No definition available.
Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours
EFO MESH Endpoint Browser PheWeb
J10_CHEMGASRESP
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
316 |
4. Check minimum number of eventsNone |
316 |
5. Include endpointsNone |
316 |
6. Filter based on genotype QC (FinnGen only) |
316 |
Control definitions (FinnGen only)
- Control exclude
- J10_EXTERLUNG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J60-J70
- Name in latin
- Morbositates respiratoriae ex inhalatione chemicalium, gasorum, fumorum et vaporum
Similar endpoints
↥List of similar endpoints to
Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3900 | 1869 | 1984 |
| Only index persons | 2958 | 1403 | 1555 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.06 |
| Only index persons | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 46.70 | 48.34 | 45.06 |
| Only index persons | 43.67 | 45.69 | 41.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 316 | 124 | 192 |
| Unadjusted period prevalence (%) | 0.07 | 0.04 | 0.08 |
| Median age at first event (years) | 44.73 | 44.13 | 45.12 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 284
- Matched controls
- 2838
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
51610
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of other dust
+∞
85.9
78
*
J68.0
ICD-10 Finland
Bronchitis and pneumonitis due to chemicals, gases, fumes and vapours
+∞
60.6
56
*
J68.3
ICD-10 Finland
Other acute and subacute respiratory conditions due to chemicals, gases, fumes and vapours
+∞
55.0
51
*
J68.9
ICD-10 Finland
Unspecified respiratory condition due to chemicals, gases, fumes and vapours
+∞
39.5
37
*
51620
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of fumes
+∞
26.5
25
*
4950A
ICD-9 Finland
Extrinsic allergic alveolitis, Farmers' lung
+∞
21.1
20
*
J68.4
ICD-10 Finland
Chronic respiratory conditions due to chemicals, gases, fumes and vapours
+∞
14.7
14
*
J68.2
ICD-10 Finland
Upper respiratory inflammation due to chemicals, gases, fumes and vapours, not elsewhere classified
+∞
14.7
14
*
J67.0
ICD-10 Finland
Farmer lung
+∞
13.6
13
*
R03AC02
ATC
salbutamol; inhalant
2.5
12.0
166
1034
R06.0
ICD-10 Finland
Dyspnoea
2.6
10.3
94
459
J45.9
ICD-10 Finland
Asthma, unspecified
2.8
9.6
70
299
J68.1
ICD-10 Finland
Pulmonary oedema due to chemicals, gases, fumes and vapours
+∞
8.4
8
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.5
8.2
70
327
R03BA02
ATC
budesonide; inhalant
2.6
7.9
63
280
H02AB06
ATC
prednisolone; systemic
2.0
7.4
139
919
5060A
ICD-9 Finland
Respiratory conditions due to chemical fumes and vapours, Bronchitis and pneumonitis due to fumes and vapours
+∞
7.3
7
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.1
7.0
39
139
R03BA05
ATC
fluticasone; inhalant
2.4
6.5
55
255
5062A
ICD-9 Finland
Respiratory conditions due to chemical fumes and vapours, Upper respiratory inflammation due to fumes and vapours
+∞
6.3
6
*
T59.8
ICD-10 Finland
Toxic effect: Other specified gases, fumes and vapours
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
15
32
4.87
6.76
1.5
1.8
90.2
90.2
%
0.00
15
32
89
530
1.95
6.17
1.8
1.7
1.4
1.3
mg/l
0.11
68
418
19
55
3.61
5.83
2.7
2.3
17.0
15.3
%
—
10
29
16
43
3.87
5.44
1.8
1.8
1.6
1.6
mmol/l
0.01
16
43
55
296
2.04
5.01
7.0
8.8
1.6
1.0
mmol/l
0.37
40
240
32
145
2.34
4.45
7.5
6.5
24.9
24.6
mmol/l
0.13
32
145
186
1471
1.64
4.42
5.5
5.2
6.7
6.8
mmol/l
0.36
172
1378
47
253
2.01
4.27
3.5
3.5
—
—
—
0
0
9
17
5.42
3.53
4.7
2.1
13.1
13.3
%
—
9
17
135
1033
1.54
3.39
4.7
3.9
33.4
47.9
ng/l
0.78
103
730
65
418
1.70
3.35
2.1
2.0
—
—
—
0
0
31
166
1.96
2.88
3.7
3.1
1.8
1.7
mmol/l
0.05
21
119
19
84
2.34
2.83
1.8
2.9
—
—
—
0
0
6
10
6.09
2.71
1.0
1.1
—
—
—
0
0
31
173
1.88
2.57
1.5
1.7
—
—
—
0
0
137
1101
1.43
2.50
4.0
5.1
35.4
35.6
g/l
0.15
125
1033
52
344
1.61
2.40
28.0
22.5
1.3
1.3
inr
—
5
53
122
971
1.42
2.31
5.2
4.0
—
—
—
0
0
11
42
2.68
2.21
1.7
1.4
—
—
—
0
0
6
14
4.35
2.16
1.0
1.0
—
—
—
0
0
167
1418
1.38
2.10
8.7
9.6
4.3
4.2
e9/l
0.24
146
1262
85
650
1.42
1.97
6.1
4.1
0.0
0.0
estimate
0.50
27
214
146
1222
1.36
1.97
5.0
3.8
0.0
0.0
estimate
0.00
27
228
14
65
2.21
1.91
1.5
1.7
—
—
—
0
0
98
777
1.38
1.83
2.8
3.3
1950.3
1414.4
ng/l
0.54
86
660
267
2481
1.49
1.81
17.6
15.0
23.4
23.4
mg/l
0.00
224
1974
145
1234
1.32
1.68
6.2
5.2
0.0
0.0
estimate
0.00
28
225
146
1249
1.31
1.61
5.0
3.8
0.0
0.0
estimate
0.00
25
213
210
1894
1.32
1.56
7.0
7.9
75.3
78.6
u/l
0.73
198
1769
17
93
1.88
1.55
2.0
2.1
—
—
—
0
0
95
769
1.34
1.53
2.9
2.6
58.3
57.5
u/l
0.07
88
722
5
15
3.37
1.53
1.6
1.1
—
—
—
0
0
5
15
3.37
1.53
1.6
1.1
—
—
—
0
0
15
79
1.94
1.52
2.5
5.3
56.4
39.9
mg/l
—
9
63
15
79
1.94
1.52
2.5
5.3
41.4
158.4
mg/l
—
9
63
13
65
2.04
1.51
1.5
1.7
—
—
—
0
0
9
37
2.47
1.49
1.8
1.4
—
—
—
0
0
9
37
2.47
1.49
1.0
1.1
—
—
—
0
0
16
88
1.86
1.44
2.2
1.9
—
—
—
0
0
9
40
2.29
1.41
1.8
1.4
—
—
—
0
0
11
53
2.11
1.40
1.7
1.4
—
—
—
0
0
109
912
1.30
1.37
4.0
3.3
—
—
—
0
0
28
185
1.56
1.34
2.6
3.2
73.8
63.5
ml/min/173m2
0.45
12
90
12
61
2.01
1.34
2.7
1.9
134.1
125.7
g/l
0.60
12
44
17
98
1.78
1.34
4.0
3.8
24.7
24.9
mmol/l
0.14
17
93
33
227
1.51
1.33
1.9
2.0
—
—
—
0
0
148
1293
1.27
1.32
5.5
6.8
11.3
11.6
umol/l
0.14
138
1229
6
24
2.53
1.31
1.0
1.1
—
—
—
0
0
130
1119
1.27
1.30
6.5
6.4
1.2
1.2
mmol/l
1.13
119
1010
41
298
1.43
1.27
2.1
1.9
—
—
—
0
0
196
1780
1.27
1.23
3.9
3.8
15.1
14.9
pmol/l
0.48
173
1596
50
379
1.38
1.22
1.2
1.3
18.7
34.3
iu/ml
1.16
16
125
46
344
1.39
1.22
2.7
2.2
21.5
22.7
%
0.29
36
298
140
1226
1.25
1.19
7.0
7.2
1.2
1.2
mmol/l
0.47
118
1036
6
26
2.33
1.19
1.2
1.3
275.0
287.7
u/l
—
6
26
33
234
1.46
1.17
7.2
6.6
1.5
1.4
mmol/l
0.29
33
225
5
20
2.52
1.15
1.0
1.1
—
—
—
0
0
199
1820
1.25
1.13
4.5
4.0
12.0
12.3
mm/h
0.10
187
1678
115
992
1.25
1.10
3.1
2.6
165.7
136.4
ug/l
0.79
104
914
66
537
1.29
1.02
1.8
1.8
471.3
8734056.5
pmol/l
0.50
56
458
62
501
1.30
1.01
1.2
1.2
4.0
1.0
u/ml
0.41
14
145
5
23
2.19
0.98
1.2
2.0
—
—
—
0
0
5
23
2.19
0.98
1.2
2.0
—
—
—
0
0
5
23
2.19
0.98
1.2
2.0
—
—
—
0
0
21
141
1.52
0.97
1.0
1.2
225.1
113.1
iu/ml
—
8
55
7
37
1.91
0.94
1.3
1.4
—
—
—
0
0
26
185
1.44
0.93
2.8
3.6
65.3
66.7
g/l
0.45
26
171
6
28
2.16
0.92
1.2
1.1
—
—
—
0
0
8
42
1.93
0.89
1.5
1.3
—
—
—
0
0
79
669
1.24
0.88
2.7
2.9
362.0
6652.2
umol/l
2.62
67
577
71
596
1.25
0.86
2.5
2.1
3.0
3.0
mg/l
0.03
62
517
8
47
1.72
0.81
1.6
1.7
—
—
—
0
0
33
252
1.35
0.81
1.9
2.1
—
—
—
0
0
124
1109
1.19
0.80
4.7
4.2
—
—
—
0
0
12
74
1.65
0.79
1.3
1.2
—
—
—
0
0
38
298
1.31
0.78
2.2
1.9
—
—
—
0
0
48
389
1.28
0.78
1.5
1.4
—
—
—
0
0
88
764
1.21
0.77
2.4
2.1
126.9
230.6
u/l
3.04
83
725
28
211
1.36
0.75
3.3
2.6
4.4
4.4
kpa
0.00
28
201
111
988
1.19
0.75
2.2
2.0
91.0
93.4
pmol/l
0.20
66
541
5
25
2.02
0.73
1.0
1.1
—
—
—
0
0
7
39
1.81
0.73
1.7
1.4
—
—
—
0
0
7
40
1.77
0.71
1.7
1.8
—
—
—
0
0
5
27
1.87
0.68
1.0
1.1
—
—
—
0
0
80
698
1.20
0.67
3.6
3.1
0.3
0.5
e6/l
0.43
64
516
118
1067
1.17
0.65
4.6
4.6
3.2
2.5
ug/l
0.28
107
971
243
2325
1.20
0.65
5.5
5.8
41.2
40.2
mmol/mol
0.73
226
2181
32
254
1.29
0.62
3.8
3.5
5.9
5.7
kpa
0.45
32
246
5
30
1.68
0.61
1.2
1.3
—
—
—
0
0
57
486
1.21
0.61
4.4
3.9
93.5
173.6
ng/l
0.57
40
393
12
80
1.52
0.60
1.3
1.2
—
—
—
0
0
55
641
0.83
0.60
1.7
1.7
2.0
1.4
mmol/l
0.68
39
530
42
348
1.24
0.59
1.3
1.2
1.2
6.8
u/ml
0.96
14
129
263
2542
1.21
0.58
20.9
17.7
4.0
4.0
mmol/l
0.45
258
2472
35
424
0.80
0.56
3.7
3.0
3.1
1.6
e6/l
0.57
21
242
230
2202
1.16
0.55
4.6
4.5
2.1
1.9
mu/l
0.68
211
2002
9
61
1.49
0.54
1.9
1.3
—
—
—
0
0
6
39
1.55
0.53
1.2
1.1
—
—
—
0
0
10
66
1.53
0.53
2.0
1.4
—
—
—
0
0
47
402
1.20
0.50
2.2
1.9
29.3
29.8
s
0.30
47
390
22
174
1.28
0.46
2.6
3.5
75.1
79.6
ng/l
0.14
15
160
5
83
0.60
0.46
1.4
2.1
—
—
—
0
0
90
819
1.14
0.45
2.5
3.4
2.4
2.3
mmol/l
0.28
81
721
13
95
1.38
0.44
1.5
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
554.4
—
0
7
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
34.7
—
0
6
56
497
1.15
0.40
2.1
1.7
1142.0
1164.3
nmol/l
0.08
47
388
13
97
1.35
0.40
3.2
2.3
34.9
39.1
u/l
0.44
13
88
0
18
0.00
0.40
0.0
3.8
—
104.7
—
0
18
5
35
1.44
0.39
2.0
1.5
—
—
—
0
0
11
80
1.39
0.39
8.7
1.8
—
—
—
0
0
34
290
1.19
0.39
9.4
8.1
—
—
—
0
0
220
2274
0.89
0.38
16.4
15.4
40.0
40.5
%
0.33
152
1642
63
568
1.14
0.36
2.7
2.4
—
—
—
0
0
5
79
0.63
0.36
3.6
1.8
1.9
4.1
mg/l
—
5
56
66
602
1.12
0.32
1.6
1.6
17.5
20.3
nmol/l
0.72
59
515
7
55
1.28
0.30
1.0
1.1
—
3.7
—
0
6
7
56
1.26
0.29
1.6
1.4
—
—
—
0
0
8
67
1.20
0.26
1.9
1.6
—
—
—
0
0
58
630
0.90
0.26
2.9
2.9
0.7
0.8
ug/l
0.29
37
393
17
142
1.21
0.25
1.1
1.3
—
21.4
—
0
10
21
244
0.85
0.25
1.3
1.4
—
—
—
0
0
6
81
0.74
0.24
1.3
1.2
—
—
—
0
0
6
83
0.72
0.24
1.3
1.2
—
—
—
0
0
29
257
1.14
0.23
3.9
4.8
20.9
24.5
ug/l
0.06
24
211
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
57.6
—
0
11
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
26
230
1.14
0.21
2.3
2.4
0.2
0.2
g/l
0.48
26
216
41
448
0.90
0.21
3.1
2.8
1.1
0.9
e6/l
0.22
26
263
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
7
59
1.19
0.18
1.0
1.2
—
—
—
0
0
7
62
1.13
0.17
1.4
1.1
—
—
—
0
0
20
224
0.89
0.16
1.3
1.7
—
—
—
0
0
9
78
1.16
0.15
1.7
3.1
34.5
37.8
g/l
—
9
69
239
2354
1.06
0.15
3.8
4.0
1.4
1.3
mmol/l
0.64
218
2165
268
2652
1.07
0.13
10.7
10.5
28.5
27.8
u/l
0.29
257
2568
17
152
1.13
0.12
1.6
1.4
—
—
—
0
0
15
134
1.13
0.11
2.1
3.4
4.5
4.5
pmol/l
0.02
15
118
5
45
1.11
0.10
1.2
1.2
—
—
—
0
0
6
55
1.09
0.09
1.0
1.2
—
0.9
—
0
5
245
2427
1.04
0.08
4.2
4.3
1.4
1.4
mmol/l
0.66
223
2235
5
60
0.83
0.08
1.2
1.5
—
—
—
0
0
6
70
0.85
0.07
1.5
1.4
—
—
—
0
0
6
73
0.82
0.07
2.3
1.6
—
—
—
0
0
9
105
0.85
0.06
1.0
1.0
—
—
—
0
0
22
233
0.94
0.06
2.5
2.5
32.6
30.8
u/l
0.23
17
197
154
1522
1.02
0.05
3.1
2.9
—
—
—
0
0
11
120
0.91
0.05
1.3
1.3
—
—
—
0
0
233
2315
1.02
0.04
15.3
14.0
80.8
80.2
ml/min/173m2
0.15
196
1905
86
872
0.98
0.03
5.1
4.0
21.0
21.6
%
0.19
44
394
245
2440
1.02
0.02
4.3
4.4
4.6
4.5
mmol/l
0.05
226
2261
240
2390
1.02
0.02
4.8
4.5
6.2
6.0
mmol/l
0.65
221
2180
13
128
1.02
0.00
3.2
3.2
23.5
24.2
mmol/l
0.49
13
117
98
978
1.00
0.00
2.3
2.3
73.9
75.1
nmol/l
0.16
88
868
48
481
1.00
0.00
3.0
3.1
2.5
2.4
mmol/l
0.57
39
426
170
1701
1.00
0.00
3.5
3.2
58.6
50.2
u/l
0.47
156
1610
16
157
1.02
0.00
2.2
1.8
—
—
—
0
0
249
2493
0.99
0.00
4.7
4.9
2.7
2.7
mmol/l
0.01
227
2302
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
7
0.00
0.00
0.0
1.0
—
129.4
—
0
7
0
6
0.00
0.00
0.0
2.2
—
1.3
—
0
6
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
9
98
0.92
0.00
1.7
2.8
7.3
7.3
g/l
—
9
76
0
8
0.00
0.00
0.0
1.0
—
21.5
—
0
8
9
91
0.99
0.00
1.7
2.9
3.4
3.0
g/l
—
9
75
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
59
0.85
0.00
1.6
1.3
—
—
—
0
0
9
98
0.92
0.00
1.3
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
159.2
—
0
5
9
98
0.92
0.00
1.7
2.8
3.3
3.6
g/l
—
9
73
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
9
91
0.99
0.00
1.7
2.9
9.7
10.5
g/l
—
9
81
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
9
98
0.92
0.00
1.7
2.8
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
9
0.00
0.00
0.0
1.0
—
123.2
—
0
9
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint J10_CHEMGASRESP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_CHEMGASRESP | 2.547 [1.64, 3.96] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.057 |
During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 394 females with J10_CHEMGASRESP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_CHEMGASRESP | 2.008 [1.58, 2.55] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.069 |
During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 908 males with J10_CHEMGASRESP died.
Mortality risk
Mortality risk for people of age
years, who have J10_CHEMGASRESP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.175% | 0.377% |
| 5 | 1.164% | 2.493% |
| 10 | 3.067% | 6.557% |
| 15 | 6.139% | 12.833% |
| 20 | 10.725% | 21.588% |
Relationships between endpoints
↥Index endpoint: J10_CHEMGASRESP – Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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