≡ Risteys
R13

Documentation Changelog GitHub Contact & Feedback

Cerebral amyloid angiopathy

DOID EFO Endpoint Browser PheWeb

I9_CEREBAMY

cerebral amyloid angiopathy: Hereditary cerebral hemorrhage with amyloidosis (HCHWA) describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

160

4. Check minimum number of events

None

160

5. Include endpoints

None

160

6. Filter based on genotype QC (FinnGen only)

153

Control definitions (FinnGen only)

Control exclude
I9_CEREBVASC

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 791 364 421
Only index persons 742 344 398
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.02
Median age at first event (years)
Whole population 74.51 75.07 73.97
Only index persons 74.47 75.07 73.94

-FinnGen-

Key figures

All Female Male
Number of individuals 153 61 92
Unadjusted period prevalence (%) 0.03 0.02 0.04
Median age at first event (years) 74.37 73.30 75.08

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
160
Matched controls
1600
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I68.0*E85.9
ICD-10 Finland
Cerebral amyloid angiopathy
+∞
171.0
132
*
I68.0
ICD-10 Finland
Cerebral amyloid angiopathy
+∞
59.1
53
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
15.8
55.7
57
54
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
213.2
46.6
46
*
AA1AD
NOMESCO Finland
CT of head and brain
9.5
44.8
110
300
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
100.1
41.4
44
6
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
+∞
33.5
31
*
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
15.1
32.5
31
25
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
+∞
32.4
30
*
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
+∞
31.3
29
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
6.3
29.7
76
201
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
+∞
29.0
27
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
8.3
24.1
36
54
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
7.4
23.1
39
67
E85.9
ICD-10 Finland
Amyloidosis, unspecified
253.2
22.2
22
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
5.9
21.0
46
102
P20
ICPC
Memory disturbance
4.4
17.7
61
195
K90
ICPC
Stroke/cerebrovascular accident
40.2
14.8
18
5
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
11.7
14.1
26
26
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
+∞
13.7
13
*
R4120
NOMESCO Finland
Occupational therapy
6.7
13.5
23
39
N03AX14
ATC
levetiracetam; systemic
21.3
13.3
19
10
R51.80
ICD-10 Finland
Headache
4.2
12.2
39
115
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
128.9
11.6
12
*
A28
ICPC
Limited function/disability NOS
3.4
11.3
52
196
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
19.6
11.0
16
9
N19
ICPC
Speech disorder
64.4
10.8
12
*
E85.4
ICD-10 Finland
Organ-limited amyloidosis
+∞
10.5
10
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
4.8
10.1
25
60
R47.0
ICD-10 Finland
Dysphasia and aphasia
58.6
9.8
11
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
16.4
9.7
15
10
XA800
NOMESCO Finland
Neuropsychological investigation
16.4
9.7
15
10
N03AF02
ATC
oxcarbazepine; oral
13.5
9.6
16
13
G40.9
ICD-10 Finland
Epilepsy, unspecified
10.5
9.6
18
19
R41.0
ICD-10 Finland
Disorientation, unspecified
9.5
9.1
18
21
N06DX01
ATC
memantine; oral
3.8
9.0
31
95
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
12.6
8.8
15
13
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
7.5
8.7
20
30
K91
ICPC
Cerebrovascular disease
29.3
8.6
11
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
+∞
8.4
8
*
SPAT1216
SPAT
Assessment of functional ability
3.0
8.2
46
191
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
19.5
7.7
11
6
R55
ICD-10 Finland
Syncope and collapse
3.4
7.7
32
111
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
26.5
7.7
10
*
L28
ICPC
Limited function/disability (L)
2.9
7.7
46
198
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
7.3
7
*
FFW96
NOMESCO Finland
Other operation on atria
+∞
7.3
7
*
FFM32
NOMESCO Finland
Occlusion or excision of atrial appendage transvenously with a closing device
+∞
7.3
7
*
I67.8
ICD-10 Finland
Other specified cerebrovascular diseases
+∞
7.3
7
*
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
21.2
7.2
10
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
7.0
104
682
N05AX08
ATC
risperidone; systemic
3.6
6.4
23
72
N01
ICPC
Headache
3.6
6.4
22
67
PA6AD
NOMESCO Finland
CT of neck arteries
9.9
6.4
12
13
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
11.7
6.4
11
10
R4130
NOMESCO Finland
Speech therapy
11.7
6.4
11
10
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
18.9
6.3
9
5
I61.6
ICD-10 Finland
Intracerebral haemorrhage, multiple localized
+∞
6.3
6
*
AAB30
NOMESCO Finland
Evacuation of spontaneous intracranial haematoma
+∞
6.3
6
*
X59
ICD-10 Finland
Exposure to unspecified factor
2.8
6.2
37
157
N05AH04
ATC
quetiapine; oral
2.9
6.2
32
126
F01.9
ICD-10 Finland
Vascular dementia, unspecified
13.2
6.2
10
8
R42
ICD-10 Finland
Dizziness and giddiness
2.5
6.1
50
248

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
21
17
14.02
12.54
1.3
1.3
—
—
—
0
0
122
759
3.56
11.18
8.5
7.1
1.22
1.21
mmol/l
0.75
99
630
114
696
3.22
10.48
6.1
6.3
1.21
1.21
mmol/l
0.07
101
616
137
941
4.17
10.25
7.2
4.5
—
—
—
0
0
105
632
2.92
9.53
2.5
2.1
85.31
95.34
pmol/l
1.28
64
334
81
445
2.66
8.49
4.1
3.2
—
—
—
0
0
64
315
2.72
8.33
2.1
1.7
1000.13
1229.91
nmol/l
1.61
51
234
74
392
2.65
8.31
1.8
1.6
17.30
21.22
nmol/l
1.88
61
320
104
651
2.71
8.28
6.0
4.6
34.70
35.19
g/l
0.44
99
601
139
1023
3.73
8.06
5.5
4.2
14.99
13.58
mm/h
0.40
130
919
155
1331
6.26
6.58
24.8
16.2
24.47
25.33
mg/l
0.13
137
1067
111
764
2.48
6.55
12.1
15.0
1.25
1.31
inr
0.29
37
219
152
1287
4.62
6.31
6.3
6.6
40.44
40.77
mmol/mol
0.16
138
1173
25
85
3.30
6.17
9.2
9.6
—
—
—
0
0
151
1289
4.05
5.59
5.3
5.0
1.41
1.45
mmol/l
0.58
141
1153
152
1305
4.29
5.57
5.3
5.0
4.27
4.44
mmol/l
1.34
141
1177
140
1114
3.05
5.52
8.5
7.9
75.60
80.01
u/l
0.99
130
1036
9
8
11.82
5.36
1.6
1.3
—
—
—
0
0
34
152
2.57
5.12
3.3
4.0
—
—
—
0
0
71
437
2.12
5.07
4.1
4.4
—
—
—
0
0
153
1341
4.22
4.87
5.9
5.6
2.45
2.58
mmol/l
1.01
142
1201
54
305
2.16
4.75
6.9
3.6
325.77
224.67
ng/l
0.14
48
262
8
8
10.44
4.57
1.1
1.1
—
—
—
0
0
147
1239
3.29
4.49
5.0
4.7
1.94
2.02
mu/l
0.35
135
1085
88
608
1.99
4.40
8.3
6.3
9.05
8.97
%
0.08
80
565
87
603
1.97
4.27
7.8
5.9
2.69
2.92
%
0.38
79
558
85
585
1.97
4.25
7.4
5.9
0.64
0.64
%
0.00
77
542
153
1362
3.82
4.20
24.0
15.9
—
—
—
0
0
93
662
1.97
4.19
7.4
5.7
1.54
1.90
e9/l
1.37
85
595
88
616
1.95
4.16
8.1
6.2
22.48
25.99
%
2.31
81
571
94
673
1.96
4.15
7.2
5.8
0.18
0.20
e9/l
0.51
84
594
146
1246
2.96
3.95
4.5
4.4
1.18
1.24
mmol/l
0.75
134
1107
91
653
1.91
3.91
7.1
5.6
0.04
0.04
e9/l
0.30
82
568
86
606
1.91
3.90
7.8
5.8
62.28
58.25
%
2.32
79
561
70
466
1.89
3.74
4.3
4.3
7.41
7.40
ph
0.33
19
87
70
470
1.87
3.61
2.3
2.4
58.92
66.58
u/l
0.34
64
438
54
333
1.94
3.61
4.7
4.1
89.81
86.61
%
0.51
54
327
75
515
1.86
3.61
3.9
3.6
2.33
2.35
mmol/l
0.65
63
444
85
610
1.84
3.52
7.8
6.7
—
—
—
0
0
52
319
1.93
3.52
3.3
3.0
553.87
547.99
mosm/kgh2o
0.07
45
274
89
649
1.84
3.49
7.2
5.6
0.62
0.60
e9/l
0.26
82
560
122
984
2.01
3.49
3.8
3.9
15.65
15.03
pmol/l
1.29
110
861
59
381
1.87
3.40
1.9
1.9
2.85
3.12
mg/l
0.39
50
325
25
117
2.35
3.38
3.5
2.1
—
—
—
0
0
6
8
7.73
3.08
1.3
1.3
—
—
—
0
0
71
498
1.77
3.06
4.6
4.5
—
—
—
0
0
101
786
1.77
3.01
9.4
9.4
4.67
4.20
e9/l
0.50
88
694
84
626
1.72
2.87
4.8
4.1
39.73
42.62
ng/l
0.07
72
499
9
23
4.08
2.82
1.6
1.3
—
—
—
0
0
57
384
1.75
2.77
1.9
1.7
1.16
1.25
mmol/l
0.63
52
306
54
359
1.76
2.75
1.6
1.9
238095661.26
443.32
pmol/l
0.49
42
285
8
19
4.37
2.71
1.0
1.1
—
—
—
0
0
12
43
2.94
2.71
1.3
1.5
—
—
—
0
0
88
671
1.69
2.71
5.2
4.0
0.00
0.00
estimate
-0.00
21
137
64
449
1.71
2.68
2.1
2.6
—
—
—
0
0
89
686
1.67
2.59
5.3
3.9
0.00
0.00
estimate
-0.00
18
125
25
132
2.06
2.53
1.3
1.6
—
—
—
0
0
153
1415
2.86
2.49
29.8
20.1
83.77
83.40
umol/l
0.05
153
1415
148
1333
2.47
2.46
5.6
5.3
6.03
6.10
mmol/l
0.22
137
1190
18
84
2.29
2.46
3.8
2.9
—
—
—
0
0
153
1417
2.82
2.34
15.2
11.4
22.46
24.37
u/l
1.42
145
1354
22
116
2.04
2.24
4.3
4.0
88.47
81.38
ng/l
0.15
17
102
5
9
5.69
2.23
2.6
2.2
—
—
—
0
0
86
677
1.58
2.16
6.9
5.2
0.00
0.00
estimate
-0.00
20
128
18
89
2.15
2.16
3.7
8.9
26.03
25.00
mmol/l
1.08
18
89
5
10
5.12
2.08
1.6
2.2
—
—
—
0
0
57
410
1.61
2.08
4.0
3.3
—
—
—
0
0
69
521
1.57
2.04
2.3
2.7
171.60
167.67
ug/l
0.04
61
464
14
65
2.26
1.94
1.3
1.4
—
—
—
0
0
25
147
1.83
1.88
3.5
2.9
58.74
71.51
e9/l
0.88
20
119
9
35
2.66
1.83
2.9
4.0
5.03
4.94
kpa
—
9
35
9
35
2.66
1.83
2.9
4.0
7.96
8.16
kpa
—
9
35
43
300
1.59
1.75
5.6
4.5
1.02
1.02
kg/l
—
7
46
20
112
1.90
1.74
8.4
4.2
—
—
—
0
0
69
539
1.49
1.68
5.3
3.9
77.11
90.84
e6/l
0.14
55
394
11
49
2.34
1.67
6.8
4.8
20.21
31.34
mg/l
1.10
11
37
51
376
1.52
1.62
5.3
3.6
—
—
—
0
0
62
477
1.49
1.61
4.7
3.4
19.54
63.86
e6/l
1.26
53
368
6
20
3.08
1.59
1.5
1.3
—
—
—
0
0
5
15
3.40
1.53
2.8
1.3
—
—
—
0
0
6
21
2.93
1.52
1.7
2.2
87.55
89.99
%
—
6
21
57
438
1.47
1.47
4.2
3.3
0.11
0.36
e6/l
2.76
52
329
25
159
1.68
1.45
1.4
1.2
520.00
436.76
titre
—
8
37
28
184
1.63
1.44
8.9
8.1
1.30
1.58
mmol/l
0.14
22
152
9
41
2.26
1.39
2.9
4.0
7.43
7.42
ph
—
9
36
9
41
2.26
1.39
1.2
1.9
—
—
—
0
0
31
214
1.56
1.31
1.1
1.3
90.82
44.84
iu/ml
0.37
17
65
9
44
2.11
1.29
1.4
1.1
0.21
0.24
g/l
—
9
44
10
49
2.11
1.25
7.4
4.7
39.47
228.19
mg/l
—
10
36
8
37
2.22
1.23
7.3
5.6
—
—
—
0
0
5
19
2.68
1.22
1.2
1.5
—
—
nmol/l
—
0
0
13
72
1.88
1.19
1.4
1.7
1.49
1.66
g/l
0.25
13
63
49
383
1.40
1.12
6.7
4.3
0.00
0.00
estimate
-0.00
18
125
31
223
1.48
1.09
2.2
2.6
18.89
23.38
%
1.07
21
190
19
122
1.63
1.08
7.4
4.1
—
—
—
0
0
9
46
2.01
1.05
1.6
1.2
1.19
1.12
g/l
—
9
46
9
48
1.93
1.02
1.7
3.0
23.77
25.17
mmol/l
—
9
48
19
126
1.58
0.96
3.1
4.5
1.22
1.22
mmol/l
0.03
19
110
40
310
1.39
0.96
2.0
1.8
1.28
1.47
mg/l
0.26
31
246
6
115
0.50
0.86
1.5
1.5
—
—
—
0
0
8
45
1.82
0.85
1.1
1.2
—
—
—
0
0
7
122
0.55
0.82
1.3
1.4
—
—
—
0
0
108
983
1.30
0.81
5.4
4.6
—
—
—
0
0
6
33
1.85
0.80
1.0
1.7
—
—
—
0
0
38
301
1.34
0.80
4.7
4.1
—
—
—
0
0
12
75
1.65
0.77
1.5
3.4
—
—
—
0
0
6
34
1.79
0.77
3.7
3.3
—
—
—
0
0
0
28
0.00
0.77
0.0
1.6
—
6.13
—
0
9
66
569
1.27
0.75
2.2
2.3
—
—
—
0
0
7
38
1.88
0.74
2.3
3.3
—
—
—
0
0
5
25
2.03
0.73
1.2
1.2
—
—
—
0
0
5
26
1.95
0.71
1.4
3.6
—
—
—
0
0
7
42
1.70
0.69
1.6
2.8
8.84
8.02
kpa
—
7
42
5
27
1.88
0.69
5.4
2.0
10.09
4.55
e9/l
—
5
27
24
181
1.38
0.68
2.5
4.2
6.51
65.83
ug/l
0.77
19
153
19
255
0.71
0.67
1.3
1.5
2.42
2.74
g/l
0.33
13
144
5
28
1.81
0.66
2.2
3.3
—
—
—
0
0
23
173
1.38
0.66
1.6
1.7
—
—
—
0
0
5
29
1.75
0.64
6.0
2.9
68.60
57.69
%
—
5
29
77
687
1.23
0.62
5.2
5.8
2.23
2.73
ug/l
0.42
69
606
21
158
1.38
0.61
1.8
2.4
7.34
6.16
ug/l
0.20
16
137
6
35
1.74
0.58
1.7
3.1
—
—
—
0
0
24
190
1.31
0.52
1.3
1.3
—
—
—
0
0
16
119
1.38
0.50
1.3
1.5
—
—
—
0
0
44
378
1.23
0.50
3.1
3.1
7164.89
10231.26
umol/l
0.16
38
313
11
78
1.44
0.44
1.2
1.1
—
—
—
0
0
11
79
1.42
0.42
1.1
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
5
78
0.63
0.36
2.0
3.4
43.40
449.91
u/ml
—
5
68
11
82
1.37
0.35
2.5
2.6
—
—
—
0
0
24
201
1.23
0.35
1.1
1.3
54.27
17.74
u/ml
—
6
67
40
355
1.17
0.32
8.0
6.7
—
—
—
0
0
7
97
0.71
0.32
1.7
1.9
1.38
1.35
g/l
—
7
87
7
53
1.34
0.31
1.4
1.9
—
—
—
0
0
22
186
1.21
0.30
1.2
1.5
—
—
—
0
0
14
112
1.27
0.29
1.3
1.5
—
—
—
0
0
53
486
1.14
0.28
3.5
3.3
5.84
7.40
mmol/l
2.12
44
396
17
203
0.82
0.28
1.2
1.3
—
—
—
0
0
53
488
1.13
0.26
4.2
3.3
2518.72
180.93
mg/l
0.71
35
316
56
599
0.90
0.22
16.7
11.2
0.00
0.00
e9/l
0.50
49
505
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
1.17
—
0
6
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
68.57
—
0
7
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
3.85
—
0
5
0
13
0.00
0.21
0.0
2.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
14
165
0.83
0.20
1.4
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
55
515
1.10
0.20
3.8
3.9
7.95
6.40
mg/mmol
0.19
36
316
28
252
1.13
0.19
4.2
3.2
1.63
1.76
e6/l
0.05
16
147
8
68
1.19
0.17
1.0
1.2
—
—
—
0
0
8
70
1.15
0.16
1.1
1.2
180.90
148.56
u/ml
—
8
64
14
121
1.17
0.15
3.9
3.6
—
—
—
0
0
37
394
0.92
0.13
2.9
3.3
0.75
0.78
ug/l
0.08
29
284
5
43
1.17
0.10
1.4
3.4
—
—
—
0
0
6
72
0.83
0.08
1.2
1.3
—
—
—
0
0
7
82
0.85
0.07
1.4
1.3
—
—
—
0
0
37
384
0.95
0.06
2.5
3.5
—
—
—
0
0
10
110
0.90
0.05
1.4
1.4
—
—
—
0
0
15
141
1.07
0.03
1.3
1.5
—
—
—
0
0
25
241
1.04
0.03
1.8
1.8
—
—
—
0
0
35
341
1.03
0.02
1.3
1.3
—
—
—
0
0
114
1132
1.02
0.01
32.7
19.9
15.95
15.37
%
0.40
114
1119
15
144
1.05
0.00
4.7
4.3
6.13
5.84
kpa
0.71
15
139
14
136
1.03
0.00
6.6
9.7
—
—
—
0
0
16
158
1.01
0.00
3.0
3.1
6.31
10.98
umol/l
1.51
16
140
10
98
1.02
0.00
5.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
86
0.93
-0.00
1.8
2.8
0.66
0.70
%
—
8
86
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
1875.00
—
0
6
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
89
0.89
-0.00
1.8
2.9
0.96
1.27
%
—
8
89
0
6
0.00
-0.00
0.0
1.2
—
226.17
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
19.27
—
0
6
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint I9_CEREBAMY and mortality.

Females

Parameter HR [95% CI] p-value
I9_CEREBAMY 3.173 [1.99, 5.06] < 0.001
Birth year 0.996 [0.99, 1.0] 0.346

During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 255 females with I9_CEREBAMY died.

Males

Parameter HR [95% CI] p-value
I9_CEREBAMY 3.149 [2.01, 4.93] < 0.001
Birth year 0.989 [0.98, 1.0] 0.018

During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 278 males with I9_CEREBAMY died.

Mortality risk

Mortality risk for people of age

years, who have I9_CEREBAMY.

N-year risk Females Males
1 0.33% 0.564%
5 2.108% 3.809%
10 4.917% 9.085%
15 9.426% 16.378%
20 15.814% 27.056%

Relationships between endpoints

↥

Index endpoint: I9_CEREBAMY – Cerebral amyloid angiopathy

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data