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Hypertension, Pulmonary Arterial

DOID EFO Endpoint Browser PheWeb

I9_HYPTENSPUL

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I27.0
  • Hospital discharge: ICD-9 — 4160A
  • Hospital discharge: ICD-8 — 42600
  • Cause of death: ICD-10 — I27.0
  • Cause of death: ICD-9 — 4160A
  • Cause of death: ICD-8 — 42600

2 out of 7 registries used, show all original rules.

326

4. Check minimum number of events

None

326

5. Include endpoints

None

326

6. Filter based on genotype QC (FinnGen only)

315

Control definitions (FinnGen only)

Control exclude
I9_HYPERTENSION

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I27
Name in latin
Hypertensio pulmonalis primaria

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2950 1579 1316
Only index persons 1759 1100 659
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.04
Only index persons 0.03 0.04 0.03
Median age at first event (years)
Whole population 65.26 67.03 63.32
Only index persons 68.00 69.52 65.46

-FinnGen-

Key figures

All Female Male
Number of individuals 315 205 110
Unadjusted period prevalence (%) 0.06 0.07 0.05
Median age at first event (years) 61.69 60.54 63.85

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
326
Matched controls
3260
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I27.0
ICD-10 Finland
Primary pulmonary hypertension
+∞
307.7
305
*
G04BE03
ATC
sildenafil; oral
224.0
274.9
133
10
205
Kela drug reimbursment
Chronic hypertension
+∞
220.8
186
*
C03DA01
ATC
spironolactone; oral
22.0
172.3
162
140
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
340.3
169.0
158
9
B01AA03
ATC
warfarin; systemic
14.5
137.7
197
311
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
14.5
136.8
186
274
C03CA01
ATC
furosemide; systemic
16.7
135.0
253
559
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
16.8
114.0
111
97
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
488.8
106.9
101
*
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
213.9
104.2
103
7
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
10.6
102.9
168
298
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
52.5
90.8
53
12
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
9.0
89.2
173
365
I50.9
ICD-10 Finland
Heart failure, unspecified
10.0
88.2
132
207
C02KX04
ATC
macitentan; oral
+∞
86.4
79
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
15.4
76.2
73
60
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
8.4
73.4
126
227
R06.0
ICD-10 Finland
Dyspnoea
7.4
73.3
189
515
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
12.3
71.4
80
84
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
13.7
70.2
72
66
I50.0
ICD-10 Finland
Congestive heart failure
11.0
65.7
80
94
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
13.0
64.3
68
65
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
259.2
63.6
63
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
7.5
63.2
246
948
C01AA05
ATC
digoxin; systemic
8.8
62.8
94
143
J96.1
ICD-10 Finland
Chronic respiratory failure
21.2
62.4
49
27
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
20.5
54.3
43
24
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
14.6
52.4
50
40
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
15.5
52.2
48
36
WX872
NOMESCO Finland
Intensive care
13.6
52.0
52
45
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
11.7
51.3
57
58
A12BA01
ATC
potassium chloride; oral
23.1
49.4
37
18
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
8.0
45.9
71
110
C02KX01
ATC
bosentan; oral
+∞
44.8
42
*
G04BE08
ATC
tadalafil; oral
489.8
44.3
43
*
M04AA01
ATC
allopurinol; systemic
6.8
42.9
79
147
I48
ICD-10 Finland
Atrial fibrillation and flutter
5.0
42.6
130
381
C08CA02
ATC
felodipine; oral
11.9
39.2
42
40
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
14.3
38.9
37
29
WX740
NOMESCO Finland
Nitrogen oxide therapy
151.4
38.7
40
*
AN1
HP
Coronary angiography
6.8
37.5
67
120
GD1AD
NOMESCO Finland
Thorax CT examination
8.7
37.2
51
68
C08CA05
ATC
nifedipine; systemic
10.5
35.2
41
44
AP2
HP
Catheterization of the right side of the heart
100.9
33.5
36
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
7.5
33.4
52
80
XF622
NOMESCO Finland
Measurement of minute volume of heart
189.1
33.4
34
*
TPH04
NOMESCO Finland
Cathetrisation of vein
4.3
32.8
113
355
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.0
32.6
139
508
I10
ICD-10 Finland
Essential (primary) hypertension
3.9
32.4
170
715
C07AB07
ATC
bisoprolol; oral
3.9
32.4
199
930
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
7.7
32.4
49
73
XF404
NOMESCO Finland
Ambulatory ECG
6.3
30.7
58
109
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
+∞
30.7
29
*
Z3226
NOMESCO Finland
Physiotherapist
4.3
30.5
104
322
R4110
NOMESCO Finland
Physiotherapy
3.8
29.6
139
537
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.9
29.6
77
193
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
8.5
29.1
40
53
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
5.3
28.9
67
152
B01AC27
ATC
selexipag; oral
+∞
27.5
26
*
Z2446
NOMESCO Finland
Social worker
6.4
27.0
49
88
C08DB01
ATC
diltiazem; oral
8.7
26.9
36
46
TPH07
NOMESCO Finland
Cathetrisation of artery
5.2
26.6
62
141
C08CA01
ATC
amlodipine; oral
3.6
26.5
121
454
B01AC11
ATC
iloprost; inhalant, parenteral
+∞
26.4
25
*
383
Kela drug reimbursment
Selexipag
+∞
26.4
25
*
C02KX02
ATC
ambrisentan; oral
+∞
26.4
25
*
H02AB06
ATC
prednisolone; systemic
3.4
26.3
197
1003
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
8.3
26.0
36
48
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.1
25.8
90
280
A46
ICD-10 Finland
Erysipelas
4.4
25.1
74
203
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.1
25.0
84
254
103
Kela drug reimbursment
Diabetes, insulin-treated
3.8
24.8
98
332
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.4
24.2
131
542
XF400
NOMESCO Finland
ECG with 12 standard connections
3.9
24.1
88
282
ZX120
NOMESCO Finland
Intravenous
4.6
23.8
64
163
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.1
23.7
55
124
XG466
NOMESCO Finland
Sleep oxymetry
10.4
23.5
27
28
C09AA02
ATC
enalapril; systemic
4.5
23.4
67
179
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.7
23.3
92
310
B01AB05
ATC
enoxaparin; parenteral
3.2
22.9
139
613
ZXE30
NOMESCO Finland
More than five and less than seven hours
6.7
22.6
38
63
ZXE20
NOMESCO Finland
More than three and less than five hours
4.0
22.6
75
224
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.4
22.5
40
70
TFP20
NOMESCO Finland
Cardiodefibrillation
6.0
22.5
43
81
R04.0
ICD-10 Finland
Epistaxis
5.2
21.6
48
104
K93
ICPC
Pulmonary embolism
64.5
21.2
24
*
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
+∞
21.1
20
*
Z94.2
ICD-10 Finland
Lung transplant status
+∞
21.1
20
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.2
20.5
62
172
I25.1
ICD-10 Finland
Atherosclerotic heart disease
3.5
20.5
89
317
201
Kela drug reimbursment
Chronic cardiac insufficiency
5.4
20.3
43
89
XG410
NOMESCO Finland
Flow-volume spirometry
7.0
20.0
32
50
B01AC21
ATC
treprostinil; parenteral
+∞
20.0
19
*
334
Kela drug reimbursment
Treprostinil
+∞
20.0
19
*
L04AA06
ATC
mycophenolic acid; systemic
26.6
19.9
27
11
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
8.3
19.8
27
35
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.8
19.6
49
117
WX892
NOMESCO Finland
Monitored bed care
5.4
19.6
41
84
XF620
NOMESCO Finland
Examination of circulation with color method
49.2
19.5
23
5
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
5.6
19.4
39
77
K78
ICPC
Atrial fibrillation/flutter
4.8
19.2
47
110
207
Kela drug reimbursment
Chronic arrhythmias
3.6
19.0
77
261
C02KX05
ATC
riociguat; oral
+∞
18.9
18
*
Z3231
NOMESCO Finland
Registered nurse
3.0
18.8
116
506
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
201.1
18.7
19
*
A10AB05
ATC
insulin aspart; parenteral
6.2
18.4
33
58
Z2221
NOMESCO Finland
Medical doctor
2.9
18.4
119
532
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
6.8
18.3
30
48
ZXE40
NOMESCO Finland
More than seven and less than nine hours
14.9
18.2
30
22
GDG10
NOMESCO Finland
Bilateral transplantation of lung
+∞
17.9
17
*
GD2SN
NOMESCO Finland
Lung ventilation SPECT
39.1
17.8
22
6
C07AB02
ATC
metoprolol; systemic
3.4
17.5
77
274
A10BB12
ATC
glimepiride; oral
6.2
17.5
31
54
I27.1
ICD-10 Finland
Kyphoscoliotic heart disease
+∞
16.8
16
*
I50.1
ICD-10 Finland
Left ventricular failure
5.6
16.6
33
64
127
Kela drug reimbursment
Transplant complication
42.5
16.5
20
5
SPAT1262
SPAT
Handing over of treatment supplies
3.4
16.4
68
233
A10BH05
ATC
linagliptin; oral
7.5
16.3
24
34
M10.9
ICD-10 Finland
Gout, unspecified
5.9
16.0
30
55
C03AA03
ATC
hydrochlorothiazide; oral
5.7
15.9
31
59
R50.9
ICD-10 Finland
Fever, unspecified
3.3
15.9
72
260
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
4.9
15.9
37
83
R28
ICPC
Limited function/disability (R)
20.5
15.8
23
12
B01AB10
ATC
tinzaparin; parenteral
3.8
15.7
54
163
J01MA12
ATC
levofloxacin; systemic
3.0
15.5
83
330
L04AX01
ATC
azathioprine; systemic
6.2
15.2
27
47
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
6.9
15.1
24
37
K99
ICPC
Cardiovascular disease other
17.6
15.0
23
14
AP3
HP
Catheterization of the right and left side of the heart
59.6
14.9
17
*
S97
ICPC
Chronic ulcer skin
5.2
14.8
32
67
62
HP
Catheterization and pressure measurement of the right side of the heart
84.0
14.7
16
*
42600
ICD-8 Finland
Pulmonary heart disease, Cor pulmonale
+∞
14.7
14
*
GD1UN
NOMESCO Finland
Lung circulation SPECT
38.0
14.6
18
5
FB1BC
NOMESCO Finland
Extensive angiography of arteria pulmonalis
156.7
14.6
15
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.1
14.6
73
279
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.0
14.6
44
121
Z01.8
ICD-10 Finland
Other specified special examinations
2.8
14.4
94
415
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.8
14.3
27
50
C09BA02
ATC
enalapril and diuretics; systemic
6.9
13.8
22
34
T90
ICPC
Diabetes non-insulin dependent
3.0
13.8
72
281
A10BA02
ATC
metformin; oral
2.8
13.7
87
378
FBB20
NOMESCO Finland
Thrombendarterectomy of pulmonary artery in chronic obstruction
+∞
13.6
13
*
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
19.3
13.5
20
11
ZX108
NOMESCO Finland
Inhalation
22.3
13.5
19
9
TGC00
NOMESCO Finland
Bronchial lavation
10.7
13.2
25
25
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.7
13.0
45
136
C02AC05
ATC
moxonidine; oral
52.2
12.9
15
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.9
12.9
40
112
ZXD05
NOMESCO Finland
Urgent procedure
2.5
12.8
116
597
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
16.3
12.8
20
13
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.3
12.7
53
181
R03AC02
ATC
salbutamol; inhalant
2.4
12.7
198
1290
GD1FN
NOMESCO Finland
Lung ventilation isotope imaging
+∞
12.6
12
*
A10AE05
ATC
insulin detemir; parenteral
5.7
12.5
24
45
B01AB04
ATC
dalteparin; parenteral
4.8
12.4
29
65
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
19.0
12.2
18
10
R4190
NOMESCO Finland
Nutritional therapy
5.3
12.1
25
50
3AC01, ,
NOMESCO Finland
22.3
12.1
17
8
C08CA13
ATC
lercanidipine; oral
3.8
12.1
39
112
C01BD01
ATC
amiodarone; systemic
11.1
12.0
22
21
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.7
11.9
40
118
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
6.2
11.9
21
36
R5140
NOMESCO Finland
Monitoring the use of the aid
3.4
11.9
46
149
Z73.3
ICD-10 Finland
Stress, not elsewhere classified
15.4
11.9
19
13
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
4.5
11.8
30
72
P01BA02
ATC
hydroxychloroquine; oral
3.5
11.7
43
135
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
11.7
143
832
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.0
11.6
26
56
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
+∞
11.5
11
*
GD1BT
NOMESCO Finland
Biopsy of lung with X-ray guidance
+∞
11.5
11
*
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
11.5
11
*
PH7FT
NOMESCO Finland
Inmplantation of filter to inferior vena cava with radiological guidance
+∞
11.5
11
*
K82
ICPC
Pulmonary heart disease
+∞
11.5
11
*
L04AD02
ATC
tacrolimus; systemic
124.2
11.5
12
*
R02
ICPC
Shortness of breath/dyspnoea
3.0
11.5
58
221
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
12.4
11.5
20
17
A10AC01
ATC
insulin (human); parenteral
4.1
11.3
33
88
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
17.8
11.3
17
10
A10BB01
ATC
glibenclamide; oral
8.5
11.3
24
30
FB1AD
NOMESCO Finland
CT examination of arteria pulmonalis
13.4
11.3
19
15
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
4.5
11.3
28
66
G47.3
ICD-10 Finland
Sleep apnoea
2.7
11.2
69
292
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
20.9
11.2
16
8
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.0
11.2
54
200
J45.9
ICD-10 Finland
Asthma, unspecified
2.6
10.9
75
336
I20.99
ICD-10 Finland
Angina pectoris, unspecified
4.2
10.8
30
77
N02AX02
ATC
tramadol; systemic, rectal
2.2
10.7
147
888
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
113.5
10.5
11
*
4160A
ICD-9 Finland
Chronic pulmonary heart disease, Primary pulmonary hypertension
+∞
10.5
10
*
FB1AC
NOMESCO Finland
Angiography of arteria pulmonalis
+∞
10.5
10
*
4019X
ICD-9 Finland
Essential hypertension, Unspecified
+∞
10.5
10
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.4
10.4
27
66
A10AE04
ATC
insulin glargine; parenteral
4.1
10.4
29
75
WX882
NOMESCO Finland
High dependency care
8.3
10.3
22
28
C07AA07
ATC
sotalol; systemic
4.8
9.9
23
51
J01MA14
ATC
moxifloxacin; systemic
3.2
9.9
42
144
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
3.7
9.9
32
92
C02EA02, ,
ATC
27.0
9.9
13
5
XF402
NOMESCO Finland
ECG with work load test
3.2
9.8
41
140
N02AA05
ATC
oxycodone; systemic
2.5
9.6
73
342
C09AA05
ATC
ramipril; oral
2.4
9.5
78
377
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.9
9.5
48
182
M34.1
ICD-10 Finland
CR(E)ST syndrome
31.0
9.5
12
*
C01DA14
ATC
isosorbide mononitrate; oral
2.6
9.4
59
251
AA1AD
NOMESCO Finland
CT of head and brain
2.3
9.4
94
495
PH3BC
NOMESCO Finland
Extensive flebography of internal organs with X-ray
+∞
9.4
9
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.6
9.3
60
259
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.4
9.3
77
374
TLC00
NOMESCO Finland
Insertion of intrauterine device
4.5
9.3
23
54
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
5.0
9.2
20
42
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
7.8
9.1
20
27
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.4
9.1
23
55
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
37.8
9.1
11
*
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
3.2
9.1
37
124
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
4.1
9.0
25
64
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
9.0
124
739
D68.8
ICD-10 Finland
Other specified coagulation defects
19.3
9.0
13
7
A07AA09
ATC
vancomycin; oral
19.3
9.0
13
7
R03BB04
ATC
tiotropium bromide; inhalant
2.8
9.0
47
182
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
5.1
9.0
19
39
FL1AC
NOMESCO Finland
Left cardioangiography
11.1
8.9
16
15
L04AD01
ATC
ciclosporin; systemic
14.6
8.8
14
10
N18.8
ICD-10 Finland
Other chronic renal failure
14.6
8.8
14
10
WX725
NOMESCO Finland
Noninvasive ventilation
4.2
8.8
24
61
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.9
8.7
43
161
C09DA06
ATC
candesartan and diuretics; oral
4.8
8.7
20
44
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
4.0
8.7
25
66
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.1
8.7
107
611
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
8.6
136
851
A10BH01
ATC
sitagliptin; oral
3.5
8.6
30
91
ZXE00
NOMESCO Finland
One hour or less
2.0
8.5
136
852
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
7.0
8.5
20
30
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
7.0
8.5
20
30
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.4
8.5
32
102
C09CA01
ATC
losartan; oral
2.4
8.5
68
325
K29
ICPC
Cardiovascular sympt/complt other
4.9
8.5
19
41
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.5
8.4
58
258
N19
ICD-10 Finland
Unspecified kidney failure
8.9
8.4
17
20
I28.9
ICD-10 Finland
Disease of pulmonary vessels, unspecified
+∞
8.4
8
*
J01FF01
ATC
clindamycin; systemic
2.2
8.3
89
480
JN4AD
NOMESCO Finland
Body CT examination
2.9
8.2
40
149
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.8
8.2
45
179
D64.9
ICD-10 Finland
Anaemia, unspecified
2.8
8.2
43
167
RK110, ,
NOMESCO Finland
17.7
8.1
12
7
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.3
8.0
67
325
SPAT1255
SPAT
Intravenous administration of medicine
3.7
8.0
26
75
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.8
8.0
41
157
R03AK08
ATC
formoterol and beclometasone; inhalant
4.2
7.9
21
52
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.8
7.9
41
158
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.4
7.9
20
48
I50
ICD-10 Finland
Heart failure
6.2
7.8
20
34
C07AG02
ATC
carvedilol; oral
7.7
7.8
17
23
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
7.7
7.8
17
23
XW5WT
NOMESCO Finland
Other blood specimen with radiologicl guidance
46.1
7.7
9
*
WW200
NOMESCO Finland
Immunization
7.0
7.7
18
27
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.5
7.7
52
229
XF640, ,
NOMESCO Finland
6.7
7.5
18
28
E66.8
ICD-10 Finland
Other obesity
6.2
7.5
19
32
M10.0
ICD-10 Finland
Idiopathic gout
6.2
7.5
19
32
XFE00
NOMESCO Finland
Epicardial ultrasonography
8.0
7.5
16
21
XX4BW, ,
NOMESCO Finland
81.9
7.4
8
*
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
81.9
7.4
8
*
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
81.9
7.4
8
*
H11.3
ICD-10 Finland
Conjunctival haemorrhage
3.8
7.4
23
64
RK320, ,
NOMESCO Finland
13.8
7.4
12
9
I26
ICD-10 Finland
Pulmonary embolism
13.8
7.4
12
9
XX1XW
NOMESCO Finland
Extensive written report from radiologist
8.7
7.4
15
18
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
4.3
7.4
19
46
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
+∞
7.3
7
*
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
7.6
7.3
16
22
C09DA01
ATC
losartan and diuretics; oral
3.6
7.3
24
70
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
6.8
7.2
17
26
C08CA10
ATC
nilvadipine; oral
20.6
7.2
10
5
C07AB03
ATC
atenolol; systemic
4.4
7.1
18
43
Z3229
NOMESCO Finland
Other healthcare associate professional
2.8
7.1
36
137
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
7.1
90
515
C10AA01
ATC
simvastatin; oral
1.9
7.0
123
787
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
6.9
47
208
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
9.6
6.8
13
14
Q25.0
ICD-10 Finland
Patent ductus arteriosus
40.9
6.8
8
*
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
7.4
6.8
15
21
JN3AD
NOMESCO Finland
Abdominal CT examination
2.7
6.7
38
153
Q21.10
ICD-10 Finland
Persistent ostium secundum
23.1
6.7
9
*
A11CC03
ATC
alfacalcidol; systemic
23.1
6.7
9
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
23.1
6.7
9
*
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
6.1
6.7
17
29
E66.00
ICD-10 Finland
Metabolic syndrome
6.1
6.7
17
29
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
12.6
6.6
11
9
R99
ICPC
Respiratory disease other
9.0
6.6
13
15
TPX10
NOMESCO Finland
Implantation of vascular injection port
6.4
6.6
16
26
C09CA03
ATC
valsartan; oral
3.6
6.5
22
65
I35.0
ICD-10 Finland
Aortic (valve) stenosis
3.6
6.5
22
65
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.7
6.5
36
143
N05CF01
ATC
zopiclone; oral
1.9
6.5
115
734
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.3
6.5
25
81
FXD00
NOMESCO Finland
Use of ECHLA without concurrent surgical procedure
71.2
6.4
7
*
L04AA01
ATC
[U] ciclosporin
14.7
6.4
10
7
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
3.4
6.4
23
71
WX002
NOMESCO Finland
Sedation and analgesia
2.1
6.4
66
348
M10
ICD-10 Finland
Gout
6.2
6.4
16
27
N03AX16
ATC
[U] pregabalin
2.1
6.4
72
393
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
6.3
82
470
I83.2
ICD-10 Finland
Varicose veins of lower extremities with both ulcer and inflammation
18.5
6.3
9
5
FXE00
NOMESCO Finland
Use of ECLA
+∞
6.3
6
*
I28.8
ICD-10 Finland
Other specified diseases of pulmonary vessels
+∞
6.3
6
*
GD1CN
NOMESCO Finland
Lung circulation isotope imaging
+∞
6.3
6
*
3A064, ,
NOMESCO Finland
27.2
6.3
8
*
7AX01, ,
NOMESCO Finland
27.2
6.3
8
*
K77
ICPC
Heart failure
6.5
6.2
15
24
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
7.9
6.2
13
17
I20.09
ICD-10 Finland
Unstable angina
3.9
6.2
18
48
TK800
NOMESCO Finland
Hemodialysis
10.3
6.1
11
11
I20.90
ICD-10 Finland
Angina pectoris, unspecified
5.7
6.1
16
29
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.1
6.0
26
90
I25.2
ICD-10 Finland
Old myocardial infarction
3.3
6.0
23
74

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
120
155
11.67
93.82
9.5
2.6
313.57
254.25
ng/l
0.46
115
137
224
625
9.26
88.21
12.2
2.8
1483.90
1163.54
ng/l
1.02
217
520
149
274
9.17
86.68
4.5
1.8
18.35
22.79
%
3.37
133
241
85
79
14.20
82.69
5.7
2.4
21.29
22.97
s
0.64
79
68
53
26
24.15
71.20
1.5
1.2
2.24
1.67
u/ml
—
25
9
178
477
7.02
69.63
8.6
2.3
386.05
9406.07
umol/l
3.28
173
407
110
214
7.25
58.43
16.6
6.2
1.28
0.90
mmol/l
0.33
85
173
81
132
7.83
50.29
5.3
4.5
—
—
—
0
0
45
36
14.34
47.03
7.9
4.1
6.36
8.64
kpa
4.77
45
36
170
583
5.00
46.36
5.3
2.2
3.45
3.14
mg/l
0.63
162
482
236
1061
5.43
45.14
49.5
10.5
1.69
1.21
inr
8.28
82
290
110
297
5.08
39.50
1.6
1.4
644.57
547.12
titre
0.27
35
59
133
425
4.60
38.51
7.6
3.0
881.85
428.56
ng/l
0.27
120
322
139
470
4.41
37.13
8.4
1.7
1.59
1.44
mg/l
0.16
107
354
106
303
4.70
35.04
11.1
3.2
0.79
0.83
mmol/l
2.53
100
278
149
582
3.87
31.56
7.0
3.7
—
—
—
0
0
189
868
3.80
31.27
7.3
3.1
121.48
33.98
ng/l
0.42
164
577
77
185
5.14
31.20
6.8
2.9
1.71
2.07
mmol/l
0.28
64
144
30
25
13.11
30.29
1.3
1.1
—
—
—
0
0
61
125
5.77
29.47
22.9
7.0
24.55
24.82
mmol/l
0.19
61
125
210
1100
3.55
26.97
13.4
5.8
0.70
0.69
%
0.13
202
1007
201
1025
3.51
26.96
10.0
3.6
34.87
35.27
g/l
0.49
195
946
31
33
10.28
26.60
8.6
5.5
61.54
62.42
%
0.06
31
33
212
1134
3.49
25.96
13.7
5.7
2.46
2.90
%
2.72
204
1042
212
1140
3.46
25.61
14.3
6.0
9.12
8.63
%
1.44
204
1049
68
173
4.70
25.42
26.5
4.8
—
—
—
0
0
31
36
9.41
24.93
8.8
4.1
2.21
1.90
mmol/l
0.23
24
23
31
36
9.41
24.93
8.8
4.1
5.05
4.88
kpa
0.59
31
36
213
1161
3.41
24.91
13.9
5.9
24.97
29.09
%
6.26
205
1069
194
1014
3.26
24.08
6.0
2.4
111.88
119.89
ug/l
0.18
187
921
215
1199
3.33
23.78
13.2
5.6
0.62
0.56
e9/l
2.17
202
1040
207
1134
3.26
23.50
15.7
6.1
—
—
—
0
0
32
42
8.34
23.36
1.1
1.1
—
—
—
0
0
215
1207
3.29
23.35
13.3
5.6
0.04
0.04
e9/l
0.60
202
1047
220
1252
3.33
23.34
14.0
5.7
0.17
0.19
e9/l
1.06
208
1092
217
1235
3.26
22.81
13.8
5.6
1.63
2.04
e9/l
3.38
205
1096
206
1148
3.16
22.27
13.7
5.7
59.38
56.10
%
3.33
198
1061
62
163
4.46
22.09
2.1
3.0
—
—
—
0
0
78
246
3.85
21.67
3.1
2.8
2.15
1.60
%
2.98
73
221
76
241
3.81
20.90
25.4
6.1
104.72
104.52
mmol/l
0.12
76
241
86
297
3.57
20.81
3.7
1.6
—
—
—
0
0
44
92
5.37
20.55
32.1
6.5
—
—
—
0
0
42
89
5.27
19.29
2.2
2.1
1.12
1.51
g/l
1.60
34
77
28
41
7.38
18.55
1.1
1.0
—
—
—
0
0
224
1396
2.93
18.24
17.0
8.9
4.36
3.93
e9/l
1.89
212
1223
201
1187
2.81
18.11
17.6
5.4
1.19
1.22
mmol/l
8.74
180
1016
109
468
3.00
18.10
4.4
2.5
510.62
544.77
mosm/kgh2o
1.05
97
402
59
176
3.87
17.54
2.6
2.9
88.52
63.32
e9/l
2.96
46
138
140
702
2.74
17.20
6.5
3.2
7.41
7.40
ph
0.57
30
127
108
481
2.86
16.57
4.1
2.2
3.67
7.05
e6/l
1.27
97
435
188
1107
2.65
16.49
16.9
4.9
1.19
1.22
mmol/l
9.77
180
987
69
242
3.35
15.99
1.5
1.4
—
—
—
0
0
15
0
+∞
15.75
6.2
0.0
—
—
—
0
0
132
671
2.63
15.44
4.4
2.0
162.22
284.43
u/l
0.53
127
634
19
6
33.48
14.97
1.3
1.3
—
—
—
0
0
122
619
2.55
14.09
12.3
6.3
—
—
—
0
0
48
144
3.74
14.05
1.2
1.2
323.44
161.36
iu/ml
—
10
58
210
1371
2.49
13.85
15.0
3.7
6.70
6.37
mmol/l
1.71
203
1274
56
189
3.37
13.70
8.7
3.6
0.75
0.70
%
0.06
26
66
52
172
3.41
13.11
8.4
3.6
0.63
0.45
%
0.40
24
55
26
51
5.45
12.91
3.8
2.4
0.83
0.91
nmol/l
0.22
21
40
51
169
3.39
12.81
9.1
3.6
0.55
0.23
%
0.23
22
44
174
1079
2.31
12.41
21.9
8.4
0.00
0.00
e9/l
0.20
155
874
131
721
2.37
12.35
5.8
2.7
55.00
171.78
e6/l
0.61
116
549
42
127
3.65
12.11
35.4
6.9
91.89
94.03
%
0.59
42
127
41
124
3.64
11.81
36.0
6.7
0.66
0.70
%
0.23
41
124
41
125
3.61
11.67
36.1
6.7
1.25
1.35
%
0.33
41
125
51
179
3.19
11.64
8.5
3.6
0.05
0.05
%
0.04
21
55
122
666
2.33
11.58
5.7
2.7
0.56
0.47
e6/l
0.15
110
507
44
143
3.40
11.36
7.9
4.2
7.41
7.41
ph
—
7
12
119
649
2.31
11.26
5.6
2.7
—
—
—
0
0
21
41
5.41
10.46
3.8
3.8
4.32
3.94
e9/l
0.41
21
41
97
502
2.33
10.23
3.4
2.6
459.10
185.31
mg/l
0.28
75
291
61
255
2.71
10.13
4.1
2.5
9.83
7.34
umol/l
0.86
56
219
72
327
2.54
10.12
1.6
1.6
—
—
—
0
0
83
403
2.42
10.10
1.7
1.8
—
—
—
0
0
16
11
15.22
10.10
4.5
3.0
33.98
132.97
ug/l
1.20
16
11
245
1837
2.34
10.10
11.9
3.8
13.35
11.40
mm/h
1.42
237
1640
40
132
3.31
10.06
4.3
3.1
4.07
4.57
pmol/l
2.42
34
118
26
64
4.33
9.90
1.8
1.2
27.63
2.41
u/ml
—
6
8
13
5
26.97
9.89
2.5
15.0
—
—
—
0
0
36
113
3.46
9.78
8.0
4.3
—
—
—
0
0
26
65
4.26
9.70
1.8
1.2
13.94
11.65
u/ml
—
8
10
21
44
5.03
9.68
4.1
3.7
59.81
57.32
%
0.49
21
44
81
396
2.39
9.67
1.3
1.2
29.12
32.29
iu/ml
0.17
22
118
30
85
3.79
9.47
7.0
5.0
—
—
—
0
0
61
267
2.58
9.20
3.4
1.6
—
—
—
0
0
21
30
7.40
9.18
5.4
2.4
—
—
—
0
0
97
523
2.22
9.15
3.7
3.1
10.43
6.17
mg/mmol
0.37
78
287
137
859
2.03
8.60
7.1
3.1
70.38
156.26
e6/l
0.51
117
595
45
179
2.76
8.16
2.5
1.5
—
—
—
0
0
98
553
2.10
8.11
3.5
2.5
6.25
7.05
mmol/l
1.34
91
456
20
33
6.38
7.98
3.9
3.7
—
—
—
0
0
18
39
4.83
7.98
7.6
5.1
—
—
—
0
0
127
799
1.97
7.71
3.4
2.9
—
—
—
0
0
49
214
2.52
7.37
3.0
1.5
—
—
—
0
0
11
7
16.19
7.28
4.4
1.0
—
—
—
0
0
215
1638
1.92
7.06
11.3
3.3
—
—
—
0
0
73
388
2.14
6.96
4.8
2.5
3.34
2.67
e6/l
0.25
49
212
116
733
1.90
6.79
3.9
2.3
—
—
—
0
0
10
6
17.14
6.78
1.2
2.0
—
—
—
0
0
18
34
5.54
6.56
3.2
2.4
14.39
15.49
%
—
7
17
18
35
5.38
6.42
4.3
3.2
—
—
—
0
0
15
23
6.78
6.41
2.6
3.3
—
—
—
0
0
6
0
+∞
6.27
5.8
0.0
—
—
—
0
0
55
273
2.22
6.18
4.3
1.4
—
—
—
0
0
82
474
1.98
6.17
1.7
1.6
414.02
15707254.72
pmol/l
0.50
69
382
10
8
12.84
6.12
1.0
1.1
—
—
—
0
0
215
1678
1.83
6.10
7.3
3.8
—
—
—
0
0
21
64
3.44
5.97
3.1
2.6
—
—
—
0
0
14
22
6.60
5.92
1.4
1.5
—
—
—
0
0
14
22
6.60
5.92
2.3
2.0
87.14
89.03
%
0.34
14
22
26
92
2.98
5.82
6.2
3.1
0.57
0.67
%
0.66
26
92
86
517
1.90
5.72
2.3
1.4
2.05
2.15
g/l
0.25
64
284
17
47
3.76
5.56
1.3
1.4
—
—
—
0
0
26
95
2.89
5.51
6.2
3.0
1.35
1.11
%
0.66
26
95
22
74
3.12
5.37
5.5
6.0
1.70
1.15
mmol/l
0.92
22
74
39
179
2.34
5.25
4.6
3.6
1.22
1.23
mmol/l
0.58
34
157
34
148
2.45
5.14
1.6
1.4
—
—
—
0
0
16
45
3.69
5.11
1.8
5.8
—
—
—
0
0
16
37
4.49
5.01
1.3
1.4
—
—
—
0
0
13
25
5.37
4.82
2.1
2.4
52.50
35.48
ug/min
—
6
14
19
64
3.09
4.63
3.7
4.7
66.25
26.34
mg/l
0.39
13
53
7
5
14.26
4.59
1.1
15.0
—
—
—
0
0
7
5
14.26
4.59
2.3
2.0
—
—
—
0
0
13
27
4.97
4.55
1.2
1.1
—
—
—
0
0
19
65
3.04
4.52
3.7
4.6
32.22
130.46
mg/l
0.53
14
54
10
15
6.84
4.50
2.2
1.3
—
—
—
0
0
7
6
11.88
4.29
1.3
1.5
—
—
—
0
0
192
1534
1.61
4.24
5.2
2.8
63.80
41.65
u/l
4.19
185
1399
9
13
7.08
4.19
1.1
1.0
—
—
—
0
0
91
608
1.69
4.11
1.8
1.5
18.75
21.05
nmol/l
0.68
85
494
146
1100
1.59
4.07
4.4
2.5
—
—
—
0
0
75
482
1.72
3.89
1.9
1.7
1051.77
1233.04
nmol/l
1.05
63
342
10
19
5.39
3.85
1.1
1.3
—
—
—
0
0
136
1018
1.58
3.85
3.5
2.2
73.56
78.89
nmol/l
1.64
128
884
16
55
3.01
3.79
1.1
2.4
—
—
—
0
0
7
8
8.91
3.79
1.4
1.7
10.34
9.36
mmol/l
—
7
8
11
24
4.70
3.78
2.5
2.3
—
—
—
0
0
6
5
12.19
3.77
5.5
2.4
47.92
60.80
%
—
6
5
103
726
1.61
3.73
6.6
3.3
—
—
—
0
0
11
25
4.52
3.65
2.1
1.3
—
—
—
0
0
11
25
4.52
3.65
2.1
2.2
—
—
—
0
0
151
1173
1.54
3.54
6.4
3.5
0.00
0.00
estimate
-0.00
52
213
6
6
10.15
3.51
1.3
1.2
—
—
—
0
0
9
18
5.11
3.39
1.0
1.3
—
—
—
0
0
19
77
2.56
3.36
1.4
1.5
—
—
—
0
0
14
48
3.00
3.34
3.2
1.7
121.00
130.13
g/l
—
8
32
149
1165
1.51
3.34
8.1
4.7
0.00
0.00
estimate
0.50
52
210
44
256
1.83
3.18
1.5
1.3
—
—
—
0
0
7
12
5.93
3.03
1.9
3.1
886.00
816.67
u/ml
—
7
12
11
31
3.64
3.02
2.0
1.3
—
—
—
0
0
35
195
1.89
2.90
8.1
3.4
—
—
—
0
0
88
633
1.53
2.83
6.5
3.6
0.00
0.00
estimate
0.50
52
210
78
547
1.56
2.81
5.4
3.3
—
—
—
0
0
8
18
4.53
2.81
1.8
1.8
—
—
—
0
0
146
1168
1.45
2.77
6.3
3.5
0.00
0.00
estimate
-0.00
56
229
25
126
2.07
2.74
1.3
1.3
—
—
—
0
0
6
10
6.09
2.71
1.0
15.0
11.98
12.37
%
—
6
10
48
303
1.69
2.64
1.2
1.2
—
—
—
0
0
28
150
1.95
2.61
4.9
3.4
—
—
—
0
0
16
68
2.42
2.60
7.1
4.8
3.94
3.91
mmol/l
0.11
16
68
11
36
3.13
2.59
6.5
3.9
—
—
—
0
0
11
36
3.13
2.59
4.8
2.0
1.56
1.52
mmol/l
0.09
11
36
8
20
4.07
2.58
1.0
1.1
—
—
—
0
0
6
11
5.53
2.55
5.2
3.8
327.33
61.73
nmol/l
—
6
11
5
153
0.32
2.35
1.6
2.0
8.21
13.30
nmol/l
—
5
137
18
85
2.18
2.33
1.3
1.2
—
—
—
0
0
84
622
1.47
2.32
5.5
3.2
—
—
—
0
0
17
79
2.22
2.29
2.0
2.3
0.28
0.17
g/l
—
7
27
217
2407
0.71
2.24
4.7
4.1
6.11
5.73
mmol/l
3.74
201
2132
19
94
2.08
2.21
2.6
2.0
—
—
—
0
0
115
916
1.39
2.11
4.6
3.2
5.90
5.95
ph
—
5
65
58
799
0.67
2.09
2.2
2.5
—
—
—
0
0
9
31
2.96
2.09
1.0
1.2
—
—
—
0
0
223
2453
0.71
2.08
4.9
4.4
2.38
2.83
mmol/l
13.27
211
2200
5
10
5.06
2.08
1.4
1.4
2.16
1.79
mmol/l
—
5
10
6
15
4.05
2.05
1.3
2.3
47.32
35.38
%
—
6
15
112
893
1.39
2.04
5.6
3.1
2.31
2.36
mmol/l
2.98
107
748
9
32
2.86
2.01
2.3
1.4
—
—
—
0
0
9
32
2.86
2.01
2.1
1.6
—
—
—
0
0
215
2373
0.72
1.98
4.5
4.0
1.37
1.56
mmol/l
7.80
202
2125
9
35
2.62
1.81
5.7
2.0
10.22
6.79
mmol/l
—
9
35
7
23
3.09
1.81
5.3
3.0
34.57
3.03
nmol/l
—
7
23
7
23
3.09
1.81
4.0
1.6
4.11
3.99
mmol/l
—
7
23
122
1003
1.35
1.79
2.2
1.9
80.92
98.53
pmol/l
4.62
73
502
20
110
1.87
1.77
2.8
2.2
0.23
0.33
e6/l
0.27
20
104
267
2828
0.69
1.72
63.5
17.5
38.69
39.83
%
1.67
250
2628
219
2390
0.75
1.68
4.6
4.0
4.19
4.80
mmol/l
16.00
208
2159
5
14
3.61
1.62
1.6
1.1
—
—
—
0
0
21
123
1.76
1.55
2.2
2.5
—
—
—
0
0
5
15
3.37
1.53
1.2
1.0
—
—
—
0
0
7
27
2.63
1.52
1.0
1.1
—
—
—
0
0
28
183
1.58
1.40
3.8
3.2
—
—
—
0
0
19
112
1.74
1.38
2.9
3.1
—
—
—
0
0
6
23
2.64
1.37
4.5
1.6
104.17
107.17
mmol/l
—
6
23
6
23
2.64
1.37
1.0
1.5
—
—
—
0
0
6
23
2.64
1.37
4.5
1.6
—
—
—
0
0
51
382
1.40
1.33
1.3
1.2
39.88
11.78
u/ml
0.60
13
137
8
34
2.39
1.30
3.3
1.4
—
—
—
0
0
11
201
0.53
1.26
1.3
1.3
—
—
—
0
0
30
210
1.47
1.13
1.2
1.2
—
—
—
0
0
213
2287
0.80
1.09
4.2
3.5
1.27
1.19
mmol/l
1.21
202
2026
12
67
1.82
1.06
1.2
2.2
0.96
5549.35
u/l
—
5
20
205
1891
1.23
1.00
5.6
3.8
15.65
14.76
pmol/l
5.01
192
1682
6
118
0.50
0.96
1.3
1.8
—
—
—
0
0
10
55
1.84
0.93
1.1
1.2
—
—
—
0
0
6
28
2.16
0.92
1.7
1.1
—
—
—
0
0
17
111
1.56
0.89
1.1
1.0
—
—
—
0
0
10
57
1.78
0.84
3.0
3.6
—
—
—
0
0
69
581
1.24
0.81
1.4
1.3
0.69
1.35
u/ml
1.38
19
134
14
210
0.65
0.80
1.3
1.5
—
—
—
0
0
74
629
1.23
0.79
1.5
1.4
—
—
—
0
0
262
2503
1.24
0.79
43.8
11.8
21.45
24.78
mg/l
1.01
251
1888
0
24
0.00
0.79
0.0
1.1
—
4.40
—
0
5
10
59
1.72
0.76
5.3
2.7
—
—
—
0
0
5
24
2.10
0.75
1.2
1.1
—
—
—
0
0
7
38
1.86
0.74
1.3
1.3
—
—
—
0
0
62
522
1.23
0.73
5.7
3.9
1.02
1.02
kg/l
—
10
78
39
313
1.28
0.69
1.7
2.4
309.21
121.16
ug/g
0.48
34
224
240
2288
1.19
0.66
7.8
4.5
2.12
1.94
mu/l
1.66
228
2027
0
21
0.00
0.60
0.0
2.4
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
6
35
1.73
0.58
1.0
1.1
—
—
—
0
0
6
35
1.73
0.58
1.0
1.1
—
—
—
0
0
33
268
1.26
0.55
2.1
4.2
38.27
41.15
ug/l
0.03
22
220
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
195.57
—
0
17
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
12.0
—
1295.83
—
0
18
0
18
0.00
0.40
0.0
9.3
—
705.28
—
0
18
10
72
1.40
0.37
2.4
1.5
—
—
—
0
0
10
72
1.40
0.37
2.4
1.4
—
—
—
0
0
10
72
1.40
0.37
2.4
1.4
—
—
—
0
0
9
71
1.28
0.36
2.2
3.0
—
—
—
0
0
24
199
1.22
0.36
1.8
1.3
—
—
—
0
0
10
73
1.38
0.35
2.4
1.5
—
—
—
0
0
216
2227
0.91
0.31
6.6
4.5
41.83
38.25
mmol/mol
6.09
209
2013
7
52
1.35
0.31
1.1
1.1
—
—
—
0
0
32
362
0.87
0.27
2.4
3.0
0.61
0.80
ug/l
0.95
19
236
5
75
0.66
0.26
1.8
1.6
—
—
—
0
0
13
106
1.24
0.23
1.2
1.2
—
—
—
0
0
13
157
0.82
0.23
1.4
1.4
—
25.88
—
0
15
7
93
0.75
0.22
1.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
7.33
—
0
13
54
505
1.08
0.18
4.5
2.7
2.46
2.46
mmol/l
0.18
47
435
10
82
1.23
0.17
15.3
9.0
—
—
—
0
0
5
68
0.73
0.17
1.0
1.1
—
—
—
0
0
6
77
0.78
0.16
1.3
1.3
—
—
—
0
0
25
275
0.90
0.15
5.8
3.8
—
—
—
0
0
64
608
1.07
0.14
1.5
1.6
1.39
1.26
mmol/l
0.77
57
513
32
297
1.09
0.13
1.2
1.2
—
—
—
0
0
5
48
1.04
0.09
5.8
1.7
—
—
—
0
0
6
56
1.07
0.08
2.2
1.4
168.17
161.86
pmol/l
—
6
56
7
67
1.05
0.08
3.0
1.5
—
—
—
0
0
23
216
1.07
0.07
1.2
1.8
—
—
—
0
0
23
244
0.94
0.06
1.9
1.7
—
—
—
0
0
15
162
0.92
0.06
1.5
1.2
—
—
—
0
0
263
2646
0.97
0.05
37.6
10.8
—
—
—
0
0
59
605
0.97
0.05
3.9
5.2
2.14
3.61
ug/l
0.98
48
525
266
2666
0.99
0.00
29.8
9.1
23.85
24.12
u/l
0.11
261
2531
98
982
1.00
0.00
2.8
2.0
—
—
—
0
0
7
77
0.91
0.00
1.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
16.12
—
0
5
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
6
59
1.02
-0.00
3.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
4.75
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
7.53
—
0
8
0
6
0.00
-0.00
0.0
1.3
—
0.55
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
14.16
—
0
5
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.3
—
3.55
—
0
6

Mortality – FinRegistry

↥

Association

Association between endpoint I9_HYPTENSPUL and mortality.

Females

Parameter HR [95% CI] p-value
I9_HYPTENSPUL 4.18 [3.33, 5.24] < 0.001
Birth year 0.994 [0.99, 1.0] 0.19

During the follow-up period (1.1.1998 — 31.12.2019), 588 out of 1066 females with I9_HYPTENSPUL died.

Males

Parameter HR [95% CI] p-value
I9_HYPTENSPUL 4.585 [3.19, 6.59] < 0.001
Birth year 0.99 [0.98, 1.0] 0.026

During the follow-up period (1.1.1998 — 31.12.2019), 390 out of 643 males with I9_HYPTENSPUL died.

Mortality risk

Mortality risk for people of age

years, who have I9_HYPTENSPUL.

N-year risk Females Males
1 0.421% 0.888%
5 2.404% 5.63%
10 6.259% 13.925%
15 11.562% 25.475%
20 19.153% 39.831%

Relationships between endpoints

↥

Index endpoint: I9_HYPTENSPUL – Hypertension, Pulmonary Arterial

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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