cerebral amyloid angiopathy: Hereditary cerebral hemorrhage with amyloidosis (HCHWA) describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
124 |
4. Check minimum number of eventsNone |
124 |
5. Include endpointsNone |
124 |
6. Filter based on genotype QC (FinnGen only) |
124 |
Control definitions (FinnGen only)
- Control exclude
- I9_CEREBVASC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Cerebral amyloid angiopathy
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases
- Neurological diseases, wide definition
- Cardiovascular diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 791 | 364 | 421 |
| Only index persons | 742 | 344 | 398 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 74.51 | 75.07 | 73.97 |
| Only index persons | 74.47 | 75.07 | 73.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 124 | 48 | 76 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 73.58 | 72.84 | 74.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 108
- Matched controls
- 1080
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I68.0*E85.9
ICD-10 Finland
Cerebral amyloid angiopathy
+∞
89.4
73
*
I68.0
ICD-10 Finland
Cerebral amyloid angiopathy
+∞
62.8
54
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
410.4
31.6
30
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
338.2
27.0
26
*
AA1AD
NOMESCO Finland
CT of head and brain
9.7
24.6
62
131
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
+∞
23.8
22
*
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
+∞
20.5
19
*
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
+∞
19.3
18
*
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
+∞
19.3
18
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
14.5
18.0
31
29
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
6.5
14.4
43
100
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
12.5
13.3
24
24
E85.9
ICD-10 Finland
Amyloidosis, unspecified
146.3
12.7
13
*
R4120
NOMESCO Finland
Occupational therapy
15.1
11.7
19
15
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
9.1
10.9
23
31
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
+∞
10.6
10
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
33.4
9.6
12
*
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
+∞
9.5
9
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
11.5
8.9
16
16
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
30.3
8.7
11
*
K90
ICPC
Stroke/cerebrovascular accident
24.2
8.2
11
5
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
5.3
7.8
24
55
R51.80
ICD-10 Finland
Headache
5.3
7.5
23
52
XA800
NOMESCO Finland
Neuropsychological investigation
17.3
7.4
11
7
N03AF02
ATC
oxcarbazepine; oral
13.3
7.3
12
10
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
21.8
7.3
10
5
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
32.4
7.3
9
*
N03AX14
ATC
levetiracetam; systemic
32.4
7.3
9
*
P20
ICPC
Memory disturbance
4.0
6.9
29
91
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
19.4
6.4
9
5
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
19.4
6.4
9
5
R41.0
ICD-10 Finland
Disorientation, unspecified
13.6
6.2
10
8
SPAT1229
SPAT
Assessment of need for aid
5.0
6.1
19
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
90
317
7.71
26.50
3.1
1.9
u/l
162.4
260.8
0.73
90
290
(3019473) Protein [Mass/volume] in Cerebral spinal fluid
22
18
14.64
22.70
1.4
1.2
mg/l
714.7
626.9
0.17
22
18
(3044290) Cell count panel - Cerebral spinal fluid
18
11
18.97
21.54
1.3
1.5
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
93
569
3.54
8.95
9.2
7.2
mmol/l
1.2
1.2
0.67
72
467
(3016914) Bacteria identified in Cerebral spinal fluid by Culture
12
6
21.93
8.65
1.1
1.2
—
—
—
0
0
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
87
519
3.27
8.58
6.9
6.4
mmol/l
1.2
1.2
0.02
76
458
(3019309) Folate [Moles/volume] in Red Blood Cells
52
233
3.12
8.51
2.2
1.8
nmol/l
976.0
1260.9
1.79
41
175
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
80
466
3.02
8.03
2.5
2.1
pmol/l
79.7
93.9
2.34
51
249
(3013707) Erythrocyte sedimentation rate by Westergren method
109
777
4.33
7.47
5.4
4.1
mm/h
14.6
13.0
0.44
101
698
(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid
10
5
21.56
7.26
1.2
1.2
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
43
187
2.99
7.25
2.2
1.9
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
104
727
3.67
7.17
6.5
4.4
—
—
—
0
0
(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid
11
8
14.92
7.03
1.1
1.1
—
—
—
0
0
(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid
11
8
14.92
7.03
1.1
1.1
—
—
—
0
0
(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing
10
6
17.95
6.87
1.1
1.0
—
—
—
0
0
(3021960) Folate [Moles/volume] in Serum or Plasma
55
294
2.56
6.05
1.8
1.6
nmol/l
16.2
21.9
2.82
46
239
(3026008) Bacteria identified in Urine by Culture
59
336
2.44
5.57
4.2
3.0
—
—
—
0
0
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
110
856
3.52
5.15
8.6
8.0
u/l
75.2
80.5
1.05
103
792
(42870588) Differential panel, method unspecified - Blood
58
339
2.34
5.04
8.0
5.7
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
18
58
3.46
4.86
11.9
11.6
—
—
—
0
0
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
68
430
2.29
4.86
2.7
2.3
nmol/l
83.2
80.1
0.37
61
365
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
119
1021
5.10
4.73
25.4
16.2
mg/l
25.8
25.7
0.01
103
825
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
117
988
4.26
4.73
6.4
6.7
mmol/mol
40.6
40.9
0.12
106
898
(3016018) Differential panel - Cerebral spinal fluid
7
5
14.71
4.63
1.1
1.2
—
—
—
0
0
(3019225) pH of Specimen
26
108
2.78
4.60
3.7
4.0
—
—
—
0
0
(3015377) Calcium [Moles/volume] in Serum or Plasma
62
385
2.22
4.55
4.3
3.7
mmol/l
2.3
2.4
0.68
49
337
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
15
45
3.65
4.49
1.5
2.0
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
14
40
3.82
4.48
1.6
1.7
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
19
67
3.17
4.46
1.6
1.8
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
74
497
2.21
4.43
8.4
9.1
inr
1.2
1.3
0.08
26
147
(3004588) Protein electrophoresis panel - Serum or Plasma
22
87
2.86
4.25
3.8
2.2
—
—
—
0
0
(3013115) Eosinophils [#/volume] in Blood
74
507
2.14
4.09
7.7
6.0
e9/l
0.2
0.2
2.65
65
446
(3022096) Basophils/100 leukocytes in Blood
66
436
2.10
3.98
8.1
6.0
%
0.7
0.6
0.24
59
399
(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
10
25
4.26
3.78
1.7
2.4
%
85.4
79.1
—
10
25
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
116
1003
3.42
3.71
5.2
5.0
mmol/l
4.2
4.4
1.51
106
899
(3019198) Lymphocytes [#/volume] in Blood
72
500
2.05
3.70
8.0
5.7
e9/l
1.4
1.8
3.08
65
446
(3006315) Basophils [#/volume] in Blood
71
493
2.03
3.63
7.6
5.7
e9/l
0.0
0.0
0.32
64
427
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
96
746
2.27
3.62
3.7
3.8
pmol/l
15.5
15.0
0.87
87
650
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
115
991
3.21
3.59
5.2
4.9
mmol/l
1.4
1.5
0.88
106
881
(3006504) Eosinophils/100 leukocytes in Blood
66
450
2.00
3.51
8.6
6.0
%
2.4
2.9
1.34
59
412
(3019069) Monocytes/100 leukocytes in Blood
66
453
1.98
3.42
9.4
6.3
%
9.4
9.1
0.24
59
417
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
112
941
2.97
3.40
4.9
4.5
mu/l
1.9
2.0
0.35
103
814
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
117
1031
3.39
3.35
5.8
5.6
mmol/l
2.5
2.6
0.88
107
917
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
44
265
2.02
3.28
1.7
1.9
pmol/l
294118066.5
455.1
0.49
34
213
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
113
962
2.97
3.18
4.5
4.4
mmol/l
1.2
1.3
0.59
102
851
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
38
219
2.06
3.18
6.8
3.3
ng/l
460.8
169.0
0.31
32
185
(3002030) Lymphocytes/100 leukocytes in Blood
66
461
1.92
3.18
9.2
6.1
%
21.1
26.0
3.11
60
418
(3013650) Neutrophils [#/volume] in Blood by Automated count
80
597
1.96
3.14
9.5
10.0
e9/l
4.8
4.2
0.50
70
525
(3021788) Differential panel - Synovial fluid
8
16
5.26
3.10
1.6
1.1
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
26
130
2.27
3.09
2.5
1.8
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
52
340
1.91
3.02
4.4
4.4
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
10
30
3.54
2.97
1.1
1.5
—
—
—
0
0
(3018418) pH of Serum or Plasma
53
351
1.89
2.94
4.7
4.3
ph
7.4
7.4
0.19
15
71
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
26
133
2.21
2.93
2.4
1.9
—
—
—
0
0
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
44
275
1.93
2.90
2.0
2.0
mg/l
2.5
3.2
1.67
36
235
(3018010) Neutrophils/100 leukocytes in Blood
64
452
1.86
2.90
8.8
5.8
%
64.1
58.2
3.51
58
413
(3033658) Prothrombin time (PT) actual/Normal
41
251
1.95
2.87
4.5
4.2
%
91.7
86.4
0.92
41
246
(3001604) Monocytes [#/volume] in Blood
68
491
1.85
2.85
7.9
5.7
e9/l
0.6
0.6
0.01
63
419
(3013512) EKG study
57
390
1.85
2.84
4.3
4.3
—
—
—
0
0
(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation
18
79
2.50
2.83
1.5
3.9
mmol/l
2.0
2.2
0.07
13
61
(3023410) Appearance of Cerebral spinal fluid
5
6
8.61
2.77
1.4
1.3
—
—
—
0
0
(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay
5
6
8.61
2.77
1.0
1.0
—
—
—
0
0
(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay
5
6
8.61
2.77
1.0
1.2
—
—
—
0
0
(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
12
43
2.98
2.73
5.4
2.2
g/l
2.6
3.0
—
7
34
(40761511) CBC panel - Blood by Automated count
117
1049
3.04
2.71
23.1
15.9
—
—
—
0
0
(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma
27
145
2.10
2.69
4.6
5.2
%
30.7
34.0
0.77
21
88
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
41
257
1.89
2.65
2.3
2.6
—
—
—
0
0
(44816559) Phosphatidylethanol [Mass/volume] in Blood
7
15
4.88
2.63
1.0
1.1
—
—
—
0
0
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
53
363
1.80
2.57
2.3
2.5
u/l
57.8
58.2
0.04
48
335
(3014271) Vancomycin [Susceptibility]
5
7
7.38
2.57
2.6
2.1
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
11
39
3.00
2.55
1.1
1.6
—
—
—
0
0
(3026782) Osmolality of Urine
38
239
1.85
2.41
3.8
2.8
mosm/kgh2o
573.7
559.4
0.17
33
203
(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
12
47
2.72
2.35
5.4
2.1
g/l
6.9
7.8
—
7
36
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
66
495
1.71
2.26
4.4
4.6
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
58
421
1.71
2.23
4.5
3.3
—
—
—
0
0
(3023520) Reticulocytes [#/volume] in Blood
21
111
2.07
2.17
4.0
3.0
e9/l
59.6
74.0
0.76
16
88
(46235355) HIV 1 and 2 tests - Meaningful Use set
19
98
2.11
2.09
1.2
1.5
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
49
346
1.69
2.05
2.1
2.6
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
64
487
1.65
2.00
4.8
4.1
ng/l
28.5
48.6
1.46
56
391
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
27
161
1.87
1.99
1.1
1.2
iu/ml
97.5
46.4
0.36
15
46
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
63
478
1.65
1.99
2.5
2.2
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
53
389
1.63
1.88
2.3
2.7
ug/l
190.2
173.7
0.15
46
344
(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma
9
35
2.69
1.84
7.9
5.3
mg/l
19.9
30.9
—
9
24
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
11
47
2.47
1.83
5.8
2.1
—
—
—
0
0
(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
11
47
2.47
1.83
5.8
2.1
g/l
3.0
3.7
—
6
34
(36304419) Bacteria [Presence] in Urine
44
311
1.64
1.80
4.4
3.1
—
—
—
0
0
(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
118
1092
2.66
1.79
15.2
11.5
u/l
22.5
24.6
1.20
110
1039
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
8
30
2.78
1.75
1.3
1.2
—
—
—
0
0
(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability
5
13
3.96
1.73
1.4
1.5
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
6
19
3.26
1.68
1.2
1.1
—
—
—
0
0
(3019150) Specific gravity of Urine by Refractometry
33
221
1.67
1.64
5.3
4.5
kg/l
1.0
1.0
—
6
30
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
14
71
2.10
1.61
4.0
10.2
mmol/l
25.8
24.6
1.02
14
71
(3020564) Creatinine [Moles/volume] in Serum or Plasma
117
1088
2.33
1.57
29.6
19.9
umol/l
86.4
83.0
0.49
117
1088
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
5
15
3.43
1.54
1.0
1.5
—
—
—
0
0
(3028271) Lactate [Moles/volume] in Capillary blood
6
21
2.95
1.52
1.7
2.5
mmol/l
2.4
1.5
—
6
21
(3002582) Erythrocytes [#/volume] in Urine
48
360
1.54
1.49
5.3
3.3
e6/l
18.8
50.4
1.28
43
276
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
112
1021
2.00
1.48
5.5
5.3
mmol/l
6.0
6.1
0.29
103
901
(3007853) Bacteria identified in Skin by Aerobe culture
21
127
1.79
1.48
1.6
1.7
—
—
—
0
0
(3037756) Immunofixation for Serum or Plasma
7
29
2.50
1.41
1.1
1.5
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
53
411
1.51
1.40
5.9
3.7
e6/l
92.2
104.9
0.10
45
296
(3009445) Proteinase 3 Ab [Units/volume] in Serum
10
47
2.23
1.38
1.3
1.1
—
—
—
0
0
(3030905) Polymorphonuclear cells [#/volume] in Blood
5
17
3.02
1.37
5.4
1.8
e9/l
10.1
4.7
—
5
17
(3009261) Glucose [Presence] in Urine by Test strip
66
537
1.49
1.37
5.2
3.8
estimate
0.0
0.0
0.00
13
102
(3022313) Gas panel - Capillary blood
12
62
2.04
1.33
1.5
3.7
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
5
18
2.85
1.29
1.2
1.1
—
—
—
0
0
(3034860) Kappa light chains.free [Mass/volume] in Serum
8
35
2.37
1.29
8.8
5.3
mg/l
29.8
106.6
—
8
24
(3029937) Albumin [Presence] in Urine by Test strip
41
306
1.51
1.28
6.3
4.1
estimate
0.0
0.0
0.00
13
106
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
5
19
2.70
1.23
6.0
3.2
%
68.6
56.7
—
5
19
(3035350) Ketones [Presence] in Urine by Test strip
64
527
1.44
1.20
5.1
3.8
estimate
0.0
0.0
0.00
14
111
(3049717) Cytology report of Urine Cyto stain
11
58
1.98
1.16
3.2
2.8
—
—
—
0
0
(3017766) Complement C4 [Mass/volume] in Serum or Plasma
7
30
2.41
1.14
1.6
1.2
g/l
0.2
0.2
—
7
30
(3011397) Hemoglobin [Presence] in Urine by Test strip
32
232
1.51
1.13
4.8
3.7
—
—
—
0
0
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
24
163
1.59
1.12
2.2
2.5
%
20.8
23.7
0.51
17
138
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
7
31
2.33
1.12
1.3
1.2
—
—
—
0
0
(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma
20
130
1.64
1.11
2.1
4.7
ug/l
7.5
87.7
0.74
15
110
(3024928) Oxygen saturation in Venous blood
5
21
2.44
1.10
3.8
2.3
—
—
—
0
0
(3000620) Complement C3 [Mass/volume] in Serum or Plasma
7
32
2.26
1.10
1.7
1.3
g/l
1.2
1.1
—
7
32
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
51
412
1.40
1.03
5.6
4.1
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
31
229
1.47
1.00
2.0
1.9
mg/l
1.3
1.4
0.06
25
188
(3021601) Nitrite [Presence] in Urine by Test strip
63
530
1.38
0.99
6.5
5.0
estimate
0.0
0.0
0.00
15
109
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
0
29
0.00
0.99
0.0
1.6
—
—
—
0
0
(3026493) Urate [Moles/volume] in Serum or Plasma
37
284
1.43
0.98
3.4
3.1
umol/l
364.0
6630.1
1.27
32
231
(21494755) Public health laboratory ask at order entry panel
0
31
0.00
0.98
0.0
1.4
—
—
—
0
0
(40760888) Immunoglobulin light chains.free panel - Serum
6
27
2.28
0.95
9.0
6.2
—
—
—
0
0
(3027315) Oxygen [Partial pressure] in Blood
6
32
1.92
0.83
3.2
4.2
kpa
7.3
8.2
—
6
32
(3013290) Carbon dioxide [Partial pressure] in Blood
6
32
1.92
0.83
3.2
4.2
kpa
5.1
4.9
—
6
32
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
21
149
1.49
0.82
1.1
1.3
u/ml
64.9
9.4
—
5
45
(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma
18
124
1.53
0.80
1.7
2.3
ug/l
4.8
5.8
0.23
13
107
(3037522) Nuclear Ab [Titer] in Serum
18
125
1.51
0.78
1.5
1.2
titre
548.6
472.7
—
7
33
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
6
34
1.80
0.77
1.3
1.9
—
—
—
0
0
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
5
23
2.22
0.77
1.0
1.6
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
5
23
2.22
0.77
1.0
1.1
—
—
—
0
0
(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
20
144
1.46
0.74
5.3
4.6
u/l
224.3
246.7
0.75
20
137
(3012544) pH of Venous blood
16
110
1.52
0.73
5.9
3.4
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
5
91
0.53
0.70
1.4
1.4
—
—
—
0
0
(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood
15
104
1.50
0.66
2.9
4.9
mmol/l
1.2
1.2
0.45
15
90
(3052851) Hemolysis interference index of Serum or Plasma
5
29
1.75
0.64
1.4
3.4
—
—
—
0
0
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
49
419
1.28
0.62
2.4
3.3
ng/l
1970.5
1289.9
0.45
44
360
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
5
30
1.69
0.62
2.4
1.5
—
—
—
0
0
(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
(3014051) Protein [Presence] in Urine by Test strip
0
21
0.00
0.60
0.0
2.3
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
22
0.00
0.60
0.0
1.0
—
—
—
0
0
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
60
529
1.26
0.59
5.3
5.7
ug/l
2.1
2.7
0.40
54
461
(3012336) Haptoglobin [Mass/volume] in Serum or Plasma
8
54
1.51
0.58
1.6
1.6
g/l
1.1
1.6
—
8
46
(3022145) Colonoscopy Study observation
8
122
0.63
0.58
1.3
1.2
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
104
983
1.36
0.56
21.0
16.2
ml/min/173m2
72.5
73.4
0.19
89
818
(3010421) pH of Blood
6
37
1.65
0.56
3.2
3.9
ph
7.4
7.4
—
6
32
(36660697) Celiac disease serology panel - Serum
9
64
1.44
0.53
1.2
1.1
—
—
—
0
0
(3019060) Gas panel - Arterial blood
13
93
1.44
0.50
11.7
4.0
—
—
—
0
0
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
7
45
1.59
0.50
2.9
3.0
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
19
147
1.35
0.49
6.4
8.0
—
—
—
0
0
(3007164) IgA [Mass/volume] in Serum or Plasma
14
186
0.72
0.49
1.4
1.5
g/l
2.5
3.0
—
8
100
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
23
184
1.31
0.48
4.7
3.1
e6/l
1.7
1.0
0.34
15
106
(40761536) Microorganisms panel - Urine sediment
14
103
1.40
0.47
6.8
4.1
—
—
—
0
0
(3044889) 12 lead EKG panel
82
760
1.23
0.47
5.0
4.5
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
47
414
1.22
0.44
4.1
4.9
%
18.4
21.9
1.11
21
227
(3014218) Bicarbonate [Moles/volume] standard in Arterial blood
8
55
1.49
0.44
8.0
15.5
mmol/l
23.5
24.9
—
8
49
(40758558) Short blood count panel - Blood
32
271
1.24
0.43
8.4
6.5
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
18
141
1.32
0.43
1.2
1.5
—
—
—
0
0
(1616796) Gas panel - Central venous blood
5
32
1.59
0.42
2.8
3.4
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
35
300
1.23
0.42
5.0
3.5
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
92
868
1.23
0.42
31.1
16.8
%
36.5
39.6
1.27
52
523
(3021879) Hepatitis B virus core Ab [Presence] in Serum
8
59
1.38
0.42
1.0
1.4
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
5
33
1.54
0.42
1.4
1.9
—
—
—
0
0
(3008295) Osmolality of Serum or Plasma
0
15
0.00
0.41
0.0
1.1
—
269.8
—
0
9
(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
(40768795) Lymph node Pathology biopsy report
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
(3017044) Thyrotropin receptor Ab [Units/volume] in Serum
0
19
0.00
0.39
0.0
1.8
—
4.9
—
0
7
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
9
70
1.31
0.37
1.9
1.3
—
—
—
0
0
(3022621) pH of Urine by Test strip
9
71
1.29
0.37
5.0
2.2
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
12
92
1.34
0.33
1.2
1.4
—
—
—
0
0
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
24
203
1.23
0.33
4.0
2.8
e6/l
0.6
1.1
0.91
16
122
(3002385) Erythrocyte distribution width [Ratio]
79
835
0.85
0.33
36.3
20.1
%
14.1
13.9
0.47
79
821
(3000991) Gas panel - Venous blood
13
102
1.31
0.31
6.8
10.0
—
—
—
0
0
(3002256) Pathology report gross observation
17
139
1.26
0.31
1.4
1.3
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
12
150
0.78
0.29
1.1
1.2
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
24
207
1.20
0.28
4.4
5.7
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
10
77
1.32
0.27
1.8
1.6
—
—
—
0
0
(3028026) IgM [Mass/volume] in Serum or Plasma
5
71
0.69
0.27
1.8
2.0
g/l
1.2
1.6
—
5
62
(3045414) Leukocytes [Presence] in Urine
5
39
1.29
0.23
1.6
1.9
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
47
435
1.13
0.22
2.2
2.3
—
—
—
0
0
(3021589) Normoblasts [#/volume] in Blood
44
475
0.89
0.22
16.5
11.6
e9/l
0.0
0.0
0.50
39
406
(40761535) Cells panel - Urine sediment
11
89
1.26
0.21
4.3
3.6
—
—
—
0
0
(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
(3039162) Centromere protein B Ab [Units/volume] in Serum
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
(3017569) Oxygen content in Arterial blood
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
(3038026) Centromere Ab [Units/volume] in Serum
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
(3001893) Eosinophils/100 leukocytes in Pleural fluid
0
10
0.00
0.21
0.0
1.4
—
1.4
—
0
5
(3005532) Lymphocytes/100 leukocytes in Pleural fluid
0
10
0.00
0.21
0.0
1.6
—
60.2
—
0
5
(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
1.7
—
14.1
—
0
10
(3038177) Helicobacter pylori Ab [Presence] in Serum
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3009508) Creatinine [Moles/volume] in Urine
39
358
1.13
0.21
3.9
3.3
mmol/l
6.1
7.4
1.20
33
289
(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(40759836) Histone Ab [Presence] in Serum by Immunoblot
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(3027544) Mycobacterium sp identified in Sputum by Organism specific culture
0
14
0.00
0.20
0.0
4.7
—
—
—
0
0
(3004616) Nuclear Ab [Presence] in Serum
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection
0
14
0.00
0.20
0.0
2.0
—
—
—
0
0
(3005322) IgE [Units/volume] in Serum or Plasma
6
51
1.19
0.19
1.2
1.3
u/ml
216.4
148.2
—
6
45
(3042936) Bacteria identified in Isolate by Culture
21
185
1.16
0.19
1.7
1.8
—
—
—
0
0
(3007628) Bicarbonate [Moles/volume] standard in Venous blood
6
52
1.16
0.19
4.7
2.5
mmol/l
25.2
24.2
—
6
46
(3012516) Albumin [Mass/volume] in Urine
39
360
1.12
0.19
4.8
3.3
mg/l
3145.8
55.7
0.77
28
236
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
17
147
1.18
0.19
6.1
3.8
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
7
59
1.20
0.18
2.7
2.6
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
41
381
1.11
0.18
4.3
4.2
mg/mmol
9.8
7.4
0.23
28
236
(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma
10
120
0.82
0.17
3.4
3.3
umol/l
6.3
9.6
—
10
107
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
9
79
1.15
0.15
8.6
11.8
%
0.5
0.6
—
9
79
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
9
79
1.15
0.15
8.4
11.6
%
0.9
1.4
—
9
79
(4010399)
7
87
0.79
0.15
1.3
1.3
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
10
86
1.18
0.11
1.3
1.5
—
—
—
0
0
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
28
297
0.93
0.09
2.7
3.0
ug/l
0.7
0.8
0.16
23
209
(40768443) Skin Pathology biopsy report
6
56
1.08
0.09
1.0
1.3
—
—
—
0
0
(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma
5
60
0.83
0.08
2.0
3.6
u/ml
43.4
79.2
—
5
51
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
7
66
1.06
0.08
1.6
2.2
%
1.0
1.3
—
7
66
(1761868) Lipid panel - Serum or Plasma
29
306
0.93
0.08
2.4
3.6
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
12
114
1.06
0.01
1.3
1.4
—
—
—
0
0
(4035726)
11
116
0.94
0.01
1.4
1.5
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
26
262
0.99
0.00
1.3
1.3
—
—
—
0
0
(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum
0
7
0.00
0.00
0.0
1.4
—
16.1
—
0
7
(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(4062490)
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3008536) Aspergillus sp Ab [Presence] in Serum
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma
9
92
0.98
0.00
2.2
2.3
u/l
33.0
34.1
—
9
75
(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
3.0
—
69.6
—
0
7
(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(44806420)
0
8
0.00
0.00
0.0
3.0
—
—
—
0
0
(40765096) Chromosome analysis panel by Banding
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3029075) Extractable nuclear Ab panel - Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3037692) Legionella sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3012565) Volume of 24 hour Urine
0
5
0.00
0.00
0.0
2.8
—
2010.0
—
0
5
(44813793)
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3010726) Horse dander IgE Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum
0
9
0.00
0.00
0.0
2.8
—
—
—
0
0
(3011544) Albumin [Mass/volume] in Pleural fluid
0
6
0.00
0.00
0.0
1.0
—
19.3
—
0
6
(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.3
—
1201.1
—
0
8
(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(1617658) Protocol used for examination of sentinel lymph nodes
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
6
62
0.97
0.00
1.5
1.3
—
—
—
0
0
(3032773) Endomysium IgG Ab [Titer] in Serum
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3025130) Human papilloma virus identified in Specimen
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3024263) Appearance of Synovial fluid
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3044242) Glucose [Moles/volume] in Arterial blood
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
(3037556) Urate [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
5.8
—
245.4
—
0
8
Mortality – FinRegistry
↥Association
Association between endpoint I9_CEREBAMY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CEREBAMY | 3.173 [1.99, 5.06] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.346 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 255 females with I9_CEREBAMY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CEREBAMY | 3.149 [2.01, 4.93] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 278 males with I9_CEREBAMY died.
Mortality risk
Mortality risk for people of age
years, who have I9_CEREBAMY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.33% | 0.564% |
| 5 | 2.108% | 3.809% |
| 10 | 4.917% | 9.085% |
| 15 | 9.426% | 16.378% |
| 20 | 15.814% | 27.056% |
Relationships between endpoints
↥Index endpoint: I9_CEREBAMY – Cerebral amyloid angiopathy
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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