No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
167 |
4. Check minimum number of eventsNone |
167 |
5. Include endpointsNone |
167 |
6. Filter based on genotype QC (FinnGen only) |
167 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H73
- Name in latin
- Myringitis chronica
Similar endpoints
↥List of similar endpoints to
Chronic myringitis
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1468 | 726 | 734 |
| Only index persons | 1375 | 692 | 683 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 43.87 | 44.67 | 43.07 |
| Only index persons | 44.96 | 45.66 | 44.24 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 167 | 89 | 78 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 55.85 | 55.17 | 56.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 145
- Matched controls
- 1450
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H73.1
ICD-10 Finland
Chronic myringitis
+∞
203.5
143
*
UDC00
NOMESCO Finland
Ear microscopy
62.5
79.1
93
40
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
1118.1
71.5
64
*
DCD00
NOMESCO Finland
Myringoplasty
+∞
44.0
40
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
25.3
32.4
46
26
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
299.5
25.5
25
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
299.5
25.5
25
*
H66.9
ICD-10 Finland
Otitis media, unspecified
19.3
25.3
39
27
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
+∞
21.4
20
*
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
47.4
20.2
24
6
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
216.9
19.0
19
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
+∞
18.1
17
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
11.5
17.4
33
36
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
40.5
17.2
21
6
DC1AD
NOMESCO Finland
Temporalbone CT
191.1
16.9
17
*
H04
ICPC
Ear discharge
20.2
16.3
24
14
S02CA02
ATC
flumetasone and antiinfectives; otic
11.9
16.2
30
31
H60.8
ICD-10 Finland
Other otitis externa
30.4
16.1
21
8
Z01.1
ICD-10 Finland
Examination of ears and hearing
6.0
14.6
44
98
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
+∞
13.8
13
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
153.8
13.7
14
*
H01
ICPC
Ear pain/earache
6.3
12.5
35
70
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.6
12.0
73
315
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
70.8
11.8
13
*
H65.2
ICD-10 Finland
Chronic serous otitis media
+∞
11.6
11
*
H60.3
ICD-10 Finland
Other infective otitis externa
22.2
11.4
16
8
TDA90
NOMESCO Finland
Removal wax from ear
47.3
11.1
13
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.6
11.1
42
118
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.6
10.6
61
246
DFF00
NOMESCO Finland
Pure tone audiometry
5.7
10.5
31
66
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
3.1
9.8
92
519
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
9.5
9
*
DCD10
NOMESCO Finland
Tympanoplasty
+∞
9.5
9
*
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
9.5
9
*
WX720
NOMESCO Finland
Own respiration
8.0
9.4
21
30
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
39.3
9.2
11
*
SPAT1044
SPAT
Tympanometry
20.2
9.1
13
7
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
29.5
8.6
11
*
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
+∞
8.4
8
*
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
8.4
8
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
8.4
8
*
H73.0
ICD-10 Finland
Acute myringitis
47.6
7.8
9
*
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
84.2
7.5
8
*
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
+∞
7.3
7
*
H65.0
ICD-10 Finland
Acute serous otitis media
31.7
7.2
9
*
H71
ICPC
Acute otitis media/myringitis
31.7
7.2
9
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
7.7
7.2
16
23
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
10.9
7.2
13
13
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
11.8
6.9
12
11
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
42.1
6.8
8
*
4122
FHL
Tympanostomy (tympanic tube)
72.9
6.5
7
*
WX704
NOMESCO Finland
Intubation
4.5
6.4
22
55
H72.8
ICD-10 Finland
Other perforations of tympanic membrane
+∞
6.3
6
*
DCA40
NOMESCO Finland
Fat patching or other similar technique without opening of tympanic membrane
+∞
6.3
6
*
H60
ICD-10 Finland
Otitis externa
6.3
6.0
15
26
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
86
4.71
12.93
2.5
2.5
54.9
166.1
ng/l
2.53
29
78
47
239
2.35
5.35
2.4
3.4
111.5
102.4
ng/l
0.04
29
178
55
305
2.20
5.07
3.7
3.6
1.0
1.0
kg/l
0.82
11
41
133
1046
2.33
4.74
4.2
3.9
14.8
14.7
pmol/l
0.15
121
934
105
781
1.93
4.00
3.8
5.9
7.0
6.8
mmol/l
0.27
90
728
131
1059
2.10
3.83
6.0
7.8
72.8
79.3
u/l
1.54
122
991
88
647
1.76
3.21
5.4
7.8
1.2
1.2
mmol/l
0.86
74
542
145
1269
2.08
2.68
5.4
4.6
1.9
1.9
mu/l
0.09
136
1152
24
123
2.11
2.61
1.8
2.1
413.5
399.8
nmol/l
0.13
24
112
45
291
1.75
2.47
1.7
1.6
143243632.8
469.4
pmol/l
0.49
37
250
112
1292
0.60
2.42
11.0
13.1
85.0
82.8
ml/min/173m2
0.56
86
1057
57
399
1.65
2.33
1.6
2.1
109.6
158.2
u/l
1.94
51
380
75
563
1.60
2.31
3.6
5.3
36.6
35.7
g/l
0.78
67
531
153
1389
2.21
2.19
11.0
13.9
21.0
22.7
mg/l
0.25
126
1074
70
523
1.58
2.17
4.0
3.6
—
—
—
0
0
66
496
1.55
1.95
2.2
1.9
95.6
94.4
pmol/l
0.08
37
254
25
145
1.85
1.95
1.6
1.7
—
—
—
0
0
24
139
1.85
1.88
1.8
1.7
—
—
—
0
0
5
12
4.26
1.83
1.0
1.3
—
—
—
0
0
35
235
1.62
1.65
1.5
1.7
1014.5
1214.9
nmol/l
0.95
30
185
69
540
1.47
1.63
2.5
2.4
82.1
76.5
nmol/l
0.84
64
473
15
78
2.01
1.60
3.1
3.8
4.6
4.5
pmol/l
0.18
15
68
20
323
0.57
1.58
2.0
2.4
—
—
—
0
0
142
1292
1.66
1.54
14.6
14.8
39.9
40.1
%
0.07
71
966
86
709
1.44
1.52
5.5
6.9
9.9
11.6
umol/l
1.98
80
679
56
426
1.47
1.51
2.2
2.9
56.0
55.9
u/l
0.01
50
397
145
1340
1.62
1.30
5.3
4.4
6.1
5.9
mmol/l
0.76
134
1237
149
1389
1.67
1.25
5.5
4.9
2.7
2.8
mmol/l
0.56
135
1282
33
234
1.51
1.24
1.3
1.3
1.1
6.2
u/ml
—
10
85
147
1367
1.63
1.23
4.9
4.4
4.5
4.6
mmol/l
0.61
137
1271
16
94
1.78
1.22
1.3
1.1
53.8
198.0
iu/ml
2.17
11
35
5
19
2.68
1.22
4.2
1.1
—
—
—
0
0
80
670
1.37
1.21
3.9
3.5
0.0
0.0
estimate
—
8
134
0
34
0.00
1.17
0.0
1.3
—
—
—
0
0
29
203
1.52
1.15
1.9
1.9
—
—
—
0
0
76
636
1.36
1.14
4.4
4.3
—
—
—
0
0
14
227
0.58
1.13
1.8
3.2
2.5
2.5
mmol/l
0.48
14
194
138
1273
1.48
1.12
6.5
5.6
40.7
39.9
mmol/mol
0.43
128
1191
57
460
1.36
1.06
3.9
3.6
27.9
29.8
u/l
0.35
49
437
62
508
1.35
1.05
2.7
3.7
17.1
33.0
ng/l
2.35
37
356
22
150
1.54
0.99
3.1
13.0
1.9
1.1
mmol/l
0.32
13
122
9
50
1.84
0.98
1.3
1.8
—
—
—
0
0
29
385
0.70
0.94
2.2
2.9
0.2
0.6
e6/l
1.24
23
279
38
293
1.38
0.93
1.5
1.5
21.2
21.9
nmol/l
0.12
32
244
6
28
2.18
0.92
1.3
1.4
—
—
—
0
0
28
207
1.42
0.87
1.6
1.3
—
—
—
0
0
144
1357
1.44
0.86
4.6
4.4
1.4
1.5
mmol/l
2.14
131
1252
6
31
1.97
0.85
1.3
1.3
—
—
—
0
0
8
47
1.74
0.82
1.8
1.7
—
—
—
0
0
12
183
0.63
0.77
1.5
1.9
1.7
1.5
%
0.93
12
159
55
461
1.29
0.77
5.9
4.8
2.4
1.9
ug/l
0.40
48
411
32
248
1.36
0.76
1.3
1.2
17.2
27.7
iu/ml
—
10
78
42
340
1.31
0.76
1.2
1.3
0.9
1.4
u/ml
—
9
97
5
24
2.12
0.75
1.6
1.5
—
—
—
0
0
20
143
1.45
0.74
2.2
4.4
209.2
239.1
u/l
1.54
20
138
5
25
2.03
0.73
1.4
1.4
—
—
—
0
0
45
370
1.30
0.72
4.7
4.4
18.6
21.3
%
0.80
15
168
77
679
1.25
0.70
5.4
4.8
0.0
0.0
estimate
—
9
134
78
689
1.25
0.70
3.9
3.5
0.0
0.0
estimate
—
8
122
8
129
0.60
0.67
1.9
1.7
—
—
—
0
0
104
959
1.22
0.59
2.7
3.4
38.7
49.7
u/l
1.55
98
900
6
39
1.56
0.53
1.5
1.5
—
—
—
0
0
37
309
1.25
0.53
2.1
2.2
2.7
3.0
mg/l
0.56
31
263
52
452
1.22
0.52
2.5
3.4
2.3
2.4
mmol/l
0.32
46
393
31
256
1.26
0.49
1.5
1.5
—
—
—
0
0
86
789
1.19
0.48
6.5
9.3
4.2
4.1
e9/l
0.07
79
682
7
49
1.45
0.46
1.3
1.5
24.2
20.7
iu/l
—
7
39
8
56
1.45
0.43
1.0
2.3
26.6
39.5
u/l
—
8
49
5
32
1.58
0.42
1.4
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
137
1317
1.22
0.41
3.9
4.0
1.4
1.3
mmol/l
1.11
123
1208
0
16
0.00
0.41
0.0
3.8
—
20.6
—
0
6
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.7
—
—
—
0
0
0
17
0.00
0.41
0.0
1.7
—
—
—
0
0
0
17
0.00
0.41
0.0
1.7
—
—
—
0
0
6
41
1.48
0.36
1.5
1.5
—
—
—
0
0
12
155
0.76
0.35
5.4
7.7
—
—
—
0
0
33
287
1.19
0.33
1.3
1.7
1.0
1.5
mg/l
0.70
21
224
12
97
1.26
0.23
1.2
1.6
—
—
—
0
0
5
38
1.33
0.23
3.0
1.9
2.9
5.9
iu/l
—
5
14
7
91
0.76
0.23
4.0
2.9
5.0
5.2
kpa
—
7
85
5
39
1.29
0.23
1.8
1.4
—
—
—
0
0
12
145
0.81
0.22
3.0
3.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
9.3
—
0
6
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
6
48
1.26
0.20
1.3
1.7
210.0
345.2
mu/l
—
6
43
24
269
0.87
0.20
3.2
3.0
1.0
0.7
ug/l
0.45
12
176
40
370
1.11
0.18
4.2
3.6
0.0
0.0
estimate
—
9
131
7
62
1.13
0.17
1.6
1.7
—
—
—
0
0
7
86
0.81
0.15
6.1
8.6
25.1
25.2
mmol/l
—
7
86
7
85
0.82
0.15
1.4
1.3
—
—
—
0
0
45
476
0.93
0.13
2.4
3.1
—
—
—
0
0
19
176
1.09
0.08
1.5
2.2
—
—
—
0
0
7
68
1.03
0.08
1.6
1.4
—
—
—
0
0
94
921
1.05
0.08
3.1
3.1
—
—
—
0
0
8
74
1.09
0.07
1.3
1.3
—
—
—
0
0
9
87
1.04
0.07
1.6
1.8
—
—
—
0
0
20
187
1.08
0.06
1.6
2.4
—
—
—
0
0
11
100
1.11
0.05
1.5
2.1
—
—
—
0
0
17
159
1.08
0.05
5.5
4.6
29.0
31.8
%
—
8
100
23
232
0.99
0.00
2.0
3.4
0.8
0.8
mmol/l
0.50
23
220
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
8.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
6.6
—
206.8
—
0
5
0
8
0.00
0.00
0.0
1.4
—
1061.1
—
0
8
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
8
88
0.90
0.00
1.1
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
11.8
—
0
9
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
4.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_MYRINGCHRON and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MYRINGCHRON | 0.971 [0.69, 1.37] | 0.867 |
| Birth year | 0.995 [0.99, 1.0] | 0.274 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 610 females with H8_MYRINGCHRON died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MYRINGCHRON | 0.866 [0.64, 1.18] | 0.359 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 607 males with H8_MYRINGCHRON died.
Mortality risk
Mortality risk for people of age
years, who have H8_MYRINGCHRON.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.183% |
| 5 | 0.575% | 0.998% |
| 10 | 1.505% | 2.504% |
| 15 | 2.861% | 4.861% |
| 20 | 4.939% | 8.169% |
Relationships between endpoints
↥Index endpoint: H8_MYRINGCHRON – Chronic myringitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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