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Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours

EFO MESH Endpoint Browser PheWeb

J10_CHEMGASRESP

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J68
  • Hospital discharge: ICD-9 — 506
  • Hospital discharge: ICD-8 — 516[1-2]
  • Cause of death: ICD-10 — J68
  • Cause of death: ICD-9 — 506
  • Cause of death: ICD-8 — 516[1-2]

2 out of 7 registries used, show all original rules.

321

4. Check minimum number of events

None

321

5. Include endpoints

None

321

6. Filter based on genotype QC (FinnGen only)

308

Control definitions (FinnGen only)

Control exclude
J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J60-J70
Name in latin
Morbositates respiratoriae ex inhalatione chemicalium, gasorum, fumorum et vaporum

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3900 1869 1984
Only index persons 2958 1403 1555
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.06
Only index persons 0.06 0.05 0.06
Median age at first event (years)
Whole population 46.70 48.34 45.06
Only index persons 43.67 45.69 41.84

-FinnGen-

Key figures

All Female Male
Number of individuals 308 119 189
Unadjusted period prevalence (%) 0.07 0.04 0.09
Median age at first event (years) 45.23 44.77 45.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
321
Matched controls
3210
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
51610
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of other dust
+∞
98.1
89
*
J68.0
ICD-10 Finland
Bronchitis and pneumonitis due to chemicals, gases, fumes and vapours
+∞
70.5
65
*
J68.3
ICD-10 Finland
Other acute and subacute respiratory conditions due to chemicals, gases, fumes and vapours
+∞
58.1
54
*
J68.9
ICD-10 Finland
Unspecified respiratory condition due to chemicals, gases, fumes and vapours
+∞
49.2
46
*
51620
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of fumes
+∞
32.9
31
*
4950A
ICD-9 Finland
Extrinsic allergic alveolitis, Farmers' lung
+∞
22.1
21
*
J67.0
ICD-10 Finland
Farmer lung
+∞
20.0
19
*
J68.4
ICD-10 Finland
Chronic respiratory conditions due to chemicals, gases, fumes and vapours
+∞
15.8
15
*
J68.2
ICD-10 Finland
Upper respiratory inflammation due to chemicals, gases, fumes and vapours, not elsewhere classified
+∞
14.7
14
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.5
11.9
45
144
J45.9
ICD-10 Finland
Asthma, unspecified
2.7
11.8
79
350
R06.0
ICD-10 Finland
Dyspnoea
2.4
11.7
111
580
R03AC02
ATC
salbutamol; inhalant
2.3
11.7
194
1283
H02AB06
ATC
prednisolone; systemic
2.1
9.7
169
1109
5062A
ICD-9 Finland
Respiratory conditions due to chemical fumes and vapours, Upper respiratory inflammation due to fumes and vapours
+∞
9.4
9
*
J68.1
ICD-10 Finland
Pulmonary oedema due to chemicals, gases, fumes and vapours
+∞
8.4
8
*
R03BA02
ATC
budesonide; inhalant
2.3
8.2
69
336
5060A
ICD-9 Finland
Respiratory conditions due to chemical fumes and vapours, Bronchitis and pneumonitis due to fumes and vapours
+∞
7.3
7
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.1
6.9
74
397
Y0499
ICD-8 Finland
Investigation of respiratory system
11.3
6.9
12
11
J45.1
ICD-10 Finland
Nonallergic asthma
3.0
6.8
31
111
T58
ICD-10 Finland
Toxic effect of carbon monoxide
23.1
6.7
9
*
X47
ICD-10 Finland
Accidental poisoning by and exposure to carbon monoxide and other gases and vapours
71.2
6.4
7
*
R03AK07
ATC
formoterol and budesonide; inhalant
2.1
6.4
68
363
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
6.3
123
808
J68.8
ICD-10 Finland
Other respiratory conditions due to chemicals, gases, fumes and vapours
+∞
6.3
6
*
N02AX02
ATC
tramadol; systemic, rectal
1.8
6.2
144
996
R03BA01
ATC
beclometasone; inhalant
2.3
6.0
49
234

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
57
274
2.31
6.95
6.6
9.0
95.34
95.66
%
0.22
52
266
93
546
1.99
6.78
1.7
1.7
1.32
1.27
mg/l
0.06
71
428
19
52
3.82
6.29
3.8
3.7
2.26
2.47
mmol/l
0.19
14
32
19
52
3.82
6.29
3.8
3.7
8.50
8.31
kpa
0.19
19
52
19
52
3.82
6.29
3.8
3.7
4.85
4.97
kpa
0.28
19
52
19
55
3.61
5.82
2.7
2.3
17.03
15.29
%
—
10
29
16
43
3.86
5.44
1.8
1.8
1.64
1.65
mmol/l
0.01
16
43
56
302
2.03
5.07
7.0
8.5
1.59
1.07
mmol/l
0.36
41
246
15
32
4.86
5.06
1.5
1.8
90.19
90.20
%
0.00
15
32
191
1491
1.69
4.98
5.6
5.2
6.67
6.76
mmol/l
0.25
178
1400
33
145
2.42
4.90
7.3
6.0
24.75
24.57
mmol/l
0.08
33
145
10
17
6.03
4.16
4.5
2.1
13.23
13.28
%
—
10
17
37
184
2.14
4.14
4.4
6.4
—
—
—
0
0
139
1043
1.59
3.93
4.8
3.9
33.27
47.59
ng/l
0.79
105
740
13
36
3.72
3.54
2.2
3.4
—
—
—
0
0
81
551
1.63
3.36
5.7
4.3
1.02
1.02
kg/l
0.17
11
70
10
23
4.45
3.33
1.3
1.4
—
—
—
0
0
153
1205
1.52
3.32
24.1
14.3
1.39
1.27
inr
0.91
55
372
34
179
2.01
3.29
4.1
3.1
7.43
7.39
ph
—
8
24
14
49
2.94
3.23
3.8
2.6
—
—
—
0
0
159
1273
1.49
3.13
6.4
6.1
0.20
0.19
e9/l
0.11
143
1143
157
1263
1.48
2.97
6.1
5.9
1.80
1.80
e9/l
0.00
141
1143
153
1234
1.46
2.81
6.2
5.8
0.04
0.04
e9/l
0.19
137
1095
22
106
2.15
2.70
6.5
4.2
—
—
—
0
0
126
990
1.45
2.61
4.7
3.6
5.25
5.70
ph
—
10
81
139
1114
1.44
2.58
4.0
5.1
35.40
35.60
g/l
0.17
126
1047
15
62
2.49
2.58
2.6
1.4
—
—
—
0
0
12
44
2.79
2.57
1.4
2.0
0.31
0.96
g/l
—
7
35
11
38
2.96
2.44
2.6
1.5
—
—
—
0
0
32
184
1.82
2.43
3.6
4.4
1.50
0.53
%
0.78
12
65
143
1163
1.41
2.40
6.4
6.4
—
—
—
0
0
150
1231
1.41
2.39
6.3
5.8
0.62
0.60
e9/l
0.53
135
1089
171
1440
1.40
2.33
8.6
9.6
4.34
4.18
e9/l
0.38
150
1283
88
661
1.46
2.26
6.0
4.1
0.00
0.00
estimate
0.50
28
217
14
60
2.39
2.25
3.4
2.2
—
—
—
0
0
34
206
1.73
2.18
3.7
4.4
1.46
0.91
%
0.35
13
82
6
14
4.35
2.16
1.8
1.4
—
—
—
0
0
32
192
1.74
2.13
3.4
4.6
0.18
0.13
%
0.14
11
67
140
1153
1.38
2.12
7.1
6.2
8.64
8.75
%
0.15
135
1092
149
1244
1.37
2.05
5.0
3.8
0.00
0.00
estimate
0.50
30
242
139
1149
1.37
2.03
6.5
5.9
2.93
2.84
%
0.17
134
1087
272
2517
1.53
2.01
18.0
15.0
23.23
23.41
mg/l
0.03
229
2002
100
787
1.39
1.96
2.9
3.3
1950.17
1420.28
ng/l
0.55
88
667
15
72
2.14
1.89
2.3
1.4
—
—
—
0
0
34
215
1.65
1.89
8.9
7.7
—
—
—
0
0
16
79
2.08
1.89
13.2
8.9
—
—
—
0
0
148
1250
1.34
1.84
6.2
5.2
0.00
0.00
estimate
-0.00
30
228
5
12
4.21
1.83
1.8
1.3
75.20
68.29
%
—
5
7
9
35
2.62
1.81
2.8
2.4
—
—
—
0
0
215
1922
1.36
1.81
7.0
7.9
75.37
78.56
u/l
0.71
203
1799
7
23
3.09
1.81
1.1
1.0
—
—
—
0
0
30
186
1.68
1.80
3.6
4.6
0.20
0.18
%
—
10
62
98
779
1.37
1.79
3.0
2.6
57.96
63.22
u/l
0.35
91
732
75
572
1.41
1.75
5.2
3.8
—
—
—
0
0
149
1268
1.33
1.73
5.0
3.8
0.00
0.00
estimate
-0.00
27
216
22
126
1.80
1.73
4.8
3.2
—
—
—
0
0
5
13
3.89
1.72
1.8
1.3
0.60
1.34
%
—
5
8
45
314
1.50
1.67
1.3
1.3
536.00
590.72
titre
—
10
69
15
77
1.99
1.62
1.7
1.5
262.73
343.54
mu/l
0.75
15
72
18
99
1.87
1.61
3.9
3.7
24.53
24.88
mmol/l
0.28
18
94
95
765
1.34
1.58
2.7
3.5
—
—
—
0
0
97
786
1.34
1.55
3.1
3.0
7.78
8.07
mmol/l
0.22
84
658
15
79
1.94
1.52
2.5
5.3
41.43
158.41
mg/l
—
9
63
15
79
1.94
1.52
2.5
5.3
56.41
39.93
mg/l
—
9
63
6
21
2.89
1.51
1.0
1.4
—
—
—
0
0
91
733
1.34
1.51
5.2
4.3
—
—
—
0
0
12
58
2.11
1.51
2.8
6.0
—
—
—
0
0
201
1805
1.30
1.49
4.0
3.8
15.06
14.89
pmol/l
0.40
178
1620
17
95
1.83
1.46
2.1
1.3
—
—
—
0
0
52
385
1.42
1.44
1.2
1.3
18.73
34.32
iu/ml
1.15
16
125
31
207
1.55
1.41
4.3
3.7
—
—
—
0
0
62
477
1.37
1.38
1.4
1.4
2.80
2.61
g/l
0.25
42
309
66
514
1.36
1.36
1.2
1.2
3.53
0.97
u/ml
0.41
16
150
204
1848
1.29
1.35
4.4
4.0
11.92
12.31
mm/h
0.14
191
1703
38
269
1.47
1.33
1.3
1.4
—
—
—
0
0
150
1312
1.27
1.31
5.5
6.8
11.19
11.57
umol/l
0.22
140
1249
16
91
1.80
1.31
2.1
2.0
—
—
—
0
0
34
237
1.49
1.29
7.3
6.2
1.48
1.40
mmol/l
0.20
34
231
132
1139
1.27
1.29
6.5
6.4
1.20
1.21
mmol/l
0.96
122
1034
17
100
1.74
1.26
2.1
1.3
—
—
—
0
0
118
1008
1.27
1.24
3.1
2.6
164.13
135.44
ug/l
0.79
107
928
143
1250
1.26
1.24
7.1
7.2
1.21
1.21
mmol/l
0.30
122
1063
17
101
1.72
1.22
2.1
1.3
—
—
—
0
0
17
101
1.72
1.22
2.1
1.3
—
—
—
0
0
5
19
2.66
1.22
1.4
1.4
—
—
—
0
0
190
1719
1.26
1.22
5.6
4.2
—
—
—
0
0
30
207
1.50
1.20
5.7
3.5
—
—
—
0
0
17
102
1.70
1.18
2.2
1.3
—
—
—
0
0
67
535
1.32
1.17
2.9
2.7
3.03
5.64
e6/l
0.99
61
476
10
50
2.03
1.17
2.9
1.4
—
—
—
0
0
91
758
1.28
1.17
4.0
4.4
7.41
7.40
ph
0.41
26
132
85
702
1.29
1.16
3.7
3.4
—
—
—
0
0
5
114
0.43
1.14
1.0
1.1
—
—
—
0
0
21
135
1.59
1.14
10.0
12.5
—
—
—
0
0
26
177
1.51
1.12
1.1
1.4
—
—
—
0
0
46
351
1.36
1.09
2.7
2.2
21.45
22.90
%
0.34
36
305
27
188
1.48
1.05
2.7
3.6
65.30
66.65
g/l
0.48
27
174
123
1076
1.23
1.02
13.7
10.2
0.00
0.00
e9/l
0.48
107
894
115
1000
1.23
1.01
2.2
2.0
91.40
93.24
pmol/l
0.16
70
546
52
410
1.32
1.00
1.5
1.8
—
—
—
0
0
92
781
1.25
1.00
2.5
2.1
124.26
227.95
u/l
3.17
87
742
86
725
1.25
0.99
3.1
3.2
40.05
222.58
mg/l
0.86
61
483
5
23
2.19
0.98
5.2
1.3
—
—
—
0
0
5
23
2.19
0.98
1.4
1.3
4117.00
1874.13
e6/l
—
5
16
8
146
0.54
0.95
1.1
1.3
—
—
—
0
0
66
544
1.27
0.92
1.8
1.8
471.30
8621122.78
pmol/l
0.50
56
464
21
143
1.50
0.92
1.0
1.2
225.05
112.84
iu/ml
—
8
56
80
677
1.24
0.89
2.7
2.9
363.96
6512.80
umol/l
2.62
68
590
84
715
1.24
0.89
4.9
4.1
—
—
—
0
0
42
328
1.32
0.88
1.5
1.6
—
—
—
0
0
34
257
1.36
0.87
4.0
3.5
6.04
5.73
kpa
0.81
34
248
29
214
1.39
0.86
3.6
2.6
4.47
4.40
kpa
0.06
29
203
72
606
1.24
0.85
2.5
2.1
3.01
3.03
mg/l
0.03
63
526
83
710
1.23
0.84
3.5
3.2
0.32
0.47
e6/l
0.42
69
529
60
496
1.26
0.82
4.5
3.9
102.49
171.68
ng/l
0.49
43
401
6
32
1.89
0.82
1.7
1.3
—
—
—
0
0
248
2357
1.23
0.81
5.5
5.8
41.14
40.21
mmol/mol
0.71
231
2211
0
24
0.00
0.79
0.0
3.4
—
71.40
—
0
5
6
33
1.83
0.79
2.0
1.8
—
—
—
0
0
6
33
1.83
0.79
2.0
2.2
—
—
—
0
0
9
53
1.72
0.76
1.3
1.2
—
—
—
0
0
91
795
1.20
0.75
3.5
3.4
50.81
132.33
e6/l
0.48
75
606
89
776
1.20
0.75
4.0
3.7
8.74
8.06
mg/mmol
0.05
64
508
236
2243
1.20
0.71
4.8
4.5
2.06
1.93
mu/l
0.66
217
2043
5
26
1.94
0.71
2.0
1.5
—
—
—
0
0
119
1070
1.18
0.70
4.5
4.6
3.17
2.50
ug/l
0.27
108
974
268
2579
1.24
0.70
21.3
17.7
3.98
3.99
mmol/l
0.44
263
2509
7
42
1.68
0.69
6.6
2.1
—
—
—
0
0
191
1788
1.17
0.67
4.7
4.0
—
—
—
0
0
5
28
1.80
0.66
2.2
2.2
32.60
33.07
pg
—
5
28
29
225
1.32
0.66
3.4
4.3
—
—
—
0
0
7
44
1.60
0.65
1.0
1.3
—
—
—
0
0
124
1126
1.16
0.64
2.8
2.7
—
—
—
0
0
78
683
1.19
0.63
3.6
3.1
—
—
—
0
0
22
165
1.36
0.62
2.6
3.0
—
—
—
0
0
56
654
0.83
0.62
1.7
1.7
1.93
1.41
mmol/l
0.67
40
541
59
504
1.21
0.62
2.0
1.7
1121.39
1163.29
nmol/l
0.17
50
394
43
356
1.24
0.60
1.3
1.2
1.16
6.72
u/ml
0.96
14
132
39
320
1.25
0.59
1.3
1.2
—
—
—
0
0
28
220
1.30
0.59
2.3
2.9
75.80
70.51
e9/l
0.17
20
175
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
5
87
0.57
0.57
5.4
4.8
—
—
—
0
0
93
834
1.16
0.56
2.5
3.4
2.36
2.35
mmol/l
0.29
85
741
6
39
1.55
0.53
1.8
2.8
3.80
4.77
e9/l
—
6
39
10
66
1.53
0.53
1.9
1.3
—
—
—
0
0
36
431
0.81
0.52
3.6
3.1
3.08
1.61
e6/l
0.56
22
248
6
40
1.51
0.52
2.0
3.4
58.67
58.83
%
—
6
40
99
898
1.15
0.51
4.0
4.0
90.16
74.39
e6/l
0.09
78
646
69
609
1.17
0.51
1.7
1.6
17.37
20.30
nmol/l
0.82
62
519
34
280
1.24
0.51
2.2
2.4
113.15
146.01
ug/g
0.34
22
225
36
301
1.22
0.48
1.6
1.3
—
—
—
0
0
68
608
1.15
0.43
6.2
7.1
—
—
—
0
0
47
408
1.18
0.43
2.2
1.9
29.34
29.79
s
0.26
47
396
59
522
1.16
0.43
3.6
3.1
491.04
553.07
mosm/kgh2o
1.32
48
444
36
305
1.20
0.43
2.4
2.9
2.06
1.78
%
0.42
30
282
20
158
1.28
0.43
2.0
2.5
—
8.84
—
0
9
5
33
1.52
0.41
1.4
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
255.00
—
0
7
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
2.3
—
—
—
0
0
0
16
0.00
0.41
0.0
8.1
—
0.59
—
0
16
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
35.13
—
0
18
18
144
1.26
0.36
1.1
1.2
—
—
—
0
0
33
283
1.19
0.36
1.5
1.6
—
—
—
0
0
22
181
1.23
0.35
2.6
3.5
75.07
82.57
ng/l
0.24
15
166
10
73
1.38
0.35
1.6
1.6
—
—
—
0
0
10
73
1.38
0.35
1.3
1.3
—
—
—
0
0
21
252
0.82
0.33
1.3
1.4
—
—
—
0
0
6
46
1.31
0.33
1.2
1.8
72.35
64.01
%
—
6
46
17
138
1.24
0.31
2.1
3.4
4.51
4.49
pmol/l
0.02
17
122
7
54
1.30
0.30
1.3
1.4
—
—
—
0
0
27
233
1.17
0.28
2.3
2.5
0.22
0.21
g/l
0.43
27
219
58
631
0.90
0.27
2.9
2.9
0.73
0.80
ug/l
0.26
37
394
30
263
1.16
0.26
3.8
4.7
20.50
25.72
ug/l
0.09
25
214
20
169
1.20
0.26
1.4
1.9
—
—
—
0
0
244
2388
1.09
0.24
3.8
4.0
1.44
1.32
mmol/l
0.75
223
2198
69
642
1.10
0.24
1.4
1.4
—
—
—
0
0
98
927
1.08
0.24
2.9
2.9
—
—
—
0
0
13
106
1.24
0.23
1.1
1.2
—
—
—
0
0
5
39
1.29
0.23
1.0
1.1
—
—
—
0
0
5
39
1.29
0.23
1.0
1.1
—
—
—
0
0
17
144
1.19
0.22
1.1
1.3
—
21.41
—
0
10
19
163
1.18
0.22
1.2
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
4.2
—
53.90
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
3.23
—
0
10
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
13.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
184.06
—
0
12
273
2690
1.10
0.21
10.8
10.5
28.29
27.77
u/l
0.19
262
2603
0
13
0.00
0.21
0.0
5.5
—
—
—
0
0
10
80
1.26
0.20
1.6
3.0
34.88
37.93
g/l
—
10
73
13
155
0.83
0.20
1.2
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
75.07
—
0
14
25
223
1.13
0.18
1.6
1.4
—
—
—
0
0
250
2462
1.07
0.17
4.2
4.3
1.37
1.41
mmol/l
0.74
229
2273
34
312
1.10
0.16
2.3
1.6
—
—
—
0
0
10
85
1.18
0.12
1.3
1.1
—
—
—
0
0
28
259
1.09
0.12
1.4
1.3
—
—
—
0
0
11
126
0.87
0.11
2.9
2.3
—
—
—
0
0
22
238
0.92
0.10
2.5
2.5
32.65
30.93
u/l
0.21
17
202
250
2475
1.05
0.09
4.3
4.4
4.57
4.55
mmol/l
0.10
232
2300
245
2425
1.04
0.09
4.9
4.5
6.16
6.01
mmol/l
0.67
226
2213
6
56
1.07
0.08
1.0
1.1
—
—
—
0
0
5
61
0.82
0.08
1.2
2.9
—
—
—
0
0
7
83
0.84
0.07
1.3
1.2
—
—
—
0
0
97
952
1.03
0.05
2.3
2.1
—
—
—
0
0
32
307
1.05
0.05
1.2
1.5
—
—
—
0
0
281
2796
1.04
0.05
26.6
21.6
40.56
40.60
%
0.03
269
2618
23
242
0.95
0.05
1.6
1.6
—
—
—
0
0
18
169
1.07
0.05
3.6
2.8
—
—
—
0
0
281
2798
1.03
0.04
26.3
21.5
4.55
4.54
e12/l
0.09
274
2727
263
2617
1.03
0.04
16.7
13.9
—
—
—
0
0
20
210
0.95
0.03
1.4
1.4
—
—
—
0
0
13
139
0.93
0.03
3.9
4.1
—
—
—
0
0
281
2799
1.03
0.03
26.4
21.6
6.75
6.74
e9/l
0.05
274
2728
254
2528
1.02
0.03
4.7
4.9
2.71
2.70
mmol/l
0.07
233
2338
173
1724
1.01
0.00
3.5
3.2
58.51
50.23
u/l
0.47
158
1632
19
188
1.01
0.00
1.4
1.5
—
—
—
0
0
11
111
0.99
0.00
2.3
2.8
—
—
—
0
0
49
489
1.00
0.00
3.0
3.1
2.47
2.45
mmol/l
0.55
40
432
79
786
1.01
0.00
2.5
2.3
—
—
—
0
0
280
2795
1.01
0.00
26.4
21.5
242.28
242.36
e9/l
0.01
275
2730
40
395
1.01
0.00
1.8
2.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.5
—
4.99
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
1.19
—
0
8
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.6
—
8165.57
—
0
7
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
10.3
—
—
—
0
0
8
88
0.91
-0.00
1.9
2.0
21.63
22.19
s
—
8
80
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
7
71
0.99
-0.00
2.7
3.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
1.08
—
0
6
9
95
0.95
-0.00
1.9
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
22.50
—
0
6
0
7
0.00
-0.00
0.0
10.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
6
63
0.95
-0.00
2.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
35.98
—
0
6
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint J10_CHEMGASRESP and mortality.

Females

Parameter HR [95% CI] p-value
J10_CHEMGASRESP 2.547 [1.64, 3.96] < 0.001
Birth year 0.991 [0.98, 1.0] 0.057

During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 394 females with J10_CHEMGASRESP died.

Males

Parameter HR [95% CI] p-value
J10_CHEMGASRESP 2.008 [1.58, 2.55] < 0.001
Birth year 0.992 [0.98, 1.0] 0.069

During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 908 males with J10_CHEMGASRESP died.

Mortality risk

Mortality risk for people of age

years, who have J10_CHEMGASRESP.

N-year risk Females Males
1 0.175% 0.377%
5 1.164% 2.493%
10 3.067% 6.557%
15 6.139% 12.833%
20 10.725% 21.588%

Relationships between endpoints

↥

Index endpoint: J10_CHEMGASRESP – Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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