pulmonary arterial hypertension
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
313 |
4. Check minimum number of eventsNone |
313 |
5. Include endpointsNone |
313 |
6. Filter based on genotype QC (FinnGen only) |
313 |
Control definitions (FinnGen only)
- Control exclude
- I9_HYPERTENSION
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I27
- Name in latin
- Hypertensio pulmonalis primaria
Similar endpoints
↥List of similar endpoints to
Hypertension, Pulmonary Arterial
based on the number of shared cases.
Similar with more cases:
- Secondary right heart disease
- Other pulmonary heart/vessel disease
- Pulmonary heart disease, diseases of pulmonary circulation
- Hypertensive diseases (excluding secondary)
- Hypertensive diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2950 | 1579 | 1316 |
| Only index persons | 1759 | 1100 | 659 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.03 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 65.26 | 67.03 | 63.32 |
| Only index persons | 68.00 | 69.52 | 65.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 313 | 206 | 107 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | 61.27 | 60.22 | 63.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 291
- Matched controls
- 2911
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I27.0
ICD-10 Finland
Primary pulmonary hypertension
+∞
323.0
270
*
205
Kela drug reimbursment
Chronic hypertension
+∞
187.4
159
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
242.8
146.1
140
11
G04BE03
ATC
sildenafil; oral
183.1
113.8
113
10
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
+∞
103.4
93
*
C03CA01
ATC
furosemide; systemic
16.4
98.0
219
455
B01AA03
ATC
warfarin; systemic
16.2
92.5
181
268
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
569.2
88.1
83
*
C03DA01
ATC
spironolactone; oral
21.7
84.1
132
107
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
14.7
80.3
156
211
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
11.2
67.8
154
265
C02KX04
ATC
macitentan; oral
716.7
61.1
58
*
R06.0
ICD-10 Finland
Dyspnoea
9.3
60.9
159
334
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
655.8
56.6
54
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
9.2
55.4
138
259
GD1AA
NOMESCO Finland
Thorax X-ray examination
7.7
55.3
214
773
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
14.8
55.0
98
96
I50.9
ICD-10 Finland
Heart failure, unspecified
10.7
53.1
115
167
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
19.6
45.8
71
47
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
19.6
42.1
65
42
C02KX01
ATC
bosentan; oral
+∞
41.7
39
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
57.1
41.2
48
10
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.9
37.5
96
171
I50.0
ICD-10 Finland
Congestive heart failure
11.8
35.3
68
73
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
16.2
35.1
58
44
C01AA05
ATC
digoxin; systemic
8.8
34.9
81
122
WX740
NOMESCO Finland
Nitrogen oxide therapy
72.4
33.9
38
6
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
12.5
33.7
63
63
I48
ICD-10 Finland
Atrial fibrillation and flutter
5.3
32.0
119
334
XF622
NOMESCO Finland
Measurement of minute volume of heart
+∞
30.8
29
*
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
46.8
30.7
37
9
AP2
HP
Catheterization of the right side of the heart
172.6
30.3
31
*
I10
ICD-10 Finland
Essential (primary) hypertension
4.5
30.0
144
520
J96.1
ICD-10 Finland
Chronic respiratory failure
24.3
29.7
42
20
WX872
NOMESCO Finland
Intensive care
19.5
29.5
45
27
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
9.0
29.4
66
92
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
15.0
26.7
45
35
C07AB07
ATC
bisoprolol; oral
3.9
26.3
168
758
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
10.1
26.3
54
64
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.2
24.4
114
384
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
+∞
24.3
23
*
R4110
NOMESCO Finland
Physiotherapy
4.0
24.2
122
440
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
5.1
23.6
83
209
TPH04
NOMESCO Finland
Cathetrisation of vein
4.6
23.3
93
267
B01AC11
ATC
iloprost; inhalant, parenteral
+∞
23.2
22
*
A12BA01
ATC
potassium chloride; oral
21.7
22.7
33
17
H02AB06
ATC
prednisolone; systemic
3.5
22.5
171
847
C02KX02
ATC
ambrisentan; oral
+∞
22.2
21
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
12.7
21.7
39
35
M04AA01
ATC
allopurinol; systemic
6.0
21.7
64
130
G04BE08
ATC
tadalafil; oral
118.5
20.9
22
*
Z3226
NOMESCO Finland
Physiotherapist
4.2
20.8
92
288
C08CA01
ATC
amlodipine; oral
4.0
20.7
100
339
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
7.8
19.8
47
70
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
6.6
18.9
51
91
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
14.9
18.7
31
23
ZXE40
NOMESCO Finland
More than seven and less than nine hours
19.2
18.6
28
16
103
Kela drug reimbursment
Diabetes, insulin-treated
3.9
18.3
86
280
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.9
18.1
64
158
TPH07
NOMESCO Finland
Cathetrisation of artery
5.7
18.0
55
115
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.3
18.0
115
478
383
Kela drug reimbursment
Selexipag
+∞
17.9
17
*
XF620
NOMESCO Finland
Examination of circulation with color method
101.3
17.8
19
*
AN1
HP
Coronary angiography
5.6
17.8
55
117
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.3
17.7
72
205
XF400
NOMESCO Finland
ECG with 12 standard connections
4.0
17.2
78
245
A46
ICD-10 Finland
Erysipelas
4.6
17.2
65
172
K93
ICPC
Pulmonary embolism
37.5
16.9
21
6
I27.1
ICD-10 Finland
Kyphoscoliotic heart disease
+∞
16.8
16
*
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
+∞
16.8
16
*
GD1AD
NOMESCO Finland
Thorax CT examination
8.6
16.4
36
47
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
6.8
16.4
42
70
C08CA05
ATC
nifedipine; systemic
8.9
16.3
35
44
C08DB01
ATC
diltiazem; oral
10.1
16.2
32
35
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.8
16.0
75
241
Z2446
NOMESCO Finland
Social worker
6.4
15.9
43
77
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
8.1
15.8
36
50
B01AC27
ATC
selexipag; oral
+∞
15.8
15
*
Z94.2
ICD-10 Finland
Lung transplant status
168.6
15.6
16
*
B01AB05
ATC
enoxaparin; parenteral
3.0
15.6
113
501
XF404
NOMESCO Finland
Ambulatory ECG
5.1
15.5
51
116
207
Kela drug reimbursment
Chronic arrhythmias
4.1
15.4
66
195
R03AC02
ATC
salbutamol; inhalant
2.8
15.4
170
981
B01AB10
ATC
tinzaparin; parenteral
6.3
15.4
42
76
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.5
15.2
47
99
ZXE20
NOMESCO Finland
More than three and less than five hours
4.1
15.2
64
186
C08CA02
ATC
felodipine; oral
9.1
15.2
32
39
L04AA06
ATC
mycophenolic acid; systemic
33.7
15.0
19
6
GD2SN
NOMESCO Finland
Lung ventilation SPECT
59.9
14.9
17
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
3.6
14.9
78
270
201
Kela drug reimbursment
Chronic cardiac insufficiency
6.4
14.9
40
71
AP3
HP
Catheterization of the right and left side of the heart
84.4
14.7
16
*
334
Kela drug reimbursment
Treprostinil
+∞
14.7
14
*
B01AC21
ATC
treprostinil; parenteral
+∞
14.7
14
*
42600
ICD-8 Finland
Pulmonary heart disease, Cor pulmonale
+∞
14.7
14
*
127
Kela drug reimbursment
Transplant complication
38.2
14.6
18
5
62
HP
Catheterization and pressure measurement of the right side of the heart
157.5
14.6
15
*
GDG10
NOMESCO Finland
Bilateral transplantation of lung
157.5
14.6
15
*
C09AA02
ATC
enalapril; systemic
4.1
14.1
58
165
R28
ICPC
Limited function/disability (R)
25.3
14.0
19
8
ZX108
NOMESCO Finland
Inhalation
25.3
14.0
19
8
Z01.8
ICD-10 Finland
Other specified special examinations
3.2
13.9
84
326
ZX120
NOMESCO Finland
Intravenous
4.3
13.7
54
147
GD1UN
NOMESCO Finland
Lung circulation SPECT
78.9
13.7
15
*
J01MA12
ATC
levofloxacin; systemic
3.5
13.7
73
257
FB1BC
NOMESCO Finland
Extensive angiography of arteria pulmonalis
+∞
13.6
13
*
FBB20
NOMESCO Finland
Thrombendarterectomy of pulmonary artery in chronic obstruction
+∞
13.6
13
*
C02KX05
ATC
riociguat; oral
146.5
13.6
14
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
6.6
13.5
35
59
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
5.9
13.4
38
72
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.7
13.4
34
56
TFP20
NOMESCO Finland
Cardiodefibrillation
6.0
13.2
37
69
C07AB02
ATC
metoprolol; systemic
3.4
13.1
70
246
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
7.4
13.1
31
46
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
52.4
13.0
15
*
Z3231
NOMESCO Finland
Registered nurse
2.8
12.9
102
466
TGC00
NOMESCO Finland
Bronchial lavation
13.1
12.8
22
18
Z2221
NOMESCO Finland
Medical doctor
2.7
12.6
107
510
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
25.7
12.6
17
7
SPAT1262
SPAT
Handing over of treatment supplies
3.5
12.6
64
217
R50.9
ICD-10 Finland
Fever, unspecified
3.7
12.5
58
182
A10BA02
ATC
metformin; oral
3.1
12.2
77
303
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.7
12.2
42
100
K78
ICPC
Atrial fibrillation/flutter
5.4
12.1
37
77
XG466
NOMESCO Finland
Sleep oxymetry
9.0
12.1
25
30
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.2
11.8
46
124
I50.1
ICD-10 Finland
Left ventricular failure
6.9
11.7
29
46
J45.9
ICD-10 Finland
Asthma, unspecified
3.3
11.7
64
229
M10.9
ICD-10 Finland
Gout, unspecified
7.1
11.6
28
43
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
6.2
11.6
31
55
GD1FN
NOMESCO Finland
Lung ventilation isotope imaging
124.7
11.5
12
*
G47.3
ICD-10 Finland
Sleep apnoea
3.4
11.4
58
196
R5140
NOMESCO Finland
Monitoring the use of the aid
5.0
11.3
37
83
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
7.6
11.3
26
37
C03AA03
ATC
hydrochlorothiazide; oral
6.2
11.2
30
53
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.8
11.2
38
89
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.2
11.2
63
230
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
12.6
11.0
19
16
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
16.3
11.0
17
11
T90
ICPC
Diabetes non-insulin dependent
3.2
10.8
61
222
WX892
NOMESCO Finland
Monitored bed care
5.0
10.8
35
78
3AC01
NOMESCO Finland
NA
22.5
10.8
15
7
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
7.8
10.7
24
33
ZXD05
NOMESCO Finland
Urgent procedure
2.5
10.6
100
499
C01DA14
ATC
isosorbide mononitrate; oral
3.4
10.6
53
177
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
113.9
10.5
11
*
PH7FT
NOMESCO Finland
Inmplantation of filter to inferior vena cava with radiological guidance
113.9
10.5
11
*
4160A
ICD-9 Finland
Chronic pulmonary heart disease, Primary pulmonary hypertension
+∞
10.5
10
*
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
10.5
10
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
5.8
10.4
29
54
XG410
NOMESCO Finland
Flow-volume spirometry
6.5
10.2
26
43
C01BD01
ATC
amiodarone; systemic
9.7
10.2
20
22
C02AC05
ATC
moxonidine; oral
41.6
10.0
12
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
7.0
10.0
24
37
A10BB12
ATC
glimepiride; oral
6.0
9.9
27
49
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
6.2
9.9
26
45
A10BH01
ATC
sitagliptin; oral
5.2
9.8
30
63
I50
ICD-10 Finland
Heart failure
9.6
9.7
19
21
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.4
9.6
35
88
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
18.3
9.5
14
8
A07AA09
ATC
vancomycin; oral
31.1
9.5
12
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
4.5
9.4
33
80
R04.0
ICD-10 Finland
Epistaxis
4.4
9.4
34
85
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
22.6
9.4
13
6
4019X
ICD-9 Finland
Essential hypertension, Unspecified
+∞
9.4
9
*
I20.99
ICD-10 Finland
Angina pectoris, unspecified
5.5
9.4
27
53
C09BA02
ATC
enalapril and diuretics; systemic
8.2
9.3
20
26
L04AX01
ATC
azathioprine; systemic
6.0
9.3
25
45
A10BB01
ATC
glibenclamide; oral
6.7
9.0
22
35
C07AA07
ATC
sotalol; systemic
6.7
9.0
22
35
Z73.3
ICD-10 Finland
Stress, not elsewhere classified
11.2
8.9
16
15
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
9.9
8.9
17
18
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
3.2
8.7
46
159
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
51.5
8.7
10
*
C09CA01
ATC
losartan; oral
2.8
8.7
59
239
N18.8
ICD-10 Finland
Other chronic renal failure
16.9
8.6
13
8
M34.1
ICD-10 Finland
CR(E)ST syndrome
28.4
8.5
11
*
S97
ICPC
Chronic ulcer skin
5.6
8.5
24
46
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.6
8.5
67
299
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
8.3
8.5
18
23
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
92.6
8.5
9
*
FB1AC
NOMESCO Finland
Angiography of arteria pulmonalis
92.6
8.5
9
*
K99
ICPC
Cardiovascular disease other
9.9
8.4
16
17
K82
ICPC
Pulmonary heart disease
+∞
8.4
8
*
PH3BC
NOMESCO Finland
Extensive flebography of internal organs with X-ray
+∞
8.4
8
*
N02AX02
ATC
tramadol; systemic, rectal
2.1
8.3
127
779
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
5.3
8.2
24
48
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
5.3
8.2
24
48
C09DA06
ATC
candesartan and diuretics; oral
7.2
8.2
19
28
WX882
NOMESCO Finland
High dependency care
6.6
8.2
20
32
J94.8
ICD-10 Finland
Other specified pleural conditions
17.8
8.1
12
7
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
34.4
8.1
10
*
RK110
NOMESCO Finland
NA
34.4
8.1
10
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.3
8.1
40
132
WX725
NOMESCO Finland
Noninvasive ventilation
6.0
8.0
21
37
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
4.3
7.8
28
70
A10AE04
ATC
insulin glargine; parenteral
4.8
7.8
25
56
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
8.4
7.7
16
20
R02
ICPC
Shortness of breath/dyspnoea
3.0
7.7
44
161
GBB00
NOMESCO Finland
Tracheostomy
19.0
7.7
11
6
I26
ICD-10 Finland
Pulmonary embolism
19.0
7.7
11
6
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
4.1
7.6
29
77
XF402
NOMESCO Finland
ECG with work load test
3.5
7.5
34
105
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
4.7
7.5
24
54
7AX01
NOMESCO Finland
NA
82.0
7.4
8
*
XX4BW
NOMESCO Finland
NA
82.0
7.4
8
*
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
82.0
7.4
8
*
C08CA13
ATC
lercanidipine; oral
4.2
7.4
27
69
FL1AC
NOMESCO Finland
Left cardioangiography
11.3
7.4
13
12
GD1BT
NOMESCO Finland
Biopsy of lung with X-ray guidance
+∞
7.3
7
*
P01BA02
ATC
hydroxychloroquine; oral
3.3
7.3
36
119
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.4
7.3
34
108
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
7.2
125
792
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.2
7.2
37
126
A10AE05
ATC
insulin detemir; parenteral
6.3
7.2
18
30
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
8.3
7.2
15
19
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.8
7.2
48
193
C09AA05
ATC
ramipril; oral
2.4
7.2
66
318
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
7.2
112
681
C02EA02
ATC
NA
12.4
7.1
12
10
J01MA14
ATC
moxifloxacin; systemic
3.4
7.1
33
104
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.8
7.1
47
186
R03BB04
ATC
tiotropium bromide; inhalant
3.3
7.0
35
117
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
5.1
7.0
21
44
SPAT1254
SPAT
Administration of medicine
2.7
6.9
50
211
R4190
NOMESCO Finland
Nutritional therapy
5.6
6.9
19
36
A10BH05
ATC
linagliptin; oral
6.4
6.9
17
28
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
4.9
6.9
21
45
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
11.3
6.9
12
11
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
11.3
6.9
12
11
RK320
NOMESCO Finland
NA
17.2
6.8
10
6
Q25.0
ICD-10 Finland
Patent ductus arteriosus
41.0
6.8
8
*
I83.2
ICD-10 Finland
Varicose veins of lower extremities with both ulcer and inflammation
41.0
6.8
8
*
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
41.0
6.8
8
*
R07.4
ICD-10 Finland
Chest pain, unspecified
2.2
6.7
74
388
Q21.10
ICD-10 Finland
Persistent ostium secundum
23.1
6.7
9
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.0
6.7
38
138
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.6
6.7
22
51
E66.00
ICD-10 Finland
Metabolic syndrome
8.1
6.7
14
18
XFE00
NOMESCO Finland
Epicardial ultrasonography
8.1
6.7
14
18
M10.0
ICD-10 Finland
Idiopathic gout
7.1
6.6
15
22
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
10.4
6.6
12
12
WX720
NOMESCO Finland
Own respiration
6.4
6.6
16
26
J01FF01
ATC
clindamycin; systemic
2.1
6.5
78
424
D64.9
ICD-10 Finland
Anaemia, unspecified
3.0
6.5
37
135
A02BC02
ATC
pantoprazole; systemic
1.9
6.5
174
1280
XW5WT
NOMESCO Finland
Other blood specimen with radiologicl guidance
71.3
6.4
7
*
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
5.4
6.4
18
35
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
5.8
6.4
17
31
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.8
6.4
41
162
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
18.5
6.3
9
5
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
+∞
6.3
6
*
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
+∞
6.3
6
*
I28.9
ICD-10 Finland
Disease of pulmonary vessels, unspecified
+∞
6.3
6
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.3
6.2
60
294
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
6.2
107
673
N05CF01
ATC
zopiclone; oral
2.0
6.1
99
603
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
8.9
6.1
12
14
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
6.9
6.1
14
21
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
10.3
6.1
11
11
H11.3
ICD-10 Finland
Conjunctival haemorrhage
4.5
6.1
20
47
Mortality – FinRegistry
↥Association
Association between endpoint I9_HYPTENSPUL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPTENSPUL | 4.18 [3.33, 5.24] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.19 |
During the follow-up period (1.1.1998 — 31.12.2019), 588 out of 1066 females with I9_HYPTENSPUL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPTENSPUL | 4.585 [3.19, 6.59] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 390 out of 643 males with I9_HYPTENSPUL died.
Mortality risk
Mortality risk for people of age
years, who have I9_HYPTENSPUL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.421% | 0.888% |
| 5 | 2.404% | 5.63% |
| 10 | 6.259% | 13.925% |
| 15 | 11.562% | 25.475% |
| 20 | 19.153% | 39.831% |
Relationships between endpoints
↥Index endpoint: I9_HYPTENSPUL – Hypertension, Pulmonary Arterial
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data