Crystalline deposits in vitreous body

H7_VITRCRYSTAL

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H43.2
  • Cause of death: ICD-10 H43.2

2 out of 7 registries used, show all original rules.

301

4. Check minimum number of events

None

301

5. Include endpoints

None

301

6. Filter based on genotype QC (FinnGen only)

301

Control definitions (FinnGen only)

Control exclude
H7_VITREOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H43
Name in latin
Depositiones crystallinae corporis vitrei

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1754 700 1049
Only index persons 1640 667 973
Unadjusted period prevalence (%)
Whole population 0.03 0.02 0.03
Only index persons 0.03 0.02 0.04
Median age at first event (years)
Whole population 71.12 69.89 71.95
Only index persons 70.79 69.70 71.54

-FinnGen-

Key figures

All Female Male
Number of individuals 301 121 180
Unadjusted period prevalence (%) 0.06 0.04 0.08
Median age at first event (years) 68.20 64.48 70.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
264
Matched controls
2639
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H43.2
ICD-10 Finland
Crystalline deposits in vitreous body
+∞
323.0
264
*
H43.3
ICD-10 Finland
Other vitreous opacities
234.6
40.0
40
*
H43.8
ICD-10 Finland
Other disorders of vitreous body
56.9
33.6
39
8
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.8
29.2
97
240
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
17.5
21.7
34
22
WX140
NOMESCO Finland
Parabulbar anesthesy
7.9
16.4
38
55
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.5
16.0
50
108
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.7
13.0
135
743
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.6
11.4
55
180
A10AA01
ATC
NA
13.5
11.3
19
15
H26.4
ICD-10 Finland
After-cataract
3.8
11.2
49
148
A10AA02
ATC
NA
8.6
10.9
23
29
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
8.0
10.4
23
31
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
7.2
10.2
24
36
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
15.4
10.1
16
11
H25.1
ICD-10 Finland
Senile nuclear cataract
2.4
9.8
107
578
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
10.6
9.7
18
18
A10AE04
ATC
insulin glargine; parenteral
3.7
9.7
43
131
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.3
9.2
122
724
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.6
9.0
42
133
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
14.7
8.8
14
10
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
9.5
8.7
17
19
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.4
8.5
89
467
H43.1
ICD-10 Finland
Vitreous haemorrhage
92.9
8.5
9
*
103
Kela drug reimbursment
Diabetes, insulin-treated
2.3
8.4
100
556
H36.00
ICD-10 Finland
Diabetic background retinopathy
12.2
8.2
14
12
H25.8
ICD-10 Finland
Other senile cataract
2.8
8.2
56
231
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
7.5
7.6
17
24
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
5.1
7.0
21
44
H3600, E103
ICD-10 Finland
NA
23.2
6.7
9
*
H53.9
ICD-10 Finland
Visual disturbance, unspecified
7.2
6.6
15
22
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.5
6.6
30
94
H25.0
ICD-10 Finland
Senile incipient cataract
3.2
6.5
33
113
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.5
6.4
52
237
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
18.6
6.3
9
5
AA1AD
NOMESCO Finland
CT of head and brain
2.1
6.3
79
442
T89
ICPC
Diabetes insulin dependent
5.6
6.3
17
32
CKC12
NOMESCO Finland
Photocoagulation of retina
5.6
6.3
17
32
H52.1
ICD-10 Finland
Myopia
7.0
6.1
14
21
SPAT1262
SPAT
Handing over of treatment supplies
2.2
6.1
67
353

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
135
830
2.14
9.31
5.2
4.1
9.8
10.0
mg/mmol
0.01
83
517
126
777
2.07
8.42
4.2
3.3
656.6
283.8
mg/l
0.29
75
500
128
801
2.04
8.16
3.9
3.2
6.8
7.4
mmol/l
0.66
99
643
88
527
1.95
6.04
1.9
1.7
1108.7
1178.6
nmol/l
0.30
65
397
252
2127
2.13
5.66
5.8
4.5
1.9
2.6
mu/l
0.60
227
1872
162
1192
1.78
5.63
6.0
4.1
0.0
0.0
estimate
0.50
26
206
113
755
1.80
5.41
4.9
3.5
—
—
—
0
0
75
443
1.92
5.29
1.4
1.2
0.7
1.4
u/ml
0.76
18
110
116
787
1.77
5.24
2.8
2.5
63.8
56.9
u/l
0.88
109
720
157
1161
1.74
5.23
5.9
4.1
0.0
0.0
estimate
0.00
27
220
158
1172
1.73
5.19
8.3
5.6
0.0
0.0
estimate
0.00
30
219
189
1479
1.75
5.08
10.3
5.1
7.3
6.9
mmol/l
1.60
180
1383
70
410
1.92
5.05
1.7
1.4
2.4
2.7
g/l
0.57
42
240
91
581
1.81
5.01
2.0
1.8
443.1
419.1
pmol/l
0.38
68
474
101
669
1.77
4.89
4.0
3.0
383.5
9262.8
umol/l
3.51
81
567
230
1916
1.85
4.88
8.7
8.1
79.2
80.9
u/l
0.23
217
1771
114
786
1.72
4.78
1.9
2.1
131.3
250.1
u/l
2.43
108
737
144
1059
1.69
4.75
5.6
4.1
40.9
69.8
ng/l
0.40
120
800
214
1754
1.76
4.69
4.8
4.3
15.1
13.8
mm/h
0.50
193
1590
271
2407
2.26
4.49
23.2
16.0
—
—
—
0
0
274
2447
2.33
4.44
25.8
20.0
138.9
139.6
mmol/l
3.93
269
2375
207
1697
1.70
4.36
4.6
3.7
15.1
14.9
pmol/l
0.41
183
1490
274
2452
2.31
4.33
25.7
20.2
4.0
4.0
mmol/l
0.45
269
2381
204
1673
1.68
4.22
6.7
4.6
—
—
—
0
0
274
2461
2.26
4.13
25.5
20.2
85.3
82.7
umol/l
0.77
274
2461
264
2345
2.02
4.00
6.1
5.4
2.4
2.6
mmol/l
2.24
237
2113
164
1284
1.61
3.99
7.2
7.0
1.2
1.2
mmol/l
0.20
134
1082
253
2222
1.87
3.89
9.1
6.5
43.8
40.9
mmol/mol
3.13
228
2031
30
141
2.25
3.86
3.1
2.8
1.4
1.1
%
0.71
30
141
111
796
1.62
3.84
4.7
4.4
—
—
—
0
0
38
197
2.06
3.84
3.4
2.8
—
—
—
0
0
11
29
3.90
3.84
4.7
2.8
—
—
—
0
0
148
1143
1.58
3.73
4.3
4.6
34.3
35.0
g/l
0.73
134
1064
22
92
2.50
3.65
3.5
4.0
35.8
35.2
mg/l
0.02
17
74
22
92
2.50
3.65
2.6
1.8
—
—
—
0
0
22
92
2.50
3.65
3.5
4.0
37.5
144.7
mg/l
0.87
16
73
30
145
2.19
3.62
1.3
1.2
—
—
—
0
0
139
1064
1.57
3.60
2.4
2.0
100.9
93.7
pmol/l
0.92
68
566
273
2478
2.09
3.52
13.0
11.5
25.0
25.0
u/l
0.01
262
2370
18
70
2.67
3.45
1.7
1.5
219.9
279.0
ug/g
0.63
11
40
257
2293
1.83
3.41
5.9
5.0
6.4
6.1
mmol/l
2.90
229
2049
77
517
1.66
3.41
5.7
4.6
1.0
1.0
kg/l
0.79
11
70
278
2549
2.19
3.35
31.5
24.6
240.7
240.8
e9/l
0.01
272
2475
278
2549
2.19
3.35
31.3
24.5
91.4
91.6
fl
0.30
273
2501
278
2550
2.18
3.32
31.6
24.6
7.1
6.9
e9/l
1.00
273
2466
278
2550
2.18
3.32
31.7
24.7
132.6
134.2
g/l
0.84
273
2500
278
2550
2.18
3.32
31.5
24.6
4.4
4.4
e12/l
0.96
273
2466
278
2550
2.18
3.32
31.3
24.5
30.4
30.5
pg
0.02
273
2502
259
2321
1.83
3.32
22.2
16.9
30.3
26.2
mg/l
0.96
222
1888
256
2287
1.80
3.30
5.5
4.8
4.3
4.5
mmol/l
1.51
229
2072
13
43
3.11
3.29
3.6
2.9
—
—
—
0
0
91
644
1.59
3.24
6.0
4.3
0.0
0.0
estimate
0.00
26
211
254
2269
1.76
3.21
5.6
4.7
1.4
1.4
mmol/l
0.14
226
2037
13
44
3.04
3.17
3.6
2.8
4.0
4.1
mmol/l
0.11
13
44
13
44
3.04
3.17
3.6
2.8
104.2
105.7
mmol/l
0.43
13
44
107
793
1.54
3.10
5.8
4.3
—
—
—
0
0
17
68
2.59
3.10
6.7
11.7
—
—
—
0
0
16
62
2.67
3.10
3.8
4.4
—
—
—
0
0
28
142
2.07
3.01
6.4
4.2
—
—
—
0
0
58
374
1.68
2.97
24.3
25.8
1.4
1.3
inr
—
5
49
247
2204
1.67
2.96
4.9
4.2
1.4
1.3
mmol/l
1.35
217
1967
19
84
2.35
2.83
7.1
5.3
—
—
—
0
0
38
220
1.83
2.81
3.9
3.5
—
—
—
0
0
91
668
1.52
2.70
1.7
1.6
25.2
20.2
nmol/l
1.61
73
553
10
32
3.20
2.67
1.8
1.3
—
—
—
0
0
34
194
1.85
2.64
3.5
4.0
—
—
—
0
0
38
227
1.77
2.55
3.5
3.1
4.5
4.3
kpa
0.32
38
215
164
1365
1.44
2.53
6.7
6.8
10.1
11.6
umol/l
1.98
156
1293
19
90
2.19
2.44
4.1
3.0
3.7
4.0
mmol/l
1.88
19
80
145
1190
1.42
2.36
7.0
6.1
1.2
1.2
mmol/l
0.01
126
1057
44
281
1.66
2.34
4.0
3.8
—
—
—
0
0
42
268
1.66
2.24
4.0
3.8
2.1
2.0
mmol/l
0.05
35
206
23
122
1.96
2.23
1.2
1.2
—
—
—
0
0
22
115
1.99
2.22
1.7
1.3
—
—
—
0
0
37
229
1.70
2.21
2.9
2.0
368.1
378.8
nmol/l
0.13
32
209
137
1124
1.40
2.19
5.1
6.1
26.2
26.3
%
0.04
122
1038
42
271
1.64
2.15
4.0
3.8
5.7
5.8
kpa
0.16
42
260
73
537
1.47
2.10
4.6
3.0
547.8
566.6
mosm/kgh2o
0.26
65
445
229
2065
1.46
2.05
20.4
18.0
38.0
39.1
%
0.50
130
1331
134
1105
1.38
2.04
4.9
5.8
58.7
58.3
%
0.12
120
1033
56
394
1.52
2.00
2.4
2.0
—
—
—
0
0
133
1099
1.38
1.98
5.2
6.2
9.0
8.8
%
0.17
119
1026
49
336
1.55
1.96
1.4
1.3
21.7
8.9
u/ml
0.26
17
132
135
1121
1.37
1.94
5.4
5.4
2.9
2.9
ug/l
0.01
118
985
6
16
3.80
1.94
1.8
1.3
—
—
—
0
0
13
58
2.30
1.93
4.1
4.1
—
—
—
0
0
38
246
1.62
1.93
1.9
3.0
64.8
69.4
e9/l
0.63
31
192
132
1094
1.37
1.92
4.8
5.8
2.7
2.8
%
0.12
118
1018
129
1069
1.36
1.86
4.8
5.8
0.6
0.6
%
0.29
115
999
136
1137
1.36
1.85
11.4
9.5
1.3
1.3
inr
0.07
45
319
39
258
1.59
1.82
5.1
4.3
—
—
—
0
0
20
110
1.88
1.77
5.9
4.0
—
—
—
0
0
9
36
2.55
1.75
2.3
2.4
—
—
—
0
0
22
126
1.80
1.73
5.7
3.7
—
—
—
0
0
14
68
2.11
1.73
1.1
1.6
—
—
—
0
0
22
127
1.79
1.69
2.7
2.4
—
—
—
0
0
138
1171
1.33
1.65
4.8
5.5
0.0
0.0
e9/l
0.43
119
1015
98
795
1.35
1.58
4.8
5.8
—
—
—
0
0
47
337
1.47
1.54
1.3
1.3
—
—
—
0
0
70
541
1.38
1.53
4.8
4.1
—
—
—
0
0
134
1142
1.31
1.53
4.5
4.1
—
—
—
0
0
7
27
2.63
1.52
1.6
1.1
—
—
—
0
0
158
1379
1.31
1.51
8.2
9.6
4.4
4.3
e9/l
0.34
140
1211
100
819
1.33
1.51
5.1
3.4
621.3
145.3
e6/l
0.36
83
627
139
1193
1.31
1.50
5.0
5.7
1.8
1.9
e9/l
0.57
120
1059
140
1206
1.30
1.46
5.0
5.8
0.2
0.2
e9/l
0.40
122
1062
136
1168
1.30
1.44
4.9
5.5
0.6
0.6
e9/l
0.04
119
1005
42
299
1.47
1.43
2.9
4.7
21.8
46.4
ug/l
0.34
34
248
49
364
1.41
1.35
1.4
1.2
26.9
38.5
iu/ml
0.57
17
119
80
645
1.33
1.33
7.3
3.8
—
—
—
0
0
21
130
1.66
1.30
2.5
3.0
—
—
—
0
0
109
920
1.29
1.29
5.8
4.0
93.9
94.8
e6/l
0.00
87
672
5
18
2.81
1.29
1.8
1.3
—
—
—
0
0
82
668
1.31
1.26
2.9
2.1
2.8
3.1
mg/l
0.65
70
570
25
165
1.56
1.22
4.1
3.4
4.3
4.0
e9/l
0.22
15
125
5
19
2.66
1.22
1.0
1.1
—
—
—
0
0
5
19
2.66
1.22
2.4
1.3
—
—
—
0
0
5
19
2.66
1.22
1.0
1.1
—
—
—
0
0
70
561
1.32
1.21
3.9
2.6
5.1
4.5
e6/l
0.08
63
484
90
748
1.29
1.19
5.0
3.2
0.3
0.5
e6/l
0.84
74
557
27
183
1.52
1.18
6.8
5.9
25.3
24.5
mmol/l
0.66
27
174
38
279
1.41
1.13
1.6
1.3
—
—
—
0
0
50
385
1.36
1.13
2.4
2.4
19.5
22.0
%
0.97
39
330
52
403
1.35
1.12
2.4
2.3
2.4
2.3
g/l
0.64
44
367
93
782
1.27
1.12
4.8
4.3
7.4
7.4
ph
0.29
17
144
7
31
2.29
1.11
1.4
1.5
—
—
—
0
0
7
31
2.29
1.11
1.4
1.5
—
—
—
0
0
7
31
2.29
1.11
1.4
1.5
—
—
—
0
0
7
31
2.29
1.11
1.4
1.5
—
—
—
0
0
5
21
2.40
1.09
1.4
1.2
—
—
—
0
0
103
880
1.26
1.09
2.5
3.6
2.3
2.3
mmol/l
0.25
83
767
18
114
1.62
1.05
1.4
3.4
4.2
4.4
pmol/l
0.39
18
102
39
292
1.39
1.05
2.8
1.7
—
—
—
0
0
28
197
1.46
1.04
2.4
4.2
0.6
1.1
%
—
5
76
25
173
1.49
1.01
6.0
3.0
—
—
—
0
0
7
35
2.02
1.00
2.1
3.9
—
—
—
0
0
7
35
2.02
1.00
1.1
1.1
—
—
—
0
0
111
965
1.24
0.99
3.4
2.6
121.4
147.0
ug/l
0.76
97
875
5
23
2.19
0.98
1.0
1.5
—
—
—
0
0
43
332
1.34
0.96
4.7
6.7
1.5
1.5
mmol/l
0.06
37
267
10
55
1.85
0.93
3.6
2.1
—
—
—
0
0
13
78
1.70
0.93
2.8
2.6
345.6
82.0
ug/min
—
6
40
95
819
1.23
0.91
2.5
2.4
—
—
—
0
0
28
203
1.42
0.91
2.9
2.2
304.1
151.1
ug/g
0.47
18
168
12
71
1.72
0.90
1.7
1.5
—
—
—
0
0
13
79
1.67
0.89
2.7
2.5
26.1
24.8
mmol/l
0.70
13
64
15
95
1.61
0.89
2.5
3.6
0.3
0.2
g/l
—
8
35
201
1874
1.22
0.86
26.1
22.3
332.7
331.8
g/l
0.85
201
1860
63
522
1.26
0.85
1.5
1.8
1.6
1.4
mg/l
0.10
47
417
6
31
1.95
0.85
1.0
1.3
—
—
—
0
0
6
31
1.95
0.85
1.0
1.3
—
—
—
0
0
6
32
1.89
0.82
1.0
1.3
—
—
—
0
0
6
32
1.89
0.82
1.0
1.3
—
—
—
0
0
76
649
1.23
0.79
1.9
1.6
1.4
1.3
mmol/l
0.56
54
528
6
33
1.83
0.79
1.7
2.1
33.5
32.9
pg
—
6
33
61
512
1.24
0.75
5.5
3.9
138.2
340.2
ng/l
1.13
47
425
9
55
1.66
0.74
2.9
2.5
—
—
—
0
0
6
110
0.54
0.73
1.2
1.5
—
—
—
0
0
10
60
1.69
0.73
1.8
1.2
—
—
—
0
0
5
26
1.94
0.71
1.0
1.5
—
—
—
0
0
11
69
1.62
0.69
2.6
2.4
7.6
7.9
kpa
0.31
11
61
5
28
1.80
0.66
1.0
1.4
0.5
0.6
nmol/l
—
5
23
5
28
1.80
0.66
1.2
2.6
—
—
—
0
0
81
709
1.19
0.66
5.1
3.2
—
—
—
0
0
40
325
1.27
0.65
1.8
2.8
1.7
1.8
%
0.38
31
293
5
29
1.74
0.64
1.0
1.3
—
—
—
0
0
8
49
1.65
0.62
1.1
1.4
—
—
—
0
0
9
139
0.64
0.62
1.4
1.4
—
—
—
0
0
5
30
1.68
0.61
1.0
1.0
—
—
—
0
0
11
72
1.55
0.60
1.2
1.1
—
—
—
0
0
53
451
1.21
0.58
2.6
2.3
10.9
12.5
umol/l
1.08
46
409
34
276
1.26
0.57
5.5
7.3
116.6
120.8
g/l
0.67
34
270
80
710
1.17
0.56
3.8
3.3
—
—
—
0
0
6
37
1.63
0.56
1.0
1.7
—
—
—
0
0
56
482
1.20
0.55
5.1
4.8
—
—
—
0
0
6
38
1.59
0.54
1.3
1.2
11.5
8.6
u/l
—
6
29
6
39
1.55
0.53
2.0
1.8
—
—
—
0
0
7
45
1.57
0.49
4.0
3.0
—
—
—
0
0
23
185
1.26
0.43
1.5
1.3
—
—
—
0
0
25
204
1.25
0.42
7.4
3.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
1.8
—
0
16
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.5
—
0.2
—
0
9
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
14
106
1.34
0.40
1.4
2.1
156.9
335.9
ug/l
1.42
14
99
0
19
0.00
0.39
0.0
3.5
—
—
—
0
0
5
36
1.40
0.38
1.2
2.0
80.9
89.3
%
—
5
36
35
300
1.19
0.38
1.6
1.4
—
—
—
0
0
28
235
1.21
0.37
5.5
7.8
—
—
—
0
0
9
69
1.31
0.37
1.0
1.1
—
—
—
0
0
9
69
1.31
0.37
1.8
2.1
13.7
12.6
mg/l
—
9
63
26
226
1.16
0.26
1.4
1.6
—
—
—
0
0
6
81
0.74
0.24
5.0
6.5
1.1
1.4
mmol/l
—
6
75
30
268
1.13
0.21
1.1
1.7
—
—
—
0
0
5
42
1.19
0.21
1.2
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
0.2
—
0
5
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
6
50
1.20
0.20
1.3
1.5
—
—
—
0
0
8
72
1.11
0.16
1.4
1.3
—
3.3
—
0
8
177
1730
1.06
0.15
5.0
4.4
—
—
—
0
0
12
102
1.18
0.15
1.2
1.3
—
—
—
0
0
109
1052
1.06
0.15
12.4
10.2
0.0
0.0
e9/l
0.44
96
864
13
150
0.86
0.15
8.0
9.4
—
—
—
0
0
61
581
1.06
0.13
1.4
1.3
—
—
—
0
0
15
134
1.13
0.11
1.2
1.2
—
43.9
—
0
10
25
231
1.09
0.11
1.6
1.5
—
—
—
0
0
30
320
0.93
0.10
1.2
1.3
—
—
—
0
0
24
257
0.93
0.09
3.6
2.5
4.3
8.3
ug/l
1.58
18
224
6
56
1.07
0.08
1.0
1.1
—
—
—
0
0
17
185
0.91
0.08
1.8
1.5
—
—
—
0
0
5
62
0.80
0.08
1.2
3.2
—
—
—
0
0
10
88
1.14
0.08
1.1
1.7
—
—
—
0
0
6
70
0.85
0.07
1.7
1.5
166769.2
19901.4
e6/l
—
6
54
8
78
1.03
0.07
4.3
3.5
—
—
—
0
0
7
82
0.85
0.07
1.4
2.4
20.7
22.0
s
—
7
75
54
522
1.04
0.07
2.0
3.1
2.4
2.5
mmol/l
0.19
42
464
96
976
0.98
0.04
2.5
2.2
—
—
—
0
0
27
281
0.96
0.04
1.5
1.3
194.3
511.5
titre
—
7
66
24
230
1.05
0.03
1.3
1.5
—
—
—
0
0
61
619
0.98
0.02
8.8
6.8
—
—
—
0
0
63
637
0.99
0.01
2.8
3.2
0.9
0.8
ug/l
0.13
43
447
11
111
0.99
0.00
1.2
1.3
—
—
—
0
0
22
215
1.03
0.00
1.2
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.7
—
—
—
0
0
5
51
0.98
0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
17.2
—
1685.0
—
0
5
0
5
0.00
0.00
0.0
1.6
—
38.2
—
0
5
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
5
51
0.98
0.00
1.6
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
57.0
—
0
5
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
5
57
0.88
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
3.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
12.6
—
882.6
—
0
5
0
9
0.00
0.00
0.0
4.8
—
54.3
—
0
9
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
5
53
0.94
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
14.9
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_VITRCRYSTAL and mortality.

Females

Parameter HR [95% CI] p-value
H7_VITRCRYSTAL 0.983 [0.8, 1.21] 0.868
Birth year 0.996 [0.99, 1.0] 0.342

During the follow-up period (1.1.1998 — 31.12.2019), 133 out of 603 females with H7_VITRCRYSTAL died.

Males

Parameter HR [95% CI] p-value
H7_VITRCRYSTAL 0.981 [0.8, 1.2] 0.852
Birth year 0.989 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 251 out of 834 males with H7_VITRCRYSTAL died.

Mortality risk

Mortality risk for people of age

years, who have H7_VITRCRYSTAL.

N-year risk Females Males
1 0.063% 0.173%
5 0.566% 1.147%
10 1.412% 2.925%
15 2.787% 5.421%
20 4.935% 9.54%

Relationships between endpoints

Index endpoint: H7_VITRCRYSTAL – Crystalline deposits in vitreous body

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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