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Crystalline deposits in vitreous body

DOID EFO Endpoint Browser PheWeb

H7_VITRCRYSTAL

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H43.2
  • Cause of death: ICD-10 — H43.2

2 out of 7 registries used, show all original rules.

319

4. Check minimum number of events

None

319

5. Include endpoints

None

319

6. Filter based on genotype QC (FinnGen only)

308

Control definitions (FinnGen only)

Control exclude
H7_VITREOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H43
Name in latin
Depositiones crystallinae corporis vitrei

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1754 700 1049
Only index persons 1640 667 973
Unadjusted period prevalence (%)
Whole population 0.03 0.02 0.03
Only index persons 0.03 0.02 0.04
Median age at first event (years)
Whole population 71.12 69.89 71.95
Only index persons 70.79 69.70 71.54

-FinnGen-

Key figures

All Female Male
Number of individuals 308 121 187
Unadjusted period prevalence (%) 0.07 0.04 0.09
Median age at first event (years) 68.33 64.48 70.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
319
Matched controls
3190
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H43.2
ICD-10 Finland
Crystalline deposits in vitreous body
+∞
307.7
319
*
H43.8
ICD-10 Finland
Other disorders of vitreous body
29.4
75.3
52
21
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
17.4
46.8
40
26
H43.3
ICD-10 Finland
Other vitreous opacities
96.5
38.8
42
5
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.7
36.9
115
339
WX140
NOMESCO Finland
Parabulbar anesthesy
6.4
25.6
46
82
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.0
19.4
64
189
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.0
19.4
63
184
H26.4
ICD-10 Finland
After-cataract
3.8
16.5
58
178
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.6
15.6
167
950
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.7
15.6
118
567
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
4.9
14.4
33
73
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.4
14.3
38
95
103
Kela drug reimbursment
Diabetes, insulin-treated
2.5
13.9
129
677
H25.8
ICD-10 Finland
Other senile cataract
3.1
13.7
68
258
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.4
12.6
49
160
H25.0
ICD-10 Finland
Senile incipient cataract
3.6
11.7
41
125
A10AB01
ATC
insulin (human); parenteral
5.2
11.4
24
49
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
5.4
11.0
22
43
A10AA02, ,
ATC
4.9
10.7
24
52
H43.1
ICD-10 Finland
Vitreous haemorrhage
113.6
10.5
11
*
SPAT1262
SPAT
Handing over of treatment supplies
2.5
10.4
80
378
A10AE04
ATC
insulin glargine; parenteral
2.9
10.1
52
200
A10AB04
ATC
insulin lispro; parenteral
5.4
9.5
19
37
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.1
9.2
144
904
A10AA01, ,
ATC
7.8
9.1
20
27
T90
ICPC
Diabetes non-insulin dependent
2.2
8.9
104
584
M10
ICD-10 Finland
Gout
4.0
8.8
26
70
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.6
8.7
18
22
H25.1
ICD-10 Finland
Senile nuclear cataract
2.0
8.6
131
811
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.4
8.5
71
345
H36.00
ICD-10 Finland
Diabetic background retinopathy
9.3
8.1
16
18
H53.9
ICD-10 Finland
Visual disturbance, unspecified
4.3
8.1
21
51
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
7.6
8.1
18
25
CKC12
NOMESCO Finland
Photocoagulation of retina
4.4
7.9
20
48
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
7.7
7.8
17
23
XCK10
NOMESCO Finland
Photography of fundus of eye
2.6
7.7
46
191
T89
ICPC
Diabetes insulin dependent
3.9
7.2
21
56
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
30.8
7.2
9
*
H3600, E103,
ICD-10 Finland
20.6
7.2
10
5
M10.9
ICD-10 Finland
Gout, unspecified
2.8
6.9
35
133
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
3.0
6.9
32
116
A10AE05
ATC
insulin detemir; parenteral
3.2
6.8
28
94
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
4.4
6.8
17
40
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
3.4
6.6
24
75
SAA01
NOMESCO Finland
Simple examination of mouth
1.9
6.6
203
1543
C10AX09
ATC
ezetimibe; oral
2.1
6.5
67
353
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.0
6.4
18
47
H43.9
ICD-10 Finland
Disorder of vitreous body, unspecified
+∞
6.3
6
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.9
6.3
102
633
A10BA02
ATC
metformin; oral
1.9
6.2
113
725
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.2
6.1
57
288

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
145
883
2.18
10.35
4.8
3.9
9.48
9.86
mg/mmol
0.04
91
551
139
853
2.12
9.53
3.9
3.2
6.95
7.30
mmol/l
0.43
109
691
136
828
2.12
9.52
4.1
3.4
589.51
343.63
mg/l
0.20
84
540
80
464
1.97
5.96
1.4
1.2
0.67
1.32
u/ml
0.75
20
116
156
1116
1.78
5.95
5.5
4.0
39.08
67.50
ng/l
0.42
130
845
110
712
1.83
5.85
3.8
3.0
379.53
8676.17
umol/l
3.51
89
607
231
1868
1.86
5.70
4.7
4.3
14.94
13.77
mm/h
0.50
209
1696
90
558
1.85
5.44
1.8
1.7
1112.21
1190.04
nmol/l
0.35
66
421
202
1582
1.75
5.41
9.9
5.0
7.21
6.86
mmol/l
1.52
192
1480
170
1269
1.73
5.41
6.0
4.0
0.00
0.01
estimate
0.50
30
218
119
806
1.76
5.35
4.8
3.5
—
—
—
0
0
123
842
1.75
5.32
2.9
2.5
67.42
62.77
u/l
0.25
116
775
122
837
1.74
5.21
4.5
4.3
—
—
—
0
0
266
2277
2.01
5.19
5.8
4.5
1.93
2.56
mu/l
0.60
238
2011
166
1245
1.69
5.08
8.4
5.5
0.00
0.00
estimate
-0.00
34
231
244
2037
1.84
5.06
8.5
8.1
79.19
80.57
u/l
0.19
232
1887
165
1238
1.69
5.03
6.0
4.0
0.03
0.00
estimate
0.39
38
252
73
433
1.89
5.03
1.7
1.4
2.40
2.65
g/l
0.46
44
252
94
616
1.75
4.64
2.1
1.7
442.71
418.93
pmol/l
0.38
70
506
47
247
2.06
4.56
3.2
3.1
64.67
66.12
g/l
0.51
42
224
291
2607
2.32
4.55
25.2
19.9
138.91
139.59
mmol/l
3.72
286
2532
282
2501
2.10
4.44
6.1
5.4
2.46
2.61
mmol/l
1.99
253
2258
291
2612
2.30
4.44
25.1
20.0
4.03
4.01
mmol/l
0.48
286
2538
135
985
1.64
4.42
5.3
3.8
5.90
5.80
ph
—
5
58
287
2564
2.19
4.40
23.0
15.8
—
—
—
0
0
217
1788
1.67
4.31
6.7
4.6
—
—
—
0
0
118
837
1.65
4.29
1.9
2.1
129.96
246.68
u/l
2.58
112
784
291
2622
2.25
4.23
25.0
20.0
84.95
82.51
umol/l
0.72
291
2622
31
143
2.29
4.15
3.1
2.6
0.79
0.67
%
1.60
31
143
20
75
2.78
4.07
1.6
1.5
242.74
272.96
ug/g
0.30
13
44
217
1810
1.62
3.89
4.7
3.6
15.09
14.99
pmol/l
0.21
193
1595
291
2640
2.17
3.85
12.9
11.5
24.91
25.14
u/l
0.10
280
2529
172
1364
1.57
3.79
7.0
6.9
1.21
1.21
mmol/l
0.11
142
1161
31
149
2.20
3.77
3.1
2.7
1.37
1.17
%
0.58
31
149
268
2371
1.82
3.76
9.1
6.4
43.90
40.80
mmol/mol
3.86
241
2165
277
2476
1.90
3.75
21.5
16.7
30.45
26.33
mg/l
1.03
239
2017
274
2441
1.87
3.74
5.5
4.8
4.34
4.48
mmol/l
1.36
244
2218
39
206
2.02
3.73
3.3
2.8
—
—
—
0
0
14
45
3.21
3.69
3.5
2.8
—
—
—
0
0
272
2423
1.83
3.64
5.6
4.7
1.43
1.43
mmol/l
0.08
241
2180
12
30
4.11
3.63
4.4
2.9
—
—
—
0
0
274
2450
1.84
3.57
5.9
5.0
6.42
6.09
mmol/l
3.25
244
2194
14
46
3.14
3.57
3.5
2.8
4.04
4.07
mmol/l
0.12
14
46
14
46
3.14
3.57
3.5
2.8
104.00
105.57
mmol/l
0.49
14
46
97
682
1.61
3.55
5.8
4.3
0.00
0.00
estimate
-0.00
29
222
31
153
2.14
3.54
1.2
1.2
—
—
—
0
0
296
2718
2.23
3.54
30.7
24.4
91.40
91.62
fl
0.37
291
2669
296
2718
2.23
3.54
30.9
24.5
240.86
241.18
e9/l
0.03
289
2643
296
2719
2.23
3.52
30.8
24.6
39.36
39.72
%
0.34
269
2523
296
2719
2.23
3.52
30.9
24.5
4.40
4.44
e12/l
0.74
290
2634
296
2719
2.23
3.52
30.9
24.5
7.08
6.86
e9/l
0.94
290
2632
296
2719
2.23
3.52
30.6
24.4
30.44
30.46
pg
0.07
291
2670
296
2720
2.22
3.50
31.1
24.6
133.09
134.30
g/l
0.62
291
2668
265
2352
1.75
3.47
4.9
4.2
1.37
1.28
mmol/l
1.45
232
2101
21
88
2.48
3.47
7.6
5.2
—
—
—
0
0
155
1218
1.53
3.45
4.2
4.7
34.39
35.12
g/l
0.81
140
1139
30
149
2.12
3.38
6.9
4.2
—
—
—
0
0
22
97
2.36
3.28
3.5
4.0
35.78
38.82
mg/l
0.10
17
78
22
97
2.36
3.28
3.5
4.0
37.51
139.17
mg/l
0.86
16
77
127
966
1.52
3.24
3.7
3.2
1064.09
1408.01
ng/l
0.92
109
843
80
548
1.61
3.22
5.7
4.5
1.01
1.02
kg/l
0.79
11
78
35
188
1.97
3.21
4.8
3.6
7.43
7.40
ph
—
5
22
145
1136
1.51
3.20
2.4
2.1
100.00
94.25
pmol/l
0.71
73
602
12
35
3.52
3.14
3.2
2.7
1.04
2.03
g/24h
—
6
19
172
1400
1.50
3.13
19.6
15.8
1.29
1.34
inr
0.30
54
392
22
100
2.29
3.07
2.6
1.8
—
—
—
0
0
40
229
1.85
3.05
3.8
3.5
—
—
—
0
0
186
1549
1.48
2.96
3.7
3.2
59.67
54.39
u/l
0.28
169
1429
62
411
1.63
2.83
2.3
2.0
—
—
—
0
0
25
125
2.09
2.79
1.2
1.2
—
—
—
0
0
112
851
1.49
2.79
6.0
4.3
—
—
—
0
0
5
6
8.44
2.76
1.2
1.7
—
—
—
0
0
16
67
2.46
2.67
3.8
4.3
—
—
—
0
0
174
1451
1.44
2.62
6.6
6.7
10.03
11.71
umol/l
2.39
167
1377
17
75
2.34
2.55
6.7
11.2
—
—
—
0
0
95
712
1.48
2.50
1.7
1.6
24.96
20.20
nmol/l
1.61
76
592
39
239
1.72
2.39
3.5
3.0
4.47
4.38
kpa
0.16
39
227
147
1204
1.41
2.37
4.9
6.2
26.71
26.37
%
0.14
134
1121
79
578
1.49
2.33
5.4
3.1
547.42
561.88
mosm/kgh2o
0.20
71
483
14
59
2.44
2.32
3.9
4.1
—
—
—
0
0
144
1183
1.40
2.25
4.7
5.9
57.94
58.20
%
0.08
131
1104
39
244
1.68
2.23
2.8
2.0
357.33
379.50
nmol/l
0.29
33
223
10
35
2.92
2.23
1.8
1.3
—
—
—
0
0
34
206
1.73
2.18
3.5
4.1
—
—
—
0
0
152
1265
1.39
2.18
6.7
6.0
1.21
1.21
mmol/l
0.12
133
1133
23
123
1.94
2.18
1.7
1.3
—
—
—
0
0
147
1217
1.39
2.17
2.8
2.7
—
—
—
0
0
143
1179
1.39
2.17
5.0
6.3
9.08
8.86
%
0.23
129
1099
142
1171
1.38
2.14
5.5
6.5
—
—
—
0
0
142
1173
1.38
2.11
4.6
5.9
2.86
2.85
%
0.02
128
1091
52
355
1.56
2.11
1.4
1.3
20.63
8.71
u/ml
0.26
18
136
43
281
1.61
2.09
4.0
3.8
1.96
1.94
mmol/l
0.02
38
224
139
1146
1.38
2.08
4.6
5.9
0.64
0.63
%
0.14
125
1070
43
282
1.61
2.06
4.9
4.2
—
—
—
0
0
43
283
1.60
2.03
4.0
3.7
5.67
5.74
kpa
0.20
43
272
40
259
1.62
2.02
1.9
2.9
65.04
69.71
e9/l
0.66
32
202
6
16
3.80
1.94
1.8
1.3
—
—
—
0
0
144
1207
1.35
1.90
5.4
5.4
2.83
2.81
ug/l
0.01
127
1065
108
866
1.37
1.89
4.8
3.4
580.39
138.53
e6/l
0.35
89
662
51
357
1.51
1.85
1.3
1.3
—
—
—
0
0
19
104
1.88
1.71
2.5
3.7
0.32
0.21
g/l
—
9
41
33
213
1.61
1.70
3.3
3.8
1.23
1.22
mmol/l
0.38
28
189
147
1251
1.32
1.70
4.6
5.6
0.04
0.04
e9/l
0.51
127
1088
86
681
1.36
1.60
7.3
3.7
—
—
—
0
0
52
379
1.44
1.56
1.4
1.3
26.57
37.18
iu/ml
0.51
17
122
117
975
1.32
1.54
5.5
4.0
88.22
91.27
e6/l
0.02
93
704
148
1274
1.30
1.53
4.8
5.8
1.77
1.84
e9/l
0.42
129
1137
23
139
1.71
1.53
5.6
3.7
—
—
—
0
0
44
312
1.48
1.52
3.0
1.6
—
—
—
0
0
145
1248
1.30
1.49
4.7
5.6
0.62
0.61
e9/l
0.05
127
1079
9
37
2.47
1.49
2.3
2.6
—
—
—
0
0
22
133
1.70
1.47
2.7
2.4
—
—
—
0
0
14
73
1.96
1.46
1.1
1.6
—
—
—
0
0
149
1290
1.29
1.46
4.8
5.9
0.19
0.20
e9/l
0.28
130
1140
20
118
1.74
1.45
5.9
3.9
—
—
—
0
0
13
67
1.98
1.40
4.2
2.5
—
—
—
0
0
27
176
1.58
1.37
3.9
3.3
5.05
5.83
e9/l
0.18
19
139
72
572
1.33
1.31
4.7
4.1
—
—
—
0
0
167
1482
1.27
1.29
7.9
9.6
4.43
4.25
e9/l
0.37
148
1304
5
18
2.80
1.29
1.2
1.8
37.60
31.86
%
—
5
18
104
873
1.28
1.26
2.5
2.4
—
—
—
0
0
95
791
1.29
1.23
4.8
3.2
0.28
0.55
e6/l
1.03
79
589
8
38
2.13
1.19
1.1
1.1
—
—
—
0
0
6
26
2.33
1.19
10.7
1.6
—
—
—
0
0
40
294
1.41
1.17
1.5
1.3
—
—
—
0
0
31
217
1.47
1.17
2.7
2.2
266.19
147.07
ug/g
0.41
21
180
110
939
1.26
1.16
2.4
3.6
2.34
2.34
mmol/l
0.22
89
819
5
20
2.52
1.15
2.4
1.3
—
—
—
0
0
14
80
1.78
1.15
2.9
2.5
296.51
81.97
ug/min
—
7
40
7
30
2.36
1.13
1.6
1.2
—
—
—
0
0
5
21
2.40
1.09
1.0
1.1
—
—
—
0
0
5
21
2.40
1.09
1.0
1.1
—
—
—
0
0
5
21
2.40
1.09
1.4
1.2
—
—
—
0
0
30
212
1.46
1.09
2.4
4.2
0.43
1.10
%
—
7
96
19
121
1.61
1.08
1.4
3.4
4.18
4.41
pmol/l
0.43
19
108
97
826
1.25
1.03
4.7
4.2
7.40
7.40
ph
0.13
18
152
7
35
2.02
1.00
9.0
1.4
—
—
—
0
0
7
35
2.02
1.00
9.3
1.4
—
—
—
0
0
85
715
1.26
1.00
2.9
2.1
2.89
3.16
mg/l
0.61
72
612
67
548
1.28
0.99
1.5
1.7
1.57
1.41
mg/l
0.09
49
440
16
245
0.63
0.98
3.3
2.4
26.06
33.52
u/l
1.08
16
200
7
36
1.97
0.97
10.0
1.4
—
—
—
0
0
7
36
1.97
0.97
9.4
1.4
—
—
—
0
0
42
323
1.35
0.96
2.9
4.6
21.80
43.53
ug/l
0.31
34
270
32
236
1.40
0.94
1.4
1.6
—
—
—
0
0
27
193
1.44
0.94
6.8
5.9
25.26
24.45
mmol/l
0.74
27
185
6
28
2.16
0.92
1.2
2.6
—
—
—
0
0
53
425
1.30
0.92
2.4
2.3
2.37
2.27
g/l
0.59
45
389
10
56
1.81
0.89
2.7
2.5
—
—
—
0
0
51
410
1.29
0.87
2.4
2.3
19.58
22.04
%
0.97
40
351
29
215
1.38
0.84
6.7
3.8
—
—
—
0
0
6
32
1.89
0.82
9.2
1.4
—
—
—
0
0
21
148
1.45
0.80
2.5
2.9
—
—
—
0
0
7
122
0.56
0.79
1.1
1.5
—
—
—
0
0
81
698
1.22
0.77
1.9
1.6
1.47
1.32
mmol/l
0.71
58
570
40
318
1.29
0.75
1.6
1.4
—
—
—
0
0
5
25
2.02
0.73
9.8
1.2
—
—
—
0
0
7
39
1.81
0.73
2.1
3.6
—
—
—
0
0
12
76
1.60
0.72
1.7
1.5
—
—
—
0
0
86
751
1.20
0.71
4.8
3.2
—
—
—
0
0
5
26
1.94
0.71
1.0
1.1
—
—
—
0
0
115
1032
1.18
0.70
3.3
2.6
119.42
146.69
ug/l
0.86
100
937
25
188
1.36
0.69
6.0
3.0
—
—
—
0
0
5
27
1.86
0.68
1.2
1.9
1.87
0.97
e9/l
—
5
22
5
27
1.86
0.68
1.0
1.4
—
—
—
0
0
42
344
1.25
0.64
1.8
2.7
1.69
1.81
%
0.39
32
309
5
29
1.74
0.64
1.0
1.4
0.54
0.55
nmol/l
—
5
24
43
355
1.24
0.62
4.7
6.6
1.42
1.40
mmol/l
0.01
37
289
0
20
0.00
0.60
0.0
3.3
—
—
—
0
0
211
2001
1.16
0.60
25.7
22.2
332.67
331.85
g/l
0.73
211
1986
8
53
1.52
0.59
1.1
1.4
—
—
—
0
0
85
755
1.17
0.58
4.1
3.2
—
—
—
0
0
6
36
1.68
0.57
1.7
2.1
33.50
32.92
pg
—
6
36
10
65
1.56
0.56
1.8
1.2
—
—
—
0
0
10
147
0.67
0.55
1.4
1.4
—
—
—
0
0
11
74
1.50
0.54
1.2
1.1
—
—
—
0
0
6
39
1.55
0.53
2.0
1.8
—
—
—
0
0
6
39
1.55
0.53
1.2
2.0
82.88
88.75
%
—
6
39
7
46
1.53
0.48
4.0
2.9
—
—
—
0
0
62
547
1.17
0.47
5.5
3.8
138.24
318.18
ng/l
1.02
47
456
54
474
1.17
0.44
2.6
2.3
10.96
12.46
umol/l
1.07
47
434
0
16
0.00
0.41
0.0
1.5
—
0.15
—
0
9
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
1.80
—
0
17
0
17
0.00
0.41
0.0
1.2
—
0.10
—
0
12
5
34
1.48
0.40
1.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
24
197
1.24
0.39
1.5
1.3
—
—
—
0
0
6
41
1.47
0.36
1.3
1.2
11.53
9.36
u/l
—
6
32
6
42
1.44
0.35
1.5
2.4
—
—
—
0
0
34
293
1.18
0.35
5.5
7.2
116.65
120.53
g/l
0.59
34
288
6
43
1.40
0.35
1.0
1.6
—
—
—
0
0
10
73
1.38
0.35
1.7
2.2
13.79
12.60
mg/l
—
10
67
6
90
0.66
0.33
5.0
6.4
1.10
1.36
mmol/l
—
6
80
13
161
0.80
0.28
8.0
9.1
—
—
—
0
0
68
628
1.11
0.27
1.4
1.3
—
—
—
0
0
14
113
1.25
0.27
1.4
2.1
156.86
322.98
ug/l
1.35
14
105
9
75
1.21
0.25
1.0
1.1
—
—
—
0
0
28
247
1.15
0.23
1.5
1.4
—
—
—
0
0
28
248
1.14
0.22
5.5
7.6
—
—
—
0
0
0
10
0.00
0.21
0.0
4.6
—
56.80
—
0
10
0
10
0.00
0.21
0.0
1.1
—
0.18
—
0
5
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
6
53
1.13
0.19
1.3
1.5
—
—
—
0
0
7
61
1.15
0.17
1.0
1.1
—
—
—
0
0
32
292
1.11
0.17
1.1
1.7
—
—
—
0
0
5
66
0.75
0.17
1.2
3.0
—
—
—
0
0
13
111
1.18
0.16
1.2
1.3
—
—
—
0
0
50
470
1.08
0.15
5.0
3.2
1.48
1.88
e6/l
0.28
34
261
115
1112
1.05
0.15
12.4
10.1
0.00
0.00
e9/l
0.44
101
913
63
662
0.94
0.14
8.6
6.8
—
—
—
0
0
27
248
1.10
0.13
1.2
1.5
—
—
—
0
0
32
344
0.92
0.13
1.2
1.3
—
—
—
0
0
5
44
1.14
0.10
3.6
3.2
57.80
58.50
%
—
5
44
22
203
1.09
0.10
1.6
1.5
—
—
—
0
0
5
45
1.11
0.10
1.2
1.4
—
—
—
0
0
5
46
1.09
0.09
1.8
1.6
54.14
314.24
pmol/l
—
5
46
11
97
1.14
0.09
1.1
1.7
—
—
—
0
0
6
56
1.07
0.08
1.3
1.4
—
—
—
0
0
187
1844
1.03
0.08
5.0
4.3
—
—
—
0
0
5
61
0.82
0.08
1.0
1.2
—
—
—
0
0
5
65
0.77
0.08
5.4
6.8
105.60
104.70
mmol/l
—
5
60
5
65
0.77
0.08
5.4
6.8
11.20
11.17
mmol/l
—
5
60
6
75
0.80
0.07
1.7
1.4
166769.17
20000.81
e6/l
—
6
58
8
78
1.03
0.07
5.8
4.9
7.38
7.42
ph
—
8
68
8
78
1.03
0.07
1.4
1.3
—
3.34
—
0
8
7
84
0.83
0.07
1.4
2.4
20.71
21.99
s
—
7
77
11
118
0.93
0.03
1.2
1.3
—
—
—
0
0
105
1040
1.01
0.02
2.6
2.2
—
—
—
0
0
29
298
0.97
0.02
1.5
1.3
194.29
515.14
titre
—
7
74
17
164
1.04
0.00
5.0
8.9
24.56
24.85
mmol/l
0.22
17
157
56
554
1.01
0.00
2.0
3.1
2.45
2.45
mmol/l
0.15
44
491
68
686
0.99
0.00
2.8
3.2
0.82
0.79
ug/l
0.11
48
483
23
232
0.99
0.00
1.2
1.5
—
—
—
0
0
27
272
0.99
0.00
3.3
2.5
3.99
8.10
ug/l
1.79
20
237
5
56
0.89
0.00
1.6
1.6
—
—
—
0
0
6
59
1.02
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
37.50
—
0
6
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
21.50
—
0
8
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
10.1
—
833.50
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
14.90
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
13.2
—
1704.37
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
57.00
—
0
5
8
81
0.99
-0.00
4.2
3.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.3
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_VITRCRYSTAL and mortality.

Females

Parameter HR [95% CI] p-value
H7_VITRCRYSTAL 0.983 [0.8, 1.21] 0.868
Birth year 0.996 [0.99, 1.0] 0.342

During the follow-up period (1.1.1998 — 31.12.2019), 133 out of 603 females with H7_VITRCRYSTAL died.

Males

Parameter HR [95% CI] p-value
H7_VITRCRYSTAL 0.981 [0.8, 1.2] 0.852
Birth year 0.989 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 251 out of 834 males with H7_VITRCRYSTAL died.

Mortality risk

Mortality risk for people of age

years, who have H7_VITRCRYSTAL.

N-year risk Females Males
1 0.063% 0.173%
5 0.566% 1.147%
10 1.412% 2.925%
15 2.787% 5.421%
20 4.935% 9.54%

Relationships between endpoints

↥

Index endpoint: H7_VITRCRYSTAL – Crystalline deposits in vitreous body

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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