.3
6
*
AAF50
NOMESCO Finland
Third ventriculostomy
+∞
6.3
6
*
C71.6
ICD-10 Finland
Malignant neoplasm: Cerebellum
+∞
6.3
6
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.2
6.0
16
40

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
54
175
3.78
14.56
7.1
11.0
0.65
1.29
mmol/l
0.56
41
144
23
37
6.83
14.05
2.4
2.5
—
—
—
0
0
132
775
2.80
12.20
7.1
7.6
1.20
1.22
mmol/l
1.86
123
713
20
18
12.11
11.31
3.3
1.2
—
—
—
0
0
135
845
2.58
10.30
5.6
8.3
1.21
1.22
mmol/l
1.70
122
735
100
545
2.55
10.24
2.5
2.4
—
—
—
0
0
40
141
3.25
9.24
5.6
10.5
23.91
24.89
mmol/l
1.30
40
141
16
14
12.23
9.23
2.6
3.2
—
—
—
0
0
153
1049
2.55
9.13
6.0
5.5
6.43
6.53
mmol/l
0.25
148
962
41
154
3.05
8.49
1.4
1.4
—
—
—
0
0
20
47
4.59
8.13
2.3
2.2
24.31
3.45
e6/l
0.61
13
38
20
47
4.59
8.13
2.4
2.3
95.69
268.20
e6/l
0.55
13
41
17
22
8.28
8.05
4.2
3.5
1.45
3.21
nmol/l
1.43
17
22
111
716
2.13
6.90
2.4
2.0
—
—
—
0
0
25
81
3.36
6.55
4.3
15.5
—
—
—
0
0
38
160
2.67
6.32
5.4
10.0
—
—
—
0
0
113
756
2.03
6.15
9.6
10.6
1.22
1.21
inr
0.02
27
238
14
24
6.16
5.63
4.1
1.6
—
—
—
0
0
10
10
10.41
5.59
2.2
4.6
58.70
101.70
nmol/l
—
10
10
42
209
2.25
4.84
6.6
8.3
104.98
104.12
mmol/l
0.70
42
209
11
20
5.73
4.35
2.9
3.7
—
—
—
0
0
102
717
1.80
4.30
4.0
5.5
36.81
35.95
g/l
0.87
93
682
78
532
1.73
3.49
3.1
3.0
—
—
—
0
0
10
23
4.50
3.35
3.9
1.6
—
—
nmol/l
—
0
0
202
1825
2.55
3.22
18.4
15.4
3.96
3.96
mmol/l
0.04
197
1765
201
1819
2.42
3.06
18.9
15.3
139.66
139.66
mmol/l
0.00
196
1764
149
1234
1.66
2.99
4.8
4.2
—
—
—
0
0
48
304
1.74
2.73
1.9
1.6
942.22
1228.28
nmol/l
1.26
37
227
85
626
1.59
2.70
2.9
3.7
17.69
38.26
ng/l
1.86
51
406
36
210
1.86
2.68
1.4
1.7
—
—
—
0
0
116
919
1.56
2.68
5.5
7.0
10.28
12.61
umol/l
1.56
106
872
80
590
1.56
2.49
3.7
3.5
2.36
2.36
mmol/l
0.12
64
518
64
451
1.59
2.41
2.0
2.1
3.25
2.97
mg/l
0.42
53
395
27
149
1.93
2.37
3.6
4.0
—
—
—
0
0
85
644
1.53
2.32
4.0
3.7
38.28
64.37
e6/l
0.74
69
445
63
448
1.57
2.27
2.9
3.6
—
—
—
0
0
70
513
1.54
2.20
2.8
4.1
7.38
7.40
ph
—
9
85
44
302
1.57
1.83
3.0
2.8
2.41
2.44
mmol/l
1.92
37
260
46
634
0.65
1.80
2.1
2.6
—
—
—
0
0
42
286
1.58
1.80
2.0
5.4
0.81
0.81
mmol/l
0.04
37
271
67
506
1.47
1.79
3.6
2.9
—
—
—
0
0
13
61
2.20
1.75
13.0
4.5
—
—
—
0
0
15
75
2.07
1.74
1.7
1.5
254.73
340.35
mu/l
0.76
15
68
68
519
1.45
1.71
3.5
3.0
0.18
0.34
e6/l
0.83
58
382
5
132
0.36
1.69
1.2
1.4
—
—
—
0
0
72
559
1.43
1.65
3.4
3.1
26.27
169.24
e6/l
0.65
63
424
22
130
1.77
1.60
2.7
3.4
—
—
—
0
0
58
439
1.44
1.51
3.2
4.2
—
—
—
0
0
68
530
1.41
1.51
2.0
2.5
51.74
54.32
u/l
0.37
61
496
81
655
1.38
1.44
2.3
1.9
99.13
96.96
pmol/l
0.15
50
315
154
1384
1.39
1.38
4.3
3.9
14.62
14.73
pmol/l
0.18
138
1252
40
288
1.48
1.34
3.4
3.0
2.80
2.43
e6/l
0.07
25
146
98
834
1.32
1.21
2.4
2.7
128.67
97.52
ug/l
0.57
88
772
12
207
0.56
1.17
1.8
1.3
—
—
—
0
0
17
103
1.71
1.16
9.8
8.7
—
—
—
0
0
27
185
1.52
1.15
1.4
4.2
2.05
1.74
%
0.63
20
171
47
364
1.37
1.07
2.5
2.8
481.90
547.89
mosm/kgh2o
1.26
42
312
193
1830
1.49
1.05
16.5
13.5
20.88
21.50
mg/l
0.12
171
1435
7
34
2.09
1.04
1.0
1.1
—
—
—
0
0
9
159
0.55
1.03
3.0
3.5
—
—
—
0
0
9
49
1.87
1.00
2.2
3.3
—
—
—
0
0
35
261
1.41
1.00
2.8
2.9
1.01
0.75
ug/l
0.80
22
165
148
1360
1.28
0.91
7.2
7.4
76.88
81.71
u/l
0.85
139
1267
43
339
1.33
0.88
1.7
1.7
447.06
481.64
pmol/l
0.36
34
293
6
33
1.84
0.79
2.3
1.6
—
—
—
0
0
175
1654
1.30
0.78
5.3
4.6
1.67
2.60
mu/l
0.70
160
1510
0
27
0.00
0.78
0.0
1.3
—
—
—
0
0
9
53
1.73
0.76
2.4
2.6
—
—
—
0
0
165
1739
0.79
0.75
4.9
4.6
2.83
2.76
mmol/l
0.48
151
1610
6
107
0.55
0.74
1.5
1.8
—
—
—
0
0
6
106
0.55
0.74
3.0
1.8
—
—
—
0
0
48
395
1.28
0.73
3.6
3.8
1.02
1.02
kg/l
0.06
11
52
197
1898
1.41
0.72
14.6
11.8
—
—
—
0
0
30
232
1.34
0.71
1.3
1.2
—
—
—
0
0
33
411
0.77
0.68
2.0
2.1
0.66
1.21
mg/l
2.20
27
316
32
252
1.32
0.67
2.2
2.1
—
—
—
0
0
106
960
1.20
0.66
4.9
6.5
0.56
0.57
e9/l
0.01
90
832
163
1712
0.81
0.64
4.3
4.2
4.74
4.66
mmol/l
0.48
148
1599
109
992
1.20
0.64
4.9
6.6
1.78
1.90
e9/l
0.80
94
889
6
101
0.58
0.64
2.8
1.9
—
—
—
0
0
6
105
0.56
0.63
3.0
1.8
—
—
—
0
0
6
105
0.56
0.63
3.0
1.9
—
—
—
0
0
9
139
0.63
0.63
1.2
3.5
64.62
66.56
g/l
—
9
131
5
30
1.68
0.62
1.4
1.9
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
4.33
—
0
9
0
21
0.00
0.60
0.0
1.3
—
2.92
—
0
12
162
1699
0.82
0.60
4.3
4.2
1.46
1.49
mmol/l
0.23
148
1576
18
132
1.40
0.59
1.6
3.9
64.84
73.20
e9/l
0.43
12
102
5
86
0.57
0.57
3.0
2.0
—
—
—
0
0
16
116
1.41
0.56
4.1
5.9
—
—
—
0
0
105
961
1.18
0.56
4.9
6.5
0.04
0.04
e9/l
0.44
89
833
79
710
1.18
0.52
3.6
3.4
6.67
5.82
ph
—
6
60
15
110
1.39
0.50
1.2
1.2
—
—
—
0
0
106
983
1.15
0.45
4.9
7.0
0.19
0.18
e9/l
0.16
92
871
36
305
1.22
0.44
3.5
3.7
39.04
132.59
ng/l
1.45
26
233
5
33
1.53
0.41
1.0
9.8
—
—
—
0
0
0
15
0.00
0.41
0.0
3.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.3
—
1.00
—
0
9
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
24
196
1.25
0.41
1.3
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
14.1
—
1362.63
—
0
16
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
2.39
—
0
7
125
1180
1.14
0.40
3.7
3.7
—
—
—
0
0
0
19
0.00
0.39
0.0
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
3.5
—
—
—
0
0
9
67
1.36
0.38
1.0
1.1
—
—
—
0
0
12
91
1.34
0.34
3.8
2.3
—
—
—
0
0
24
201
1.22
0.34
1.2
1.2
—
—
—
0
0
10
132
0.75
0.33
1.3
1.3
178.40
118.02
iu/ml
—
5
53
96
900
1.12
0.32
5.2
6.9
—
—
—
0
0
139
1332
1.12
0.31
4.1
4.0
11.59
10.83
mm/h
0.23
126
1219
29
334
0.85
0.31
1.5
1.6
—
—
—
0
0
39
438
0.87
0.31
1.8
2.8
321.82
7593.12
umol/l
2.24
33
380
8
109
0.72
0.29
1.4
2.8
—
—
—
0
0
14
172
0.80
0.28
1.1
1.4
—
—
—
0
0
10
128
0.77
0.27
1.1
1.5
—
—
—
0
0
8
67
1.20
0.26
2.1
1.8
—
—
—
0
0
18
151
1.21
0.26
3.9
5.0
—
7.41
—
0
13
6
82
0.72
0.24
2.5
3.9
20.67
22.88
s
—
6
75
48
521
0.90
0.23
2.6
3.3
7.74
7.49
mmol/l
0.12
41
443
7
92
0.75
0.23
1.3
1.9
—
—
—
0
0
57
529
1.11
0.23
1.5
1.5
—
—
—
0
0
93
884
1.09
0.23
3.8
3.6
0.00
0.00
estimate
-0.00
14
192
19
163
1.18
0.22
1.1
1.2
—
—
—
0
0
28
249
1.14
0.22
1.9
2.5
2.38
2.42
g/l
0.11
23
228
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
3.1
—
27.00
—
0
11
0
10
0.00
0.21
0.0
4.4
—
1.19
—
0
10
0
10
0.00
0.21
0.0
1.1
—
156.43
—
0
10
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
39
426
0.90
0.21
1.2
1.4
2.26
2.12
g/l
0.30
22
259
116
1117
1.08
0.20
7.0
10.1
4.20
3.95
e9/l
0.55
99
973
0
14
0.00
0.20
0.0
1.2
—
45311.43
—
0
7
0
14
0.00
0.20
0.0
2.6
—
33.29
—
0
14
26
232
1.14
0.19
1.2
1.4
226.67
487.74
titre
—
6
62
44
407
1.10
0.19
4.1
3.7
—
—
—
0
0
7
58
1.21
0.18
1.0
1.3
—
—
—
0
0
7
61
1.15
0.17
1.0
1.2
—
—
—
0
0
83
866
0.93
0.16
6.2
10.1
0.00
0.00
e9/l
0.53
63
689
6
79
0.75
0.16
3.8
2.4
—
—
—
0
0
7
89
0.78
0.15
3.1
3.4
—
—
—
0
0
120
1233
0.94
0.14
3.6
3.2
50.02
42.78
u/l
0.48
111
1166
15
170
0.87
0.14
1.8
1.7
—
—
—
0
0
23
252
0.90
0.13
2.0
1.5
—
—
—
0
0
32
299
1.08
0.11
1.3
1.3
12.35
30.24
iu/ml
2.07
11
105
31
290
1.08
0.11
1.4
1.3
8.81
8.21
u/ml
0.03
14
118
5
47
1.07
0.09
5.6
1.9
—
—
—
0
0
24
224
1.08
0.08
1.3
1.8
—
—
—
0
0
162
1640
0.95
0.08
3.8
3.8
1.29
1.26
mmol/l
0.27
147
1513
5
63
0.79
0.08
1.6
1.7
—
—
—
0
0
44
459
0.95
0.08
3.2
3.8
1.96
8.78
mg/mmol
3.95
27
287
91
890
1.04
0.07
5.7
4.9
0.00
0.00
estimate
-0.00
13
183
26
247
1.06
0.06
1.3
1.6
—
—
—
0
0
170
1685
1.04
0.05
4.4
4.1
5.61
5.84
mmol/l
2.00
156
1544
21
221
0.94
0.04
1.2
1.5
—
—
—
0
0
16
151
1.06
0.03
1.3
1.5
—
—
—
0
0
40
390
1.03
0.03
1.8
2.0
—
—
—
0
0
50
491
1.02
0.02
5.5
8.2
—
—
—
0
0
204
2033
1.06
0.01
24.3
19.8
262.40
252.57
e9/l
1.40
198
1980
204
2033
1.06
0.01
24.4
20.0
40.05
40.17
%
0.13
189
1933
48
488
0.98
0.01
3.7
3.9
0.00
0.00
estimate
-0.00
12
177
14
147
0.95
0.01
3.4
2.7
8.71
10.02
g/l
1.06
14
136
51
516
0.98
0.00
3.1
3.1
—
—
—
0
0
46
461
1.00
0.00
1.2
1.3
5.55
1.37
u/ml
0.46
12
120
158
1578
1.00
0.00
22.3
17.8
333.49
332.57
g/l
0.69
158
1570
90
903
0.99
0.00
4.2
3.7
0.00
0.00
estimate
-0.00
13
177
44
438
1.01
0.00
2.4
3.2
20.83
349.83
mg/l
0.95
26
278
204
2035
1.04
0.00
24.3
19.8
6.92
6.62
e9/l
1.41
198
1977
204
2035
1.04
0.00
24.2
19.8
4.51
4.50
e12/l
0.08
198
1978
192
1922
0.99
0.00
10.3
10.1
25.86
25.59
u/l
0.10
185
1858
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
0.55
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
159.33
—
0
8
0
7
0.00
-0.00
0.0
1.1
—
75.86
—
0
7
7
79
0.88
-0.00
1.1
1.2
—
—
—
0
0
158
1580
1.00
-0.00
5.5
5.2
37.28
39.27
mmol/mol
2.59
146
1484
0
6
0.00
-0.00
0.0
1.3
—
1.20
—
0
6
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
8.6
—
—
—
0
0
9
98
0.91
-0.00
1.7
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
33.2
—
0.61
—
0
5
0
8
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
4.26
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.4
—
49.71
—
0
7
13
130
1.00
-0.00
3.9
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
89
0.90
-0.00
5.0
5.8
9.79
8.76
kpa
—
8
84
0
6
0.00
-0.00
0.0
1.2
—
136.33
—
0
6
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
7
69
1.01
-0.00
8.3
9.1
1.11
1.36
mg/l
—
7
64
6
61
0.98
-0.00
10.5
9.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
8.2
—
24.72
—
0
6
7
77
0.91
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
68
0.88
-0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
11.8
—
1.14
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_BRAIN_INFRATENT and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_BRAIN_INFRATENT 1.861 [1.47, 2.35] < 0.001
Birth year 0.994 [0.99, 1.0] 0.201

During the follow-up period (1.1.1998 — 31.12.2019), 125 out of 692 females with CD2_BENIGN_BRAIN_INFRATENT died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_BRAIN_INFRATENT 2.417 [1.8, 3.24] < 0.001
Birth year 0.992 [0.98, 1.0] 0.089

During the follow-up period (1.1.1998 — 31.12.2019), 122 out of 603 males with CD2_BENIGN_BRAIN_INFRATENT died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_BRAIN_INFRATENT.

N-year risk Females Males
1 0.215% 0.496%
5 1.161% 3.052%
10 2.919% 7.476%
15 5.319% 14.591%
20 9.131% 24.239%

Relationships between endpoints

Index endpoint: CD2_BENIGN_BRAIN_INFRATENT – Benign neoplasm: Brain, infratentorial

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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